text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
our data suggest that as the tibiotarsus grows in length the small , round rapidly dividing cells of the tibia differentiate first to flattened chondrocytes which synthesize matrix at a high rate and ultimately to low activity , hypertrophying chondrocytes . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
25,
28
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
244,
256
]
} |
homogenates of tritrichomonas foetus exhibited a mg2+-dependent adenosine triphosphatase ( atpase ) activity , with a ph optimum in tris buffers of 8.2 to 8.3 . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
49,
52
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
91,
97
]
} |
examination of the pigments extracted from these mutants indicated that at least 15 carotenoids were formed . beta-carotene was not detected and the major carotene of m. aurum appeared to be leprotene . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
84,
95
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
110,
123
]
} |
preliminary studies suggested that the enzyme is active against chondroitin 4- and 6-sulphates , but not against dermatan sulphate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
64,
75
]
} | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
113,
130
]
} |
this was consistent with the amino acid composition , which showed it to be rich in serine , alanine and leucine with approximately half of its glutamic and aspartic acid residues amidified , and the isoelectric point of 6.0 , as determined by two dimensional gel analysis . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
29,
39
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
93,
100
]
} |
in the median eminence and posterior pituitary the accumulation of dopa appears to occur primarily in da nerves since : ( 1 ) the rate of synthesis of norepinephrine ( ne ) , as estimated from the alpha-methyltyrosine-induced decline of catecholamines , accounts for less than 10 % of total catecholamine synthesis in these two brain regions ; | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
67,
71
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
237,
251
]
} |
prognosis quoad vitam of early epilepsy seems to be favourable , however , in severely brain-injured patients , seizures occur more frequently and may determine a worsening of the clinical picture even if they are not responsible for the death . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
31,
39
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
112,
120
]
} |
the bioavailability of the esters bacampicillin ( 86 +/- 11 % ) and pivampicillin ( 92 +/- 18 % ) was significantly greater than that of ampicillin ( 62 +/- 17 % ) ; | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
68,
81
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
137,
147
]
} |
the adsorption rate was highest for bacampicillin ( 0.89 +/- 0.39 of dose absorbed per minute ) , followed by pivampicillin ( 0.64 +/- 0.19 ) and ampicillin ( 0.58 +/- 0.16 ) . | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
110,
123
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
146,
156
]
} |
analysis of betamethasone and betamethasone valerate mixtures by measuring absorbance values at two different times was performed also . | NA | {
"id": "C0005308",
"name": "betamethasone",
"pos": [
12,
25
]
} | {
"id": "C0750848",
"name": "betamethasone valerate",
"pos": [
30,
52
]
} |
the results suggest that the iodine in povidone-iodine usp is complexed by the polymer such that a proton is fixed via a short hydrogen bond between two carbonyl groups of two pyrrolidone rings and that a triiodide anion is bound ionically to this cation . | NA | {
"id": "C0021966",
"name": "iodine",
"pos": [
29,
35
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
215,
220
]
} |
to understand hydrazone formation in hydralazine metabolism , the reaction of hydralazine with various biogenic aldehydes and ketones ( acetone , pyruvic acid , acetoacetic acid , formaldehyde , and acetaldehyde ) in ph 7.4 buffer was studied for potential alterations in hydralazine pharmacokinetics secondary to alcoholism and diabetes . | NA | {
"id": "C0022634",
"name": "ketones",
"pos": [
126,
133
]
} | {
"id": "C0001002",
"name": "acetone",
"pos": [
136,
143
]
} |
the inhibitory effect of other monovalent anions on the chloride transport was investigated by measuring the 36cl- efflux into media where either bromide , nitrate , or thiocyanate had been substituted for part of the chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
42,
48
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
146,
153
]
} |
the inhibitory effect of other monovalent anions on the chloride transport was investigated by measuring the 36cl- efflux into media where either bromide , nitrate , or thiocyanate had been substituted for part of the chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
42,
48
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
156,
163
]
} |
the inhibitory effect of other monovalent anions on the chloride transport was investigated by measuring the 36cl- efflux into media where either bromide , nitrate , or thiocyanate had been substituted for part of the chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
42,
48
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
218,
226
]
} |
interest of this examination in the diagnosis of sinusian cyst of polypus , apical teeth cyst growing in the sinus , fistula from mouth to sinus , repeating sinusitis by dental infectious focus , sinusian stranger corps and finally , in the schedule or surveillance of the extension of sinus maxillary cancer to the posterior wall , particularly to the pterygomaxillary fossae . | NA | {
"id": "C0079943",
"name": "fistula",
"pos": [
117,
124
]
} | {
"id": "C0016169",
"name": "sinus",
"pos": [
286,
291
]
} |
serum levels of carrier proteins , transferrin , ceruloplasmin and albumin were determined in patients with rheumatic disorders , along with serum levels of acute phase proteins , ceruloplasmin , alpha 1-acid glycoprotein and alpha 1-antitrypsin . | NA | {
"id": "C0040679",
"name": "transferrin",
"pos": [
35,
46
]
} | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
157,
177
]
} |
serum levels of carrier proteins , transferrin , ceruloplasmin and albumin were determined in patients with rheumatic disorders , along with serum levels of acute phase proteins , ceruloplasmin , alpha 1-acid glycoprotein and alpha 1-antitrypsin . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
157,
177
]
} | {
"id": "C0007841",
"name": "ceruloplasmin",
"pos": [
180,
193
]
} |
serum levels of carrier proteins , transferrin , ceruloplasmin and albumin were determined in patients with rheumatic disorders , along with serum levels of acute phase proteins , ceruloplasmin , alpha 1-acid glycoprotein and alpha 1-antitrypsin . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
157,
177
]
} | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
196,
221
]
} |
serum levels of carrier proteins , transferrin , ceruloplasmin and albumin were determined in patients with rheumatic disorders , along with serum levels of acute phase proteins , ceruloplasmin , alpha 1-acid glycoprotein and alpha 1-antitrypsin . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
157,
177
]
} | {
"id": "C0002191",
"name": "alpha",
"pos": [
226,
231
]
} |
parenteral iron therapy is effective in these instances and may produce a faster response than the oral route.of 30 patients treated by total dose intravenous infusion of iron-dextran , a prompt reticulocytosis occurred in all patients except one case associated with systemic lupus erythematosus . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
11,
15
]
} | {
"id": "C0022092",
"name": "iron-dextran",
"pos": [
171,
183
]
} |
one case of kartagener syndrome , pulmonary aspergillosis , poliomyelitis , and aspiration of a foreign body were associated with bronchiectasis . | NA | {
"id": "C0022521",
"name": "kartagener syndrome",
"pos": [
12,
31
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
130,
144
]
} |
although the basal diet contained 1.8 % arginine and was therefore not arginine-deficient , supplementation of the diet and the drinking water with 0.5 % arginine hcl reduced tumor incidence , lengthened the latency period , decreased tumor size , and hastened tumor regression . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
40,
48
]
} | {
"id": "C0301556",
"name": "arginine hcl",
"pos": [
154,
166
]
} |
blood amino acid concentrations of alanine , valine , leucine , and isoleucine were similar , whereas those of phenylalanine , histidine , serine , and arginine were higher , and glutamine lower , in the 1.83 g/kg group . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
6,
16
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
117,
124
]
} |
dna obtained from 29 male humans at autopsy was hybridized in liquid phase with tritium-labelled 18 and 28s ribosomal rna ( rrna ) in order to determine whether a change in the dosage in rdna , which codes for rrna , occurs during human aging . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
187,
191
]
} |
the administration of 0.2 % of the amino acid analogues canavanine and 6-fluorotryptophan to young nematode cultures caused the appearance of inactive but antigenically reactive aldolase molecules at levels comparable to those found in old untreated cultures . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
35,
45
]
} | {
"id": "C0006825",
"name": "canavanine",
"pos": [
56,
66
]
} |
failure of beta-endorphin antiserum , naloxone , and naltrexone to alter physiologic growth hormone and insulin secretion . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
38,
46
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
53,
63
]
} |
the concentration of renal cholesterol , phospholipids ( pl ) , triglycerides ( tg ) and cholesteryl esters ( ce ) were also decreased . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
27,
38
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
89,
107
]
} |
the phosphatidylcholine and phosphatidylethanolamine had distinctive fatty acid distributions for position sn-2 of the triacylglycerol had a predominance of unsaturated fatty acids of which 18:1 ( 69.9 % ) was the major component . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
69,
79
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
157,
180
]
} |
methanol , ethanol , propanol , and isopropanol , added at concentrations which inhibited growth by 50 % , stimulated phospholipase a , but not lysophospholipase activity . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
0,
8
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
11,
18
]
} |
methanol , ethanol , propanol , and isopropanol , added at concentrations which inhibited growth by 50 % , stimulated phospholipase a , but not lysophospholipase activity . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
1,
8
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
36,
47
]
} |
it could be shown that dapi , a newer fluorochrome ( 4',6-diamidino-2-phenylindole ) , is able to stain various types of acid mucopolysaccharides , e.g . heparin and agar mucopolysaccharides . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
154,
161
]
} | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
171,
190
]
} |
at the same time , the content of glutamine , asparagine , alanine , methionine , cysteine and other free amino acids increases in the substrate . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
59,
66
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
106,
117
]
} |
the results of this study support the concept that locally produced antisperm antibody contributes to conception failure in a subgroup of infertile women , and that the routine study both of sera and of vaginal washings of infertile patients has practical value . | NA | {
"id": "C0021361",
"name": "infertile women",
"pos": [
138,
153
]
} | {
"id": "C0021359",
"name": "infertile",
"pos": [
223,
232
]
} |
two cases of the syndrome of bronchiectasis , chronic sinusitis and dextrocardia with situs inversus ( kartagener 's syndrome ) are described . | NA | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
29,
43
]
} | {
"id": "C0022521",
"name": "kartagener 's syndrome",
"pos": [
103,
125
]
} |
n6-phenylisopropyladenosine produced only partial inhibition ( 30 % ) of 3h-adenosine binding and no stereospecific difference between the ( - ) - and ( + ) isomer was observed . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
3,
27
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
76,
85
]
} |
increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine , dihydralazine and minoxidil . | NA | {
"id": "C0020223",
"name": "hydralazine",
"pos": [
108,
119
]
} | {
"id": "C0012271",
"name": "dihydralazine",
"pos": [
122,
135
]
} |
in the fasting subject , when this compartment has exhausted its remains , the failure of the nefa picture to correspond to that of the fats constituting the stabel pool may be attributable to selective release , or to preferential utilisation of each fatty acid . | NA | {
"id": "C0015688",
"name": "nefa",
"pos": [
94,
98
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
252,
262
]
} |
( + ) - and ( - ) -baclofen were equiactive in inducing contralateral rotational behaviour following their unilateral injection into the zona reticulata of the rat substantia nigra , a proposed gaba-dependent rotational behaviour model , and in displacing the specific binding of [ 3h ] gaba to frozen and thawed membrane preparations of rat brain . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
19,
27
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
287,
291
]
} |
on the contrary , as previously found , the two dopaminergic ergot derivatives did not stimulate dopamine-senstiive adenylate cyclase present in striatal homogenates . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
48,
60
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
97,
105
]
} |
in slices of rat hippocampus , adenosine and its receptor agonist , 2-chloro-adenosine , were both found to ( a ) enhance the intracellular accumulation of cyclic adenosine monophosphate ( camp ) and ( b ) depress neuronal evoked responses to electrical stimulation . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
31,
40
]
} | {
"id": "C0000275",
"name": "2-chloro-adenosine",
"pos": [
68,
86
]
} |
the rat ventral tegmentum ( containing dendrites and somata of mesolimbic dopaminergic neurones ) possessed high levels of dopamine and tyrosine hydroxylase . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
74,
86
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
123,
131
]
} |
the vena cava neuropil may represent a favourable system for the examination of the physiological role of the opioid peptide enkephalin . | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
110,
124
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
125,
135
]
} |
the central noradrenaline ( na ) and adrenaline ( a ) turnover in 15 -- 16-week-old stroke prone , spontaneously hypertensive ( sp-sh ) female rats in an advanced stage of hypertension was found to differ from that of normotensive wistar-kyoto ( wky ) control rats . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
12,
25
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
37,
47
]
} |
the predominant clinical findings were : tachycardia , paroxysmal dyspnea , cyanosis , metabolic acidosis , congestive heart failure and , in the ecg , cardiac arrhythmias and t-wave inversions in the left precordial chest leads . | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
16,
33
]
} | {
"id": "C0010520",
"name": "cyanosis",
"pos": [
76,
84
]
} |
venous bleeding occurred in 6 infants after vessel disruption and 1 arterial hematoma in a boy because of incomplete compression of puncture site . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
7,
15
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
77,
85
]
} |
sepsis and non-septic shock in pregnancy show characteristic modifications which are caused a ) by physiologic changes in hemostasis primarily in the third trimester of pregnancy , b ) by etiologic distinctions of shock regarded as pregnancy-specific , c ) by hemodynamic changes in the circulation during pregnancy , d ) by the ability of the healthy , young organism to compensate adequately . | NA | {
"id": "C0032981",
"name": "third",
"pos": [
150,
155
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
306,
315
]
} |
these data confirm the theory described previously by the authors on the existence of two possible methods of polymer destruction in aggressive mediums passing through total volume and on the plastic surface only . | NA | {
"id": "C0032521",
"name": "polymer",
"pos": [
110,
117
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
192,
199
]
} |
ammonia gas was injected at 0 , 50 , or 100 ppm from 28 to 53 days of age . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
0,
7
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
8,
11
]
} |
no significant differences were found in mortality , but weight gains were significantly reduced in chambers that received ammonia gas . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
123,
130
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
131,
134
]
} |
it is suggested that either doses of hcg and cpe used in this study were not enough or non-breeding pheasants require pheasant gonadotropins for the complete recovery of testicular function . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
37,
40
]
} | {
"id": "C0018061",
"name": "gonadotropins",
"pos": [
127,
140
]
} |
the terms acute and chronic should retain their clinical significance , the term aggressive should retain a histological significance and , insofar as the piecemeal necrosis which characterises it is seen in both types of hepatitis , it should be dissociated , in terms of classification , from chronic hepatitis . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
222,
231
]
} | {
"id": "C0019189",
"name": "chronic hepatitis",
"pos": [
295,
312
]
} |
a single dose of gaba-t inhibitors , gamma-vinyl gaba ( 1200 mg/kg , ip ) or gamma-acetylenic gaba ( 100 mg/kg , ip ) administered 4 hours prior to ketamine , shortened the first rotation phase , increased the anesthetic phase , changed the pattern of postanesthetic rotation and reduced total and net rotation scores . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
17,
21
]
} | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
37,
53
]
} |
norepinephrine n-methyltransferase ( nmt ; the epinephrine-forming enzyme ) from pigeon brain had km values for s-adenosyl-l-methionine and l-norepinephrine of 24 +/- 1 and 101 +/- 4 micrometer , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
3,
14
]
} | {
"id": "C0028351",
"name": "l-norepinephrine",
"pos": [
140,
156
]
} |
excesses of essential elements ( both trace and major ) give rise to toxic effects and the importance of a proper balance especially of the transitional elements in the human diet is discussed with special reference to cu , zn and fe . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
22,
30
]
} | {
"id": "C0682906",
"name": "transitional elements",
"pos": [
140,
161
]
} |
these results suggest a change in glucose oxidation by a route that can not be explained solely by changes in either the hexose monophosphate or embden-meyerhof pathways . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
34,
41
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
121,
127
]
} |
pretreatment with noradrenergic blocking agents ( propranolol , phentolamine and phenoxybenzamine ) did not diminish the suppressant effect of d-amphetamine , but this effect was reduced by pretreatment with alpha-methyl-para-tyrosine methylester and dopamine blockers ( spiroperidol , haloperidol and clozapine ) indicating that d-amphetamine was exerting its selective suppressant effect via the release of dopamine . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
145,
156
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
330,
343
]
} |
[ the effect of chloramphenicol on sleep in cat -- comparison with thiamphenicol , erythromycine , and oxytetracycline ( author 's transl ) ] . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
16,
31
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
67,
80
]
} |
when cap is injected after tap , the sp inhibition is longer than after cap alone . | NA | {
"id": "C0039854",
"name": "tap",
"pos": [
27,
30
]
} | {
"id": "C0008168",
"name": "cap",
"pos": [
72,
75
]
} |
slow wave sleep is decreased only with high doses of cap and is unaffected by tap , oxytetracycline or erythromycine . | NA | {
"id": "C0008168",
"name": "cap",
"pos": [
53,
56
]
} | {
"id": "C0039854",
"name": "tap",
"pos": [
78,
81
]
} |
in cases of bile stasis , cg/slcg ratios ranged from 7.8 +/- 4.8 for intrahepatic cholestasis to 34.8 +/- 27.6 for congenital biliary atresia , while other hepatic disorders demonstrated relatively low values . | NA | {
"id": "C0008370",
"name": "bile stasis",
"pos": [
12,
23
]
} | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
69,
93
]
} |
effects of clofibrate on plasma lecithin : cholesterole acyltransferase ( lcat ) activity , plasma lipid levels and hepatic cholesterol content were examined in rats with clofibrate treatment for a short period of time . | NA | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
56,
71
]
} | {
"id": "C0023194",
"name": "lcat",
"pos": [
74,
78
]
} |
the clinical , epidemiological and laboratory investigations established the hydric origin of the dysentery due to shigella flexneri 3 a , caused by the illicit communication of the drinking water and industrial water mains . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
182,
196
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
212,
217
]
} |
although it produces minimal increases in prothrombin and partial thromboplastin times in healthy volunteers , it does not significantly affect the individual clotting factors , nor does it , in patients , enhance the effect of acenocoumarol or phenprocoumon . | NA | {
"id": "C0033706",
"name": "prothrombin",
"pos": [
42,
53
]
} | {
"id": "C0005789",
"name": "clotting factors",
"pos": [
159,
175
]
} |
biopsies from musculis quadriceps femoris of man were analyzed for ph , atp , adp , cp , creatine , lactate and pyruvate . | NA | {
"id": "C0031634",
"name": "cp",
"pos": [
84,
86
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
89,
97
]
} |
leucine was incorporated linearly with time into kidney cortex and tumour proteins during hypothermic perfusion but the incorporation rate was 3-4 times higher into kidney cortex proteins than into tumour proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
74,
82
]
} | {
"id": "C0027642",
"name": "tumour proteins",
"pos": [
198,
213
]
} |
arterial plasma acetate , glucose and nefa concentrations were measured during loading with glucose/insulin and fat emulsion/heparin , and during epinephrine and norepinephrine stimulation in dogs . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
146,
157
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
162,
176
]
} |
in order to investigate the consequences of presence of aggregates in human albumin standards , pools of monomer , dimer and polymer albumin were prepared and quantitated by three total-protein methods ( biuret , folin-lowry and spectrophotometry at 279 nm ) and by four different albumin methods ( dye-binding by bromcresol green , electroimmunoassay , radial immunodiffusion and automated immunoprecipitation ) . | NA | {
"id": "C0304925",
"name": "human",
"pos": [
70,
75
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
281,
288
]
} |
the distribution of isoenzymes and of enzymes in blood from women at delivery was investigated also . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
20,
30
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
38,
45
]
} |
in 45 patients with inflammatory bowel disease ( 9 with crohn 's disease and 36 with ulcerative colitis ) and associated liver disorders , increased liver copper content ( above 100 microgram/g dry weight ) was found in 14 ( 31 % ) . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
20,
46
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
56,
72
]
} |
plasma secretin was not affected by gastric suction or by prolonged infusion of pentagastrin , whereas serum gastrin fell during secretion infusion accompanied by gastric suction . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
80,
92
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
109,
116
]
} |
the normal lack of response of dba/2 lymph node cells to the syngeneic tumour p815 in vitro can not be attributed to a lack of cytotoxic precursor cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
137,
152
]
} |
in the remaining eight patients , tumour of the urinary bladder was the initial diagnosis , but tumours of the upper urinary tract subsequently appeared . | NA | {
"id": "C0005695",
"name": "tumour of the urinary bladder",
"pos": [
34,
63
]
} | {
"id": "C0042076",
"name": "tumours of the",
"pos": [
96,
110
]
} |
it is also suggested , that at-iii levels may be high in active renal disease , decreasing as uremia advances . | NA | {
"id": "C0022658",
"name": "renal disease",
"pos": [
64,
77
]
} | {
"id": "C0041948",
"name": "uremia",
"pos": [
94,
100
]
} |
of 874 morphologically classified tumours , squamous cell composed 45 % , undifferentiated large cell 17 % , small cell anaplastic 14 % , adenocarcinoma 19 % , carcinoid 2 % and others 3 % . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
138,
152
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
160,
169
]
} |
this effect is significantly decreased when the mice have been treated with either ethane-hydroxy-diphosphonate ( ehdp ) or dichloromethylene-diphosphonate ( cl2mdp ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
98,
111
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
158,
164
]
} |
in 29 patients with fractures of the femoral neck ( group a ) and 22 patients operated on for osteoarthritis of the hip ( group ) b ) , plasma levels of 25-hydroxycholecalciferol ( 25-oh-d3 ) were compared with the results of histological bone tests . | NA | {
"id": "C0006657",
"name": "25-hydroxycholecalciferol",
"pos": [
153,
178
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
181,
189
]
} |
killing curves of pseudomonas aeruginosa were performed in an in vitro system simulating in-vivo gentamicin kinetics , i.e . decay of the antibiotic concentration with a 2.1 h halflife time . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
108,
116
]
} | {
"id": "C0018517",
"name": "halflife",
"pos": [
176,
184
]
} |
attempts to transfer the erythromycin resistance of either the mutants or naturally resistant lines by fusion of cytoplasts with sensitive cells were unsuccessful , and it is concluded that resistance to erythromycin stearate is controlled by nuclear genetic factors . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
25,
37
]
} | {
"id": "C0059566",
"name": "erythromycin stearate",
"pos": [
204,
225
]
} |
the clonal variation in the rate of albumin production in cultured rat hepatoma cells has been studied on a cellular basis by immunoperoxidase techniques using specific antisera against rat serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
36,
43
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
190,
203
]
} |
hizikia-arsenic could be absorbed at the rate comparable to arsenic trioxide , and accumulated primarily in blood . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
8,
15
]
} | {
"id": "C0052416",
"name": "arsenic",
"pos": [
60,
67
]
} |
intake and excretion of arsenic from hizikia-diet reached a steady state within 4 days of administration as was the case of arsenic trioxide . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
24,
31
]
} | {
"id": "C0052416",
"name": "arsenic trioxide",
"pos": [
124,
140
]
} |
this paper reports the bodily distribution of total cobalamin and individual cobalamins at the termination of an experiment on the effects of a low cobalamin diet and chronic cyanide or thiocyanate administration in baboons . | NA | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
52,
61
]
} | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
77,
87
]
} |
predictive value of hla-dr matching for nonreactivity in mixed lymphocyte culture ( mlc ) depends on matching for hla-d . | NA | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
20,
26
]
} | {
"id": "C0019754",
"name": "hla-d",
"pos": [
114,
119
]
} |
the comparison of their chemical structures with the cluster analysis obtained by cytotoxicity suggests that antibodies reacting with large antigenic structures ( pentasaccharides ) have a more restricted specificity than antibodies reacting only with smaller antigenic determinants ( trisaccharides ) . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
140,
149
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
260,
269
]
} |
renal water loss is determined by the circulating level of the antidiuretic hormone , arginine vasopressin ( avp ) . | NA | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
63,
83
]
} | {
"id": "C0003779",
"name": "arginine vasopressin",
"pos": [
86,
106
]
} |
depolarization of the neurosecretory neurons results in the exocytosis of the granules and the release of avp and its carrier protein ( neurophysin ) into the circulation . | NA | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
118,
133
]
} | {
"id": "C0027900",
"name": "neurophysin",
"pos": [
136,
147
]
} |
the absorption , metabolism and excretion of isamoxole , ( 2-methyl-n-butyl-n- ( 4-methyloxazol-2-yl ) propanamide ) , a compound with anti-allergy properties , has been studied in the rat and guinea-pig . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
the metabolism of 2-chloropropane-1,3-diol has been investigated in the rat and the isolation of one mercapturic acid , n-acetyl-s- ( 2,3-dihydroxypropyl ) cysteine , confirms that an epoxide intermediate is involved . | NA | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
101,
117
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
156,
164
]
} |
the previously known metabolites have been isolated and confirmed as the three mercapturic acids n-acetyl-s-propyl cysteine , n-acetyl-s-propyl cysteine-s-oxide and n-acetyl-s- ( 2-hydroxypropyl ) cysteine . | NA | {
"id": "C0001047",
"name": "mercapturic acids",
"pos": [
79,
96
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
197,
205
]
} |
the metabolites of 3-bromopropanol and 3-chloropropanol in the rat have been shown to be the mercapturic acids n-acetyl-s- ( 3-hydroxypropyl ) cysteine and n-acetyl-s- ( 2-carboxyethyl ) cysteine and the corresponding 2-carboxyethyl halide . | NA | {
"id": "C0001047",
"name": "mercapturic acids",
"pos": [
93,
110
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
187,
195
]
} |
this increase depends on the time elapsed and is explained by the relatively high stability of this fraction compared to organ proteins , which appear in the globulin region . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
127,
135
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
158,
166
]
} |
the following examination procedures have been used for diagnosis of intra-uterine pathological signs : hysteroscopy , prior to and following curretage , radio-isotope diagnosis of the endometrium , quantitative measurement of nucleic acids ( rna and dna ) in the endometrium , determination of mitosis in the endometrium , assessment of hormonal condition in the organisms , with reference to findings of the karyopycnotic index , and quantitative radio-immunochemical hormone determination . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
227,
240
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
251,
254
]
} |
concentrations and activities of the following agents were estimated : triiodothyronine ( t3 ) , thyroxine ( t4 ) , effective thyroxine ( etr ) , thyreotrophin ( tsh ) , and growth hormone ( hgh ) . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
174,
188
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
191,
194
]
} |
the notion of infertility is expanded to cover not only habitual abortions ( three or more miscarriages ) but , as well , deliveries of defective children . | NA | {
"id": "C0000809",
"name": "habitual abortions",
"pos": [
56,
74
]
} | {
"id": "C0000786",
"name": "miscarriages",
"pos": [
91,
103
]
} |
during the maximum period of a fibrillogenesis the fibroblasts enlarged , acquired a fusiform outline and long processes , exhibited a roughened surface and were surrounded with small rounded cell particles polymerizing into fine fibrils . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
192,
196
]
} |
in 11 of the cases of lobular neoplasia , the dna values fell within the diploid range and in the 3 remaining cases within the diploid to tetraploid range , while the 5 invasive lobular carconomas showed a dna distribution between the diploid and tetraploid ranges . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
204,
209
]
} |
we have concentrated our studies on the less common features of childhood psoriasis : the generalized pustular infantile form , congenital psoriatic erythroderma , acquired psoriatic erythroderma , and infantile arthropathic psoriasis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
74,
83
]
} | {
"id": "C0003872",
"name": "arthropathic psoriasis",
"pos": [
212,
234
]
} |
levels of retinol ( vitamin a ) , carotenoids and triglycerides in the serum of 50 children with homozygous beta-thalassemia have been studied , as well as the ability of the small intestine to absorb a test meal containing retinol palmitate , triglyceride , d-xylose and glucose . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
20,
29
]
} | {
"id": "C0073115",
"name": "retinol",
"pos": [
224,
231
]
} |
serum glutamic oxalacetic transaminase , glutamic pyruvic transaminase , gamma-glutamyl transpeptidase and glutamic dehydrogenase levels in favism . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
26,
38
]
} | {
"id": "C0001899",
"name": "glutamic pyruvic transaminase",
"pos": [
41,
70
]
} |
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