text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
plasma concentration -- time curves are reported for mp and mphs or hc and hchs of two human subjects following intramuscular administration of 125 mg of methylprednisolone sodium succinate for injection , u.s.p. , or 250 mg of hydrocortisone sodium succinate for injection , u.s.p . | NA | {
"id": "C0025815",
"name": "mp",
"pos": [
53,
55
]
} | {
"id": "C0025819",
"name": "mphs",
"pos": [
60,
64
]
} |
plasma concentration -- time curves are reported for mp and mphs or hc and hchs of two human subjects following intramuscular administration of 125 mg of methylprednisolone sodium succinate for injection , u.s.p. , or 250 mg of hydrocortisone sodium succinate for injection , u.s.p . | NA | {
"id": "C0025815",
"name": "mp",
"pos": [
53,
55
]
} | {
"id": "C0700546",
"name": "methylprednisolone sodium succinate",
"pos": [
154,
189
]
} |
plasma concentration -- time curves are reported for mp and mphs or hc and hchs of two human subjects following intramuscular administration of 125 mg of methylprednisolone sodium succinate for injection , u.s.p. , or 250 mg of hydrocortisone sodium succinate for injection , u.s.p . | NA | {
"id": "C0025819",
"name": "mphs",
"pos": [
60,
64
]
} | {
"id": "C0700546",
"name": "methylprednisolone sodium succinate",
"pos": [
154,
189
]
} |
the assay involves the enzymatic o-methylation of salsolinol by catechol-o-methyltransferase in presence of [ 3h ] s-adenosylmethionine , and subsequent separation by thin-layer chromatography of the resultant [ 3h ] o-methyl-salsolinol from the o-methylated derivatives of dopamine , epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
285,
296
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
301,
315
]
} |
high-performance liquid chromatography ( hplc ) was used to separate tryptic peptides of the normal alpha , beta , gamma , and delta chains of human hemoglobins a , f , and a2 and of the abnormal chains of 25 hemoglobin variants . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
149,
160
]
} | {
"id": "C0019047",
"name": "abnormal",
"pos": [
187,
195
]
} |
short columns of a 4 % crosslinked cation-exchange resin gave good chromatography of xanthines , including caffeine , theophylline and hypoxanthine , and related polar aromatic compounds . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
85,
94
]
} | {
"id": "C0006644",
"name": "caffeine",
"pos": [
107,
115
]
} |
short columns of a 4 % crosslinked cation-exchange resin gave good chromatography of xanthines , including caffeine , theophylline and hypoxanthine , and related polar aromatic compounds . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
85,
94
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
118,
130
]
} |
mannan was not detected in sera from 11 patients with superficial candida infections , seven patients colonized with candida , three patients with chronic mucocutaneous candidiasis , eight patients with other systemic mycoses , or 22 normal donors . | NA | {
"id": "C0006840",
"name": "candida infections",
"pos": [
66,
84
]
} | {
"id": "C0006845",
"name": "chronic mucocutaneous",
"pos": [
147,
168
]
} |
this paper reported the species identification of bloodstains and muscles by means of an absorption test in which antisera were absorbed by bloodstains or muscles and then the absorbed antibody capacity was titrated by using latex particles coated with corresponding serum proteins . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
114,
122
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
185,
193
]
} |
a novel protein , designated protein iid* ( mol . wt 28 850 ) , was identified within the set of heat-modifiable surface proteins previously reported . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
8,
15
]
} | {
"id": "C0025252",
"name": "surface",
"pos": [
113,
120
]
} |
a study of the rate of hybridization of cap dna to cell dna at various driver to probe ratios showed that its rate of hybridization is similar to that of tumour cell dna reassociation . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
166,
169
]
} |
further , in reassociation studies accelerated by using the phenol emulsion reassociation technique ( pert ) , cap dna originally isolated as single-stranded dna was shown to reanneal ( 70 % ) , to protect 125i-cell dna to the same extent ( 67 % ) and to do so with kinetics of reassociation equivalent to that of mouse dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
142,
161
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
320,
323
]
} |
virus that had been irradiated with u.v . light , although still able to suppress synthesis of cellular protein and dna , did not induce phosphorylation of the 48k ribosomal protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
104,
111
]
} | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
164,
181
]
} |
3h-fucose and 14c-glucosamine labelled glycopeptides of the individual membrane proteins e1 , e2 and e3 of semliki forest virus could be sequentially digested with alpha-neuraminidase , beta-galactosidase , n-acetyl-beta-glucosaminidase , alpha- and beta-mannosidase , n-acetyl-beta-hexosaminidase and finally with alpha-fucosidase . | NA | {
"id": "C0001057",
"name": "n-acetyl-beta-glucosaminidase",
"pos": [
207,
236
]
} | {
"id": "C0005270",
"name": "beta-hexosaminidase",
"pos": [
278,
297
]
} |
this suggests that all three membrane glycoproteins of semliki forest virus contained glycans with a monosaccharide sequence characteristic for lactosamine type oligosaccharides . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
86,
93
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
161,
177
]
} |
other virus coded proteins and a host cell protein were present in the partially purified replication complex but were removed by digestion with ribonuclease t1 , leaving only the major virus coded protein . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
6,
11
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
198,
205
]
} |
chicken fibroblasts and mdck cells were infected with influenza virus labelled with either 3h-uridine or 14c-amino acids , and the location in infected cells and properties of input virus-labelled structures were studied . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
8,
19
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
127,
130
]
} |
in culture cells productively infected by adenovirus a high mol . wt . form of dna is synthesized which is known to represent , at least in part , virus dna integrated into cellular dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
42,
43
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
182,
185
]
} |
in addition to neutralizing antibody , lcm virus-infected mice produced sensitizing antibody ( detected by the enhancing effect of an anti-mouse ig antiserum on the ability of a serum to reduce virus infectivity ) and complement-fixing antibody . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
15,
36
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
236,
244
]
} |
in addition to neutralizing antibody , lcm virus-infected mice produced sensitizing antibody ( detected by the enhancing effect of an anti-mouse ig antiserum on the ability of a serum to reduce virus infectivity ) and complement-fixing antibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
28,
36
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
148,
157
]
} |
rabbit antisera to these hemagglutinating components possessed type-specific hemagglutination-inhibition and serum neutralization antibodies and were thoroughly evaluated for potency and specificty in immunodiffusion ( id ) , immunoelectrophoresis , and counterelectrophoresis ( ce ) tests . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
130,
140
]
} |
using human serum albumin ( hsa ) as a model , we have studied the efficiency of the reaction of hsa with the mixed acid anhydride of the quarternary triethyl ammonium salt of dtpa and butyl formate , as a function of the ratio of albumin to dtpa . | NA | {
"id": "C0304925",
"name": "hsa",
"pos": [
28,
31
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
231,
238
]
} |
the amino acid imbalance was created by adding 8 % of an indispensable amino acid mixture lacking threonine to a 6 % casein diet supplemented with 0.3 % methionine . | NA | {
"id": "C0002525",
"name": "indispensable amino acid",
"pos": [
57,
81
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
98,
107
]
} |
the amino acid imbalance was created by adding 8 % of an indispensable amino acid mixture lacking threonine to a 6 % casein diet supplemented with 0.3 % methionine . | NA | {
"id": "C0002525",
"name": "indispensable amino acid",
"pos": [
57,
81
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
153,
163
]
} |
a method using preparative and analytical high-performance liquid chromatography ( hplc ) is proposed for the assay of 25-hydroxyvitamin d3 ( 25-oh-d3 ) in human plasma . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
119,
139
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
142,
150
]
} |
immunoprecipitates of extracts of simian virus 40-infected permissive monkey kidney cells contained two proteins with molecular weights of 56,000 and 32,000 ( 52k and 32k ) in addition to the known viral early gene products . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
198,
203
]
} |
immunoprecipitates of cells infected with the 0.54-0.59 deletion mutants that lack the viral 17k gene product did not contain thhe 56k and 32k proteins . | NA | {
"id": "C0042736",
"name": "viral",
"pos": [
87,
92
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
143,
151
]
} |
the proteins can also be identified in uninfected cells by co-precipitation with unlabeled viral proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
91,
105
]
} |
thus , it appears that the 56k and 32k proteins are cellular products that associate with the viral proteins , the 17k in particular , and are indirectly immunoprecipitated by anti-tumor serum . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
39,
47
]
} | {
"id": "C0042736",
"name": "viral proteins",
"pos": [
94,
108
]
} |
because ( i ) the conserved 5 ' gag-related and internal rna segments and their gag-related , nonvirion protein products correlate with the conserved oncogenic spectra of the mc29 group of viruses and because ( ii ) the internal rna sequences and nonvirion proteins are not found in nondefective viruses , we propose that the conserved rna and protein elements are necessary for oncogenicity and probably are the onc gene products of the mc29 group of viruses . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
257,
265
]
} | {
"id": "C0042736",
"name": "gene products",
"pos": [
417,
430
]
} |
it also suggests that a discontinuity or nick is present in each strand of the circular dna molecule after the single-stranded region is made double stranded by the virion dna polymerase reaction . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
79,
91
]
} | {
"id": "C0012854",
"name": "double stranded",
"pos": [
142,
157
]
} |
the sum of the two fragments generated by each totaled 3,510 base pairs , 310 base pairs greater than the contour length of circular hepatitis b virus dna which represents a third estimate of the distance between the discontinuities in the two dna strands of circular dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
259,
271
]
} |
restriction endonuclease cleavage also indicated that the ends of heated linear dna which correspond to the discontinuities in the two strands of the circular dna are at unique sites in the dna with respect to the restriction sites . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
80,
83
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
150,
162
]
} |
( ii ) antisera prepared in balb/c mice against the balb/c sarcoma 1315 contained antibodies that reacted with a type-specific antigen of the 1315 mulv gp70 that is not found on other balb/c mulv . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
82,
92
]
} |
the stability of tubulins present in crude extracts of untransformed balb/c-3t3 mouse fibroblasts , chinese hamster lung cells , and various of their simian virus 40 transformants was assessed by measurement of their individual colchicine-binding decay rates . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
86,
97
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
121,
126
]
} |
the highest level of the internal 6-methyladenosine residues in simian virus 40 nuclear rna was located on the l strand within a fragment from 83 to 0.0 map units and in rna transcripts from the e strand within a fragment from 37 to 67 map units . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
80,
91
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
170,
173
]
} |
the effect of the nucleoside analog 9- ( 2-hydroxyethoxymethyl ) guanine ( acycloguanosine ) on herpes simplex virus type 1 dna synthesis was examined . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
65,
72
]
} | {
"id": "C0001367",
"name": "acycloguanosine",
"pos": [
75,
90
]
} |
studies using partially purified enzymes revealed that the triphosphate of this compound inhibited the virus-induced dna polymerases ( dna nucleotidyltransferases ) to a greater degree than the dna polymerase of the host cell , that the inhibition was dependent upon the base composition of the template , and that the triphosphate was a better substrate for the virus-induced polymerases than for the alpha cellular dna polymerases . | NA | {
"id": "C0012882",
"name": "dna nucleotidyltransferases",
"pos": [
135,
162
]
} | {
"id": "C0012892",
"name": "dna polymerase",
"pos": [
417,
431
]
} |
because da- and alpha-blockers produced an increase in the accumulation of da , dopaminergic and/or alpha-adrenergic mechanisms probably exist in the exocrine pancreas of the rat and these mechanisms modify the enzyme secretion . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
8,
10
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
80,
92
]
} |
angiotensin ii receptors from rat adrenal cortex and myometrium were studied with the use of tritiated angiotensin under conditions where the sensitivity of the target organs for angiotensin ii is modified . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
0,
11
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
179,
193
]
} |
glycoside concentrations in plasma and various tissues of dogs were determined after a single and repeated intravenous administration of tritium-labeled digoxin and beta-methyldigoxin . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
153,
160
]
} | {
"id": "C0025132",
"name": "beta-methyldigoxin",
"pos": [
165,
183
]
} |
lidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts , but caused interval-related increases in conduction time of extrasystoles in the range of 250 -- 400 msec , here called mid-range extrasystoles ( mre ) . | NA | {
"id": "C0151636",
"name": "ventricular",
"pos": [
41,
52
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
296,
309
]
} |
however , lidocaine and tocainide were also found to be arrhythmogenic when extrasystoles were introduced , after acute coronary occlusion , in those animals in which such occlusion alone did not allow demonstration of arrhythmias due to extrasystoles . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
219,
230
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
238,
251
]
} |
our results indicate that the addition of an aminosugar group to the genin further increased potency over that observed with the addition of a single neutral sugar and prolonged the duration of activity in failing myocardial tissue . | NA | {
"id": "C0002531",
"name": "aminosugar",
"pos": [
45,
55
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
158,
163
]
} |
by this method , lipopolysaccharide-protein ( endotoxin ) complexes associated with alkaline phosphatase activities were released from both strain 08 and strain bizio . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
17,
35
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
46,
55
]
} |
influence of temperature on ionic sparing effect and cell-associated cations in the moderate halophile , micrococcus varians var . halophilus . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
28,
33
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
69,
76
]
} |
the hsv dna sequences in the nuclei of paa treated cells at 24 hr post infection banded at the same density as free hsv dna ( 1.725 g/cm3 ) , but a significant amount of viral dna sequences were detected in the regions of cell dna ( 1.700 g/cm3 ) as well as in the intermediate fractions as determined by hybridization with 3h hsv complementary rna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
10,
11
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
227,
230
]
} |
when the dna from the nuclei of paa treated cells was analyzed in an alkaline glycerol gradient , more than 95 % of the viral dna sequences were found in the free viral dna fractions . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
9,
12
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
163,
172
]
} |
since the viral and cellular hybrid dna represented approximately 33 % of the total viral dna sequences , it is concluded that some of the hsv dna sequences in paa treated , infected cells are associated with cell dna by alkali-labile bonds . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
84,
93
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
214,
217
]
} |
infections with nematode larvae as with larva migrans and trichinoses are more problematic therapeutically because the anthelmintics are directed principally against the adult worms . | NA | {
"id": "C0027583",
"name": "infections",
"pos": [
0,
10
]
} | {
"id": "C0023048",
"name": "larva migrans",
"pos": [
40,
53
]
} |
infections with nematode larvae as with larva migrans and trichinoses are more problematic therapeutically because the anthelmintics are directed principally against the adult worms . | NA | {
"id": "C0027583",
"name": "infections",
"pos": [
0,
10
]
} | {
"id": "C0018889",
"name": "worms",
"pos": [
176,
181
]
} |
establishing a condition suitable for operation and referring the patient to the surgeon before the gallbladder disease has become a biliary tract disease and the operative chances are destroyed by serious complications . | NA | {
"id": "C0016977",
"name": "gallbladder",
"pos": [
100,
111
]
} | {
"id": "C0005424",
"name": "biliary tract disease",
"pos": [
133,
154
]
} |
fibronectin ( lets protein ) was found in considerably higher amount in medium from normal rat embryo fibroblasts than in that from transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
144,
149
]
} |
unlike the normal fibroblastic cells b-41fb derived from bone , all neoplastic cell lines tested possess the capability to inhibit embryonic nr cell aggregation significantly . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
11,
17
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
18,
30
]
} |
the following enzymatic activities were measured in serum of patients with benign and malignant ovarian tumors before treatment : alkaline and acid phosphatases , aspartyl ( aspat ) and alanyl ( alat ) aminotransferases , leucyl ( lap ) and alanyl ( aap ) aminopeptidases , lactate dehydrogenase ( ldh ) , gamma-glutamyl transpeptidase , cathepsin , alkaline ribonuclease ( rnase ) and beta-glucuronidase . | NA | {
"id": "C0054943",
"name": "aap",
"pos": [
250,
253
]
} | {
"id": "C0002570",
"name": "aminopeptidases",
"pos": [
256,
271
]
} |
unlike the other macromolecules under investigation ( polyvinylpyrrolidone , methylcellulose , polyvinyl alcohol ) , sodium carboxymethylcellulose acts on streptomycin sulphate , which leads to isolable precipitates . | NA | {
"id": "C0025729",
"name": "methylcellulose",
"pos": [
77,
92
]
} | {
"id": "C0037487",
"name": "sodium carboxymethylcellulose",
"pos": [
117,
146
]
} |
by equilibrium dialysis in electrolyte-free and electrolyte-containing solutions , the interaction was characterized in more detail and described by donnan curves . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
27,
38
]
} | {
"id": "C0308944",
"name": "electrolyte",
"pos": [
48,
59
]
} |
a comparison of the thermal behavior of protein-free dna isolated from nucleosomes with that of dna bound to histones indicates that dna segments in nucleosomes take on several conformational states . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
133,
136
]
} |
an about 10 cm length of column packed with 100 g of copper oxide was examined on the conversion ratios of hydrogen and tritium into water . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
107,
115
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
120,
127
]
} |
it was observed that at column temperatures lower than 450 degrees c the conversion ratio of tritium in the waste gas into water is considerably smaller than that of hydrogen of 0.1 % in argon . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
93,
100
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
166,
174
]
} |
a certain proportion of radioactivity administered as glycerol appeared in plasma lipids , mainly in the vldl glyceride glycerol fraction , although when ( u-14c ) -glycerol was the substrate , a considerable portion also appeared in the esterified fatty acids of these lipoproteins . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
105,
109
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
270,
282
]
} |
[ bacteriuria , urinary infection and pyelonephritis . critical analysis of the results obtained between the years 1958 and 1978. part i ] . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
2,
13
]
} | {
"id": "C0042029",
"name": "urinary infection",
"pos": [
16,
33
]
} |
in contrast , at such concentrations nalidixic acid enhanced the adhesion of this bacterial strain , and other antibiotics-e.g. , penicillin g , ampicillin , mecillinam , cephacetrile , cephalexin , cefotaxime , chloramphenicol , and streptomycin-did not affect its adhesiveness . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
130,
142
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
145,
155
]
} |
in contrast , at such concentrations nalidixic acid enhanced the adhesion of this bacterial strain , and other antibiotics-e.g. , penicillin g , ampicillin , mecillinam , cephacetrile , cephalexin , cefotaxime , chloramphenicol , and streptomycin-did not affect its adhesiveness . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
171,
183
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
199,
209
]
} |
repeated transfers to media containing increasing concentrations of gentamicin resulted in the development of complete resistance to all aminoglycosides without the concurrent development of any demonstrable new enzyme activity . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
68,
78
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
137,
152
]
} |
with repeated transfers in drug-free medium , a complete reversal to susceptibility to gentamicin , but not to other aminoglycosides , was obtained for strains that had previously been transferred in sub-mics of gentamicin , whereas strains that had been transferred in increasing concentrations of gentamicin did not revert to their original sensitivity to aminoglycosides despite repeated transfers in drug-free medium . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
87,
97
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
358,
373
]
} |
in a randomized double-blind cross-over study , 19 young women received iron tablets ( neo-fer ) containing 0.20 g ferrous fumarate ( 60 mg fe++ ) , and placebo tablets , twice daily during two periods of 8 weeks each . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
72,
76
]
} | {
"id": "C0060276",
"name": "ferrous fumarate",
"pos": [
115,
131
]
} |
spleen cells from mice exposed to 500 rad sublethal whole-body irradiation before immunization with 100 x 10 ( 6 ) allogeneic spleen cells exhibited an enhanced cytolytic t-lymphocyte ( ctl ) activity . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
115,
125
]
} |
although these spleen cells were perfectly capable of mounting a secondary response upon restimulation in vitro with intact allogeneic spleen cells , they were no longer capable of responding to subcellular alloantigen preparations . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
124,
134
]
} |
among patients consecutively admitted to a coronary care unit ( ccu ) without a subsequent diagnosis of acute myocardial infarction ( ami ) , a subgroup fo unstable angina was selected , defined as continued episodes of angina at rest during a 48-hour period , despite medical treatment in the ccu . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
156,
171
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
220,
226
]
} |
it is concluded that the combination of recent onset of angina and continued episodes of angina at rest , despite medical treatment , selects a high risk subgroup of unstable angina . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
56,
62
]
} | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
166,
181
]
} |
the steal has been associated with cerebral symptoms indicating vertebrobasilar ischaemia , the subclavian steal syndrome . | NA | {
"id": "C0042568",
"name": "vertebrobasilar ischaemia",
"pos": [
64,
89
]
} | {
"id": "C0038531",
"name": "subclavian steal",
"pos": [
96,
112
]
} |
the inhibition of cell duplication by many lipophilic acids was measured in bacillus subtilis and in the following mammalian cell lines , the human epithelial-type cell lines hela , strain r and strain l-132 , the human fibroblast cell line va-13 , and the rat glial cell line c . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
220,
230
]
} |
twenty-five patients with an acute exacerbation of chronic bronchitis completed a double-blind trial of amoxycillin 1.5 g v ampicillin 4 g daily . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
104,
115
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} |
nuclear medicine departments with access to short-lived radionuclides from a nearby cyclotron can use the krypton isotope kr-81m . | NA | {
"id": "C0034595",
"name": "radionuclides",
"pos": [
56,
69
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
114,
121
]
} |
other cardiovascular diseases included pericardial disease , bacterial endocarditis , cor pulmonale , anaemic heart failure , congenital and syphilitic heart disease . | NA | {
"id": "C0034072",
"name": "cor pulmonale",
"pos": [
86,
99
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
152,
165
]
} |
a conclusion is drawn that in the in vivo and in vitro experiments there occurs phosphorylation of the total preparation of aminoacyl-trna synthetases and individual lysyl-trna synthetase . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
124,
150
]
} | {
"id": "C0024376",
"name": "lysyl-trna synthetase",
"pos": [
166,
187
]
} |
when adding pharmacopoeian alpha-tocopherylacetate , short-chain alpha-tocopherylacetate , alpha-tocopherylquinine , short-chain alpha-tocopherylquinone and alpha-tocopheronolactone to e-avitaminotic rations pharmacopoeian alpha-tocopherylacetate and alpha-tocopheronolactone manifest the highest e-vitamin activity in preventing encephalomalacia in chickens . | NA | {
"id": "C0078373",
"name": "tocopherylacetate",
"pos": [
33,
50
]
} | {
"id": "C0042874",
"name": "e-vitamin",
"pos": [
297,
306
]
} |
when adding pharmacopoeian alpha-tocopherylacetate , short-chain alpha-tocopherylacetate , alpha-tocopherylquinine , short-chain alpha-tocopherylquinone and alpha-tocopheronolactone to e-avitaminotic rations pharmacopoeian alpha-tocopherylacetate and alpha-tocopheronolactone manifest the highest e-vitamin activity in preventing encephalomalacia in chickens . | NA | {
"id": "C1999896",
"name": "alpha",
"pos": [
27,
32
]
} | {
"id": "C0042874",
"name": "e-vitamin",
"pos": [
297,
306
]
} |
changes of free amino acid content in blood plasma from sheep and hens infected with s. abortus ovis and p. multocida or treated with purified lipopolysaccharides ( endotoxins ) of the respective agent , were studied . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
143,
162
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
165,
175
]
} |
it was established that the course of nematodirosis is typical with well expressed clinical symptoms in group iii -- diarrhoea , loss of appetite , nervous symptoms , oligochromemia , erythropaenia , leucocytosis , lymphocytosis , eosinophyly , acidosis , reduced carotene and total protein . | NA | {
"id": "C0023518",
"name": "leucocytosis",
"pos": [
200,
212
]
} | {
"id": "C0024282",
"name": "lymphocytosis",
"pos": [
215,
228
]
} |
the nad+-dependent adh ( adh i ) , with a molecular weight of 240,000 daltons , reacts more intensively with long-chain alcohols ( octanol ) than with short-chain alcohols ( methanol , ethanol ) . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
120,
128
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
174,
182
]
} |
the nad+-dependent adh ( adh i ) , with a molecular weight of 240,000 daltons , reacts more intensively with long-chain alcohols ( octanol ) than with short-chain alcohols ( methanol , ethanol ) . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
174,
182
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
185,
192
]
} |
the nadp+-dependent alcohol dehydrogenases ( adh ii -- iv ) react with methanol , ethanol and octanol with different intensity . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
71,
79
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
82,
89
]
} |
determination of the polysaccharide contents and structural studies on the mannan by acetolysis and permethylation analysis shows an altered polysaccharide biosynthesis of the osmotic-sensitive mutant vy 1160 of saccharomyces cerevisiae s 288 . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
21,
35
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
75,
81
]
} |
selected parameters of clinical chemistry ( glucose , lactic dehydrogenase , aspartal-aminotransferase , alanine aminotransferase , alkaline phosphatase , protein , albumine , creatinine , butanol extractable iodine , ferrum ) show under therapeutic conditions no influences of ascorbic acid , which can lead to diagnostic or therapeutic false interpretations . | NA | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
86,
102
]
} | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
105,
129
]
} |
selected parameters of clinical chemistry ( glucose , lactic dehydrogenase , aspartal-aminotransferase , alanine aminotransferase , alkaline phosphatase , protein , albumine , creatinine , butanol extractable iodine , ferrum ) show under therapeutic conditions no influences of ascorbic acid , which can lead to diagnostic or therapeutic false interpretations . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
155,
162
]
} | {
"id": "C0001924",
"name": "albumine",
"pos": [
165,
173
]
} |
the protease from fasciola hepatica belongs to the carboxyl group of proteases and probably plays an important role in helminth nutrition . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
4,
12
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
69,
78
]
} |
thus , in patients with persistent gh deficiency additional multiple disturbances of the hypothalamic-pituitary function often appeared whereas in most patients with transitory gh deficiency the combined pituitary test was normal at the reinvestigation . | NA | {
"id": "C0020635",
"name": "deficiency",
"pos": [
38,
48
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
204,
213
]
} |
intravenous infusion of noradrenaline or adrenaline markedly reduced rcbf ( by 22-48 % of control levels ) in all regions except thalamus , mesencephalon , and pons . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
24,
37
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
41,
51
]
} |
the noradrenaline-induced reduction was blocked , and the effect of adrenaline reversed , after pretreatment with the alpha-receptor antagonist , phentolamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
4,
17
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
68,
78
]
} |
the proteins in the cryoprecipitates that migrate electrophorectically with the alpha- , beta- and gamma-globulins represent immunoglobulins and , perhaps , some fdp . | NA | {
"id": "C0017007",
"name": "gamma-globulins",
"pos": [
99,
114
]
} | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
125,
140
]
} |
dull pink globules were found within the epidermis in 65 % of junctional , 75 % of compound , and 25 % of intradermal types of spitz 's nevi ( the nevi of large spindle and/or epithelioid cells ) . | NA | {
"id": "C0206737",
"name": "intradermal",
"pos": [
106,
117
]
} | {
"id": "C0027960",
"name": "nevi",
"pos": [
147,
151
]
} |
( 3 ) most types of tumor are suitable for analysis , but when biopsies contain a high proportion of stromal fibroblasts , there is a real danger that after about 20 days in culture the normal cells will overgrow the tumor cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
186,
198
]
} |
there were 22 patients -- 10 with plexiform neurofibromas , 3 with neurofibromas , 2 with esthesioneuroblastomas , 2 with neurilemmomas , 1 with neurogenous sarcoma , and 4 with neuroblastomas who presented with a mass in the head and neck . | NA | {
"id": "C0206717",
"name": "esthesioneuroblastomas",
"pos": [
90,
112
]
} | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
178,
192
]
} |
germfree and conventional-flora sprague-dawley rats were fed sodium nitrate or sodium nitrite in their drinking water ( 1,000 microgram/ml ) , and various organs , tissues , and sections of the intestinal tract were assayed for nitrate ( no3- ) and nitrite ( no2- ) by a spectrophotometric method . | NA | {
"id": "C0074748",
"name": "sodium nitrate",
"pos": [
61,
75
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
228,
235
]
} |
germfree and conventional-flora sprague-dawley rats were fed sodium nitrate or sodium nitrite in their drinking water ( 1,000 microgram/ml ) , and various organs , tissues , and sections of the intestinal tract were assayed for nitrate ( no3- ) and nitrite ( no2- ) by a spectrophotometric method . | NA | {
"id": "C0037532",
"name": "sodium nitrite",
"pos": [
79,
93
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
249,
256
]
} |
in dogs , the metabolism of primidone and the pharmacokinetics of the drug itself as well as its metabolites phenobarbital and phenylethylmalonic acid diamide ( pema ) was followed after single oral doses of 30 mg/kg ( 0.14 mmole/kg ) . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
28,
37
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
109,
122
]
} |
in mice , the anticonvulsant potency of the 3 drugs was determined : elevations of the electroconvulsant threshold by 40 v were produced by 0.01 mmole/kg of phenobarbital , 0.017 mmole/kg of primidone or 0.37 mmole/kg of pema . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
157,
170
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
191,
200
]
} |
taking the anticonvulsant potency of the 3 drugs into consideration , phenobarbital is responsible for more than 85 % of the total anticonvulsant activity during continued medication of primidone . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
70,
83
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
186,
195
]
} |
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