text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
an apparent involvement of dopamine in the regulation of cognitive functions and the recognition of a widespread dopaminergic innervation of the cortex have focused attention on the identity of cortical dopamine receptors . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
27,
35
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
113,
125
]
} |
the drash syndrome ( nephrotic syndrome , male pseudohermaphroditism and wilms ' tumor ) has interesting connections with this group . | NA | {
"id": "C0950121",
"name": "drash syndrome",
"pos": [
4,
18
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
73,
78
]
} |
niosomes appear physically stable while hemoglobin undergoes a progressive oxidation to methemoglobin reaching 30 % after 5 months at 4 degrees c . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
40,
50
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
88,
101
]
} |
mucosal explants and sheets of epithelial cells isolated from rabbit small and large intestine were exposed to leukotrienes b4 , c4 , and d4 and monohydroxyeicosatetraenoic acids 5-hete , 12-hete , and 15-hete . | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
181,
185
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
188,
195
]
} |
limited trypsinization of large pea ( pisum sativum cv . alaska ) phytochrome and subsequent size-exclusion chromatography ( sec ) in 0.1 m na phosphate , ph 7.8 , yielded a high-molecular-mass aggregate of tryptic fragments of phytochrome . | NA | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
66,
77
]
} | {
"id": "C0250581",
"name": "a",
"pos": [
217,
218
]
} |
a comparison with other furocoumarins 4,4'-dimethylangelicin ( 4,4'-dma ) , 4'-methylangelicin ( 4'-ma ) , angelicin , 4,5',8-trimethylpsoralen ( tmp ) and 8-methoxypsoralen ( 8-mop ) is also reported . | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
24,
37
]
} | {
"id": "C0025684",
"name": "8-methoxypsoralen",
"pos": [
156,
173
]
} |
protein intersubunit crosslinking , change in charge of the protein subunits to more acidic species and changes in protein tertiary structure ( conformation ) by 300 nm irradiation are reported . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
60,
76
]
} |
it was found that 1.1 % of women had bulimia nervosa and 2.8 % a partial-syndrome eating disorder . | NA | {
"id": "C2267227",
"name": "bulimia nervosa",
"pos": [
37,
52
]
} | {
"id": "C0013473",
"name": "eating disorder",
"pos": [
82,
97
]
} |
measures of headache pain ( frequency , intensity ) , skin temperature , and assessment with the millon behavioral health inventory consisting of broad categories and scales were taken at pretest , posttest and follow-up . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
12,
20
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
21,
25
]
} |
the personality diagnostic questionnaire ( pdq ) was completed by 628 eating-disordered women : 300 with normal-weight bulimia , 15 with anorexia nervosa with bulimic features , and 313 with subdiagnostic eating disorders . | NA | {
"id": "C0003125",
"name": "anorexia",
"pos": [
137,
145
]
} | {
"id": "C0013473",
"name": "eating disorders",
"pos": [
205,
221
]
} |
this review describes the appearance of the most frequently occurring facial dyskinesias : chorea , dystonia , tremor , and tics . | NA | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
77,
88
]
} | {
"id": "C0008489",
"name": "chorea",
"pos": [
91,
97
]
} |
this review describes the appearance of the most frequently occurring facial dyskinesias : chorea , dystonia , tremor , and tics . | NA | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
77,
88
]
} | {
"id": "C0040822",
"name": "tremor",
"pos": [
111,
117
]
} |
slices from fibrotic livers incorporated more 14c-proline and produced more 14c-hydroxyproline in tca precipitable proteins than slices from control livers . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
50,
57
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
80,
94
]
} |
the magnitude of the dmpg induced decrease in labeled proline incorporation correlated with the hydroxyproline content in the liver ( i.e . with increasing fibrosis there was a greater effect of dmpg : while in control rat liver slices , dmpg had no effect ) . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
54,
61
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
96,
110
]
} |
these findings indicate that the presence of a third double bond in the prostaglandin f molecule between carbons 17 and 18 markedly reduces the protective effects of this prostaglandin on the gastric mucosa . | NA | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
72,
87
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
171,
184
]
} |
a description is given of the different types of grafts : venous , arterial , skin and conjunctiva , as well as prostheses of plastic material , polyvinyl , silicon , used in the reparatory and reconstructive surgery of the lacrimal ducts . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
126,
133
]
} | {
"id": "C0032629",
"name": "polyvinyl",
"pos": [
145,
154
]
} |
although the patient presented moderate grade pancreatic failure , there is presently no agreement as to whether pancreatitis secondary to cystic fibrosis can be considered as chronic pancreatitis . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
113,
125
]
} | {
"id": "C0149521",
"name": "chronic pancreatitis",
"pos": [
176,
196
]
} |
this anion competitively inhibits thyroid iodide transport , reducing intrathyroidal iodide content and removing thyroid hormone synthesis inhibition . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
5,
10
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
85,
91
]
} |
recently new tests have been proposed which employ monoclonal antibodies interacting specifically with antigenic sites of cross-linked fibrin and its degradation products , making it possible to distinguish these degradation products from those of fibrinogen and to have a more precise evaluation of fibrinolysis . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
135,
141
]
} | {
"id": "C0163275",
"name": "degradation products",
"pos": [
213,
233
]
} |
furthermore , they are used to inhibit bone resorption , especially in diseases such as paget 's disease and tumoral osteolysis . | NA | {
"id": "C0005974",
"name": "bone resorption",
"pos": [
39,
54
]
} | {
"id": "C0221204",
"name": "osteolysis",
"pos": [
117,
127
]
} |
when incubated in isosmotic oxygenated medium in which chloride was completely replaced by gluconate , rabbit renal cortical slices lost chloride with sodium , potassium and water before reaching a new steady-state composition after 15-30 min . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
55,
63
]
} | {
"id": "C0037494",
"name": "chloride",
"pos": [
137,
145
]
} |
again , the combined loss of diffusible inorganic cations exceeded the loss of chloride but the water loss was that expected for isosmotic loss accompanying the measured losses of ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
50,
57
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
180,
184
]
} |
retained hydrogen ions are buffered on charged cellular non-diffusible solutes and the associated hydroxyl ( or bicarbonate ) ions are lost from the cells accompanied by the inorganic univalent cations lost in excess of chloride in nmdg+ medium . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
18,
22
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
194,
201
]
} |
we studied the effect of bleed rate on survival time and hemodynamics in a continuous hemorrhage model of fatal hemorrhagic shock in lightly anesthetized swine . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
86,
96
]
} | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
112,
129
]
} |
2 ) about twice as many patients achieved an important loss of weight in terms of percentage of the initial weight or overweight ; | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
63,
69
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
118,
128
]
} |
the sporozoite protein of plasmodium falciparum has 37-41 repeats of four amino acids : nanp ( asparagine-alanine-asparagine-proline ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
74,
85
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
106,
113
]
} |
diseases for which vaccines are not likely to be available in the next decade include trachoma , onchocerciasis , pneumonia due to legionella and to mycoplasmas , amebiasis and giardiasis , schistosomiasis , syphilis , chlamydial urethritis , trypanosomiasis , leishmaniasis , and filariasis , and non-a , non-b hepatitis . | NA | {
"id": "C0029001",
"name": "onchocerciasis",
"pos": [
97,
111
]
} | {
"id": "C0016085",
"name": "filariasis",
"pos": [
281,
291
]
} |
the method can detect hbeag in immune complexes whether antigen or antibody is in excess . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
31,
47
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
67,
75
]
} |
the most striking effect of 1 % dietary cholesterol on acat activity was obtained in the control group ( 34 % enhancement ) , whereas cholesterol supplementation had no effect on acat activity in the salmon oil group . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
32,
51
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
134,
145
]
} |
comparison of interleukin 1 release and interleukin 1 mrna expression of human monocytes activated by bacterial lipopolysaccharide or synthetic lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
112,
130
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
144,
151
]
} |
several of the biological effects of bacterial lipopolysaccharide ( lps ) can be induced by the lipid a part of the molecule . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
47,
65
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
96,
103
]
} |
here we show that in human peripheral blood monocytes , synthetic e. coli lipid a is as effective as the whole lps molecule in inducing the production of interleukin 1 ( il-1 ) bioactivity which remains associated to the cells ( i.e . il-1 alpha ) . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
74,
81
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
111,
114
]
} |
in contrast , lps- but not lipid a-stimulated cells released the bioactive il-1 produced into the culture supernatant ( mainly il-1 beta ) . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
14,
17
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
27,
34
]
} |
northern blotting analysis demonstrated , however , that lps and lipid a are equally effective in inducing the accumulation of il-1 alpha and il-1 beta mrna . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
57,
60
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
65,
72
]
} |
the first can be provided by specific monoclonal antibodies or by mitogenic lectins , and the second by a phorbol ester , phorbol myristate acetate ( pma ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
106,
119
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
122,
147
]
} |
moreover , none of the antibodies tested ( anti-cd3 , anti-cd2 , and anti-cd28 ) and known to activate t cells , and none of the immune complexes was able to mediate such an effect . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
23,
33
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
129,
145
]
} |
several solutions are under development , including fusion techniques that enrich for cells producing desired antibodies , production of human-mouse chimeric antibodies by recombinant dna technology , and the generation of human monoclonal antibodies by promising new approaches . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
110,
120
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
229,
250
]
} |
antibodies , specifically monoclonal antibodies , are potentially very useful and powerful carriers of therapeutic agents to target tissues and diagnostic agents . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
26,
47
]
} |
two major groups of moabs have been tested : antibodies directed against platelets and antibodies directed against fibrin . | NA | {
"id": "C0003250",
"name": "moabs",
"pos": [
20,
25
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
87,
97
]
} |
several antiplatelet antibodies have been developed that are directed against either the platelet membrane glycoprotein complex , iib/iiia , which binds fibrinogen , or against two different proteins , alpha granule membrane protein gmp-140 and thrombospondin ( tsp ) that are expressed during platelet activation . | NA | {
"id": "C0032195",
"name": "platelet membrane glycoprotein",
"pos": [
89,
119
]
} | {
"id": "C0134835",
"name": "gmp-140",
"pos": [
233,
240
]
} |
12 ( 75 % ) had cardiographic evidence of left ventricular hypertrophy , ten ( 63 % ) had radiologic evidence of cardiomegaly , and ten ( 63 % ) had clinical signs of hypertensive retinopathy . | NA | {
"id": "C0149721",
"name": "left ventricular",
"pos": [
42,
58
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
113,
125
]
} |
during the three-year follow-up period , seven had clinical lacunar stroke syndrome , three had cortical stroke , two had myocardial infarction , and one died suddenly of unknown cause . | NA | {
"id": "C3178801",
"name": "lacunar stroke syndrome",
"pos": [
60,
83
]
} | {
"id": "C0038454",
"name": "stroke",
"pos": [
105,
111
]
} |
monoclonal antibodies ( mabs ) directed against gram-negative bacterial lipopolysaccharide ( endotoxin , lps ) are currently being evaluated as an adjunctive form of therapy for lethal gram-negative bacterial sepsis and shock . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
93,
102
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
105,
108
]
} |
by developing a panel of mabs that bound to various regions of the lps molecule ( o saccharide ; outer , intermediate , and inner core ; lipid a ) , we were able to determine that some epitopes in the inner core/lipid a region of lps were broadly shared among different genera of gram-negative microorganisms , on the basis of immunoblot analysis of mab binding to lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
137,
144
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
365,
368
]
} |
the effects of daily administration of marine oil -- delivering 100 mg of eicosapentaenoic acid , 59 mg of docosahexaenoic acid , and 221 mg of omega-3 fatty acids per kilogram -- were assessed in 33 new zealand white rabbits . | NA | {
"id": "C0012968",
"name": "docosahexaenoic acid",
"pos": [
107,
127
]
} | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
144,
163
]
} |
half of each treatment group was given plain water and the rest indo-treated ( 14 micrograms/cc ) drinking water throughout the duration of the experiment . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
45,
50
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
98,
112
]
} |
these results suggest that endotoxin-induced bacterial translocation requires the presence of the terminal core lipopolysaccharide moiety and that xanthine oxidase-generated oxidants are important in the pathogenesis of endotoxin-induced mucosal injury and bacterial translocation . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
112,
130
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
220,
229
]
} |
tumor necrosis factor ( tnf ) is reported to cause a shock syndrome similar to that produced by endotoxin ( lps ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
96,
105
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
108,
111
]
} |
the authors describe 6 cases of acute leukemia in which erythroid antigens identified by monoclonal antibodies hae-3 and hae-9 ( against glycophorin a and antigen of nuclear erythroid cells ) were expressed on blasts . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
66,
74
]
} | {
"id": "C0069115",
"name": "antigen",
"pos": [
155,
162
]
} |
a total of 136 patients with trans- and 200 with non-transmural myocardial infarction ( mi ) were examined over time for chlorine-soluble mucoprotein ( mp ) , serum hexoses ( sh ) , their fraction-hexoses of glycosaminoglycans ( h-gag ) , and hexoses of glycoproteins ( h-gp ) , serum , plasma and urine hydroxyproline ( shp , php , uhp ) . | NA | {
"id": "C0026714",
"name": "mucoprotein",
"pos": [
138,
149
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
254,
267
]
} |
the levels of anaphylatoxins ( c3a , c5a ) in blood , components of complements c3 and c4 , antibodies to cardiolipin , igg , iga , igm , ige and circulating immune complexes were measured in 21 patients with dilated and hypertrophic cardiomyopathy ( dcmp and hcmp ) and in 11 donors . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
14,
28
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
31,
34
]
} |
activated carbon is made in sri lanka by passing steam through charcoal made from coconut shells . | NA | {
"id": "C0001275",
"name": "activated carbon",
"pos": [
0,
16
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
63,
71
]
} |
there was no evidence that people exposed to charcoal and pure carbon for up to 11 years are at risk of developing pneumoconiosis . | NA | {
"id": "C0007955",
"name": "charcoal",
"pos": [
45,
53
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
63,
69
]
} |
pf4 affinity for gags is as follows : heparin greater than heparan sulphate much greater than dermatan sulphate . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
17,
21
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
38,
45
]
} |
pf4 affinity for gags is as follows : heparin greater than heparan sulphate much greater than dermatan sulphate . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
17,
21
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
59,
75
]
} |
in this study the in vitro effects of isradipine , a new dihydropyridine-derivative , and of nifedipine on platelet aggregation and malondialdehyde-production were tested . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
38,
48
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
57,
72
]
} |
in this study the in vitro effects of isradipine , a new dihydropyridine-derivative , and of nifedipine on platelet aggregation and malondialdehyde-production were tested . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
57,
72
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
93,
103
]
} |
in addition to these results the solid-phase synthesis of peptide alcohols via direct displacement of p-nitrobenzhydrylideneisonitroso resin attached peptides with the desired c-terminal amino alcohol is reported . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
66,
74
]
} | {
"id": "C0002530",
"name": "amino alcohol",
"pos": [
187,
200
]
} |
since plasma catecholamines , adrenaline and noradrenaline were increased in smokers ( 3.95 +/- 0.7 vs 2.26 +/- 0.1 pmol/ml , p less than 0.05 ) at rest , the objective of an acute additional adrenergic discharge by physical exercise was to uncover possible tachyphylaxis . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
30,
40
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
45,
58
]
} |
pleural effusions refer to many different conditions of the pleura itself or to generalized diseases . | NA | {
"id": "C0032227",
"name": "pleural effusions",
"pos": [
0,
17
]
} | {
"id": "C0032226",
"name": "conditions of the pleura",
"pos": [
42,
66
]
} |
it is hypothesised that although anti-blood cell antibodies may not be the primary cause of the severe anaemia and thrombocytopaenia which accompany the haemorrhagic syndrome , they could play an important role in the maintenance of these signs of disease , adversely affecting the outcome of t. vivax-associated haemorrhagic disease in the field . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
166,
174
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
326,
333
]
} |
this assay overcomes the problems of currently used tests for b. bigemina infection as it is both sensitive and specific and is able to discriminate between both field and laboratory infections of b. bigemina and b. bovis . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
74,
83
]
} | {
"id": "C0022882",
"name": "laboratory infections",
"pos": [
172,
193
]
} |
the glutathione oxidant defence system in leucocytes and erythrocytes of six anaplasma marginale-infected calves was examined by assaying glutathione peroxidase ( gsh-px ) , glutathione reductase ( gssg-r ) , reduced glutathione ( gsh ) and superoxide dismutase ( sod ) . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
198,
202
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
231,
234
]
} |
variation within sheep breeds in resistance to nematode infection is as great as that between breeds , is moderately heritable , and selection of lines of resistant sheep should result in animals carrying worm burdens around 10 % -20 % of those of unselected animals . | NA | {
"id": "C0027583",
"name": "nematode",
"pos": [
47,
55
]
} | {
"id": "C0018889",
"name": "worm",
"pos": [
205,
209
]
} |
the results lead to three conclusions : firstly , synovial sarcomas possess the capacity for generating different epithelial cell types with uncommon compositions of intermediate filaments as well as of membrane proteins , secondly , these features may be expressed in a heterogenous pattern even within the same tumour and finally , the use of wide range anti-cytokeratin antibodies covering the spectrum of basic as well as acidic type proteins seems to be necessary for the detection of all epithelial components demonstrable in synovial sarcomas . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
203,
220
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
438,
446
]
} |
bone and red blood cell dna was obtained from mav-2 ( o ) infected , osteopetrotic chickens and analyzed for the presence of integrated and unintegrated viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
24,
27
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
153,
162
]
} |
angioimmunoblastic lymphadenopathy is usually characterized as a lymphoproliferative disease caused by an abnormal reaction to various chemical and biological antigens and the possible development into malignant lymphomas of different types . | NA | {
"id": "C0020981",
"name": "angioimmunoblastic lymphadenopathy",
"pos": [
0,
34
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disease",
"pos": [
65,
92
]
} |
angioimmunoblastic lymphadenopathy is usually characterized as a lymphoproliferative disease caused by an abnormal reaction to various chemical and biological antigens and the possible development into malignant lymphomas of different types . | NA | {
"id": "C0024314",
"name": "lymphoproliferative disease",
"pos": [
65,
92
]
} | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
202,
221
]
} |
antigens reacting with anti-c3c antibodies were also detected on e from normal individuals , but the density of c3c-epitopes was 0.9-2.4 times lower than that of c3d-epitopes . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
0,
8
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
166,
174
]
} |
[ disordered interferon status in patients with urticaria and angioneurotic edema against a background of frequent arvi : its correction with reaferon ] . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
48,
57
]
} | {
"id": "C0002994",
"name": "angioneurotic edema",
"pos": [
62,
81
]
} |
the results of clinical , allergological , virological , and immunological examinations of patients with urticaria and angioneurotic edema against the background of frequent arvi are presented . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
105,
114
]
} | {
"id": "C0002994",
"name": "angioneurotic edema",
"pos": [
119,
138
]
} |
the principal possibility of using antibodies conjugated with colloid gold for better visualization of viruses , viral antigens , and their immune complexes in electron microscope was studied on the experimental model of hbs-antigen and venezuelan equine encephalomyelitis virus . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
35,
45
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
140,
156
]
} |
the principal possibility of using antibodies conjugated with colloid gold for better visualization of viruses , viral antigens , and their immune complexes in electron microscope was studied on the experimental model of hbs-antigen and venezuelan equine encephalomyelitis virus . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
113,
127
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
225,
232
]
} |
an immunoregulatory influence of lipoproteins from different density fractions-low density lipoproteins ( ldl ) , high density lipoproteins ( hdl ) and very low density lipoproteins ( vldl ) on the in vitro mitogen response of human peripheral blood lymphocytes ( pbl ) was shown . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
33,
45
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
152,
181
]
} |
testing sera from patients with acute or reactivated infections with other herpesviruses , such as cytomegalovirus ( cmv ) , epstein-barr virus ( ebv ) , herpes simplex virus ( hsv ) and varicella zoster virus ( vzv ) we observed a remarkably higher prevalence of antibodies to hhv-6 in patients with cmv infections ( 75 % ) and also in patients with ebv infections ( 50 % ) . | NA | {
"id": "C0019372",
"name": "infections",
"pos": [
53,
63
]
} | {
"id": "C0010823",
"name": "cmv infections",
"pos": [
301,
315
]
} |
testing sera from patients with acute or reactivated infections with other herpesviruses , such as cytomegalovirus ( cmv ) , epstein-barr virus ( ebv ) , herpes simplex virus ( hsv ) and varicella zoster virus ( vzv ) we observed a remarkably higher prevalence of antibodies to hhv-6 in patients with cmv infections ( 75 % ) and also in patients with ebv infections ( 50 % ) . | NA | {
"id": "C0019372",
"name": "infections",
"pos": [
53,
63
]
} | {
"id": "C0149678",
"name": "ebv infections",
"pos": [
351,
365
]
} |
this study examined the pharmacokinetics of the enantiomers of mexiletine in five healthy subjects who were each given a single , 300 mg , oral dose of racemic mexiletine hydrochloride . | NA | {
"id": "C0025887",
"name": "mexiletine",
"pos": [
63,
73
]
} | {
"id": "C0543459",
"name": "mexiletine hydrochloride",
"pos": [
160,
184
]
} |
the basic triad of symptoms that occurs in the tma syndrome include microangiopathic hemolytic anemia , thrombocytopenia , and renal impairment . | NA | {
"id": "C2717961",
"name": "tma",
"pos": [
47,
50
]
} | {
"id": "C0040034",
"name": "thrombocytopenia",
"pos": [
104,
120
]
} |
prescribing of long half-life benzodiazepines , such as diazepam ( p less than 0.01 ) and chlordiazepoxide , clorazepate , halazepam , and prazepam as a group ( p less than 0.01 ) decreased as well as the use of nearly all products containing barbiturates ( p less than 0.01 ) . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
30,
45
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
90,
106
]
} |
triglyceride concentrations increased within two min in lipoprotein fractions d less than 0.95 g/ml ( chylomicrons ) , d less than 1.006 g/ml ( vldl ) , d less than 1.063 g/ml ( ldl ) and d less than 1.21 g/ml ( hdl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
56,
67
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
102,
114
]
} |
thus in contrast to lct , mct are only found in triglyceride-rich lipoproteins ( d less than 1.006 ) and are also eliminated more rapidly . | NA | {
"id": "C0041004",
"name": "lct",
"pos": [
20,
23
]
} | {
"id": "C0724624",
"name": "mct",
"pos": [
26,
29
]
} |
lactoferrin is a symmetrically constructed glycoprotein which appears in the milk and in the body fluids and develops a bacteriostatic efficiency on account of the ability to fe-binding together with other factors such as the iga . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
0,
11
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
43,
55
]
} |
aside from the specific skin diseases , such as erythema nodosum or pyoderma gangraenosum , a number of unspecific skin eruptions may be found in both disorders . | NA | {
"id": "C0037274",
"name": "skin diseases",
"pos": [
24,
37
]
} | {
"id": "C0034212",
"name": "pyoderma",
"pos": [
68,
76
]
} |
aside from the specific skin diseases , such as erythema nodosum or pyoderma gangraenosum , a number of unspecific skin eruptions may be found in both disorders . | NA | {
"id": "C0037274",
"name": "skin diseases",
"pos": [
24,
37
]
} | {
"id": "C0015230",
"name": "of",
"pos": [
101,
103
]
} |
[ atopic dermatitis . ii . the status of complement proteins and the pathogenetic role of anaphylatoxins c4a , c3a and c5a ] . | NA | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
41,
60
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
90,
104
]
} |
[ atopic dermatitis . ii . the status of complement proteins and the pathogenetic role of anaphylatoxins c4a , c3a and c5a ] . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
90,
104
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
111,
114
]
} |
the level of hb f could be determined by measuring the total of chromatogram gamma-globin chain areas , and expressing it as a percentage of total hb . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
13,
17
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
147,
149
]
} |
heavy pain-syndromes in diseases which are not life-menacing can apparently be dealt with the better the more the concerned people succeed to turn the anxiety which is little related to objects in object-related fear . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
11,
20
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
24,
32
]
} |
serum levels of total cholesterol ( tc ) , hdl-cholesterol ( hdl-c ) , triglycerides ( tg ) and , 17 beta-estradiol ( e2 ) , as well as the values of ldl1-cholesterol ( ldl1-c ) , hdl-c/tc , and hdl-c/ldl1-c were determined in 72 patients with uterine leiomyoma and 45 healthy women aged 34-54 . | NA | {
"id": "C0008377",
"name": "hdl-c",
"pos": [
43,
48
]
} | {
"id": "C0023822",
"name": "hdl-c",
"pos": [
195,
200
]
} |
the values of cholesterol parameters ( ct , hdl-c ) showed a statistically significant increase in the youngest patients . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
14,
25
]
} | {
"id": "C0023822",
"name": "hdl-c",
"pos": [
44,
49
]
} |
all strains were resistant to penicillin g and ampicillin , more than 90 % to nitrofurantoin , sulfamethoxazole-trimethoprim , chloramphenicol and erythromycin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
30,
42
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
47,
57
]
} |
essential thrombocythemia ( et ) belongs to the group of clonal myeloproliferative disorders such as polycythemia vera ( pv ) , chronic myelogenous leukemia ( cml ) , and idiopathic myelofibrosis ( mf ) . | NA | {
"id": "C0027022",
"name": "myeloproliferative",
"pos": [
64,
82
]
} | {
"id": "C0001815",
"name": "idiopathic myelofibrosis",
"pos": [
171,
195
]
} |
tenascin , a novel extracellular matrix protein , was demonstrated immunohistochemically in rabbit corneas that had healed after anterior keratectomy . | NA | {
"id": "C0076088",
"name": "tenascin",
"pos": [
0,
8
]
} | {
"id": "C0079323",
"name": "extracellular matrix protein",
"pos": [
19,
47
]
} |
no significant difference was found in regard to timer elapsed since termination of radiotherapy ( more or less than 6 months ) , irradiation field extension ( limited to the larynx or extended to the neck nodes ) , type of surgical salvage ( including neck dissection or not ) and pre-operative hemoglobin and blood proteins values . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
296,
306
]
} | {
"id": "C0005832",
"name": "blood proteins",
"pos": [
311,
325
]
} |
she had a wide fluctuation of plasma dopamine from 209 pmol/l to 305 nmol/l during 12 hours of observation period , but plasma norepinephrine and epinephrine remained within the normal range as well as urinary excretion of catecholamines . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
127,
141
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
146,
157
]
} |
consistently positive anti-vca-iga- and anti-ea-iga- antibody may be a characteristic feature of abnormal antibody responses in severe chronic active ebv-infection in childhood . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
27,
30
]
} | {
"id": "C0003320",
"name": "ea",
"pos": [
87,
89
]
} |
although the dog ptc tended to overgrow the contaminating fibroblastic cells , the rat ptc tended to be overgrown by the latter cells when cultured in medium containing 15 % fetal calf serum ( fcs ) . | NA | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
58,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
} |
in addition , bone organic matrix degradation was determined either by the release of 3h from [ 3h ] proline-labeled bones or by the loss of hydroxyproline from bone explants during culture . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
101,
108
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
141,
155
]
} |
in the course of addressing these issues , attention is devoted to the outcomes as well as the advantages and disadvantages of commonly used research designs ( prospective , retrospective , and catch-up prospective ) , the level of diagnosis used ( symptom , syndrome , disorder ) , the significance of the age of onset on severity , and specific areas in need of further research . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
259,
267
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
270,
278
]
} |
the modifications concerned the composition of agar gel ( 1.8 % bacto-agar difco ) , addition of polyethylene glycol ( peg 6000 , 4 % ) and enlarging the diameters of the wells from 6 to 10 mm for sera . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
97,
116
]
} | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
119,
127
]
} |
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