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Uncovering the Mechanisms Responsible for Why Language Learning May Promote Healthy Cognitive Aging
One of the great challenges facing humankind in the 21st century is preserving healthy brain function in our aging population. Individuals over 60 are the fastest growing age group in the world, and by 2050, it is estim... |
Factors associated with a SARS-CoV-2 recurrence after hospital discharge among patients with COVID-19: systematic review and meta-analysis* #
Background: The proportion of recurrences after discharge among patients with coronavirus disease 2019 was reported to be between 9.1% and 31.0%. Little is known about this issu... |
Allele dynamics plots for the study of evolutionary dynamics in viral populations
[fig_ref] Table S3: Test for directional evolution of protein sequences [/fig_ref] [fig_ref] Table S4: Test [/fig_ref]
## Steinbrueck and mchardy
ACC67219, ACC67220, ACC67221, ACC67222, ACC67223, ACC67224, ACC67225, ACC67226, ACC67227... |
Is metformin use associated with low mortality in patients with type 2 diabetes mellitus hospitalized for COVID-19? a multivariable and propensity score-adjusted meta-analysis
BackgroundCoronavirus disease 2019 (COVID-19) is a new pandemic that the entire world is facing since December of 2019. Increasing evidence has... |
Retailer opinions about and compliance with family smoking prevention and tobacco control act point of sale provisions: a survey of tobacco retailers
Background: The objectives of this study were to document retailer opinions about tobacco control policy at the point of sale (POS) and link these opinions with store le... |
Pre-impact fall detection
BackgroundFalls are a major safety concern, especially in older people. Approximately 28-35 % of people aged of 65 and above fall at least once every year[4,10,36]. In the US, 70 % of all emergency department visits by people over the age of 75 years were related to falls[39]. The consequence... |
Shewanella knowledgebase: integration of the experimental data and computational predictions suggests a biological role for transcription of intergenic regions
Shewanellae are facultative g-proteobacteria whose remarkable respiratory versatility has resulted in interest in their utility for bioremediation of heavy met... |
Utilizing the Second-Meal Effect in Type 2 Diabetes: Practical Use of a Soya-Yogurt Snack
OBJECTIVE -To evaluate the effect of a prebreakfast high-protein snack upon postbreakfast hyperglycemia.RESEARCH DESIGN AND METHODS -We studied 10 men and women with dietand/or metformin-controlled type 2 diabetes. Metabolic chan... |
Understanding the Current Health Services Research Workforce and Maximizing its Future
In 2016, AcademyHealth continued its longstanding efforts to understand the health services research (HSR) workforce, to inform its changing needs through the commissioning of several papers and an invitational conference. This pape... |
Cost‐effectiveness of second‐line empagliflozin versus liraglutide for type 2 diabetes in the United States
Aim: To estimate the cost-effectiveness of sequential use of the sodium-glucose cotransporter-2 inhibitor empagliflozin and glucagon-like peptide-1 receptor agonist liraglutide after metformin in patients with t... |
Hospital case volume and outcomes for proximal femoral fractures in the USA: an observational study
Objective: To explore whether older adults with isolated hip fractures benefit from treatment in highvolume hospitals.Design: Population-based observational study. Setting: All acute hospitals in California, USA. Partic... |
Association between pre-diabetes and microvascular and macrovascular disease in newly diagnosed type 2 diabetes
Objective The associated risk of vascular disease following diagnosis of type 2 diabetes in people previously identified as having pre-diabetes in real-world settings is unknown. We examined the presence of ... |
mRNA expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 and its significance in pancreatic cancer
Background: The aim of this study is to investigate the expressions of somatostatin receptor (SSTR), SSTR-2, SSTR-3, and SSTR-5, in pancreatic tissue and non-cancerous tissue and elucidate their clini... |
Alterations of RET, Oncogene in Human Adrenal Tumors
Previous studies have revealed specific activations of the RET oncogene in multiple endocrine neoplasia type 2 (MEN 2) and thyroid tumors. To understand the role of the RET proto-oncogene activation in sporadic adrenal tumors, we analyzed the alterations of the RET ... |
Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA
In Mycobacterium tuberculosis, the genes Rv1954A-Rv1957 form an operon that includes Rv1955 and Rv1956 which encode the HigB toxin and the HigA antitoxin res... |
The Utilization of National Tobacco Cessation Services among Female Smokers and the Need for a Gender-Responsive Approach
# Introduction
Worldwide, there have been more countries that have achieved a significantly greater decrease in smoking prevalence among men than women. Although the prevalence of male tobacco us... |
An Open‐Label Study to Assess the Effect of Itraconazole and Rifampin on Parsaclisib Pharmacokinetics When Administered Orally in Healthy Participants
Parsaclisib, a selective, potent phosphatidylinositol 3-kinase delta inhibitor being developed for the treatment of cancer and autoimmune diseases, is primarily metabol... |
A Review of Biomonitoring of Phthalate Exposures
Phthalates (diesters of phthalic acid) are widely used as plasticizers and additives in many consumer products. Laboratory animal studies have reported the endocrine-disrupting and reproductive effects of phthalates, and human exposure to this class of chemicals is a co... |
Extracellular Vesicles As Modulators of Tumor Microenvironment and Disease Progression in Glioma
Diffuse gliomas are lethal tumors of the central nervous system (CNS) characterized by infiltrative growth, aggressive nature, and therapeutic resistance. The recent 2016 WHO classification for CNS tumors categorizes diffu... |
In How Many Ways is the Approximate Number System Associated with Exact Calculation?
The approximate number system (ANS) has been consistently found to be associated with math achievement. However, little is known about the interactions between the different instantiations of the ANS and in how many ways they are rela... |
Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases
# Introduction
Focal studies of hepatic secretion led to the critical analysis and understanding of bile and its circulation connecting the liver and intestine (1). Bile acids (BAs) are heterogenous compounds whose chemical and amphipathic properties ... |
VEGFR-3 and CXCR4 as predictive markers for treatment with fluorouracil, leucovorin plus either oxaliplatin or cisplatin in patients with advanced esophagogastric cancer: a comparative study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
Background: Combination of fluoropyrimidines and a platinum derivative... |
Determining the Population Frequency of the CFHR3/CFHR1 Deletion at 1q32
In this study we have used multiplex ligation-dependent probe amplification (MLPA) to measure the copy number of CFHR3 and CFHR1 in DNA samples from 238 individuals from the UK and 439 individuals from the HGDP-CEPH Human Genome Diversity Cell Li... |
Bio-grout based on microbially induced sand solidification by means of asparaginase activity
Bio-grout, a new ground improvement method, has been recently developed to improve the mechanical properties, decrease the permeability of porous materials, reinforce or repair cementitious materials and modify the properties ... |
Implementation of a temperature bundle improves admission hypothermia in very-low-birth-weight infants in China: a multicentre study
Background Hypothermia is a common problem that is associated with increased mortality and morbidity among preterm infants, especially in China. The objective of this study was to evalua... |
Acute cardiac injury events ≤30 days after laboratory-confirmed influenza virus infection among U.S. veterans, 2010–2012
Background: Cardiac injury is a known potential complication of influenza infection. Because U.S. veterans cared for at the U.S. Department of Veterans Affairs are older and have more cardiovascular... |
Sample-size determination for the Bayesian t test and Welch’s test using the approximate adjusted fractional Bayes factor
When two independent means μ 1 and μ 2 are compared, H 0 : μ 1 = μ 2 , H 1 : μ 1 = μ 2 , and H 2 : μ 1 > μ 2 are the hypotheses of interest. This paper introduces the R package SSDbain, which can b... |
Fluoride contributes to the shaping of microbial community in high fluoride groundwater in Qiji County, Yuncheng City, China
As a toxic element, excessive amounts of fluoride in environment can be harmful because of its antimicrobial activity, however little is known about the relationship between fluoride and the bac... |
Assessing heart rate variability in type 1 diabetes mellitus—Psychosocial stress a possible confounder
## | introduc ti on
Reduced heart rate variability (HRV) as a sign of cardiac autonomic dysfunction has been found to be an independent predictor of death and of cardiovascular events, in individuals with diabetes ... |
Barriers and Facilitators to the International Implementation of Standardized Outcome Measures in Clinical Cleft Practice
Objective: To identify barriers and facilitators to international implementation of a prospective system for standardized outcomes measurement in cleft care.Design: Cleft teams that have implemente... |
COVID-19 outbreak in an elderly care home: Very low vaccine effectiveness and late impact of booster vaccination campaign
a b s t r a c tBackground: Elderly people in long-term care facilities (LTCF) are at higher risk for (severe) COVID-19, yet evidence of vaccine effectiveness (VE) in this population is scarce. In N... |
No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
Citation: Dziedzic, E.A.; Gąsior, J.S.; Tuzimek, A.; Paleczny, J.; Kwaśny, M.; Dąbrowski, M.; Jankowski, P. No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and N... |
Chemical Characteristics and Antioxidant Properties of Crude Water Soluble Polysaccharides from Four Common Edible Mushrooms
Four crude water soluble polysaccharides, CABP, CAAP, CFVP and CLDP, were isolated from common edible mushrooms, including Agaricus bisporus, Auricularia auricula, Flammulina velutipes and Lenti... |
Epidermolysis bullosa acquisita as an adverse effect from rituximab therapy
Rationale: Rituximab is a monoclonal antibody directed against B cells and is a first-line agent for the treatment of B cell lymphoma and a second-line agent for the treatment of idiopathic thrombocytopenic purpura (ITP). It has also been used... |
The association between vertebrobasilar insufficiency and the risk of dementia: a nationwide register-based retrospective cohort study in Taiwan
BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (http://bmjopen.bmj.com/site/about/resources/check... |
Severe Acute Pancreatitis with Candida Endophthalmitis
Severe acute pancreatitis (SAP) is a risk factor for candidemia. We report a case of candida endophthalmitis in a 67-year-old man who was admitted to a hospital due to SAP with poorly controlled diabetes. After treatment for SAP, he was diagnosed with candidemia a... |
Changes in Physical Activity Following a Genetic-Based Internet-Delivered Personalized Intervention: Randomized Controlled Trial (Food4Me)
Background: There is evidence that physical activity (PA) can attenuate the influence of the fat mass-and obesity-associated (FTO) genotype on the risk to develop obesity. However,... |
Interleukin-17 promotes proliferation, migration, and invasion of trophoblasts via regulating PPAR-γ/RXR-α/Wnt signaling
To investigate the effect of Interleukin 17 (IL-17) on the invasive capacity of trophoblast cells and the underlying mechanism, we collected placental tissues samples from pregnant women with preecl... |
HPV32‐related Heck’s disease in a chronic graft‐versus‐host disease patient with long‐term successful KTP laser treatment: A rare case report
[bib_ref] In situ detection of human papillomavirus types 13 and 32 in focal..., Henke [/bib_ref] [bib_ref] A case report of focal epithelial hyperplasia (Heck's disease) with ... |
Network meta-analysis of infliximab biosimilars for the treatment of rheumatoid arthritis
A c c e p t e d M a n u s c r i p t Purpose. This article assesses the relative efficacy and safety of infliximab biosimilars in treatment of patients with rheumatoid arthritis (RA).Methods.A frequentist, random-effects network m... |
The reciprocal influences of prognosis between two types of surgical interventions and early breast cancer patients with diverse luminal subtypes
Background: To investigate and compare the effects of breast-conserving therapy (BCT) and mastectomy on the disease recurrence and long-term survival in early-stage luminal ... |
Toluidine blue versus frozen section for assessment of mucosal tumor margins in oral squamous cell carcinoma
Background: When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possib... |
Metal-Dependent DNA Recognition and Cell Internalization of Designed, Basic Peptides
A fragment of the DNA basic region (br) of the GCN4 bZIP transcription factor has been modified to include two His residues at designed i and i+4 positions of its N-terminus. The resulting monomeric peptide (brHis 2 ) does not bind to... |
Good Clinical Teachers Likely to be Specialist Role Models: Results from a Multicenter Cross-Sectional Survey
Context: Medical educational reform includes enhancing role modelling of clinical teachers. This requires faculty being aware of their role model status and performance. We developed the System for Evaluation ... |
Cervicofacial nocardiosis in children
# Discussion
Primary cutaneous nocardiosis and the nocardial lymphocutaneous syndrome mimicking sporotrichosis have been described in adult patients. 6-~ Among children, however, primary nocardial skin and lymph node infections have been reported infrequently, 3-5 and Nocardia i... |
Orchestrated translation specializes dinoflagellate metabolism three times per day
[bib_ref] Phased protein synthesis at several circadian times does not change protein levels..., Markovic [/bib_ref]
## Figure s7: comparison of rna levels and rpf read counts.
A heat map comparing RNA levels (determined from a previ... |
Structure–function characterization of the mono- and diheme forms of MhuD, a noncanonical heme oxygenase from Mycobacterium tuberculosis
## Edited by ruma banerjee
MhuD is a noncanonical heme oxygenase (HO) from Mycobacterium tuberculosis (Mtb) that catalyzes unique heme degradation chemistry distinct from canonical... |
Genetic Interaction Analysis of TCF7L2 for Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer
Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription fac... |
DE-STRESS: a user-friendly web application for the evaluation of protein designs
De novo protein design is a rapidly growing field, and there are now many interesting and useful examples of designed proteins in the literature. However, most designs could be classed as failures when characterised in the lab, usually as... |
High abundance of virulence gene homologues in marine bacteria
Marine bacteria can cause harm to single-celled and multicellular eukaryotes. However, relatively little is known about the underlying genetic basis for marine bacterial interactions with higher organisms. We examined whole-genome sequences from a large nu... |
The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was under... |
Fabrication of a Cranial Prosthesis Combined with an Ocular Prosthesis Using Rapid Prototyping: A Case Report
Rapid prototyping (RP) is a technique of manufacturing parts by the additive layer manufacturing technology; where, a three-dimensional (3D) model created in a computer aided design (CAD) system is sectioned i... |
Spontaneous tumor lysis syndrome in a patient with advanced gastric adenocarcinoma: a case report
Tumor lysis syndrome (TLS) is an oncologic emergency that usually occurs after initial treatment of a malignant tumor. It manifests as hyperuricaemia, hyperkalaemia, hyperphosphataemia and hypocalcaemia, ultimately result... |
Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
BACKGROUND/OBJECTIVES: Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin se... |
Transient mydriasis in toxoplasmosis retinochoroiditis
A B S T R A C TPurpose: To report a case of transient anisocoria and mydriasis in a 14 year old boy with toxoplasmosis retinochoroiditis. Observation: The patient presented with panuveitis and mydriasis which persisted for 18 days and spontaneously resolved. Concl... |
Constructing Endophenotypes of Complex Diseases Using Non-Negative Matrix Factorization and Adjusted Rand Index
Complex diseases are typically caused by combinations of molecular disturbances that vary widely among different patients. Endophenotypes, a combination of genetic factors associated with a disease, offer a ... |
Quantifying Reversible Surface Binding via Surface-Integrated Fluorescence Correlation Spectroscopy
## Si-fcs image acquisition
Unless stated otherwise, SI-FCS analysis was performed on image sequences of 64x64 pixel (4x4 binning) and for comparable analysis resized to the camera resolution of 256x256 pixels. Image ... |
Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications
Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodiu... |
Genomic Characterization of Two Novel RCA Phages Reveals New Insights into the Diversity and Evolution of Marine Viruses
Viruses are the most abundant living entities in marine ecosystems, playing critical roles in altering the structure and function of microbial communities and driving ocean biogeochemistry. Phages t... |
The experience of loneliness among young people with depression: a qualitative meta-synthesis of the literature
Background: Young people have a higher prevalence of loneliness than other age groups, and they are also at risk of depression. Quantitative studies describe a bidirectional association between loneliness an... |
Probing helicity and the topological origins of helicity via non-local Hanbury-Brown and Twiss correlations
Quantum Hall edge modes are chiral while quantum spin Hall edge modes are helical. However, unlike chiral edge modes which always occur in topological systems, quasi-helical edge modes may arise in a trivial ins... |
Energy, Waves, and Forces in Bilateral Fracture of the Femoral Necks: Two Case Presentations and Updated Critical Review
# Introduction
Bilateral femoral neck fracture has long been subject to investigation, owing to its rare occurrence and the multiple causes and mechanisms supposedly responsible for its incidence.... |
Detection of Cryptosporidium parvum in Environmental Soil and Vegetables
# Introduction
Cryptosporidium parvum is a protozoan parasite that causes cryptosporidiosis which is characterized by enteritis of watery diarrhea. Being a zoonotic disease, it can be transmitted between humans and animals. Numerous cryptospori... |
The distribution and relative ecological roles of autotrophic and heterotrophic diazotrophs in the McMurdo Dry Valleys, Antarctica
The McMurdo Dry Valleys (MDV) in Antarctica harbor a diverse assemblage of mat-forming diazotrophic cyanobacteria that play a key role in nitrogen cycling. Prior research showed that heter... |
rs4246215 is targeted by hsa-miR1236 to regulate FEN1 expression but is not associated with Fuchs’ endothelial corneal dystrophy
Fuchs' Endothelial Corneal Dystrophy (FECD) is a genetically complex disorder that affects individuals above 40 years of age; molecular pathogenesis of its associated genes is poorly underst... |
A Review on the Use of Impedimetric Sensors for the Inspection of Food Quality
This paper exhibits a thorough review of the use of impedimetric sensors for the analysis of food quality. It helps to understand the contribution of some of the major types of impedimetric sensors that are used for this application. The de... |
Genome organization and DNA accessibility control antigenic variation in trypanosomes
## For bayesian analysis, information on the choice of priors and markov chain monte carlo settings
For hierarchical and complex designs, identification of the appropriate level for tests and full reporting of outcomes Estimates of... |
Development and external validation of prognostic models for COVID-19 to support risk stratification in secondary care
Objectives Existing UK prognostic models for patients admitted to the hospital with COVID-19 are limited by reliance on comorbidities, which are under-recorded in secondary care, and lack of imaging d... |
The Inactivation by Curcumin-Mediated Photosensitization of Botrytis cinerea Spores Isolated from Strawberry Fruits
# Introduction
Strawberries are one of the most popular fruits consumed worldwide, with global production in excess of 9M tons per annum and an estimated annual production value of USD 18B worldwide . ... |
Occurrence of and factors influencing elderly homebound in Chinese urban community
Studies on the occurrence of homebound and the factors influencing it are available. However, the study of community homebound in China is still in its preliminary stage. No previous studies about this issue are available. This study ai... |
Lemierre syndrome: remember the forgotten disease.
# Introduction
Lemierre syndrome, described as the 'forgotten disease'' although very uncommon2 is an infection-related syndrome which is important to diagnose accurately since its mortality may be high.
CASEREPORT A 14-yearoldgirl,withahistory of chronic mastoiditi... |
Synthesis and Electrochemical Proprieties of Novel Unsymmetrical Bis-Tetrathiafulvalenes and Electrical Conductivity of Their Charge Transfer Complexes with Tetracyanoquinodimethane (TCNQ)
The synthesis and properties of a series of bis-tetrathiafulvalenes (bis-TTFs) containing nitrophenyl, aminophenyl or dimethylamin... |
The knowledge and attitudes of general practitioners to the assessment and management of pain in people with dementia
Background: Pain in people with dementia is underdiagnosed and undertreated. General practitioners (GPs) play a pivotal role in dementia care but their perspectives on pain in people with dementia rema... |
Access to basic drinking water services, safe water storage, and household water treatment practice in rural communities of northwest Ethiopia
Protecting water from cross contamination at source and point of use is an important strategy to improve water quality. However, water safety measures at the source and point o... |
Impact of a soy drink on climacteric symptoms: an open-label, crossover, randomized clinical trial
Objectives: The objective of this study is to evaluate the effects of a soy drink with a high concentration of isoflavones (ViveSoy Õ ) on climacteric symptoms.Methods: An open-label, controlled, crossover clinical trial... |
Focal vitreomacular traction: Resolution after ocular massage
A B S T R A C TPurpose: Vitreomacular traction (VMT) is a relatively common ocular disorder that may distort the foveal structure causing visual symptoms. The influence of ocular massage (OM) on this condition has not been considered yet. We aim to report c... |
Gynecomastia: A Rare Adverse Effect of Methylphenidate in an Adolescent Boy
Gynecomastia is a benign condition developing in association with localized fat deposition and glandular tissue proliferation in the breast in males, and characterized by breast growth. Drug is one of the most important factors in the etiology... |
Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
Citation: Ribeiro Pereira, P.; Bertozzi de Aquino Mattos, É.; Nitzsche Teixeira Fernandes Corrêa, A.C.; Afonso Vericimo, M.; Margaret Flosi Paschoalin, V. Anticancer and Immunomodulatory Benefits of Taro (Colocas... |
Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine
Mesenchymal stem/stromal cells (MSCs) have been widely studied in the field of regenerative medicine for applications in the treatment of several disease settings. The therapeutic potential ... |
Current methods for the assessment of skin microcirculation: Part 2
A b s t r a c tMicrocirculation accounts for about 99% of blood vessels in adults and mediates between the arterial and venous parts of the cardiovascular system, both structurally and functionally. Skin microcirculation consists of two vascular plexu... |
Femoral anteversion: significance and measurement
## | b iomechanic al s ig nific an ce of fn a
A change in FNA affects the position of the trochanter and therefore the line of action of the muscles surrounding that region.
Regional torsional changes along the femur also result in a change of lever arms. A higher FN... |
Multiplexed protein profiling by sequential affinity capture
Antibody microarrays enable parallelized and miniaturized analysis of clinical samples, and have proven to provide novel insights for the analysis of different proteomes. However, there are concerns that the performance of such direct labeling and single ant... |
Pattern of psychiatric in-patient admissions in Al Ain, United Arab Emirates
## Global echoes pattern of psychiatric in-patient admissions in al ain, united arab emirates
Karim Abdel Aziz,Dina Aly El-Gabry,Mouza Al-Sabousi,Ghanem Al-Hassani,Moataz M. Ragheb,Mohamed Elhassan Elamin,Mohamed Abdel-Maksoud,Emmanuel Stip... |
Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
# Introduction
Ichthyoses represent a large heterogenous group of hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin, va... |
Assessment of disease specific immune responses in enteric diseases using dried blood spot (DBS)
BackgroundBlood collection, transportation and storage remain a problem in countries where infrastructure, laboratory facilities and skilled manpower are scarce. This limits evaluation of immune responses in natural infect... |
Heavily Armed Ancestors: CRISPR Immunity and Applications in Archaea with a Comparative Analysis of CRISPR Types in Sulfolobales
Prokaryotes are constantly coping with attacks by viruses in their natural environments and therefore have evolved an impressive array of defense systems. Clustered Regularly Interspaced Sho... |
Health and nutritional aspects of sustainable diet strategies and their association with environmental impacts: a global modelling analysis with country-level detail
Background Sustainable diets are intended to address the increasing health and environmental concerns related to food production and consumption. Althoug... |
A Case Report of Infective Endocarditis with Failure of the Empirical Treatment—Q Fever Endocarditis Diagnosed by Metagenomic Next-Generation Sequencing
# Introduction
Q fever is a naturally occurring epidemic disease caused by the Coxiella burnetii (C. burnetii) infection. The hosts of C. burnetii include mammals, ... |
DegNorm: normalization of generalized transcript degradation improves accuracy in RNA-seq analysis
RNA degradation affects RNA-seq quality when profiling transcriptional activities in cells. Here, we show that transcript degradation is both gene-and sample-specific and is a common and significant factor that may bias ... |
Dark Plasmonic Breathing Modes in Silver Nanodisks
The experimental EEL maps shown inFigure 1bof the main part were acquired with the STEM-EELS technique (STEM scanning transmission electron microscope, EELS electron energy loss spectroscopy), scanning a 200 keV electron beam over the region of interest and taking EEL... |
Chronic Thromboembolic Pulmonary Hypertension: A Comprehensive Review and Multidisciplinary Approach to Surgical Treatment
Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed and undertreated sequelae of acute pulmonary embolism. In this comprehensive review, we provide an introductory overview ... |
Beyond breast density: a review on the advancing role of parenchymal texture analysis in breast cancer risk assessment
Background: The assessment of a woman's risk for developing breast cancer has become increasingly important for establishing personalized screening recommendations and forming preventive strategies. S... |
Variation in KCNQ1 is associated with therapeutic response to sulphonylureas
Background:We aimed to analyse quantitative effects of treatment with sulphonylurea in addition to metformin on parameters of glycemic control in relation to KCNQ1 genotypes, and to identify factors predictive for the response to sulphonylure... |
Enhancement, ethics and society: towards an empirical research agenda for the medical humanities and social sciences
For some time now, bioethicists have paid close attention to issues associated with 'enhancement'; specifically, the appropriate use and regulation of substances and artefacts understood by some to impr... |
HIV Testing Implementation in Two Urban Cities: Practice, Policy, and Perceived Barriers
Background: Although funding has supported the scale up of routine, opt-out HIV testing in the US, variance in implementation mechanisms and barriers in high-burden jurisdictions remains unknown.Methods: We conducted a survey of h... |
Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide
In this manuscript, Ng et al. aim at engineering an artificial barrier in vitro to mimic what happened in the native nuclear pore by using extracted GLFG12mer peptides and then testing the selectivity of the GLFG-assembl... |
Glomerulonephritis in Youth With Dystrophic Epidermolysis Bullosa
# Introduction
E pidermolysis bullosa (EB) is a rare group of genetic conditions involving mutations in genes such as COL7A1 that encode structural proteins required to maintain skin integrity. These mutations lead to skin fragility and subsequent non... |
Global Origin of Mycobacterium tuberculosis in the Midlands, UK
DNA fi ngerprinting data for 4,207 Mycobacterium tuberculosis isolates were combined with data from a computer program (Origins). Largest population groups were from England (n = 1,031) and India (n = 912), and most prevalent strains were the Euro-America... |
Effects of 5-Aminolevulinic Acid as a Supplement on Animal Performance, Iron Status, and Immune Response in Farm Animals: A Review
Simple Summary: 5-aminolevulinic acid is an amino acid that promotes the formation of heme-an essential constituent of hemoglobin. It has been recently used as a novel feed supplement to e... |
Model‐based meta‐analysis of changes in circulatory system physiology in patients with chronic heart failure
This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly ... |
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