text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
azelaic acid ( az ) , a straight saturated chain nine carbon dicarboxylic acid , was administered in saline form to six healthy male volunteers by iv route . | NA | {
"id": "C0052761",
"name": "azelaic acid",
"pos": [
0,
12
]
} | {
"id": "C0012063",
"name": "dicarboxylic acid",
"pos": [
61,
78
]
} |
these results suggest that the respiratory responses to exercise are not affected by the higher level of [ hco3- ] induced by nahco3 ingestion , and appear to reflect the net change of plasma [ hco3- ] or [ h+ ] . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
126,
132
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
194,
198
]
} |
light and electron microscopic examinations revealed that the original and serially transplanted tumors were composed of an admixture of fibroblast-like and histiocyte-like cells arranged in a storiform pattern . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
137,
147
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
escherichia coli bacteremia and endotoxemia were observed in 3 adult mongrel dogs which had been prediagnosed as canine parvoviral disease . | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
17,
27
]
} | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
32,
43
]
} |
in a serum-free medium [ ham 's f-12 : eagle 's minimum essential medium ( 1:1 , vol/vol ) containing 0.1 % bovine serum albumin ] , the proliferation of sc-3 cells ( a cloned cell line from sc115 cells ) estimated by [ 3h ] thymidine incorporation into dna and cell number reached a plateau at 10 ( -8 ) m testosterone ( up to 200-fold ) , 10 ( -7 ) m dexamethasone ( up to 30-fold ) or 1 ng/ml of fibroblast growth factors ( fgf ; up to 50-fold ) . | NA | {
"id": "C0079349",
"name": "1",
"pos": [
34,
35
]
} | {
"id": "C0016026",
"name": "fgf",
"pos": [
427,
430
]
} |
furthermore , an epithelial appearance of sc-3 cells grown in the absence of growth factors or steroids was changed to a fibroblast-like appearance only by the addition of testosterone , high concentrations of dexamethasone or fgf . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
121,
131
]
} |
electroacupuncture ( ea ) at 05:00 increased the mek content in the medulla oblongata plus pons and the lek level in the hypothalamus . | NA | {
"id": "C0014295",
"name": "mek",
"pos": [
49,
52
]
} | {
"id": "C0014298",
"name": "lek",
"pos": [
104,
107
]
} |
it decreased the mek content in the hypothalamus and the lek level in the cortex ; | NA | {
"id": "C0014295",
"name": "mek",
"pos": [
17,
20
]
} | {
"id": "C0014298",
"name": "lek",
"pos": [
57,
60
]
} |
at 17:00 it increased the mek level in the hypothalamus and the lek content in the hippocampus . | NA | {
"id": "C0014298",
"name": "mek",
"pos": [
26,
29
]
} | {
"id": "C0014294",
"name": "lek",
"pos": [
64,
67
]
} |
the nfs/n1.h7 cell line was strictly dependent upon il-3 for growth , and the cell line could be activated by phorbol esters ( pma ) to augment il-3 dependent proliferation , but when pkc was downregulated , diminished il-3 proliferative response resulted . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
110,
124
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
127,
130
]
} |
the uptake and distribution of three common dietary polyunsaturated fatty acids was studied using chinese hamster lung fibroblasts ( v79 cells ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
119,
130
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
137,
142
]
} |
effects of cholesterol oxidation derivatives on cholesterol esterifying and cholesteryl ester hydrolytic enzyme activity of cultured rabbit aortic smooth muscle cells . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
11,
22
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
76,
93
]
} |
the holoenzyme has similar properties in respect of ( i ) and ( ii ) but behaves differently during anion exchange . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
20,
21
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
100,
105
]
} |
the previously described selective reduction of the first-phase response in type ii diabetes may be partly a function of the bolus intravenous glucose tests used , in which impaired glucose tolerance in the diabetics gave a greater glycemic stimulus to the second phase than in normal subjects , and partly secondary to long-term hyperglycemia . | NA | {
"id": "C0271650",
"name": "impaired glucose tolerance",
"pos": [
173,
199
]
} | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
330,
343
]
} |
the diabetic subjects were re-studied after treatment with a sulphonylurea , gliclazide , with a normal fasting plasma glucose , mean 5.1 mmol/l . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
61,
74
]
} | {
"id": "C0017631",
"name": "gliclazide",
"pos": [
77,
87
]
} |
this 86rb ( k ) influx was stimulated by adrenaline , isoprenaline , and salbutamol , but noradrenaline caused a mild inhibition . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
41,
51
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
90,
103
]
} |
plasma levels of glutamine and alanine approximately doubled compared with preinfusion levels , indicating a release of these amino acids from the dipeptide . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
31,
38
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
126,
137
]
} |
to elucidate the molecular principles of serological inhomogeneity of the species the immunochemical studies of lipopolysaccharides of a number of p. cepacia strains have been conducted and the structure has been determined for repeating links of o-specific polysaccharides of p. cepacia strains attributed to 4 nakamura serogroups , 3 heidt serogroups , to serogroups k and l , as well as for certain strains from the collection of the institute of microbiology and virology of the ukr . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
112,
131
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharides",
"pos": [
247,
273
]
} |
s. citreofluorescens dna showed a 55 % homology with reference s. chrysomallus dna , which corresponded to the range of interspecies hybridization . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
21,
24
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
141,
142
]
} |
to investigate whether the lack of overt bicarbonaturia was due to the reduced filtered load of hco3 or to a stimulatory effect of acidemia on distal hco3 reabsorption , blood bicarbonate was elevated by the infusion of nahco3 . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
96,
100
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
220,
226
]
} |
intact animals treated with increasing doses of nahco3 revealed a statistically significant inverse correlation between the mg to na clearance ratio and urinary and plasma bicarbonate concentration . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
48,
54
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
172,
183
]
} |
this obliges us to rethink the role of the hyperinsulinism encountered in pcos and suggests that the changed sensitivity of the peripheral tissues to insulin activity may constitute a primary event in the genesis of insulin-resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
43,
58
]
} | {
"id": "C0021655",
"name": "insulin-resistance",
"pos": [
216,
234
]
} |
medium chain triglyceride emulsion ( mct ) which is composed of 10 % emulsion of tricaprylin ( c8 ) or long chain triglyceride emulsion ( lct , 10 % intralipos ) was infused intravenously to 20 rabbits for a period of 180 min ( n = 10 ; mct , n = 10 ; lct ) . | NA | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
13,
25
]
} | {
"id": "C0724624",
"name": "mct",
"pos": [
237,
240
]
} |
tegafur ( ft ) is a masked compound of 5-fluorouracil ( 5-fu ) and supposed to be activated in the liver . | NA | {
"id": "C0016778",
"name": "tegafur",
"pos": [
0,
7
]
} | {
"id": "C0016360",
"name": "5-fu",
"pos": [
56,
60
]
} |
mice were transplanted with human gastric ( gc-sf ) or colonic cancer ( cc-zk ) lines , and daily administered intragastrically with 5-fu ( 15mg/kg ) , ft ( 100mg/kg ) or uft ( ft 20mg/kg + uracil 44.8mg/kg ) for 4 weeks . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
135,
137
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
190,
196
]
} |
we have examined whether a precursor form of nf-kappa b , a dna-binding protein that plays a role in the transcriptional control of several genes , including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit , could be activated in vitro by protein kinases . | NA | {
"id": "C0079904",
"name": "nf-kappa b",
"pos": [
45,
55
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
60,
79
]
} |
these mutants , however , were unable to transform established rat fibroblasts ( rat-1a cells ) that were susceptible to transformation by wild-type c-myc , although this lack of activity may not have been due to their inability to bind dna . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
67,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} |
the cytotoxic cells that killed the nk-resistant target cells in a 24-hour assay were plastic- and nylon wool-nonadherent human peripheral blood mononuclear cells ( pbmc ) and their cytotoxicity was increased by interferon-alpha , interferon-gamma , and interleukin-2 . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
86,
93
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
99,
104
]
} |
plastic-adherent lymphokine-activated natural killer ( lank ) cells were generated from nylon wool-nonadherent murine splenocytes cultured in recombinant interleukin-2 ( il-2 ) . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
0,
7
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
88,
93
]
} |
similar inhibitory actions of hemin on several other direct-acting aminoazaarene mutagens are also described , as well as the inhibition activities of protoporphyrin , chlorophyllin , biliverdin and bilirubin . | NA | {
"id": "C0005446",
"name": "biliverdin",
"pos": [
184,
194
]
} | {
"id": "C0005437",
"name": "bilirubin",
"pos": [
199,
208
]
} |
we observed increases in the relative synthesis of the putative heat-shock proteins of 82 and 70 kda and of proteins of 79 and 41 kda but decreases in the synthesis of proteins of 38 and 28 kda . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
75,
83
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
155,
164
]
} |
severe hyponatremia occurs in some patients with untreated hypopituitarism , but it is not known whether such hyponatremia is caused by the hypersecretion of vasopressin ( antidiuretic hormone ) . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
158,
169
]
} | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
172,
192
]
} |
we report the results of the ticlopidine aspirin stroke study , a blinded trial at 56 north american centers that compared the effects of ticlopidine hydrochloride ( 500 mg daily ) with those of aspirin ( 1300 mg daily ) on the risk of stroke or death . | NA | {
"id": "C0040207",
"name": "ticlopidine",
"pos": [
29,
40
]
} | {
"id": "C0000598",
"name": "ticlopidine",
"pos": [
138,
149
]
} |
for slightly overweight women ( relative weight , 24 to 24.9 kg per square meter ) , the relative risk was 1.7 ( 95 percent confidence interval , 1.1 to 2.7 ) . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
13,
23
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
41,
47
]
} |
the reservoir is refilled transcutaneously every two months with a surfactant-stabilized human insulin preparation containing 400 u of insulin per milliliter . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
89,
102
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
135,
142
]
} |
the effect on the d- [ 3h ] aspartate release of the two gamma-aminobutyric acid ( gaba ) agonists 4,5,6,7-tetrahydroisoxazolo [ 5,4-c ] -pyridin-3-ol ( thip ) and ( +/- ) -beta- ( p-chlorophenyl ) gaba ( baclofen ) , which specifically activate gabaa and gabab receptors , respectively , was studied . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
83,
87
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
205,
213
]
} |
potent inhibition ( ki approximately km ) of transport in each system was exhibited by l-cysteate , and l- and d-cysteine sulphinate whereas substantially weaker inhibitory effects ( ki greater than 10-1000 times the appropriate km value ) were exhibited by the remaining sulphur amino acids . | NA | {
"id": "C0010652",
"name": "cysteate",
"pos": [
89,
97
]
} | {
"id": "C0002527",
"name": "sulphur amino acids",
"pos": [
272,
291
]
} |
both soluble and membrane proteins were modified by myristate in a hydroxylamine-stable ( amide ) linkage , while palmitoylated proteins were ester-linked and almost exclusively membrane bound . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
17,
34
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
128,
136
]
} |
the role of membrane protein in the incorporation of exogenous gm1 could not be explained by the lytic release of cytosolic transfer proteins nor the artifactual coating of the cell surface by serum proteins . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
12,
28
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
199,
207
]
} |
taurine ( tau ) and the small neutral amino acids glycine ( gly ) , serine ( ser ) , threonine ( thr ) , and alanine ( ala ) were measured in 53 brain areas of 3- and 29-month-old male fisher 344 rats . | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
30,
49
]
} | {
"id": "C0036720",
"name": "serine",
"pos": [
68,
74
]
} |
in the most malignant tumours radiosurgery resulted in a decrease in spermine and an increase in spermidine levels . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
69,
77
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
108,
114
]
} |
gamma-aminobutyric acid and ( - ) -baclofen , but not ( + ) -baclofen , produced a dose-dependent inhibition of the potassium-stimulated [ ca2+ ] i in cortical synaptosomes from the rat . | NA | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
0,
23
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
61,
69
]
} |
the high seizure susceptibility is not due to abnormalities in the nmda receptor as comparison of kd , bmax and ki values in synaptosomal preparations from epileptic and non-epileptic chickens indicated no differences in nmda receptor binding receptor characteristics . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
9,
16
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
174,
183
]
} |
284 suffered from major depression ( md ) ( including major depressive disorder and bipolar disorder , depressed ; dsm iii ) and 114 from minor depression ( mid ) including dysthymic disorder , atypical depression and adjustment disorder with depressive mood ( dsm iii ) . | NA | {
"id": "C0013415",
"name": "dysthymic disorder",
"pos": [
173,
191
]
} | {
"id": "C0011581",
"name": "disorder",
"pos": [
229,
237
]
} |
single and double indirect immunofluorescence using antibodies against the myelin glycolipids , galactocerebroside and sulfatide , and the myelin proteins , myelin basic protein and 2',3'-cyclic nucleotide 3'-phosphohydrolase , was used to investigate the composition of the flat membrane extensions produced by some oligodendrocytes in culture . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
139,
154
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
157,
177
]
} |
calbindin d-28k is a calcium-binding protein which is not expressed by dorsal root ganglion cells cultured from 6-day-old ( e6 ) chick embryos . | NA | {
"id": "C0054444",
"name": "calbindin",
"pos": [
0,
9
]
} | {
"id": "C0006732",
"name": "calcium-binding protein",
"pos": [
21,
44
]
} |
dopamine d1 receptor binding sites labeled by the d1 specific antagonist [ 3h ] sch 23390 were studied in the striatum of 7-day and adult homozygous weaver ( wv/wv ) and homozygous control ( +/+ ) mice . | NA | {
"id": "C0034798",
"name": "dopamine",
"pos": [
0,
8
]
} | {
"id": "C0058697",
"name": "d1 receptor",
"pos": [
9,
20
]
} |
hematologic and hepatic abnormalities were significantly associated with az , but serious non-ms abnormalities were uncommon and were equally distributed among the 3 groups . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
24,
37
]
} | {
"id": "C0000772",
"name": "ms",
"pos": [
94,
96
]
} |
a clinical case of splenosis recently observed in a young man subjected at the age of 8 to splenectomy for rupture of the spleen and operated at 19 for intestinal occlusion is reported . | NA | {
"id": "C0206369",
"name": "splenosis",
"pos": [
19,
28
]
} | {
"id": "C0038000",
"name": "rupture of",
"pos": [
107,
117
]
} |
the in vivo dopaminergic neurotoxicity of a series of quinoline and isoquinoline derivatives was assessed in rats using an intrastriatal microdialysis technique that measures the release of dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
12,
24
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
190,
198
]
} |
however , the maximal uptake level was much lower than that of ethylnitrosourea ( enu ) -induced transformed rat schwannoma-like cells and fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
139,
150
]
} |
by autoradiography of the cultured system , we were able to visualize the accumulation of [ 3h ] 2-dg grains in the schwannoma-like cells and fibroblasts , but not in schwann cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
142,
153
]
} |
we conclude that the expression of galanin in the anterior pituitary is regulated by estrogen and suggest that galanin may be a pituitary hormone . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
50,
68
]
} | {
"id": "C0032015",
"name": "pituitary hormone",
"pos": [
128,
145
]
} |
co-existence of neuropeptides and differential inhibition of vasodilator responses by neuropeptide y in guinea pig uterine arteries . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
16,
29
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
86,
100
]
} |
using a postal questionnaire , a random sample of 1000 general practitioners throughout new zealand were surveyed about their contacts with patients concerning aids or hiv infection and about their needs for information on aids related matters . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
168,
181
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
223,
227
]
} |
the interactive effect of smoking , cholesterol , and carotene on birth weight was significant ( p = .017 ) after adjusting for gestational age , sex , prenatal care , race , previous low birth weight infants , parity , weight at mid-pregnancy , and total weight gain during pregnancy . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
66,
78
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
256,
262
]
} |
the somatomedin c levels of infants with fetal alcohol effects ( mean +/- sd 4.6 +/- 1.5 nmol/l ) were lower ( p less than .005 ) than the levels of healthy infants of drinking ( 6.8 +/- 4.0 nmol/l ) or abstinent ( 7.1 +/- 3.3 nmol/l ) mothers , but the levels did not correlate with infant birth weight , placental weight , or fetal gh or maternal somatomedin c levels . | NA | {
"id": "C0005612",
"name": "infant birth weight",
"pos": [
284,
303
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
316,
322
]
} |
the importance is stressed of early and correct antenatal diagnosis of a renal tumor and precise estimation of urine production for postnatal management of hemodynamic change in cases of mesoblastic nephroma . | NA | {
"id": "C0022665",
"name": "renal tumor",
"pos": [
73,
84
]
} | {
"id": "C0206628",
"name": "mesoblastic nephroma",
"pos": [
187,
207
]
} |
the localization and distribution of neuropeptides in the nervous system of the liver fluke , fasciola hepatica at different stages in the development of the adult fluke have been determined by an indirect immunofluorescence technique , using antisera to 19 vertebrate peptides and the invertebrate neuropeptide , fmrfamide . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
37,
49
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
314,
323
]
} |
the in vivo activity of two cyclosporins , cyclosporin a ( csa ) and a non-immunosuppressive derivative of dihydrocylosporin a ( dhcsa-d ) against three tapeworms , hymenolepis microstoma , h. diminuta and mesocestoides corti , has been assessed . | NA | {
"id": "C0010594",
"name": "cyclosporins",
"pos": [
28,
40
]
} | {
"id": "C0010592",
"name": "cyclosporin a",
"pos": [
43,
56
]
} |
in xenograft valves the smallest discrete deposits of calcification were spherical and usually associated with membranous debris of porcine donor fibroblasts , but allografts did not contain donor cell remnants and early calcification was linearly arranged along collagen fibres . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
146,
157
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
197,
201
]
} |
to estimate adrenal function , excretion of 17-ketosteroids , corticoids and their fractions with urine was investigated . | NA | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
44,
59
]
} | {
"id": "C0001617",
"name": "corticoids",
"pos": [
62,
72
]
} |
an analysis of published nucleotide sequences of the 5'-untranslated region ( 5'-utr ) of 7 cardioviruses and 3 aphthoviruses has allowed us to derive a consensus secondary structure model that differs from that previously proposed for the 5'-utr of entero- and rhinoviruses , though all these viruses belong to the same family , picornaviridae . | NA | {
"id": "C0600493",
"name": "5",
"pos": [
53,
54
]
} | {
"id": "C0600680",
"name": "utr",
"pos": [
243,
246
]
} |
over at least a 20-fold concentration range of microinjected dna , injection of equal masses of dna resulted in greater incorporation into the smaller form i dna present in molar excess . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
5,
6
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
158,
161
]
} |
solubility behavior of narcotic analgesics in aqueous media : solubilities and dissociation constants of morphine , fentanyl , and sufentanil . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
116,
124
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
131,
141
]
} |
the ph dependence of the aqueous solubility of morphine , fentanyl , and sufentanil was investigated at 35 degrees c . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
58,
66
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
73,
83
]
} |
further , at low ph 's the aqueous solubility of morphine increased in a linear fashion with increases in the molar strength of citric acid which was added to acidify the medium , suggesting the formation of a soluble morphine-citrate complex . | NA | {
"id": "C0055819",
"name": "citric acid",
"pos": [
128,
139
]
} | {
"id": "C0008857",
"name": "citrate",
"pos": [
227,
234
]
} |
pretreatment with tilorone hydrochloride ( 50 mg/kg ) 48 hr prior to the administration of procainamide hydrochloride ( 50 mg/kg ) resulted in a 32 % increase in the urinary recovery of n-acetylprocainamide and a 35 % increase in the metabolic clearance of procainamide to n-acetylprocainamide . | NA | {
"id": "C0600311",
"name": "procainamide",
"pos": [
91,
103
]
} | {
"id": "C0033216",
"name": "procainamide",
"pos": [
281,
293
]
} |
maternal serum human chorionic gonadotropin ( hcg ) and the free alpha-hcg subunit were evaluated in 249 women from 9 to 11 weeks gestation who subsequently underwent chorionic villus sampling for determination of fetal karyotype and in 20 women of 18 or more weeks gestation who were ascertained to have an aneuploid fetus by genetic amniocentesis . | NA | {
"id": "C0017963",
"name": "alpha",
"pos": [
65,
70
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
71,
74
]
} |
seven of the first-trimester pregnancies were determined to be aneuploid and six had hcg levels in the normal range ( one triploid pregnancy had elevated hcg levels ) whereas 12 of the 20 second-trimester cases had abnormal hcg levels and an additional three had elevated levels of alpha-hcg . | NA | {
"id": "C0032979",
"name": "first-trimester pregnancies",
"pos": [
13,
40
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
131,
140
]
} |
seven of the first-trimester pregnancies were determined to be aneuploid and six had hcg levels in the normal range ( one triploid pregnancy had elevated hcg levels ) whereas 12 of the 20 second-trimester cases had abnormal hcg levels and an additional three had elevated levels of alpha-hcg . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
131,
140
]
} | {
"id": "C0032980",
"name": "second-trimester",
"pos": [
188,
204
]
} |
foods rich in lignin had relatively lower fer , dmd and tpd whereas cellulose and pectin rich foods had higher dmd and tpd . | NA | {
"id": "C0023705",
"name": "lignin",
"pos": [
14,
20
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
68,
77
]
} |
repeated investigation of the same population in 3 years has shown that a decrease in the caloric content of the daily ration at the expense of fats and carbohydrates , especially starch and refined sugars , causes a decrease in the level of basal insulin , mean values of glycemia during a gtt , and atherogenic fractions of the lipid spectrum . | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
144,
148
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
330,
335
]
} |
for this purpose , four groups of rats were fed on different diets comprising 5 % of different types of lipids : fish oil , evening primose oil , hydrogenated beef tallow , and a mixture of fish oil and evening primose oil . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
104,
110
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
219,
222
]
} |
for this purpose , four groups of rats were fed on different diets comprising 5 % of different types of lipids : fish oil , evening primose oil , hydrogenated beef tallow , and a mixture of fish oil and evening primose oil . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
113,
121
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
219,
222
]
} |
for further evaluation of allopurinol , its effect was studied in two forms of fatal necrotizing acute experimental pancreatitis : sodium taurocholate-induced pancreatitis in rats and choline-deficient ethionine-supplemented diet-induced pancreatitis in mice . | NA | {
"id": "C0267941",
"name": "necrotizing acute",
"pos": [
85,
102
]
} | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
238,
250
]
} |
bioassay of plasma cholecystokinin in rat and human : inhibition of protein synthesis prevents the decrease in the sensitivity and responsiveness of isolated rat pancreatic acini to cck-8 . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
19,
34
]
} | {
"id": "C0037167",
"name": "cck-8",
"pos": [
182,
187
]
} |
under the conditions of this study , which reproduce those of excessive alcohol drinking , alcohol and alcoholic beverages did not stimulate pancreatic enzyme secretion , although wine and beer increased the release of gastrin and cholecystokinin . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
72,
79
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
180,
184
]
} |
under the conditions of this study , which reproduce those of excessive alcohol drinking , alcohol and alcoholic beverages did not stimulate pancreatic enzyme secretion , although wine and beer increased the release of gastrin and cholecystokinin . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
72,
79
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
189,
193
]
} |
in clinical practice it can be difficult to achieve complete correction of malabsorption and elimination of steatorrhea . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
75,
88
]
} | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
108,
119
]
} |
some adenomas , especially growth hormone ( gh ) , and prolactin ( prl ) cell adenomas , however , had agnor readings in the range of nontumorous cells . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
5,
13
]
} | {
"id": "C0033375",
"name": "prolactin",
"pos": [
55,
64
]
} |
fifty-nine of the 107 tumors ( 55 % ) including 32 ( 50 % ) of the 64 adenocarcinomas and 19 ( 59 % ) of the 31 adenoid cystic carcinomas arose from the surface mucosa . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
70,
85
]
} | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
112,
137
]
} |
within the iapp domains , the n-terminal and c-terminal amino acid sequences are very highly conserved among the mammals , as is also the case with a structurally related neuropeptide , calcitonin-gene-related peptide ( cgrp ) , suggesting that iapp and cgrp interact with similar though not identical receptors . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
171,
183
]
} | {
"id": "C0006669",
"name": "cgrp",
"pos": [
254,
258
]
} |
the function of this lrp was studied in mutant human fibroblasts that do not produce ldl receptors . | NA | {
"id": "C0065059",
"name": "lrp",
"pos": [
21,
24
]
} | {
"id": "C0034821",
"name": "ldl receptors",
"pos": [
85,
98
]
} |
stimulation of cholesterol esterification was blocked by the antibody against lrp , but not by an antibody against the ldl receptor . | NA | {
"id": "C0065059",
"name": "lrp",
"pos": [
78,
81
]
} | {
"id": "C0034821",
"name": "ldl receptor",
"pos": [
119,
131
]
} |
unlike the ldl receptor , the amount of lrp was not reduced when cells were incubated with oxygenated sterols . | NA | {
"id": "C0034821",
"name": "ldl",
"pos": [
11,
14
]
} | {
"id": "C0065059",
"name": "lrp",
"pos": [
40,
43
]
} |
these rheumatoid factors share a cross-reactive idiotype ( cri ) defined by reactivity with g6 , a murine monoclonal antibody that recognizes an antibody heavy chain determinant present on many human igm autoantibodies , particularly rheumatoid factors . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
204,
218
]
} | {
"id": "C0035448",
"name": "rheumatoid factors",
"pos": [
234,
252
]
} |
il-6 alone had no influence on megakaryocytic colony formation but augmented the numbers of these colonies induced by the multipotent colony-stimulating factor interleukin 3 . | NA | {
"id": "C0021760",
"name": "il-6",
"pos": [
0,
4
]
} | {
"id": "C0021764",
"name": "interleukin",
"pos": [
160,
171
]
} |
in this study , the growth stimulatory properties of the sensory neuropeptides vasoactive intestinal polypeptide ( vip ) , substance p ( sp ) , calcitonin generelated peptide ( cgrp ) , and somatostatin ( som ) on cultured human keratinocytes were investigated . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
65,
78
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
144,
154
]
} |
they are not only eluted specifically , together with snrnp particles , from anti-2,2,7-trimethylguanosine immunoaffinity columns by 7-methylguanosine , they also cofractionate with u5 snrnp during chromatography and , most importantly , in glycerol gradient centrifugation . | NA | {
"id": "C0142661",
"name": "snrnp particles",
"pos": [
54,
69
]
} | {
"id": "C0147543",
"name": "u5 snrnp",
"pos": [
182,
190
]
} |
the existence of so many unique proteins in the u5 snrnp suggests that this snrnp particle may exert its function during splicing mainly by virtue of its protein components . | NA | {
"id": "C0147543",
"name": "u5",
"pos": [
48,
50
]
} | {
"id": "C0142661",
"name": "snrnp particle",
"pos": [
76,
90
]
} |
using the rna/lipofectin transfection procedure , we have analyzed the role of capping and beta-globin 5 ' and 3 ' untranslated sequences on the translation efficiency of luciferase rna synthesized in vitro . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
10,
13
]
} | {
"id": "C0887909",
"name": "untranslated",
"pos": [
115,
127
]
} |
adp-ribosylation factors ( arfs ) are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin . | NA | {
"id": "C0101671",
"name": "adp-ribosylation factors",
"pos": [
0,
24
]
} | {
"id": "C0751984",
"name": "small guanine nucleotide-binding proteins",
"pos": [
38,
79
]
} |
the observations reported here support the conclusion that the arfs are members of a multigene family of small guanine nucleotide-binding proteins . | NA | {
"id": "C0101671",
"name": "arfs",
"pos": [
63,
67
]
} | {
"id": "C0751984",
"name": "small guanine nucleotide-binding proteins",
"pos": [
105,
146
]
} |
generation of dictyostelium cells lacking myosin i by gene disruption and/or antisense rna production should provide a way to test directly the role of this nonfilamentous myosin in cell motility . | NA | {
"id": "C0086669",
"name": "myosin i",
"pos": [
42,
50
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
172,
178
]
} |
experiments were carried out in the skin of patients with leprosy to examine whether suppressor cell populations either exist in the skin of multibacillary lepromatous leprosy patients , can be activated with antigen , or are induced to emigrate into a cutaneous site from the circulation . | NA | {
"id": "C0023343",
"name": "leprosy",
"pos": [
58,
65
]
} | {
"id": "C1562585",
"name": "multibacillary",
"pos": [
141,
155
]
} |
the products exhibited the antigenic and immunogenic characteristics of both the hepatitis b core antigen epitopes and the epitopes carried by the additional sequences , thus illustrating the value of such proteins as immunological reagents and potential vaccines . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
27,
36
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
123,
131
]
} |
v beta 9-expressing t cells are clonally deleted from the periphery of mice that carry the mls-1a allele , and the fine specificity of v beta 9+ hybridomas suggests that v beta 6- , v beta 8.1- , and v beta 9-encoded t-cell receptors may recognize a similar antigenic epitope . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
258,
267
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
268,
275
]
} |
recent studies suggest that keratinocyte proliferation and inflammation in psoriasis are manifestations of the same underlying pathological process . | NA | {
"id": "C0021368",
"name": "inflammation",
"pos": [
59,
71
]
} | {
"id": "C0030660",
"name": "pathological process",
"pos": [
127,
147
]
} |
employing the mu-selective opioid agonist [ d-ala2 , mephe4 , gly-ol5 ] enkephalin ( damgo ) in direct binding studies and in competition of labeled antagonist binding , we found that the major changes were a decrease in the number of sites with high affinity for agonist , a small reduction in total receptor number , and a loss in the ability of guanosine 5'- [ gamma-thio ] triphosphate to regulate binding . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
72,
82
]
} | {
"id": "C0525773",
"name": "damgo",
"pos": [
85,
90
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.