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NIR Spectroscopic Properties of Aqueous Acids Solution
Acid content is one of the important quality attributes in determining the maturity index of agricultural product, particularly fruits. Despite the fact that much research on the measurement of acidity in fruits through non-destructive spectroscopy analysis at NIR... |
Quartz Crystal Microbalance-Based Aptasensors for Medical Diagnosis
# Introduction
Aptamers have attained popularity as a promising molecular recognition element bearing values of the dissociation constant (K d ) from picomolar to nanomolar ranges in sensing applications such as environmental safety, food safety, an... |
A Rare Case of Radius Head Epiphyseal Aneurysmal Bone Cyst with Predisposing Factor as Trauma Tuberculosis of Elbow apart from Genetic
Introduction: Aneurysmal bone cysts (ABCs) are benign aggressive bone lesions arising predominantly in the second decade of population in long bones at metaphyseal region which can cau... |
Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project
Background: The accurate estimation of iron deficiency is important in planning and implementing interventions. Ferritin is recommended as the primary measure of iron status, b... |
Combating COVID-19 with integrated traditional Chinese and Western medicine in China
, an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout the world. China has achieved rapid containment of this highly infectious disease following the principles of early ... |
Immune checkpoint blockade of programmed death-1 (PD-1) by monoclonal antibody drugs has delivered breakthroughs in the treatment of cancer. Nonetheless, small-molecule PD-1 inhibitors could lead to increases in treatment efficacy, safety, and global access. While the ligand-binding surface of apo-PD-1 is relatively fl... |
Qualitative exploration of melanoma awareness in black people in the USA
## Version 1 -author response
Reviewer: 1 Dr. Amelia Smit, The University of Sydney Comments to the Author: This is an interesting and important contribution to the literature on prevention and early detection of melanoma among Black people in ... |
Identifying Homogeneous Patterns of Injury in Paediatric Trauma Patients to Improve Risk-Adjusted Models of Mortality and Functional Outcomes
Injury is a leading cause of morbidity and mortality in the paediatric population and exhibits complex injury patterns. This study aimed to identify homogeneous groups of paedia... |
Food Insecurity and Its Sociodemographic Correlates among Afghan Immigrants in Iran
# Introduction
In the history of the modern world, the situation in Afghanistan has resulted in one of the largest displacements of mankind in search of safety and a better life [bib_ref] My body is broken like my country: identity, ... |
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies*
Intrinsically disordered proteins (IDPs) are characterized by a lack of persistent structure. Since their identification more than a decade ago, many questions regarding their functional relevance and interaction mechanisms remain unanswered. A... |
A Study of the Immunoloregulation of Double Filtration Plasmapheresis in Maintenance Hemodialysis Patients with Chronic Hepatitis C
Although a large number of drugs have been used to treat chronic hepatitis C (CHC), there still remains a great challenge to treat maintenance hemodialysis (MHD) patients with chronic hep... |
A sacrificial layer strategy for photolithography on highly hydrophobic surface and its application for electrowetting devices
Patterning micro-structures on highly hydrophobic surface by photolithography is usually inevitable for fabricating devices based on electrowetting effects. The key challenges for such photoli... |
Designed for life: biocompatible de novo designed proteins and components
A principal goal of synthetic biology is the de novo design or redesign of biomolecular components. In addition to revealing fundamentally important information regarding natural biomolecular engineering and biochemistry, functional building blo... |
Where does DNA replication start in archaea?
Genome-wide measures of DNA strand composition have been used to find archaeal DNA replication origins. Archaea seem to replicate using a single origin (as do eubacteria) even though archaeal replication factors are more like those of eukaryotes.
Use of genome sequences is ... |
Prevalence and Profile of High-Impact Chronic Pain in the United States
The multidimensional nature of chronic pain is not reflected by definitions based solely on pain duration, resulting in high prevalence estimates limiting effective policy development. The newly proposed concept of high-impact chronic pain (HICP) ... |
Tobramycin exposure from active calcium sulfate bone graft substitute
Background: Bone graft substitute such as calcium sulfate are frequently used as carrier material for local antimicrobial therapy in orthopedic surgery. This study aimed to assess the systemic absorption and disposition of tobramycin in patients tre... |
Hydrogenated vacancies lock dislocations in aluminium
Supplementary Figure 1. Process to achieve individual-dislocation configuration through 2 small-strain-amplitude cyclic compression. (a) As-fabricated pillar contains high density of 3 dislocations. (b) After 339 cycles of cyclic compression with peak stress of 330... |
Management of tumor rupture and abdominal compartment syndrome in an infant with bilateral high risk stage 4 neuroblastoma
Rationale: Tumor rupture and bleeding at initial presentation of infants with neuroblastoma (NBL) is a rare, but life threatening condition and challenge in pediatric oncology. Here, we report suc... |
Association between diabetic eye disease and other complications of diabetes: Implications for care. A systematic review
Funding informationSupport for this project was provided by the Vision Academy, a Bayer-sponsored initiative comprising over 70 leading retinal specialists.The aim of this systematic review was to e... |
Impact of grafting using thin upper pole artery ligation on living-donor adult kidney transplantation
This study aimed to investigate the impact of grafting using thin upper pole artery ligation for living-donor adult kidney transplantation. Few reports have examined the safety of thin upper pole artery ligation.Betwe... |
Oral arsenic trioxide for treating acute promyelocytic leukaemia: Implications for its worldwide epidemiology and beyond
## How oral ato treatment has influenced apl epidemiology
Acute promyelocytic leukaemia (APL) is a relatively uncommon type of highly aggressive acute myeloid leukemia, first characterised in 1957... |
Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model
## S.1 dissolution of polydisperse powders
In order to evaluate the expression that results from Eqs. (6) and (7) in the main text, we change variable to = ln( 1 ⁄ ) with... |
Effects of adenotonsillectomy on the growth of children with obstructive sleep apnoea-hypopnea syndrome (OSAHS): protocol for a systematic review
## Reviewer
## Jesús lópez alcalde cochrane associate centre of madrid (instituto ramón y cajal de investigación sanitaria / universidad francisco de vitoria) review retu... |
Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration
Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of... |
Identifying Probable Suicide Clusters in Wales Using National Mortality Data
Background: Up to 2% of suicides in young people may occur in clusters i.e., close together in time and space. In early 2008 unprecedented attention was given by national and international news media to a suspected suicide cluster among young... |
Primary small bowel adenocarcinoma with loss of nuclear expression of PMS2 after resection of mucinous cholangiocarcinoma
Mucinous cholangiocarcinoma is an extremely rare form of intrahepatic cholangiocarcinoma that has been characterized by rapid growth, widespread metastasis and poor prognosis. These tumors have bee... |
Shared properties and singularities of exoribonuclease-resistant RNAs in viruses
a b s t r a c tWhat viral RNA genomes lack in size, they make up for in intricacy. Elaborate RNA structures embedded in viral genomes can hijack essential cellular mechanisms aiding virus propagation. Exoribonucleaseresistant RNAs (xrRNAs... |
Widowhood and Mortality: A Meta-Analysis
Background: While the "widowhood effect" is well known, there is substantial heterogeneity in the magnitude of effects reported in different studies. We conducted a meta-analysis of widowhood and mortality, focusing on longitudinal studies with follow-up from the time of bereav... |
The sound of trustworthiness: Acoustic-based modulation of perceived voice personality
When we hear a new voice we automatically form a "first impression" of the voice owner's personality; a single word is sufficient to yield ratings highly consistent across listeners. Past studies have shown correlations between pers... |
Viral Bad News Sent by EVAIL
Citation: Clauss, M.; Chelvanambi, S.; Cook, C.; ElMergawy, R.; Dhillon, N. Viral Bad News Sent by EVAIL. Viruses 2021, 13, 1168. https://
# Introduction
For many years, acute and chronic viral infections have been associated with the development of cardiovascular disease (CVD). For examp... |
A Case of Cardiac Tamponade in a Patient with Metastatic Renal Cell Carcinoma on Pazopanib Treatment
Asymptomatic minimal pericardial effusion may be frequently found in patients with hypothyroidism. Cardiac tamponade secondary to hypothyroidism is rarely referenced in medical literature. Hypothyroidism as an adverse ... |
Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study
## Supplementary methods 1. multiple imputation
We used multiple imputation for variables with incomplete data (i.e. missing values for haemoglobin A1c, BMI and smoking) in all analyses. This method... |
Mapping human vulnerability to climate change in the Brazilian Amazon: The construction of a municipal vulnerability index
Vulnerability, understood as the propensity to be adversely affected, has attained importance in the context of climate change by helping to understand what makes populations and territories predi... |
Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase
Benzyl 2-O-(2-O-acetyl-3,4,5-tri-O-benzyl-α-mannopyranosyl)-( 1→2)-(4-cyano-4-deoxy-β-Darabinopyranoside) (17)TfOH (4.4 µL, 0.050 mmol) was added to a mixture of acceptor 16 (125 mg, 0.50 mmol), 2-O-acetyl-3,4,5tri-O-benzyl-α-mann... |
The Epidermis in Microgravity and Unloading Conditions and Their Effects on Wound Healing
The future objectives of human space flight are changing from low-term permanence in the International Space Station to missions beyond low Earth orbit to explore other planets. This implies that astronauts would remain exposed f... |
Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe
# Abstract
Introduction The number of new paediatric infections per year has declined in sub-Saharan Africa due to preventionof-m... |
Infected Leg Hematoma: A Rare Cause of Recurrent Leg Cellulitis
# Introduction
While traumatic muscular hematomas can occur in patients of all demographics, spontaneous muscle hematoma (SMH) is more commonly associated with the elderly population receiving treatment with anticoagulants; it is reported to occur in ap... |
ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease
PURPOSE The rho-associated coiled-coil-containing protein kinase-2 (ROCK2) signaling pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways. Selective ROCK2 inhibition with belumosudil (KD0... |
Across a significant body of research, psychopathy has often been conceptualized as a biologically based malady. In this research, genetic and neurobiological differences have been conceptualized to underlie psychopathy, while affected individuals' life experiences only influence expressed psychopathic features and the... |
Cost and operational impact of promoting upfront GeneXpert MTB/RIF test referrals for presumptive pediatric tuberculosis patients in India
BackgroundOutreach and promotion programs are essential to ensuring uptake of new public health interventions and guidelines. We assessed the costs and operation dynamics of outrea... |
Late Post Traumatic Right-sided Diaphragmatic Hernia Presenting with Acute Intestinal Obstruction and Strangulation: A Rare Presentation
We report a case of 16 year old male, who was presented to Jawaharlal Nehru Medical College, AMU, Aligarh, India as an emergency case with complaints of severe abdominal pain, diffic... |
Pneumatocele in a Ugandan female with SARS‐CoV2 infection: A case report
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no mo... |
A Simple Biomimetic Receptor Selectively Recognizing the GlcNAc2 Disaccharide in Water
Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.
## In memory of professor alberto vacca
Abstract: GlcNAc 2 is the core disaccharide fragment present i... |
Imbalanced Nutrient Intake in Cancer Survivors from the Examination from the Nationwide Health Examination Center-Based Cohort
This study was conducted to examine the nutrient intake status of cancer survivors. A total of 5224 cancer survivors, 19,926 non-cancer individuals without comorbidities (non-cancer I), and 20... |
Safety and Efficacy of Indocyanine Green in Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis of 11,047 Patients
Citation: Safiejko, K.; Tarkowski, R.; Kozlowski, T.P.; Koselak, M.; Jachimiuk, M.; Tarasik, A.; Pruc, M.; Smereka, J.; Szarpak, L. Safety and Efficacy of Indocyanine Green in Colorectal Canc... |
Early Identification, Accurate Diagnosis, and Treatment of Silicosis
Silicosis is a global problem, and it has brought about great burdens to society and patients' families. e etiology of silicosis is clear, preventable, and controllable, but the onset is hidden and the duration is long. us, it is difficult to diagnos... |
Phenotypic plasticity in nematodes
# Introduction
Modern biology's success in discovering how genes control developmental phenotypes has been due to studying genetically defined organisms in tightly controlled laboratory conditions. The invariant cell lineage of C. elegans has particularly facilitated notable progre... |
Stem cell therapy for chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD), characterized by persistent and not fully reversible airflow restrictions, is currently one of the most widespread chronic lung diseases in the world. The most common symptoms of COPD are cough, expectoration, and... |
Reliable brain morphometry from contrast‐enhanced T1w‐MRI in patients with multiple sclerosis
Brain morphometry is usually based on non-enhanced (pre-contrast) T1-weighted MRI. However, such dedicated protocols are sometimes missing in clinical examinations. Instead, an image with a contrast agent is often available. ... |
An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc-mutation-driven intestinal tumorigenesis
[fig] Figure S1: High tumor IL25 but not IL33 expression is associated with poor survival in human CRC patients. (A) Overall survival of CRC patients from the TCGA Firehose Legacy microarray da... |
VEGF and VEGFR2 bind to similar pH-sensitive sites on fibronectin, exposed by heparin-mediated conformational changes
# Results
## Equilibrium binding by enzyme-linked immunoassay (elisa)based experiments
To study the interactions between fibronectin and the angiogenic factors VEGF 165 (termed VEGF for simplicity) ... |
Programmed Death-1/Programmed Death-Ligand 1-Axis Blockade in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Stratified by Human Papillomavirus Status: A Systematic Review and Meta-Analysis
Background: Programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors have provided clinical benefit to... |
Bayesian modelling of population trends in alcohol consumption provides empirically based country estimates for South Africa
# Gather statement
This study complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER) recommendations. [bib_ref] Guidelines for Accurate and Transparent H... |
Real-time monitoring and just-in-time intervention for adherence to pre-exposure prophylaxis among men who have sex with men in China: a multicentre RCT study protocol
Background: Pre-exposure prophylaxis (PrEP) is an effective biomedical strategy to prevent transmission of HIV infection, although medication adherence... |
Prevalence of dysmenorrhea among reproductive age group in Saudi Women
Background: The condition of recurrent, crampy, lower abdominal pain during menses is defined as dysmenorrhea. The study aims to assess the factors affecting the prevalence of primary and secondary dysmenorrhea among Saudi women from the reproducti... |
Isolation, Screening, and Identification of Cellulolytic Bacteria from Natural Reserves in the Subtropical Region of China and Optimization of Cellulase Production by Paenibacillus terrae ME27-1
From different natural reserves in the subtropical region of China, a total of 245 aerobic bacterial strains were isolated o... |
Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety
Research indicates that heightened anticipatory anxiety underlies several forms of psychopathology. Anticipatory anxiety can be reliably and objectively measured in the laboratory using the No-Predictab... |
Genetic and environmental contributions to population group differences on the Raven's Progressive Matrices estimated from twins reared together and apart
We carried out two studies to test the hypothesis that genetic and environmental influences explain population group differences in general mental ability just as t... |
Influence of shift work on cardiovascular disease risk in Southern African long-distance truck drivers: a cross-sectional study
## Linear regression
## Log (frs)
## Univariable
Unstandardized β
[formula] coefficient (95% CI) P Multivariable Unstandardized β coefficient (95% CI) P Day/night shift (2-3 nights) -0.03... |
Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis
Background: This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) with chest high-resolution computed tomography (HRCT) for the rapid diagnosis of active pulmonary tuberculosis (PTB) in patients... |
What predicts regression from pre-diabetes to normal glucose regulation following a primary care nurse-delivered dietary intervention? A study protocol for a prospective cohort study
# Introduction
The prevalence of diabetes and concomitant costs continue to increase. [bib_ref] National, regional, and global trends ... |
Body Mass Index, Waist-circumference and Cardiovascular Disease Risk Factors in Iranian Adults: Isfahan Healthy Heart Program
# Introduction
Chronic non-communicable diseases (CNCDs), such as cardiovascular diseases (CVDs), cancers, (WC) which is a better predictor than BMI for obesity outcomes [bib_ref] Are waist c... |
Structural and Functional Relationships in Glaucoma Using Standard Automated Perimetry and the Humphrey Matrix
Purpose: To evaluate and compare correlations between structural and functional loss in glaucoma as assessed by optical coherence tomography (OCT), scanning laser polarimetry (GDx VCC, as this was the model u... |
Early Rehabilitation and Periprosthetic Bone Environment after Primary Total Hip Arthroplasty: A Randomized Controlled Trial
Objective: To investigate whether the periprosthetic bone environment could be affected by activity during the early rehabilitation period after primary total hip arthroplasty (THA) and to evalu... |
Night-time sedating H1-antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial
## What does this study add?
- This study compared 5-day treatment of CSU with the second-generation H 1 -antihistamine, levocetirizine (20 mg daily), with levo... |
VOSviewer and Bibliometrix
# Introduction
As the materials on a given topic increases, researchers and librarians find it more difficult to grasp the big picture of a field. Outlining the state of the art, the relationships, opportunities and main players of a given community of practitioners and scholars calls for ... |
Monitored anesthesia care in and outside the operating room
The American Society of Anesthesiologists (ASA) defines monitored anesthesia care (MAC) as a planned procedure during which the patient undergoes local anesthesia together with sedation, and analgesia is provided by an anesthesiologist[1]. A responsible anest... |
The Effect of Parenting Quality on Child Development at 36–48 Months in China’s Urban Area: Evidence from a Birth Cohort Study
Environmental exposures, especially parenting quality, are critical for later child development. This study aimed to determine the status of parenting quality and suspected development delay o... |
Lightning Strike Presenting as Fatal Lung Contusion: A Case Report
# Introduction
Lightning is a life-threatening natural disaster with an electrical energy content of 100-300 million volts and produces heat at a temperature of about 3000 °C. Prior studies estimate that there are 0.09 to 0.12 lightning strikes per 1... |
Multifunctional Templates for Minimized Osteotomy, Implantation, and Palatal Distraction with a Mini-Screw-Assisted Expander in Schizodontism and Maxillary Deficit
Purpose. Schizodontism is complete separation of a dental germ. It results in a twin tooth and supernumerary teeth. The treatment of transverse constrictio... |
Pre-hospital care time intervals among victims of road traffic injuries in Iran. A cross-sectional study
Background: Road traffic injuries (RTIs) are a major public health problem, requiring concerted efforts both for their prevention and a reduction of their consequences. Timely arrival of the Emergency Medical Servi... |
Total knee replacement: A comparison of the subvastus and medial parapatellar approaches
Objective: The goal of this study is to compare the subvastus method to the usual medial parapatellar technique for total knee replacement in patients with osteoarthritis who present to a tertiary care centre, based on quadriceps ... |
Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation
[bib_ref] The changing preference of T and B cells for partners as T-dependent..., Maclennan [/bib_ref] [bib_ref] Clonal selection and learning in the antibody system, Rajewsky [/bib_ref]... |
Recurrent Bilateral Breast Abscess Due to Nontuberculous Mycobacterial Infection
# Introduction
Mastitis is a common disease with both infectious and noninfectious causes. Most cases occur during lactation and are caused by Staphylococcus aureus and Streptococcus species; parasites and Mycobacterium tuberculosis hav... |
Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter
CLC secondary active transporters exchange Clfor H + . Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved gluta... |
A case of amyotrophic lateral sclerosis which was diagnosed with progressive dysphagia and muscle atrophy
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, th... |
Lip synechiae: A rare complication of azithromycin-associated Stevens–Johnson syndrome
Stevens-Johnson syndrome (SJS) is a severe form of erythema multiforme, is a self-limiting acute inflammatory disease of multifactorial origin, but can also present as a chronic recurrent lesion. It causes a whole plethora of lesion... |
The Impact of Load Carriage on Measures of Power and Agility in Tactical Occupations: A Critical Review
The current literature suggests that load carriage can impact on a tactical officer's mobility, and that survival in the field may rely on the officer's mobility. The ability for humans to generate power and agility... |
Origin of Pressure-induced Superconducting Phase in KxFe2−ySe2 studied by Synchrotron X-ray Diffraction and Spectroscopy
Pressure dependence of the electronic and crystal structures of K x Fe 2−y Se 2 , which has pressure-induced two superconducting domes of SC I and SC II, was investigated by x-ray emission spectrosc... |
Inflammatory bowel disease: Looking beyond the tract
Inflammatory bowel disease is a chronic inflammatory condition that encompasses Crohn's disease and ulcerative colitis. Inflammatory bowel disease is not exclusive to the gastrointestinal system, as it has been identified to be associated with extraintestinal manife... |
Operative Techniques to Prevent Dialysis Access-associated Steal Syndrome in High-risk Patients Undergoing Surgery for Hemodialysis Access: A Systematic Review
# Introduction and background
End stage renal disease (ESRD) affects more than 1500 people per million population per year. Approximately two-third of these ... |
Potential involvement of the extracranial venous system in central nervous system disorders and aging
Background: The role of the extracranial venous system in the pathology of central nervous system (CNS) disorders and aging is largely unknown. It is acknowledged that the development of the venous system is subject t... |
Elevated risk of early reoperation in total hip replacement during the stage of unit closure
A population-based registry study of total hip and knee replacements in Finland,
Background and purpose -The effects of launch or closure of an entire arthroplasty unit on the first or last patients treated in these units have... |
Accumulation of protein aggregates induces autolytic programmed cell death in hybrid tobacco cells expressing hybrid lethality
Hybrid cells ofNicotiana suaveolens x N. tabacum grow normally at 36 °C, but immediately express lethality due to probable autoimmune response when transferred from 36 to 28 °C. Our recent stu... |
Breast implant-associated anaplastic large-cell lymphoma: first case detected in a Japanese breast cancer patient
This paper details the first breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) case detected in Japan. The patient, a 67-year-old Japanese woman, was diagnosed with left unilateral breast... |
Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis
Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug resistant M. tuberculosis strains, which lead to the need of new more efficient drugs. A strategy to overcome the problem of the res... |
Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma
The spindle and kinetochore-associated protein complex (Ska) is an essential component in chromosome segregation. It comprises three proteins (Ska1, Ska2, and Ska3... |
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells
Background: Colorectal cancer (CRC) is a leading cause of cancer death globally and new biomarkers and treatments are severely needed.Method... |
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine p... |
The multimodal nature of communicative efficiency in social interaction
How does communicative efficiency shape language use? We approach this question by studying it at the level of the dyad, and in terms of multimodal utterances. We investigate whether and how people minimize their joint speech and gesture efforts i... |
Traumatic Pulmonary Pseudocyst Mimicking a Congenital Cystic Lung Disease
Traumatic pulmonary pseudocyst (TPP) is a rare entity that occurs following a trauma to the chest. It usually presents as multiple cystic lesions on thoracic imaging. It is treated conservatively and tends to completely resolve after few months.... |
Alcohol interventions, alcohol policy and intimate partner violence: a systematic review
Background: Intimate partner violence (IPV) is a significant global public health issue. The consistent evidence that alcohol use by one or both partners contributes to the risk and severity of IPV suggests that interventions that... |
Influence of additional weight on the frequency of kicks in infants with Down syndrome and infants with typical development
| Background: Infants with Down syndrome present with organic and neurological changes that may lead to a delay in the acquisition of motor skills such as kicking, a fundamental skill that is a p... |
Nonsequential double ionization with mid-infrared laser fields
Using a full-dimensional Monte Carlo classical ensemble method, we present a theoretical study of atomic nonsequential double ionization (NSDI) with mid-infrared laser fields, and compare with results from near-infrared laser fields. Unlike single-electron... |
Veno‐venous extracorporeal membrane oxygenation and prone ventilation for therapeutic management of COVID‐19
Background: The efficacy and safety of the combined use of veno-venous extracorporeal membrane oxygenation (ECMO) and prone ventilation are currently not known for coronavirus disease 2019 (COVID-19).Case prese... |
Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
## Supplementary table 1. ef mutagenesis primers
[formula] Primer Name Sequence EF D171A Forward 5'-GACTAAATAAAAGGT-3' EF D171A Reverse 5'-TAAGAGTTTAAGCGA-3' EF D174A Forward 5'-CTTTAAATTTTTGAC-3' EF D... |
Analysis of extracellular vesicle DNA at the single‐vesicle level by nano‐flow cytometry
[fig] Figure S2: Fluorescence emission spectra of SYTO 9, SYTO 13, SYTO 16, PicoGreen, SYBR Green I, and SYTO 82 without (black line) or with binding to DNA (red line) or RNA (blue line). The concentrations of RNA and DNA were b... |
Giant Keratocystic Odontogenic Tumor of the Mandible – A Case Report
Background:The keratocystic odontogenic tumor (KCOT) is a relatively rare, benign neoplasm which develops in the maxilla or mandible, arising from the dental lamina or basal cells of the oral epithelium. It is often found incidentally and brings abou... |
Rapid subcutaneous progression after immunotherapy in pretreated patients with metastatic carcinoma: two case reports
There is heterogeneity in cancer patients' responses to immune checkpoint inhibitors (ICIs), including hyperprogression, which is very rapid tumor progression following immunotherapy, and pseudoprogres... |
Imaging of brain glucose uptake by PET in obesity and cognitive dysfunction: life-course perspective
The prevalence of obesity has reached epidemic proportions and keeps growing. Obesity seems implicated in the pathogenesis of cognitive dysfunction, Alzheimer's disease and dementia, and vice versa. Growing scientific ... |
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