text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
when reconstituted with tubulin lacking the beta iii isotype , the antibody causes the tubulin to polymerize into a polymer that is a microtubule in the presence of map 2 and a ribbon in the presence of tau . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
53,
60
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
67,
75
]
} |
among various 4-phosphate-containing inositol polyphosphates , the enzyme hydrolyzes only ins ( 1,3,4 ) p3 and inositol 3,4-bisphosphate ( ins ( 3,4 ) p2 ) , yielding inositol 1,3-bisphosphate and inositol 3-phosphate as products . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
16,
25
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
46,
60
]
} |
once the diagnosis of thoracic-outlet syndrome has been made , the possibility of an additional distal compression neuropathy should be investigated . | NA | {
"id": "C0039984",
"name": "thoracic-outlet syndrome",
"pos": [
22,
46
]
} | {
"id": "C0027743",
"name": "compression neuropathy",
"pos": [
103,
125
]
} |
although fibronectin fibrils were assembled on the surfaces of 5-d fibroblasts , few fibrils coursed between cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
67,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
109,
114
]
} |
these cells expressed fibronectin receptors , were embedded in a fibronectin matrix that appeared to connect fibroblasts to the matrix and to each other , and were coaligned across the wound . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} |
monoclonal antibodies revealed that this associated protein comprised the alpha 2 ( and possibly alpha 3 ) isoforms of the na , k-atpase catalytic subunit , but not alpha 1 . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
52,
59
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
107,
115
]
} |
the neural cell adhesion molecules l1 and n-cam have been suggested to interact functionally by formation of a complex between the two molecules ( kadmon , g. , a . | NA | {
"id": "C0950625",
"name": "neural cell adhesion molecules l1",
"pos": [
4,
37
]
} | {
"id": "C0282587",
"name": "n-cam",
"pos": [
42,
47
]
} |
plasma levels of cetp , apo a-i , lipids , and lipoproteins were measured in 50 normolipemic , healthy subjects of both sexes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
34,
40
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
47,
59
]
} |
in 29 other normolipemic subjects , where several apolipoproteins were also measured , significant correlations of cetp with apo a-i ( 0.41 ) , apo e ( 0.43 ) , and hdl-cholesterol ( 0.41 ) were observed , but there was no significant relationship between cetp and either apo a-ii , b , or d . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
50,
65
]
} | {
"id": "C0003595",
"name": "apo e",
"pos": [
144,
149
]
} |
cultured skin fibroblasts or lymphoblastoid cells from eight patients with clinical symptoms of prolidase deficiency were analyzed in terms of enzyme activity , presence of material crossreacting with specific antibodies , biosynthesis of the polypeptide , and mrna corresponding to the enzyme . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
44,
49
]
} |
il-1 alpha , il-1 beta , and tumor necrosis factor alpha ( tnf-alpha ) gene expression is induced by lps ( endotoxin ) in monocytes/macrophages and in some monocytic cell lines . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
101,
104
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
107,
116
]
} |
to approach these questions , we developed a sensitive enzyme-linked immunospot ( elispot ) assay to measure spontaneous secretion of antibody to single-stranded ( ss ) dna , double-stranded ( ds ) dna , tetanus toxoid , and polyclonal immunoglobulin ( ig ) by purified cd5+ and cd5- b cells of 15 sle patients and 15 healthy control subjects . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
146,
161
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
175,
190
]
} |
igg4 was prepared from sera of fs patients by anion exchange chromatography , and digested with pepsin to yield f ( ab ' ) 2 fragments . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
46,
51
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
125,
126
]
} |
dental calculus itself is not thought to affect gingival health , but its rough and porous surface retains plaque better than a calculus-free surface . | NA | {
"id": "C0011330",
"name": "dental calculus",
"pos": [
0,
15
]
} | {
"id": "C0006736",
"name": "calculus",
"pos": [
128,
136
]
} |
the 772 patients were randomized to receive either aspirin ( 325 mg once a day ) , aspirin ( 325 mg three times a day ) , aspirin plus dipyridamole ( 325 and 75 mg together three times a day ) ( aspirin group ) , sulfinpyrazone ( 267 mg three times a day ) or placebo ( nonaspirin group ) . | NA | {
"id": "C0732279",
"name": "aspirin",
"pos": [
51,
58
]
} | {
"id": "C0004057",
"name": "aspirin",
"pos": [
273,
280
]
} |
these results indicate that the extent of glycation of lysine residues in lens proteins is comparable to that of lysine residues in soluble proteins , such as hemoglobin and albumin , and that the extent of glycation of lens proteins does not increase with age . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
79,
87
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
174,
181
]
} |
induction of intracellular il-1 activity was associated with that of il-1 alpha and il-1 beta ag . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
27,
31
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
69,
79
]
} |
although anti-il-1 alpha , but not anti-il-1 beta , antibodies can efficiently block the il-1 bioactivity , both il-1 alpha and il-1 beta can be found by immunoprecipitation in the supernatants of the fixed monocytes . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
14,
18
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
113,
123
]
} |
washed platelets in buffered tyrode 's solution containing 2 mm magnesium were preincubated ( 30 min , 22 degrees c ) with antibodies , clq , or appropriate control buffers and antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
123,
133
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
177,
186
]
} |
human c-reactive protein ( crp ) is an acute phase reactant that is opsonic and an activator of macrophage tumoricidal function . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
6,
24
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
39,
59
]
} |
this antileishmanial activity was suppressed in a dose dependent fashion by ng-monomethyl-l-arginine ( ngmmla ) , a competitive inhibitor of nitrite , nitrate , nitric oxide and l-citrulline synthesis from l-arginine . | NA | {
"id": "C0069477",
"name": "ng-monomethyl-l-arginine",
"pos": [
76,
100
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
208,
216
]
} |
cross-antigenicity between the major surface proteins ( ospa and ospb ) and other proteins of borrelia burgdorferi . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
37,
53
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
82,
90
]
} |
in a second tumor ( s.c. ) that exhibited uniform anti-id tumor reactivity we were also able to demonstrate the presence of a second minor tumor cell population ( a biclonal tumor ) . | NA | {
"id": "C0085183",
"name": "second",
"pos": [
5,
11
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
174,
179
]
} |
cell separations showed the responder cells to be plastic and nylon wool nonadherent ia- t cells . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
50,
57
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
62,
67
]
} |
given that recent data suggest that the cd44 molecule may bind to specific ligands on endothelial cells ( vascular addressin ) and within the extracellular matrix ( collagen , fibronectin ) , these data raise the possibility that binding of t cells to endothelial cells or extracellular matrix proteins may induce or up-regulate t cell activation in inflammatory sites . | NA | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
176,
187
]
} | {
"id": "C0079323",
"name": "extracellular matrix proteins",
"pos": [
273,
302
]
} |
pbmc isolated from the peripheral circulation of hiv-infected donors , and cultured without added exogenous activators of il-6 production , produced markedly elevated amounts of il-6 when compared with cells isolated from healthy donors . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
0,
4
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
202,
207
]
} |
in contrast , another pi-anchored protein , alkaline phosphatase , was not altered by pma treatment , demonstrating that the pma effect is not uniform among all surface proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
34,
41
]
} | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
161,
177
]
} |
the increased expression of daf only was evident 8 h after pma addition and was blocked by the rna and protein synthesis inhibitors , actinomycin d and cycloheximide , indicating that both transcription and translation are required for daf synthesis induced by phorbol esters . | NA | {
"id": "C0039654",
"name": "pma",
"pos": [
59,
62
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
261,
275
]
} |
serum amyloid a ( saa ) is an acute phase reactant and the putative precursor of an amyloid fibril protein ( aa ) . | NA | {
"id": "C0002723",
"name": "serum amyloid a",
"pos": [
0,
15
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
30,
50
]
} |
we found a clear-cut increase in free cytoplasmic calcium when tonsil b cells or mononuclear cells from b cell chronic lymphatic leukemia patients were preincubated with cd24 mab and further stimulated with goat f ( ab ' ) 2 anti-mouse ig antibodies . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
175,
178
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
239,
249
]
} |
pge2-dependent inhibition by the three peptides was equivalent on a molar basis indicating that arg-pro-pro-gly contains the sequence responsible for this inhibitory effect of bk and is sufficient to exert pge-dependent inhibition of two-signal-dependent colony formation . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
0,
4
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
206,
209
]
} |
inhibition can be reversed by treating cells with fatty acid free bsa and , in agreement with our previous studies , indicates that the effects of ffa are due to physical perturbations of cellular components . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
50,
60
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
147,
150
]
} |
12-o-tetradecanoylphorbol-13-acetate ( tpa ) , a tumor-promoting phorbol ester , induced the proliferation of connective tissue-type mast cells ( ctmc ) synergistically with il-3 in a methylcellulose culture , as well as with il-4 . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
0,
36
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
65,
78
]
} |
in contrast , members of a family of mannose oligosaccharides ( disaccharide through hexasaccharide ) derived from the ctab mannan by weak alkaline degradation did not stimulate lymphoproliferation , but were potent inhibitors of lymphoproliferation stimulated by candida and other ag . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
45,
61
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
64,
76
]
} |
antibody directed to the o-specific polysaccharide ( ps ) side chain of pseudomonas aeruginosa lps provides immunotype-specific protection against infection by virtue of enhancing opsonophagocytosis . | NA | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
25,
50
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
95,
98
]
} |
immunoprecipitation of lsp1 protein from 32p-orthophosphate-loaded cells show that both the mouse and human lsp1 proteins are phosphoproteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
126,
141
]
} |
a simple interpretation of these data would suggest that certain positions of the peptide ag are most important for ag-mhc molecule interactions , and that these specific interactions can influence the antigenic epitope recognized by the tcr . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
202,
211
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
212,
219
]
} |
this antibody , mab l25 , also induced aggregation among human t and b tumor cell lines . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
16,
19
]
} |
the three aromatic amino acids , phenylalanine , tryptophan , and tyrosine , the charged hydrophilic amino acids , aspartic acid and lysine , and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested , whereas asparagine , cysteine , and histidine occurred the least often . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
10,
30
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
33,
46
]
} |
the three aromatic amino acids , phenylalanine , tryptophan , and tyrosine , the charged hydrophilic amino acids , aspartic acid and lysine , and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested , whereas asparagine , cysteine , and histidine occurred the least often . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
10,
30
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
49,
59
]
} |
the three aromatic amino acids , phenylalanine , tryptophan , and tyrosine , the charged hydrophilic amino acids , aspartic acid and lysine , and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested , whereas asparagine , cysteine , and histidine occurred the least often . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
10,
30
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
66,
74
]
} |
the three aromatic amino acids , phenylalanine , tryptophan , and tyrosine , the charged hydrophilic amino acids , aspartic acid and lysine , and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested , whereas asparagine , cysteine , and histidine occurred the least often . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
19,
30
]
} | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
150,
168
]
} |
the three aromatic amino acids , phenylalanine , tryptophan , and tyrosine , the charged hydrophilic amino acids , aspartic acid and lysine , and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested , whereas asparagine , cysteine , and histidine occurred the least often . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
19,
30
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
169,
176
]
} |
the three aromatic amino acids , phenylalanine , tryptophan , and tyrosine , the charged hydrophilic amino acids , aspartic acid and lysine , and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested , whereas asparagine , cysteine , and histidine occurred the least often . | NA | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
150,
168
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
280,
288
]
} |
inhibition of autoimmune disease in a murine model of systemic lupus erythematosus induced by exposure to syngeneic photoinactivated lymphocytes . | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
14,
32
]
} | {
"id": "C0024141",
"name": "systemic lupus",
"pos": [
54,
68
]
} |
levels of cytochrome p-450-mediated aryl hydrocarbon hydroxylase ( ahh ) are higher in differentiated than in germinative cutaneous keratinocytes . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
10,
26
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
36,
64
]
} |
induction of microsomal aryl hydrocarbon hydroxylase and cytochrome p-450 was observed in epidermal cells obtained from the skin of newborn rats exposed to benz ( a ) anthracene by topical exposure and in submerged cultures exposed to the procarcinogen in vitro . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
24,
52
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
57,
73
]
} |
the data suggest that sa11 rotavirus binds to a specific sialic acid structure on bsm different from the sialic acids recognized by other viruses . | NA | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
57,
68
]
} | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
105,
117
]
} |
one mab ( c4 ) was selected to develop a double antibody sandwich enzyme-linked immunosorbent assay ( elisa ) to detect s. typhi flagellin in serum samples . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
4,
7
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
48,
56
]
} |
six drugs have been examined : metronidazole , nitrofurazone , nifuroxime , chloramphenicol , m & b 4998 and 4 ( 5 ) -nitroimidazole , chosen to represent a variety of ring structures and a range of reduction potentials . | NA | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
31,
44
]
} | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
118,
132
]
} |
while these mice did not respond to the mono-epitope map bearing only the b or t epitope , very high titers of antibody and protective immunity against sporozoite challenge were elicited by di-epitope maps , particularly those with the b and t epitopes in tandem and present in equimolar amounts . | NA | {
"id": "C0003320",
"name": "maps",
"pos": [
201,
205
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
244,
252
]
} |
we developed a two-compartment model to simulate neuromuscular function and heart rate following the administration of four nondepolarizing neuromuscular blocking agents ( atracurium , vecuronium , pancuronium , and d-tubocurarine ) , three neuromuscular block reversal agents ( edrophonium , neostigmine , and pyridostigmine ) , and two anticholinergic agents ( atropine and glycopyrrolate ) . | NA | {
"id": "C2917437",
"name": "nondepolarizing neuromuscular",
"pos": [
124,
153
]
} | {
"id": "C0242531",
"name": "vecuronium",
"pos": [
185,
195
]
} |
we developed a two-compartment model to simulate neuromuscular function and heart rate following the administration of four nondepolarizing neuromuscular blocking agents ( atracurium , vecuronium , pancuronium , and d-tubocurarine ) , three neuromuscular block reversal agents ( edrophonium , neostigmine , and pyridostigmine ) , and two anticholinergic agents ( atropine and glycopyrrolate ) . | NA | {
"id": "C2917437",
"name": "nondepolarizing neuromuscular",
"pos": [
124,
153
]
} | {
"id": "C0030310",
"name": "pancuronium",
"pos": [
198,
209
]
} |
the latter patient , whose epileptic lesion was not completely excised because of its location in the motor cortex , had poor seizure control postoperatively . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
27,
36
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
126,
133
]
} |
pro-opiomelanocortin messenger ribonucleic acid ( mrna ) was found in the scca tissue to a greater degree than in the adenomas of the patients with cushing 's disease . | NA | {
"id": "C1306214",
"name": "scca",
"pos": [
74,
78
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
118,
126
]
} |
northern blot analysis revealed that the size of pro-opiomelanocortin mrna present in the scca tissue was indistinguishable from that in the adenomas associated with cushing 's disease . | NA | {
"id": "C1306214",
"name": "scca",
"pos": [
90,
94
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
141,
149
]
} |
because of the presence of pro-opiomelanocortin mrna and immunoreactive acth in the adenoma tissue , it is proposed that translation of the mrna and subsequent accumulation of acth precursor occurred in the scca . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
84,
91
]
} | {
"id": "C1306214",
"name": "scca",
"pos": [
207,
211
]
} |
while the approach should be validated for each antibody studied , freezing of therapeutic doses of monoclonal antibodies appears to be a simple and effective approach to the problem of autoradiolysis . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
48,
56
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
100,
121
]
} |
while the annual number of cases of listeriosis in patients without risk factors for hiv infection was constant , 9 of the 11 patients with aids or with risk factors for hiv infection presented with listeriosis between 1985 and 1988 , the last half of the survey period . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
140,
144
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
170,
183
]
} |
a hypothesis is presented in which hiv infection leads to immunodeficiency through indirect subversion of critical t cell regulatory mechanisms . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
35,
48
]
} | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
58,
74
]
} |
a series of aniline mustards with a wide range of electron-donating and -withdrawing substituents in the 3- and 4-positions has been synthesized and evaluated for cytotoxicity in cell culture to examine the potential of using nitro group deactivated nitrogen mustards for the design of novel hypoxia-selective anticancer drugs ( denny , w. a. ; wilson , w. r. j. med . chem . 1986 , 29 , 879 ) . | NA | {
"id": "C0003040",
"name": "aniline mustards",
"pos": [
12,
28
]
} | {
"id": "C0028165",
"name": "nitrogen mustards",
"pos": [
250,
267
]
} |
a series of 4 ( 3h ) -quinazolinones structurally related to 2-methyl-3-o-tolyl-4 ( 3h ) -quinazolinone ( methaqualone , 3 ) were synthesized and evaluated for anticonvulsant activity . | NA | {
"id": "C1720912",
"name": "quinazolinones",
"pos": [
22,
36
]
} | {
"id": "C0025627",
"name": "methaqualone",
"pos": [
106,
118
]
} |
fluoro carbocyclic nucleosides : synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1- ( 2-deoxy-2-fluoro-beta-d-arabinofuranosyl ) -5-methyluracil and carbocyclic 1- ( 2-deoxy-2-fluoro-beta-d-arabinofuranosyl ) -5-iodouracil . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
19,
30
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
99,
121
]
} |
reaction of hydroxyl-protected derivatives of hydroxyalkoxyamines ( 3a , b , c ) with either 4,6-dichloro-2,5-diformamidopyrimidine ( 5 ) or 4,6-dichloro-5-formamidopyrimidine ( 31 ) and subsequent cyclization of the resultant 6- ( alkoxyamino ) pyrimidines ( 6 , 17 , 32 , 35 ) by heating with diethoxymethyl acetate afforded 9-alkoxy-6-chloropurines ( 7 , 18 , 33 , 36 ) , which were converted subsequently to 9- ( 3-hydroxypropoxy ) - and 9- [ 3-hydroxy-2- ( hydroxymethyl ) propoxy ] derivatives of guanine , 2-amino-6-chloropurine , 2-amino-6-alkoxypurines , 2-aminopurine , 2,6-diaminopurine , adenine , hypoxanthine , and 6-methoxypurine ( 8 , 12 , 13 , 19-21 , 23-26 , 34 , 37-39 ) . | NA | {
"id": "C0000263",
"name": "2-aminopurine",
"pos": [
564,
577
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
600,
607
]
} |
the guanine derivatives ( 8 , 21 ) showed potent and selective activity against herpes simplex virus types 1 and 2 and varicella zoster virus in cell cultures and 8 is more active than acyclovir . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
4,
11
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
185,
194
]
} |
this substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
33,
48
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
157,
167
]
} |
unlike prototypical dihydropyridines such as nifedipine , these compounds did not seem to have any effect on calcium channels . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
20,
36
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
45,
55
]
} |
the conformationally restricted , cyclic disulfide-containing enkephalin analogue [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) was modified by halogenation ( f , cl , br , i ) of the phenylalanine-4 residue in the para position . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
62,
72
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
115,
120
]
} |
likewise , ac-pro-ala-pro-ala-co2me ( 21 ) was more potent than its corresponding trifluoromethyl ketone ( 9c ) in both porcine pancreatic elastase and human neutrophil elastase assays . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
128,
147
]
} | {
"id": "C0064833",
"name": "human neutrophil elastase",
"pos": [
152,
177
]
} |
therefore , the presented testing procedure consists of two parts : first , lateral and longitudinal resolution , image uniformity , sensitivity , and cyst and tumor imaging are determined by phantom tests ; | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
151,
155
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
160,
165
]
} |
a dna fragment from fowlpox virus cloned on a plasmid vector was modified to contain foreign dna inserts within an intergenic region . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
93,
96
]
} |
foreign dna inserts contained within the fowlpox virus sequence were transferred to the viral genome by homologous recombination occurring in cells infected with a fowlpox virus temperature-sensitive mutant and transfected with both wild-type viral dna and plasmid dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
8,
11
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
243,
252
]
} |
this plus-strand dna is initiated at a unique location and makes use of a purine-rich rna oligonucleotide derived by rnase h action on the viral rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
86,
89
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
139,
148
]
} |
there was a greater expression of fiv dna in lymphoid tissues , where the genome was normally detected , and in nonlymphoid tissues , where fiv dna was not usually found . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
144,
147
]
} |
the frequency of responder cells in individuals with specific response to peptides was 1:80,000 or fewer blood mononuclear cells , and the number of peptides responded to did not correlate with the proliferative response to vzv antigen . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "blood",
"pos": [
105,
110
]
} |
the viral 3c protease is the only fmdv protein required to induce the histone h3-pi transition , as well as being the only viral protein capable of cleaving histone h3 . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
39,
46
]
} | {
"id": "C0042736",
"name": "viral protein",
"pos": [
123,
136
]
} |
only the 16k band was obtained by cell-free translation , suggesting that the 16k protein is the precursor to the 11k protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
82,
89
]
} | {
"id": "C0033665",
"name": "precursor",
"pos": [
97,
106
]
} |
the 10.4k protein is a membrane protein , as shown by cell fractionation experiments and as predicted from its sequence . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
10,
17
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
23,
39
]
} |
detailed analyses of various integrants bearing rearranged viral dna failed to indicate any gross structural alteration in cellular dna , except for a small deletion at the integration site , indicating that viral dna rearrangement with inverted duplication possibly occurs before integration of hbv dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
65,
68
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
208,
217
]
} |
earlier studies of a group of monoclonal antibody-resistant ( mar ) mutants of herpes simplex virus type 1 glycoprotein c ( gc ) operationally defined two distinct antigenic sites on this molecule , each consisting of numerous overlapping epitopes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
164,
173
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
239,
247
]
} |
the predicted amino acid substitutions of site i mutants resided between residues gln-307 and pro-373 , whereas those of site ii mutants occurred between amino acids arg-129 and glu-247 . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
82,
85
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
178,
181
]
} |
moreover , the patterns of substitutions which affected recognition by antibodies with similar epitope specificities provided evidence that epitope structures are physically linked and overlap within antigenic sites . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
95,
102
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
200,
209
]
} |
substituted residues affecting the site i epitopes did not overlap substituted residues of site ii , supporting our earlier conclusion that sites i and ii reside in spatially distinct antigenic domains . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
42,
50
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
184,
193
]
} |
in human immunodeficiency virus ( hiv ) -infected individuals , the proportion of circulating mononuclear cells ( pbmcs ) which carry hiv provirus and the number of hiv proviral sequences per infected pbmc have been matters for conjecture . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
64,
67
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
201,
205
]
} |
as a general rule , only a small proportion of pbmcs contain provirus ( median value of samples from 12 patients , one per 8,000 cells ) , and most if not all of the infected cells carry a single provirus molecule . | NA | {
"id": "C1321301",
"name": "pbmcs",
"pos": [
47,
52
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
175,
180
]
} |
when considered in conjunction with estimates of the frequency of pbmcs that express viral rna , our results suggest that either ( i ) the majority of provirus-containing cells are monocytes or ( ii ) most provirus-containing lymphocytes are transcriptionally inactive . | NA | {
"id": "C1321301",
"name": "pbmcs",
"pos": [
66,
71
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
135,
138
]
} |
the methionine codon at bovine papillomavirus type 1 nucleotide 3091 was mutated to determine whether it may serve as an initiation codon for an e2 transcriptional repressor protein and to determine the role of the repressor in the biological activities of the virus . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
15,
20
]
} | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
121,
137
]
} |
a panel of murine monoclonal antibodies ( mabs ) to the human immunodeficiency virus type 1 trans-activator tat protein were characterized . | NA | {
"id": "C0040627",
"name": "trans-activator",
"pos": [
92,
107
]
} | {
"id": "C0039341",
"name": "tat protein",
"pos": [
108,
119
]
} |
saline or recombinant tissue plasminogen activator ( rt-pa , 1.3 mg/kg body weight ) was infused daily for 7 days starting from day 7 after the injection of antiglomerular basement membrane antiserum when the disease had been already triggered . | NA | {
"id": "C0032143",
"name": "recombinant tissue",
"pos": [
10,
28
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
56,
58
]
} |
following xrt , rats received only the amino acid glutamine ( 3 % , +gln ) in their drinking water or a control nonessential amino acid ( glycine , -gln ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
39,
49
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
138,
145
]
} |
at 12 hr , total ketone body concentrations of the arterial blood increased concomitant with a fall in ketone body ratio ( acetoacetate/3-hydroxybutyrate ) which reflects the decreased liver mitochondrial redox ( nad+/nadh ) state . | NA | {
"id": "C0022634",
"name": "ketone",
"pos": [
17,
23
]
} | {
"id": "C0022631",
"name": "ketone body",
"pos": [
103,
114
]
} |
over a 3-year period , 235 patients deposited 388 units of autologous blood : 6 for head and neck tumor surgery , 8 for neurosurgical tumors , 8 for gastrointestinal and colorectal tumor surgery , 14 for adrenal tumor surgery , 16 for gynecologic tumor surgery , 23 for soft tissue and bone tumor surgery , 25 for mastectomies and reconstructive breast surgery , 42 for genitourinary tumor surgery , and 93 for bone marrow aspirations for autologous transplants . | NA | {
"id": "C0017416",
"name": "gynecologic tumor",
"pos": [
235,
252
]
} | {
"id": "C0042065",
"name": "genitourinary tumor",
"pos": [
370,
389
]
} |
we found a good correlation in dna indices between fresh and paraffin-embedded specimens ( r = .978 ) , although one tumor with dna near-diploidy was mistaken as dna diploid in paraffin-embedded specimens . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
9,
10
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
162,
165
]
} |
we found a good correlation in dna indices between fresh and paraffin-embedded specimens ( r = .978 ) , although one tumor with dna near-diploidy was mistaken as dna diploid in paraffin-embedded specimens . | NA | {
"id": "C0012930",
"name": "tumor",
"pos": [
117,
122
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
162,
165
]
} |
basic amino acid ( lysine and ornithine ) polymers were employed as carriers for increasing the uptake of folate analogs by human leukemia cell lines . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
0,
16
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
19,
25
]
} |
basic amino acid ( lysine and ornithine ) polymers were employed as carriers for increasing the uptake of folate analogs by human leukemia cell lines . | NA | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
0,
16
]
} | {
"id": "C0029277",
"name": "ornithine",
"pos": [
30,
39
]
} |
extraintestinal and systemic manifestations occur commonly in patients with inflammatory bowel disease , specifically ulcerative colitis and crohn 's disease , and affect most all organ systems of the body . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
76,
102
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
141,
157
]
} |
before bone-marrow transplantation , there was strong recipient anti-donor cellular cytotoxic reactivity directed against several minor histocompatibility ( mh ) antigens , including the male-specific h-y antigen . | NA | {
"id": "C0026189",
"name": "minor histocompatibility",
"pos": [
130,
154
]
} | {
"id": "C0018449",
"name": "h-y antigen",
"pos": [
201,
212
]
} |
furthermore caffeine consumption was not associated with infertility in 1818 infertile women and their primiparous controls . | NA | {
"id": "C0021359",
"name": "infertility",
"pos": [
57,
68
]
} | {
"id": "C0021361",
"name": "infertile women",
"pos": [
77,
92
]
} |
those persons who arrived in australia between one and 20 years of age showed a lower proportion with solar keratoses in the younger age-groups , but with increasing age the proportion with solar keratoses equalled or exceeded that which was seen in australians . | NA | {
"id": "C0022602",
"name": "solar keratoses",
"pos": [
102,
117
]
} | {
"id": "C0022593",
"name": "keratoses",
"pos": [
196,
205
]
} |
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