text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
changes in the cell surface oligosaccharides in human fetal lung fibroblasts ( imr-90 ) are studied as the cells progress to senescence using nuclear magnetic resonance spectroscopy ( nmr ) and a biochemical assay . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
65,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} |
platelet membrane glycoprotein ( gp iib-iiia ) , besides its activity as adhesive protein receptor , displays a number of properties supporting its involvement in the mechanisms of transduction of the activation signal . | NA | {
"id": "C0032195",
"name": "platelet membrane glycoprotein",
"pos": [
0,
30
]
} | {
"id": "C0016011",
"name": "gp iib-iiia",
"pos": [
33,
44
]
} |
indirect evidence for coupling between d-imino acids and h+ fluxes was obtained by the following observations : ( 1 ) addition of the h+ ionophore ( fccp ) to the vesicle-dye ( 3,3'-diethyloxadicarbocyanine iodide ) suspension completely abolished the na+-independent electrogenic uptake of d-proline and hydroxy-d-proline by membrane vesicles from pars convoluta . | NA | {
"id": "C0020931",
"name": "imino acids",
"pos": [
41,
52
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
315,
322
]
} |
the native and modified enzymes exhibited similar inhibitory constant values with respect to nadh , suggesting no contribution of arginine residues to the acyl-enzyme.nadh complex destabilization . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
24,
31
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
160,
166
]
} |
ultraviolet absorption spectra of phospholamban reflected its aromatic amino acid content : absorption peaks at 275-277 nm and 253 , 259 , 265 and 268 nm were attributed to phospholamban 's one tyrosine and two phenylalanines , respectively . | NA | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
62,
81
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
194,
202
]
} |
ultraviolet absorption spectra of phospholamban reflected its aromatic amino acid content : absorption peaks at 275-277 nm and 253 , 259 , 265 and 268 nm were attributed to phospholamban 's one tyrosine and two phenylalanines , respectively . | NA | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
62,
81
]
} | {
"id": "C0031453",
"name": "phenylalanines",
"pos": [
211,
225
]
} |
chloroplast nadp-dependent glyceraldehyde-3-phosphate dehydrogenase retains the deuterium at the c4 ha position ( removing the hydrogen atom ) , and is therefore a b ( pro-s ) specific dehydrogenase . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
80,
89
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
187,
195
]
} |
methylation of thymine and uracil with free methyl cations formed due to beta-decay of tritiated methane : possible implication in mutagenesis and carcinogenesis . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
15,
22
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
27,
33
]
} |
exposure of solid thymine and uracil at room temperature to free methyl cations , produced due to beta-decay of tritiated methane , resulted in formation of their 1- , o2- , 3- , o4- , and 6-methyl derivatives . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
18,
25
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
30,
36
]
} |
use of 1-ethyl-3- ( 3-dimethylaminopropyl ) carbodiimide to introduce rna-protein crosslinks in the 40s and 60s subunits of the cytoplasmic ribosome of tetrahymena thermophila is described , and proteins linked covalently to 17s and 26s ribosomal rnas are identified . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
70,
73
]
} | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
237,
251
]
} |
the results indicate that ghb is efficacious for reducing the frequency of cataplexy attacks and subjective nocturnal arousals in patients with narcolepsy within the first 4 weeks of treatment . | NA | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
75,
84
]
} | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
144,
154
]
} |
these results suggest that a heparin-like glycosaminoglycan from the oviduct is a potential in vivo capacitating agent in the bovine . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
29,
36
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
42,
59
]
} |
this study investigated the direct effect of catecholamines , epinephrine ( epi ) , and norepinephrine ( ne ) on basal and gonadotropin-releasing hormone ( gnrh ) -stimulated secretion of luteinizing hormone ( lh ) from dispersed pig pituitary cells in vitro . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
62,
73
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
88,
102
]
} |
the degree of this reduction was dependent on epi and ne , and a concentration of epi and ne higher than 1 ng/ml and 100 ng/ml , respectively , was needed . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
46,
49
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
148,
150
]
} |
in striking contrast to the maintenance of hypothalamic gnrh content throughout postnatal development , pituitary gonadotropin contents and serum gonadotropin concentrations were markedly reduced in juvenile monkeys . | NA | {
"id": "C0018061",
"name": "gnrh",
"pos": [
56,
60
]
} | {
"id": "C0018066",
"name": "pituitary gonadotropin",
"pos": [
104,
126
]
} |
in the large diameter channels , where bulk electrolyte may be assumed to enter the pore , the electrolyte greatly reduces the image barrier to ion permeation . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
44,
55
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
155,
158
]
} |
we report here that interleukin-4 ( il-4 ) ( 0.1 to 0.25 u/ml ; 1 to 3 x 10 ( -11 ) mol/l ) , but not interferon-gamma ( ifn-gamma ) , elevates t-pa messenger ( m ) rna expression and secretion of t-pa activity by human monocytes , with the maximum response at 2.5 u/ml . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
144,
148
]
} | {
"id": "C0032144",
"name": "t-pa",
"pos": [
197,
201
]
} |
increased circulating csf-1 ( m-csf ) in myeloproliferative disease : association with myeloid metaplasia and peripheral bone marrow extension . | NA | {
"id": "C0027022",
"name": "myeloproliferative disease",
"pos": [
41,
67
]
} | {
"id": "C0001815",
"name": "myeloid metaplasia",
"pos": [
87,
105
]
} |
in view of the known cooperativity between csf-1 and other growth factors in regulating hematopoiesis , the finding of increased serum csf-1 concentrations and its association with myeloid metaplasia and bone marrow extension may indicate a pathophysiologic role for csf-1 in determining the phenotypic expression of mpd . | NA | {
"id": "C0001815",
"name": "myeloid",
"pos": [
181,
188
]
} | {
"id": "C0027022",
"name": "mpd",
"pos": [
317,
320
]
} |
the recombinant plasmid ( bmgneo-gcsf ) was transfected into nih/3t3 fibroblasts by the calcium phosphate coprecipitation method , and the stably transformed cells were isolated by g418 selection . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
69,
80
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
pma also induces secretion of the two inhibitors of plasminogen activator : plasminogen activator inhibitor 1 ( pai-1 ) and plasminogen activator inhibitor 2 ( pai-2 ) . | NA | {
"id": "C0032145",
"name": "inhibitors",
"pos": [
38,
48
]
} | {
"id": "C0030190",
"name": "plasminogen activator inhibitor 1",
"pos": [
76,
109
]
} |
pma also induces secretion of the two inhibitors of plasminogen activator : plasminogen activator inhibitor 1 ( pai-1 ) and plasminogen activator inhibitor 2 ( pai-2 ) . | NA | {
"id": "C0032145",
"name": "inhibitors",
"pos": [
38,
48
]
} | {
"id": "C0030191",
"name": "plasminogen",
"pos": [
124,
135
]
} |
the receptors for fibronectin ( fn-r ) and vitronectin ( vn-r ) belong to a family of integral membrane glycoproteins known to be involved in cell-extracellular matrix and cell-cell interactions named integrins ( fn-r = beta 1 integrin and vn-r = beta 3 integrin ) . | NA | {
"id": "C0060377",
"name": "receptors",
"pos": [
4,
13
]
} | {
"id": "C0021701",
"name": "integrins",
"pos": [
201,
210
]
} |
the distribution of beta 1 and beta 3 integrin complexes on pbmcs was characterized by immunoprecipitation of detergent extracts of 125i-labeled cells using polyclonal antibodies against these two receptors . | NA | {
"id": "C1321301",
"name": "pbmcs",
"pos": [
60,
65
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
145,
150
]
} |
human hematopoietic cell lines offer an excellent model for the study of the expression of endogenous receptors for the carbohydrate part of glycoconjugates with respect to cell lineage and modulation by differentiation . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
120,
132
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
141,
156
]
} |
this initial description of lineage- and differentiation-dependent differences in various human hematopoietic cell lines and in cells from patients with lowgrade lymphomas suggests that advances in the knowledge of the composition of endogenous sugar receptors ( lectins ) may aid in understanding aspects of the biological behavior of hematopoietic cells and their related malignancies via participation of sugar-protein ( lectin ) interactions . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
414,
421
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
424,
430
]
} |
during chemotherapy , median fpa did not show significant changes whereas , at the end of therapy , a return toward normality was generally observed both in all and anll apart from the group of patients with acute promyelocytic leukaemia . | NA | {
"id": "C0023467",
"name": "anll",
"pos": [
165,
169
]
} | {
"id": "C0023487",
"name": "acute",
"pos": [
208,
213
]
} |
bovine non-amelogenins contain amido-black stainable proteins which are not recognized by lectin , contrary to rat enamel . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
53,
61
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
90,
96
]
} |
if those proteins are albumin or albumin derived , as recently suggested , the observed discrepancy might be explained by the non enzymatic glycation known to occur on circulating albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
9,
17
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
180,
187
]
} |
the use of mucoperiosteal free graft may supply the wounded area with different cells such as fibroblasts , undifferentiated mesenchymal cells , periosteal cells , intercellular fibers and biochemical substances such as glucosaminoglycans , proteoglycans etc ... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} |
25-hydroxyvitamin d3 ( 25 ( oh ) d3 ) and 1,25-dihydroxyvitamin d3 ( 1,25 ( oh ) 2d3 ) concentrations were determined in blood samples obtained from parathyroidectomized ( ptx ) female rats at different time intervals after intramuscular tumor cell inoculation . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
0,
20
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
23,
35
]
} |
populations enriched in hemopoietic stem cells were cloned ( 1 cell/well ) and cultured in the presence of different colony-stimulating factors , or combinations of these growth factors . | NA | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
24,
46
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
63,
67
]
} |
the ability of fibroblastic cells to respond to parathyroid hormone ( pth ) by an increase in adenylate cyclase activity is accepted as a characteristic of the osteogenic phenotype . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
15,
27
]
} |
osteoblast and chondrocyte-containing cultures were clearly distinguished in this way as the former cells secreted type i collagen while the latter secreted types ii and x collagens as the major medium macromolecules . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
100,
105
]
} |
following continent ileostomy or restorative proctocolectomy ileitis can become a serious clinical problem and is then known as pouchitis although this condition is yet to be clearly defined . | NA | {
"id": "C0020877",
"name": "ileitis",
"pos": [
61,
68
]
} | {
"id": "C0376620",
"name": "pouchitis",
"pos": [
128,
137
]
} |
finally , when rats were injected ( i.p . or i.v.t . ) with 3-o-methyl-dopa ( 3-methoxytyrosine ) , a major metabolite of l-dopa , no behavioral change was elicited , and no increase in da was recognized . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
71,
75
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
122,
128
]
} |
correlating the sites of maximal [ 3h ] diprenorphine displacement with the previously described distribution of the opioid peptides suggests that the perforant path fibers release enkephalins in stratum lacunosum moleculare of ca3 and stratum moleculare of the dentate gyrus , and that mossy fibers may release both dynorphins and enkephalins near stratum pyramidale of ca3 and stratum granulosum . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
117,
132
]
} | {
"id": "C0013355",
"name": "dynorphins",
"pos": [
317,
327
]
} |
correlating the sites of maximal [ 3h ] diprenorphine displacement with the previously described distribution of the opioid peptides suggests that the perforant path fibers release enkephalins in stratum lacunosum moleculare of ca3 and stratum moleculare of the dentate gyrus , and that mossy fibers may release both dynorphins and enkephalins near stratum pyramidale of ca3 and stratum granulosum . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
117,
132
]
} | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
332,
343
]
} |
further analysis revealed that regenerating tract gags were comprised of 60 % chondroitin ( 4 or 6 ) sulfate ( cs ) and 40 % heparan sulfate ( hs ) , while unoperated tract gags contained 26 % cs and 74 % hs . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
78,
89
]
} | {
"id": "C0017973",
"name": "gags",
"pos": [
173,
177
]
} |
further analysis revealed that regenerating tract gags were comprised of 60 % chondroitin ( 4 or 6 ) sulfate ( cs ) and 40 % heparan sulfate ( hs ) , while unoperated tract gags contained 26 % cs and 74 % hs . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
50,
54
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
205,
207
]
} |
dual labeling for the beta ar-antibody by the immunoperoxidase method and for a rabbit antiserum against the catecholamine-synthesizing enzyme , tyrosine hydroxylase ( th ) , by the immunoautoradiographic method within the same sections , further established the precise cellular relations between beta ar and catecholaminergic neurons . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
30,
38
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
87,
96
]
} |
the concentration of glutathione ( reduced , gsh + oxidized , gssg ) was high in cultured , differentiated ( i.e . treated with dbcamp ) and undifferentiated ( i.e . untreated ) astrocytes : approximately 25 ( n = 2 ) and 16.0 +/- 5.0 ( n = 7 ) nmol/mg protein , respectively . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
45,
48
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
62,
66
]
} |
for this the trigeminal ganglion was injected with tritiated leucine and wheat germ agglutinin coupled to horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
106,
128
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
131,
138
]
} |
we have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid ( ka ) -model of epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
118,
126
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
163,
171
]
} |
pre-exposure of rats to systemic injections of d-amphetamine sulfate in the presence of bilateral injections of sch-23390 ( 0.5 or 1.0 micrograms/side ) into the ventral tegmental area ( vta ) attenuated the acute locomotor effects of amphetamine and blocked the development of sensitization to amphetamine in a test when only amphetamine was administered , in a dose-dependent manner . | NA | {
"id": "C0282051",
"name": "amphetamine sulfate",
"pos": [
49,
68
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
327,
338
]
} |
the following methods have been introduced at our institute : labeling of human thyroglobulin ( h-tg ) with the radioiodine 125i by the lactoperoxidase method , radioimmunologic method for serum h-tg determination by means of rabbit antiserum to h-tg prepared at our institute , and radioimmunologic method for the determination of antibodies to thyroglobulin . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
233,
242
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
332,
342
]
} |
[ serum hippurate levels in patients with liver cirrhosis under basal conditions and after glucose administration ] . | NA | {
"id": "C0023895",
"name": "liver",
"pos": [
42,
47
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
48,
57
]
} |
[ the effect of noradrenaline , adrenaline and acetylcholine on contractility of the uterus of the guinea pig after testosterone administration ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
16,
29
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
32,
42
]
} |
the reactivity of the isolated guinea pig uterus to norepinephrine , epinephrine , and acetylcholine was evaluated . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
52,
66
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
69,
80
]
} |
hens producing eggs with defective shells as a result of receiving saline drinking water failed to recover the ability to lay eggs with good shells after 8 weeks on normal water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
74,
88
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
172,
177
]
} |
cyproheptadine metabolites inhibit proinsulin and insulin biosynthesis and insulin release in isolated rat pancreatic islets . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
35,
45
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
75,
82
]
} |
measurement of ( pro ) insulin ( proinsulin and insulin ) synthesis using incorporation of 3h-leucine showed that dmcph-epoxide , dmcph and cph-epoxide were 22 , 10 and 4 times , respectively , more potent than cph in inhibiting hormone synthesis . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
33,
43
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
48,
55
]
} |
in heterokaryons formed by fusion of mouse macrophages with he239 cells ( syrian hamster fibroblasts transformed with a ts mutant of the sv40 virus ) , dna synthesis in macrophage nuclei is reactivated only at the permissive temperature ( 33 degrees c ) , at which viral t antigen is stable . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
89,
100
]
} |
intestinal edema , luminal distention , and ischemia are common pathologic processes involved in producing the intestinal damage found during surgical exploration for acute abdominal disorders in the horse . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
44,
52
]
} | {
"id": "C0030660",
"name": "pathologic",
"pos": [
64,
74
]
} |
in equine surgery those conditions commonly producing ischemia are intussusception , volvulus , bowel obstructions , and incarcerated hernias . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
67,
82
]
} | {
"id": "C0021843",
"name": "bowel obstructions",
"pos": [
96,
114
]
} |
in equine surgery those conditions commonly producing ischemia are intussusception , volvulus , bowel obstructions , and incarcerated hernias . | NA | {
"id": "C0042961",
"name": "volvulus",
"pos": [
85,
93
]
} | {
"id": "C0021843",
"name": "bowel obstructions",
"pos": [
96,
114
]
} |
the results showed that insulin resistance was noted in obese non-diabetic and diabetic subjects as well as in non-obese diabetic patients , as evidenced by higher basal iri and lower mcrg than non-obese normal controls . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
24,
42
]
} | {
"id": "C0020459",
"name": "higher",
"pos": [
157,
163
]
} |
this suggests that in spite of sharing common antigenic components between these two fungi , the allergenic components of aspergillus fumigatus is different from those of penicillium sp.. | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
46,
55
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
97,
107
]
} |
previous studies have shown that calcium channel blockers from the dihydropyridine group ( such as nicardipine ) induce an increase in sympathetic tone from a central origin in chronic sinoaortic-denervated ( sad ) dogs . | NA | {
"id": "C2945601",
"name": "calcium channel blockers",
"pos": [
33,
57
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
99,
110
]
} |
verapamil induced a decrease in blood pressure in the two groups of animals , and an increase in heart rate and plasma catecholamines ( noradrenaline and adrenaline ) in normal but not in sad dogs . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
136,
149
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
154,
164
]
} |
plasma concentrations of epinephrine , norepinephrine , and dopamine were simultaneously determined for adrenal venous and aortic blood in dogs anesthetized with sodium pentobarbital . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
39,
53
]
} |
under basal conditions , the net output ( micrograms/min ) of adrenal epinephrine , norepinephrine , and dopamine were 0.169 +/- 0.074 , 0.067 +/- 0.023 , and 0.011 +/- 0.003 , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
84,
98
]
} |
plasma concentrations ( ng/ml ) of aortic epinephrine , norepinephrine , and dopamine were 0.132 +/- 0.047 , 0.268 +/- 0.034 , and 0.034 +/- 0.009 . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} |
following insulin injection ( 0.15 iu/kg , i.v . ) , the net output ( micrograms/min ) of adrenal epinephrine , norepinephrine , and dopamine increased gradually ( p less than 0.05 ) , reaching the values of 0.918 +/- 0.200 , 0.365 +/- 0.058 , and 0.034 +/- 0.007 30 min after insulin administration . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
98,
109
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} |
similarly , aortic epinephrine , norepinephrine , and dopamine concentrations ( ng/ml ) increased significantly ( p less than 0.05 ) to 0.702 +/- 0.144 , 0.526 +/- 0.093 , and 0.066 +/- 0.024 . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
19,
30
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} |
five minutes after the onset of adrx , the net output ( micrograms/min ) of adrenal epinephrine , norepinephrine , and dopamine increased further to 1.707 +/- 0.374 ( p less than 0.05 ) , 0.668 +/- 0.139 ( p less than 0.05 ) , and 0.052 +/- 0.017 . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
84,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} |
therefore , a canine model of arrhythmias produced by the interaction of halothane and catecholamines was used to study the effects of vagal stimulation on the induction of ventricular fibrillation . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
30,
41
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
173,
197
]
} |
vagal stimulation reversibly raised the norepinephrine dose that produced ventricular fibrillation from 16.4 +/- 2.4 to 30.0 +/- 3.8 micrograms ( p less than 0.001 , n = 10 ) , and the epinephrine dose from 15.5 +/- 2.0 to 22.5 +/- 2.6 micrograms ( p less than 0.001 , n = 5 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
40,
54
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
185,
196
]
} |
following atropine , vagal stimulation failed to raise the threshold dose of norepinephrine ( 16.8 +/- 2.4 vs. 18.3 +/- 3.3 micrograms , nonsignificant , n = 6 ) or epinephrine ( 15.5 +/- 2.0 vs. 16.0 +/- 2.3 micrograms , nonsignificant , n = 5 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
77,
91
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
165,
176
]
} |
n-acetyl-d-glucosamine could inhibit the adhesion of the bacteria to rabbit intestinal epithelial cells as could lipopolysaccharide o-antigen from vibrio cholerae 01 and lectin from triticum vulgaris . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
113,
131
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
132,
141
]
} |
the major lipid a species , iva ( o- ( 2-amino-2-deoxy-beta-d-glucopyranosyl ) - ( 1-6 ) -2-amino-2-deoxy-alpha-d - glucose , acylated at positions 2 , 3 , 2 ' , 3 ' with beta-hydroxymyristoyl groups and bearing phosphates at positions 1 and 4 ' ) , was shown to be converted mainly to lps by pulse-chase experiments in the absence of inhibitor . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
10,
17
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
286,
289
]
} |
during chase in the presence of inhibitor , there was no conversion to lps , while the major lipid a species was converted to the same polar lipid a derivatives as in chase without inhibitor . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
71,
74
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
141,
148
]
} |
our data indicate that despite the accumulation of several species of lipid a derivatives during inhibition of lps synthesis , only iva is destined for synthesis of mature lps when lps synthesis resumes . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
70,
77
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
181,
184
]
} |
survival of all three strains was negatively affected in nonsterile agricultural drainage water when compared with survival in sterile water . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
90,
95
]
} | {
"id": "C0359299",
"name": "sterile water",
"pos": [
127,
140
]
} |
furthermore , this toxin induced the elevation of camp in cho cells suggesting thereby that the mechanism of action of aeromonas non-ctc enterotoxin may be similar to heat-labile enterotoxins of escherichia coli and vibrio cholerae . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
19,
24
]
} | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
179,
191
]
} |
the presence of o antigen of the lipopolysaccharide on klebsiella pneumoniae is responsible for the low transformation frequencies observed . | NA | {
"id": "C0069180",
"name": "o antigen",
"pos": [
16,
25
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
33,
51
]
} |
intracranial hemorrhage was noted in 5 patients ( 28 % ) , including one case of fatal intracerebral hemorrhage following an acute hypertensive episode after the transplantation . | NA | {
"id": "C0151699",
"name": "intracranial hemorrhage",
"pos": [
0,
23
]
} | {
"id": "C2937358",
"name": "intracerebral hemorrhage",
"pos": [
87,
111
]
} |
while systemic infection was common ( 10 patients ) , there were only 5 cases of intracranial infection ; | NA | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
6,
24
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
94,
103
]
} |
tropical spastic paraparesis should be considered in all patients with myelopathy , even those without standard serological markers of htlv-1 infection . | NA | {
"id": "C0030481",
"name": "tropical spastic paraparesis",
"pos": [
0,
28
]
} | {
"id": "C0020097",
"name": "htlv-1",
"pos": [
135,
141
]
} |
sodium dodecyl sulfate was removed from the sds-protein complexes by the extraction of dodecyl sulfate anions as ion pairs with triethylammonium cations into an organic solvent . | NA | {
"id": "C0037506",
"name": "sds",
"pos": [
44,
47
]
} | {
"id": "C0058632",
"name": "dodecyl sulfate",
"pos": [
87,
102
]
} |
sodium dodecyl sulfate was removed from the sds-protein complexes by the extraction of dodecyl sulfate anions as ion pairs with triethylammonium cations into an organic solvent . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
103,
109
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
148,
151
]
} |
while the syndrome has been recognized for some time , diagnostic criteria for the disorder have not yet been established or evaluated . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
10,
18
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
83,
91
]
} |
the antibody exhibited reduced cross-reactivity with closely related tallysomycin analogs and little or no immunoreactivity with other antitumor antibiotics including bleomycin and phleomycin . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
167,
176
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
181,
191
]
} |
antiserum raised in rabbits against extracts of sinus glands from carcinus annd shown by several criteria to contain antibodies directed against the neurosecretory hyperglycemic hormone was used to locate the hormone-producing perikarya in the optic ganglia . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
117,
127
]
} |
a retrospective study on amoebiasis observed in the central hospital in nantes since twenty years , shows that , at least , 16 % of the intestinal cases and 1/6 , 5 of 30 cases of hepatic amoebiasis are autochthonous . | NA | {
"id": "C0002438",
"name": "amoebiasis",
"pos": [
25,
35
]
} | {
"id": "C0023886",
"name": "hepatic amoebiasis",
"pos": [
180,
198
]
} |
approximately 1000-4000 cases of equine encephalitis occur annually in the united states , the majority due to wee . | NA | {
"id": "C0014074",
"name": "equine encephalitis",
"pos": [
33,
52
]
} | {
"id": "C0153064",
"name": "wee",
"pos": [
111,
114
]
} |
the frequency of barr-bodies in cultivated 46 xx human fibroblasts considerably increases when in confluent monolayer cultures the cells no longer divide . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
131,
136
]
} |
this high toxicity , specific for diptera larvae such as mosquitoes and blackflies , is related to the special characteristic of the bacterial crystal protein which has a clear serological and chemical individuality compared to the crystal proteins of the other b. thuringiensis serotypes essentially pathogenic for lepidoptera larvae . | NA | {
"id": "C0004627",
"name": "bacterial",
"pos": [
133,
142
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
240,
248
]
} |
in vitro and in vivo studies of the biological activities of these antibodies have led to the identification of ige antibodies with a high reaginic activity and antibodies which in a complement dependent or eosinophil dependent system were shown to have a marked cytotoxicity for schistosomula in vitro . | NA | {
"id": "C0034761",
"name": "reaginic",
"pos": [
139,
147
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
161,
171
]
} |
a series of five living patients with juvenile metachromatic leukodystrophy ( mld ) , ten first-degree relatives , and a number of controls were subjected to biochemical investigations including quantitative determination of arylsulphatase a ( asa ) and b ( asb ) activities in peripheral leukocytes and polyacrylamide disc gel elctrophoresis of arylsulphatases . | NA | {
"id": "C0007804",
"name": "arylsulphatase a",
"pos": [
225,
241
]
} | {
"id": "C0003940",
"name": "arylsulphatases",
"pos": [
346,
361
]
} |
however , this antibody was shown to be present in the ic isolate in eight patients . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
15,
23
]
} | {
"id": "C0003313",
"name": "ic",
"pos": [
55,
57
]
} |
the progressive appearance of multiple urinary bence-jones proteins and serum paraproteins in a child with immune deficiency . | NA | {
"id": "C0004965",
"name": "bence-jones proteins",
"pos": [
47,
67
]
} | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
78,
90
]
} |
multiple urinary bence-jones proteins and serum paraproteins were found in a child with type i dysgammaglobulinaemia ( seligmann et al. , 1968 ) . | NA | {
"id": "C0004965",
"name": "bence-jones proteins",
"pos": [
17,
37
]
} | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
48,
60
]
} |
in the third month of treatment , the tests were repeated on day 21 , i.e . after 21 active pills , and on day 28 , i.e . after 21 active and 7 inactive tablets . | NA | {
"id": "C0994475",
"name": "pills",
"pos": [
92,
97
]
} | {
"id": "C0039225",
"name": "tablets",
"pos": [
153,
160
]
} |
[ early diagnosis of ileus by the gastrointestinal passage of a resorbable contrast medium and of recurrent intestinal obstruction ] . | NA | {
"id": "C1258215",
"name": "ileus",
"pos": [
21,
26
]
} | {
"id": "C0021843",
"name": "of",
"pos": [
95,
97
]
} |
[ nutritional problems in surgical patients in a grave condition . enteral hypernutrition by nutripump and autoregulated reinstillation of chyme ( author 's transl ) ] . | NA | {
"id": "C3714509",
"name": "nutritional problems",
"pos": [
2,
22
]
} | {
"id": "C1257763",
"name": "hypernutrition",
"pos": [
75,
89
]
} |
the authors examined patients with psoriatic arthropathy and pure dermatological psoriasis but found only association with b 17 and b 13 . | NA | {
"id": "C0003872",
"name": "psoriatic",
"pos": [
35,
44
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
81,
90
]
} |
there was no operative mortality , and morbidity was confined to problems related to two patients with intestinal obstruction , one with fecal impaction , and one with wound infection . | NA | {
"id": "C0021843",
"name": "intestinal obstruction",
"pos": [
103,
125
]
} | {
"id": "C0015734",
"name": "fecal",
"pos": [
137,
142
]
} |
differences in aza and 6-mp kinetics among the monkeys were attributed to differences in individual aldehyde oxidase and xanthine oxidase levels . | NA | {
"id": "C0004482",
"name": "aza",
"pos": [
15,
18
]
} | {
"id": "C0000618",
"name": "kinetics",
"pos": [
28,
36
]
} |
chlorphentermine and methadone formed sep 's in the ipl of comparable size to that formed with imip , whereas phentermine formed a considerably smaller sep . | NA | {
"id": "C0008283",
"name": "chlorphentermine",
"pos": [
0,
16
]
} | {
"id": "C0031447",
"name": "phentermine",
"pos": [
110,
121
]
} |
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