text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we have therefore studied the binding of five mitogenic plant lectins , namely pha , pwm , cona , mpa and psa to three major human lymphocyte subsets as defined by anti-cd4 , anti-cd8 and anti-cd16 monoclonal antibodies . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
56,
69
]
} | {
"id": "C0009630",
"name": "cona",
"pos": [
91,
95
]
} |
the mab h466 was used as a capture antibody and bound c3a-desarg was detected with a second peroxidase-labelled anti-c3a mab . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
35,
43
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
121,
124
]
} |
a number of different mouse strains and immunization protocols were used to attempt to make monoclonal antibodies against rat ige for use in studies of the structure , biological activities and regulation of this class of antibody . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
103,
113
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
213,
218
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting ( western blotting ) were evaluated and found to be useful in determining the antigen and antibody components of these immune complexes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
167,
175
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
196,
212
]
} |
virus antigen of hemorrhagic fever with renal syndrome in peripheral blood mononuclear cells ( pbmcs ) was usually present before day 11 of the disease , especially from days 4-7 . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
46,
54
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
144,
151
]
} |
pbmcs were especially useful in isolating viruses from patients with hemorrhagic fever with renal syndrome in whom antibody titers were generally high during the acute phase of the disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
98,
106
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
181,
188
]
} |
to determine if beta-lactamase produced by hemophilus influenzae and branhamella catarrhalis have similar importance in mixed infections , a thread infection model in mice was used to evaluate the capacity of beta-lactamase produced by s. aureus , b. catarrhalis , or h. influenzae to hydrolyze ampicillin in a mixed infection with streptococcus pneumoniae in mice . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
126,
135
]
} | {
"id": "C0275524",
"name": "mixed infection",
"pos": [
311,
326
]
} |
once-daily therapy with ceftriaxone compared with daily multiple-dose therapy with cefotaxime for serious bacterial infections : a randomized , double-blind study . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
24,
35
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
83,
93
]
} |
a randomized , double-blind study was done to compare the efficacy and toxicity of daily single-dose therapy with intravenous ceftriaxone ( 2 g every 24 h ) with daily multiple-dose therapy with cefotaxime ( 2 g every 6 h ) for treatment of serious bacterial infections in nonneutropenic patients . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
126,
137
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
195,
205
]
} |
thus , daily single-dose therapy with ceftriaxone was comparable to daily multiple-dose therapy with cefotaxime in treating these bacterial infections . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
38,
49
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
101,
111
]
} |
ceftriaxone was compared with cefotaxime for the treatment of serious bacterial infections in a prospective , randomized , double-blind clinical trial . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
0,
11
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
30,
40
]
} |
ceftriaxone 2 g once a day was as safe and effective as cefotaxime 2 g every 4 h for suspected serious bacterial infections . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
0,
11
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
56,
66
]
} |
in this aids commentary he discusses the critical clinical questions relevant to syphilis in persons with hiv infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
8,
12
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
106,
119
]
} |
methylprednisolone did not appear to alter pancreatic vo2 , which showed a significant increasing trend from + 77 % 1 h after mpss had been given , to + 98 % 3 h later ( vs + 56 and + 92 % , respectively , in the control group ) . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
0,
18
]
} | {
"id": "C0700546",
"name": "mpss",
"pos": [
126,
130
]
} |
treatment of mice with endotoxin ( lipopolysaccharide , lps ) and the two lps-induced monokines , tumor necrosis factor ( tnf ) and interleukin-1 ( il-1 ) , caused a depression of liver cytochrome p-450 and related drug-metabolizing enzymes , as well as other acute-phase changes including increase in plasma fibrinogen levels and hypoferremia . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
23,
32
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
74,
77
]
} |
this was accomplished through the use of anti-apo [ a ] as a capture antibody and quantitation of the bound lp [ a ] , i.e. , the apob-100-apo [ a ] complex , with an anti-apob antibody . | NA | {
"id": "C0205666",
"name": "apob-100",
"pos": [
130,
138
]
} | {
"id": "C0003593",
"name": "apob",
"pos": [
172,
176
]
} |
also , other cholesterol esterifying enzymes such as lecithin : cholesterol acyltransferase ( lcat ) and pancreatic cholesterol esterase were not inhibited by i , nor was esterification of retinol by acyl coa : retinol acyltransferase ( arat ) from intestinal mucosal microsomes inhibited . | NA | {
"id": "C0008380",
"name": "cholesterol",
"pos": [
13,
24
]
} | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
219,
234
]
} |
also , other cholesterol esterifying enzymes such as lecithin : cholesterol acyltransferase ( lcat ) and pancreatic cholesterol esterase were not inhibited by i , nor was esterification of retinol by acyl coa : retinol acyltransferase ( arat ) from intestinal mucosal microsomes inhibited . | NA | {
"id": "C0023194",
"name": "cholesterol",
"pos": [
13,
24
]
} | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
219,
234
]
} |
the unstable carboxypeptidase differs from carboxypeptidase n in ph-optimum , esterase activity , substrate specificity , co2+-activation and dithiotreitol activation . | NA | {
"id": "C0007075",
"name": "carboxypeptidase",
"pos": [
13,
29
]
} | {
"id": "C0003766",
"name": "carboxypeptidase",
"pos": [
43,
59
]
} |
newly molted last instar nymphs were treated with methoprene , a juvenile hormone analog , and examined four days following the next molt . | NA | {
"id": "C0025674",
"name": "methoprene",
"pos": [
50,
60
]
} | {
"id": "C0022439",
"name": "juvenile hormone",
"pos": [
65,
81
]
} |
time-since-death estimations are usually based on physical decomposition of the corpse , insect succession , and contextual associations . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
11,
16
]
} | {
"id": "C0006629",
"name": "corpse",
"pos": [
80,
86
]
} |
the 5-ht1a [ 5-hydroxytryptamine ( serotonin ) type 1a ] receptor agonists 8-hydroxy-2- ( di-n-propylamino ) tetralin and buspirone mimic the serotonin response in reducing the forskolin-stimulated cyclic amp levels , as do the indole derivatives 5-methoxytryptamine , 5-hydroxtryptophan , and tryptamine . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
35,
44
]
} | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
249,
266
]
} |
we have examined the binding of the adenosine agonist radioligands [ 3h ] cyclohexyladenosine [ ( 3h ] cha ) , r-n6- [ 3h ] phenylisopropyladenosine [ ( 3h ] r-pia ) , and 5'-n-ethylcarboxamido [ 3h ] adenosine [ ( 3h ] neca ) to membranes prepared from rat pineal gland . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
124,
148
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
201,
210
]
} |
we have examined the binding of the adenosine agonist radioligands [ 3h ] cyclohexyladenosine [ ( 3h ] cha ) , r-n6- [ 3h ] phenylisopropyladenosine [ ( 3h ] r-pia ) , and 5'-n-ethylcarboxamido [ 3h ] adenosine [ ( 3h ] neca ) to membranes prepared from rat pineal gland . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
36,
45
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
220,
224
]
} |
the rank of activity of adenosine analogues in displacing specific [ 3h ] neca binding was neca greater than 2-chloroadenosine greater than s-adenosyl-l-homocysteine greater than cha . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
24,
33
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
91,
95
]
} |
at this time , the increases of inositol 1,4,5-trisphosphate ( measured by hplc ) were relatively larger with respect to the other ins-ps . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
32,
40
]
} | {
"id": "C0021554",
"name": "ins-ps",
"pos": [
131,
137
]
} |
both cell cultures contain adenylate cyclase stimulated by catecholamines with a potency order of isoprenaline greater than adrenaline greater than salbutamol much greater than noradrenaline , which is consistent with the presence of beta 2-adrenergic receptors . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
59,
73
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
98,
110
]
} |
both cell cultures contain adenylate cyclase stimulated by catecholamines with a potency order of isoprenaline greater than adrenaline greater than salbutamol much greater than noradrenaline , which is consistent with the presence of beta 2-adrenergic receptors . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
124,
134
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
177,
190
]
} |
the formation of camp in nep2 is also stimulated by 5'- ( n-ethylcarboxamido ) adenosine ( neca ) more potently than by either adenosine or n6- ( l-phenylisopropyl ) adenosine ( l-pia ) , which suggests that this foetal astrocyte expresses adenosine a2 receptors . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
91,
95
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
240,
249
]
} |
fluorescence-activated cell sorting based on immunolabeling with a monoclonal antibody to tyrosine hydroxylase and a fluorescein-conjugated secondary antibody was used to identify striatal synaptosomes derived from nigrostriatal dopamine nerve terminals . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
67,
77
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
150,
158
]
} |
although the absolute number of dopaminergic synaptosomes was decreased in lesioned animals , those residual dopamine terminals present contained more tyrosine hydroxylase than did dopamine terminals from control rats . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
32,
44
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
181,
189
]
} |
further studies showed that the subcellular distribution of [ 14c ] dopamine was identical to that of norepinephrine and epinephrine and that the accumulated [ 14c ] dopamine could be converted to norepinephrine within the chromaffin vesicle if dopamine uptake was blocked . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
105,
116
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
197,
211
]
} |
previous biochemical studies have shown that the accumulation of the major pns myelin proteins , p0 and myelin basic protein ( mbp ) , is strongly diminished in trembler sciatic nerves during postnatal development . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
79,
94
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
104,
124
]
} |
however , we did not find either epinephrine or norepinephrine , endogenous ligands of the beta-receptor , to be present in retinal extracts subjected to hplc . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
33,
44
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
48,
62
]
} |
neither effect was likely to be due to dihydropyridine ( dhp ) binding to baclofen recognition sites , because the inhibitory ligand nifedipine primarily affected apparent receptor density rather than affinity . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
39,
54
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
133,
143
]
} |
both gaba and baclofen , but not isoguvacine , altered beta ar agonist binding by increasing the affinity of both the low- and high-affinity binding sites and by increasing the proportion of low-affinity receptors . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
5,
9
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
14,
22
]
} |
the response to baclofen was stereoselective , and the effect of gaba was not inhibited by bicuculline . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
16,
24
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
65,
69
]
} |
the effect of levodopa ( l-dopa ) , alone or in combination with a peripheral decarboxylase inhibitor ( pdi ) , on plasma levels of aromatic-l-amino acid decarboxylase ( alaad , = dopa decarboxylase ) , l-dopa , 3-o-methyl-dopa ( 3-omd ) , dopamine ( da ) , noradrenaline , adrenaline and dopamine beta-hydroxylase has been studied . | NA | {
"id": "C1412028",
"name": "aromatic-l-amino acid",
"pos": [
132,
153
]
} | {
"id": "C0003806",
"name": "dopa decarboxylase",
"pos": [
180,
198
]
} |
the effect of levodopa ( l-dopa ) , alone or in combination with a peripheral decarboxylase inhibitor ( pdi ) , on plasma levels of aromatic-l-amino acid decarboxylase ( alaad , = dopa decarboxylase ) , l-dopa , 3-o-methyl-dopa ( 3-omd ) , dopamine ( da ) , noradrenaline , adrenaline and dopamine beta-hydroxylase has been studied . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
258,
271
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
274,
284
]
} |
in contrast to anti-viral antibodies , anti-mbp and gm1 antibodies belonged to igg1 , igg3 or igg4 in ms . | NA | {
"id": "C0003253",
"name": "anti-viral antibodies",
"pos": [
15,
36
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
56,
66
]
} |
a 35-year-old female patient suffering from epilepsy was examined during status epilepticus with simple partial and complex partial seizures by means of eeg , ct , mri and ictal spect . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
44,
52
]
} | {
"id": "C0038220",
"name": "status",
"pos": [
73,
79
]
} |
in a prospective study , 30 pregnant epileptic patients were followed through their pregnancy to determine the effect of seizures on pregnancy and its outcome and the effect of pregnancy on seizures . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
37,
46
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
190,
198
]
} |
thus blood pressure of young adults is related to blood pressure in adolescence , relative weight and change in relative weight since adolescence , and in males to age of maturation as determined by the age at which adult height is attained . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
91,
97
]
} | {
"id": "C0005911",
"name": "change in",
"pos": [
102,
111
]
} |
the purpose of the present study is to make predictions about the relative and the real time duration of cellular events during vascular invasion , including an analysis of the time sequence of death of the terminal hypertrophic chondrocyte . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
105,
113
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
229,
240
]
} |
cellular condensation lasts approximately 45 min or 18 % of the time a cell spends as a terminal chondrocyte . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
97,
108
]
} |
by regression analyses of the maximum values of each rotation in each curve , the rotation of the apex vertebra was found to be generally of lesser magnitude than the rotation of the plane of maximum curvature of the spine and in an opposite sense in kyphotic curves . | NA | {
"id": "C0037932",
"name": "of",
"pos": [
23,
25
]
} | {
"id": "C0022821",
"name": "kyphotic",
"pos": [
251,
259
]
} |
the two materials were compared statistically in order to see whether any difference in the frequency of alcoholism and alcohol related brain disorders could be demonstrated between the geographic areas served by these two hospitals . | NA | {
"id": "C0001973",
"name": "alcoholism",
"pos": [
105,
115
]
} | {
"id": "C0236664",
"name": "alcohol related",
"pos": [
120,
135
]
} |
catalysis of the encapsulated enzyme was investigated , and the hydrolysis of triacetin ( triglyceride of acetic acid ) was successfully simulated by the reaction model based upon the michaelis-menten mechanism . | NA | {
"id": "C0040853",
"name": "triacetin",
"pos": [
78,
87
]
} | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
90,
102
]
} |
these results suggest that the signalling transduction of mu- and delta-agonists is partially mediated by the adenylate cyclase system coupled with opioid receptors , but that kappa-receptors may not be associated with adenylate cyclase . | NA | {
"id": "C0034801",
"name": "opioid receptors",
"pos": [
148,
164
]
} | {
"id": "C0064239",
"name": "kappa-receptors",
"pos": [
176,
191
]
} |
the metabolism and excretion of trimethadione in patients with percutaneous transhepatic biliary drainage and renal dysfunction . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
the metabolism and excretion of trimethadione ( tmo ) following an oral dose of 4 mg/kg has been examined in patients with percutaneous transhepatic biliary drainage ( ptbd ) and renal dysfunction . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
alpha-blocking potencies of antihypertensive agents ( prazosin , terazosin , bunazosin , sgb-1534 and ketanserin ) having with quinazoline or quinazolinedione as assessed by radioligand binding assay methods in rat brain . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
54,
62
]
} | {
"id": "C0076107",
"name": "terazosin",
"pos": [
65,
74
]
} |
alpha-blocking potencies of antihypertensive agents ( prazosin , terazosin , bunazosin , sgb-1534 and ketanserin ) having with quinazoline or quinazolinedione as assessed by radioligand binding assay methods in rat brain . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
54,
62
]
} | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
142,
153
]
} |
the comparative effects of antihypertensive agents , quinazoline or quinazolinedione residues ( prazosin , bunazosin , terazosin , sgb-1534 , and ketanserin ) , on the binding of [ 3h ] prazosin , [ 3h ] p-aminoclonidine and [ 3h ] dihydroalprenolol ( [ 3h ] dha ) to alpha 1- , alpha 2- , and beta-adrenoceptors in the rat brain were examined using radioligand binding assay methods . | NA | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
53,
64
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
186,
194
]
} |
the comparative effects of antihypertensive agents , quinazoline or quinazolinedione residues ( prazosin , bunazosin , terazosin , sgb-1534 , and ketanserin ) , on the binding of [ 3h ] prazosin , [ 3h ] p-aminoclonidine and [ 3h ] dihydroalprenolol ( [ 3h ] dha ) to alpha 1- , alpha 2- , and beta-adrenoceptors in the rat brain were examined using radioligand binding assay methods . | NA | {
"id": "C0076107",
"name": "terazosin",
"pos": [
119,
128
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
186,
194
]
} |
the rank order of antagonistic potencies of these drugs against the alpha 1-adrenergic receptors was determined by inhibition constants ( ki ) with sgb-1534 = prazosin = bunazosin greater than terazosin greater than ketanserin . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
159,
167
]
} | {
"id": "C0076107",
"name": "terazosin",
"pos": [
193,
202
]
} |
this study examined whether normal newborn infants had a preference for 5 % glucose and water or sterile water for their first feedings . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
88,
93
]
} | {
"id": "C0359299",
"name": "sterile water",
"pos": [
97,
110
]
} |
when the bagasse-derived cellulose was reconstituted by recombining different proportions of selected sieve cuts to have a similar sieve size distribution as the commercially available mcc , avicel ph102 , it was found that the latter and diceb iii also had similar crystallinity as measured by x-ray powder diffraction ( degree of crystallinity 2.8 +/- 0.2 ) . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
25,
34
]
} | {
"id": "C0669247",
"name": "mcc",
"pos": [
185,
188
]
} |
second , the effects of an adenosine receptor antagonist , 1,3-dipropyl-8-p-sulfophenylxanthine , on aii-induced potentiation of vascular responses to pns and on aii-induced direct vasoconstriction were examined . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
101,
104
]
} | {
"id": "C0003018",
"name": "aii",
"pos": [
162,
165
]
} |
the dihydropyridine calcium channel antagonists nicardipine ( 1 microm ) or nifedipine ( 1 microm ) , and also diltiazem ( 1 microm ) , had little or no effect on endothelin concentration-response curves . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel antagonists",
"pos": [
4,
47
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
48,
59
]
} |
the dihydropyridine calcium channel antagonists nicardipine ( 1 microm ) or nifedipine ( 1 microm ) , and also diltiazem ( 1 microm ) , had little or no effect on endothelin concentration-response curves . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel antagonists",
"pos": [
4,
47
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
76,
86
]
} |
thus , the profile of the striatal m2 receptor obtained with these antagonists did not match in all respects with either glandular ( probable m4 gene product ) or cardiac ( probable m2 gene product ) muscarinic receptors . | NA | {
"id": "C0384752",
"name": "m2 receptor",
"pos": [
35,
46
]
} | {
"id": "C0034826",
"name": "muscarinic receptors",
"pos": [
200,
220
]
} |
in vivo studies demonstrate further that the total number of muscarinic receptors was decreased significantly , whereas putative m2 receptors , measured directly with the agonist [ 3h ] oxotremorine-m or estimated by pirenzepine- [ 3h ] quinuclidinyl benzilate competition , were unchanged . | NA | {
"id": "C0034826",
"name": "muscarinic receptors",
"pos": [
61,
81
]
} | {
"id": "C0384752",
"name": "m2 receptors",
"pos": [
129,
141
]
} |
the gabab receptor agonist ( - ) -baclofen , but not the gabaa receptor agonist muscimol , mimicked gaba and produced a concentration-inhibition curve almost superimposable to that of the natural transmitter . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
34,
42
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
100,
104
]
} |
in the present study , we examined the effects of l-norepinephrine ( ne ) and selective alpha-1 , alpha-2 and beta adrenergic agonists on monovalent cation transport and on na+-k+-adenosine triphosphatase ( atpase ) activity from homogenates , intact tubules and highly purified basolateral membranes prepared from superficial rabbit kidney cortex . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
173,
175
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
207,
213
]
} |
we have assessed the ability of thiorphan , an inhibitor of enkephalinase , to influence the potentiation of the nerve-mediated contractions of the rat isolated vas deferens ( pars prostatica ) by mammalian tachykinins [ substance p , ( sp ) ; neurokinin a ( nka ) ; and neurokinin b ( nkb ) ] and selective tachykinin agonists . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
221,
232
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
308,
318
]
} |
we have assessed the ability of thiorphan , an inhibitor of enkephalinase , to influence the potentiation of the nerve-mediated contractions of the rat isolated vas deferens ( pars prostatica ) by mammalian tachykinins [ substance p , ( sp ) ; neurokinin a ( nka ) ; and neurokinin b ( nkb ) ] and selective tachykinin agonists . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
244,
256
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
308,
318
]
} |
we have assessed the ability of thiorphan , an inhibitor of enkephalinase , to influence the potentiation of the nerve-mediated contractions of the rat isolated vas deferens ( pars prostatica ) by mammalian tachykinins [ substance p , ( sp ) ; neurokinin a ( nka ) ; and neurokinin b ( nkb ) ] and selective tachykinin agonists . | NA | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
271,
283
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
308,
318
]
} |
in the absence of thiorphan , the rank order of potency of mammalian tachykinins was nka greater than nkb much greater than sp . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
69,
80
]
} | {
"id": "C0038581",
"name": "nka",
"pos": [
85,
88
]
} |
in the absence of thiorphan , the rank order of potency of mammalian tachykinins was nka greater than nkb much greater than sp . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
69,
80
]
} | {
"id": "C0027847",
"name": "nkb",
"pos": [
102,
105
]
} |
in the absence of thiorphan , the rank order of potency of mammalian tachykinins was nka greater than nkb much greater than sp . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
69,
80
]
} | {
"id": "C0038585",
"name": "sp",
"pos": [
124,
126
]
} |
we propose that macrolides may be classified into three groups , those forming complexes when given alone ( e.g. , erythromycin and troleandomycin ) , those forming complexes only in glucocorticoid-pretreated rats ( clarithromycin and roxithromycin ) and those not forming complexes ( josamycin , midecamycin and spiramycin ) . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
115,
127
]
} | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
216,
230
]
} |
we propose that macrolides may be classified into three groups , those forming complexes when given alone ( e.g. , erythromycin and troleandomycin ) , those forming complexes only in glucocorticoid-pretreated rats ( clarithromycin and roxithromycin ) and those not forming complexes ( josamycin , midecamycin and spiramycin ) . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
115,
127
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
235,
248
]
} |
acid-etched cast metal resin-bonded retainers require resin luting agents with film thicknesses similar to dental cements to allow complete seating of frameworks without the need for post-bonding adjustments . | NA | {
"id": "C0376523",
"name": "resin luting agents",
"pos": [
54,
73
]
} | {
"id": "C1706094",
"name": "dental cements",
"pos": [
107,
121
]
} |
a group of 14 ewes was actively immunized against oxytocin coupled to carrier protein , and comparisons of the reproductive status of these animals were made against ewes immunized against carrier protein only ( n = 5 ) and untreated controls ( n = 6 ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
78,
85
]
} | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
189,
204
]
} |
these studies suggest that the synergic relationship between bacteria in polymicrobial infections is a complex one , resulting from intimate interactions between bacteria and the host in the local milieu of the infection . | NA | {
"id": "C0275524",
"name": "polymicrobial infections",
"pos": [
73,
97
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
211,
220
]
} |
virus derived from cells transfected with this clone is cytopathic for rhesus peripheral blood mononuclear cells , replicates in cultures of rhesus macrophages , and infects rhesus macaques when inoculated intravenously . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
19,
24
]
} | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
78,
94
]
} |
of the remaining analytes , hexachlorobenzene ( hcb ) , trans-nonachlor ( tnc ) , and heptachlor epoxide ( he ) were found at quantifiable concentrations in 1-10 % of the specimens , whereas o , p'-ddt , o , p'-dde , p , p'-ddd , mirex , alpha-bhc , gamma-bhc , heptachlor , delta-bhc , and aldrin were found in less than 1 % of the serum specimens . | NA | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
86,
104
]
} | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
262,
272
]
} |
the time course of production and release of nerve growth factor ( ngf ) and non-ngf neuronotrophic factors for sympathetic neurons by chicken and rat sciatic nerves in culture was examined . | NA | {
"id": "C0027752",
"name": "nerve growth factor",
"pos": [
45,
64
]
} | {
"id": "C0027754",
"name": "neuronotrophic factors",
"pos": [
85,
107
]
} |
affinity-purified antimouse ngf antibodies were used to show that sciatic nerves in culture release both ngf and non-ngf trophic factors . | NA | {
"id": "C0027752",
"name": "ngf",
"pos": [
28,
31
]
} | {
"id": "C0027754",
"name": "ngf",
"pos": [
117,
120
]
} |
these studies therefore characterize antibodies recognizing chicken ngf , demonstrate that peripheral nerve tissue synthesize trophic factors other than ngf , and identify factors that influence ngf synthesis . | NA | {
"id": "C0027754",
"name": "factors",
"pos": [
134,
141
]
} | {
"id": "C0027752",
"name": "ngf",
"pos": [
195,
198
]
} |
a similar polypeptide band ( mr 45,000-60,000 ) was identified on immunoblots of microvessel membrane proteins isolated from canine cerebrum , suggesting that this antibody is a useful tool for studying the distribution and abundance of the glucose transporter protein in mammalian nervous tissue . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
93,
110
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
261,
268
]
} |
preinjury psychopathology in trauma patients was commonly present and seemed to be most highly associated with penetrating trauma and alcohol use . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
29,
35
]
} | {
"id": "C0043254",
"name": "penetrating trauma",
"pos": [
111,
129
]
} |
three cases of acute viral hepatitis are reported with various cardiac changes such as transient left ventricular hypertrophy , myocarditis and progressive cardiomegaly ( cardiomyopathy ) . | NA | {
"id": "C0149721",
"name": "left ventricular hypertrophy",
"pos": [
97,
125
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
156,
168
]
} |
three cases of acute viral hepatitis are reported with various cardiac changes such as transient left ventricular hypertrophy , myocarditis and progressive cardiomegaly ( cardiomyopathy ) . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
128,
139
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
171,
185
]
} |
the function of the a element ( nucleotides 5107 to 5130 ) of the polyomavirus enhancer is augumented in nih 3t3 cells by a tumor-promoting phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
140,
153
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
156,
192
]
} |
comparison of the locations of piv3 neutralization epitopes with those of newcastle disease and sendai viruses indicated that the antigenic organization of the fusion proteins of paramyxoviruses is similar . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
51,
59
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
130,
139
]
} |
taking into account data on protein composition , we conclude that the difference between their masses is essentially contributed by viral protein 22 ( 46 kda ) , which is an integral component of the maturable intermediate nucleocapsid but not of the abortive light nucleocapsid . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0042736",
"name": "viral protein",
"pos": [
133,
146
]
} |
by using an antiserum raised against procaryote-expressed parts of the cytomegalovirus membrane protein , a 45-kilodalton structural component of the virus was identified as the gene product . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
87,
103
]
} | {
"id": "C0033684",
"name": "gene",
"pos": [
178,
182
]
} |
through immunoprecipitation analysis of the viral soluble protein pool , we found that a complex that usually exists between the n and ns proteins at ph 7.4 was altered in extracts from infected cells maintained at ph 6.6 , and this was responsible for the observed effects on viral replication . | NA | {
"id": "C0042736",
"name": "viral",
"pos": [
44,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
138,
146
]
} |
to determine how these leader orfs affect synthesis of the virion proteins , monkey cells were transfected with viral mutants in which either the leader-encoded translation initiation signal was mutated or the length and overlap of the leader orf relative to the orfs encoding the virion proteins were altered . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
42,
51
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
288,
296
]
} |
we demonstrate that in mksa cells ( sv40-transformed balb/c mouse fibroblasts ) , total pm-associated large t accounted for a substantial portion ( ca . 2 % ) of total cellular large t . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
66,
77
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
168,
176
]
} |
the previously described poliovirus-associated protein kinase activity phosphorylates viral proteins vp0 and vp2 as well as exogenous proteins in the presence of mg2+ . | NA | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
86,
100
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
134,
142
]
} |
therefore , we conclude that the primary gene 11 product is a nonstructural phosphoprotein which we designated ns26 . | NA | {
"id": "C0033684",
"name": "gene",
"pos": [
41,
45
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
76,
90
]
} |
since maximum binding was observed with human foreskin fibroblasts ( hff ) , interactions of radiolabeled hcmv with this cell type were analyzed quantitatively . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cell type",
"pos": [
121,
130
]
} |
latent infection of established ebv-negative burkitt 's lymphoma cell lines with the transforming ebv strain , b95-8 , resulted in dramatic increases in vimentin mrna and protein levels , while infection with the nontransforming p3hr1 strain failed to do so . | NA | {
"id": "C0149678",
"name": "infection",
"pos": [
7,
16
]
} | {
"id": "C0006413",
"name": "burkitt 's",
"pos": [
45,
55
]
} |
whereas extraanatomic bypass is generally considered the procedure of choice for an infected abdominal aneurysm , the aneurysms of our patient and three other patients cited in the literature were reconstructed with anatomically placed prosthetic grafts . | NA | {
"id": "C0002950",
"name": "infected",
"pos": [
84,
92
]
} | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
118,
127
]
} |
serotonin receptors ( 5-ht1 and 5-ht2 ) were investigated in the cortex and hippocampus by radioligand binding studies using 3h-serotonin for analysis of 5-ht1-receptors and 3h-ketanserin for analysis of 5-ht2-receptors . | NA | {
"id": "C0034838",
"name": "serotonin receptors",
"pos": [
0,
19
]
} | {
"id": "C0753726",
"name": "serotonin",
"pos": [
128,
137
]
} |
p : ns ) , plasma concentrations of gastrointestinal hormones ( gastrin : preprandial before/after lipids : 14 +/- 2.1/13 +/- 1.4 pm ; | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
36,
52
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
64,
71
]
} |
the nutritional indices which reliably predicted preoperatively the nutritional status of cancer patients were the serum protein concentrations including the serum albumin ( alb ) and prealbumin ( pa ) . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
158,
171
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
184,
194
]
} |
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