Search is not available for this dataset
article stringlengths 4.36k 149k | summary stringlengths 32 3.35k | section_headings listlengths 1 91 | keywords listlengths 0 141 | year stringclasses 13
values | title stringlengths 20 281 |
|---|---|---|---|---|---|
CLK-2/TEL2 is essential for viability from yeasts to vertebrates , but its essential functions remain ill defined . CLK-2/TEL2 was initially implicated in telomere length regulation in budding yeast , but work in Caenorhabditis elegans has uncovered a function in DNA damage response signalling . Subsequently , DNA dama... | PI3K-related protein kinases ( PIKKs ) ATM and ATR are essential upstream components of DNA damage signalling pathways , while TOR-1 acts as a nutrient sensor . CLK-2/TEL2 is a conserved gene initially implicated in budding yeast telomere length regulation and uncovered in the same genetic screen as the yeast TEL1 ATM ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Material",
"and",
"Methods"
] | [
"cell",
"biology/cell",
"growth",
"and",
"division",
"cell",
"biology",
"genetics",
"and",
"genomics/gene",
"function",
"genetics",
"and",
"genomics/animal",
"genetics"
] | 2009 | Functional Dissection of Caenorhabditis elegans CLK-2/TEL2 Cell Cycle Defects during Embryogenesis and Germline Development |
Buruli ulcer ( BU ) is a skin disease caused by Mycobacterium ulcerans . Its exact mode of transmission is not known . Previous studies have identified demographic , socio-economic , health and hygiene as well as environment related risk factors . We investigated whether the same factors pertain in Suhum-Kraboa-Coaltar... | Mycobacterium ulcerans is the causative agent of Buruli ulcer ( BU ) which affects the skin , can lead to extensive ulceration , and often results in disabilities . The exact mode of transmission of the disease is still unknown . Previous studies have identified demographic , socio-economic , health and hygiene , as we... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"and",
"health",
"sciences"
] | 2014 | Risk Factors for Buruli Ulcer in Ghana—A Case Control Study in the Suhum-Kraboa-Coaltar and Akuapem South Districts of the Eastern Region |
DNA replication programs have been studied extensively in yeast and animal systems , where they have been shown to correlate with gene expression and certain epigenetic modifications . Despite the conservation of core DNA replication proteins , little is known about replication programs in plants . We used flow cytomet... | During growth and development , all plants and animals must replicate their DNA . This process is regulated to ensure that all sequences are completely and accurately replicated and is limited to S phase of the cell cycle . In the cell , DNA is packaged with histone proteins into chromatin , and both DNA and histones a... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"genetics",
"and",
"genomics/genomics",
"molecular",
"biology/dna",
"replication",
"molecular",
"biology/chromatin",
"structure",
"molecular",
"biology/histone",
"modification",
"biochemistry/replication",
"and",
"repair",
"molecular",
"biology/dna",
"methylation",
"genetics",
... | 2010 | Arabidopsis thaliana Chromosome 4 Replicates in Two Phases That Correlate with Chromatin State |
Tapeworm ( cestode ) infections occur worldwide even in developed countries and globalization has further complicated the epidemiology of such infections . Nonetheless , recent epidemiological data on cestode infections are limited . Our objectives were to elucidate the clinical characteristics and epidemiology of diph... | Tapeworm ( cestode ) infections occur worldwide even in developed countries . Causative species of cestode infections differ significantly depending on the geographical areas and globalization has further complicated the epidemiology of such infections . Nonetheless , recent epidemiological data on cestode infections a... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"invertebrates",
"beef",
"medicine",
"and",
"health",
"sciences",
"fish",
"pathology",
"and",
"laboratory",
"medicine",
"cestodes",
"helminths",
"japan",
"geographical",
"locations",
"diet",
"vertebrates",
"parasitic",
"diseases",
"animals",
"animal",
"products",
"ostei... | 2018 | Clinical characteristics and epidemiology of intestinal tapeworm infections over the last decade in Tokyo, Japan: A retrospective review |
The Republic of Haiti is one of only several countries in the Western Hemisphere in which canine rabies is still endemic . Estimation methods have predicted that 130 human deaths occur per year , yet existing surveillance mechanisms have detected few of these rabies cases . Likewise , canine rabies surveillance capacit... | The Republic of Haiti has highest estimated burden of human rabies in the Western Hemisphere , at 130 estimated human deaths annually . Rabies surveillance systems in the majority of the developing world , including Haiti , are ineffective , resulting in underreporting of cases and contributing to the further neglect o... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [] | 2015 | Establishment of a Canine Rabies Burden in Haiti through the Implementation of a Novel Surveillance Program |
The sexually transmitted bacterium Neisseria gonorrhoeae has developed resistance to all antibiotic classes that have been used for treatment and strains resistant to multiple antibiotic classes have evolved . In many countries , there is only one antibiotic remaining for empirical N . gonorrhoeae treatment , and antib... | More and more infectious disease treatments fail because the causative pathogens are resistant to the drugs used for treatment . For the treatment of Neisseria gonorrhoeae , a sexually transmitted bacterium , drug resistance is a particularly big problem: there is only a single antibiotic left that is recommended for t... | [
"Abstract",
"Introduction",
"Results",
"Discussion"
] | [
"antimicrobials",
"medicine",
"and",
"health",
"sciences",
"pathology",
"and",
"laboratory",
"medicine",
"pathogens",
"drugs",
"microbiology",
"neisseria",
"gonorrhoeae",
"antibiotic",
"resistance",
"probability",
"distribution",
"mathematics",
"antibiotics",
"sexually",
"t... | 2016 | Antibiotic-Resistant Neisseria gonorrhoeae Spread Faster with More Treatment, Not More Sexual Partners |
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts . What is less clear are the factors influencing the distribution of virus-specific lineages . Japanese encephalitis virus ( JEV ) is the most important ... | Although Japanese encephalitis virus ( JEV ) is a major cause of death and disability throughout tropical and temperate Asia , little is known about the evolution , geographical distribution and epidemiology of the five JEV genotypes ( genetically distinct groups ) . To address this gap in our knowledge , we performed ... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"infectious",
"diseases",
"evolutionary",
"ecology",
"ecology",
"neglected",
"tropical",
"diseases",
"biology",
"japanese",
"encephalitis"
] | 2013 | Phylogeography of Japanese Encephalitis Virus: Genotype Is Associated with Climate |
Neurocysticercosis , infection of the brain with larvae of Taenia solium ( pork tapeworm ) , is one of several forms of human cysticercosis caused by this organism . We investigated the role of albendazole and praziquantel in the treatment of patients with parenchymal neurocysticercosis by performing a meta-analysis of... | Neurocysticercosis is a parasitic disease caused by the pork tapeworm , Taenia solium , when the larval form of the parasite lodges in the central nervous system . This disease is most commonly found among members of agricultural societies with poor sanitary conditions and economies based on breeding livestock ( especi... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases/infectious",
"diseases",
"of",
"the",
"nervous",
"system",
"infectious",
"diseases/neglected",
"tropical",
"diseases",
"neurological",
"disorders/infectious",
"diseases",
"of",
"the",
"nervous",
"system",
"infectious",
"diseases/helminth",
"infections"... | 2008 | Albendazole versus Praziquantel in the Treatment of Neurocysticercosis: A Meta-analysis of Comparative Trials |
Understanding the host immune response during cryptococcal meningitis ( CM ) is of critical importance for the development of immunomodulatory therapies . We profiled the cerebrospinal fluid ( CSF ) immune-response in ninety patients with HIV-associated CM , and examined associations between immune phenotype and clinic... | Cryptococcal meningitis is a severe opportunistic infection , estimated to kill several hundred thousand HIV-infected individuals each year . One of the factors contributing to this high death toll is the inadequacy of antifungal treatments . As few novel antifungal drugs are being developed , several groups have start... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [] | 2015 | Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis |
The cysteine desulfurase IscS is a highly conserved master enzyme initiating sulfur transfer via persulfide to a range of acceptor proteins involved in Fe-S cluster assembly , tRNA modifications , and sulfur-containing cofactor biosynthesis . Several IscS-interacting partners including IscU , a scaffold for Fe-S cluste... | Sulfur is incorporated into the backbone of almost all proteins in the form of the amino acids cysteine and methionine . In some proteins , sulfur is also present as iron–sulfur clusters , sulfur-containing vitamins , and cofactors . What's more , sulfur is important in the structure of tRNAs , which are crucial for tr... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"cell",
"biology/microbial",
"growth",
"and",
"development",
"microbiology/microbial",
"growth",
"and",
"development",
"biochemistry/macromolecular",
"assemblies",
"and",
"machines"
] | 2010 | Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions |
Tomato yellow leaf curl virus ( TYLCV ) is a devastating disease of tomato ( Solanum lycopersicum ) that can be effectively controlled by the deployment of resistant cultivars . The TYLCV-resistant line TY172 carries a major recessive locus for TYLCV resistance , designated ty-5 , on chromosome 4 . In this study , the ... | Tomato is one of the most important food crops worldwide , providing phytonutrients and color to our diet . Tomato yellow leaf curl virus ( TYLCV ) is one of the most devastating viruses of cultivated tomatoes and a key limiting factor to tomato production in major tomato-growing areas . The management of TYLCV is diff... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2015 | A Novel Route Controlling Begomovirus Resistance by the Messenger RNA Surveillance Factor Pelota |
The objective of this study was to assess the validity of the new dengue classification proposed by the World Health Organization ( WHO ) in 2009 and to develop pragmatic guidelines for case triage and management . This retrospective study involved 357 laboratory-confirmed cases of dengue infection diagnosed at King Ab... | Dengue fever , the most prevalent arthropod-borne viral disease in humans , has been conventionally classified into four main categories: non-classical , classical , dengue hemorrhagic fever , and dengue shock syndrome . Several studies reported lack of correlation between the categories of the conventional classificat... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"blood",
"cells",
"cognitive",
"science",
"medicine",
"and",
"health",
"sciences",
"body",
"fluids",
"pathology",
"and",
"laboratory",
"medicine",
"vomiting",
"tropical",
"diseases",
"neuroscience",
"physiological",
"processes",
"cognitive",
"neuroscience",
"signs",
"an... | 2019 | Assessment of the new World Health Organization's dengue classification for predicting severity of illness and level of healthcare required |
Among the most common human congenital anomalies , cleft lip and palate ( CL/P ) affects up to 1 in 700 live births . MicroRNA ( miR ) s are small , non-coding RNAs that repress gene expression post-transcriptionally . The miR-17-92 cluster encodes six miRs that have been implicated in human cancers and heart developme... | CL/P are very common birth defects in humans . The genetic mechanism underlying CL/P pathogenesis is poorly understood . MiRs , small non-coding RNAs that function to post-transcriptionally regulate gene expression , have been identified as pivotal modulators of various developmental events and diseases . To date , the... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2013 | MicroRNA-17-92, a Direct Ap-2α Transcriptional Target, Modulates T-Box Factor Activity in Orofacial Clefting |
Anthropogenic land use may influence transmission of multi-host vector-borne pathogens by changing diversity , relative abundance , and community composition of reservoir hosts . These reservoir hosts may have varying competence for vector-borne pathogens depending on species-specific characteristics , such as life his... | Understanding how host species influence vector-borne pathogen transmission in anthropogenically disturbed landscapes is important to predicting and preventing disease transmission . This study evaluates how host diversity , anthropogenic land use change , and host life history influence vector- borne multihost pathoge... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"evolutionary",
"ecology",
"microbiology",
"parasitic",
"diseases",
"neglected",
"tropical",
"diseases",
"veterinary",
"science",
"infectious",
"diseases",
"veterinary",
"diseases",
"zoonotic",
"diseases",
"biology",
"vectors",
"and",
"hosts",
"community",
"ec... | 2012 | Host Life History Strategy, Species Diversity, and Habitat Influence Trypanosoma cruzi Vector Infection in Changing Landscapes |
Nanoparticles introduced in living cells are capable of strongly promoting the aggregation of peptides and proteins . We use here molecular dynamics simulations to characterise in detail the process by which nanoparticle surfaces catalyse the self-assembly of peptides into fibrillar structures . The simulation of a sys... | Protein misfolding and aggregation are associated with a wide variety of human disorders , which include Alzheimer's and Parkinson's diseases and late onset diabetes . It has been recently realised that the process of aggregation may be triggered by the presence of nanoparticles . We use here molecular dynamics simulat... | [
"Abstract",
"Introduction",
"Results",
"and",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"biophysics",
"computational",
"biology"
] | 2009 | A Condensation-Ordering Mechanism in Nanoparticle-Catalyzed Peptide Aggregation |
Rift Valley fever virus ( RVFV ) belongs to the family of Phenuiviridae within the order of Bunyavirales . The virus may cause fatal disease both in livestock and humans , and therefore , is of great economical and public health relevance . In analogy to the influenza virus polymerase complex , the bunyavirus L protein... | Rift Valley fever virus ( RVFV ) is endemic to sub-Saharan Africa and the Arabian Peninsula and leads to abortions in and death of ruminants . The virus can also be transmitted to humans causing febrile illness up to hemorrhagic fever with the possibility of fatal outcome . As there is currently no human vaccine or spe... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"medicine",
"and",
"health",
"sciences",
"rift",
"valley",
"fever",
"virus",
"pathology",
"and",
"laboratory",
"medicine",
"pathogens",
"microbiology",
"viral",
"structure",
"orthomyxoviruses",
"viruses",
"rna",
"viruses",
"protein",
"structure",
"bunyaviruses",
"resear... | 2019 | Structure of a functional cap-binding domain in Rift Valley fever virus L protein |
Segmentation of the vertebrate body axis is initiated through somitogenesis , whereby epithelial somites bud off in pairs periodically from the rostral end of the unsegmented presomitic mesoderm ( PSM ) . The periodicity of somitogenesis is governed by a molecular oscillator that drives periodic waves of clock gene exp... | Vertebrate animals generate their segmented body plan during embryogenesis . These embryonic segments , or somites , form one after another from tissue at the tail end of the embryo in a highly regulated process controlled by a molecular oscillator . This oscillator drives the expression of a group of genes in this tis... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Material",
"and",
"Methods"
] | [
"developmental",
"biology/embryology",
"developmental",
"biology",
"developmental",
"biology/morphogenesis",
"and",
"cell",
"biology",
"developmental",
"biology/pattern",
"formation",
"developmental",
"biology/cell",
"differentiation",
"developmental",
"biology/molecular",
"develop... | 2009 | Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites |
Spatiotemporal pattern formation in neuronal networks depends on the interplay between cellular and network synchronization properties . The neuronal phase response curve ( PRC ) is an experimentally obtainable measure that characterizes the cellular response to small perturbations , and can serve as an indicator of ce... | Synchronization of the firing of neurons in the brain is related to many cognitive functions , such as recognizing faces , discriminating odors , and coordinating movement . It is therefore important to understand what properties of neuronal networks promote synchrony of neural firing . One measure that is often used t... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"biology",
"computational",
"biology",
"neuroscience"
] | 2011 | Cellularly-Driven Differences in Network Synchronization Propensity Are Differentially Modulated by Firing Frequency |
Directed cell migration in response to chemical cues , also known as chemotaxis , is an important physiological process involved in wound healing , foraging , and the immune response . Cell migration requires the simultaneous formation of actin polymers at the leading edge and actomyosin complexes at the sides and back... | Neutrophils target sites of infection and inflammation by sensing chemical signals produced by damaged tissue and infecting microbes and then move in the direction where their concentration is greatest . An open question is how neutrophils integrate this information to determine the direction of motility . We present a... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"cell",
"biology",
"homo",
"(human)",
"computational",
"biology"
] | 2007 | A Mathematical Model for Neutrophil Gradient Sensing and Polarization |
In a dynamic world , an accurate model of the environment is vital for survival , and agents ought regularly to seek out new information with which to update their world models . This aspect of behaviour is not captured well by classical theories of decision making , and the cognitive mechanisms of information seeking ... | Acquiring information about the external world is vital for planning and decision making . However , recent research has shown that some animals choose to acquire information at considerable cost even when the information is of no practical benefit , a counter-intuitive behavior associated with suboptimal outcomes . In... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"decision",
"theory",
"medicine",
"and",
"health",
"sciences",
"decision",
"making",
"applied",
"mathematics",
"social",
"sciences",
"neuroscience",
"simulation",
"and",
"modeling",
"systems",
"science",
"mathematics",
"statistics",
"(mathematics)",
"cognition",
"behavior... | 2016 | Intrinsic Valuation of Information in Decision Making under Uncertainty |
Multiscale modeling provides a very powerful means of studying complex biological systems . An important component of this strategy involves coarse-grained ( CG ) simplifications of regions of the system , which allow effective exploration of complex systems . Here we studied aspects of CG modeling of the human zinc tr... | Herein we employed multiscale modeling and electrostatic energy calculations to delineate , for the first time , a putative zinc permeation pathway , from the cytoplasm into intracellular vesicles ( for ZnT2 ) or to the extracellular milieu ( for YiiP ) , along the membrane-spanning domain of the human zinc transporter... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"medicine",
"and",
"health",
"sciences",
"vesicles",
"zinc",
"transporters",
"built",
"structures",
"engineering",
"and",
"technology",
"site-directed",
"mutagenesis",
"simulation",
"and",
"modeling",
"nutrition",
"biological",
"transport",
"molecular",
"biology",
"techni... | 2018 | Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter |
How do humans and other animals face novel problems for which predefined solutions are not available ? Human problem solving links to flexible reasoning and inference rather than to slow trial-and-error learning . It has received considerable attention since the early days of cognitive science , giving rise to well kno... | How humans solve challenging problems such as the Tower of Hanoi ( ToH ) or related puzzles is still largely unknown . Here we advance a computational model that uses the same probabilistic inference methods as those that are increasingly popular in the study of perception and action systems , thus making the point tha... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion",
"Conclusions"
] | [
"learning",
"decision",
"making",
"applied",
"mathematics",
"social",
"sciences",
"problem",
"solving",
"neuroscience",
"learning",
"and",
"memory",
"simulation",
"and",
"modeling",
"algorithms",
"cognitive",
"psychology",
"mathematics",
"probability",
"distribution",
"co... | 2016 | Problem Solving as Probabilistic Inference with Subgoaling: Explaining Human Successes and Pitfalls in the Tower of Hanoi |
Epileptic seizure dynamics span multiple scales in space and time . Understanding seizure mechanisms requires identifying the relations between seizure components within and across these scales , together with the analysis of their dynamical repertoire . Mathematical models have been developed to reproduce seizure dyna... | Neurons communicate via different types of synapses on very fast time scales . The combination of hundred thousand of such interconnected cells within a fluctuating extracellular environment forms a complex network that gives rise to function and behavior via the formation of dynamical patterns of activity . In the con... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [] | 2015 | Computational Modeling of Seizure Dynamics Using Coupled Neuronal Networks: Factors Shaping Epileptiform Activity |
Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock . Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus ( SCN ) , the master circadian pacemaker , CLOCK-deficient mice maintain circadian rhythms in behavior and in tissues in vivo . Ho... | In mammals , circadian clocks are based on a core transcriptional–translational feedback loop . BMAL1 and CLOCK activate the transcription of Per1-3 and Cry1/2 . PER and CRY proteins inhibit BMAL1/CLOCK , and thus their own transcription . In Clock-/- mice , NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"medicine",
"and",
"health",
"sciences",
"vertebrates",
"mice",
"animals",
"electromagnetic",
"radiation",
"fibroblasts",
"circadian",
"oscillators",
"mammals",
"connective",
"tissue",
"cells",
"chronobiology",
"kidneys",
"animal",
"cells",
"connective",
"tissue",
"biolog... | 2016 | NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators |
New efforts are being made to improve understanding of the epidemiology of the helminths and intensifying the control efforts against these parasites . In contrast , relatively few studies are being carried out in this direction for the intestinal protozoa . To contribute to a better comprehension of the epidemiology o... | According to WHO , intestinal amoebiasis caused by Entamoeba histolytica is the third principal parasitic disease responsible for mortality in the world . This protozoal parasite infects approximately 180 million individuals throughout the world , among whom 40 to 110 thousand die from it each year . Giardiasis , cause... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases/protozoal",
"infections",
"infectious",
"diseases/neglected",
"tropical",
"diseases",
"infectious",
"diseases/gastrointestinal",
"infections",
"infectious",
"diseases/epidemiology",
"and",
"control",
"of",
"infectious",
"diseases"
] | 2010 | Prevalence and Spatial Distribution of Entamoeba histolytica/dispar and Giardia lamblia among Schoolchildren in Agboville Area (Côte d'Ivoire) |
Crimean-Congo Haemorrhagic fever Virus ( CCHFV ) is a rapidly emerging vector-borne pathogen and the cause of a virulent haemorrhagic fever affecting large parts of Europe , Africa , the Middle East and Asia . An isothermal recombinase polymerase amplification ( RPA ) assay was successfully developed for molecular dete... | The Crimean-Congo Haemorrhagic fever ( CCHF ) recombinase polymerase amplification assay is a new , rapid and portable diagnostic method . It has been developed for the detection of infection with CCHF virus ( CCHFV ) , the cause of a deadly haemorrhagic disease in humans and an emerging global health threat . As a rap... | [
"Abstract",
"Introduction",
"Materials",
"and",
"methods",
"Results",
"Discussion"
] | [
"reverse",
"transcriptase-polymerase",
"chain",
"reaction",
"medicine",
"and",
"health",
"sciences",
"body",
"fluids",
"crimean-congo",
"hemorrhagic",
"fever",
"tropical",
"diseases",
"rna",
"extraction",
"geographical",
"locations",
"urine",
"neglected",
"tropical",
"dis... | 2017 | A recombinase polymerase amplification assay for rapid detection of Crimean-Congo Haemorrhagic fever Virus infection |
Dengue virus is endemic globally , throughout tropical and sub-tropical regions . While the number of epidemics due to the four DENV serotypes is pronounced in East Africa , the total number of cases reported in Africa ( 16 million infections ) remained at low levels compared to Asia ( 70 million infections ) . The Fre... | Dengue virus is emerging worldwide , however , little is known about the burden of Dengue in Africa . Effectively , only sporadic cases and few epidemics have been reported in the last 30 years . This descriptive study reports clinical and biological data of Dengue-suspected cases analyzed in the Bouffard military hosp... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"blood",
"cells",
"lymphopenia",
"dengue",
"virus",
"medicine",
"and",
"health",
"sciences",
"immune",
"cells",
"body",
"fluids",
"pathology",
"and",
"laboratory",
"medicine",
"pathogens",
"immunology",
"geographical",
"locations",
"microbiology",
"viruses",
"signs",
... | 2016 | Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings |
Rose-comb , a classical monogenic trait of chickens , is characterized by a drastically altered comb morphology compared to the single-combed wild-type . Here we show that Rose-comb is caused by a 7 . 4 Mb inversion on chromosome 7 and that a second Rose-comb allele arose by unequal crossing over between a Rose-comb an... | Comb morphology is a trait that shows considerable variability among domestic chickens . The Rose-comb mutation causes a drastically altered shape of the comb , whereas the Pea-comb mutation leads to a considerable reduction in the size of the comb . The combined effect of Rose-comb and Pea-comb is a comb shaped like a... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"animal",
"genetics",
"functional",
"genomics",
"gene",
"function",
"molecular",
"genetics",
"structural",
"genomics",
"veterinary",
"science",
"veterinary",
"medicine",
"chromosome",
"biology",
"gene",
"expression",
"comparative",
"genomics",
"biology",
"genetics",
"geno... | 2012 | The Rose-comb Mutation in Chickens Constitutes a Structural Rearrangement Causing Both Altered Comb Morphology and Defective Sperm Motility |
The molecular basis for the formation of functional , higher-ordered macro-molecular domains is not completely known . The Kaposi’s Sarcoma-Associated Herpesvirus ( KSHV ) genome forms a super-molecular domain structure during latent infection that is strictly dependent on the DNA binding of the viral nuclear antigen L... | KSHV genomes persist in large nuclear bodies in latently infected cells . The KSHV encoded nuclear antigen LANA is required for the efficient replication and stable maintenance of viral genomes during latent infection . LANA is also known to form oligomeric structures , but it is not known how these structures contribu... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"medicine",
"and",
"health",
"sciences",
"pathology",
"and",
"laboratory",
"medicine",
"cell",
"cycle",
"and",
"cell",
"division",
"pathogens",
"cell",
"processes",
"microbiology",
"dna-binding",
"proteins",
"viral",
"structure",
"viruses",
"viral",
"genome",
"dna",
... | 2019 | LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency |
Over the last decade , implementation research and a science of global health delivery have emerged as important vehicles to improve the effectiveness of interventions . Efforts to control neglected tropical diseases ( NTD ) operate in challenging circumstances and with marginalized populations , making attention to co... | Many efficacious tools exist to control NTDs , but effectively moving these tools and approaches from the boardroom to the village is a complicated socio-political process . In the era of Sustainable Development Goals , global health has become more focused on improving the delivery of existing interventions . Greater ... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"and",
"health",
"sciences",
"tropical",
"diseases",
"geographical",
"locations",
"vertebrates",
"uganda",
"dogs",
"animals",
"mammals",
"rabies",
"tanzania",
"global",
"health",
"neglected",
"tropical",
"diseases",
"africa",
"veterinary",
"science",
"public... | 2018 | Towards a science of global health delivery: A socio-anthropological framework to improve the effectiveness of neglected tropical disease interventions |
Effective triage of dengue patients early in the disease course for in- or out-patient management would be useful for optimal healthcare resource utilization while minimizing poor clinical outcome due to delayed intervention . Yet , early prognosis of severe dengue is hampered by the heterogeneity in clinical presentat... | Dengue , an acute arboviral disease has emerged globally , inflicting debilitating symptoms in 96 million people . The early prediction of severe dengue ( dengue hemorrhagic fever , DHF ) is challenging due to varied and late-presenting symptoms , requiring frequent monitoring for signs of disease progression . An ofte... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"blood",
"cells",
"medicine",
"and",
"health",
"sciences",
"neurochemistry",
"body",
"fluids",
"pathology",
"and",
"laboratory",
"medicine",
"platelet",
"aggregation",
"tropical",
"diseases",
"biomarkers",
"neuroscience",
"serotonin",
"metabolomics",
"metabolites",
"signs... | 2016 | Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever |
Sand fly saliva has an array of pharmacological and immunomodulatory components , and immunity to saliva protects against Leishmania infection . In the present study , we have studied the immune response against Lutzomyia intermedia saliva , the main vector of Leishmania braziliensis in Brazil , and the effects of sali... | Parasites of the genus Leishmania cause a variety of diseases known as leishmaniasis , that are transmitted by bites of female sand flies that , during blood-feeding , inject humans with parasites and saliva . It was shown that , in mice , immunity to sand-fly saliva is able to protect against the development of leishm... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"immunology/immunomodulation",
"infectious",
"diseases/neglected",
"tropical",
"diseases",
"immunology/immune",
"response",
"infectious",
"diseases/protozoal",
"infections",
"immunology/immunity",
"to",
"infections"
] | 2007 | Enhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva |
Helminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides , Trichuris trichiura , and the hookworms Necator americanus and Ancylostoma duodenale as well as other helminths such as Schistosoma mansoni often occur simultaneousl... | Parasitic infections in humans are common in tropical regions and under bad housing and sanitation conditions multiple parasitic infections are the rule rather than the exception . For helminth infections , which are thought to affect almost a quarter of the world's population , most common combinations include soil-tr... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"infectious",
"diseases",
"schistosomiasis",
"soil-transmitted",
"helminths",
"immunity",
"immunity",
"to",
"infections",
"immunology",
"biology",
"neglected",
"tropical",
"diseases",
"hookworm",
"immunomodulation"
] | 2011 | Necator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses |
AKAP200 is a Drosophila melanogaster member of the “A Kinase Associated Protein” family of scaffolding proteins , known for their role in the spatial and temporal regulation of Protein Kinase A ( PKA ) in multiple signaling contexts . Here , we demonstrate an unexpected function of AKAP200 in promoting Notch protein st... | AKAP200 belongs to a family of scaffolding proteins best known for their regulation of PKA localization . In this study , we have identified a novel role of AKAP200 in Notch protein stability and signaling . In Drosophila melanogaster , AKAP200’s loss and gain-of-function ( LOF/GOF ) phenotypes are characteristic of No... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"invertebrates",
"medicine",
"and",
"health",
"sciences",
"lysosomes",
"animals",
"notch",
"signaling",
"animal",
"models",
"drosophila",
"melanogaster",
"model",
"organisms",
"immunoprecipitation",
"experimental",
"organism",
"systems",
"co-immunoprecipitation",
"eyes",
"g... | 2018 | AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster |
In plants , multiple detached tissues are capable of forming a pluripotent cell mass , termed callus , when cultured on media containing appropriate plant hormones . Recent studies demonstrated that callus resembles the root-tip meristem , even if it is derived from aerial organs . This finding improves our understandi... | Callus formation is a necessary step in regenerating a new plant from detached plant tissues , and the nature of the callus is similar to that of the root meristem . In this study , we intended to address the molecular basis that directs different plant tissues to form the root-meristem-like callus . We found that leav... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"developmental",
"biology",
"plant",
"science",
"plant",
"growth",
"and",
"development",
"plant",
"biology",
"genetics",
"epigenetics",
"biology",
"genetics",
"and",
"genomics",
"cell",
"fate",
"determination",
"histone",
"modification"
] | 2012 | Reprogramming of H3K27me3 Is Critical for Acquisition of Pluripotency from Cultured Arabidopsis Tissues |
Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease . Recent studies have additionally found a correlation between psychological stress , telomere length , and health outcome in humans . However , studies have not yet explored the causal relationship between stres... | Over 70 years ago , Barbara McClintock described telomeres and hypothesized about their role in protecting the integrity of chromosomes . Since then , scientists have shown that telomere length is highly regulated and associated with cell senescence and longevity , as well as with age-related disorders and cancer . Her... | [
"Abstract",
"Introduction",
"Results",
"and",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2013 | Environmental Stresses Disrupt Telomere Length Homeostasis |
We report efficacy and safety outcomes from a prospective case series of 31 late-stage T . b . gambiense sleeping sickness ( Human African Trypanosomiasis , HAT ) patients treated with a combination of nifurtimox and eflornithine ( N+E ) in Yumbe , northwest Uganda in 2002–2003 , following on a previously reported term... | African sleeping sickness ( Human African Trypanosomiasis , or HAT ) , due to the parasite Trypanosoma brucei gambiense , threatens millions across remote and conflict-affected regions of sub-Saharan Africa , and causes about 15 000 reported cases every year . Untreated HAT progresses from stage 1 ( infection of the bl... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases/infectious",
"diseases",
"of",
"the",
"nervous",
"system",
"infectious",
"diseases/neglected",
"tropical",
"diseases",
"pharmacology/drug",
"resistance",
"pharmacology/drug",
"development",
"infectious",
"diseases/protozoal",
"infections",
"infectious",
... | 2007 | Nifurtimox plus Eflornithine for Late-Stage Sleeping Sickness in Uganda: A Case Series |
Cardiac aging is a complex process , which is influenced by both environmental and genetic factors . Deciphering the mechanisms involved in heart senescence therefore requires identifying the molecular pathways that are affected by age in controlled environmental and genetic conditions . We describe a functional genomi... | Age-associated changes in cardiac structure and function have been implicated in the markedly increased risk of cardiovascular disease , but the molecular basis of these processes is ill-defined . It is difficult to study the genetics of heart aging in mammalian models because of their long life spans and their complex... | [
"Abstract",
"Introduction",
"Results/Discussion",
"Materials",
"and",
"Methods"
] | [
"functional",
"genomics",
"animal",
"genetics",
"animal",
"models",
"genome",
"analysis",
"tools",
"drosophila",
"melanogaster",
"model",
"organisms",
"gene",
"expression",
"regulatory",
"networks",
"biology",
"transcriptomes",
"microarrays",
"genetics",
"genomics",
"gene... | 2012 | dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila |
Biomedical research has been previously reported to primarily focus on a minority of all known genes . Here , we demonstrate that these differences in attention can be explained , to a large extent , exclusively from a small set of identifiable chemical , physical , and biological properties of genes . Together with kn... | Biomedical research is one of the largest areas of present-day science and embeds the hope and potential to improve the lives of the general public . In order to understand how individual scientists choose individual research questions , we study why certain genes are well studied but others are not . While it has been... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"genome-wide",
"association",
"studies",
"rna",
"interference",
"citation",
"analysis",
"model",
"organisms",
"scientists",
"experimental",
"organism",
"systems",
"genome",
"analysis",
"epigenetics",
"molecular",
"biology",
"techniques",
"science",
"and",
"technology",
"w... | 2018 | Large-scale investigation of the reasons why potentially important genes are ignored |
The p53 tumor suppressor is a sequence-specific pleiotropic transcription factor that coordinates cellular responses to DNA damage and stress , initiating cell-cycle arrest or triggering apoptosis . Although the human p53 binding site sequence ( or response element [RE] ) is well characterized , some genes have consens... | The p53 tumor suppressor is a transcription factor that coordinates cellular responses to DNA damage and stress , initiating cell-cycle arrest or triggering apoptosis . Evolutionary conservation is often employed to separate the functional “wheat” from the nonfunctional “chaff” when identifying binding sites of transcr... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"primates",
"rattus",
"(rat)",
"dog",
"computational",
"biology",
"evolutionary",
"biology",
"homo",
"(human)",
"genetics",
"and",
"genomics",
"mus",
"(mouse)"
] | 2007 | Divergent Evolution of Human p53 Binding Sites: Cell Cycle Versus Apoptosis |
In flat-faced dog breeds , air resistance caused by skull conformation is believed to be a major determinant of Brachycephalic Obstructive Airway Syndrome ( BOAS ) . The clinical presentation of BOAS is heterogeneous , suggesting determinants independent of skull conformation contribute to airway disease . Norwich Terr... | Respiratory diseases are prevalent across dog breeds , particularly in brachycephalic breeds such as the Bulldog and French bulldog . The flat facial conformation of these breeds has long been assumed to be the major predisposing factor , however , the underlying genetics of their respiratory condition has never been e... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"genome-wide",
"association",
"studies",
"animal",
"types",
"medicine",
"and",
"health",
"sciences",
"pathology",
"and",
"laboratory",
"medicine",
"ears",
"vertebrates",
"pets",
"and",
"companion",
"animals",
"dogs",
"animals",
"mammals",
"palate",
"genetic",
"mapping... | 2019 | An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndrome |
Madariaga virus ( MADV ) , also known as South American eastern equine encephalitis virus , has been identified in animals and humans in South and Central America , but not previously in Hispaniola or the northern Caribbean . MADV was isolated from virus cultures of plasma from an 8-year-old child in a school cohort in... | Madariaga virus ( MADV ) is the name given to what used to be called South American eastern equine encephalitis virus ( EEEV ) , based on recent studies suggesting that MADV is distinct genetically from the EEEV circulating in North America . Until now , MADV has been found primarily in animals in South and Central Ame... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"dengue",
"virus",
"children",
"medicine",
"and",
"health",
"sciences",
"body",
"fluids",
"pathology",
"and",
"laboratory",
"medicine",
"education",
"togaviruses",
"eastern",
"equine",
"encephalitis",
"virus",
"pathogens",
"sociology",
"geographical",
"locations",
"micr... | 2019 | Emergence of Madariaga virus as a cause of acute febrile illness in children, Haiti, 2015-2016 |
Transmission of avian influenza viruses from bird to human is a rare event even though avian influenza viruses infect the ciliated epithelium of human airways in vitro and ex vivo . Using an in vitro model of human ciliated airway epithelium ( HAE ) , we demonstrate that while human and avian influenza viruses efficien... | Influenza type A viruses are endemic in aquatic birds but can cross the species barrier to infect the human respiratory tract . While transmission from birds to humans is rare , the introduction of novel avian influenza viruses into immunologically naïve human populations has significant pandemic potential . Avian infl... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"infectious",
"diseases/viral",
"infections",
"virology",
"microbiology",
"infectious",
"diseases/respiratory",
"infections"
] | 2009 | Avian Influenza Virus Glycoproteins Restrict Virus Replication and Spread through Human Airway Epithelium at Temperatures of the Proximal Airways |
Pathogenic species of Leptospira are the causative agents of leptospirosis , a zoonotic disease that causes mortality and morbidity worldwide . The understanding of the virulence mechanisms of Leptospira spp is still at an early stage due to the limited number of genetic tools available for this microorganism . The dev... | Leptospirosis is a neglected infectious disease that sickens many humans and animals throughout the world . It is caused by pathogenic Leptospira spp . Few leptospiral genes that contribute to the disease have been identified . We generated a library of 800 L . interrogans mutants with transposon insertions in differen... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Method",
"Results",
"Discussion"
] | [
"medicine",
"and",
"health",
"sciences",
"leptospira",
"body",
"fluids",
"pathology",
"and",
"laboratory",
"medicine",
"pathogens",
"population",
"genetics",
"microbiology",
"vertebrates",
"animals",
"mammals",
"gene",
"pool",
"genetic",
"elements",
"molecular",
"biolog... | 2016 | High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection |
Previous studies have shown that stimulation of whole blood or peripheral blood mononuclear cells with bacterial virulence factors results in the sequestration of pro-coagulant microvesicles ( MVs ) . These particles explore their clotting activity via the extrinsic and intrinsic pathway of coagulation; however , their... | The coagulation system is much more than a passive bystander in our defense against exogenous microorganisms . Over the last years there has been a growing body of evidence pointing to an integral part of coagulation in innate immunity and a special focus has been on bacterial entrapment in a fibrin network . However ,... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Material",
"and",
"Methods"
] | [
"medicine",
"biology"
] | 2013 | A Novel Role for Pro-Coagulant Microvesicles in the Early Host Defense against Streptococcus pyogenes |
Constraints in embryonic development are thought to bias the direction of evolution by making some changes less likely , and others more likely , depending on their consequences on ontogeny . Here , we characterize the constraints acting on genome evolution in vertebrates . We used gene expression data from two vertebr... | Because embryonic development must proceed correctly for an animal to survive , changes in evolution are constrained according to their effects on development . Changes that disrupt development too dramatically are thus rare in evolution . While this has been long observed at the morphological level , it has been more ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"genetics",
"and",
"genomics/functional",
"genomics",
"developmental",
"biology/developmental",
"evolution",
"evolutionary",
"biology/genomics",
"computational",
"biology/genomics",
"genetics",
"and",
"genomics/bioinformatics",
"evolutionary",
"biology/developmental",
"evolution"
] | 2008 | Developmental Constraints on Vertebrate Genome Evolution |
Increased incidence of hand , foot and mouth disease ( HFMD ) has been recognized as a critical challenge to communicable disease control and public health response . This study aimed to quantify the association between climate variation and notified cases of HFMD in selected cities of Shanxi Province , and to provide ... | Understanding of the impact of weather variables on HFMD transmission remains limited due to various local climatic conditions , socioeconomic status and demographic characteristics in different regions . This study provides quantitative evidence that the incidence of HFMD cases was significantly associated with temper... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [] | 2015 | The Effect of Meteorological Variables on the Transmission of Hand, Foot and Mouth Disease in Four Major Cities of Shanxi Province, China: A Time Series Data Analysis (2009-2013) |
Chromosomal gains and losses comprise an important type of genetic change in tumors , and can now be assayed using microarray hybridization-based experiments . Most current statistical models for DNA copy number estimate total copy number , which do not distinguish between the underlying quantities of the two inherited... | Many genetic diseases are related to copy number aberrations of some regions of the genome . As we know , each chromosome normally has two copies . However , under some circumstances , for some regions , either one or both of the chromosomes change . Genotyping microarray data provides the copy number of the two allele... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"computational",
"biology"
] | 2011 | Estimation of Parent Specific DNA Copy Number in Tumors using High-Density Genotyping Arrays |
Our appreciation for the extent of Epstein Barr virus ( EBV ) transcriptome complexity continues to grow through findings of EBV encoded microRNAs , new long non-coding RNAs as well as the more recent discovery of over a hundred new polyadenylated lytic transcripts . Here we report an additional layer to the EBV transc... | Our understanding of the extent of EBV transcriptome complexity has recently come to light with discoveries of viral microRNAs , snoRNAs , and a diverse set of transcript isoforms expressed during reactivation . While EBV utilizes distinct transcriptional programs during it’s normal infection cycle , the latency progra... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"sequencing",
"techniques",
"medicine",
"and",
"health",
"sciences",
"pathology",
"and",
"laboratory",
"medicine",
"nucleases",
"enzymes",
"pathogens",
"gene",
"regulation",
"dna-binding",
"proteins",
"enzymology",
"microbiology",
"viruses",
"micrornas",
"dna",
"viruses",... | 2018 | The Epstein Barr virus circRNAome |
A purely information theory-guided approach to quantitatively characterize protease specificity is established . We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database . We compare our results with known subpocket specificity profiles for in... | Proteases show a broad range of cleavage specificities . Promiscuous proteases as digestive enzymes unspecifically degrade peptides , whereas highly specific proteases are involved in signaling cascades . As a quantitative index of substrate specificity was lacking , we introduce cleavage entropy as a measure of substr... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"biochemistry",
"protein",
"interactions",
"proteins",
"chemistry",
"biology",
"computational",
"chemistry"
] | 2013 | Cleavage Entropy as Quantitative Measure of Protease Specificity |
Eukaryotic protein kinases ( EPKs ) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain . Our previous computational studies proposed a model stating that a properly assembled nonlinear motif termed the Regulatory ( R ) spine is essential for cataly... | Eukaryotic protein kinases ( EPKs ) have a highly conserved enzymatic kinase core that is involved in the regulation of numerous cell signaling processes through the transfer of a phosphate group from adenosine triphosphate ( ATP ) to more than 30% of human proteins . EPKs have been implicated in numerous human disease... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2013 | Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation |
New foci of human CL caused by strains of the Leishmania donovani ( L . donovani ) complex have been recently described in Cyprus and the Çukurova region in Turkey ( L . infantum ) situated 150 km north of Cyprus . Cypriot strains were typed by Multilocus Enzyme Electrophoresis ( MLEE ) using the Montpellier ( MON ) sy... | In eastern Mediterranean , leishmaniasis represents a major public health problem with considerable impact on morbidity and potential to spread . Cutaneous leishmaniasis ( CL ) caused by L . major or L . tropica accounts for most cases in this region although visceral leishmaniasis ( VL ) caused by L . infantum is also... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"biology"
] | 2012 | Multilocus Microsatellite Typing (MLMT) of Strains from Turkey and Cyprus Reveals a Novel Monophyletic L. donovani Sensu Lato Group |
Chagas disease is a tropical parasitic disease affecting about 10 million people , mostly in the Americas , and transmitted mainly by triatomine bugs . Insect vector control with indoor residual insecticides and the promotion of housing improvement is the main control intervention . The success of such interventions re... | Chagas disease is a tropical parasitic disease affecting about 10 million people , mostly in the Americas , and transmitted mainly by triatomine bugs . The elimination of the insect vectors from houses is the main strategy for the prevention of the disease . The success of such interventions relies on their acceptance ... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases",
"psychology",
"medicine",
"and",
"health",
"sciences",
"chagas",
"disease",
"communication",
"in",
"health",
"care",
"protozoan",
"infections",
"biology",
"and",
"life",
"sciences",
"vector-borne",
"diseases",
"collective",
"human",
"behavior",... | 2014 | Analysis of Children's Perception of Triatomine Vectors of Chagas Disease through Drawings: Opportunities for Targeted Health Education |
Numerous obesity loci have been identified using genome-wide association studies . A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci , but replication studies are lacking . Therefore , we tested whether the aggregate effect of these loci is diminished in adults of Europ... | We undertook analyses in 111 , 421 adults of European descent to examine whether physical activity diminishes the genetic risk of obesity predisposed by 12 single nucleotide polymorphisms , as previously reported in a study of 20 , 000 UK adults ( Li et al , PLoS Med . 2010 ) . Although the study by Li et al is widely ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"genome-wide",
"association",
"studies",
"systems",
"biology",
"medicine",
"nutrition",
"clinical",
"epidemiology",
"clinical",
"research",
"design",
"genetic",
"association",
"studies",
"epidemiology",
"obesity",
"cohort",
"studies",
"genetics",
"population",
"genetics",
... | 2013 | Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry |
Odor-guided behaviors , including homing , predator avoidance , or food and mate searching , are ubiquitous in animals . It is only recently that the neural substrate underlying olfactomotor behaviors in vertebrates was uncovered in lampreys . It consists of a neural pathway extending from the medial part of the olfact... | Olfactory-induced behaviors ( homing , food or mate searching , etc . ) are crucial for the survival and reproduction of most animals . A neural substrate underlying odor-induced behaviors in vertebrates was recently uncovered using a basal vertebrate model: the lamprey . It consists of a neural pathway extending from ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"medicine",
"and",
"health",
"sciences",
"fish",
"brain",
"vertebrates",
"neuroscience",
"animals",
"biological",
"locomotion",
"surgical",
"and",
"invasive",
"medical",
"procedures",
"lampreys",
"olfactory",
"organs",
"functional",
"electrical",
"stimulation",
"animal",
... | 2018 | GABAergic modulation of olfactomotor transmission in lampreys |
If perturbing two genes together has a stronger or weaker effect than expected , they are said to genetically interact . Genetic interactions are important because they help map gene function , and functionally related genes have similar genetic interaction patterns . Mapping quantitative ( positive and negative ) gene... | Genetic interactions indicate functional dependencies between genes and are a powerful tool to predict gene function . Functionally related genes tend to have similar profiles of genetic interactions . Recently , global scale mapping of quantitative ( positive and negative ) genetic interactions has been performed . Th... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"genetics",
"and",
"genomics/genomics",
"genetics",
"and",
"genomics/functional",
"genomics",
"computational",
"biology/molecular",
"genetics",
"genetics",
"and",
"genomics/bioinformatics",
"computational",
"biology/genomics",
"computational",
"biology",
"genetics",
"and",
"gen... | 2011 | Protein Complexes are Central in the Yeast Genetic Landscape |
Both avian and mammalian basal ganglia are involved in voluntary motor control . In birds , such movements include hopping , perching and flying . Two organizational features that distinguish the songbird basal ganglia are that striatal and pallidal neurons are intermingled , and that neurons dedicated to vocal-motor f... | Understanding how gene transcription relates to behavior is challenging . Learned vocal-motor behavior is a complex trait that represents the output of multiple converging genes , pathways , and patterns of neural activity . Here , we applied a systems analytical approach to determine how thousands of genes change thei... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"gene",
"networks",
"neuroscience",
"gene",
"function",
"animal",
"models",
"motor",
"systems",
"model",
"organisms",
"biology",
"neuroethology",
"microarrays",
"systems",
"biology",
"genetics",
"computational",
"biology",
"behavioral",
"neuroscience",
"genetics",
"and",
... | 2012 | Distinct Neurogenomic States in Basal Ganglia Subregions Relate Differently to Singing Behavior in Songbirds |
MicroRNAs ( miRNAs ) are endogenously produced ∼21-nt riboregulators that associate with Argonaute ( Ago ) proteins to direct mRNA cleavage or repress the translation of complementary RNAs . Capturing the molecular mechanisms of miRNA interacting with its target will not only reinforce the understanding of underlying R... | One of the biggest surprises at the beginning of the ‘post-genome era’ was the discovery of numerous genes encoding microRNAs . The number of microRNA genes is estimated to be nearly 1% of that of protein-coding genes , which were found in genomes of such diverse organisms as Caenorhabditis elegans , Drosophila melanog... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"computational",
"biology"
] | 2010 | Mechanism of MicroRNA-Target Interaction: Molecular Dynamics Simulations and Thermodynamics Analysis |
Let-7 miRNAs comprise one of the largest and most highly expressed family of miRNAs among vertebrates , and is critical for promoting differentiation , regulating metabolism , inhibiting cellular proliferation , and repressing carcinogenesis in a variety of tissues . The large size of the Let-7 family of miRNAs has com... | Cancer develops following multiple genetic mutations ( i . e . in tumor suppressors and oncogenes ) , and mutations that cooperate or synergize are often advantageous to cancer cell growth . To study how multiple genes might cooperate , it is usually informative to generate candidate mutations in cells or in mice . Lar... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2015 | Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2 |
Rhodopsin has been used as a prototype system to investigate G protein-coupled receptor ( GPCR ) internalization and endocytic sorting mechanisms . Failure of rhodopsin recycling upon light activation results in various degenerative retinal diseases . Accumulation of internalized rhodopsin in late endosomes and the imp... | Malfunctioning of phototransduction is the major cause of human blindness . Without functional phototransduction , rhodopsin-1 , the major visual pigment , is rapidly endocytosed and accumulated in late endosomes . Impaired lysosomal delivery of endocytosed rhodopsin and its degradation has been reported to trigger pro... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"cell",
"death",
"neurobiology",
"of",
"disease",
"and",
"regeneration",
"cellular",
"stress",
"responses",
"animal",
"genetics",
"genetic",
"mutation",
"neuroscience",
"g-protein",
"signaling",
"gene",
"function",
"animal",
"models",
"drosophila",
"melanogaster",
"mode... | 2013 | Negative Regulation of the Novel norpAP24 Suppressor, diehard4, in the Endo-lysosomal Trafficking Underlies Photoreceptor Cell Degeneration |
Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum . An important role in immune regulation is assigned to the apoptosis-signaling cell surface receptor CD95 ( Fas , APO-1 ) , encoded by the ge... | Severe malaria caused by infection with the protozoan parasite Plasmodium falciparum is a major health burden , causing approximately one million fatalities annually , predominantly among young children in Sub-Saharan Africa . The occurrence of severe malaria may depend on a complex interplay of transmission dynamics a... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"parastic",
"protozoans",
"plasmodium",
"falciparum",
"genetic",
"association",
"studies",
"genetics",
"protozoology",
"biology",
"human",
"genetics",
"microbiology",
"genetics",
"and",
"genomics"
] | 2011 | A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria |
The innate immune response is supposed to play an essential role in the control of amebic liver abscess ( ALA ) , a severe form of invasive amoebiasis due to infection with the protozoan parasite Entamoeba histolytica . In a mouse model for the disease , we previously demonstrated that Jα18-/- mice , lacking invariant ... | Amoebiasis is a widespread human parasitic disease caused by the intestinal protozoan Entamoeba histolytica . There are two major clinical manifestations of the disease , amebic colitis and amebic liver abscess . Interestingly , only a small proportion of E . histolytica-infected individuals develop invasive disease , ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"biochemistry/macromolecular",
"chemistry",
"immunology/innate",
"immunity",
"infectious",
"diseases/protozoal",
"infections",
"infectious",
"diseases/tropical",
"and",
"travel-associated",
"diseases",
"immunology/leukocyte",
"activation"
] | 2009 | Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess |
Nonsense Mediated Decay ( NMD ) degrades transcripts that contain a premature STOP codon resulting from mistranscription or missplicing . However NMD's surveillance of gene expression varies in efficiency both among and within human genes . Previous work has shown that the intron content of human genes is influenced by... | In biological systems mistakes are made constantly because the cellular machinery is complex and error-prone . Mistakes are made in copying DNA for transmission to offspring ( “genetic mutations” ) but are much more frequent in the day-to-day task of gene expression . Genetic mutations are heritable and therefore have ... | [
"Abstract",
"Introduction",
"Results/Discussion",
"Materials",
"and",
"Methods"
] | [
"genetic",
"mutation",
"genome",
"evolution",
"population",
"genetics",
"rna",
"stability",
"dna",
"transcription",
"mutation",
"mutation",
"types",
"molecular",
"genetics",
"sequence",
"analysis",
"gene",
"expression",
"gene",
"splicing",
"biology",
"evolutionary",
"ge... | 2011 | Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes |
Vast research efforts have been devoted to providing clinical diagnostic markers of myocardial infarction ( MI ) , leading to over one million abstracts associated with “MI” and “Cardiovascular Diseases” in PubMed . Accumulation of the research results imposed a challenge to integrate and interpret these results . To a... | Heart attack , known medically as myocardial infarction , often occurs as a result of partial shortage of blood supply to a portion of the heart , leading to the death of heart muscle cells . Following myocardial infarction , complications might arise , including arrhythmia , myocardial rupture , left ventricular dysfu... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"systems",
"biology",
"text",
"mining",
"natural",
"language",
"processing",
"signaling",
"networks",
"biology",
"computational",
"biology"
] | 2014 | Integrative Computational and Experimental Approaches to Establish a Post-Myocardial Infarction Knowledge Map |
In neurons , the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones , recruitment of regulatory proteins to chromatin and changes to nuclear structure . To identify genes and regulatory elements responsive to synaptic activation ... | In neurons , acetylation of histones and other epigenetic modifications influence gene expression in response to synaptic activity . Genes that are concomitantly expressed in response to stimulation are transcribed at specific nuclear foci , known as transcription factories ( TFs ) that are enriched with active RNA Pol... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"cellular",
"structures",
"chromosome",
"structure",
"and",
"function",
"neuroscience",
"cell",
"differentiation",
"dna",
"transcription",
"histone",
"modification",
"animal",
"models",
"developmental",
"biology",
"model",
"organisms",
"epigenetics",
"cell",
"nucleus",
"c... | 2013 | Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories |
Type 1 interferons ( T1-IFNs ) play a major role in antiviral defense , but when or how they protect during infections that spread through the lympho-hematogenous route is not known . Orthopoxviruses , including those that produce smallpox and mousepox , spread lympho-hematogenously . They also encode a decoy receptor ... | Type 1 interferons are molecules important in the defense against viruses . Orthopoxviruses encode a Type 1 interferon binding protein that acts as a decoy for the Type 1 interferon receptor . Here we show that during infection with the Orthopoxvirus ectromelia virus , the agent of mousepox , Type 1 interferons protect... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"immunity",
"to",
"infections",
"immunology",
"microbiology",
"host-pathogen",
"interaction",
"mechanisms",
"of",
"resistance",
"and",
"susceptibility",
"immunotherapy",
"animal",
"models",
"of",
"infection",
"virulence",
"factors",
"and",
"mechanisms",
"viral",
"immune",... | 2012 | Antibody Inhibition of a Viral Type 1 Interferon Decoy Receptor Cures a Viral Disease by Restoring Interferon Signaling in the Liver |
Two distinct Polycomb complexes , PRC1 and PRC2 , collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells ( ESCs ) . PRC1 and PRC2 have histone modifying activities , catalyzing mono-ubiquitination of histone H2A ( H2AK119u1 ) and trimethylation of H3 lysine 27 ( H3K27me3 ) , res... | Polycomb-group ( PcG ) proteins play essential roles in the epigenetic regulation of gene expression during development . PcG proteins form two distinct multimeric complexes , PRC1 and PRC2 . In the widely accepted hierarchical model , PRC2 is recruited to specific genomic locations and catalyzes trimethylation of H3 l... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"genome-wide",
"association",
"studies",
"gene",
"regulation",
"cell",
"differentiation",
"histone",
"modification",
"developmental",
"biology",
"genome",
"analysis",
"tools",
"stem",
"cells",
"epigenetics",
"molecular",
"genetics",
"chromatin",
"chromosome",
"biology",
"... | 2012 | Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity |
Leishmania is a protozoan parasite that alternates its life cycle between the sand-fly vector and the mammalian host . This alternation involves environmental changes and leads the parasite to dynamic modifications in morphology , metabolism , cellular signaling and regulation of gene expression to allow for a rapid ad... | Leishmania are auxotrophic for many essential nutrients , including amino acids . In this way , the parasite needs to uptake the amino acids from the environment . The uptake of amino acids is mediated by amino acid transporters that are unique for Leishmania . As part of polyamine pathway , the arginase converts L-arg... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion",
"Conclusions"
] | [
"medicine",
"and",
"health",
"sciences",
"chemical",
"compounds",
"gene",
"regulation",
"microbiology",
"parasitic",
"diseases",
"parasitic",
"protozoans",
"protozoan",
"life",
"cycles",
"parasitology",
"organic",
"compounds",
"developmental",
"biology",
"protozoans",
"le... | 2017 | RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginase-dependent gene expression regulation |
Cryptococcus gattii causes life-threatening disease in otherwise healthy hosts and to a lesser extent in immunocompromised hosts . The highest incidence for this disease is on Vancouver Island , Canada , where an outbreak is expanding into neighboring regions including mainland British Columbia and the United States . ... | Emerging and reemerging infectious diseases are increasing worldwide and represent a major public health concern . One class of emerging human and animal diseases is caused by fungi . In this study , we examine the expansion on an outbreak of a fungus , Cryptococcus gattii , in the Pacific Northwest of the United State... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases/fungal",
"infections",
"molecular",
"biology",
"genetics",
"and",
"genomics",
"microbiology"
] | 2010 | Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States |
Humans and animals are able to learn complex behaviors based on a massive stream of sensory information from different modalities . Early animal studies have identified learning mechanisms that are based on reward and punishment such that animals tend to avoid actions that lead to punishment whereas rewarded actions ar... | Humans and animals are able to learn complex behaviors based on a massive stream of sensory information from different modalities . Early animal studies have identified learning mechanisms that are based on reward and punishment such that animals tend to avoid actions that lead to punishment whereas rewarded actions ar... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"neuroscience/behavioral",
"neuroscience",
"neuroscience/natural",
"and",
"synthetic",
"vision",
"neuroscience/theoretical",
"neuroscience",
"computational",
"biology/computational",
"neuroscience"
] | 2010 | Reinforcement Learning on Slow Features of High-Dimensional Input Streams |
Gene-expression deconvolution is used to quantify different types of cells in a mixed population . It provides a highly promising solution to rapidly characterize the tumor-infiltrating immune landscape and identify cold cancers . However , a major challenge is that gene-expression data are frequently contaminated by m... | Rapidly emerging evidence suggests that the tumor immune microenvironment not only predisposes cancer patients to diverse treatment outcomes but also represents a promising source of biomarkers for better patient stratification . Different from the immunohistochemistry-based scoring practice , which focuses on a few se... | [
"Abstract",
"Introduction",
"Materials",
"and",
"methods",
"Results",
"Discussion"
] | [
"blood",
"cells",
"medicine",
"and",
"health",
"sciences",
"immune",
"cells",
"engineering",
"and",
"technology",
"applied",
"mathematics",
"immunology",
"pert",
"simulation",
"and",
"modeling",
"algorithms",
"probability",
"distribution",
"mathematics",
"lymph",
"nodes... | 2019 | Fast and robust deconvolution of tumor infiltrating lymphocyte from expression profiles using least trimmed squares |
Genomic imprinting is a process that causes genes to be expressed from one allele only according to parental origin , the other allele being silent . Diseases can arise when the normally active alleles are not expressed . In this context , low level of expression of the normally silent alleles has been considered as ge... | Genomic imprinting is a process that causes genes to be expressed from only one of the two chromosomes , according to parental origin , the other copy of genes being silent . Prader-Willi Syndrome ( PWS ) is a neurodevelopmental disease involving imprinted genes , including NDN , which are only expressed from the pater... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2013 | Stochastic Loss of Silencing of the Imprinted Ndn/NDN Allele, in a Mouse Model and Humans with Prader-Willi Syndrome, Has Functional Consequences |
Ebola virus ( EBOV ) is a highly pathogenic filovirus that causes hemorrhagic fever in humans and animals . Currently , how EBOV fuses its envelope membrane within an endosomal membrane to cause infection is poorly understood . We successfully measure cell-cell fusion mediated by the EBOV fusion protein , GP , assayed ... | The devastation and transmissibility of Ebola virus ( EBOV ) are well known . However , the manner in which EBOV enters host cells through endosomal membrane remains elusive . Here , we have developed a convenient experimental system to mimic EBOV fusion in endosomes: cells expressing the fusion protein of EBOV , GP , ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2016 | Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger |
Gliomas , the most common malignant tumors of the nervous system , frequently harbor mutations that activate the epidermal growth factor receptor ( EGFR ) and phosphatidylinositol-3 kinase ( PI3K ) signaling pathways . To investigate the genetic basis of this disease , we developed a glioma model in Drosophila . We fou... | Malignant gliomas , tumors composed of glial cells and their precursors , are the most common and deadly human brain tumors . These tumors infiltrate the brain and proliferate rapidly , properties that render them largely incurable even with current therapies . Mutations in genes within the EGFR-Ras and PI3K signaling ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"cell",
"biology/neuronal",
"and",
"glial",
"cell",
"biology",
"cell",
"biology/cell",
"signaling",
"oncology/neuro-oncology",
"cell",
"biology/cell",
"growth",
"and",
"division",
"genetics",
"and",
"genomics/disease",
"models",
"neuroscience/neurodevelopment",
"developmental... | 2009 | A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma |
Microtubule-based kinesin motors have many cellular functions , including the transport of a variety of cargos . However , unconventional roles have recently emerged , and kinesins have also been reported to act as scaffolding proteins and signaling molecules . In this work , we further extend the notion of unconventio... | Myelin is a multilayered extension of the Schwann and oligodendrocyte cell membranes , which wraps around neuronal axons to facilitate propagation of electric signals and to support axonal metabolism . However , the signals regulating myelin formation and how they are integrated and controlled to achieve homeostasis ar... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Material",
"and",
"Methods"
] | [
"phosphorylation",
"medicine",
"and",
"health",
"sciences",
"nervous",
"system",
"neuroscience",
"macroglial",
"cells",
"optic",
"nerve",
"schwann",
"cells",
"nerve",
"fibers",
"spinal",
"cord",
"animal",
"cells",
"proteins",
"glial",
"cells",
"biochemistry",
"cellula... | 2016 | Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold |
Alveolar echinococcosis , caused by Echinococcus multilocularis larvae , is a chronic disease associated with considerable modulation of the host immune response . Dendritic cells ( DC ) are key effectors in shaping the immune response and among the first cells encountered by the parasite during an infection . Although... | Parasitic helminths are inducers of chronic diseases and have evolved mechanisms to suppress the host immune response . Mostly from studies on roundworms , a picture is currently emerging that helminths secrete factors ( E/S-products ) that directly act on sentinels of the immune system , dendritic cells , in order to ... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"immune",
"cells",
"clinical",
"immunology",
"immunity",
"immunology",
"biology",
"microbiology",
"zoology"
] | 2012 | Excretory/Secretory-Products of Echinococcus multilocularis Larvae Induce Apoptosis and Tolerogenic Properties in Dendritic Cells In Vitro |
Two highly similar RNA polymerase sigma subunits , σF and σG , govern the early and late phases of forespore-specific gene expression during spore differentiation in Bacillus subtilis . σF drives synthesis of σG but the latter only becomes active once engulfment of the forespore by the mother cell is completed , its le... | Positive auto-regulation of a transcriptional activator during cell differentiation or development often allows the rapid and robust deployment of cell- and stage-specific genes and the routing of the differentiating cell down a specific path . Positive auto-regulation however , raises the potential for inappropriate a... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"developmental",
"biology",
"cell",
"fate",
"determination",
"genetic",
"screens",
"gene",
"expression",
"genetics",
"biology",
"microbial",
"growth",
"and",
"development",
"microbiology",
"genetics",
"and",
"genomics",
"cell",
"differentiation",
"dna",
"transcription",
... | 2011 | A Negative Feedback Loop That Limits the Ectopic Activation of a Cell Type–Specific Sporulation Sigma Factor of Bacillus subtilis |
Restrictions on nematicide usage underscore the need for novel control strategies for plant pathogenic nematodes such as Globodera pallida ( potato cyst nematode ) that impose a significant economic burden on plant cultivation activities . The nematode neuropeptide signalling system is an attractive resource for novel ... | Plant pathogenic nematodes compromise plant health and productivity globally and are an increasing problem due to the lack of efficient control measures . The nematode nervous system depends heavily on small proteins ( neuropeptides ) for communication between nerve cells and other nerve cells or other cell types . The... | [
"Abstract",
"Introduction",
"Results/Discussion",
"Materials",
"and",
"Methods"
] | [
"molecular",
"neuroscience",
"rna",
"interference",
"small",
"molecules",
"neuroscience",
"gene",
"function",
"immunochemistry",
"molecular",
"genetics",
"signaling",
"pathways",
"gene",
"expression",
"biology",
"molecular",
"biology",
"drug",
"discovery",
"biochemistry",
... | 2013 | flp-32 Ligand/Receptor Silencing Phenocopy Faster Plant Pathogenic Nematodes |
Human African trypanosomiasis ( HAT ) , or sleeping sickness , results from infection with the protozoan parasites Trypanosoma brucei ( T . b . ) gambiense or T . b . rhodesiense and is invariably fatal if untreated . There are 60 million people at risk from the disease throughout sub-Saharan Africa . The infection pro... | Human African trypanosomiasis ( HAT ) is caused by infection with either Trypanosoma brucei gambiense or T . b . rhodesiense and is fatal if untreated . In the late stages of the disease the parasites enter the brain , producing severe neurological symptoms . The arsenical drug melarsoprol is the only treatment availab... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"infectious",
"diseases",
"infectious",
"diseases",
"of",
"the",
"nervous",
"system",
"drugs",
"and",
"devices",
"african",
"trypanosomiasis",
"parasitic",
"diseases"
] | 2011 | Melarsoprol Cyclodextrin Inclusion Complexes as Promising Oral Candidates for the Treatment of Human African Trypanosomiasis |
We report the first genome-wide association study of habitual caffeine intake . We included 47 , 341 individuals of European descent based on five population-based studies within the United States . In a meta-analysis adjusted for age , sex , smoking , and eigenvectors of population variation , two loci achieved genome... | Caffeine is the most widely consumed psychoactive substance in the world . Although demographic and social factors have been linked to habitual caffeine consumption , twin studies report a large heritable component . Through a comprehensive search of the human genome involving over 40 , 000 participants , we discovered... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Material",
"and",
"Methods"
] | [
"social",
"and",
"behavioral",
"sciences"
] | 2011 | Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
Here we put forward a mathematical model describing the response of low-grade ( WHO grade II ) oligodendrogliomas ( LGO ) to temozolomide ( TMZ ) . The model describes the longitudinal volumetric dynamics of tumor response to TMZ of a cohort of 11 LGO patients treated with TMZ . After finding patient-specific parameter... | We developed a mathematical model describing the longitudinal volumetric growth data of grade II oligodendroglioma patients and their response to temozolomide . The model was used to explore alternative therapeutic protocols for the in-silico twins of the patients and in virtual clinical trials . The simulations show t... | [
"Abstract",
"Introduction",
"Materials",
"and",
"methods",
"Results",
"Discussion"
] | [
"cell",
"death",
"medicine",
"and",
"health",
"sciences",
"pathology",
"and",
"laboratory",
"medicine",
"cancer",
"treatment",
"clinical",
"oncology",
"cell",
"processes",
"cancers",
"and",
"neoplasms",
"mathematical",
"models",
"toxicology",
"oncology",
"neurological",... | 2019 | Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas |
Eukaryotic gene expression involves tight coordination between transcription and pre–mRNA splicing; however , factors responsible for this coordination remain incompletely defined . Here , we explored the genetic , functional , and biochemical interactions of a likely coordinator , Npl3 , an SR-like protein in Saccharo... | Pre-messenger RNA splicing is the process by which an intron is identified and removed from a transcript and the protein-coding exons are ligated together . It is carried out by the spliceosome , a large and dynamic molecular machine that catalyzes the splicing reaction . It is now apparent that most splicing occurs wh... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"genetics",
"biology",
"molecular",
"cell",
"biology",
"genetics",
"and",
"genomics"
] | 2012 | The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing |
Glutamate-gated chloride channel receptors ( GluClRs ) mediate inhibitory neurotransmission at invertebrate synapses and are primary targets of parasites that impact drastically on agriculture and human health . Ivermectin ( IVM ) is a broad-spectrum pesticide that binds and potentiates GluClR activity . Resistance to ... | Glutamate-gated chloride channel receptors ( GluClRs ) mediate chemoelectric inhibition in invertebrate animals and are targets for broad-spectrum pesticides such as ivermectin . However , resistance to ivermectin threatens the effective control of invertebrates that cause a range of agricultural and human diseases . T... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"methods"
] | [
"invertebrates",
"single",
"channel",
"recording",
"neurochemistry",
"caenorhabditis",
"vertebrates",
"social",
"sciences",
"neuroscience",
"animals",
"xenopus",
"germ",
"cells",
"animal",
"models",
"oocytes",
"caenorhabditis",
"elegans",
"model",
"organisms",
"amphibians",... | 2019 | GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance |
Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology . The multifaceted physiological role of the metabolic network fulfilling the catalytic conversions can only be fully understood from a whole-body perspective w... | Cellular metabolism is a key element in human physiology . Ideally the metabolic network needs to be considered within the context of the surrounding tissue and organism since the various levels of biological organization are mutually influencing each other . To mechanistically describe the interplay between intracellu... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"medicine",
"drug",
"absorption",
"drugs",
"and",
"devices",
"metabolic",
"networks",
"population",
"modeling",
"pharmacology",
"drug",
"metabolism",
"drug",
"distribution",
"biology",
"metabolic",
"disorders",
"pharmacokinetics",
"systems",
"biology",
"computational",
"b... | 2012 | Integrating Cellular Metabolism into a Multiscale Whole-Body Model |
Human kidney function declines with age , accompanied by stereotyped changes in gene expression and histopathology , but the mechanisms underlying these changes are largely unknown . To identify potential regulators of kidney aging , we compared age-associated transcriptional changes in the human kidney with genome-wid... | The structure and function of human kidneys deteriorate steadily with age , yet little is known about the underlying causes of kidney aging . In this work , we first used a genomics approach to identify candidate regulators of gene expression changes in the aging human kidney and identified inflammation-related transcr... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2015 | The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney |
Campylobacter jejuni is one of the major causes of infectious diarrhea world-wide , although relatively little is know about its mechanisms of pathogenicity . This bacterium can gain entry into intestinal epithelial cells , which is thought to be important for its ability to persistently infect and cause disease . We f... | Campylobacter jejuni is one of the most common causes of food-borne illness in the United States and a major cause of diarrheal disease throughout the world . After infection through the oral route , this bacterium invades the cells of the intestinal epithelium , a property that is important for its ability to cause di... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"cell",
"biology",
"infectious",
"diseases",
"microbiology",
"eubacteria"
] | 2008 | Campylobacter jejuni Survives within Epithelial Cells by Avoiding Delivery to Lysosomes |
Rainfall patterns are one of the main drivers of dengue transmission as mosquitoes require standing water to reproduce . However , excess rainfall can be disruptive to the Aedes reproductive cycle by “flushing out” aquatic stages from breeding sites . We developed models to predict the occurrence of such “flushing” eve... | Dengue transmission is sensitive to fluctuations in rainfall and other weather conditions because it is transmitted by the Aedes mosquito . Recent studies have identified that extreme rainfall can result in mosquito breeding site flushing . However , these rainfall conditions have neither been described nor evaluated f... | [
"Abstract",
"Introduction",
"Materials",
"and",
"methods",
"Results",
"Discussion"
] | [
"invertebrates",
"medicine",
"and",
"health",
"sciences",
"monsoons",
"atmospheric",
"science",
"geographical",
"locations",
"animals",
"singapore",
"seasons",
"developmental",
"biology",
"storms",
"insect",
"vectors",
"zoology",
"infectious",
"diseases",
"life",
"cycles"... | 2018 | Statistical modeling of the effect of rainfall flushing on dengue transmission in Singapore |
Disruption of certain genes can reveal cryptic genetic variants that do not typically show phenotypic effects . Because this phenomenon , which is referred to as ‘phenotypic capacitance’ , is a potential source of trait variation and disease risk , it is important to understand how it arises at the genetic and molecula... | Some genetic polymorphisms have phenotypic effects that are masked under most conditions , but can be revealed by mutations or environmental change . The genetic and molecular mechanisms that suppress and uncover these cryptic genetic variants are important to understand . Here , we show that a single mutation in a yea... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [] | 2015 | Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions |
Human African trypanosomiasis ( HAT ) , also known as sleeping sickness , is a parasitic tropical disease . It progresses from the first , haemolymphatic stage to a neurological second stage due to invasion of parasites into the central nervous system ( CNS ) . As treatment depends on the stage of disease , there is a ... | The actual serological and parasitological tests used for the diagnosis of human African trypanosomiasis ( HAT ) , also known as sleeping sickness , are not sensitive and specific enough . The card agglutination test for trypanosomiasis ( CATT ) assay , widely used for the diagnosis , is restricted to the gambiense for... | [
"Abstract",
"Introduction",
"Material",
"and",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases/neglected",
"tropical",
"diseases",
"biochemistry/bioinformatics"
] | 2009 | A Combined CXCL10, CXCL8 and H-FABP Panel for the Staging of Human African Trypanosomiasis Patients |
Leprosy is an insidious infectious disease caused by the obligate intracellular bacteria Mycobacterium leprae , and host genetic factors can modulate the immune response and generate distinct categories of leprosy susceptibility that are also influenced by genetic ancestry . We investigated the possible effects of CYP1... | Leprosy is an infectious disease caused by Mycobacterium leprae , which can carry to skin lesions and affect peripheral nerves , which cause physical and motor injuries on the patients . Moreover , leprosy , may be classified in two major groups , based on clinical manifestations in Paucibacillary ( PB ) or Multibacill... | [
"Abstract",
"Introduction",
"Materials",
"and",
"Methods",
"Results",
"Discussion"
] | [] | 2015 | Influence of Genetic Ancestry on INDEL Markers of NFKβ1, CASP8, PAR1, IL4 and CYP19A1 Genes in Leprosy Patients |
We address the problem of homology identification in complex multidomain families with varied domain architectures . The challenge is to distinguish sequence pairs that share common ancestry from pairs that share an inserted domain but are otherwise unrelated . This distinction is essential for accuracy in gene annotat... | New genes evolve through the duplication and modification of existing genes . As a result , genes that share common ancestry tend to have similar structure and function . Computational methods that use common ancestry have been extraordinarily successful in inferring function . The practice of discerning evolutionary r... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Methods"
] | [
"evolutionary",
"biology/evolutionary",
"and",
"comparative",
"genetics",
"computational",
"biology/comparative",
"sequence",
"analysis",
"computational",
"biology/protein",
"homology",
"detection",
"computational",
"biology/evolutionary",
"modeling",
"evolutionary",
"biology/genom... | 2008 | Sequence Similarity Network Reveals Common Ancestry of Multidomain Proteins |
Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes . To study the mechanisms controlling the degradation of apoptotic cells , we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events ... | Cells undergoing programmed cell death , or apoptosis , within an animal are swiftly engulfed by phagocytes and degraded inside phagosomes , vesicles in which the apoptotic cell is bounded by the engulfing cell's membrane . Little is known about how the degradation process is triggered and controlled . We studied the d... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods",
"Supporting",
"Information"
] | [
"developmental",
"biology",
"cell",
"biology",
"genetics",
"and",
"genomics"
] | 2008 | Phagocytic Receptor CED-1 Initiates a Signaling Pathway for Degrading Engulfed Apoptotic Cells |
The progression and variation of pathology during infections can be due to components from both host or pathogen , and/or the interaction between them . The influence of host genetic variation on disease pathology during infections with trypanosomes has been well studied in recent years , but the role of parasite genet... | Trypanosomes are single-celled organisms that are transmitted between animal hosts by the tsetse fly . These parasites infect a wide range of mammals and in sub-Saharan Africa are extensively debilitating to livestock , and some species are also able to infect humans causing a disease , sleeping sickness , that is usua... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"infectious",
"diseases/protozoal",
"infections",
"infectious",
"diseases/neglected",
"tropical",
"diseases",
"genetics",
"and",
"genomics/complex",
"traits"
] | 2009 | A Major Genetic Locus in Trypanosoma brucei Is a Determinant of Host Pathology |
In spite of its evolutionary significance and conservation importance , the population structure of the common chimpanzee , Pan troglodytes , is still poorly understood . An issue of particular controversy is whether the proposed fourth subspecies of chimpanzee , Pan troglodytes ellioti , from parts of Nigeria and Came... | Chimpanzees are viewed with fondness as our closest animal relatives and are valued by scientists for the biological and evolutionary insights they provide . In spite of this , the relationships between different populations of common chimpanzees are still relatively poorly understood , a situation that potentially thr... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"ecology",
"genetics",
"population",
"genetics",
"biology",
"genomics",
"population",
"biology",
"genetics",
"and",
"genomics"
] | 2012 | Genomic Tools for Evolution and Conservation in the Chimpanzee: Pan troglodytes ellioti Is a Genetically Distinct Population |
Few live attenuated vaccines protect against multiple serotypes of bacterial pathogen because host serotype-specific immune responses are limited to the serotype present in the vaccine strain . Here , immunization with a mutant of Shigella flexneri 2a protected guinea pigs against subsequent infection by S . dysenteria... | An ideal vaccine should show a broad range of protective efficacy against all serotypes of a particular pathogen . Variations in the structural lipopolysaccharide “O”-antigen mean that it is difficult to induce protection against multiple serotype Shigella strains using a single serotype immunogen . Here , we examined ... | [
"Abstract",
"Introduction",
"Materials",
"and",
"methods",
"Results",
"Discussion"
] | [
"medicine",
"and",
"health",
"sciences",
"immune",
"physiology",
"pathology",
"and",
"laboratory",
"medicine",
"pathogens",
"immunology",
"tropical",
"diseases",
"microbiology",
"vertebrates",
"animals",
"mammals",
"shigella",
"animal",
"models",
"vaccines",
"bacterial",
... | 2017 | An attenuated Shigella mutant lacking the RNA-binding protein Hfq provides cross-protection against Shigella strains of broad serotype |
Canine leishmaniasis ( CanL ) is a zoonotic disease , caused by Leishmania infantum and transmitted by Phlebotomus perniciosus in the Mediterranean basin . Previously , an ELISA based on the P . perniciosus salivary protein SP03B was proposed as a valid tool to screen for canine exposure to sand fly bites across region... | The sand fly Phlebotomus perniciosus is the principle vector of Leishmania infantum , causing canine leishmaniasis in the Mediterranean basin . While the sand fly female takes a blood meal , it injects saliva into the host skin , evoking a specific antibody response in the host . The antibody level in the host correlat... | [
"Abstract",
"Introduction",
"Methods",
"Results",
"Discussion"
] | [
"medicine",
"and",
"health",
"sciences",
"enzyme-linked",
"immunoassays",
"body",
"fluids",
"pathology",
"and",
"laboratory",
"medicine",
"vertebrates",
"sand",
"flies",
"saliva",
"dogs",
"animals",
"mammals",
"infectious",
"disease",
"control",
"insect",
"vectors",
"... | 2018 | Evaluation of the rSP03B sero-strip, a newly proposed rapid test for canine exposure to Phlebotomus perniciosus, vector of Leishmania infantum |
Trypanosomatid parasites cause serious infections in humans and production losses in livestock . Due to the high divergence from other eukaryotes , such as humans and model organisms , the functional roles of many trypanosomatid proteins cannot be predicted by homology-based methods , rendering a significant portion of... | Methods to predict protein function based on sequences enable the rapid annotation of newly sequenced genomes . However , as most of these methods rely on homology-based approaches , non-conserved proteins in trypanosomatids remain elusive for annotation , rendering approximately half of the sequenced proteins uncharac... | [
"Abstract",
"Introduction",
"Program",
"description",
"and",
"methods",
"Conclusions",
"and",
"future",
"directions"
] | [
"protein",
"interactions",
"protein",
"interaction",
"networks",
"parasitic",
"protozoans",
"organisms",
"genomic",
"databases",
"trypanosoma",
"brucei",
"gambiense",
"protozoans",
"network",
"analysis",
"genome",
"analysis",
"sequence",
"motif",
"analysis",
"research",
"... | 2017 | TrypsNetDB: An integrated framework for the functional characterization of trypanosomatid proteins |
Cis-regulatory sequences are not always conserved across species . Divergence within cis-regulatory sequences may result from the evolution of species-specific patterns of gene expression or the flexible nature of the cis-regulatory code . The identification of functional divergence in cis-regulatory sequences is there... | Research in the field of molecular evolution is focused on understanding the genetic basis of functional differences between species . Protein coding sequences have traditionally been the focus of these studies , as the genetic code enables a detailed study of the strength of selection acting on amino acid sequences . ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Materials",
"and",
"Methods"
] | [
"yeast",
"and",
"fungi",
"eukaryotes",
"computational",
"biology",
"evolutionary",
"biology",
"genetics",
"and",
"genomics",
"saccharomyces"
] | 2007 | Frequent Gain and Loss of Functional Transcription Factor Binding Sites |
Influenza viruses have been responsible for large losses of lives around the world and continue to present a great public health challenge . Antigenic characterization based on hemagglutination inhibition ( HI ) assay is one of the routine procedures for influenza vaccine strain selection . However , HI assay is only a... | Influenza antigenic cartography is an analogy of geographic cartography , and it projects influenza antigens into a two- or three-dimensional map through which we can visualize and measure the antigenic distances between influenza antigens as we visualize and measure geographic distances between the cities in a geograp... | [
"Abstract",
"Introduction",
"Results",
"Discussions"
] | [
"computer",
"science",
"immunology/immune",
"response",
"virology",
"evolutionary",
"biology/bioinformatics",
"computational",
"biology",
"mathematics/statistics"
] | 2010 | A Computational Framework for Influenza Antigenic Cartography |
A previous genome-wide association ( GWA ) meta-analysis of 12 , 386 PD cases and 21 , 026 controls conducted by the International Parkinson's Disease Genomics Consortium ( IPDGC ) discovered or confirmed 11 Parkinson's disease ( PD ) loci . This first analysis of the two-stage IPDGC study focused on the set of loci th... | This paper describes the largest case-control analysis of Parkinson's disease to date , with a combined sample set of over 12 , 000 cases and 21 , 000 controls . After combining our findings with an independent replication dataset of more than 3 , 000 cases and 29 , 000 controls , we found five additional PD risk loci ... | [
"Abstract",
"Introduction",
"Results",
"Discussion",
"Material",
"and",
"Methods"
] | [
"genome-wide",
"association",
"studies",
"genetics",
"biology",
"genetics",
"of",
"disease",
"neuroscience",
"genetics",
"and",
"genomics"
] | 2011 | A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.