text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
using a biostator glucose-controlled insulin infusion system to monitor blood glucose during surgery , we have shown that both nondiabetic and diabetic patients have a tendency towards hyperglycemia during surgery . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
18,
25
]
} | {
"id": "C0005802",
"name": "blood",
"pos": [
72,
77
]
} |
the change from type i to type iii control mode effected an increase of initial insulin infusion rates ( 91 +/- 59 to 313 +/- 81 mu/min 10-20 min after glucose ingestion ) and a decrease of infusion rates during the following phase of the 3-hour observation period ( 28.2 +/- 4.2 to 18.1 +/- 2.8 u ) in patients whose blood glucose curves were completely normalized . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
152,
159
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
318,
331
]
} |
urinary excretion of norepinephrine markedly increased at the beginning of the study , reversed almost to normal during aep treatment , while minor changes were observed in urinary excretion of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
21,
35
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
194,
205
]
} |
blood glucose ( bg ) was clamped by means of the dextrose infusion unit of the artificial beta cell , and the secretion of the pancreatic beta cell was monitored by immunomeasureable c-peptide ( imcp ) before , during , and after infusion of insulin . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "dextrose",
"pos": [
49,
57
]
} |
serum-stimulated rna synthesis in starved , sv-40 transformed fibroblasts ( wi-38-va-13 cells ) was inhibited , but not completely prevented , by ams indicating that transformed cells may produce specific rna 's that are not ams-sensitive and that may be responsible for the failure of transformed cells to be arrested in g1 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
298,
303
]
} |
thermodynamics of dialysis equilibrium & excess hydration of proteins : part i -- negative binding of glycols & alcohols . | NA | {
"id": "C0017951",
"name": "glycols",
"pos": [
102,
109
]
} | {
"id": "C0001975",
"name": "alcohols",
"pos": [
112,
120
]
} |
data for x-pro-y peptides ( y = imino acid ) indicate significantly reduced values of delta beta gamma , and this appears to be a useful basis for assigning the pro c beta resonances corresponding to this sequence . | NA | {
"id": "C0020931",
"name": "imino acid",
"pos": [
32,
42
]
} | {
"id": "C0033382",
"name": "pro",
"pos": [
161,
164
]
} |
hydrogen-tritium exchange titration of the histidine residues in bovine heart cytochrome c and analysis of their microenvironment . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
0,
8
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
9,
16
]
} |
microenvironments of the three histidine residues located at the positions 18 , 26 , and 33 from the amino terminus in bovine heart cytochrome c were analysed in solution by the hydrogen-tritium exchange titration method , which has been developed in this laboratory . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
178,
186
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
187,
194
]
} |
thymopoietin32 -- 36 ( tp5 ) is a synthetic pentapeptide that has the biological activity of its parent molecule , the 49 amino acid thymic hormone thymopoietin . | NA | {
"id": "C0040114",
"name": "thymic hormone",
"pos": [
133,
147
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
148,
160
]
} |
human embryo fibroblasts treated with diethylstilbestrol ( des ) gave rise to slightly increased plaque production by cytomegalovirus ( cmv ) : plaques were also slightly larger in treated cells when compared to those in untreated cultures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
189,
194
]
} |
plasma epinephrine ( e ) and norepinephrine ( ne ) as well as blood pressure and heart rate variations were measured in 12 male subjects before , during , and after a cold hand test ( 5 degrees c for 2 min ) , a mental arithmetic test , and a combination of both these tests . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
7,
18
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
29,
43
]
} |
it is shown that a rapid change in [ hco3- ] csf occurs during the infusion of hcl or nahco3 . | NA | {
"id": "C0005367",
"name": "hco3",
"pos": [
37,
41
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
86,
92
]
} |
the bioavailability for four different commerically available brands of ampicillin compared with that of talampicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
72,
82
]
} | {
"id": "C0039266",
"name": "talampicillin",
"pos": [
105,
118
]
} |
the greater antigenicity and acceptable clinical reactivity of a vaccine containing 50 total combining power units per 0.5 mm of adsorbed toxoid resulted in its selection for further field studies . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
65,
72
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
138,
144
]
} |
the retention of norepinephrine , alpha-methylnorepinephrine , dopamine , alpha-methyldopamine , l-dopa , alpha-methyldopa , dihydroxybenzylamine , epinephrine , carbidopa and dopac was measured in mobile phases composed of nitric , sulfuric , acetic and trichloroacetic acids at ph 2-5 and anion concentrations ranging from 5-500 mm . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
17,
31
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
34,
60
]
} |
the retention of norepinephrine , alpha-methylnorepinephrine , dopamine , alpha-methyldopamine , l-dopa , alpha-methyldopa , dihydroxybenzylamine , epinephrine , carbidopa and dopac was measured in mobile phases composed of nitric , sulfuric , acetic and trichloroacetic acids at ph 2-5 and anion concentrations ranging from 5-500 mm . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
17,
31
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
148,
159
]
} |
this monooxygenase was a homogeneous protein , giving a monomeric molecular weight of 145,000 , which had neither any significant nadph diaphorase activity nor cytochrome b5-like haem protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
37,
44
]
} | {
"id": "C0018974",
"name": "haem protein",
"pos": [
179,
191
]
} |
the recoveries for several carbamates including aminocarb , mexacarbate , carbaryl , propoxur , carbofuran , pirimicarb and methiocarb were from 86 to 108 % at 1.0 and 0.01 ppm levels . | NA | {
"id": "C0006948",
"name": "carbamates",
"pos": [
27,
37
]
} | {
"id": "C0036860",
"name": "carbaryl",
"pos": [
74,
82
]
} |
estimation of two other acute-phase proteins , alpha 1-antitrypsin and orosomucoid , was not of additional diagnostic value . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
24,
44
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
47,
66
]
} |
estimation of two other acute-phase proteins , alpha 1-antitrypsin and orosomucoid , was not of additional diagnostic value . | NA | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
24,
44
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
71,
82
]
} |
the present study suggests that measurement of plasma barbiturate concentrations is of value in identifying patients at risk of developing serious intoxication after overdosage with pentobarbital or secobarbital . | NA | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
54,
65
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
182,
195
]
} |
the present study suggests that measurement of plasma barbiturate concentrations is of value in identifying patients at risk of developing serious intoxication after overdosage with pentobarbital or secobarbital . | NA | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
54,
65
]
} | {
"id": "C0036516",
"name": "secobarbital",
"pos": [
199,
211
]
} |
broken cell preparations of wi-38 and sv40-transformed wi-38 ( va13 ) fibroblasts were used to compare the cyclic nucleotide phosphodiesterase activities of the two cell strains . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
70,
81
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
157,
160
]
} |
[ study on alterations in the metabolism of catecholamines after open heart surgery -- the first report : depletion of endogeneous dopamine , noradrenaline and adrenaline ( author 's transl ) ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
142,
155
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
160,
170
]
} |
in addition , most preparations of testicular hyaluronidase caused a conversion of the cells to a fibroblastic phenotype characterized by a faster growth rate and the synthesis of type-i collagen . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
87,
92
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
98,
110
]
} |
the addition of dopamine to the visceral ganglion slowed and stopped ciliary activity by increasing the firing rate of the cilio-inhibitory dopaminergic neurones of the visceral ganglion which innervate the gill . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
16,
24
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
140,
152
]
} |
the interaction between hbsag and polymerized hsa is discussed in relation to previous findings of hsa polymers and anti-polymerized albumin antibodies in hepatic patients . | NA | {
"id": "C0304925",
"name": "hsa",
"pos": [
46,
49
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
133,
140
]
} |
the reduction of [ 99tc ] pertechnetate was studied as a function of ph in complexing media of pyrophosphate , methylene diphosphonate ( mdp ) , and ethane-1 , hydroxy-1 , and 1-diphosphonate ( hedp ) . | NA | {
"id": "C0066351",
"name": "methylene diphosphonate",
"pos": [
111,
134
]
} | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
178,
191
]
} |
these data support the conclusion that during metabolic blockade there is a significant replacement of larger intracellular anions by extracellular chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
124,
130
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
148,
156
]
} |
the extent of atp splitting during the period from 1.5 to 6.5 s after stimulation began was determined from observations of the levels of phosphocreatine , creatine and the sum of inorganic phosphate and glucose-6-phosphate and glucose-1-phosphate . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
138,
153
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
156,
164
]
} |
taken in conjunction with the results of in vitro studies on the specificity of action of dalpha ? and related substances , these observations suggest that certain synaptic excitations in the spinal cord are mediated by an excitatory amino acid transmitter , and that this transmitter interacts with receptors which are activated selectively by nmda , less selectively by other amino acids , including l-aspartate , and probably only slightly by quisqualate , kainate and ( exogenous ) l-glutamate . | NA | {
"id": "C0243046",
"name": "excitatory amino acid",
"pos": [
223,
244
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
378,
389
]
} |
trypanosoma cruzi was found to synthesize purine nucleotides only fring incorporated into both adenine and guanine nucleotides . | NA | {
"id": "C0034137",
"name": "purine nucleotides",
"pos": [
42,
60
]
} | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
107,
126
]
} |
putrescine and sperimidine synthesis occurred rapidly from ornithine : putrescine synthesis peaked in 0.5 h , spermidine in 1 h . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
0,
10
]
} | {
"id": "C0037871",
"name": "1 h",
"pos": [
124,
127
]
} |
midgut absorption of undigested albumin and other proteins by tsetse , glossina m. morsitans ( diptera : glossinidae ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
32,
39
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
50,
58
]
} |
structural interpretation of the amide proton exchange in the basic pancreatic trypsin inhibitor and related proteins . | NA | {
"id": "C0003641",
"name": "basic pancreatic",
"pos": [
62,
78
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
109,
117
]
} |
measurement of met-enk in rat brain p2 fraction revealed besides met-enk , the presence of the factor which cross-reacted with the antiserum and also appeared to bind with the brain opiate receptor . | NA | {
"id": "C0014298",
"name": "met-enk",
"pos": [
15,
22
]
} | {
"id": "C0014295",
"name": "met-enk",
"pos": [
65,
72
]
} |
the mode of actions of 5-hydroxytryptamine ( 5-ht ) and its derivatives , tryptophan ( tp ) , 5-hydroxytryptophan ( 5-htp ) and 5-hydroxyindole acetic acid ( 5-hiaa ) was studied on the isolated , blood-perfused small intestine and isolated ileum strip of rats . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
74,
84
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
116,
121
]
} |
in the isolated , blood-perfused intestinal preparations , 5-ht and 5-htp injected into the superior mesenteric artery caused a monophasic fast contraction , while tp and 5-hiaa had no effects on the intestine . | NA | {
"id": "C0000578",
"name": "5-htp",
"pos": [
68,
73
]
} | {
"id": "C0041249",
"name": "tp",
"pos": [
164,
166
]
} |
the mode of actions of the purines , adenosine , adenosine-5'-triphosphate ( atp ) , guanosine and guanosine-5'-triphosphate ( gtp ) , and the pyrimidines , cytidine , cytidine-5'-triphosphate ( ctp ) , thymidine , thymidine-5'-triphosphate ( ttp ) , uridine and uridine-5'-triphosphate ( utp ) was investigated in the isolated hindlimb preparation of the rat . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
37,
46
]
} | {
"id": "C0001480",
"name": "adenosine-5",
"pos": [
49,
60
]
} |
a single injection of adenosine , atp , gtp or utp into the femoral artery induced a biphasic response , a prominent vasoconstriction preceded by a transient vasodilatation , whereas guanosine and uridine caused only a vasoconstriction . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
22,
31
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
34,
37
]
} |
the vasoconstrictor responses to adenosine , atp , guanosine and gtp were effectively antagonized by either methysergide or reserpine , whereas those to uridine and utp were not modified by either methysergide or phentolamine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
33,
42
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
45,
48
]
} |
the following evidence was obtained : ( 1 ) the amount of cholesterol and cholesteryl ester in the atheromatous aorta were reduced after cpib treatment . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
58,
69
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
74,
91
]
} |
the effects of angiotensin ii ( ag-11 ) and 1-sar. , 8-isoleu . angiotensin 11 ( anti-ag-11 ) on the membrane and mechanical properties of smooth muscle cells of the rat portal vein were investigated in three different age groups ( 6 -- 8 weeks , immature rat ; 3 -- 5 months old , young rat and 13 -- 15 months old , adult rat ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
15,
29
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
64,
75
]
} |
the degree of heterogeneity in c57bl/6 mice was markedly higher than that in cba mice under the following conditions of immunization : immunization with tnp conjugated with bovine gamma-globulin or ovalbumin , interchange of these carrier proteins at the first and second injections , change of epitope density of the antigens , replacement of the hapten by dinitrophenyl group on the antigen for the secondary stimulation , and change of intervals of these injections from 15 days to five months . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
295,
302
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
348,
354
]
} |
the degree of heterogeneity in c57bl/6 mice was markedly higher than that in cba mice under the following conditions of immunization : immunization with tnp conjugated with bovine gamma-globulin or ovalbumin , interchange of these carrier proteins at the first and second injections , change of epitope density of the antigens , replacement of the hapten by dinitrophenyl group on the antigen for the secondary stimulation , and change of intervals of these injections from 15 days to five months . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
295,
302
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
385,
392
]
} |
the reversal immune surveillance hypothesis explains why spontaneously occurring tumours may not be antigenic , in the sense of eliciting their own destruction , and is consistent with the destruction of tumour cells that display significant amounts of viral antigens or gross antigenic changes induced by carcinogenic agents . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
253,
267
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
277,
286
]
} |
several human diseases or pathologic conditions of unknown etiology have similarities to findings in deficient animals . | NA | {
"id": "C0012634",
"name": "diseases",
"pos": [
14,
22
]
} | {
"id": "C0030660",
"name": "pathologic conditions",
"pos": [
26,
47
]
} |
within all three iron preparations a very good correlation was found between bio-availability and haematopoietic efficacy : the very good absorbability of the bivalent quick release stick capsule preparation s ( = 100 % ) corresponded with a very good capacity of haemoglobin regeneration ( 2,6 +/- 0,4 g hb/1/day ) whereas due to a very low absorbability ( 10 % to 16 % ) the antianaemic efficacy of both iron ( iii ) preparations l and x had to be rated as moderate to predominantly poor . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
305,
307
]
} |
among japanese in hawaii , rates of some of these cancers ( lymphosarcoma , cml ) approach those of whites , whereas rates of other cancers ( hodgkin 's disease , multiple myeloma , all , cll , and aml ) more closely resemble those of native japanese . | NA | {
"id": "C0024299",
"name": "lymphosarcoma",
"pos": [
60,
73
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
142,
160
]
} |
it is believed that the difference in cancer mortality of all sites between the developed and developing countries can be explained by the different levels of mortality from infectious and parasitic diseases , including deaths from tuberculosis . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
174,
184
]
} | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
189,
207
]
} |
patterns of thymocyte labeling in vitro with tritiated thymidine and deoxycytidine , with special reference to competitive incorporation of the two deoxyribonucleosides . | NA | {
"id": "C0040077",
"name": "thymidine",
"pos": [
55,
64
]
} | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
148,
168
]
} |
these data suggest that a same genetic trait can give rise to both a spontaneous hypercholesterolemia and an arterial hyperactivity against a superimposed hyperlipemia . | NA | {
"id": "C0020443",
"name": "hypercholesterolemia",
"pos": [
81,
101
]
} | {
"id": "C0020473",
"name": "hyperlipemia",
"pos": [
155,
167
]
} |
carrageenan is sulfated polysaccharide which has been extensively used as emulsifier and thickening agent in the food industry , for its ability to induce acute inflammation in pharmacology and for its selectively toxic effect for macrophages in immunology . | NA | {
"id": "C0007289",
"name": "carrageenan",
"pos": [
0,
11
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
24,
38
]
} |
the transient depolarizations in cat papillary muscle produced by chloride substitution with low mobility anions are largely due to changes in liquid-junction potential at the tissue level . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
66,
74
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
106,
112
]
} |
dna sequences homologous to the probe are detected by autoradiography , thus generating a restriction enzyme pattern of the plasmid from a digest of total bacterial dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
155,
168
]
} |
when the rna of such complexes is 32p-labelled , a simple comparison of the dna fluorogram with an autoradiogram identifies transcriptionally active dna molecules and restriction fragments in any mixture . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
11,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
149,
152
]
} |
the extent of base-pairing and the calculated stabilities of the hybrids that can be constructed between 5s rrnas and the small ribosomal subunit rnas are greater than most , if not all , rna-rna interactions that have been implicated in protein synthesis . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
108,
113
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
192,
195
]
} |
the existence of complementary sequences in 5s rrna and small ribosomal subunit rna , along with the previous observation that there is very efficient and selective hybridization in vitro between 5s and 18s rrna , suggests that base-pairing between 5s rrna in the large ribosomal subunit and 18s ( 16s ) rrna in the small ribosomal subunit might be involved in the reversible association of ribosomal subunits . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
48,
51
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
304,
308
]
} |
these results suggest an association of hormone receptor complex with nucleoprotein structures of an apparently active chromatin fraction . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
70,
83
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
119,
128
]
} |
the clinical and hormonal effects ( serum luteinizing hormone ( lh ) , follicle-stimulating hormone ( fsh ) , prolactin , progesterone , testosterone and urinary oestrogens , pregnanediol , pregnanetriol , androsterone and etiocholanolone ) were evaluated after 4 and 8 weeks of treatment . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
122,
134
]
} | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
175,
187
]
} |
the cell population of the liquid of broncho-alveolar lavage of 44 cases of mediastino-pulmonary sarcoidosis was compared to that of 12 normal controls , of 14 controls with a localized pulmonary affection , who underwent lavage in healthy contro-lateral segment , and of 33 patients with various diffuse interstitial pneumopathies , except hypersensitivity ones . | NA | {
"id": "C0036205",
"name": "pulmonary sarcoidosis",
"pos": [
87,
108
]
} | {
"id": "C0206062",
"name": "interstitial pneumopathies",
"pos": [
305,
331
]
} |
the association of lymphoedema in lower limbs , of yellow nail and other changes brought by lymphatic disorders enabled to attribute some inexhaustible pleural effusion to this syndrome which can develop in the adult , probably through the help of microtrauma or of oligosymptomatic infections . | NA | {
"id": "C0024236",
"name": "lymphoedema",
"pos": [
19,
30
]
} | {
"id": "C0024228",
"name": "lymphatic disorders",
"pos": [
92,
111
]
} |
none of the dietary treatments significantly altered body weight , egg production , egg weight , or feed consumption . | NA | {
"id": "C0005911",
"name": "altered",
"pos": [
45,
52
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
88,
94
]
} |
the so2 could not be detected in caudal thoracic or abdominal air sac gas at any concentration inhaled but vascular congestion and areas of brown discoloration appeared in the lungs of all birds that inhaled 5000 ppm and some that inhaled 1000 ppm . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
4,
7
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
70,
73
]
} |
binding of leu-enkephalin could not be displaced by a hundred-fold excess of naloxone at leu-enkephalin concentrations less than 10 ( -9 ) m . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
15,
25
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
89,
103
]
} |
stimulatory effect of phenobarbital on the metabolism of the oral contraceptive 17 alpha-ethynylestradiol-3-methyl ether ( mestranol ) by rat liver microsomes . | NA | {
"id": "C0015011",
"name": "ethynylestradiol",
"pos": [
89,
105
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
123,
132
]
} |
pretreatment of rats with phenobarbital for 4 days stimulates the activity of liver microsomal enzymes that metabolize 17 alpha-ethynylestradiol-3-methyl ether ( mestranol ) . | NA | {
"id": "C0015011",
"name": "ethynylestradiol",
"pos": [
128,
144
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
162,
171
]
} |
likewise , while a consistent relationship between the self-report of decreased appetite and final weight change was noted in the placebo group , no simple relationship between final weight change and self-reported changes in appetite were apparent in the drug-treated patients . | NA | {
"id": "C0005911",
"name": "weight change",
"pos": [
99,
112
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
183,
189
]
} |
owing to the biology of arteriosclerosis elderly previously affected patients have , as a rule , to undergo lower limb amputation for occlusive artery disease . | NA | {
"id": "C0003850",
"name": "arteriosclerosis",
"pos": [
24,
40
]
} | {
"id": "C0003838",
"name": "occlusive artery disease",
"pos": [
134,
158
]
} |
[ coagulation factors and blood platelets . ( presence and location of factor viii and of fibrinogen in normal human platelets and in patients with coagulation disorders , using an immunofluorescence technic ) ] . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
2,
21
]
} | {
"id": "C0015506",
"name": "factor viii",
"pos": [
71,
82
]
} |
medullar tissue was replaced by clumps of reticular cells , which later developed into differenciated cells ( fibroblasts , osteoblasts and osteoclasts ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
52,
57
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} |
ld50 of morphine sulfate + saline was 15 -- 16 times greater than for morphine + propranolol in both sexes although morphine was nearly twice as toxic to males as to females . | NA | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
8,
24
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
116,
124
]
} |
mortality after morphine and propranolol was antagonized by naloxone or naltrexone in rats and mice . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
60,
68
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
72,
82
]
} |
not only lithocholic acid , deoxycholic acid , chenodeoxycholic acid , hyodeoxycholic acid , ursodeoxycholic acid and cholic acid , but also alpha- and beta-muricholic acids were quantitatively and simultaneously detectable in conjugated and unconjugated fractions , respectively . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
28,
44
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic",
"pos": [
47,
63
]
} |
not only lithocholic acid , deoxycholic acid , chenodeoxycholic acid , hyodeoxycholic acid , ursodeoxycholic acid and cholic acid , but also alpha- and beta-muricholic acids were quantitatively and simultaneously detectable in conjugated and unconjugated fractions , respectively . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
28,
44
]
} | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
93,
113
]
} |
at 25 degrees c and ph 7.4 , an association constant ( ka ) of about 1.5 x 10 ( 6 ) m-1 and 2 sites/mole are measured with the des-afp system , whereas for the des-albumin interaction , we find a ka of approximately 2 x 10 ( 5 ) m-1 and about 11 sites/mole of protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
164,
171
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
260,
267
]
} |
as representative steroids , 19-nor-17 alpha-ethinyl testosterone ( 19-net ) and testosterone , and as representative acid , pivalic ( trimethylacetic ) acid were used . | NA | {
"id": "C0014594",
"name": "17 alpha",
"pos": [
36,
44
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
81,
93
]
} |
of the metabolites formed , 17 , 20 alpha-dihydroxypregn-4-en-3-one , 20 alpha-hydroxypregn-4-en-3-one , 20 beta-hydroxypregn-4-en-3-one , 5 alpha-pregnane-3 alpha , 17,20 alpha-triol , 5 beta-pregnane-3 alpha , 17,20 alpha-triol , 5 beta-pregnane-3 alpha,20 alpha-diol , 3 beta-hydroxy-5 alpha-pregnan-20-one , 3 alpha-hydroxy-5 beta-pregnan-20-one , 20 beta-hydroxy-5 beta-pregnan-3-one , 5 alpha-pregnane-3,20-dione and 5 beta-pregnane-3,20-dione were identified . | NA | {
"id": "C0033008",
"name": "3 alpha-hydroxy-5 beta-pregnan-20-one",
"pos": [
312,
349
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
430,
438
]
} |
all estrogen receptor poor tumors and 4 out of 8 estrogen receptor rich tumors converted pregnenolone to 17-hydroxypregnenolone . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
89,
101
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
105,
127
]
} |
the conversion of pregnenolone to 17-hydroxypregnenolone was significantly less in receptor rich tumors and was totally absent in 4 receptor rich tumors with estrogen receptors of over 45 fmol/mg protein . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
18,
30
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
34,
56
]
} |
effects of isomers of chondroitin sulfate on atherosclerosis were clinically compared , based on sulfate linkage and the amount of sulfate , by using chondroitin 4-sulfate , chondroitin 6-sulfate and chondroitin polysulfate . | NA | {
"id": "C0008466",
"name": "chondroitin sulfate",
"pos": [
22,
41
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
200,
211
]
} |
serum cholesterol value in the group treated by the isomers of chondroitin sulfate , chondroitin polysulfate group in particular , fell lower than the pre-treatment value . | NA | {
"id": "C0008466",
"name": "chondroitin sulfate",
"pos": [
63,
82
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
85,
96
]
} |
thus , these data indicated that the isomers of chondroitin sulfate are clinically effective on the treatment of atherosclerosis in the order of chondroitin polysulfate , chondroitin 4-sulfate and/or chondroitin 6-sulfate . | NA | {
"id": "C0008466",
"name": "chondroitin",
"pos": [
48,
59
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
200,
211
]
} |
the possible implication of the nuclear non-histone proteins in the process of ageing is discussed . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
32,
39
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
44,
51
]
} |
the classification after kiel distinguishes non-hodgkin-lymphomas of a malignity of low degree ( cll , centrocytoma , centroblastic-centrocytic lymphoma , immunocytomas ) and of high degree ( t-lymphoblastoma , centroblastoma , immunoblastoma ) . | NA | {
"id": "C0024305",
"name": "non-hodgkin-lymphomas",
"pos": [
44,
65
]
} | {
"id": "C0079746",
"name": "immunoblastoma",
"pos": [
228,
242
]
} |
90 % of the punctured blood donors had an overweight up to a maximum of 35 kg in comparison to the ideal weight . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
42,
52
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
105,
111
]
} |
the inability to work is essentially determined by 7 diagnoses -- gastritis and duodenitis , cholelithiasis , gastroenteritis and colitis , cholecystitis and cholangitis , ulcus ventriculi and duodeni , acute appendicitis . | NA | {
"id": "C0017152",
"name": "gastritis",
"pos": [
66,
75
]
} | {
"id": "C0017160",
"name": "gastroenteritis",
"pos": [
110,
125
]
} |
jores and others , he demonstrates the possibility of a new understanding of the meaning of some voice and speech disorders , particularly hysterical aphonia , spastic dysphonia , stuttering and so-called functional development symptoms ( which are found in the results of organic examinations in connection with speech disorders ) . | NA | {
"id": "C0038506",
"name": "stuttering",
"pos": [
180,
190
]
} | {
"id": "C0037822",
"name": "speech",
"pos": [
313,
319
]
} |
preparative separation of the isoenzymes were achieved by ion exchange chromatography on deae-sephacel but gel chromatography on sephadex g-100 gave the same elution volume for all enzyme phenotypes . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
30,
40
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
181,
187
]
} |
insulin response to an oral glucose load in relation to lp ( a ) /pre-beta 1-lipoprotein levels in non-diabetic patients with peripheral vascular disease and in controls . | NA | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
56,
62
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
77,
88
]
} |
29.6 % of the 227 had severe head injury ( concussion with or without a fractured skull ) . | NA | {
"id": "C0018674",
"name": "head injury",
"pos": [
29,
40
]
} | {
"id": "C0037304",
"name": "fractured skull",
"pos": [
72,
87
]
} |
some agents ( e.g . zk 62 711 , ici 63,197 , ro 20 -- 1724 , dipyridamol ) were considerably more potent as inhibitors of cyclic amp than of cyclic gmp hydrolysis , while other agents ( m & b 22.948 and dilazep ) selectively inhibited cyclic gmp breakdown , and some ( theophylline , papaverine , ibmx and sq 20,006 ) showed little selectivity . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
269,
281
]
} | {
"id": "C0000096",
"name": "ibmx",
"pos": [
297,
301
]
} |
the influence of selinium on methyl mercury toxicity in rat hepatoma cells , human embryonic fibroblasts and human lymphocytes in culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
93,
104
]
} |
inhibition of 5-ht uptake was found to increase progressively in the sequence methanol - ethanol - propanol - butanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
78,
86
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
89,
96
]
} |
adrenaline , apomorphine , carbachol and dihydralazine were as isoprenaline and noradrenaline without effect on renin release in sialoadenectomized and nephrectomized mice . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
80,
93
]
} |
although some authors report a high and stable relation between saliva and serum lithium concentration , we consider the saliva lithium level unreliable as a prediction of the serum lithium level in patients treated with lithium carbonate . | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
81,
88
]
} | {
"id": "C0085217",
"name": "lithium",
"pos": [
221,
228
]
} |
the rickettsia grows well in tissue culture systems including chick embryo fibroblast , vero , and vole tissue cells , when inoculated via yolk sac into 5-day-old hens ' eggs , it kills 100 % of the embryos after 5 to 7 days . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
75,
85
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} |
antisera demonstrated by precipitation and passive haemagglutination to posses antibodies specific for prostatic tissue-specific acid phosphatase have been employed to localize this isoenzyme in the prostate by indirect immunofluorescence . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
79,
89
]
} |
the phenotyic frequencies of the most representative hla of b locus in the group of patients shows an increase in the frequency of hla-b8 . | NA | {
"id": "C0019737",
"name": "hla",
"pos": [
53,
56
]
} | {
"id": "C0019746",
"name": "hla-b8",
"pos": [
131,
137
]
} |
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