text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component . | NA | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
34,
45
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
217,
227
]
} |
a light- and electron-microscopic review of 40 cases diagnosed at children 's hospital of pittsburgh as ganglioneuroblastoma , neuroblastoma , or small round cell tumor-probably neuroblastoma disclosed four cases that contained abundant glycogen . | NA | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
104,
124
]
} | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
178,
191
]
} |
207 patients of a geriatric department were immunized against influenza with either tween-ether-split-vaccine or subunit-vaccine in a double blind study . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
102,
109
]
} | {
"id": "C0887892",
"name": "subunit-vaccine",
"pos": [
113,
128
]
} |
the concentrations of adrenaline and noradrenaline , and dopamine-beta-hydroxylase in the plasma , and certain haemodynamic parameters , were determined in 14 children undergoing surgical correction of congenital cardiac defects under hypothermia at 30 degrees c and methoxyflurane anaesthesia . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
22,
32
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
37,
50
]
} |
in 25 cases of germinal testicular tumours of the adult , a technique of indirect immunoperoxydase was applied to histological sections with the aim of demonstrating a substance reacting with an anti-beta hcg antibody ( sub-unit of chorionic gonadotrophin hormone ) . | NA | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
200,
208
]
} | {
"id": "C0018062",
"name": "chorionic gonadotrophin",
"pos": [
232,
255
]
} |
[ growth hormone deficiency during the course of histiocytoses . a report on a case of hand-schuller-christian disease ( author 's transl ) ] . | NA | {
"id": "C0019618",
"name": "histiocytoses",
"pos": [
49,
62
]
} | {
"id": "C0019621",
"name": "hand-schuller-christian disease",
"pos": [
87,
118
]
} |
but it is the first time , to our knowledge , that a cross-sensitivity between ribostamycin and neomycin is observed . | NA | {
"id": "C0035554",
"name": "ribostamycin",
"pos": [
79,
91
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
96,
104
]
} |
only three rings are found in ribostamycin : ribostamycin is constitued of neomycin lacking neosamin of neobiosamin . | NA | {
"id": "C0035554",
"name": "ribostamycin",
"pos": [
30,
42
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
75,
83
]
} |
thus the structure of the 3 rings of ribostamycin is identical with the structure of 3 out of 4 rings of neomycin . | NA | {
"id": "C0035554",
"name": "ribostamycin",
"pos": [
37,
49
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
105,
113
]
} |
the liver homogenates of these rats had an increase in protein and rna on a dna basis and an increase in lipid and a decrease in dna on the liver weight basis . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
76,
79
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
154,
155
]
} |
granulocyte-specific antinuclear antibodies ( gs-ana ) were detected in the sera of 5 of 88 patients with ankylosing spondylitis ( as ) and in 7 of 52 cases of psoriatic arthritis ( psa ) , but were not found in 91 patients with malignant or non-malignant chest disease nor in 25 cases of psoriasis . | NA | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
160,
179
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
289,
298
]
} |
even though promastigotes of l. h. hertigi do not produce an ef that precipitates with homologous antibody , n-a bodies containing agglutinated cells separated by a thin structured layer of precipitate were formed during growth in homologous antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
98,
106
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
242,
251
]
} |
the ffa fraction of cardiac lymph contained relatively more stearic acid and less oleic acid whereas , in plasma , the ffa fraction contains less myristic acid . | NA | {
"id": "C0015684",
"name": "ffa",
"pos": [
4,
7
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
119,
122
]
} |
the data are consistent with the hypothesis that endothelial permeability is a limiting factor for the transvascular exchanges of large molecules such as tg and that the ffa distribution in intersititial spaces may have been modified by the contribution of fatty acids from endogenous cardiac reserves or from the hydrolysis of plasma tg . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
170,
173
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
257,
268
]
} |
no significant effect of vitamin supplementation on organ cholesterol concentration was noted at 24 weeks although serum cholesterol concentration was significantly lower for the vitamin- fed groups at all levels of dietary cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
58,
69
]
} | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
216,
235
]
} |
comparison of the effects of ethane-1-hydroxy-1,1-diphosphonate and dichloromethylene diphosphonate upon periodontal bone resorption in rice rats ( oryzomys palustris ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
50,
63
]
} | {
"id": "C0012081",
"name": "dichloromethylene diphosphonate",
"pos": [
68,
99
]
} |
the expression of this enzyme was concordant with that of mitochondrial aconitase ( acon-m ) , an isozyme assigned to chromosome 22 , in all 50 clones and with chromosome 22 segregation in all but one of the 29 karyotyped hybrids . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
23,
29
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
98,
105
]
} |
the new albumin esterase component which separated from the es-2 esterase was identified as the product of the es-1b gene . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
8,
15
]
} | {
"id": "C0033684",
"name": "product",
"pos": [
96,
103
]
} |
the fluoride numbers ( fn ) of 144 individuals referred to our laboratory for dibucaine number ( dn ) determinations because of prolonged apnea following succinylcholine in the probands or relatives were determined by our new method using 2.5 x 10 ( 4 ) m concentration of sodium fluoride at 37 c . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
4,
12
]
} | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
273,
288
]
} |
the concentration of beta-alanine , formed from uracil by the same enzyme system catalyzing formation of d-baib from thymine , was not different in the liver and kidney of both sexes after an intraperitoneal injection of uracil . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
117,
124
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
221,
227
]
} |
when oviducts from vitamin a-depleted and vitamin a-repleted immature chicks given oestrogen injections for 6 consecutive days were incubated with [ 3h ] retinyl acetate , uptake of the radioactivity in the nuclei of the vitamin a-depleted tissue was severalfold higher than that in the nuclei from the vitamin a-repleted tissue . | NA | {
"id": "C0073109",
"name": "retinyl acetate",
"pos": [
154,
169
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
303,
312
]
} |
the concentration-dependence for activation and stabilization by the naturally occurring guanine nucleotides was examined in the absence of a regenerating system and revealed gmp to have no stabilizing effect and to be less potent than either gdp or gtp in activating adenylate cyclase . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
89,
108
]
} | {
"id": "C0018346",
"name": "gmp",
"pos": [
175,
178
]
} |
the concentration-dependence for activation and stabilization by the naturally occurring guanine nucleotides was examined in the absence of a regenerating system and revealed gmp to have no stabilizing effect and to be less potent than either gdp or gtp in activating adenylate cyclase . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
89,
108
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
250,
253
]
} |
the significance of the change in intensity is considered with reference to the interpretation of the equatorial patterns obtained from muscles in different physiological states . | NA | {
"id": "C0025320",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C2916830",
"name": "physiological states",
"pos": [
157,
177
]
} |
35so42- - and [ 3h ] -leucine-labelled proteoglycans were isolated from the medium of a fibroblast culture , from an edta extract of the monolayer , and from consecutive dithiothreitol and guanidine hydrochloride extracts of the cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
88,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
229,
234
]
} |
the results indicate that the area of the heparan sulphate chain where disaccharides containing n-acetylglucosamine and n-sulphated glucosamine residues alternate is higher in sulphate content than expected and that the sulphate groups are mainly located on the hexosamine units . | NA | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
98,
115
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
132,
143
]
} |
of the glycoproteins tested only two , human lactoferrin ( terminal fucosyl alpha 1 leads to 3 n-acetylglucosamine ) and bovine asialo-fetuin ( terminal galactosyl beta 1 leads to 4 n-acetylglucosamine ) were weakly competitive . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
7,
20
]
} | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
45,
56
]
} |
the alpha-sympatholytical properties of nicergoline were more precisely proved by reducing the reactive increase in blood pressure after epinephrine and norepinephrine ( 3 micrograms/kg ) by administration of nicergoline in 3 doses ( 25 , 50 and 100 micrograms/kg ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
137,
148
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
153,
167
]
} |
sulphate , thiosulphate and sulphite were transported across the envelope leading to an accumulation in the chloroplasts . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
0,
8
]
} | {
"id": "C0039950",
"name": "thiosulphate",
"pos": [
11,
23
]
} |
the urinary excretion of adrenaline , noradrenaline and cortisol , heart rate ( in the understimulation and baseline conditions ) and self-reports were used as indices of arousal . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
apomorphine , a direct-acting dopamine agonist , stimulates release of growth hormone ( hgh ) and suppresses release of prolactin ( prl ) from the anterior pituitary . | NA | {
"id": "C0037663",
"name": "growth",
"pos": [
71,
77
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
88,
91
]
} |
apomorphine , a direct-acting dopamine agonist , stimulates release of growth hormone ( hgh ) and suppresses release of prolactin ( prl ) from the anterior pituitary . | NA | {
"id": "C0037663",
"name": "growth",
"pos": [
71,
77
]
} | {
"id": "C0032016",
"name": "anterior",
"pos": [
147,
155
]
} |
purification of a basic somatomedin , from human plasma cohn fraction iv-1 , with physicochemical and radioimmunoassay similarity to somatomedin-c and insulin-like growth factor . | NA | {
"id": "C0021666",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0037657",
"name": "insulin-like growth factor",
"pos": [
151,
177
]
} |
purification of a basic somatomedin , from human plasma cohn fraction iv-1 , with physicochemical and radioimmunoassay similarity to somatomedin-c and insulin-like growth factor . | NA | {
"id": "C0021665",
"name": "somatomedin-c",
"pos": [
133,
146
]
} | {
"id": "C0037657",
"name": "insulin-like growth factor",
"pos": [
151,
177
]
} |
the purified sm has an approximate molecular weight of 7500 , pi 8.6 , 4000 sm bioactivity units per milligram ( as measured by a hypophysectomized rat bioassay ) and a parallel approximately equipotent radioimmunoassay dose -- response curve to sm-c and insulin-like growth factor-1 ( igf-i ) . | NA | {
"id": "C0037657",
"name": "sm",
"pos": [
13,
15
]
} | {
"id": "C0021666",
"name": "a",
"pos": [
276,
277
]
} |
the purified sm has an approximate molecular weight of 7500 , pi 8.6 , 4000 sm bioactivity units per milligram ( as measured by a hypophysectomized rat bioassay ) and a parallel approximately equipotent radioimmunoassay dose -- response curve to sm-c and insulin-like growth factor-1 ( igf-i ) . | NA | {
"id": "C0037657",
"name": "sm",
"pos": [
13,
15
]
} | {
"id": "C0021665",
"name": "insulin-like growth factor-1",
"pos": [
255,
283
]
} |
the preliminary determination of the amino acid sequence of the n terminus suggested that this sm preparation was over 75 % pure and the first five n-terminal amino acids were identical with those of igf-i . | NA | {
"id": "C0037657",
"name": "sm preparation",
"pos": [
95,
109
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
200,
205
]
} |
irradiation , using ultraviolet light , of the solution containing compound ii and persulfate in the presence of bicarbonate , chloride , or bromide , leads ot the fast accumulation of compound i due to the oxidative action of so4 , co3 , cl2 , and br2 anion radicals , which are products of the photolysis . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
127,
135
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
253,
258
]
} |
irradiation , using ultraviolet light , of the solution containing compound ii and persulfate in the presence of bicarbonate , chloride , or bromide , leads ot the fast accumulation of compound i due to the oxidative action of so4 , co3 , cl2 , and br2 anion radicals , which are products of the photolysis . | NA | {
"id": "C0006222",
"name": "bromide",
"pos": [
141,
148
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
253,
258
]
} |
irradiation , using ultraviolet light , of the solution containing compound ii and persulfate in the presence of bicarbonate , chloride , or bromide , leads ot the fast accumulation of compound i due to the oxidative action of so4 , co3 , cl2 , and br2 anion radicals , which are products of the photolysis . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
0,
1
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
253,
258
]
} |
the principal fatty acids of a. chroococcum were hexadecanoic ( c16:0 ) , hexadecenoic ( c16:1 ) , and octadecenoic acid ( c18:1 ) at all o2 tensions , but c18:1 increased at the expense of c16:1 at higher o2 tensions , particularly in free fatty acid and phospholipid fractions . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
14,
25
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
236,
251
]
} |
cultivation of s. sclerotivorum parasitically on living sclerotia proceeded optimally in moist , fine quartz sand amended with 1 to 2 % ( w/w ) sclerotia and 0.07 % ( w/w ) caco3 , at 25 degrees c . | NA | {
"id": "C0034387",
"name": "quartz",
"pos": [
102,
108
]
} | {
"id": "C0037098",
"name": "sand",
"pos": [
109,
113
]
} |
spleen cells from germfree rats , conventionally reared rats , and gnotobiotic rats associated with two pseudomonas species gave no positive blastogenic response when incubated with each of four lipopolysaccharide ( lps ) preparations from escherichia coli , with glycolipid extracted from salmonella minnesota r595 or with s. minnesota r595 lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
195,
213
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
342,
349
]
} |
effect of degree of polymerization of silicic acid on the gastrointestinal absorption of silicate in rats . | NA | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
38,
50
]
} | {
"id": "C0086983",
"name": "silicate",
"pos": [
89,
97
]
} |
acute and chronic effects of nifedipine on plasma renin activity and plasma adrenaline and noradrenaline in controls and hypertensive patients . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
76,
86
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
91,
104
]
} |
plasma renin concentration [ renin ] , plasma angiotensin ii concentration ( [ ang ii ] ) , plasma volume and exchangeable sodium ( nae ) were determined , and a saralasin infusion ( 5.4 nmol min-1 kg-1 ) was carried out while the patients were on thiazide alone and , in 14 cases , 3 months after addition of a beta-adrenoreceptor blocker ( propranolol , six , metoprolol , six , and atenolol , two patients ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
46,
60
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
162,
171
]
} |
plasma noradrenaline and adrenaline significantly and markedly increased in the same subjects when sympathetic activity was increased by activation of both arterial and low pressure baroreceptor reflexes with tilting . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} |
plasma normetanephrine and noradrenaline concentrations varied in direct proportion to activation or suppression of sympathetic nerve function . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
7,
22
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} |
plasma normetanephrine and noradrenaline concentrations and urinary normetanephrine excretion rates were increased in some young patients with primary hypertension , suggesting that sympathetic nerve hyperactivity is a pathogenic factor in these patients . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
68,
83
]
} |
eight weeks after sympathectomy plasma noradrenaline and dopamine were not elevated , but plasma adrenaline has increased twofold . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
97,
107
]
} |
noradrenaline- and adrenaline , but not dopamine-containing neurones may participate in regulation of sympathetic efferent activity . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
19,
29
]
} |
in both groups a significant increase of noradrenaline and adrenaline in blood and noradrenaline in urine was observed . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
41,
54
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
86,
96
]
} |
adrenocorticotropin ( acth ) -induced steroidogenesis , obtained by continuous administration of acth for 3 days , produces in man ( a ) sustained elevations of plasma deoxycorticosterone and cortisol concentrations , ( b ) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values , and ( c ) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68 % of peak values 30 h thereafter . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
271,
295
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
426,
440
]
} |
the effects of 300 microgram of oral clonidine on blood pressure , heart rate , plasma noradrenaline and adrenaline concentrations were studied in seven tetraplegic subjects with physiologically complete cervical spinal cord transections . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
105,
115
]
} |
resting plasma noradrenaline and adrenaline concentrations , when measured 2 h after clonidine , were not significantly lower . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
33,
43
]
} |
urinary bladder stimulation resulted in a marked rise in blood pressure accompanied by an elevation in plasma noradrenaline but not adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
132,
142
]
} |
an intravenous glipizide ( 2 mg ) test was carried out in 7 patients before and after a period of associated insulin-glipizide treatment ( mean daily dose of 80.7 i.v . lente insulin and 14.3 mg glipizide for 9.1 months ) to assess the capacity of the sulphonylurea to reduce acutely the plasma glucose and lactate levels . | NA | {
"id": "C0017642",
"name": "glipizide",
"pos": [
15,
24
]
} | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
252,
265
]
} |
epidermal growth factor ( egf ) receptors were demonstrated in cultured bovine odontogenic epithelial and ectomesenchymal cells and in rat embryonic and foetal lung fibroblasts by immunofluorescent reactivity with egf and anti-egf traced with a fluorescein-isothiocyanate-labelled goat anti-rabbit globulin . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
122,
127
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
165,
176
]
} |
lingual serous glands ( von ebner ) contain a potent lipase that hydrolyses triglycerides to a mixture of partial glycerides ( di- and monoglycerides ) , glycerol and free fatty acids . | NA | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
76,
89
]
} | {
"id": "C0017860",
"name": "glycerides",
"pos": [
139,
149
]
} |
lingual serous glands ( von ebner ) contain a potent lipase that hydrolyses triglycerides to a mixture of partial glycerides ( di- and monoglycerides ) , glycerol and free fatty acids . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
79,
89
]
} | {
"id": "C0026481",
"name": "monoglycerides",
"pos": [
135,
149
]
} |
a laryngologist with seborrhoic dermatitis , strongly positive to formaldehyde , had exacerbations when using -- during surgery -- a microscope disinfected with formalin solution . | NA | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
66,
78
]
} | {
"id": "C0949307",
"name": "formalin",
"pos": [
161,
169
]
} |
metabolism , excretion , and tissue distribution of [ 14c ] photodieldrin in nonhuman primates following oral administration and intravenous injection . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
0,
10
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
13,
22
]
} |
the effects of intracerebroventricular administrations of three natural angiotensins , angiotensin i ( ang i 3.8 x 10-11-9.4 x10-10 mol/kg body weight ) , ii ( 9.6 x 10-12-2.4 x 10-10 mol/kg body weight ) and iii ( 2.7 x 10-10 2.5 x 10-9 mol/kg body weight ) on systemic blood pressure were investigated in conscious rats . | NA | {
"id": "C0003018",
"name": "angiotensins",
"pos": [
72,
84
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
87,
100
]
} |
the intraventricular administration of a converting enzyme inhibitor ( sq 14225 , 6.9 x10-8 mol/kg ) abolished the central effect of ang i , while an angiotensin ii analogue ( [ sar1-ala8 ] ang ii , 1.1 x 10-8 mol/kg ) administered intraventricularly inhibited the central pressor effects of these three angiotensins . | NA | {
"id": "C0003009",
"name": "ang ii",
"pos": [
190,
196
]
} | {
"id": "C0003018",
"name": "angiotensins",
"pos": [
304,
316
]
} |
those that cause the malabsorption syndrome , i.e. , steatorrhea and weight loss , can be conveniently categorized according to the major deficiency leading to the absorptive defect as follows : insufficient pancreatic enzyme activity , insufficient bile acid , disease of the small intestinal wall , multiple defects , mechanism unknown , and drug-induced malabsorption . | NA | {
"id": "C0024523",
"name": "malabsorption syndrome",
"pos": [
21,
43
]
} | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
53,
64
]
} |
those that cause the malabsorption syndrome , i.e. , steatorrhea and weight loss , can be conveniently categorized according to the major deficiency leading to the absorptive defect as follows : insufficient pancreatic enzyme activity , insufficient bile acid , disease of the small intestinal wall , multiple defects , mechanism unknown , and drug-induced malabsorption . | NA | {
"id": "C0024523",
"name": "malabsorption syndrome",
"pos": [
21,
43
]
} | {
"id": "C0021831",
"name": "disease of the",
"pos": [
262,
276
]
} |
liver is the major site of metabolism of xenobiotics , but the contribution of intestinal metabolism of xenobiotic can influence the overall bioavailability of chemicals . | NA | {
"id": "C1373176",
"name": "site of metabolism",
"pos": [
19,
37
]
} | {
"id": "C1373177",
"name": "intestinal metabolism",
"pos": [
79,
100
]
} |
the possibility of correlating signs of necrosis with particular patterns of hypokinesia , akinesia , dyskinesia which differ from corresponding `` '' static '' '' forms of asynergy in active pressure development and deformation ( even in a brief systolic interval ) seems to confirm the physiopathologic interpretation of the regional phenomenon based on the ratio between viable not viable myocardium -- as primary cause . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
77,
88
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
102,
112
]
} |
chloramphenicol is the most common offender , but in many countries it now has been replaced by the anti-inflammatory agents phenylbutazone and oxyphenbutazone . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
125,
139
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
144,
159
]
} |
[ effects of external ca2+ , dobutamine and other catecholamines on the ca2+-dependent electrical response ( author 's transl ) ] . | NA | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
29,
39
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
50,
64
]
} |
it has been well documented that fever could be mediated with endogenous pyrogen released from reticuloendothelial system ( res ) by administration of bacterial endotoxin ( lps ) intravenously to rabbits . | NA | {
"id": "C0014264",
"name": "bacterial",
"pos": [
151,
160
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
173,
176
]
} |
in this paper , we focussed our attention on the effect of reserpine on the production of endogenous pyrogen with relation to the antipyretic effect in endotoxin fever and obtained the following results : endogenous pyrogen could be detected by intravenous administration of lps ( 0.5 micrograms/kg ) during the fever . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
152,
161
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
275,
278
]
} |
it thus appears that gaba is involved in the effect of diazepam on the phasic component , and noradrenaline is involved in the same effect of baclofen in anemic decerebrate rats . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
21,
25
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
142,
150
]
} |
a first population of fcs-primed cells had `` '' promoter '' '' activity , in the sense that it could trigger a second population of `` '' precursor '' '' cells to differentiate into polyclonally cytolytic t cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
33,
38
]
} | {
"id": "C0018956",
"name": "`` '' precur",
"pos": [
133,
145
]
} |
leucocytes were treated by plastic adherence and iron filings , passed over a nylon column and subsequently over an ig-anti-ig column , and then rosetted with srbc . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
27,
34
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
78,
83
]
} |
to determine if alterations of the renin-angiotensin axis observed in patients with established hypertension also occur in young adults with relatively high blood pressure , plasma renin activity ( pra ) , plasma renin concentration ( prc ) , plasma renin substrate ( prs ) and plasma renin reactivity ( prr ) were compared in these two groups of subjects . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
41,
52
]
} | {
"id": "C0003017",
"name": "renin substrate",
"pos": [
250,
265
]
} |
for this purpose , rats with chronic , two-kidney goldblatt hypertension ( one renal artery clamped and contralateral untouched ) were tested for their bp response to the aiia ( 1-sar-8-ala-angiotensin ii ) and to the converting enzyme inhibitor ( cei ) sq20,881 , which is devoid of agonistic effect . | NA | {
"id": "C0003009",
"name": "aiia",
"pos": [
171,
175
]
} | {
"id": "C0036193",
"name": "1-sar-8-ala-angiotensin ii",
"pos": [
178,
204
]
} |
when sar1-ala8 angiotensin ii was used to antagonize the action of angiotensin , the fall in bp was also linearly related to log . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
15,
29
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
67,
78
]
} |
deep freezing of buffalo bull semen using egg yolk-citrate and citric acid when diluents and its performance in the field . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
51,
58
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
63,
74
]
} |
finally , the trial showed that a reduction of the number of components of a compound analgesic to some degree reduced the pain relieving effect on this particular postoperative pain . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
123,
127
]
} | {
"id": "C0030201",
"name": "postoperative pain",
"pos": [
164,
182
]
} |
the if induced by ks-2 shared certain physico-chemical properties with the standard preparation of immune if and was not neutralized by an antiserum against type i if . | NA | {
"id": "C0021747",
"name": "if",
"pos": [
4,
6
]
} | {
"id": "C0021745",
"name": "immune if",
"pos": [
99,
108
]
} |
the if induced by ks-2 shared certain physico-chemical properties with the standard preparation of immune if and was not neutralized by an antiserum against type i if . | NA | {
"id": "C0021747",
"name": "if",
"pos": [
4,
6
]
} | {
"id": "C0021743",
"name": "type i if",
"pos": [
157,
166
]
} |
evaluation of the antibacterial activity against a series of mutants producing different levels of beta-lactamases and test of the susceptibilities to some beta-lactamases demonstrated that tei-1194 and tei-2012 had low susceptibility to various cephalosporinases . | NA | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
99,
114
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
246,
263
]
} |
cefadroxil ( duricef , mead johnson and company ) , resembles cephalexin and cephradine in spectrum of antibacterial activity but differs in human pharmacokinetic properties . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
0,
10
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
62,
72
]
} |
cefadroxil ( duricef , mead johnson and company ) , resembles cephalexin and cephradine in spectrum of antibacterial activity but differs in human pharmacokinetic properties . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
62,
72
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
77,
87
]
} |
in this kinetic model , cefadroxil was more active than cephalexin or cephradine against staphylococcus aureus , streptococcus pneumoniae , klebsiella pneumoniae , proteus mirabilis , haemophilus influenzae and one of two strains of escherichia coli . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
24,
34
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
56,
66
]
} |
in this kinetic model , cefadroxil was more active than cephalexin or cephradine against staphylococcus aureus , streptococcus pneumoniae , klebsiella pneumoniae , proteus mirabilis , haemophilus influenzae and one of two strains of escherichia coli . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
56,
66
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
70,
80
]
} |
decreased motility is observed with normal mouse balb/c 3t3 cells , mouse l929 cells , rat kidney fibroblasts and chick embryo fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
127,
138
]
} |
complementary studies of potassium efflux showed a 1.3- to 1.5-fold higher rate ( based on the percentage of pool exiting the cell ) in growing normal versus density-inhibited or transformed fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
126,
130
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
191,
202
]
} |
because of the larger potassium pool in transformed cells , efflux based on absolute number of potassium ions is similar in normal and transformed chicken embryo fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
52,
57
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
162,
173
]
} |
the polyamines , obtained after clean-up of deproteinized serum by cellex p column chromatography , are converted to their fluorescamine derivatives in the presence of nickel ion which inhibits the reaction of interfering amines with fluorescamine , and the derivatives are separated simultaneously by reversed-phase chromatography ( lichrosorb rp-18 ) with a linear gradient elution . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
4,
14
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
222,
228
]
} |
the half-lives of aza breakdown to 6mp at 37 degrees were 28 and 46 min in blood drawn from two rhesus monkeys . | NA | {
"id": "C0004482",
"name": "aza",
"pos": [
18,
21
]
} | {
"id": "C0000618",
"name": "degrees",
"pos": [
45,
52
]
} |
6mp levels were also measured in three renal transplant patients on daily 50- and 100-mg aza doses . | NA | {
"id": "C0000618",
"name": "levels",
"pos": [
4,
10
]
} | {
"id": "C0004482",
"name": "aza",
"pos": [
89,
92
]
} |
estimation of chlorambucil , phenyl acetic mustard and prednimustine in human plasma by high-performance liquid chromatography . | NA | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
14,
26
]
} | {
"id": "C0032949",
"name": "prednimustine",
"pos": [
55,
68
]
} |
a sensitive and specific method for the determination of diamines and polyamines by ion-pair high-performance liquid chromatography is described . | NA | {
"id": "C0011957",
"name": "diamines",
"pos": [
57,
65
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
70,
80
]
} |
determination of dopa , dopamine , dopac , epinephrine , norepinephrine , alpha-monofluoromethyldopa and alpha-difluoromethyldopa in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detection . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} |
b using octanesulfonic acid for ion pairing and by optimising ionic strength , ph and methanol concentration of the mobile phase , separation was achieved of 3,4-dihydroxyphenylalanine ( dopa ) , 3,4-dihydroxyphenylacetic acid ( dopac ) , norepinephrine ( ne ) , epinephrine ( epi ) , and dopamine ( da ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
239,
253
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
263,
274
]
} |
a high-performance liquid chromatographic method is described for the simultaneous determination of methylprednisolone ( mp ) and methylprednisolone hemisuccinate ( mphs ) , or hydrocortisone ( hc ) and hydrocortisone hemisuccinate ( hchs ) in human serum . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
100,
118
]
} | {
"id": "C0025819",
"name": "methylprednisolone",
"pos": [
130,
148
]
} |
the sensitivity is 0.03 microgram/ml for hc , 0.07 microgram/ml for mp , 0.04 microgram/ml for mphs , and 0.10 microgram/ml for hchs , with a detection limit of 0.02 microgram/ml for all four steroids . | NA | {
"id": "C0025815",
"name": "mp",
"pos": [
68,
70
]
} | {
"id": "C0025819",
"name": "mphs",
"pos": [
95,
99
]
} |
calibration curves are linear up to 3 micrograms/ml for mp or mphs ( as equivalent mp ) and up to 4 micrograms/ml for hc and 7 micrograms/ml ( as equivalent hc ) for hchs . | NA | {
"id": "C0025819",
"name": "mphs",
"pos": [
62,
66
]
} | {
"id": "C0025815",
"name": "mp",
"pos": [
83,
85
]
} |
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