text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
[ ca2+ ] i was also measured in the platelets of a group of 12 primigravid pregnant women in the third trimester whose pregnancies were complicated by gestational hypertension ( pregnancy-induced hypertension and pre-eclampsia ) . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
97,
112
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
119,
130
]
} |
a significant rise in basal [ ca2+ ] i was noted in the platelets of primigravidae whose pregnancies were complicated by pre-eclampsia ( 163.6 +/- 8.8 nmol/l ) as compared with normotensive , third-trimester primigravidae ( p less than 0.02 ) . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
89,
100
]
} | {
"id": "C0032981",
"name": "third-trimester",
"pos": [
192,
207
]
} |
density and affinity ( determined as the apparent dissociation constant ) of platelet alpha 2-adrenergic receptors , and plasma adrenaline and noradrenaline levels , were measured after overnight bed-rest and after 9 min of standardized exercise performed before and after the low caloric diet . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
128,
138
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
143,
156
]
} |
the proportions of patients with a record of body weight , blood pressure , urinary glucose , urinary protein , blood glucose , hba1 , visual acuity , examination of the fundus through dilated pupils , examination of the feet , and a consultation with a dietitian within the previous year increased significantly and were higher in mini-clinic than in comparison practices although , for a substantial number of patients in both groups of practices , these remained unrecorded . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
84,
91
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
112,
125
]
} |
although routine patient education concerning periodontal disease is recommended as a means of improving oral health , strong associations between oral health knowledge and plaque or gingival inflammation scores have not been demonstrated . | NA | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
46,
65
]
} | {
"id": "C0017574",
"name": "gingival inflammation",
"pos": [
183,
204
]
} |
in the present experiments , severely bled ( 45 ml/kg ) dogs were treated with one of three nacl/dextran-70 solutions : s1 , 25 % nacl + 24 % dextran ( 1.5 ml/kg ) ; | NA | {
"id": "C0011795",
"name": "dextran-70",
"pos": [
97,
107
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
142,
149
]
} |
the practical use of these drugs in rheumatoid arthritis , systemic lupus erythematosus , and vasculitis ( including wegener 's granulomatosis and sjogren 's syndrome ) are reviewed . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
36,
56
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
147,
166
]
} |
infection with the human immunodeficiency virus ( hiv ) results in a progressive immune deficiency involving many components of the immune system . | NA | {
"id": "C0019693",
"name": "infection",
"pos": [
0,
9
]
} | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
81,
98
]
} |
lipids comprise 15 % of nonprotein calories with 50 % fish oil ( high in omega-3 fatty acids ) and 50 % safflower oil ( high in linoleic acid ) . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
54,
62
]
} | {
"id": "C0015689",
"name": "omega-3 fatty",
"pos": [
73,
86
]
} |
sixty-nine instances of intracerebral complications of diabetic ketoacidosis ( dka ) , including 29 unpublished occurrences , were analyzed to determine predictive factors , the frequency of other disorders resembling cerebral edema , the effectiveness of intervention to reduce intracranial pressure , and whether any etiologic considerations appeared valid . | NA | {
"id": "C0342257",
"name": "complications",
"pos": [
38,
51
]
} | {
"id": "C0011880",
"name": "dka",
"pos": [
79,
82
]
} |
in contrast are patients from families who have very high insulin responses to glucose , despite glucose intolerance and fasting hyperglycemia similar to that seen in patients with low insulin responses . | NA | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
97,
116
]
} | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
129,
142
]
} |
kt1 was found to be of the immunoglobulin m isotype and reacted specifically with islet cells . | NA | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
27,
43
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
44,
51
]
} |
ultrasonography and intravenous pyelography ( ivp ) were compared for their diagnostic value in 65 patients ( 29 women , 36 men ; mean age 57 [ 19-85 ] years ) thought to have disease of the kidneys or urinary tract ( microhaematuria in 16 , macrohaematuria in 5 , urinary tract infection in 11 , suspicion of renovascular hypertension in 6 , suspected tumour in 5 , suspected nephrolithiasis in 15 , and flank pain of uncertain cause in 7 ) . | NA | {
"id": "C0022658",
"name": "disease of",
"pos": [
176,
186
]
} | {
"id": "C0392525",
"name": "nephrolithiasis",
"pos": [
377,
392
]
} |
the characteristics of mabs igr-1 and igr-2 permit concluding that the antibodies should be useful in normal and leukemic myelomonocytic cell linear differentiation studies . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
23,
27
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
71,
81
]
} |
( a ) a stimulation paradigm consisting of series of trains of flicker stimuli randomly presented to the epileptic patient , after eye closure , to get epileptic responses while avoiding seizures ; | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
105,
114
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
187,
195
]
} |
eighty-five percent of the l-tgf beta bound to lentil lectin , and this separated into four discrete l-tgf beta peaks ( i-iv ) at 0.22 , 0.25 , 0.35 , and 0.42 m nacl with mono-q anion exchange chromatography . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
1,
2
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
179,
184
]
} |
there were three discrete peaks of tgf beta activity corresponding to tgf beta 1 , tgf beta 2 , and an unidentified form of tgf . | NA | {
"id": "C0040690",
"name": "tgf beta",
"pos": [
35,
43
]
} | {
"id": "C0079441",
"name": "tgf beta 2",
"pos": [
83,
93
]
} |
the distinct but markedly diminished insulin and proinsulin peaks in hd dogs nearly disappeared in nd dogs . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
37,
44
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
49,
59
]
} |
normoglycemia 1 ) normalizes somatostatin content , 2 ) further diminishes insulin and proinsulin synthesis presumably due to lack of hyperglycemic stimulus , and 3 ) paradoxically decreases pancreatic glucagon content 5-fold below its normal level . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
75,
82
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
87,
97
]
} |
dihydrotestosterone was formed in negligible amounts in these cells , and in some experiments the residual 5 alpha-reductase activity was further blocked with the 5 alpha-reductase inhibitor finasteride . | NA | {
"id": "C1318898",
"name": "5 alpha-reductase inhibitor",
"pos": [
163,
190
]
} | {
"id": "C0060389",
"name": "finasteride",
"pos": [
191,
202
]
} |
to determine whether galanin ( gal ) , a 29-amino acid neuropeptide , plays a role in the physiological regulation of the pulsatile secretion of gh and prl in the male rat , secretory patterns of both hormones were studied in freely moving animals after gal passive immunoneutralization . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
55,
67
]
} | {
"id": "C0060993",
"name": "gal",
"pos": [
254,
257
]
} |
to examine the effect of interleukin-1 ( il-1 ) on crf and pomc gene expression , recombinant human il-1 alpha and -beta were ip injected in rats . | NA | {
"id": "C0021755",
"name": "interleukin-1",
"pos": [
25,
38
]
} | {
"id": "C0600251",
"name": "recombinant",
"pos": [
82,
93
]
} |
to elucidate differential roles of protein kinase c isozymes in pancreatic islet cells , the precise localization of the isozymes in rabbit and rat islet endocrine cells was investigated using monoclonal antibodies specific for three types of the enzyme . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
52,
60
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
247,
253
]
} |
in an attempt to further study various fragments of free and combined forms of hcg beta present in biological fluids , we performed one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis , followed by western immunoblotting using antipeptide antibodies directed to the hcg beta- ( 111-116 ) portion ( monoclonal antibody fb12 ) antiserum to the hcg beta ( 8-16 ) portion or antiserum which was specific for fragments ending at residue 47 . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
270,
280
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
329,
348
]
} |
in an attempt to further study various fragments of free and combined forms of hcg beta present in biological fluids , we performed one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis , followed by western immunoblotting using antipeptide antibodies directed to the hcg beta- ( 111-116 ) portion ( monoclonal antibody fb12 ) antiserum to the hcg beta ( 8-16 ) portion or antiserum which was specific for fragments ending at residue 47 . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
270,
280
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
402,
411
]
} |
subcutaneous administration of dom resulted in elevated prl levels which could be further augmented by iv infusion of ot ( at 0.01 or 0.1 microgram ot/kg.min ) or partially , but significantly , reduced by pretreatment with anti-ot antiserum ( 0.75 ml ) indicating that under conditions of da blockade , ot ( which has little prf activity during conditions of normal dopaminergic tone ) can stimulate prl secretion by a direct pituitary action . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
290,
292
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
367,
379
]
} |
the af was not specific for thyroid cells , however , since conditioned medium from tsh treated frtl-5 cells was also found to potentiate the mitogenic effect of igf-i in the human fibroblast cell line gm3652 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
36,
41
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
181,
191
]
} |
it is unlikely that the af activity secreted by these cells in response to tsh is either igf or an igf-binding protein , since the anti-igf monoclonal antibody sm 1.2 did not attenuate the synergism between tsh and high concentrations of insulin on thymidine incorporation . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
89,
92
]
} | {
"id": "C0021666",
"name": "igf",
"pos": [
136,
139
]
} |
tgf beta inhibited basic fibroblast growth factor ( bfgf ) stimulation of t1 and t5 cell thymidine incorporation . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
25,
35
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
84,
88
]
} |
perifusing 0.2 mm nimodipine , a dihydropyridine ca2+ channel blocker , before and after restoration of ca2+ to the ca2 ( + ) -free medium inhibited acth release by 40-48 % , and the blockade persisted for at least 70 min after nimodipine was removed from the medium . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
33,
48
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
228,
238
]
} |
blockade of l-type voltage-sensitive ca2+ channels with nimodipine , a dihydropyridine drug , had the same effect as ca2+e removal on both the initial spike and sustained plateau phases of the response to avp . | NA | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
56,
66
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
71,
86
]
} |
enhancement of thyroxine entry into low density lipoprotein ( ldl ) receptor-competent fibroblasts by ldl : an additional mode of entry of thyroxine into cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
87,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
the specificity of the ldl effect was shown by the finding that t4-binding globulin , prealbumin , or serum albumin , at concentrations giving 10-90 % t4 bound , failed to increase t4 uptake . | NA | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
86,
96
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
102,
107
]
} |
thrombin produced a dose-dependent increase in the accumulation of [ 3h ] inositol phosphates ( ips ) in umr 106-h5 cells prelabeled with [ 3h ] myo-inositol ( ec50 15 u/ml ) . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
74,
93
]
} | {
"id": "C0021547",
"name": "myo-inositol",
"pos": [
145,
157
]
} |
whereas in fibroblasts and platelets , thrombin receptors appear to couple to both pt-sensitive and pt-insensitive g-proteins , only a pt-insensitive g-protein appears to mediate thrombin action in umr 106-h5 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
11,
22
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
209,
214
]
} |
four foals , between two and five days of age , were infused intravenously with 0.5 microgram/kg bodyweight of salmonella typhimurium endotoxin ( lps ) over a 5 h period . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
134,
143
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
146,
149
]
} |
six healthy two-day-old foals ( 3 pony foals and 3 horse foals ) were given a single intravenous ( iv ) injection of trimethoprim ( tmp ) -- sulphamethoxazole ( smz ) at a dosage of 2.5 mg of tmp/kg bodyweight ( bwt ) and 12.5 mg of smz/kg bwt . | NA | {
"id": "C0041044",
"name": "trimethoprim",
"pos": [
117,
129
]
} | {
"id": "C0038689",
"name": "smz",
"pos": [
233,
236
]
} |
interaction in situ of the cytoskeletal protein vinculin with bilayers studied by introducing a photoactivatable fatty acid into living chicken embryo fibroblasts . | NA | {
"id": "C0010852",
"name": "cytoskeletal protein",
"pos": [
27,
47
]
} | {
"id": "C0085175",
"name": "vinculin",
"pos": [
48,
56
]
} |
the cytoskeletal protein vinculin , a putative actin -- plasma-membrane linker , has been shown by hydrophobic photo-labeling to interact in vitro directly with bilayers of acidic phospholipids [ niggli et al . ( 1986 ) j. biol . chem . 261 , 6912-6918 ] . | NA | {
"id": "C0010852",
"name": "cytoskeletal protein",
"pos": [
4,
24
]
} | {
"id": "C0085175",
"name": "vinculin",
"pos": [
25,
33
]
} |
to investigate further the molecular properties of endothelin receptor , the 125i-endothelin-1-endothelin-receptor complex was solubilized from chick cardiac membranes using the detergent digitonin . | NA | {
"id": "C0059285",
"name": "endothelin receptor",
"pos": [
51,
70
]
} | {
"id": "C0217843",
"name": "endothelin-1",
"pos": [
82,
94
]
} |
since these exogenous 1,2-diacylglycerols at the same high concentration also inhibited 125i-insulin binding to the insulin receptor of the intact u-937 and im-9 cells , diacylglycerols could modulate the function of the insulin receptor and insulin action in human mononuclear cells . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
93,
100
]
} | {
"id": "C0795635",
"name": "insulin",
"pos": [
242,
249
]
} |
the protein-coding sequence consists of 2832 bp ( 944 codons , including the aug start codon and the uaa stop codon ) . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
54,
60
]
} | {
"id": "C0242610",
"name": "start codon",
"pos": [
81,
92
]
} |
the protein-coding sequence of the gene consists of 1200 bp ( 400 codons , including the aug start codon and the uga stop codon ) . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
66,
72
]
} | {
"id": "C0242610",
"name": "start codon",
"pos": [
93,
104
]
} |
analysis of the protein isolated from bone demonstrated the presence of sialic acid and , while amino-terminal sequence analysis and internal tryptic fragment sequence analysis of about 25 % of the protein revealed little similarity to the rat phosphoprotein osteopontin , a conserved nine-residue sequence spanning the arg-gly-asp cell-binding site of the rat protein osteopontin , was identified in the approximately 66-kda chicken protein . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
244,
258
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
434,
441
]
} |
at each glycosylation site , the substituents were found to be heterogeneous including , at asn334/341 and asn410 , substitution by different classes of n-glycans : oligomannosidic oligosaccharides , mainly man alpha 1 -- -- 6 ( man alpha 1 -- -- 3 ) man alpha 1 -- -- 6 ( man alpha 1 -- -- 3 ) man beta 1 -- -- 4glcnac beta 1 -- -- 4glcnac beta 1 -- -- , were detected at asn168 , asn334/341 and asn410 . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
155,
162
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
181,
197
]
} |
by also taking into account some recent results on other nucleoside 5'-monophosphate complexes , the following trend for an increasing stacking tendency of the nucleic base moieties can be established : uracil approximately less than cytosine approximately less than thymine much less than adenine less than 7-deazaadenine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
203,
209
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
267,
274
]
} |
the antigenic determinants for three monoclonal antibodies against cytochrome c2 from rhodospirillum rubrum were partially characterized by differential chemical modification of free and antibody-bound cytochrome c2 and by cross-reactivity analysis with different antigens . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
4,
26
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
264,
272
]
} |
the antigenic determinants for three monoclonal antibodies against cytochrome c2 from rhodospirillum rubrum were partially characterized by differential chemical modification of free and antibody-bound cytochrome c2 and by cross-reactivity analysis with different antigens . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
37,
58
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
187,
195
]
} |
a preliminary analysis of the polyclonal immune response of five rats against cytochrome c2 indicates that , unlike in eukaryotic cytochrome c , antigenic determinants are distributed over the whole polypeptide chain of the prokaryotic immunogen . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
145,
167
]
} | {
"id": "C0003320",
"name": "immunogen",
"pos": [
236,
245
]
} |
the mutant proteins studied here all have pseudo ef-hands with a lower calcium-binding constant and a higher calcium off-rate to the pseudo ef-hand than the wild-type protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
4,
19
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
167,
174
]
} |
before therapy an abnormal ca response to light consisting of a rise in epinephrine excretion and a depression in norepinephrine ( ne ) excretion was noticed in migrainous patients . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
114,
128
]
} |
after propranolol administration ( 60 mg daily for 10 days ) the post-photic augmentation in epinephrine excretion and the post-photic depression in ne excretion no longer occurred . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
149,
151
]
} |
pseudotumor cerebri , or increased intracranial pressure without a mass lesion , has been associated with hormonal activity but the exact causative relation is still obscure . | NA | {
"id": "C0033845",
"name": "pseudotumor cerebri",
"pos": [
0,
19
]
} | {
"id": "C0151740",
"name": "increased intracranial pressure",
"pos": [
25,
56
]
} |
one example is scatter factor ( sf ) , a soluble protein ( s ) produced by cultured fibroblasts and vascular smooth muscle cells which causes spreading and separation ( `` '' scattering '' '' ) of tight , cohesive colonies of epithelial cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
84,
95
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
237,
242
]
} |
an increase in the intracellular concentration of cyclic amp by addition of dbcamp ( but not dbcgmp ) caused rapid f-actin redistribution that nonetheless differed from the ngf-induced effect . | NA | {
"id": "C0001455",
"name": "cyclic",
"pos": [
50,
56
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
76,
82
]
} |
the synthetic diacylglycerol 1-oleoyl-2-acetyl-rac-glycerol and the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) have been used in pure rat peritoneal mast cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
68,
81
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
82,
118
]
} |
collectively these data suggest a role for integrin collagen receptors with affinity for collagen fibers , distinct from the previously described rgd-dependent fibronectin receptors , in the fibronectin-independent pdgf-stimulated collagen gel contraction process . | NA | {
"id": "C0021701",
"name": "integrin",
"pos": [
43,
51
]
} | {
"id": "C0060377",
"name": "fibronectin receptors",
"pos": [
160,
181
]
} |
while steroid receptors ( e.g. , progesterone receptors ) appear to be exclusively nuclear , we find p59 predominantly in the cell nuclei and hsp90 in both the nucleus and the cytoplasm . | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
6,
23
]
} | {
"id": "C0034833",
"name": "progesterone receptors",
"pos": [
33,
55
]
} |
flow cytometric multiparameter analysis of two proliferation-associated nuclear antigens ( proliferating cell nuclear antigen ( pcna ) /cyclin and ki-67 ) was performed on seven human hematopoietic cell lines . | NA | {
"id": "C0069115",
"name": "nuclear",
"pos": [
72,
79
]
} | {
"id": "C0072108",
"name": "cyclin",
"pos": [
136,
142
]
} |
also , g0 cells could be discriminated from g1 cells in analysis of a mixture of resting peripheral mononuclear blood cells and a proliferating cell line . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
} | {
"id": "C1321301",
"name": "peripheral mononuclear blood cells",
"pos": [
89,
123
]
} |
pa inhibitor type 1 was deposited onto the extracellular matrix of the keratinocyte cultures and formed a complex with cell-associated tpa when cells and matrix were extracted together . | NA | {
"id": "C0022567",
"name": "cultures",
"pos": [
84,
92
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
144,
149
]
} |
glycosaminoglycan ( gag ) chain characterization indicated about 78 % chondroitin sulfate , 7 % dermatan sulfate , and about 14 % heparan sulfate ( hs ) . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
0,
17
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
130,
145
]
} |
we conclude that the transport capillary endothelium of the liver can synthesize hs proteoglycans which are membrane-associated and this ma-hs pool can bind transferrin . | NA | {
"id": "C0062503",
"name": "hs proteoglycans",
"pos": [
81,
97
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
140,
142
]
} |
because sba seems to have a broad specificity for bl cells with concomitant enrichment in hematopoietic progenitor cells , the use of sba-coated magnetic beads could be of interest for autologous bmt for lymphomas as well as other hematological malignancies and solid tumors with positive binding to sba . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
53,
58
]
} | {
"id": "C0018956",
"name": "hematopoietic progenitor cells",
"pos": [
90,
120
]
} |
crosslinked complexes immunoprecipitated with mab.5b1 and then reduced with dtt were immunoblotted with antibody directed against three soluble p. falciparum antigens , a serine-rich antigen known as pf126 or sera , the s-antigen , and gbp-130 . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
46,
49
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
104,
112
]
} |
the o2- and ca2 ( + ) -paradoxes have a number of features in common and it is suggested that release of cytosolic proteins in both paradoxes is initiated by the activation of a sarcolemma nad ( p ) h dehydrogenase which can generate a transmembrane flow of h+ and e- and also oxygen radicals or redox cycling which damage ion channels and membrane proteins ( phase i ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
115,
123
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
340,
357
]
} |
however , the fact that the aug codon is not present in psbc from several other organisms , whereas a gug codon 14 bases upstream from the end of psbd-i is strictly conserved suggests that cp43 translation starts at the latter codon . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
32,
37
]
} | {
"id": "C0242610",
"name": "starts",
"pos": [
206,
212
]
} |
using antisera reactive with pkc alpha , beta 1 , and beta 2 and gamma , it was observed that t cells expressed two pkc isotypes , pkc alpha and beta 1 . | NA | {
"id": "C0033634",
"name": "pkc",
"pos": [
29,
32
]
} | {
"id": "C0256371",
"name": "pkc alpha",
"pos": [
131,
140
]
} |
the gene product is functionally active when supplemented with thioredoxin and immunologically related with the wild type enzyme . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
4,
16
]
} | {
"id": "C0039938",
"name": "thioredoxin",
"pos": [
63,
74
]
} |
longitudinal sr , junctional sr and t-tubule membranes yielded about 9 , 14 and 3.3 micrograms of egta-soluble proteins per 1 mg of membrane protein , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
111,
119
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
132,
148
]
} |
the immunodominant regions in the formate dehydrogenase molecule and the epitopes for the monoclonal antibodies were elucidated . | NA | {
"id": "C0079600",
"name": "immunodominant regions",
"pos": [
4,
26
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
73,
81
]
} |
spect was abnormal more frequently in degenerative brain diseases ( 82 per cent ) , than in epilepsy ( 63 per cent ) , encephalitis ( 62 per cent ) , cerebrovascular disease ( 43 per cent ) , or other brain disorders ( 43 per cent ) . | NA | {
"id": "C0007820",
"name": "cerebrovascular disease",
"pos": [
150,
173
]
} | {
"id": "C0006111",
"name": "brain disorders",
"pos": [
201,
216
]
} |
19 infants ( 15 per cent ) had significant ophthalmic abnormalities , including reduced visual acuity ( 11 ) , squints ( 13 ) , disorders of supranuclear eye-movement ( three ) and retinal abnormalities ( eight ) . | NA | {
"id": "C0038379",
"name": "squints",
"pos": [
111,
118
]
} | {
"id": "C0028850",
"name": "disorders",
"pos": [
128,
137
]
} |
in lipoprotein-free medium , apolipoproteins a-i , a-ii , b , c , and e accumulate in the medium together with cholesterol , cholesteryl ester , triglyceride , and all the primary bile acids . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
111,
122
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
125,
142
]
} |
when cultured along with mature adipocytes the islets give rise to cells , initially fibroblast-like , which rapidly proliferate , acquire lipid droplets , and differentiate into small adipocytes within 4-6 days without the addition to the medium of the agents usually required to produce differentiation in stromal-vascular preadipocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
67,
72
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
85,
95
]
} |
to determine if an equivalent response occurs with individual components of a mixed meal , somatostatin-28 and prosomatostatin , somatostatin-14 , and somatostatin-13 , in combination , were measured in healthy men before and after intake of ( a ) a mixed meal ( 715 kcal ) , ( b ) carbohydrate ( 100 g equivalent glucose ) , ( c ) protein ( 22 and 45 g ) , and ( d ) fat ( 25 and 50 g ) . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
91,
106
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
151,
163
]
} |
in addition , peripheral blood mononuclear cells derived from patients with ulcerative colitis produced significantly more soluble interleukin-2 receptor upon mitogenic stimulation with phytohemagglutinin ( 2314 +/- 936 u/ml ) , than cells from healthy controls ( 1523 +/- 1152 u/ml ; p less than 0.05 ) . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
14,
48
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
antagonists of dopamine receptors ( benzamides , phenotiazines , butyrophenones and domperidone ) induce adverse reactions in cns ( mainly extrapyramidal disorders ) , which are scarce with metoclopramide and practically absent with domperidone . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
36,
46
]
} | {
"id": "C0025853",
"name": "metoclopramide",
"pos": [
190,
204
]
} |
pharmacological differentiation of presynaptic m1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum . | NA | {
"id": "C0531859",
"name": "m1 muscarinic receptors",
"pos": [
47,
70
]
} | {
"id": "C0034826",
"name": "acetylcholine",
"pos": [
82,
95
]
} |
the effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
21,
36
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
87,
97
]
} |
c-reactive protein ( crp ) is an acute phase reactant that appears to have a variety of biologic effects , including stimulation of prostaglandin production by peripheral blood monocytes . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
33,
53
]
} |
the nuclear dna content of 50 ovarian tumors initially diagnosed as granulosa cell tumors was measured by flow cytometry using paraffin-embedded archival material . | NA | {
"id": "C0919267",
"name": "ovarian tumors",
"pos": [
30,
44
]
} | {
"id": "C0018206",
"name": "granulosa",
"pos": [
68,
77
]
} |
all 50 tumors were immunohistochemically tested for expression of intermediate filament proteins vimentin and cytokeratin and epithelial membrane antigen . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
66,
96
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
97,
105
]
} |
all 50 tumors were immunohistochemically tested for expression of intermediate filament proteins vimentin and cytokeratin and epithelial membrane antigen . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
66,
96
]
} | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
110,
121
]
} |
the mean proportion of cells in s-phase was significantly lower in the 76 patients with a 'low grade ' nhl ( 4.4 per cent ) than in the 30 patients with a 'high grade ' nhl ( 13.0 per cent ) ( p less than 0.0001 ) . | NA | {
"id": "C0079747",
"name": "low grade",
"pos": [
91,
100
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
169,
172
]
} |
baseline values of plasma renin activity and immunoreactive angiotensin ii were higher in the aortic root than in the coronary sinus but concentrations of angiotensin i and angiotensin- ( 1-7 ) were similar . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
60,
74
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
173,
184
]
} |
baseline values of plasma renin activity and immunoreactive angiotensin ii were higher in the aortic root than in the coronary sinus but concentrations of angiotensin i and angiotensin- ( 1-7 ) were similar . | NA | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
60,
73
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
173,
184
]
} |
concentrations of angiotensin ii and angiotensin- ( 1-7 ) did not change either in peripheral blood or across the coronary circulation . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
18,
32
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
37,
48
]
} |
we found that , despite having 10-fold higher levels of circulating catecholamines , pheochromocytoma patients have hemodynamic characteristics similar to patients with essential hypertension and that , in individual patients , the ratio of circulating norepinephrine to epinephrine had no relation to the hemodynamic profile . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
253,
267
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
271,
282
]
} |
twenty-four hours later , recordings of mean arterial pressure and heart rate were obtained during injections of 2.5 ng angiotensin ii or angiotensin- ( 1-7 ) in chloralose-urethane-anesthetized rats . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
120,
134
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
138,
149
]
} |
the effects of both angiotensin ii and angiotensin- ( 1-7 ) were blocked by previous administration of the angiotensin ii antagonist [ sar1 , thr8 ] angiotensin ii into the nucleus tractus solitarii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
20,
31
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
149,
163
]
} |
these findings confirm that both angiotensin ii and angiotensin- ( 1-7 ) express biological activity through receptor-mediated actions in the dorsal medulla oblongata . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
33,
47
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
52,
63
]
} |
endogenous blockade of ang ii by saralasin ( 22 ng ) in the nts facilitated the bradycardic response ( -2.29 +/- 0.91 beats/min/mm hg ) . | NA | {
"id": "C0003009",
"name": "ang ii",
"pos": [
23,
29
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
33,
42
]
} |
nitroprusside-induced tachycardia was not altered by saralasin microinjection into the nts or by ang ii application to the nts , fourth ventricle , or intravenously . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
53,
62
]
} | {
"id": "C0003009",
"name": "ang ii",
"pos": [
97,
103
]
} |
both antihypertensive medications were infused at a maximal dose increment of 0.2 microgram/kg/min ( fenoldopam ) and 1 microgram/kg/min ( nitroprusside ) , with a maximal infusion rate of 1.5 micrograms/kg/min fenoldopam mesylate or 8 micrograms/kg/min sodium nitroprusside . | NA | {
"id": "C0060180",
"name": "fenoldopam",
"pos": [
101,
111
]
} | {
"id": "C0700481",
"name": "fenoldopam mesylate",
"pos": [
211,
230
]
} |
both antihypertensive medications were infused at a maximal dose increment of 0.2 microgram/kg/min ( fenoldopam ) and 1 microgram/kg/min ( nitroprusside ) , with a maximal infusion rate of 1.5 micrograms/kg/min fenoldopam mesylate or 8 micrograms/kg/min sodium nitroprusside . | NA | {
"id": "C0028193",
"name": "nitroprusside",
"pos": [
139,
152
]
} | {
"id": "C0037533",
"name": "sodium",
"pos": [
254,
260
]
} |
protection of mice against the lethal toxicity of a lipopolysaccharide ( lps ) by immunization with anti-idiotype antibody to a monoclonal antibody to lipid a from eikenella corrodens lps . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
19,
20
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
184,
187
]
} |
these studies indicate that a2la-1 and a2la-2 contained an antigenic epitope that mimicked lipid a . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
59,
68
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
69,
76
]
} |
mab 4-7b5 ( immunoglobulin m ) and mab 4-6a1 ( immunoglobulin g1 ) cross-reacted with lps of salmonella minnesota r5 and s. typhimurium ra and rc and little with re and lipid a . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
86,
89
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
169,
176
]
} |
antibody 8-2c1 was directed against the common parts of lps , 3-deoxy-d-manno-octulosonic acid , and lipid a , which are not ( or only weakly ) recognized by the four anti-j5 lps mab . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
101,
108
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
175,
178
]
} |
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