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Applying the S&S technology platform in modern clinical genomics research hasadvance diagnosis and treatment of human diseases.
In the modern era of Next Generation Sequencing (NGS) technology, S&S is applied in clinical practice extensively. Clinicians and molecular diagnostic laboratories apply S&S using various comp... | 1 | Gene expression + Signal Transduction |
Allopolyploids are species whose increased complement of genetic material is the result of hybridization of two closely related species. Thus homeologous chromosomes in allopolyploids are equivalent, but not identical. These differences mean that the precise pattern of silencing and expression can have important phenot... | 1 | Gene expression + Signal Transduction |
Initiation in archaea is governed by TATA-binding protein (TBP), Archaeal transcription factor B (TFB), and Archaeal transcription factor E (TFE) that are homologous to eukaryotic TBP, TFIIB, and TFIIE respectively. These factors recognize the promoter core sequence (TATA box, B recognition element) upstream of the cod... | 1 | Gene expression + Signal Transduction |
In plasma spraying process, the material to be deposited (feedstock)—typically as a powder, sometimes as a liquid, suspension or wire—is introduced into the plasma jet, emanating from a plasma torch. In the jet, where the temperature is on the order of 10,000 K, the material is melted and propelled towards a substrate.... | 0 | Metallurgy |
β-catenin destabilization by ethanol is one of two known pathways whereby alcohol exposure induces fetal alcohol syndrome (the other is ethanol-induced folate deficiency). Ethanol leads to β-catenin destabilization via a G-protein-dependent pathway, wherein activated Phospholipase Cβ hydrolyzes phosphatidylinositol-(4,... | 1 | Gene expression + Signal Transduction |
If a specimen must be observed at higher magnification, it can be examined with a scanning electron microscope (SEM), or a transmission electron microscope (TEM). When equipped with an energy dispersive spectrometer (EDS), the chemical composition of the microstructural features can be determined. The ability to detec... | 0 | Metallurgy |
Although they are classically thought of working only together, GPCRs may signal through G-protein-independent mechanisms, and heterotrimeric G-proteins may play functional roles independent of GPCRs. GPCRs may signal independently through many proteins already mentioned for their roles in G-protein-dependent signaling... | 1 | Gene expression + Signal Transduction |
The LHCGRs become desensitized when exposed to LH for some time. A key reaction of this downregulation is the phosphorylation of the intracellular (or cytoplasmic) receptor domain by protein kinases. This process uncouples Gs protein from the LHCGR. | 1 | Gene expression + Signal Transduction |
A modern steel plant employs very few people per tonne, compared to the past. In South Korea, Posco employs 29,648 people to produce 28 million tonnes.
During the period 1974 to 1999, the steel industry had drastically reduced employment all around the world. In the US, it was down from 521,000 to 153,000. In Japan, fr... | 0 | Metallurgy |
A variety of other compounds are added to optimize the separation process, these additives are called modifiers. Modifying reagents react either with the mineral surfaces or with collectors and other ions in the flotation pulp, resulting in a modified and controlled flotation response.
* pH modifiers include lime (used... | 0 | Metallurgy |
tRNA (also tRNA-like) splicing is another rare form of splicing that usually occurs in tRNA. The splicing reaction involves a different biochemistry than the spliceosomal and self-splicing pathways.
In the yeast Saccharomyces cerevisiae, a yeast tRNA splicing endonuclease heterotetramer, composed of TSEN54, TSEN2, TSE... | 1 | Gene expression + Signal Transduction |
Hexaferrum and epsilon iron (ε-Fe) are synonyms for the hexagonal close-packed (HCP) phase of iron that is stable only at extremely high pressure.
A 1964 study at the University of Rochester mixed 99.8% pure α-iron powder with sodium chloride, and pressed a 0.5-mm diameter pellet between the flat faces of two diamond a... | 0 | Metallurgy |
In both prokaryotes and eukaryotes signal sequences may act co-translationally or post-translationally.
The co-translational pathway is initiated when the signal peptide emerges from the ribosome and is recognized by the signal-recognition particle (SRP). SRP then halts further translation (translational arrest only oc... | 1 | Gene expression + Signal Transduction |
In 1866, the government of the Russian Empire concluded an agreement with Prince Sergey Victorovich Kochubey, according to which the prince undertook to build a plant for the manufacture of iron rails in the south of the Russian Empire. In 1869, Kochubey sold the enterprise to John Hughes for £24,000.
In 1869, Hughes (... | 0 | Metallurgy |
A conjoined gene (CG) is defined as a gene, which gives rise to transcripts by combining at least part of one exon from each of two or more distinct known (parent) genes which lie on the same chromosome, are in the same orientation, and often (95%) translate independently into different proteins. In some cases, the tra... | 1 | Gene expression + Signal Transduction |
Ankyrin repeat and kinase domain containing 1 (ANKK1) also known as protein kinase PKK2 or sugen kinase 288 (SgK288) is an enzyme that in humans is encoded by the ANKK1 gene. The ANKK1 is a member of an extensive family of the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transducti... | 1 | Gene expression + Signal Transduction |
* Advantages
** At large, protocells are advantageous because they can store more drugs, be loaded faster than other nanomedicine delivery systems, and are more stable than liposomes. By keeping more drugs, researchers can reduce the quantity of medications needed to be administered, potentially reducing side effects a... | 1 | Gene expression + Signal Transduction |
UPt forms crystals of hexagonal symmetry (some studies hypothesize a trigonal structure instead), space group P6/mmc, cell parameters a = 0.5766 nm and c = 0.4898 nm (c should be understood as distance from planes), with a structure similar to nisnite (NiSn) and MgCd.
The compound congruently melts at 1700 °C. The enth... | 0 | Metallurgy |
The first models which tried to explain the clustering of genes were, of course, focused on operons because they were discovered before eukaryote gene clusters were. In 1999 Lawrence proposed a model for the origin operons. This selfish operon model suggests that individual genes were grouped together by vertical en ho... | 1 | Gene expression + Signal Transduction |
The crystal structure of green rust can be understood as the result of inserting the foreign anions and water molecules between brucite-like layers of iron(II) hydroxide, (). The latter has an hexagonal structure, with layer sequence AcBAcB... , where A and B are planes of hydroxide ions, and c those of (iron(II), fe... | 0 | Metallurgy |
The EPS process produces scale-free steel strip which is interchangeable with acid-pickled steel strip, yet the EPS process entails lower capital and operating (variable) cost than an acid-pickling line of equivalent output. For this reason the EPS process is considered to be a direct replacement of acid pickling.
In a... | 0 | Metallurgy |
* Trypanosoma: UUA, UUG, CUG ;
* Leishmania: AUU, AUA ;
* Tetrahymena: AUU, AUA, AUG ;
* Paramecium: AUU, AUA, AUG, AUC, GUG, GUA(?).
(Pritchard et al., 1990) | 1 | Gene expression + Signal Transduction |
Cold water pitting of copper tube occurs in only a minority of installations. Copper water tubes are usually guaranteed by the manufacturer against manufacturing defects for a period of 50 years. The vast majority of copper systems far exceed this time period but a small minority may fail after a comparatively short t... | 0 | Metallurgy |
The carboxy-terminal domain is also the binding site for spliceosome factors that are part of RNA splicing. These allow for the splicing and removal of introns (in the form of a lariat structure) during RNA transcription. | 1 | Gene expression + Signal Transduction |
Long noncoding RNAs (lncRNAs) are large transcripts (more than 200 nucleotides long) that have similar mechanism of synthesis as that of mRNAs but unlike mRNAs, lncRNAs are not translated to a protein. lncRNA contains interactor elements and structural elements. Interactor elements directly interact with other nucleic ... | 1 | Gene expression + Signal Transduction |
Neurotransmitters are tiny signal molecules stored in membrane-enclosed synaptic vesicles and released via exocytosis. Indeed, a change in electrical potential in the presynaptic cell triggers the release of these molecules. By attaching to transmitter-gated ion channels, the neurotransmitter causes an electrical alter... | 1 | Gene expression + Signal Transduction |
As mentioned before, N-acyl-homoserine lactones (AHL) are the quorum sensing signaling molecules of the gram-negative bacteria. However, these molecules may have different functional groups on their acyl chain, and also a different length of acyl chain. Therefore, there exist many different AHL signaling molecules, for... | 1 | Gene expression + Signal Transduction |
In the ovary, the FSH receptor is necessary for follicular development and expressed on the granulosa cells.
In the male, the FSH receptor has been identified on the Sertoli cells that are critical for spermatogenesis.
The FSHR is expressed during the luteal phase in the secretory endometrium of the uterus.
FSH recepto... | 1 | Gene expression + Signal Transduction |
Tell Hammeh () is a relatively small tell in the central Jordan Valley, Hashemite Kingdom of Jordan, located where the Zarqa River valley opens into the Jordan Valley.
It is the site of the earliest bloomery smelting of iron, from around 930 BC.
It is close to several of the larger tells in this part of the Jordan Va... | 0 | Metallurgy |
U12 Intron Database (U12DB) is a biological database of containing the sequence of eukaryotic introns that are spliced out by a specialised minor spliceosome that contains U12 minor spliceosomal RNA in place of U2 spliceosomal RNA. These U12-dependent introns are under-represented in genome annotations because they oft... | 1 | Gene expression + Signal Transduction |
The oldest known blast furnaces in the West were built in Durstel in Switzerland, the Märkische Sauerland in Germany, and at Lapphyttan in Sweden, where the complex was active between 1205 and 1300. At Noraskog in the Swedish parish of Järnboås, traces of even earlier blast furnaces have been found, possibly from aroun... | 0 | Metallurgy |
Bases: adenine (A), cytosine (C), guanine (G) and thymine (T) or uracil (U).
Amino acids: Alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), Glutamine (Gln, Q), Glycine (Gly, G), Histidine (His, H), Isoleucine (Ile, I), Leucine (Leu, L), Lysine (... | 1 | Gene expression + Signal Transduction |
Molten Oxide Electrolysis in steelmaking is utilizing electrons as the reducing agent instead of coke as in conventional blast furnace. For steel production, this method uses an inert anode (Carbon, Platinum, Iridium or Chromium-based alloy) and places iron ore in the cathode. The electrochemical reaction in this Molte... | 0 | Metallurgy |
Research based on the split gene theory sheds light on other basic questions of exons and introns. The exons of eukaryotes are generally short (human exons average ~120 bases, and can be as short as 10 bases) and introns are usually long (average of ~3,000 bases, and can be several hundred thousands bases long), for ex... | 1 | Gene expression + Signal Transduction |
TADs have been reported to be relatively constant between different cell types (in stem cells and blood cells, for example), and even between species in specific cases. | 1 | Gene expression + Signal Transduction |
The generally recognized first successful commercial flotation process for mineral sulphides was invented by Frank Elmore who worked on the development with his brother, Stanley. The Glasdir copper mine at Llanelltyd, near Dolgellau in North Wales was bought in 1896 by the Elmore brothers in conjunction with their fath... | 0 | Metallurgy |
Two types of sulfate-induced hot corrosion are generally distinguished: Type I takes place above the melting point of sodium sulfate, whereas Type II occurs below the melting point of sodium sulfate but in the presence of small amounts of SO.
In Type I, the protective oxide scale is dissolved by the molten salt. Sulfur... | 0 | Metallurgy |
Calmodulin mediates many crucial processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, and the immune response. Calcium participates in an intracellular signaling system by acting as a diffusible second messenger to the initial stimuli... | 1 | Gene expression + Signal Transduction |
This period was one of rapid growth for the Jameson Cells in the existing applications. Seventy-seven Cells were installed in concentrators around the world, mainly in coal and base metal operations. However, during this time, the Cell also moved into the Canadian oil sands industry for the flotation of bitumen. | 0 | Metallurgy |
In 1986, convincing evidence was provided that selenocysteine (Sec) was incorporated co-translationally. Moreover, the codon partially directing its incorporation in the polypeptide chain was identified as UGA also known as the opal termination codon. Different mechanisms for overriding the termination function of this... | 1 | Gene expression + Signal Transduction |
Bioleaching is in general simpler and, therefore, cheaper to operate and maintain than traditional processes, since fewer specialists are needed to operate complex chemical plants. And low concentrations are not a problem for bacteria because they simply ignore the waste that surrounds the metals, attaining extraction ... | 0 | Metallurgy |
Ladles can be "lip pour" design, "teapot spout" design, "lip-axis design" or "bottom pour" design:
*For lip pour design the ladle is tilted and the molten metal pours out of the ladle like water from a pitcher.
*The teapot spout design, like a teapot, takes liquid from the base of the ladle and pours it out via a lip-... | 0 | Metallurgy |
The involvement of miRNAs in diseases has led scientists to become more interested in the role of additional protein complexes, like microprocessor, that have the ability to influence or modulate the function and expression of miRNAs. Microprocessor complex component, DGCR8, is affected through the micro-deletion of 22... | 1 | Gene expression + Signal Transduction |
The apparatus for testing consists of a closed testing cabinet/chamber, where a salt water (5% NaCl) solution is atomized by means of spray nozzle(s) using pressurized air. This produces a corrosive environment of dense salt water fog (also referred to as a mist or spray) in the chamber, so that test samples exposed to... | 0 | Metallurgy |
The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several t... | 1 | Gene expression + Signal Transduction |
The ores of base metals are often sulfides. In recent centuries, reverberatory furnaces have been used to keep the charge being smelted separately from the fuel. Traditionally, they were used for the first step of smelting: forming two liquids, one an oxide slag containing most of the impurities, and the other a sulfid... | 0 | Metallurgy |
Epileptic seizures occur when there is synchrony of electrical waves in the brain. Knowing the role that ephaptic coupling plays in maintaining synchrony in electrical signals, it makes sense to look for ephaptic mechanisms in this type of pathology. One study suggested that cortical cells represent an ideal place to o... | 1 | Gene expression + Signal Transduction |
Most, if not all, metals can be sintered. This applies especially to pure metals produced in vacuum which suffer no surface contamination. Sintering under atmospheric pressure requires the use of a protective gas, quite often endothermic gas. Sintering, with subsequent reworking, can produce a great range of material p... | 0 | Metallurgy |
Electrometallurgy is a method in metallurgy that uses electrical energy to produce metals by electrolysis. It is usually the last stage in metal production and is therefore preceded by pyrometallurgical or hydrometallurgical operations. The electrolysis can be done on a molten metal oxide (smelt electrolysis) which is ... | 0 | Metallurgy |
In normal fatigue-testing of smooth specimens, about 90 percent is spent in crack nucleation and only the remaining 10 percent in crack propagation. However, in corrosion fatigue crack nucleation is facilitated by corrosion; typically, about 10 percent of life is sufficient for this stage. The rest (90 percent) of life... | 0 | Metallurgy |
Metal spraying equipment uses compressed gases which create noise. Sound levels vary with the type of spraying equipment, the material being sprayed, and the operating parameters. Typical sound pressure levels are measured at 1 meter behind the arc. | 0 | Metallurgy |
Modular screen media is typically 1 foot large by 1 or 2 feet long (4 feet long for ISEPREN WS 85 ) steel reinforced polyurethane or rubber panels. They are installed on a flat deck (no crown) that normally has a larger surface than a tensioned deck. This larger surface design compensates for the fact that rubber and ... | 0 | Metallurgy |
The Cephalodiscidae mitochondrial code (translation table 33) is a genetic code used by the mitochondrial genome of Cephalodiscidae (Pterobranchia). The Pterobranchia are one of the two groups in the Hemichordata which together with the Echinodermata and Chordata form the major clades of deuterostomes.
Code 33 is very ... | 1 | Gene expression + Signal Transduction |
While there are many methods of detecting fake precious metals, there are realistically only two options available for verifying the marked fineness of metal as being reasonably accurate: assaying the metal (which requires destroying it), or using X-ray fluorescence (XRF). XRF will measure only the outermost portion of... | 0 | Metallurgy |
As water evaporates in the boiler, the concentration of sodium carbonate increases in the boiler. In high pressure boilers, sodium carbonate is used in softening of water by lime soda process, due to this some sodium carbonate maybe left behind in the water. As the concentration of sodium carbonate increases, it underg... | 0 | Metallurgy |
A widely publicized study suggested that humans can detect more than one trillion different odors. This finding has been disputed. Critics argued that the methodology used for the estimation was fundamentally flawed, showing that applying the same argument for better-understood sensory modalities, such as vision or aud... | 1 | Gene expression + Signal Transduction |
Dehydroretinal (3,4-dehydroretinal) is a derivative metabolite of retinal belonging to the group of vitamin A as a retinaldehyde form, besides the endogenously present 3,4-dehydroretinol and 3,4-dehydroretinoic acid.
The livers of some freshwater fishes and some fish found in India contain a higher ratio of dehydroreti... | 1 | Gene expression + Signal Transduction |
At pressures above approximately 10-13 GPa and temperatures up to around 700 K, α-iron changes into a hexagonal close-packed (hcp) structure, which is also known as ε-iron or hexaferrum; the higher-temperature γ-phase also changes into ε-iron, but generally requires far higher pressures as temperature increases. The tr... | 0 | Metallurgy |
*G are involved in Rho family GTPase signaling (see Rho family of GTPases). This is through the RhoGEF superfamily involving the RhoGEF domain of the proteins' structures). These are involved in control of cell cytoskeleton remodeling, and thus in regulating cell migration. | 1 | Gene expression + Signal Transduction |
The slippery sequence for a +1 frameshift signal does not have the same motif, and instead appears to function by pausing the ribosome at a sequence encoding a rare amino acid. Ribosomes do not translate proteins at a steady rate, regardless of the sequence. Certain codons take longer to translate, because there are no... | 1 | Gene expression + Signal Transduction |
Artificial gene synthesis, or simply gene synthesis, refers to a group of methods that are used in synthetic biology to construct and assemble genes from nucleotides de novo. Unlike DNA synthesis in living cells, artificial gene synthesis does not require template DNA, allowing virtually any DNA sequence to be synthesi... | 1 | Gene expression + Signal Transduction |
The Rare Earths Facility was a production plant for various chemicals and metals including thorium, uranium, and radium. It was located in West Chicago, Illinois, USA. | 0 | Metallurgy |
On June 28, 2007, a team at the J. Craig Venter Institute published an article in Science Express, saying that they had successfully transplanted the natural DNA from a Mycoplasma mycoides bacterium into a Mycoplasma capricolum cell, creating a bacterium which behaved like a M. mycoides.
On Oct 6, 2007, Craig Venter an... | 1 | Gene expression + Signal Transduction |
RNA editing (also RNA modification) is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase. It occurs in all living organisms and is one of the most evolutionarily conserved properties of RNAs. RNA e... | 1 | Gene expression + Signal Transduction |
Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in the extracellular (outer leaflet) side of the plasma membrane by the action of neutral CDase enzyme. Sph then is either recycled back to ceramide or phosphorylated by one of the sphingosine k... | 1 | Gene expression + Signal Transduction |
Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNA to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF... | 1 | Gene expression + Signal Transduction |
The atoms in the GB are normally in a higher energy state than their equivalent in the bulk material. This is due to their more stretched bonds, which gives rise to a GB tension . This extra energy that the atoms possess is called the grain boundary energy, . The grain will want to minimize this extra energy, thus str... | 0 | Metallurgy |
Schulze in 1967 defined intermetallic compounds as solid phases containing two or more metallic elements, with optionally one or more non-metallic elements, whose crystal structure differs from that of the other constituents. Under this definition, the following are included:
# Electron (or Hume-Rothery) compounds
# Si... | 0 | Metallurgy |
Type S (90%Pt/10%Rh–Pt, by weight) thermocouples, similar to type R, are used up to 1600 °C. Before the introduction of the International Temperature Scale of 1990 (ITS-90), precision type-S thermocouples were used as the practical standard thermometers for the range of 630 °C to 1064 °C, based on an interpolation betw... | 0 | Metallurgy |
Several methods of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur. | 1 | Gene expression + Signal Transduction |
CCL7 was first characterized from osteosarcoma supernatant. CCL7 consists of 99 amino acids, which contains 23-amino acid signal peptide. The mature protein about 76 amino acids is secreted after cleavage of the signal peptide. In contrast to most chemokines, CCL7 exists in a general monomeric form, differing from the ... | 1 | Gene expression + Signal Transduction |
* Genomic Imprinting
* Paramutation
* Transposon silencing (or Histone Modifications)
* Transgene silencing
* Position effect
* RNA-directed DNA methylation | 1 | Gene expression + Signal Transduction |
In the iron and steel industry, direct reduction is a set of processes for obtaining iron from iron ore, by reducing iron oxides without melting the metal. The resulting product is pre-reduced iron ore.
Historically, direct reduction was used to obtain a burr in a low furnace. At the beginning of the 20th century, this... | 0 | Metallurgy |
Falconbridge Limited in mid-1981 commissioned a copper smelter and refinery near Timmins, Ontario, to treat concentrate from its Kidd Mine. However, at the outset, the quality of the cathode copper produced in the Kidd refinery suffered from the presence of higher than usual concentrations of lead and selenium in the c... | 0 | Metallurgy |
Rapid advance in cancer genomics and high-throughput ChIP-chip, ChIP-Seq and Bisulfite sequencing methods are providing more insight into role of chromatin remodeling in transcriptional regulation and role in cancer. | 1 | Gene expression + Signal Transduction |
The microprocessor complex consists minimally of two proteins: Drosha, a ribonuclease III enzyme; and DGCR8, a double-stranded RNA binding protein. (DGCR8 is the name used in mammalian genetics, abbreviated from "DiGeorge syndrome critical region 8"; the homologous protein in model organisms such as flies and worms is ... | 1 | Gene expression + Signal Transduction |
* CPPs have been used to transport a variety of biomolecules into cells in both vitro and in vivo. One must be cautious of which CPPs are used. For example, different CPPs promote movement into different cell types and cellular components.
* If the TIVA tag is not used within 3 months of synthesis, the FRET signal is w... | 1 | Gene expression + Signal Transduction |
Researchers at Sandia Labs, Ames National Laboratory and Iowa State University reported a 3D-printed superalloy composed of 42% aluminum, 25% titanium, 13% niobium, 8% zirconium, 8% molybdenum and 4% tantalum. Most alloys are made chiefly of one primary element, combined with low amounts of other elements. In contrast ... | 0 | Metallurgy |
Despite the high number of MAPK genes, MAPK pathways of higher plants were studied less than animal or fungal ones. Although their signaling appears very complex, the MPK3, MPK4 and MPK6 kinases of Arabidopsis thaliana are key mediators of responses to osmotic shock, oxidative stress, response to cold and involved in a... | 1 | Gene expression + Signal Transduction |
The phrase originates from the French word espoilelier, a verb conveying the meaning: to seize by violence, to plunder, to take by force. | 0 | Metallurgy |
High temperature materials are valuable for energy conversion and energy production applications. Maximum energy conversion efficiency is desired in such applications, in accord with the Carnot cycle. Because Carnot efficiency is limited by the temperature difference between the hot and cold reservoirs, higher operatin... | 0 | Metallurgy |
A base metal, such as iron (Fe) goes into aqueous solution as positively charged cation, Fe. As the metal is oxidized under anaerobic conditions by the protons of water, H ions are reduced to form molecular H. This can be written in the following ways under acidic and neutral conditions respectively:
:Fe + 2 H → Fe +... | 0 | Metallurgy |
The cell used in this process consists of an iron tank lined with carbon at the bottom.
A molten alloy of copper, crude aluminium and silicon is used as the anode. It forms the lowermost layer in the cell.
The middle layer consists of molten mixture of fluorides of sodium, aluminium and barium (cryolite + BaF).
The upp... | 0 | Metallurgy |
Lilleby closed on the same day Norway was attacked by Nazi Germany, but it did not remain closed for long. The Norwegian aluminium industry was of great strategic importance for the German government, which requested that Lilleby resume operation right away. Birger Solberg was placed in charge, because professor Peders... | 0 | Metallurgy |
Based on the method developed by Poliak and Jonas, a few models are developed in order to describe the critical strain for the onset of DRX as a function of the peak strain of the stress–strain curve. The models are derived for the systems with single peak, i.e. for the materials with medium to low stacking fault energ... | 0 | Metallurgy |
Red plague is an accelerated corrosion of copper when plated with silver. After storage, damage or use in high-humidity environment, cuprous oxide forms on the surface of the parts. The corrosion is identifiable by presence of patches of brown-red powder deposit on the exposed copper.
Red plague is caused by normally o... | 0 | Metallurgy |
Before it was flooded, Norşuntepe was located on the Altınova Plain near the mouth of the Murat River (downstream from the town of Palu, Elazığ). It is now partially submerged by the reservoir created by the Keban Dam; its top is still above the water level. The site consists of a central hill or "acropolis" measuring ... | 0 | Metallurgy |
SPIDR (scaffold protein involved in DNA repair) regulates the stability or assembly of RAD51 and DMC1 on single-stranded DNA. RAD51 and DMC1 are recombinases that act during mammalian meiosis to mediate strand exchange during the repair of DNA double-strand breaks by homologous recombination. | 1 | Gene expression + Signal Transduction |
The FLC operon is a conserved eukaryotic locus that is negatively associated with flowering via repression of genes needed for the development of the meristem to switch to a floral state in the plant species Arabidopsis thaliana. FLC expression has been shown be regulated by the presence of [https://www.uniprot.org/un... | 1 | Gene expression + Signal Transduction |
The thermocouple's behaviour is captured by a characteristic function , which needs only to be consulted at two arguments:
In terms of the Seebeck coefficients, the characteristic function is defined by
The constant of integration in this indefinite integral has no significance, but is conventionally chosen such that .... | 0 | Metallurgy |
Next to the potential antimicrobial functionality, quorum-sensing derived molecules, especially the peptides, are being investigated for their use in other therapeutic domains as well, including immunology, central nervous system disorders and oncology. Quorum-sensing peptides have been demonstrated to interact with ca... | 1 | Gene expression + Signal Transduction |
The molecular organization of the nodes corresponds to their specialized function in impulse propagation. The level of sodium channels in the node versus the internode suggests that the number IMPs corresponds to sodium channels. Potassium channels are essentially absent in the nodal axolemma, whereas they are highly... | 1 | Gene expression + Signal Transduction |
The split gene theory is a theory of the origin of introns, long non-coding sequences in eukaryotic genes between the exons. The theory holds that the randomness of primordial DNA sequences would only permit small (< 600bp) open reading frames (ORFs), and that important intron structures and regulatory sequences are de... | 1 | Gene expression + Signal Transduction |
Chemical milling or industrial etching is the subtractive manufacturing process of using baths of temperature-regulated etching chemicals to remove material to create an object with the desired shape. Other names for chemical etching include photo etching, chemical etching, photo chemical etching and photochemic... | 0 | Metallurgy |
As illustrated by the peroxisomal intracellular lactate shuttle described above, the interconversion of lactate and pyruvate between cellular compartments plays a key role in the oxidative state of the cell. Specifically, the interconversion of NAD+ and NADH between compartments has been hypothesized to occur in the mi... | 1 | Gene expression + Signal Transduction |
In metallurgy, non-ferrous metals are metals or alloys that do not contain iron (allotropes of iron, ferrite, and so on) in appreciable amounts.
Generally more costly than ferrous metals, non-ferrous metals are used because of desirable properties such as low weight (e.g. aluminium), higher conductivity (e.g. copper), ... | 0 | Metallurgy |
TRIM24 has been shown to interact with Mineralocorticoid receptor, TRIM33, Estrogen receptor alpha and Retinoid X receptor alpha. | 1 | Gene expression + Signal Transduction |
The Candelabro Trivulzio in the Milan Cathedral, a seven-branch bronze candlestick measuring 5 meters in height, has a base and lower part decorated with intricately designed ornament which is considered by many to be French work of the 13th century; the upper part with the branches was added in the second half of the ... | 0 | Metallurgy |
The lac repressor (LacI) operates by a helix-turn-helix motif in its DNA-binding domain, binding base-specifically to the major groove of the operator region of the lac operon, with base contacts also made by residues of symmetry-related alpha helices, the "hinge" helices, which bind deeply in the minor groove. This bo... | 1 | Gene expression + Signal Transduction |
ASF/SF2 is an SR protein, and as such, contains two functional modules: an arginine-serine rich region (RS domain), where the bulk of ASF/SF2 regulation takes place, and two RNA recognition motifs (RRMs), through which ASF/SF2 interacts with RNA and other splicing factors. These modules have different functions within ... | 1 | Gene expression + Signal Transduction |
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