text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
thus , one mechanism by which cis-unsaturated fatty acids lower ldl cholesterol may involve alteration in membrane lipid composition and physical properties , thereby leading to an increase in cellular clearance of this atherogenic lipoprotein . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
115,
120
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
232,
243
]
} |
in contrast , mouse peritoneal macrophages cleared esterified cholesterol efficiently to hdl , indicating that there are fundamental differences between mouse peritoneal macrophages and the other cells types studied in regard to cholesterol metabolism as influenced by hdl . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
62,
73
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
229,
240
]
} |
the hepatic lipase-deficient subjects had normal or elevated low density lipoprotein cholesterol and high density lipoprotein cholesterol concentrations . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
85,
96
]
} | {
"id": "C0023822",
"name": "high density lipoprotein cholesterol",
"pos": [
101,
137
]
} |
platelet deposition and fibrin formation were evaluated by morphometry , and fibrinopeptide a formation was assayed as a measure of thrombin generation . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
24,
30
]
} | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
77,
93
]
} |
the matrix of the stimulated endothelium also caused enhanced fibrinopeptide a generation , and platelet aggregates and fibrin were deposited on the matrix . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
62,
78
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
120,
126
]
} |
ps-smc and re-smc populations consisted of two distinct subpopulations , which could be discriminated by cell size measurements and cell adhesion : 1 ) relatively small ( cell diameter , 18.6 +/- 5 microns ) , low-adhesive , predominant cells , and 2 ) enlarged ( cell diameter , 27.1 +/- 3 microns ) , high-adhesive , fibroblast-like cells with abundant microfilaments . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
105,
109
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
319,
329
]
} |
nucleotide pools in dc3f cells , measured between drug treatment and death , show marked drops in pyrimidine levels while purine nucleotide levels decline more slowly . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
0,
10
]
} | {
"id": "C0034137",
"name": "purine nucleotide",
"pos": [
122,
139
]
} |
we have studied the effects of semi-synthetic diets rich in either n-9 ( olive oil , oo ) or n-6 ( corn oil , co ) , or n-3 ( fish oil , fo , as maxepa ) fatty acids on the levels of major pufa in platelet lipids , on the generation of inositol phosphates by [ 3h ] inositol labelled platelets after stimulation with thrombin and of thromboxane b2 ( txb2 ) by platelet rich plasma ( prp ) after stimulation with collagen . | NA | {
"id": "C0021554",
"name": "inositol",
"pos": [
236,
244
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
266,
274
]
} |
the length of the procedure , blood loss , degree of pharyngeal pain , otalgia , and incidence of postoperative hemorrhage was recorded for 106 consecutive patients . | NA | {
"id": "C0019080",
"name": "blood loss",
"pos": [
30,
40
]
} | {
"id": "C0032788",
"name": "postoperative hemorrhage",
"pos": [
98,
122
]
} |
a comparative analysis of the directives produced by mothers while interacting with young children with down syndrome and normally developing children was conducted . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
84,
98
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
142,
150
]
} |
the absorption and disposition of the potassium sparing diuretic amiloride were determined in nine elderly patients aged 71 to 87 years and in eight young ( 25 to 38 years ) subjects following oral administration of 5 mg amiloride hcl daily to steady-state . | NA | {
"id": "C0002502",
"name": "amiloride",
"pos": [
65,
74
]
} | {
"id": "C0546849",
"name": "amiloride hcl",
"pos": [
221,
234
]
} |
the excretion of diazepam , n-desmethyldiazepam , temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
30,
47
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
167,
175
]
} |
diazepam , n-desmethyldiazepam , temazepam and oxazepam were found in the maternal plasma and milk with mean milk : plasma ratios of 0.2 , 0.13 , 0.14 and 0.10 respectively . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
0,
8
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
13,
30
]
} |
diazepam could not be detected in the infant 's plasma , but low levels of n-desmethyldiazepam ( 20 and 21 micrograms l-1 ) , temazepam ( 7 micrograms l-1 ) and oxazepam ( 7.5 and 9.6 micrograms l-1 ) were present . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
0,
8
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
77,
94
]
} |
initial operative control of the bleeding superior mesenteric artery injury required ligation of the superior mesenteric artery at its origin to prevent exsanguination in an extremely unstable patient with multiple injuries . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
33,
41
]
} | {
"id": "C0232100",
"name": "exsanguination",
"pos": [
153,
167
]
} |
experiments were carried out in advanced l1210 leukaemia treated with combinations of adriamycin with cyclophosphamide , isophosphamide with acetylcysteine and methotrexate with leucovorin . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
102,
118
]
} | {
"id": "C0020823",
"name": "isophosphamide",
"pos": [
121,
135
]
} |
serum samples were taken from a total of 300 women who had either no breast disease , benign breast disease or breast cancer . | NA | {
"id": "C0006145",
"name": "breast disease",
"pos": [
69,
83
]
} | {
"id": "C0016034",
"name": "benign",
"pos": [
86,
92
]
} |
in dna digested samples of cddp sensitive ( glc4 ) and an 11-fold resistant ( glc4-cddp ) hsclc line , the cddp induced dna adducts pt-gg ( pt- ( nh3 ) 2d ( pgpg ] , pt-ag ( pt- ( nh3 ) 2d ( papg ] , g-pt-g ( pt- ( nh3 ) 2d ( gmp ) 2 ) and pt-gmp ( pt- ( nh3 ) 3d gmp ) , were measured with polyclonal antibodies . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
3,
6
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
120,
131
]
} |
the expression of the 72 kda glycoprotein was assessed on cryostat sections of a range of neoplastic and non-neoplastic tissues , using an avidin-biotin immunoperoxidase technique . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
29,
41
]
} | {
"id": "C0004434",
"name": "avidin",
"pos": [
139,
145
]
} |
the n-terminal amino-acid sequence analysis of subunits via and viii from sds-page gel bands of the three enzymes indicates the occurrence of three different isozymes in the rat . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
106,
113
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
158,
166
]
} |
l-alpha-glycerophospho-d-myo-inositol 4-phosphate ( gro-pip ) , but not glycerol 3-phosphate ( gro-3-p ) , l-alpha-glycerophospho-d-myo-inositol ( gro-pi ) , or l-alpha-glycerophospho-d-myo-inositol 4,5-bisphosphate ( gro-pip2 ) , inhibited pi-plc i in a concentration-dependent manner . | NA | {
"id": "C0021554",
"name": "myo-inositol",
"pos": [
25,
37
]
} | {
"id": "C0021547",
"name": "myo-inositol",
"pos": [
186,
198
]
} |
addition of 15 % margarine or butter alone or together with 2 % cholesterol resulted in a 2-3-fold increase in plasma ceta . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
64,
75
]
} | {
"id": "C0008387",
"name": "ceta",
"pos": [
118,
122
]
} |
hamsters consuming the cholesterol + butter-supplemented diets had the highest plasma ceta , cholesterol and triacylglycerol levels , while ceta in plasma of rats and mice remained nondetectable even after 4 weeks on the diet . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
23,
34
]
} | {
"id": "C0008387",
"name": "ceta",
"pos": [
140,
144
]
} |
radiolabeled apob-100 was also increased in media from hepg2 and caco-2 cells incubated with [ 35s ] methionine for 24 h in the presence of oleic acid , suggesting enhanced apob synthesis . | NA | {
"id": "C0205666",
"name": "apob-100",
"pos": [
13,
21
]
} | {
"id": "C0003593",
"name": "apob",
"pos": [
173,
177
]
} |
spermidine levels did not change over this time period , whereas spermine levels decreased by 35 % . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
11,
17
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
74,
80
]
} |
of several rat cell lines tested ( brl-3a , rat embryo fibroblasts ( ref ) , hepatoma cell lines ( h4 , htc ) , gh3 pituitary tumor cells , and normal rat kidney fibroblasts ( nrk ] , only brl-3a and ref cells secreted measurable e-domain peptide into the medium . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} | {
"id": "C0016030",
"name": "ref",
"pos": [
200,
203
]
} |
in order to study whether their carbohydrate moieties play a role in ligand binding , membrane preparations ( adjusted to 0.2 mg protein me ) were incubated with 20 pm 125-i-cck octapeptide ( 125i-cck8 ) for 4 h at 30 degrees c in the presence of lectins with different sugar specificities . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
129,
136
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
247,
254
]
} |
rheumatoid synovial fibroblasts were treated with purified porcine interleukin 1 alpha and recombinant human interleukin 1b , and the production of secreted and cell-associated plasminogen activator activity was measured . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
161,
165
]
} |
while hydrated dipalmitoyl phosphatidylcholine ( dppc ) forms tilted chain l beta ' bilayers in the gel phase , the ether-linked analogue dihexadecyl phosphatidylcholine ( dhpc ) exhibits gel phase polymorphism . | NA | {
"id": "C0000039",
"name": "dipalmitoyl phosphatidylcholine",
"pos": [
15,
46
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
150,
169
]
} |
highly enriched populations of hematopoietic progenitor cells were obtained by isolating lineage negative ( lin- ) , thy-1-positive ( thy-1+ ) fresh bone marrow cells , or by isolating cells from interleukin-3 ( il-3 ) supplemented bone marrow cultures expressing thy-1 antigen with the fluorescent activated cell sorter . | NA | {
"id": "C0018956",
"name": "hematopoietic progenitor cells",
"pos": [
31,
61
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
185,
190
]
} |
thus , the current studies establish a remarkable similarity between the hematopoietic microenvironment in the short-term cfu-f assay and the long-term culture system : the majority of adherent cells are hematopoietic cells of the monocyte-macrophage lineage , while the remainder are stromal cells whose precise lineage remains uncertain , but whose pattern of collagen expression is more consistent with an endothelial rather than a fibroblast cell origin . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
7,
10
]
} | {
"id": "C0016030",
"name": "fibroblast cell",
"pos": [
435,
450
]
} |
a unique b-cell non-hodgkin 's lymphoma ( nhl ) cell line ( karpas 422 ) , bearing both t ( 14 ; 18 ) and t ( 4 ; 11 ) chromosomal translocations as well as several other chromosomal abnormalities , has been established from the pleural effusion of a patient with chemotherapy-resistant nhl . | NA | {
"id": "C0079731",
"name": "b-cell non-hodgkin 's lymphoma",
"pos": [
9,
39
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
287,
290
]
} |
these proteins share a common feature that glycan-inositolphospholipid anchors the protein to the membrane , suggesting that an abnormality related to this glycolipid causes multiple protein deficiencies . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0025252",
"name": "protein",
"pos": [
183,
190
]
} |
viral and bacterial infections are a serious cause of morbidity and mortality in patients immunocompromised as a result of malignancy , burns , trauma , viral infections or chemotherapy . | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
136,
141
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
144,
150
]
} |
single dose cefotaxime plus metronidazole versus three dose cefuroxime plus metronidazole as prophylaxis against wound infection in colorectal surgery : multicentre prospective randomised study . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
12,
22
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
60,
70
]
} |
aml-cfu were shown to be less sensitive than human promyelocytic leukemia cells ( hl-60 ) to the toxic effects of these two drugs . | NA | {
"id": "C0023467",
"name": "aml",
"pos": [
0,
3
]
} | {
"id": "C0023487",
"name": "promyelocytic leukemia",
"pos": [
51,
73
]
} |
however , if the intermediary antibodies were of the igg2 isotype , the efficiency of target cell depletion with these beads was inferior . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
30,
40
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
58,
65
]
} |
these findings indicate that the efficiency of immunomagnetic bone marrow purging is dependent upon matching of the targeting moab and the secondary antibodies that link to the surface to the microbeads . | NA | {
"id": "C0003250",
"name": "moab",
"pos": [
126,
130
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
149,
159
]
} |
human primary germ cell tumors were analyzed for the presence of the ganglioside gm2 using three specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety : the antibody mk1-16 is specific for n-acetyl gm2 , mk2-34 is specific for n-glycolyl gm2 , and mk1-17 detects both n-acetyl and n-glycolyl gm2 . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
106,
127
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
204,
212
]
} |
six cases represented second malignancies that arose 5 to 16 years after irradiation for an unrelated tumor . | NA | {
"id": "C0085183",
"name": "second",
"pos": [
22,
28
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
102,
107
]
} |
in the case of beta-lactams , information on structure-activity relationships gleaned from penicillins and cephalosporins was rapidly applied to the cephamycins , monobactams , penems , and carbapenems in order to discover broad-spectrum agents with markedly improved potency . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
15,
27
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
91,
102
]
} |
in the case of beta-lactams , information on structure-activity relationships gleaned from penicillins and cephalosporins was rapidly applied to the cephamycins , monobactams , penems , and carbapenems in order to discover broad-spectrum agents with markedly improved potency . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
15,
27
]
} | {
"id": "C0026458",
"name": "monobactams",
"pos": [
163,
174
]
} |
in the case of beta-lactams , information on structure-activity relationships gleaned from penicillins and cephalosporins was rapidly applied to the cephamycins , monobactams , penems , and carbapenems in order to discover broad-spectrum agents with markedly improved potency . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
15,
27
]
} | {
"id": "C0006968",
"name": "carbapenems",
"pos": [
190,
201
]
} |
in the case of beta-lactams , information on structure-activity relationships gleaned from penicillins and cephalosporins was rapidly applied to the cephamycins , monobactams , penems , and carbapenems in order to discover broad-spectrum agents with markedly improved potency . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
107,
121
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
149,
160
]
} |
biotransformation of n , n ' , n '' -triethylenethiophosphoramide : oxidative desulfuration to yield n , n ' , n '' -triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic p-450 monooxygenase . | NA | {
"id": "C0039871",
"name": "triethylenethiophosphoramide",
"pos": [
37,
65
]
} | {
"id": "C0039533",
"name": "triethylenephosphoramide",
"pos": [
117,
141
]
} |
oxidative metabolism of the polyfunctional alkylating agent n , n ' , n '' -triethylenethiophosphoramide ( thio-tepa ) was studied in isolated rat liver microsomes and purified , reconstituted cytochrome p-450 ( p-450 ) enzyme systems in order to elucidate the pathways of drug oxidation and to identify the possible contributions of individual p-450 enzymes to the bioactivation of this chemotherapeutic agent . | NA | {
"id": "C0039871",
"name": "triethylenethiophosphoramide",
"pos": [
76,
104
]
} | {
"id": "C0039533",
"name": "tepa",
"pos": [
112,
116
]
} |
the relative risk of death was twofold higher in single dna-aneuploid and threefold higher in dna-multiploid tumors than in dna-diploid tumors . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
56,
59
]
} | {
"id": "C0012930",
"name": "dna",
"pos": [
124,
127
]
} |
among the three isozymes , type ii enzyme was most sensitive to tpa with histone h1 as the substrate , although all three isozymes were activated ca2+-dependently in the presence of phosphatidylserine . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
35,
41
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
122,
130
]
} |
studies conducted with types i , ii , and iii rat brain isozymes , resolved by hydroxylapatite chromatography , demonstrate that dequalinium inhibits each of them with similar potency ( 50 % inhibitory concentration of 11 microm ) and imply that the site of contact on the enzyme is a highly conserved region . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
56,
64
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
273,
279
]
} |
increasing camp levels ( up to 24-fold ) with n6 , o2'-dibutyryl cyclic amp ( dbcamp ) or 8-bromo-camp also resulted in decreased proliferation and an increase in morphological differentiation . | NA | {
"id": "C0001455",
"name": "camp",
"pos": [
11,
15
]
} | {
"id": "C0000661",
"name": "8-bromo-camp",
"pos": [
90,
102
]
} |
of the agents that raised camp levels , only dbcamp caused an increase in acetylcholinesterase activity . | NA | {
"id": "C0001455",
"name": "camp",
"pos": [
26,
30
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
45,
51
]
} |
the efficacy in cancer treatment of monoclonal antibodies or other macromolecules bound to radionuclides , chemotherapeutic agents , toxins , enzymes , growth factors , or effector antibodies has been limited by their inability to reach their target in vivo in adequate quantities . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
36,
57
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
181,
191
]
} |
all of these mabs , except mu-9 , identify epitopes that can be detected in plasma , but none of the mabs complexed appreciably when mixed in vitro with plasma containing antigen at antigen/mab ratios anticipated to be encountered most frequently in imaging or therapy applications in humans . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
43,
51
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
182,
189
]
} |
ht-29-15 , a murine monoclonal antibody ( mab ) of the igg1 class reactive with the ht-29 lmm line , and bl-3 , an isotype-matched control antibody , were labeled with 125i . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
115,
122
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
139,
147
]
} |
in the last decade of radioimmunodetection studies the radiolabeled antibody preparations used have gradually changed from polyclonal antibodies labeled predominantly with 131i to monoclonal antibodies labeled with diverse radionuclides including 131i , 111in , 123i , and 99mtc . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
68,
76
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
180,
201
]
} |
rapid targeting and clearance from blood and normal organs of the antibody fragments ( blood median t1/2 elimination of 26.5 and 13.2 h for the f ( ab ' ) 2 and fab ' fragments respectively ) permitted the use of short-lived radionuclides , such as 123i ( 13.3 h ) and 99mtc ( 6 h ) , and confirmed that selective antibody accretion in tumors occurred very soon after administration , such as between 2 and 5 h . | NA | {
"id": "C0021009",
"name": "antibody fragments",
"pos": [
66,
84
]
} | {
"id": "C0021031",
"name": "fab",
"pos": [
161,
164
]
} |
by allowing intact igg to be used instead of fragments , a higher percentage of the radiolabeled anti-tumor antibodies may be concentrated in the tumor to provide higher tumor doses , yet toxicity to the normal tissues may be controlled by the removal of the radiolabeled antibody from the blood . | NA | {
"id": "C0003251",
"name": "tumor antibodies",
"pos": [
102,
118
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
272,
280
]
} |
in this study we show that sc-1 mabs are directed against a restricted number of epitopes , and that sc-1 mabs and a polyclonal antiserum directed against the neural cell adhesion molecule ( ncam ) recognize identical glycoproteins , indicating that sc-1 antigens are closely related to or identical with ncam . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
81,
89
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
255,
263
]
} |
we reported previously using a murine model that the kidney is the organ involved in catabolism of exogenous human recombinant interleukin 2 ( il-2 ) and that cathepsin d , a major renal acid protease , is responsible for the degradation of il-2 . | NA | {
"id": "C0218986",
"name": "human recombinant interleukin 2",
"pos": [
109,
140
]
} | {
"id": "C0021756",
"name": "il-2",
"pos": [
241,
245
]
} |
the treatment of hl-60 promyelocytic leukemia cells with phorbol esters ( 12-o-tetradecanoylphorbol-13-acetate ) results in the appearance of cell substrate adhesion and the release of a mr 94,000 gelatin-degrading metalloprotease . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
57,
71
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
74,
110
]
} |
thus , the mr 94,000 metalloprotease from hl-60 cells appears to be a distinct and new member of the collagenase family of proteases . | NA | {
"id": "C0025543",
"name": "metalloprotease",
"pos": [
21,
36
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
123,
132
]
} |
lu-49888 labeling of pgp was also inhibited by actinomycin d ( 45 % ) , podophyllotoxin ( 47 % ) , and amsacrine ( 82 % ) , marginally by doxorubicin ( 25 % ) , colchicine ( 22 % ) , daunorubicin ( 18 % ) , and etoposide ( 14 % ) , but not by teniposide . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
138,
149
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
183,
195
]
} |
the results indicate that denitrosation is a major metabolic pathway for ndma elimination and suggest that deuteration of the carcinogen induces a shift in its metabolism toward increasing denitrosation at the expense of the competing activation pathway . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
78,
89
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
160,
170
]
} |
the il-2-activated cells have usually been generated by obtaining peripheral blood mononuclear cells ( pbmc ) from cancer patients shortly after systemic il-2 therapy and culturing them with il-2 in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
19,
24
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
66,
100
]
} |
in an effort to augment the ex vivo generation of such cells preactivated in vivo , we examined the proliferative responses of pbmc from il-2-treated cancer patients to several proliferative signals including il-2 , interleukin 4 ( il-4 ) , and mitogenic antibodies to cd3 and cd28 . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
24,
27
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
127,
131
]
} |
on a molar basis the phorbol ester ( 12-o-tetradecanoylphorbol-13-acetate ) was the most effective inducer of monocyte differentiation , followed by 1,25-dihydroxy-16-ene-23-ynecholecalciferol which was more effective than 1,25-dihydroxycholecalciferol . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
21,
34
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
37,
73
]
} |
cultured melanoma cells are known targets for the pigment-inducing actions of melanotropins such as alpha-melanocyte-stimulating hormone ( alpha-msh ) . | NA | {
"id": "C0026667",
"name": "melanotropins",
"pos": [
78,
91
]
} | {
"id": "C0002302",
"name": "alpha-melanocyte-stimulating hormone",
"pos": [
100,
136
]
} |
furthermore , the respective potencies of three melanotropins , ndp-msh , alpha-msh , and adrenocorticotropic hormone , in binding and biological assays were highly correlated . | NA | {
"id": "C0026667",
"name": "melanotropins",
"pos": [
48,
61
]
} | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
74,
83
]
} |
point mutations of c-k-ras in codon 12 were detected by rna-dna rnase a mismatch cleavage after in vitro dna amplification of the cellular c-k-ras sequences by the polymerase chain reaction . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
60,
63
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
183,
184
]
} |
neuronal pathways in the retrocerebral complex and thoracico-abdominal ganglionic mass of the blowfly calliphora vomitoria have been identified immunocytochemically with antisera against the extended-enkephalins , met-enkephalin-arg6-phe7 ( met-7 ) and met-enkephalin-arg6-gly7-leu8 ( met-8 ) . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
200,
211
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
253,
267
]
} |
the atpase activity of seca is stimulated by e. coli plasma membrane vesicles bearing secy protein and a precursor protein such as proompa . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
91,
98
]
} | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
105,
122
]
} |
reaction intermediates contain holliday junctions that are driven along the dna at a maximal rate approaching 1000 bases per minute . | NA | {
"id": "C1258072",
"name": "holliday junctions",
"pos": [
31,
49
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
76,
79
]
} |
tac expression was induced by active phorbol esters ( 12-o-tetradecanoylphorbol 13-acetate [ tpa ] and 4 beta-phorbol 12,13-didecanoate ) , which directly activate protein kinase c ( pkc ) , as well as forskolin ( fk ) , a stimulator of adenylate cyclase . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
37,
51
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
54,
90
]
} |
in contrast , ctl responses against allogeneic determinants could not be completely blocked with antibodies against l3t4 and depletion of l3t4+ cells did not prevent the generation of alloreactive ctls in cultures stimulated with allogeneic spleen cells or activated t cell lymphoblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
144,
149
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
230,
240
]
} |
our earlier studies have demonstrated that intragastric administration of the hapten trinitrochlorobenzene ( tncb ) 2 to 3 weeks prior to attempting sensitization with epidermally applied hapten can abrogate development of systemic contact sensitivity ( cs ) . | NA | {
"id": "C0031891",
"name": "trinitrochlorobenzene",
"pos": [
85,
106
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
188,
194
]
} |
although cs decreased by 10-12 days after feeding tncb , the decline was reversed by pretreating mice with cyclophosphamide ( cy ) 2 days before giving the hapten . | NA | {
"id": "C0031891",
"name": "tncb",
"pos": [
50,
54
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
156,
162
]
} |
putrescine and spermidine levels were decreased and spermine levels were increased in spleen and lymph node cells from drug-treated mice compared to control arthritic mice . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
0,
10
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
61,
67
]
} |
putrescine and spermidine levels were decreased and spermine levels were increased in spleen and lymph node cells from drug-treated mice compared to control arthritic mice . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
26,
32
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
61,
67
]
} |
recognition of the symptoms characteristic of these fractures ( vague thigh pain , diffuse tenderness , no trauma ) will assist early diagnosis . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
52,
61
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} |
finally , the relative level of expression of the ca2 ( + ) -atpase gene was studied by dot blot analysis at both the mrna and protein levels using complementary dna clones and a monoclonal antibody specific to the sarcoplasmic reticulum ca2 ( + ) -atpase . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
50,
53
]
} | {
"id": "C0916181",
"name": "sarcoplasmic reticulum ca2",
"pos": [
215,
241
]
} |
the time course of the effects of phenylephrine ( 10 mumol/l ) on force of contraction and on inositol phosphates in electrically driven left auricles from rat hearts labeled with [ 3h ] inositol was studied . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
94,
113
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
187,
195
]
} |
the participation of presynaptic and postsynaptic alpha-adrenoceptors , as well as of alpha 1- and alpha 2-adrenoceptors , in experimental and clinical myocardial ischemia will require further investigation . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
50,
69
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptors",
"pos": [
99,
120
]
} |
these results were compared with those found in 11 control patients matched for age , sex , and heart disease to determine whether the response of the qt interval to exercise testing was abnormal in patients who developed worsening of arrhythmia while taking antiarrhythmic drugs . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
96,
109
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
235,
245
]
} |
with respect to angina pectoris , the complement system is mildly activated in patients with unstable angina pectoris ; | NA | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
16,
31
]
} | {
"id": "C0002965",
"name": "unstable angina pectoris",
"pos": [
93,
117
]
} |
to investigate whether physiologic catecholamine secretion is exocytotic in humans , we measured plasma norepinephrine , epinephrine , and cga responses to differentiated stimuli of sympathoadrenal discharge . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
104,
118
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
121,
132
]
} |
reperfusion in patients after a short period of ischemia ( less than 30 minutes ; group 1 ) resulted in a small and transient release in the coronary sinus of gssg and gsh and in a progressive improvement of hemodynamic parameters reaching a stable state 4 hours after the operation . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
159,
163
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
168,
171
]
} |
in patients with a period of ischemia longer than 30 minutes ( group 2 ) , reperfusion induced a marked and sustained release of lactate , gsh , and gssg ; | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
139,
142
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
149,
153
]
} |
scan patterns were correlated with clinical evidence for residual ischemia occurring within 6 weeks of infarct and including infarct extension , recurrent angina , and positive predischarge low-level or 6-week symptom-limited stress tests and with coronary anatomy . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
66,
74
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
125,
132
]
} |
effects of h1-receptor stimulation on coronary arterial diameter and coronary hemodynamics were examined in 11 patients with angiographically normal coronary arteries and without variant angina or resting angina . | NA | {
"id": "C0002963",
"name": "variant angina",
"pos": [
179,
193
]
} | {
"id": "C0002965",
"name": "resting angina",
"pos": [
197,
211
]
} |
three classifications of chest pain were defined using the rose questionnaire : nonexertional chest pain , chest pain on exertion ( including angina ) , and angina . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
25,
35
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
157,
163
]
} |
technetium 99m-hexakis-2-methoxy-2-methylpropyl-isonitrile ( tc-mibi ) is a promising new myocardial perfusion imaging agent producing excellent rest images . | NA | {
"id": "C0303611",
"name": "technetium 99m",
"pos": [
0,
14
]
} | {
"id": "C0162680",
"name": "tc-mibi",
"pos": [
61,
68
]
} |
we found that freshly collected , never-frozen human sera must be used to assess interlaboratory accuracy for cholesterol , hdl cholesterol , and triglycerides assays , and that at least 23 samples are required to detect a 3 % bias with 90 % power when the between-laboratory imprecision ( cv ) is 3 % . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
110,
121
]
} | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
124,
139
]
} |
pools of frozen human sera were shown to have matrix biases greater than 3 % for cholesterol in seven of 11 laboratories , and greater than 40 mg/l for hdl cholesterol in six of nine laboratories . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
81,
92
]
} | {
"id": "C0023822",
"name": "hdl",
"pos": [
152,
155
]
} |
monoclonal antibody ckm-g01 inhibited greater than 99 % of the activity of porcine and human creatine kinase ( ck ) -mm isoenzyme purified from muscle . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
93,
108
]
} | {
"id": "C0010291",
"name": "ck",
"pos": [
111,
113
]
} |
apolipoprotein e polymorphism did not affect lp ( a ) concentrations , but had a major influence on apolipoprotein b concentration . | NA | {
"id": "C0003595",
"name": "apolipoprotein e",
"pos": [
0,
16
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
100,
114
]
} |
when tg were less than or equal to 4.00 g/l , 86 % of estimated ldl cholesterol values were properly classified according to national cholesterol education program cutpoints when the factor tg/5 was used . | NA | {
"id": "C0023824",
"name": "ldl",
"pos": [
64,
67
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
134,
145
]
} |
neither the polyester polymer in sst tubes nor a hemolysate had any detectable effect on psa values . | NA | {
"id": "C0032474",
"name": "polyester",
"pos": [
12,
21
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
22,
29
]
} |
fibrils from heart tissue of a patient with primary amyloidosis , now examined for the first time , contained four major gags ( chondroitin sulfate , dermatan sulfate , hyaluronic acid , and heparan sulfate ) . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
121,
125
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
191,
206
]
} |
using these data , we determined the relationship between the area of chloride precipitation and the chloride concentration of the standard nacl solutions . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
70,
78
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
140,
144
]
} |
splenic vein thrombosis following pancreatitis should be considered in all patients with pancreatic disease as this complication is increasingly recognised as a cause of upper gastrointestinal haemorrhage from varices . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
34,
46
]
} | {
"id": "C0030286",
"name": "pancreatic disease",
"pos": [
89,
107
]
} |
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