text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
metastases were found in 10 of 38 ( 26.3 % ) patients with breast cancer , in 5 of 17 ( 29.4 % ) patients with lung cancer , in 5 of 10 ( 50 % ) patients with cancer of the prostate , in 1 patient with rhabdomyosarcoma , 1 with chordoma and in 2 of 14 patients who underwent biopsy in search of unknown cancer . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
0,
10
]
} | {
"id": "C0027667",
"name": "unknown cancer",
"pos": [
295,
309
]
} |
in 56 samples of amniotic fluid collected during the third trimester from preeclamptic pregnancies pi/s and pg/s ratios after 36-37 weeks were comparable with those of normal pregnancies . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
53,
68
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
175,
186
]
} |
besides new syndromes are detected or separated from old diseases according to the development of the diagnostic tools . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
12,
21
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
57,
65
]
} |
postoperative survival time and recurrence-free intervals in 116 consecutive patients with supratentorial grade iii and iv gliomas ( glioblastomas , gliosarcomas , anaplastic astrocytomas , and ependymomas ) were compared in unselected groups receiving different forms of treatment . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
123,
130
]
} | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
194,
205
]
} |
these stains included nicotinamide adenine dinucleotide-tetrazolium reductase ( nadh-tr ) , succinate dehydrogenase ( sdh ) , pas , pas-diastase , myophosphorylase , calcium-mediated adenosine triphosphatase ( atpase ) preincubated at high and low ph , and oil red o . | NA | {
"id": "C0001476",
"name": "calcium",
"pos": [
166,
173
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
210,
216
]
} |
the 5-year survival was 15 % in patients with adenocarcinoma and 70 % in those with carcinoid ( p less than 0.01 by chi 2 test ) . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
46,
60
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
84,
93
]
} |
in 54 patients with thymoma , the factors having the greatest bearing on prognosis were presence or absence of gross tumor invasion or an associated clinical syndrome of myasthenia gravis , anemia due to erythrocytic hypoplasia or hypogammaglobulinemia . | NA | {
"id": "C0002871",
"name": "anemia",
"pos": [
190,
196
]
} | {
"id": "C0034902",
"name": "erythrocytic hypoplasia",
"pos": [
204,
227
]
} |
the synthesizing enzymes of tyrosine hydroxylase , tryptophan hydroxylase , dopa decarboxylase and 5-hydroxytryptophan decarboxylase are diminished in old age . | NA | {
"id": "C0003806",
"name": "dopa",
"pos": [
76,
80
]
} | {
"id": "C1412028",
"name": "5-hydroxytryptophan decarboxylase",
"pos": [
99,
132
]
} |
sensitive substrates for human leukocyte and porcine pancreatic elastase : a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
53,
72
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
166,
182
]
} |
spontaneous contractions of the adult rabbit isolated testicular capsule were found to be influenced by moderate hyperthermic and hypothermic temperature changes . | NA | {
"id": "C0015967",
"name": "hyperthermic",
"pos": [
113,
125
]
} | {
"id": "C0005904",
"name": "temperature",
"pos": [
142,
153
]
} |
spontaneous contractions of the adult rabbit isolated testicular capsule were found to be influenced by moderate hyperthermic and hypothermic temperature changes . | NA | {
"id": "C0020672",
"name": "hypothermic",
"pos": [
130,
141
]
} | {
"id": "C0005904",
"name": "temperature",
"pos": [
142,
153
]
} |
within the left ventricular cavity , at the site of maximal systolic left ventricular pressure , either there was no systolic murmur , or the murmur was of low intensity . | NA | {
"id": "C0232257",
"name": "systolic murmur",
"pos": [
117,
132
]
} | {
"id": "C0018808",
"name": "murmur",
"pos": [
142,
148
]
} |
electrocardiographic monitoring of 52 consecutive patients undergoing upper gastrointestinal endoscopy revealed that arrhythmias during the procedures were common ( 38.5 % ) and tended to occur more frequently in the elderly ( 75 % ) , in persons with heart disease ( 54.5 % ) , and in persons with chronic lung disease ( 89 % ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
117,
128
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
252,
265
]
} |
when mouse spleen cells were stimulated by irradiated allogeneic cells in a mixed lymphocyte culture for 96 hours , allospecific suppressor cells were generated that could inhibit the replicative processes when transferred to another mlr . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
54,
70
]
} |
slight modifications of the molecule , as the rupture of the beta lactam ring of the penicillin , occuring in vivo , lead to a metabolite , e.g . penicilloyl group , that has lost all antibiotic activity but possesses allergenic potential . | NA | {
"id": "C0282215",
"name": "beta",
"pos": [
61,
65
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
85,
95
]
} |
when wistar and sprague-dawley rats fed from weaning on a vitamin a and provitamin a deficient diet are supplemented with retinoic acid , they mature into adults whose general physical conditions and weight are comparable with those of retinol supplemented animals . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
58,
67
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
122,
135
]
} |
the same applies to the extent of parasitism : the average number of adult worms is higher when parasitosis occurs in males . | NA | {
"id": "C0018889",
"name": "worms",
"pos": [
75,
80
]
} | {
"id": "C0030499",
"name": "parasitosis",
"pos": [
96,
107
]
} |
an enzyme multiplied immunoassay technique is compared with a gas-liquid chromatographic technique for the measurement in blood serum of the anticonvulsants phenytoin , carbamazepine , phenobarbitone , primidone , and ethosuximide . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
185,
199
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
202,
211
]
} |
degeneration of the nigrostriatal dopaminergic system is evidenced by low levels of tyrosine hydroxylase , dopamine , homovanillic acid , and l-dopa decarboxylase in postmortem brain samples . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
34,
46
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
107,
115
]
} |
two epileptic patients developed an acute toxic encephalopathy consisting of altered behavior , deteriorating seizure control , and confusion while taking sodium valproate alone . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
4,
13
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
110,
117
]
} |
the superiority of cefoperazone over cefazolin and cefamandole with respect to activity against p. aeruginosa by more than 200-fold was especially remarkable . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
19,
31
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
51,
62
]
} |
the pharmacokinetic properties of piperacillin , a piperazine derivative of ampicillin , were determined in seven patients with creatinine clearances less than 7 ml/min who were undergoing chronic , intermittent hemodialysis . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
34,
46
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
76,
86
]
} |
gentamicin-resistant clinical isolates were usually resistant to win 42122-2 , although it was active against certain gentamicin-resistant organisms , depending upon the aminoglycoside-modifying enzymes harbored by the organism . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
0,
10
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
170,
184
]
} |
this series of antibacterial determinations and toxicity evaluations indicated that the reduced toxicity of the antibiotic may be sufficient to provide an improved therapeutic ratio over gentamicin and other aminoglycosides , even though win 42122-2 is less potent than gentamicin against some bacteria . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
187,
197
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
208,
223
]
} |
these mutants also possessed increased resistance to mecillinam but not to benzylpenicillin , ampicillin , and cephaloridine . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
75,
91
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
94,
104
]
} |
ly127935 and cefotaxime at 16 micrograms/ml inhibited 71 % of pseudomonas isolates , whereas the aminoglycosides gentamicin , tobramycin , and amikacin at a concentration of 4 micrograms/ml inhibited 84 , 88 , and 93 % , respectively . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
97,
112
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
113,
123
]
} |
the toxicity of pb was potentiated under acidic conditions ( ph 5 and 6 ) , and phosphate or carbonate anions reduced the toxicity , apparently as a result of the formation of sparingly soluble pb salts . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
80,
89
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
103,
109
]
} |
the biodegradation of three synthetic 14c-labeled polymers , poly ( methyl methacrylate ) , phenol formaldehyde , and polystyrene , was studied with 17 species of fungi in axenic cultures , five groups of soil invertebrates , and a variety of mixed microbial communities including sludges , soils , manures , garbages , and decaying plastics . | NA | {
"id": "C0032604",
"name": "polystyrene",
"pos": [
118,
129
]
} | {
"id": "C0032167",
"name": "plastics",
"pos": [
333,
341
]
} |
the results indicated that antibiotics , parathion , diazinon , aldrin , and the aflatoxins were not detected , whereas , metals , chlorinated hydrocarbon pesticides ( except aldrin ) , and pcbs were continually present . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbon",
"pos": [
131,
154
]
} | {
"id": "C0002011",
"name": "aldrin",
"pos": [
175,
181
]
} |
in addition to retinol and rbp , the study determined changes in serum carotene , proteins , albumin and globulins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
82,
90
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
93,
100
]
} |
in addition to retinol and rbp , the study determined changes in serum carotene , proteins , albumin and globulins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
82,
90
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
105,
114
]
} |
highly suitable precursors to dna synthesis for tritium labelling are 3h-thymidine , which is incorporated in excess of 3h-thymine by a factor of 255 , as well as 3h-uracil , with its activity being recovered also from the pyrimidine bases of dna via pyrimidine biosynthesis . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
123,
130
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
166,
172
]
} |
the presence of the first component of the classical pathway of complement activation ( c1q ) in the glomerular deposits and the antitreponemal antibodies in circulating cryoglobulins ( titre 1 : 320 ) support the hypothesis that immune complexes are responsbile for the glomerulonephritis in congenital syphilis . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
144,
154
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
230,
246
]
} |
removal of ammonia by means of a gas membrane is considered to be feasible and has the possibility of being used for maintenance hemodialysis in combination with urease and charcoal . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
11,
18
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
33,
36
]
} |
[ quantitative determination of protein , albumin , and antibiotics in the nasal secretions of patients with acute sinusitis ( author 's transl ) ] . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
32,
39
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
42,
49
]
} |
the amount of nasal secretions collected as well as the protein and albumin content remains fairly constant during the experiment . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
68,
75
]
} |
[ quantitative determination of protein , albumin , and antibiotics in nasal secretions of healthy probands ( author 's transl ) ] . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
32,
39
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
42,
49
]
} |
regarding all persons , the protein content and albumin ( fig . 4 ) remain constant during the experiment from 8 a.m. to 4 p.m . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
48,
55
]
} |
in the serum the maximum of the mean values plotted against the time of 2.7 microgram/ml is to be found at 2 h , if ampicillin is given , whereas the maximum of 9.3 microgram/ml is reached at 1 h after bacampicillin administration . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
116,
126
]
} | {
"id": "C0052865",
"name": "administration",
"pos": [
216,
230
]
} |
the diagnosis , natural history and management of this uncommon manifestation of cns lupus is discussed , as well as the influence of pregnancy on disease activity in sle . | NA | {
"id": "C0752332",
"name": "cns lupus",
"pos": [
81,
90
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
167,
170
]
} |
modification of the clq.sp and the raji cell ria by use of monospecific antisera to immunoglobulins g , a and m enabled the class of antibody in the immune complexes to be determined . | NA | {
"id": "C0020852",
"name": "immunoglobulins g",
"pos": [
84,
101
]
} | {
"id": "C0021017",
"name": "class",
"pos": [
124,
129
]
} |
the effect of right atrial pacing at incremental rates beginning 10 bpm above the rate of the tachycardia was studied in five patients with ventricular tachycardia , and in four patients with supraventricular tachycardia with rate-related bundle branch block aberration , the mechanism of tachycardia having been demonstrated at electrophysiology study . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
140,
163
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
289,
300
]
} |
the effect of right atrial pacing at incremental rates beginning 10 bpm above the rate of the tachycardia was studied in five patients with ventricular tachycardia , and in four patients with supraventricular tachycardia with rate-related bundle branch block aberration , the mechanism of tachycardia having been demonstrated at electrophysiology study . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
192,
220
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
289,
300
]
} |
nalidixic acid may cause severe acidosis and we report a fatal case of lactic acidosis assocaited with nalidixic acid therapy . | NA | {
"id": "C0001122",
"name": "acidosis",
"pos": [
32,
40
]
} | {
"id": "C0001125",
"name": "lactic",
"pos": [
71,
77
]
} |
nine cases in which subcutaneous rheumatoid nodules were observed in the absence of any evidence of rheumatoid arthritis are recorded . | NA | {
"id": "C0035450",
"name": "subcutaneous rheumatoid nodules",
"pos": [
20,
51
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
100,
120
]
} |
2009 faecal samples were found to contain 19 cases of liver fluke infestation ( 0.94 % ) , 1648 cases of hook and round worms ( 82.03 % ) , 162 cases of type worms ( 8.06 % ) , and 964 cases of coccidiosis ( 47.98 % ) . | NA | {
"id": "C0027583",
"name": "round worms",
"pos": [
114,
125
]
} | {
"id": "C0018889",
"name": "worms",
"pos": [
158,
163
]
} |
the etiologic agent of this disease has not yet been isolated , but a close etiologic relation between korean hemorrhagic fever and epidemic hemorrhagic fever in japan has been suspected because of similarities in the clinical and pathological pictures of the two diseases . | NA | {
"id": "C0012634",
"name": "disease",
"pos": [
28,
35
]
} | {
"id": "C0030660",
"name": "pathological",
"pos": [
231,
243
]
} |
metabolism of gold in the rat following a single administration of sodium aurothiomalate : mathematical analysis of serum and organ concentrations . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
14,
18
]
} | {
"id": "C0018034",
"name": "sodium",
"pos": [
67,
73
]
} |
these results suggest that sigma st and nst at the end of evolution of myocardial infarction or 48 hours after the onset may be two useful indices for the assessment of infarct size in patients with either anterior or inferior myocardial infarction . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
71,
92
]
} | {
"id": "C0340305",
"name": "inferior myocardial infarction",
"pos": [
218,
248
]
} |
the clinical and histological picture showed transitions , which ranged from lichen planus and lichenoid poikilodermatous syndromes to dermatitis . | NA | {
"id": "C0023646",
"name": "lichen planus",
"pos": [
77,
90
]
} | {
"id": "C0162848",
"name": "lichenoid",
"pos": [
95,
104
]
} |
the amino acid composition of this glycoprotein showed 62 mol % hydrophobic residues , while the acidic amino acid content contributed 9 mol % more than that of the basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0815040",
"name": "acidic amino acid",
"pos": [
97,
114
]
} |
the amino acid composition of this glycoprotein showed 62 mol % hydrophobic residues , while the acidic amino acid content contributed 9 mol % more than that of the basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0301714",
"name": "basic amino",
"pos": [
165,
176
]
} |
except for l1 and l2 proteins , each of the ribosomal proteins , including less basic ones , showed a major radioactive peak coinciding with the protein band on sds gel . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
44,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
145,
152
]
} |
albumin and alpha-fetoprotein were measured by radioimmunoassay of serum concentration , immunofluorescence , and in vitro incorporation of labeled amino acids into proteins specifically precipitated by antisera . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
0,
7
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
165,
173
]
} |
the amount of albumin and alpha-fetoprotein produced by the different tissues is directly related to the number of functional mrna molecules per cell for each protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
14,
21
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
159,
166
]
} |
during this period rrna was shown to decay linearly , taking about 41 h for half of this rna to disappear . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
19,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
89,
92
]
} |
by this method , we demonstrated that albumin synthesizing polyribosomes from a serum albumin secreting mouse hepatoma cell line exist over a broad range from trimers to 20-mers ( mean 6-10 ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
38,
45
]
} | {
"id": "C0036773",
"name": "albumin",
"pos": [
86,
93
]
} |
the pairing of the four intrachain disulfide bonds of bovine seminal ribonuclease , a dimeric protein isolated from bovine seminal plasma , has been established by the isolation and characterization of the cystine peptides obtained from a thermolytic-tryptic hydrolysate of the protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
94,
101
]
} | {
"id": "C0033631",
"name": "hydrolysate",
"pos": [
259,
270
]
} |
these findings give support to the assumption that the binding site for warfarin on the albumin molecule is affected by the neutral-to-base transition in the protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
88,
95
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} |
[ submitochondrial localization of the reaction in the transformation from corticosterone to 18-hydroxycorticosterone and to aldosterone ] . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
75,
89
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
93,
117
]
} |
this tumor is thought to reflect a neoplastic transformation of the pulmonary apud cells because of the morphological similarities with k-cells , the association with paraneoplastic syndromes and the high incidence of ectopic hormone production . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
5,
10
]
} | {
"id": "C0030472",
"name": "paraneoplastic",
"pos": [
167,
181
]
} |
the immunization of rabbits with the serologically active product gave rise to an antiserum containing two kinds of antibodies : anti-hla-a9 and anti-alpha 1-microglobulin . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
82,
91
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
116,
126
]
} |
both cells contain and/or produce a large variety of acid and neutral hydrolases including representatives of all four classes of tissue proteinases . | NA | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
70,
80
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
137,
148
]
} |
in 12 patients whose neurological dysfunction was associated with thrombocytosis or evidence of abnormal platelet activation , or both , correction of the platelet disorder corresponded with reversal of the neurological symptoms . | NA | {
"id": "C0836924",
"name": "thrombocytosis",
"pos": [
66,
80
]
} | {
"id": "C0005818",
"name": "platelet",
"pos": [
155,
163
]
} |
the effects of an apple-supplemented diet on plasma and liver cholesterol were investigated in two strains of hamster , a normal one and another which exhibits a spontaneous accumulation of cholesteryl esters in the liver ( fec animals ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
62,
73
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
190,
208
]
} |
besides the three oligopeptides mentioned , four peptides , l-phe-l-phe , l-phe-l-phe-l-phe , l-tyr-l-tyr and l-tyr-l-tyr-ltyr , still showed a weak inhibitory effect on the tan in a high concentration . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
18,
31
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
49,
57
]
} |
sulfur isotope fractionation by salmonella heidelberg : inverse isotope effects during growth on high concentrations of na2so3 . | NA | {
"id": "C0038780",
"name": "sulfur isotope",
"pos": [
0,
14
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
64,
71
]
} |
during growth in the presence of 0.5-1.5 % alpha-aminobutyrate , both organisms accumulated high concentrations of isoleucine ( 100-225 microgram/ml ) while the normal accumulation of valine was unaffected . alpha-ketobutyrate , a product of alpha-aminobutyrate metabolism , also stimulated isoleucine excretion by these organisms . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
262,
272
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
302,
311
]
} |
a mesophilic anaerobe , a member of the bacteroidaceae family ( nrc2248 ) , isolated from a cellulose-enrichment culture , digested untreated whatman cellulose powder and hcl-treated cotton battings while producing hydrogen , carbon dioxide , cellobiose , glucose , and acetic acid as the sole volatile acid . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
92,
101
]
} | {
"id": "C0789987",
"name": "cellulose powder",
"pos": [
150,
166
]
} |
a mesophilic anaerobe , a member of the bacteroidaceae family ( nrc2248 ) , isolated from a cellulose-enrichment culture , digested untreated whatman cellulose powder and hcl-treated cotton battings while producing hydrogen , carbon dioxide , cellobiose , glucose , and acetic acid as the sole volatile acid . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
92,
101
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
243,
253
]
} |
because mcs are absent from adult rabbit leptomeninges but present in the rat , it was concluded that the mc-like elements in rabbit cultures were derived from precursor cells normally capable of producing nlms . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
160,
175
]
} | {
"id": "C0007634",
"name": "nlms",
"pos": [
206,
210
]
} |
several 2,5-disubstituted furans , which are known to react with peroxyacids , singlet oxygen and other active forms of oxygen were tested as potential inhibitors , co-oxidants , or substrates for soybean lipoxygenase . | NA | {
"id": "C0074565",
"name": "singlet oxygen",
"pos": [
79,
93
]
} | {
"id": "C0162772",
"name": "active",
"pos": [
104,
110
]
} |
described herein are chemical syntheses of 3 alpha-benzoyloxy-5 alpha-cholest-8 ( 14 ) -en-15-one , 5 alpha-cholest-8 ( 14 ) -en-3 alpha-ol-15-one , 5 alpha-cholest-8 ( 14 ) -en-15-one-3 beta-yl pyridinium sulfate , 5 alpha-cholest-8 ( 14 ) -en-15-one-3 beta-yl potassium sulfate ( monohydrate ) , 5 alpha-cholest-8 ( 14 ) -en-15-one-3 alpha-yl pyridinium sulfate , 5 alpha-cholest-8 ( 14 ) -en-3 alpha-yl potassium sulfate ( monohydrate ) , 5 alpha-cholest-8 ( 14 ) -en3,7,15-trione , 5 alpha-cholest-8 ( 14 ) -en-15 alpha-ol-3-one , 5 alpha , 14 alpha-cholestan-3 beta , 15 beta-diol diacetate , 5 alpha , 14 beta-cholestan-3 beta , 15 beta-diol diacetate , 5 alpha , 14 alpha-cholestan-3 beta , 15 alpha-diol , 5 alpha , 14 alpha-cholestan-15 alpha-ol-3-one , 5 alpha , 14 beta-cholestan-3 beta , 15 beta-diol , 5 alpha , 14 alpha-cholestan-3,15-dione , and 5 alpha , 14 beta-cholestan-3,5-dione . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
206,
213
]
} | {
"id": "C0071780",
"name": "potassium sulfate",
"pos": [
406,
423
]
} |
conversely there was a high incidence ( 65 % ) of bone structure reshuffling , signally osteoporosis , probably imputable to steatorrhea and vitamin d malabsorption , plus the often associated increase of serum alkaline phosphatase activity . | NA | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
125,
136
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
151,
164
]
} |
the retinoids , including natural vitamin a compounds and their synthetic analogs , present a new class of substances exerting a prophylactic and a therapeutic effect both in certain experimental tumor models and in certain clinical conditions of preneoplastic and neoplastic lesions . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
4,
13
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
34,
43
]
} |
the tissue distribution of 4-demethoxydaunorubicin and 4-demethoxydoxorubicin was studied in comparison with that of their patient compounds , daunorubicin and doxorubicin , in mice bearing transplanted tumors . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
38,
50
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
160,
171
]
} |
after administration of equal doses of daunorubicin and 4-demethoxydaunorubicin , the calculated cxt values of 4-demethoxydaunorubicin equivalents were higher than those for daunorubicin in all the organs tested except the heart . | NA | {
"id": "C0020789",
"name": "4-demethoxydaunorubicin",
"pos": [
56,
79
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
174,
186
]
} |
optimal binding was achieved in 2 hours at 25 degrees c for concanavalin a and at 4 derees c for ricinus communis agglutinin 120 and wheat germ agglutinin , and was also a function of the ratio of lectin protein to gamma-glutamyltransferase protein . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
197,
203
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
241,
248
]
} |
collectively these data indicate that the trh-induced gh rise emphasizes defects in the neurohormonal links between the central nervous system and the anterior pituitary . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
54,
56
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
151,
169
]
} |
the thirty-three patients with in vivo biopsy ana included twenty-three with sle , three with mixed connective tissue disease , two each with multi-system sjogren 's syndrome , dermatomyositis , and progressive systemic sclerosis , and one with rheumatoid arthritis . | NA | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
155,
174
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
245,
265
]
} |
the rabbits infected orally with the organism produced only the precipitins against protein antigen , and the amount of the antibody was equal to or greater than that of intravenous infection . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
64,
75
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
124,
132
]
} |
there was no correlation between cord water content or volume and several other variables including birthweight , size for gestational age and placental weight . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
100,
111
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
153,
159
]
} |
in agreement with the development stages , studied patients were divided into the group of younger children in prematurity stage and the group of older children approaching the maturity . | NA | {
"id": "C0728836",
"name": "of younger children",
"pos": [
88,
107
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
152,
160
]
} |
the results showed that in children suffering from diabetes , excretion of adrenaline was increased and that of noradrenaline decreased when compared with healthy children . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
75,
85
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
112,
125
]
} |
taking into consideration changes in the sympatho-adrenergic system activity in cases with different degrees of compensation of metabolic processes during insulinization , it should be stressed that in children with ketoacidosis , excretion of catecholamines was still different in comparison with control group . | NA | {
"id": "C0025519",
"name": "metabolic processes",
"pos": [
128,
147
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
231,
240
]
} |
essential amino acids , such as isoleucine , leucine , lysine , methionine , phenylalanine , and valine were excreted in relatively small amounts . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
0,
21
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
64,
74
]
} |
as compared to the trained men , untrained men showed statistically significantly higher concentrations in sweat for the following amino acids : alanine , arginine , glycine , histidine , isoleucine , leucine , lysine , ornithine , phenylalanine , serine , taurine , threonine , tyrosine , and valine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
131,
142
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
238,
245
]
} |
as compared to the trained men , untrained men showed statistically significantly higher concentrations in sweat for the following amino acids : alanine , arginine , glycine , histidine , isoleucine , leucine , lysine , ornithine , phenylalanine , serine , taurine , threonine , tyrosine , and valine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
131,
142
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
166,
173
]
} |
the unsuitability of blood-free perfusates compared with whole-blood perfusates in the study of chylomicron and chylomicron-remnant metabolism by the perfused liver [ proceedings ] . | NA | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
96,
107
]
} | {
"id": "C0443616",
"name": "chylomicron-remnant",
"pos": [
112,
131
]
} |
2 ) a slight but consistent elevation of blood glucose in the fasted and fed basal states and especially of blood glucose 90 min after an iv glucose load ( 2 g/kg ) performed under pentobarbitone anaesthesia ; | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
41,
54
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
141,
148
]
} |
ordering of the segments ( in relation to the gamma genetic map and with the direction from left to right corresponding to the clockwise orientation of the e. coli genetic map and to each of the numerical sequences given ) reveals , on 26 kb of bacterial dna , two cleavage sites defining the 7.5-kb segment obtainable from the dna of either gamam darg13 or gamma darg14 . | NA | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
245,
258
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
328,
331
]
} |
with concentration of these catecholamines for the equivalent positive inotropic potency on the papillary muscle , this effect of isoproterenol was more potent than the effects of dobutamine and dopamine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
28,
42
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
130,
143
]
} |
with concentration of these catecholamines for the equivalent positive inotropic potency on the papillary muscle , this effect of isoproterenol was more potent than the effects of dobutamine and dopamine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
28,
42
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
180,
190
]
} |
pharmacological effects of dobutamine ( dob ) , a positive inotropic drug , on smooth muscles were compared with those of catecholamines such as norepinephrine ( ne ) , epinephrine ( e ) , isoproterenol ( iso ) and dopamine ( da ) . | NA | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
27,
37
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
122,
136
]
} |
pharmacological effects of dobutamine ( dob ) , a positive inotropic drug , on smooth muscles were compared with those of catecholamines such as norepinephrine ( ne ) , epinephrine ( e ) , isoproterenol ( iso ) and dopamine ( da ) . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
122,
136
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
189,
202
]
} |
pharmacological effects of dobutamine ( dob ) , a positive inotropic drug , on smooth muscles were compared with those of catecholamines such as norepinephrine ( ne ) , epinephrine ( e ) , isoproterenol ( iso ) and dopamine ( da ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
145,
159
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
169,
180
]
} |
among autacoids which contract the intestine by direct action on smooth muscles , histamine and bradykinin had no cathartic effect in mice and rats . | NA | {
"id": "C0037343",
"name": "autacoids",
"pos": [
6,
15
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
82,
91
]
} |
ten adult male rats were administered orally with thyroideum siccatum every day to produce a hyperfunctional state of thyroid hormone . | NA | {
"id": "C0040134",
"name": "thyroideum siccatum",
"pos": [
50,
69
]
} | {
"id": "C0040135",
"name": "thyroid hormone",
"pos": [
118,
133
]
} |
the elongated vessels can produce so-called normal pressure hydrocephalus by impressing the floor of the third ventricle , although the hydrocephalus can not be confirmed by computer tomographic cisternography . | NA | {
"id": "C0020258",
"name": "normal pressure",
"pos": [
44,
59
]
} | {
"id": "C0020255",
"name": "hydrocephalus",
"pos": [
136,
149
]
} |
on treatment with hydrocortisone and fludrocortisone , most steroids with the exception of increased 17oh-pregnenolone in plasma and delta 5-pregnenetriol and pregnanetriol in urine , were normal . | NA | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
18,
32
]
} | {
"id": "C0016280",
"name": "fludrocortisone",
"pos": [
37,
52
]
} |
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