text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
during glucose infusion ( 33 mumol/kg.min for 90 min ) , blood glucose reached significantly higher levels in the uremic patients than in controls ( p less than 0.02 ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
7,
14
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
57,
70
]
} |
ct-related peptides induce a significant chemotactic response , and the potency order is : salmon ct greater than human ct greater than ct much greater than carbo-ct ; | NA | {
"id": "C0073994",
"name": "salmon ct",
"pos": [
91,
100
]
} | {
"id": "C0006668",
"name": "ct",
"pos": [
163,
165
]
} |
the chemotactic response of monocytes obtained from patients chronically treated with either salmon ct or carbo-ct is impaired , thus suggesting a phenomenon of down-regulation of a common receptor on monocytes . | NA | {
"id": "C0073994",
"name": "salmon ct",
"pos": [
93,
102
]
} | {
"id": "C0006668",
"name": "ct",
"pos": [
112,
114
]
} |
since conditioned medium from these cartilages contains both igf-i-like peptides and igf-binding proteins such as bp-25 , we suggest that the igf-binding proteins present may act to down-regulate the growth-promoting effects of the local igf peptides . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
61,
66
]
} | {
"id": "C0037657",
"name": "growth",
"pos": [
200,
206
]
} |
the release into the medium of the cortisol precursors deoxycortisol , 17-hydroxyprogesterone , and progesterone showed that the four autonomous nodules were characterized by a significantly higher deoxycortisol/cortisol ratio in the medium ( p less than 0.01 ) , suggesting a relative blockade of 11 beta-hydroxylase in these adrenal adenomas . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
71,
93
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
100,
112
]
} |
twenty-two apparently euthyroid patients with endocrine ophthalmopathy not associated with goiter , antithyroid microsomal or antithyroglobulin antibodies , or overt thyroid disease ( so-called ophthalmic graves ' disease ) were tested for subclinical hyperthyroidism or hypothyroidism . | NA | {
"id": "C0018021",
"name": "goiter",
"pos": [
91,
97
]
} | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
166,
181
]
} |
twenty-two apparently euthyroid patients with endocrine ophthalmopathy not associated with goiter , antithyroid microsomal or antithyroglobulin antibodies , or overt thyroid disease ( so-called ophthalmic graves ' disease ) were tested for subclinical hyperthyroidism or hypothyroidism . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
166,
181
]
} | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
271,
285
]
} |
to define the subcellular location ( s ) of the antigen ( s ) capable of binding with these antibodies , we have quantitated both antibody binding to various adrenal subcellular fractions and the adrenal autoantibody binding inhibition caused by each subcellular fraction . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
204,
216
]
} |
the antibody populations being investigated , however , should be distinguished from other autoantibodies which might be present in the patients ' serum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
91,
105
]
} |
t cell responses against intact , purified major myelin proteins ( myelin basic protein ( mbp ) and proteolipid protein ( plp ] , and against altered myelin constituents were readily demonstrable in sjl/j mice with r-eae , but were not detectable in sjl/j mice with tmev-induced demyelinating disease . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
49,
64
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
67,
87
]
} |
therefore , we have selected from a series of mab raised to ovine prolactin two antibodies ( 17d9 and 6f11 ) that react specifically with rat prolactin in immunocytochemical studies , whereas 6f11 also reacts strongly with rat prolactin by elisa and western blot analysis . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
46,
49
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
80,
90
]
} |
although decarboxylases , particularly ornithine decarboxylase , are of considerable importance in cell metabolism , it has been impossible to demonstrate their activity histochemically , as this depends on trapping carbon dioxide at neutral ph values . | NA | {
"id": "C0007054",
"name": "decarboxylases",
"pos": [
9,
23
]
} | {
"id": "C0029282",
"name": "ornithine decarboxylase",
"pos": [
39,
62
]
} |
the assay uses a sequence of enzyme reactions that yields two moles of nadh for each mole of the uridine-5'-diphosphate ( udp ) released during transfer of a monosaccharide from a udp sugar to an acceptor . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
158,
172
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
184,
189
]
} |
to study the effect of endotoxin ( lps ) on the basal and chemotactic peptide , formyl-methionyl-leucyl-phenylalanine ( fmlp ) -induced alterations in neutrophil cytoskeleton , we purified ( greater than 98 % ) lps-free neutrophils ( lps- less than 10 pg/ml lps ) , compared their cytoskeletal organization to that of circulating neutrophils , and examined the effect of lps exposure on the basal and fmlp-induced change in the cytoskeleton as reflected by f-actin content and distribution . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
23,
32
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
371,
374
]
} |
phorbol-12-myristate , 13-acetate ( pma ) , a phorbol ester that acts like dag to activate protein kinase c , markedly enhanced lysis of a susceptible target cell by rnk . | NA | {
"id": "C0039654",
"name": "pma",
"pos": [
36,
39
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
46,
59
]
} |
acute , fulminant bladder hemorrhage usually is seen at tertiary care centers in which cancer patients are treated with oxazaphosphorine alkylating agents , particularly cyclophosphamide and isophosphamide . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
170,
186
]
} | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
191,
205
]
} |
in all cases the diagnosis should be reserved until more common causes of hematuria , such as bacterial or fungal infection , stones , cysts or tumors , have been ruled out . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
135,
140
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
144,
150
]
} |
human papillomavirus type 6 messenger ribonucleic acid was demonstrated within biopsy specimens using tritium-labeled single-stranded antisense ribonucleic acid probes . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
28,
54
]
} | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
144,
160
]
} |
there were three groups , membranes that were treated only with the irrigating solution , membranes pretreated with protamine , and membranes pretreated with protamine plus pps . | NA | {
"id": "C0033603",
"name": "protamine",
"pos": [
116,
125
]
} | {
"id": "C0033602",
"name": "protamine",
"pos": [
158,
167
]
} |
hospitalization is indicated whenever underlying infectious stone disorders are suspected ( associated urinary tract infection or infected calculi ) . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
49,
59
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
103,
126
]
} |
in both groups plasma catecholamine levels increased 5 minutes after institution of bypass ( epinephrine 176 +/- 56 to 611 +/- 108 pg/ml and norepinephrine 231 +/- 48 to 518 +/- 100 pg/ml in group a ; epinephrine 168 +/- 40 to 444 +/- 100 pg/ml and norepinephrine 162 +/- 44 to 267 +/- 52 pg/ml in group b ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
249,
263
]
} |
the maximum catecholamine level was measured between the end of bypass and 2 hours after the end of bypass ( epinephrine 1489 +/- 169 pg/ml and norepinephrine 1542 +/- 108 pg/ml in group a ; epinephrine 990 +/- 134 pg/ml and norepinephrine 934 +/- 197 pg/ml in group b ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
109,
120
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
225,
239
]
} |
triiodothyronine had no influence on triglyceride synthesis of normal cell lines and of cells derived from patients with secondary hypertriglyceridemia , whereas fibroblasts from endogenous type iv patients showed higher rates of triglyceride synthesis under identical conditions . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
162,
173
]
} |
diabetes is associated with a fall in serum insulin-like growth factor-i ( igf-1 ) and a rise in somatomedin inhibitor , a circulating factor ( s ) of approximately 30,000 mw that is released by the liver and can antagonize both somatomedin and insulin action . | NA | {
"id": "C0021665",
"name": "igf-1",
"pos": [
75,
80
]
} | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
229,
240
]
} |
measurements were made in 49 healthy men before and after three weeks of abstinence from alcohol and after consumption of one or three 12-ounce cans of beer per day . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
89,
96
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
152,
156
]
} |
we found that 1 ) there are detectable human igf i- and ii-like substances in all extracts , 2 ) igf values obtained in the skeletal extracts were not caused by binding protein artifacts , 3 ) in general there is more igf ii than igf i , and 4 ) the skeletal tissue levels of the igfs are comparable with their respective serum levels . | NA | {
"id": "C0021665",
"name": "igf i",
"pos": [
45,
50
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
280,
284
]
} |
we found that 1 ) there are detectable human igf i- and ii-like substances in all extracts , 2 ) igf values obtained in the skeletal extracts were not caused by binding protein artifacts , 3 ) in general there is more igf ii than igf i , and 4 ) the skeletal tissue levels of the igfs are comparable with their respective serum levels . | NA | {
"id": "C0021666",
"name": "igf ii",
"pos": [
218,
224
]
} | {
"id": "C0037657",
"name": "igfs",
"pos": [
280,
284
]
} |
however , deletion of this site did not affect stimulation by the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
66,
79
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
80,
116
]
} |
in contrast , if bamhi-cleaved ptkb8 dna was cotransformed into cells along with a circular dna molecule containing a tk gene deleted only at its 3 ' end or only at its 5 ' end ( mp10tk delta 3 ' or mp10tk delta 5 ' ) , then the efficiency of recombination could be more than 4 orders of magnitude higher than it was with circular mp10tk delta 3 ' delta 5 ' dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
37,
40
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
322,
330
]
} |
these transcripts can potentially generate four protein isoforms that differ in their n-terminal 16 to 21 amino acids but are identical in the remainder of the protein , including the rnp consensus motif domain and the glycine-rich domain characteristic of the mammalian a1 protein . | NA | {
"id": "C0597298",
"name": "protein",
"pos": [
48,
55
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
274,
281
]
} |
these transcripts can potentially generate four protein isoforms that differ in their n-terminal 16 to 21 amino acids but are identical in the remainder of the protein , including the rnp consensus motif domain and the glycine-rich domain characteristic of the mammalian a1 protein . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
106,
117
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
219,
226
]
} |
we have previously reported that phorbol esters , e.g. , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , stimulate human sh-sy5y neuroblastoma cells to neuronal differentiation , as monitored by morphological , biochemical , and functional differentiation markers . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
33,
47
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
57,
93
]
} |
mv5 mrna exhibited the increased stability indicative of positive regulation when the estradiol-estrogen receptor complex was present and was not destabilized by unliganded estrogen receptor . | NA | {
"id": "C0034803",
"name": "estradiol",
"pos": [
86,
95
]
} | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
173,
190
]
} |
cotransfection of tax with the ras oncogene into rat embryo fibroblasts gave rise to foci of transformed cells that were highly tumorigenic in nude mice . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
105,
110
]
} |
all three variant cell lines failed to activate nf-kappa b when induced with lps or the phorbol ester 12-o-tetradecanoylphorbol 13-acetate . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
88,
101
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
102,
138
]
} |
adrenomyeloneuropathy is the name given to a biochemically identical but milder and more slowly progressive variant of adrenoleukodystrophy that affects young adults , in whom adrenal insufficiency may long precede nervous system dysfunction . | NA | {
"id": "C0162309",
"name": "adrenoleukodystrophy",
"pos": [
119,
139
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
176,
197
]
} |
because of a preponderance of male patients among a group of patients with the onset of adrenal failure in childhood , we questioned whether this condition might be the initial manifestation of adrenomyeloneuropathy . | NA | {
"id": "C0001623",
"name": "adrenal failure",
"pos": [
88,
103
]
} | {
"id": "C0162309",
"name": "adrenomyeloneuropathy",
"pos": [
194,
215
]
} |
after consuming comparable amounts of ethanol , women have higher blood ethanol concentrations than men , even with allowance for differences in size , and are more susceptible to alcoholic liver disease . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
} | {
"id": "C0684262",
"name": "blood ethanol",
"pos": [
66,
79
]
} |
the first-pass metabolism was determined on the basis of the difference in areas under the curves of blood alcohol concentrations after intravenous and oral administration of ethanol ( 0.3 g per kilogram of body weight ) . | NA | {
"id": "C0684262",
"name": "in",
"pos": [
36,
38
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
175,
182
]
} |
the case of a middle-aged woman with a cavernous hemangioma of the right cavernous sinus who showed ipsilateral hemianopsia associated with contralateral blindness caused by left retrobulbar optic neuritis is presented . | NA | {
"id": "C0018979",
"name": "hemianopsia",
"pos": [
112,
123
]
} | {
"id": "C0456909",
"name": "blindness",
"pos": [
154,
163
]
} |
in 34 % of patients the iccaans were asymptomatic at diagnosis , 36 % were associated with headache , and 57 % had associated signs or symptoms of mass effect including sixth nerve paresis ( 43 % ) , trigeminal pain or sensory loss ( 32 % ) , third nerve paresis ( 20 % ) , decreased vision or visual field cut ( 18 % ) , fourth nerve paresis ( 16 % ) , and horner 's syndrome ( 7 % ) . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
91,
99
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
211,
215
]
} |
consuming a diet in which fats were present only at levels sufficient to satisfy the threshold requirement of essential fatty acids , 4.5-7.5 % of the total calories , or alternatively where dietary fat represented greater than 67 % of the total calories consumed , did not significantly alter the tendency for breast tumor development . | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
26,
30
]
} | {
"id": "C0012171",
"name": "dietary fat",
"pos": [
191,
202
]
} |
sonograms and radiographs of the lumbar spine in 51 fetuses and neonates with thanatophoric dwarfism , achondroplasia , and osteogenesis imperfecta type ii were retrospectively evaluated . | NA | {
"id": "C0039743",
"name": "thanatophoric dwarfism",
"pos": [
78,
100
]
} | {
"id": "C0001080",
"name": "achondroplasia",
"pos": [
103,
117
]
} |
the severe platyspondyly of thanatophoric dysplasia and the milder platyspondyly of achondroplasia were detected by about 20 menstrual weeks . | NA | {
"id": "C0039743",
"name": "thanatophoric dysplasia",
"pos": [
28,
51
]
} | {
"id": "C0001080",
"name": "achondroplasia",
"pos": [
84,
98
]
} |
the lipophilic nature of both heptachlor and heptachlor epoxide results in the potential for significant bioaccumulation in all lipid-type compartments in the environment . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
30,
40
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
45,
63
]
} |
despite the knowledge that cadmium is toxic , only 20 human cases of poisoning via ingestion were recorded prior to 1941 , whereas in the ensuing five-year period more than 680 cases of cadmium poisonings from accidental oral ingestion of this metal were documented . | NA | {
"id": "C0032343",
"name": "poisoning",
"pos": [
69,
78
]
} | {
"id": "C0006635",
"name": "cadmium poisonings",
"pos": [
186,
204
]
} |
some of these effects have also been observed in human after accidental exposures to cadmium oxide fumes and are characteristic of the syndrome described in japan as itai itai disease in which ingestion of cadmium is the inciting chemical . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
135,
143
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
176,
183
]
} |
in 1943 , dragstedt , in the united states , reported the cure of duodenal peptic ulcer disease by supradiaphragmatic vagotomy . | NA | {
"id": "C0013289",
"name": "the",
"pos": [
25,
28
]
} | {
"id": "C0030920",
"name": "peptic ulcer",
"pos": [
75,
87
]
} |
mature dna from phage t3 or t7 is a linear duplex dna with direct repeats at its ends known as `` '' terminally redundant sequences . '' '' | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
7,
10
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
118,
119
]
} |
however , amino acid differences in the glycoprotein of a 1983 isolate from an enzootic region of georgia resulted in major antigenic deficiencies in epitopes v , vi , and vii as determined by western blotting and neutralization of infectivity with epitope-specific mabs . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
124,
133
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
249,
256
]
} |
administration of noninternal image monoclonal anti-idiotypic antibodies induces idiotype-restricted responses specific for human immunodeficiency virus envelope glycoprotein epitopes . | NA | {
"id": "C0021013",
"name": "idiotype",
"pos": [
81,
89
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
175,
183
]
} |
a mouse monoclonal anti-idiotypic antibody ( anti-id ) , designated mc1 , was generated against chimpanzee antibodies specific for a synthetic peptide corresponding to a native epitope associated with gp41 of human immunodeficiency virus ( hiv ) . | NA | {
"id": "C0021013",
"name": "id",
"pos": [
24,
26
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
177,
184
]
} |
together , these studies indicate that a mouse monoclonal anti-id of the ab-2 alpha class can induce an anti-hiv response specific for a gp41 epitope defined by a synthetic peptide , which does not cross species barriers . | NA | {
"id": "C0021013",
"name": "id",
"pos": [
63,
65
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
142,
149
]
} |
an often-unsuspected complication is metastasis to the gastrointestinal tract , which leads to bowel obstruction or intussusception . | NA | {
"id": "C0021843",
"name": "bowel obstruction",
"pos": [
95,
112
]
} | {
"id": "C0021933",
"name": "intussusception",
"pos": [
116,
131
]
} |
these results suggest that a complete lipid and lipoprotein analysis be obtained in all patients with cad , irrespective of the plasma ( or serum ) total cholesterol level . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
38,
43
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
48,
59
]
} |
accordingly , forearm blood flow , forearm vascular resistance , mean and phasic arterial pressure , cardiac output and plasma norepinephrine , epinephrine and dopamine were measured during atrial , ventricular and v-a pacing at a cycle length of 600 ms ( 100 beats/min ) before and after regional alpha blockade with intraarterial phentolamine in 16 patients with a left ventricular ejection fraction greater than 35 % and little or no symptoms of congestive heart failure . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
127,
141
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
144,
155
]
} |
before exercise , subjects underwent comprehensive physiologic and behavioral assessments , including graded exercise treadmill testing with direct measurement of oxygen consumption ( vo2 ) and measurement of cardiovascular ( heart rate , systolic and diastolic blood pressure and rate pressure product ) and neuroendocrine ( epinephrine and norepinephrine ) responses to mental arithmetic . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
326,
337
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
342,
356
]
} |
the early manifestations of intraabdominal inflammation or bleeding in patients undergoing capd depend on the pathological process , its access to the peritoneal cavity , and whether generalized bacterial peritonitis supervenes to obscure helpful physical findings . | NA | {
"id": "C0021368",
"name": "inflammation",
"pos": [
43,
55
]
} | {
"id": "C0030660",
"name": "pathological process",
"pos": [
110,
130
]
} |
the early manifestations of intraabdominal inflammation or bleeding in patients undergoing capd depend on the pathological process , its access to the peritoneal cavity , and whether generalized bacterial peritonitis supervenes to obscure helpful physical findings . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
59,
67
]
} | {
"id": "C0030660",
"name": "pathological process",
"pos": [
110,
130
]
} |
endocrine tissues with variable immunoreactivities for chromogranin a protein , such as small-cell lung carcinomas , neuroblastomas , insulinomas , and parathyroid adenomas , expressed the mrna for chromogranins a and b in most cells . | NA | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
55,
69
]
} | {
"id": "C0008586",
"name": "chromogranins",
"pos": [
198,
211
]
} |
these results indicate that ish can be used to detect chromogranins a and b in endocrine tissues with radioactive and biotinylated oligonucleotide probes and that the mrnas for chromogranin a and b are demonstrable in some tumors even when the chromogranin proteins can not be detected by immunohistochemistry . | NA | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
177,
191
]
} | {
"id": "C0008586",
"name": "chromogranin",
"pos": [
244,
256
]
} |
eighteen cases of malignant hemangioendothelioma ( mhe ) of the thyroid and 16 cases of undifferentiated thyroid carcinoma were investigated immunohistochemically with antibodies against endothelial cell specific markers ( factor viii-related antigen , bma 120 , blood group isoantigens , ulex europaeus agglutinin i ) , thyroglobulin , and the intermediate filament proteins vimentin and cytokeratin . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
345,
375
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
376,
384
]
} |
eighteen cases of malignant hemangioendothelioma ( mhe ) of the thyroid and 16 cases of undifferentiated thyroid carcinoma were investigated immunohistochemically with antibodies against endothelial cell specific markers ( factor viii-related antigen , bma 120 , blood group isoantigens , ulex europaeus agglutinin i ) , thyroglobulin , and the intermediate filament proteins vimentin and cytokeratin . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
345,
375
]
} | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
389,
400
]
} |
they will apply the latest therapeutic and diagnostic tools to give optimum care to patients suffering from vascular disease and associated medical disorders such as hyperlipidemia , hypertension , and hypercoagulopathy ; | NA | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
108,
124
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
183,
195
]
} |
forty-nine patients had nonsquamous cell malignancies : 12 ( 25 % ) sarcoma , 10 ( 20 % ) adenoid cystic carcinoma , 9 ( 18 % ) adenocarcinoma , 9 ( 18 % ) lymphoma , and 9 ( 18 % ) miscellaneous tumors . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinoma",
"pos": [
90,
114
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
128,
142
]
} |
these observations , together with those previously reported , support the conclusion that the multilobated b-cell variant of non-hodgkin 's lymphoma behaves in a fashion similar to that of the intermediate-grade , diffuse , large-cell non-hodgkin 's lymphomas . | NA | {
"id": "C0079731",
"name": "b-cell",
"pos": [
108,
114
]
} | {
"id": "C0079744",
"name": "large-cell",
"pos": [
225,
235
]
} |
these observations , together with those previously reported , support the conclusion that the multilobated b-cell variant of non-hodgkin 's lymphoma behaves in a fashion similar to that of the intermediate-grade , diffuse , large-cell non-hodgkin 's lymphomas . | NA | {
"id": "C0079731",
"name": "b-cell",
"pos": [
108,
114
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
236,
250
]
} |
abnormal mucin content , consisting of a predominance of sialomucin , was noted in transitional mucosa in 12 cases . | NA | {
"id": "C0026682",
"name": "mucin",
"pos": [
9,
14
]
} | {
"id": "C0074477",
"name": "sialomucin",
"pos": [
57,
67
]
} |
a 52-year-old man , suffering for years from malabsorption due to endemic sprue , developed progressive bowel dysfunction , ie , recurrent ileus and intestinal pseudo-obstruction . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
45,
58
]
} | {
"id": "C0021831",
"name": "bowel dysfunction",
"pos": [
104,
121
]
} |
a 52-year-old man , suffering for years from malabsorption due to endemic sprue , developed progressive bowel dysfunction , ie , recurrent ileus and intestinal pseudo-obstruction . | NA | {
"id": "C1258215",
"name": "ileus",
"pos": [
139,
144
]
} | {
"id": "C0021847",
"name": "intestinal",
"pos": [
149,
159
]
} |
human testicular germ cell tumors were studied immunohistochemically with the monoclonal antibody to the 54-kd keratin polypeptide ( keratin 7 ) to determine whether this antibody could be used selectively to identify trophoblastic cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
78,
97
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
171,
179
]
} |
secretion of tumor necrosis factor ( tnf ) /cachectin occurs during gram-negative bacterial sepsis in response to macrophage stimulation by lipopolysaccharide ( endotoxin ) and may play an early pivotal role in the subsequent host response . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
140,
158
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
161,
170
]
} |
monocytes from 11 trauma patients and 11 burn patients were suboptimally stimulated with interferon gamma and muramyl dipeptide , an analogue of bacterial wall products . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
18,
24
]
} | {
"id": "C0006434",
"name": "burn",
"pos": [
41,
45
]
} |
competing terms to designate disorders of speech and language were alalia ( used by jacques lordat ) , aphemia ( coined by broca ) , and the ultimately triumphant aphasia ( introduced by armand trousseau ) . | NA | {
"id": "C0037822",
"name": "disorders",
"pos": [
29,
38
]
} | {
"id": "C0003537",
"name": "aphasia",
"pos": [
163,
170
]
} |
with the conventional method , there were five failures to place the catheter and three incidents of bleeding , resulting in a total blood loss of 14 cc . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
101,
109
]
} | {
"id": "C0232100",
"name": "total blood loss of",
"pos": [
127,
146
]
} |
clues to the genetic origin of these antibodies are now being appreciated , but further study will be required to understand the defects responsible for the transformation of a natural autoantibody into a malignancy . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
37,
47
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
185,
197
]
} |
based on clinical symptoms , physiological findings , and an electroencephalogram taken at the time of seizure , the cataplexy of the right leg was diagnosed as epileptic seizures . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
103,
110
]
} | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
161,
179
]
} |
both polypeptides were completely retained in cytoskeletal protein-depleted membranes and could be removed by alkaline extraction , suggesting that both proteins contribute to the association of membrane proteins . | NA | {
"id": "C0010852",
"name": "cytoskeletal protein",
"pos": [
46,
66
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
204,
212
]
} |
both polypeptides were completely retained in cytoskeletal protein-depleted membranes and could be removed by alkaline extraction , suggesting that both proteins contribute to the association of membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
153,
161
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
195,
212
]
} |
candida albicans and human erythrocytes were treated with liposomal amphotericin b ( amb ) obtained by incubation of free amb with small unilamellar vesicles ( suv ) composed of unsaturated fatty acyl chains phosphatidylcholine ( egg-yolk pc ) . | NA | {
"id": "C1145701",
"name": "liposomal amphotericin",
"pos": [
58,
80
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
122,
125
]
} |
the liposomal preparations of amb were as active against fungi as amb in dimethylsulfoxide but less active ( internal k+ changes ) or inactive ( hemolysis ) against erythrocytes . | NA | {
"id": "C1145701",
"name": "liposomal",
"pos": [
4,
13
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
66,
69
]
} |
the variations of these levels with total amb concentration could therefore explain the increased selectivity of liposomal amb in toxicity against fungi and erythrocytes as compared to that of amb added as a solution in dimethylsulfoxide . | NA | {
"id": "C1145701",
"name": "liposomal amb",
"pos": [
113,
126
]
} | {
"id": "C0002679",
"name": "amb",
"pos": [
193,
196
]
} |
measurements of cytosolic glutathiones and bbm thiols also revealed that nm pretreatment shifted the cytosolic glutathione redox ( gsh/gssg ) and bbm thiol redox ( sh/ss ) toward more oxidized state . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
131,
134
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
135,
139
]
} |
on the other hand , s-100 , ovalbumin and albumin-stearate failed to bind pge2 , as shown by ultrafiltration , and also failed to enhance pge2 binding to the isolated adipocyte membranes . | NA | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
28,
37
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
42,
49
]
} |
finally it is shown that fatty acid binding protein ( fabp ) , a cytosolic protein which binds specifically pge1 but not pge2 , enhances pge1 and pge2 binding to isolated adipocyte membranes similarly to albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
44,
51
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
204,
211
]
} |
we have examined the effect of different anionic groups on the relative binding affinities of a series of homologous anionic polymers for bindin to determine the extent to which other charged moieties can substitute for sulfate . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
41,
48
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
220,
227
]
} |
pure 2-amino-3-ketobutyrate coa ligase from escherichia coli , which catalyzes the cleavage/condensation reaction between 2-amino-3-ketobutyrate ( the presumed product of the l-threonine dehydrogenase-catalyzed reaction ) and glycine + acetyl-coa , is a dimeric enzyme ( mr = 84,000 ) that requires pyridoxal 5'-phosphate as coenzyme for catalytic activity . | NA | {
"id": "C0034266",
"name": "pyridoxal",
"pos": [
299,
308
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
325,
333
]
} |
large decreases in gsh/gssg ratio preceded significant loss of protein thiols , but protein-glutathione mixed disulfides accounted for a minor percentage of the total protein thiol oxidized ( up to 20 % ) . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
23,
27
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
92,
103
]
} |
to determine the effects of this insert peptide , the structure of the rat alpha-crystallin aggregate and its subunits alpha a- , alpha ains- and alpha b-crystallin was studied using fluorescence spectra , partial urea dissociation , and lactoperoxidase-catalysed iodination of surface residues . | NA | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
75,
91
]
} | {
"id": "C0524533",
"name": "alpha b-crystallin",
"pos": [
146,
164
]
} |
the data suggest that all alpha-crystallin subunits occupy equivalent positions in the protein aggregate , and that the insert peptide merely elongates the connecting peptide between the putative amino- and carboxyl-terminal domain of the alpha a-crystallin subunit . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
32,
42
]
} | {
"id": "C0002257",
"name": "alpha",
"pos": [
239,
244
]
} |
fragile x syndrome is the most important x-linked etiology of mental retardation and developmental disability currently known . | NA | {
"id": "C0016667",
"name": "fragile x syndrome",
"pos": [
0,
18
]
} | {
"id": "C1136249",
"name": "x-linked",
"pos": [
41,
49
]
} |
no inhibition was detected for activated plasma thromboplastin antecedent ( factor xia ) , plasma kallikrein , or c1 esterase . | NA | {
"id": "C0015522",
"name": "plasma thromboplastin antecedent",
"pos": [
41,
73
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
76,
86
]
} |
mpo i was found to have lower activity with some substrates ( pyrogallol , guaiacol , potassium iodide [ ki ] ) , but similar activity to the other isoenzymes with 4-aminoantipyrine . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
4,
5
]
} | {
"id": "C0032831",
"name": "potassium iodide",
"pos": [
86,
102
]
} |
we used immunoelectron microscopy to study the in situ localization of the anca-antigen in normal human neutrophils and monocytes using immunoglobulin g ( igg ) from anca-positive patients and a mouse monoclonal antibody against the anca-antigen . | NA | {
"id": "C0103647",
"name": "antibody",
"pos": [
212,
220
]
} | {
"id": "C0004358",
"name": "anca",
"pos": [
233,
237
]
} |
our results demonstrate that anca-antigen is located in myeloperoxidase-containing granules of neutrophils and monocytes , and is packaged in the same granules as elastase and cathepsin g , the two previously identified serine proteases of myeloid leukocytes . | NA | {
"id": "C0030306",
"name": "elastase",
"pos": [
163,
171
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
220,
236
]
} |
among other cells studied , human fibroblasts also released tc ii into the incubation medium , while k562 human leukemia cells , arh-77 and hs sultan human plasma cell lines , and raji strain lymphoblasts did not . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} |
the erythrocyte membrane inhibitor of reactive lysis ( mirl ) is an 18-kd protein that controls complement-mediated hemolysis by restricting the activity of the membrane attack complex . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
96,
106
]
} | {
"id": "C0009545",
"name": "membrane attack complex",
"pos": [
161,
184
]
} |
interleukin-6 ( il-6 ) shares several biologic properties with il-1 , including hematopoietin-1 activity and stimulation of t cells . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
63,
67
]
} | {
"id": "C0600251",
"name": "hematopoietin-1",
"pos": [
80,
95
]
} |
multi-colony stimulating factor ( multi-csf , interleukin-3 , il-3 ) and granulocyte-csf ( g-csf ) administered concurrently as an intravenous ( iv ) injection induce a peripheral neutrophilia that is approximately additive in comparison with the neutrophilia induced by il-3 and g-csf individually . | NA | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
6,
31
]
} | {
"id": "C0021757",
"name": "il-3",
"pos": [
271,
275
]
} |
these data suggest that retroviral-mediated gene transfer of dhfrr cdna leads to a stable change in the phenotype of hematopoietic stem cells and progeny derived from those cells in vivo after bone marrow transplantation . | NA | {
"id": "C0018956",
"name": "hematopoietic stem cells",
"pos": [
117,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
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