text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the 10-fold difference in the size of the sep for compounds known to induce pulmonary phospholipidosis ( chlorphentermine and imip ) and known not to induce lipidosis ( phentermine and amphetamine ) may suggest a possible involvement of the sep in the onset of phospholipidosis ; | NA | {
"id": "C0008283",
"name": "chlorphentermine",
"pos": [
105,
121
]
} | {
"id": "C0031447",
"name": "phentermine",
"pos": [
169,
180
]
} |
treatment of the animals with the mammalian antidiuretic hormone , arginine vasopressin , results in a prolonged duration of such tolerance , in comparison to animals exposed to ethanol but not to the hormone . | NA | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
44,
64
]
} | {
"id": "C0003779",
"name": "arginine vasopressin",
"pos": [
67,
87
]
} |
carboxypeptidase i , like several other plant carboxypeptidases such as carboxypeptidase c which have now ( iub recommendations 1978 ) been classified as serine carboxypeptidases ( ec 3.4.16.1 ) , has maximum activity around ph 5 and has esterase activity . | NA | {
"id": "C0007075",
"name": "carboxypeptidase",
"pos": [
0,
16
]
} | {
"id": "C0108471",
"name": "carboxypeptidases",
"pos": [
161,
178
]
} |
a second group of proteases , proteinase ii and carboxypeptidase ii , separated from the above on carboxymethyl-cellulose , were shown to have different molecular weight properties and be equally sensitive to serine and thiol group inhibitors . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
18,
27
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
30,
40
]
} |
the decrease of the relative amount of labeled esterases with time was found to follow first-order kinetics yielding an average esterase degrading constant of 0.0165 h-1 which corresponds to a half-life of 42 h . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
99,
107
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
193,
202
]
} |
hclo4 releases the atp unchanged from the enzyme . atpb and enzyme . atpb . atpa complexes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
42,
48
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
60,
66
]
} |
atpb appears unable to dissociate from the enzyme . atpb . hco3- . atpa complex since the t1/2 for dissociation of atpb from the enzyme is lengthened about five times in the presence of 19 mm hco3- and at 1 mm atp . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
43,
49
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
129,
135
]
} |
to refine the secondary structure model of the 5 ' end of the bacteriophage ms2 genome , 32p-labeled ms2 rna was partially digested with t1 rnase or with cm-rnase and the 5'-end fragment was isolated , renatured and submitted to treatment with methoxyamine or kethoxal . | NA | {
"id": "C0018364",
"name": "t1 rnase",
"pos": [
137,
145
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
157,
162
]
} |
the pharmacokinetics of fenfluramine enantiomers were studied in normal volunteers following the administration of single of multiple doses of racemic fenfluramine hydrochloride . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
24,
36
]
} | {
"id": "C0282179",
"name": "fenfluramine hydrochloride",
"pos": [
151,
177
]
} |
however following chronic administration ( 2 x 40 mg for 10 days ) , significant differences were observed between the kinetic parameters of the two enantiomers , the l-form of fenfluramine and norfenfluramine accumulating in plasms more than the d-forms . | NA | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
177,
189
]
} | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
194,
209
]
} |
the plasma concentrations of the aminopyrine metabolite 4-aminoantipyrine were reduced in skf 525-a treated animals while they were slightly increased in those pretreated with osa . | NA | {
"id": "C0002586",
"name": "aminopyrine",
"pos": [
33,
44
]
} | {
"id": "C0002696",
"name": "aminoantipyrine",
"pos": [
58,
73
]
} |
helper t cells of two different specificities are implicated in their optimal activation , one recognizing the idiotype and the other , an epitope on the hel molecule opposite to the one recognized by b cells . | NA | {
"id": "C0021013",
"name": "idiotype",
"pos": [
111,
119
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
139,
146
]
} |
whereas the initial phase of the endorphin-induced rise in rt was partially attenuated by naloxone ( 5 or 20 mg/kg i.p . ) or naltrexone ( 3 mg/kg i.p . ) , the late phase was completely blocked by the prostaglandin synthetase inhibitor , indomethacin ( 15 mg/kg i.p . ) . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
90,
98
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
126,
136
]
} |
the effects of timiperone , its metabolites and related compounds on specific 3h-spiroperidol binding to dopamine receptors in the rat corpus striatum were studied to clarify the affinity of timiperone , a new butyrophenone , for the receptors and whether timiperone itself was active in vivo . | NA | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
81,
93
]
} | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
210,
223
]
} |
lisuride and two other ergolines , lergotrile and bromocriptine , and the phenothiazine , fluphenazine , all interact with spiroperidol binding sites ( dopamine receptors ) in the anterior pituitary ; | NA | {
"id": "C0023863",
"name": "lisuride",
"pos": [
0,
8
]
} | {
"id": "C0014699",
"name": "ergolines",
"pos": [
23,
32
]
} |
lisuride and two other ergolines , lergotrile and bromocriptine , and the phenothiazine , fluphenazine , all interact with spiroperidol binding sites ( dopamine receptors ) in the anterior pituitary ; | NA | {
"id": "C0014699",
"name": "ergolines",
"pos": [
23,
32
]
} | {
"id": "C0006230",
"name": "bromocriptine",
"pos": [
50,
63
]
} |
indirect systolic blood pressure ( sbp ) was monitored in male , weanling , spontaneously hypertensive rats ( shr ) maintained on water for 16 weeks ( group a ) or on captopril therapy ( 100 mg/kg/day in drinking water ) for 4 ( group b ) , 8 ( group c ) , 12 ( group d ) , 16 ( group e ) weeks . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
130,
135
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
204,
218
]
} |
in ha-966-pretreated rats no tolerance for da increase followed a lesion of the dopaminergic fibres . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
43,
45
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
80,
92
]
} |
in isolated , isometrically contracting left guinea pig atria , sanguinarine , a benzophenanthridine alkaloid from the papaveracea sanguinaria canadensis , produced a concentration-dependent positive inotropic effect . | NA | {
"id": "C1720921",
"name": "benzophenanthridine",
"pos": [
81,
100
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
101,
109
]
} |
the antistem cell activity in ats , antimacrophage serum and antiplatelet serum does not appear to be caused by antibodies against histocompatibility antigens sine bone marrow stem cells from histoincompatible c57bl and balb/c mice were also sensitive to antisera against cba mouse hemopoietic cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
112,
122
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
255,
263
]
} |
and so it seems to be unlikely that the increased provable serum immune complexes by psoriatics contain specific protein antigens. -- following to limited proteolysis of normal human epidermis , antibodies which solely are provable in sera of psoriatic patients could bind to proteolytic altered structures . | NA | {
"id": "C0020960",
"name": "serum immune",
"pos": [
59,
71
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
195,
205
]
} |
on the other hand , if treated with neuraminidase and then permitted to grow in presence of the 'fibroblast growth-promoting factor ' , mammary carcinoma cells proliferated in an organized pattern , forming one-cell-thick , fibroblast-like monolayers and ultrastructural characteristics of normal epithelial cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
154,
158
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
224,
234
]
} |
and intermediate filament protein of brain , most probably neurofilament protein , is present only in nerve cells . | NA | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
4,
33
]
} | {
"id": "C0085418",
"name": "neurofilament protein",
"pos": [
59,
80
]
} |
these results indicate that coprophagy is a factor causing an increase of the 7 alpha-dehydroxylated bile acid , deoxycholic acid ( and lithocholic acid when the animals were fed chenodeoxycholic acid ) in rabbit bile . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
113,
129
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
179,
200
]
} |
sham feeding produced an acid response corresponding to 40-68 % of the maximal acid output after pentagastrin stimulation , with no significant increase of plasma gastrin concentrations . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
97,
109
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
163,
170
]
} |
four of these 21 patients had definite clinical evidence of pancreatitis and two patients had possible pancreatic disease , but in the remainder the anomaly was not considered to be clinically relevant . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
60,
72
]
} | {
"id": "C0030286",
"name": "pancreatic disease",
"pos": [
103,
121
]
} |
to investigate the possibility of measuring urinary oxalate output instead of faecal fat excretion as an outpatient screening test for steatorrhoea , we determined 24 hour urinary oxalate and five day faecal fat excretion before and during an oral load of sodium oxalate 600 mg daily ( oxalate 4.44 mmol ) , in 32 patients with suspected malabsorption on a diet containing oxalate 30 mg ( 0.33 mmol ) , fat 50 g ( 180 mmol ) , and calcium 1 g ( 25 mmol ) . | NA | {
"id": "C0038238",
"name": "steatorrhoea",
"pos": [
135,
147
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
338,
351
]
} |
the effect of size of structural aggregates on the intensity of nitrification and nitrogenase ( nitrogen : acetylene oxidoreductase ) activity was investigated in three soils . | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
82,
93
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
117,
131
]
} |
even the cadavers at low temperature display in 3 to 5 months after death the findings whose degrees correspond to those of the cadavers at normal temperature in 4 to 7 days after death . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
9,
17
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
180,
185
]
} |
carcinoma tissues , as well as normal adult and embryonic lungs contained ceramide mono- , di- and trihexosides , globoside and hematoside as major glycolipids . | NA | {
"id": "C0007745",
"name": "ceramide",
"pos": [
74,
82
]
} | {
"id": "C0017647",
"name": "globoside",
"pos": [
114,
123
]
} |
however , enzyme i seems to consist of two isoenzymes containing four subunits of almost equal molecular weight . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
10,
16
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
43,
53
]
} |
from the seeds of the same plant , a protein was isolated which binds to the lectin described above . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
77,
83
]
} |
the biological activity of recombined choriogonadotropin in vivo as well as in vitro is markedly reduced when serine 92 is removed from the c-terminus of the alpha-subunit ( des-ser92 , lys91-alpha-native beta-subunit : 36 % residual activity in vivo ) . | NA | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
38,
56
]
} | {
"id": "C0017963",
"name": "alpha",
"pos": [
192,
197
]
} |
other chromosome studies suggest anomalies of chromosome 13 in tumor tissue even in cases not showing an anomaly of this chromosome in blood cultures , and possibly a slightly increased chromosome instability . | NA | {
"id": "C0008626",
"name": "anomaly of",
"pos": [
105,
115
]
} | {
"id": "C1257806",
"name": "chromosome instability",
"pos": [
186,
208
]
} |
the frequency of sister chromatid exchanges ( sces ) was studied in cells from three freshly established lymphoma lines , derived from two patients with hodgkin 's disease and one patient with non-hodgkin lymphoma . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
105,
113
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
153,
171
]
} |
the frequency of sister chromatid exchanges ( sces ) was studied in cells from three freshly established lymphoma lines , derived from two patients with hodgkin 's disease and one patient with non-hodgkin lymphoma . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
105,
113
]
} | {
"id": "C0024305",
"name": "non-hodgkin lymphoma",
"pos": [
193,
213
]
} |
hamster bhk cells or secondary cultures of mouse embryo fibroblasts are not iodinated by lactoperoxidase in the absence of hydrogen peroxide . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} |
the isotonic and isometric tonic contractions of portal vein in response to adrenaline , noradrenaline and phenylephrine ( 0,1-1 mumol/l ) disappeared almost completely after addition of buphenin in equimolar concentrations , whereas acetylcholine contractions persisted . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
76,
86
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
89,
102
]
} |
the serum enzyme from the normal rats showed the existence of two isozymes on polyacrylamide gels which could be resolved through column chromatography . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
10,
16
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
66,
74
]
} |
though most of the metallic ions are spermicidal in action , the present investigation emphasises the spermicidal activity of anions . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
28,
32
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
126,
132
]
} |
intracerebroventricular administration of adrenaline , noradrenaline phenylephrine , clonidine and histamine produced a significant rise in plasma cortisol concentration whereas isoprenaline had no effect . alpha-adrenoceptor blockers ( yohimbine or piperoxon ) per se did not alter the plasma cortisol level . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
42,
52
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
55,
68
]
} |
the culture fluids from both glucose- and sucrose-grown organisms contained detectable amounts of serotype c antigen , whereas glucose-grown cultures also contained significant amounts of an extracellular hexose-containing polymer . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
29,
36
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
205,
211
]
} |
in cattle infected with t. vivax , the suppression of immune responses to both bacterial immunogens was abrogated when the animals were treated with berenil at the time of antigen administration . | NA | {
"id": "C0003321",
"name": "bacterial immunogens",
"pos": [
79,
99
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
172,
179
]
} |
the naf 50 % inhibition dose values for the effect of fluoride on the metabolism of glucose , sucrose , and fructose were calculated for the four dilution rates at four ph values . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
4,
7
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
54,
62
]
} |
galactose oxidase-induced interferon appeared to be immune interferon on the basis of acid lability , lack of neutralization by antibody to leukocyte interferon , and slow kinetics of activation of the cellular antiviral state . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
26,
36
]
} | {
"id": "C0021745",
"name": "immune interferon",
"pos": [
52,
69
]
} |
further analysis of the membrane proteins by sodium dodecyl sulfate-polyacrylamide gradient gel electrophoresis demonstrated that there were proteins unique to a particular phase of growth as well as differences in the amount of specific proteins from the various growth phases . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
24,
41
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
238,
246
]
} |
treated growth medium from l. donovani , on the other hand , contains both the albumin complex and a smaller molecule ( less than 27,000 molecular weight ) that is not associated with rabbit protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
79,
86
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
191,
198
]
} |
the protein-free ef of l. tropica differs from that released by trichloroacetic acid extraction in that it is capable of precipitating antisera of nonhomologous serotypes , whereas the albumin complex and the trichloroacetic acid-treated ef fragment are not . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
185,
192
]
} |
when adenine-containing compounds were used , the relative effectiveness was determined to be adenosine tetraphosphate greater than adenosine triphosphate greater than adenosine diphosphate greater than adenosine monophosphate . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
94,
103
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
132,
154
]
} |
when adenine-containing compounds were used , the relative effectiveness was determined to be adenosine tetraphosphate greater than adenosine triphosphate greater than adenosine diphosphate greater than adenosine monophosphate . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
94,
103
]
} | {
"id": "C0001465",
"name": "adenosine",
"pos": [
203,
212
]
} |
the successful serial cultivation of cervical epithelial cells , hce , depends upon the presence of a non-dividing fibroblast feeder layer which provides both attachment and growth factors for epithelial cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
115,
125
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
204,
209
]
} |
a variety of epstein-barr virus ( ebv ) dna-containing cell lines have been tested for the expression of the ebv-associated antigens ebna ( nuclear antigen ) , ea ( early antigen ) , and vca ( viral capsid antigen ) , and for the presence of cells containing disproportionate amounts of ebv dna . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
140,
155
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
206,
213
]
} |
a variety of epstein-barr virus ( ebv ) dna-containing cell lines have been tested for the expression of the ebv-associated antigens ebna ( nuclear antigen ) , ea ( early antigen ) , and vca ( viral capsid antigen ) , and for the presence of cells containing disproportionate amounts of ebv dna . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
124,
131
]
} | {
"id": "C0003342",
"name": "viral",
"pos": [
193,
198
]
} |
the laminae were removed from the lower lumbar spines of five cadavers within four hours of death . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
62,
70
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
92,
97
]
} |
the reduction of plasma cholesterol was apparently due not only to a decrease in ldl , as expressed from a marked reduction ( 15 % ) of the major ldl apolipoprotein moiety , apolipoprotein b , but also presumably to a decrease in vldl as reflected from a marked reduction ( 45 % , p less than 0.05 ) in plasma triglycerides . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
150,
164
]
} | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
174,
190
]
} |
furthermore , a marked favourable increase ( 28 % , p less than 0.001 ) in hdl major apolipoprotein moiety , apolipoprotein a , was observed . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
85,
99
]
} | {
"id": "C0003592",
"name": "apolipoprotein a",
"pos": [
109,
125
]
} |
a small decrease in blood glucose , iri and glucose/iri ratio being unaffected , a significantly two-fold greater decrease of serum cholesterol ; | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
17,
33
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
44,
51
]
} |
insulin resistance , as it occurs in obese or obese-diabetic humans and animals , is most often associated with hyperinsulinemia , and is characterized not only by increased activity of key-enzymes of pathways known to be stimulated by insulin ( glycolysis , lipogenesis ) , with the possible exception of glycogen synthesis , but also by a trend towards increased activity of key-enzymes of 'catabolic pathways ' , normally depressed by insulin . | NA | {
"id": "C0021655",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
112,
128
]
} |
the subcellular localizations of tryrosine hydroxylase ( th ) , dopamine-beta-hydroxylase ( dbh ) and phenylethanolamine-n-methyltransferase ( pnmt ) in the adrenal glands of the frog and rat have been examined by a peroxidase-antiperoxidase ( pap ) method . | NA | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
43,
54
]
} | {
"id": "C0013032",
"name": "dopamine-beta-hydroxylase",
"pos": [
64,
89
]
} |
th was localized in the ground substance of the adrenaline-containing cells and noradrenaline-containing cells , but not in the nucleus or in the mitochondria . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
48,
58
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
80,
93
]
} |
the negative reactions to th- , dbh- , and pnmt-antiserum exhibited by the summer cells of the frog adrenals prove that they belong to the cortical cells . | NA | {
"id": "C0020364",
"name": "th",
"pos": [
0,
2
]
} | {
"id": "C0013032",
"name": "dbh",
"pos": [
32,
35
]
} |
the high response of our isolate of streptomyces griseoviridus was exploited to provoke the synthesis of new viridogrisein homologues by adding various amino acids to the culture medium in an attempt to replace the alanine , sarcosine , leucine and phenylsarcosine moieties of virdogrisein . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
152,
157
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
215,
222
]
} |
samples of mer were found to contain approximately 40 % protein and/or peptide , 3 % soluble lipids , 17 % bound lipids , 8 % elemental nitrogen , and less than 2 % mycolic acids . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
126,
135
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
136,
144
]
} |
amino acid analysis showed the presence of alanine , glycine and glutamic acid as the major amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
43,
50
]
} |
amino acid analysis showed the presence of alanine , glycine and glutamic acid as the major amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
53,
60
]
} |
amino acid analysis showed the presence of alanine , glycine and glutamic acid as the major amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0815040",
"name": "acid",
"pos": [
98,
102
]
} |
the activity of ly 127935 against staphylococcus aureus , streptococcus pneumoniae , streptococcus pyogenes , streptococcus viridans and streptococcus bovis was similar to that of cephalexin and cephradine . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
180,
190
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
195,
205
]
} |
mechanism of action of the anthracycline anti-tumor antibiotics , doxorubicin , daunomycin and rubidazone : preferential inhibition of dna polymerase alpha . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
66,
77
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
80,
90
]
} |
1-n- ( 1,3-dihydroxy-2-propyl ) kanamycin b was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin b and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
91,
105
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
197,
207
]
} |
two chemical degradations of clavulanic acid are described which are useful for locating label in 14c-clavulanate . | NA | {
"id": "C0055860",
"name": "clavulanic acid",
"pos": [
29,
44
]
} | {
"id": "C0110038",
"name": "clavulanate",
"pos": [
102,
113
]
} |
neoviridogrisein ii is a homologue of viridogrisein in which the hydroxyproline residue is replaced by proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
65,
79
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
103,
110
]
} |
the analog can be purified by selective binding to cationic and anionic ion exchange resins . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
51,
59
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
72,
75
]
} |
if the bactericidal concentrations with 3-hour or 6-hour exposure to antibiotics were used as the criterion , these concentrations of carbenicillin for p. aeruginosa , and benzylpenicillin for alpha-streptococcus were , in particular , unusually high compared with the conventionally determined bacteriostatic concentrations ( mics ) . | NA | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
134,
147
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
172,
188
]
} |
the immunological cross-reaction among sulfocephalosporins ( cefsulodin , sfc-i , sfc-ii ) , cephaloridine , sulbenicillin , penicillin g and 7-aminocephalosporanic acid has been investigated . | NA | {
"id": "C0038666",
"name": "sulbenicillin",
"pos": [
109,
122
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
125,
137
]
} |
a cross-reaction was claraly demonstrated between sulfocephalosporins and sulbenicillin , but not between sulfocephalosporins and cephaloridine , penicillin g or 7-aminocephalosporanic acid . | NA | {
"id": "C0038666",
"name": "sulbenicillin",
"pos": [
74,
87
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
146,
158
]
} |
the ability to cause charge reversal of liposomes prepared from phosphatidyl inositol was ranked in the order neomycin greater than gentamicin greater than tobramycin greater than amikacin greater than kanamycin greater than ribostamycin greater than streptomycin greater than dihydrostreptomycin greater than ca2+ . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
110,
118
]
} | {
"id": "C0035554",
"name": "ribostamycin",
"pos": [
225,
237
]
} |
the ability to cause charge reversal of liposomes prepared from phosphatidyl inositol was ranked in the order neomycin greater than gentamicin greater than tobramycin greater than amikacin greater than kanamycin greater than ribostamycin greater than streptomycin greater than dihydrostreptomycin greater than ca2+ . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
180,
188
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
202,
211
]
} |
a method for the determination of aflatoxin b1 in eggs was applicable for aflatoxin b1 in liver , but ineffective for aflatoxin m1 in liver because of poor recovery of added aflatoxin and interferences in thin layer chromatography . | NA | {
"id": "C0085181",
"name": "aflatoxin m1",
"pos": [
118,
130
]
} | {
"id": "C0001734",
"name": "aflatoxin",
"pos": [
174,
183
]
} |
the chloroform phase remaining is treated with 0.1n h2so4 , and the acid extract is measured at 283 nm for the non-phenolic alkaloids , calculated as emetine . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
124,
133
]
} | {
"id": "C0013974",
"name": "emetine",
"pos": [
150,
157
]
} |
whole milk samples spiked at low levels with ampicillin , cephapirin , cloxacillin , and penicillin g were sent frozen to 11 collaborating laboratories with instructions to assay them promptly according to the method provided . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
45,
55
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
89,
101
]
} |
the 6 remaining laboratories all detected levels of 0.005-0.008 microgram or unit/ml for penicillin g , ampicillin , and cephapirin and 0.05-0.08 microgram/ml for cloxacillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
89,
101
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
104,
114
]
} |
we also found that as regards combining with , and conferring calcium sensitivity on the edta-washed myosin of scallop adductor , squid mantle lc-2 could effectively replace scallop adductor edta-lc . | NA | {
"id": "C0006692",
"name": "calcium",
"pos": [
62,
69
]
} | {
"id": "C0013618",
"name": "edta",
"pos": [
191,
195
]
} |
that is , formation of a complex of tn-c with troponin-i ( tn-i ) and troponin-t ( tn-t ) modifies the molecular kinetic mechanism of the conformational change of tn-c . | NA | {
"id": "C0041199",
"name": "complex",
"pos": [
25,
32
]
} | {
"id": "C0077401",
"name": "troponin-i",
"pos": [
46,
56
]
} |
that is , formation of a complex of tn-c with troponin-i ( tn-i ) and troponin-t ( tn-t ) modifies the molecular kinetic mechanism of the conformational change of tn-c . | NA | {
"id": "C0041199",
"name": "complex",
"pos": [
25,
32
]
} | {
"id": "C0077404",
"name": "troponin-t",
"pos": [
70,
80
]
} |
interaction of lectins with proteins of the endoplasmic reticulum and golgi system of rat liver . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
15,
22
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
28,
36
]
} |
it is suggested , therefore , that the small peripheral vesicles are formed by budding of the special regions of er membrane where microsomal marker proteins such as cytochrome p-450 are excluded and the membrane proteins destined to the golgi complexes are clustered . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
149,
157
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
204,
221
]
} |
the epithelia maintain an upper surface free of spread fibroblasts and are unable to multilayer , although occasional rounded-up cells adhere to this surface . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
a remarkably sensitive , simple and selective reversed-phase high-performance liquid chromatographic ( hplc ) method has been developed , allowing , for the first time , the direct measurement of histamine , norepinephrine , octopamine , normetanephrine , dopamine , serotonin and tyramine in a single sample of plasma ( 2 ml ) , tissue ( 0.2 g ) , or urine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
208,
222
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
238,
253
]
} |
linearity and recovery for thymine , uracil , uridine , pseudouridine , orotic acid and orotidine added to urine was demonstrated over almost a 10 ( 3 ) concentration range . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
27,
34
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
37,
43
]
} |
linearity and recovery for thymine , uracil , uridine , pseudouridine , orotic acid and orotidine added to urine was demonstrated over almost a 10 ( 3 ) concentration range . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
46,
53
]
} | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
56,
69
]
} |
ultramicro method for the determination of picogram amounts of norepinephrine and epinephrine by high-performance liquid chromatography . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
63,
77
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
82,
93
]
} |
the method provided direct , rapid chromatography of phenol sulfates in crude extracts of the red alga ( polysiphonia lanosa ( 2,3-dibromo-4,5-dihydroxybenzyl alcohol 1',4-disulfate ) , of the brown alga ascophyllum nodosum ( 1,2,3,5-tetrahydroxybenzene 2,5-disulfate ) , and in rat urine ( resorcinol mono- and disulfates ) . | NA | {
"id": "C0031428",
"name": "phenol",
"pos": [
53,
59
]
} | {
"id": "C0035197",
"name": "resorcinol",
"pos": [
291,
301
]
} |
a combination of strong cation- and anion-exchange resin columns was used to remove chromatographic background of peptides , amino acids , amino sugars , and inorganic ions . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
24,
30
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
168,
172
]
} |
simultaneous determination of diazepam and its metabolies n-desmethyldiazepam , oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
30,
38
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
60,
77
]
} |
specimens are incubated with polystyrene balls armed with burro anti-hi ( b ) antiserum , and recognition antibody is visualized by addition of alkaline phosphatase-labeled anti-globulin , together with the enzyme substrate p-nitrophenyl phosphate . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
78,
87
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
106,
114
]
} |
the development of cytopathic effect in monolayers of wi-38 fibroblasts inoculated with cell suspensions derived from the two methods was used to assess virus infectivity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
88,
92
]
} |
after reversion , the strains were tested for 19 biochemical features and for susceptibility to penicillin , ampicillin and methicillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
96,
106
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
124,
135
]
} |
early diagnosis and treatment of congenital choanal atresia can prevent death from asphyxia during the neonatal period , but after surgical correction of the atresia the possible existence of additional anomalies has to be determined and treated . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
72,
77
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
83,
91
]
} |
the continued use of chlorinated hydrocarbons as pesticides prompted an investigation into the effects of ddt ( dichlorodiphenyltrichloroethane ) on the blood of the crowned guinea-fowl ( numida meleagris ) . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
21,
45
]
} | {
"id": "C0011041",
"name": "dichlorodiphenyltrichloroethane",
"pos": [
112,
143
]
} |
the biosynthetic activities of the cells in this zone fall sharply with their distance from the zone of flattened chondrocytes . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
114,
126
]
} |
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