text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
among six lectins tested , including concanavalin a , d. biflorus agglutinin , ulex europaeus agglutinin , soybean agglutinin , peanut agglutinin , and wheat germ agglutinin , the latter was the only lectin that did not recognize any chlamydial protein . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
10,
16
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
245,
252
]
} |
the two proteins isolated from a concanavalin a-agarose column maintained their lectin-binding capacities and elicited hemagglutinating properties against mouse erythrocytes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
80,
86
]
} |
one of these monoclonal antibodies of the immunoglobulin m subclass , along with immune chicken sera raised against affinity-purified 56- and 82-kda antigens , was used to passively immunize chicks . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
24,
34
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
81,
87
]
} |
our studies indicate that the b700 protein has weak enzymatic activity for prostaglandin e2 similar to that of albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
35,
42
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
111,
118
]
} |
other progestins such as levonorgestrel , norethisterone and norethisterone acetate also increased predominantly reductive 17 beta-hydroxysteroid oxidoreductase activity in the absence of phenol red . | NA | {
"id": "C0028356",
"name": "norethisterone",
"pos": [
42,
56
]
} | {
"id": "C0068980",
"name": "norethisterone acetate",
"pos": [
61,
83
]
} |
hpv54 was isolated from a verrucous carcinoma ( buschke-lowenstein tumour ) together with full-length hpv6 genomes and hpv6 dna molecules with a deletion of about 0.3 kb located in the non-coding region . | NA | {
"id": "C0206706",
"name": "verrucous carcinoma",
"pos": [
26,
45
]
} | {
"id": "C0276264",
"name": "buschke-lowenstein tumour",
"pos": [
48,
73
]
} |
electron-immunocytochemical staining for three intermediate filament ( if ) proteins , keratin ( k ) , glial fibrillary acidic protein ( gfap ) , and vimentin ( v ) , and for the macrophage marker , ebm/11 ( e ) , was performed on epiretinal membranes obtained during vitrectomies performed for proliferative vitreoretinopathy ( pvr ) , postdetachment macular puckers ( pdmps ) , idiopathic macular puckers ( imps ) , or macular puckers associated with other disease processes . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
47,
68
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
87,
94
]
} |
electron-immunocytochemical staining for three intermediate filament ( if ) proteins , keratin ( k ) , glial fibrillary acidic protein ( gfap ) , and vimentin ( v ) , and for the macrophage marker , ebm/11 ( e ) , was performed on epiretinal membranes obtained during vitrectomies performed for proliferative vitreoretinopathy ( pvr ) , postdetachment macular puckers ( pdmps ) , idiopathic macular puckers ( imps ) , or macular puckers associated with other disease processes . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
47,
68
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic protein",
"pos": [
103,
134
]
} |
electron-immunocytochemical staining for three intermediate filament ( if ) proteins , keratin ( k ) , glial fibrillary acidic protein ( gfap ) , and vimentin ( v ) , and for the macrophage marker , ebm/11 ( e ) , was performed on epiretinal membranes obtained during vitrectomies performed for proliferative vitreoretinopathy ( pvr ) , postdetachment macular puckers ( pdmps ) , idiopathic macular puckers ( imps ) , or macular puckers associated with other disease processes . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
47,
68
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
150,
158
]
} |
5 ) undifferentiated , pigment-laden cells that rarely stained for any of the above if proteins , but occasionally showed k or v positivity in a portion of the cell , suggesting that they may be losing or acquiring these proteins , and that rarely expressed gfap ; | NA | {
"id": "C0021769",
"name": "if proteins",
"pos": [
84,
95
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
258,
262
]
} |
angiotensin binding sites in membrane homogenates of rabbit iris/ciliary body and human nonpigmented ciliary epithelial ( npe ) cells grown in culture were characterized using radioligand binding assays with ( 125i ) -sarcosine1-isoleucine8-angiotensin ii [ ( 125i ) -sarile ] . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
241,
255
]
} | {
"id": "C0000107",
"name": "sarile",
"pos": [
268,
274
]
} |
studies of the inhibition of the binding of ( 125i ) -sarile in rabbit iris/ciliary body were performed with a series of competing ligands , including the angiotensin receptor antagonist sarile and the agonists angiotensin i , angiotensin ii and angiotensin iii . | NA | {
"id": "C0000107",
"name": "sarile",
"pos": [
54,
60
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
246,
260
]
} |
estimation of inhaled radiation doses associated with mineral sands processing is commonly performed by gross alpha-counting dust collected on air filters . | NA | {
"id": "C0026162",
"name": "mineral",
"pos": [
54,
61
]
} | {
"id": "C0037098",
"name": "sands",
"pos": [
62,
67
]
} |
a marquette augmented cardiograph was used to obtain 12-lead electrocardiogram ( ecgs ) at baseline and at 3 , 10 , and 25 minutes after ingestion of 200 or 400 ml ice water . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
164,
167
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
168,
173
]
} |
we have isolated and characterized two minor extracellular proteases from culture supernatants of a strain of bacillus subtilis containing deletion mutations of the genes for the extracellular proteases subtilisin ( apr ) and neutral protease ( npr ) and a minor extracellular protease ( epr ) as well as intracellular serine protease-i ( isp-1 ) . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
59,
68
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
326,
334
]
} |
we have isolated and characterized two minor extracellular proteases from culture supernatants of a strain of bacillus subtilis containing deletion mutations of the genes for the extracellular proteases subtilisin ( apr ) and neutral protease ( npr ) and a minor extracellular protease ( epr ) as well as intracellular serine protease-i ( isp-1 ) . | NA | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
203,
213
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
319,
334
]
} |
we have isolated and characterized two minor extracellular proteases from culture supernatants of a strain of bacillus subtilis containing deletion mutations of the genes for the extracellular proteases subtilisin ( apr ) and neutral protease ( npr ) and a minor extracellular protease ( epr ) as well as intracellular serine protease-i ( isp-1 ) . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
59,
67
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
319,
334
]
} |
character states of aromatic amino acid biosynthesis are used as criteria , and the results are compared with partial trees based upon sequencing of 16s rrna , 5s rrna , and tryptophan leader peptide . | NA | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
20,
39
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
174,
184
]
} |
foca encodes the major fimbrial subunit , focc encodes a product that is indispensable for fimbria formation , focg and foch encode minor fimbrial subunits , and foci encodes a protein which shows similarities to the subunit protein foca . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} | {
"id": "C0599220",
"name": "subunit protein",
"pos": [
217,
232
]
} |
the ethidium bromide-staining method was particularly suitable for staining lipopolysaccharides possessing acidic o-specific polysaccharides , which were poorly visualized by silver staining . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
76,
95
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharides",
"pos": [
114,
140
]
} |
the lps of both mutants lacked o antigen and some sugar residues of the lps core oligosaccharides . | NA | {
"id": "C0069180",
"name": "o antigen",
"pos": [
31,
40
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
72,
75
]
} |
in this case the resulting lps contained o-antigen sugars characteristic of donor strain cfn42 and reacted weakly with antiserum against cfn42 cells , but did not react detectably with antiserum against anu843 cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
27,
30
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
41,
50
]
} |
both mutants elicited normally developed , nitrogen-fixing clover nodules when they carried cfn42 lps dna that permitted synthesis of o-antigen-containing lps , regardless of whether the o antigen was the one originally made by strain anu843 . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
98,
101
]
} | {
"id": "C0069180",
"name": "o",
"pos": [
209,
210
]
} |
a family of genes encode the multiple forms of the saccharomyces cerevisiae ribosomal proteins equivalent to the escherichia coli l12 protein and a single form of the l10-equivalent ribosomal protein . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
76,
94
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
192,
199
]
} |
we have developed an effective method to delete or invert a chromosomal segment and to create reciprocal recombination between two nonhomologous chromosomes in saccharomyces cerevisiae , using the site-specific recombination system of psr1 , a circular cryptic dna plasmid resembling 2 microns dna of s. cerevisiae but originating from another yeast , zygosaccharomyces rouxii . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
244,
252
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
294,
297
]
} |
the b subunit of shiga toxin and the shiga-like toxins ( slts ) mediates receptor binding , cytotoxic specificity , and extracellular localization of the holotoxin . | NA | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
17,
28
]
} | {
"id": "C0148323",
"name": "shiga-like toxins",
"pos": [
37,
54
]
} |
the levels of two aspartokinase isozymes , a lysine-sensitive enzyme and an aspartokinase that is inhibited synergistically by lysine plus threonine , differ strikingly in different strains of bacillus subtilis . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
32,
40
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
62,
68
]
} |
reactivation of inactivated nitrogenase and concomitant demodification of dinitrogenase reductase occurred after restoration of diazotrophic growth conditions . | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
28,
39
]
} | {
"id": "C0085544",
"name": "dinitrogenase reductase",
"pos": [
74,
97
]
} |
the other anthranilate synthase enzyme , encoded by phna and phnb , participates in the synthesis of pyocyanin , the characteristic phenazine pigment of the organism . | NA | {
"id": "C0034211",
"name": "pyocyanin",
"pos": [
101,
110
]
} | {
"id": "C0031375",
"name": "phenazine",
"pos": [
132,
141
]
} |
in order to study the structure and function relationships of the thyrotropin ( tsh ) -specific beta-subunit , we produced 11 synthetic overlapping peptides containing the entire 112-amino acid sequence of human beta tsh and tested them for activity in tsh radioreceptor assay using both human and porcine thyroid membranes . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
66,
77
]
} | {
"id": "C0076641",
"name": "beta tsh",
"pos": [
212,
220
]
} |
binding of 125i-labeled ovine crf to leydig cell membranes was reduced by gtp and guanyl-5'-yl imidodiphosphate ( gpp ( nh ) p ) , in a dose-dependent manner . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
74,
77
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
114,
126
]
} |
when [ cu2+ ] was 10 microm and the cu : l ratio was increased from 1:2 to 1:2,000 , gln , glu , gly , lys , or ser was each superior to his in facilitating 67cu uptake . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
85,
88
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
91,
94
]
} |
moreover , by comparison to 67cu uptake at a cu : l ratio of 1:2 , increasing the ratio attenuated ( his ) or enhanced ( gln , glu , gly , lys , ser ) 67cu uptake . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
121,
124
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
127,
130
]
} |
at the same position as the camp-responsive element in the rat gene , the mouse and human tpa genes have a 12-o-tetradecanoylphorbol-13-acetate-responsive element known to mediate activation by phorbol esters . | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
107,
143
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
194,
208
]
} |
however , given the possible role of variable dynamics in epitope formation , these results do not preclude crucial roles in antibody recognition for regions on the 19-9 antigen that are distanced from neuac . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
58,
65
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
170,
177
]
} |
in contrast , levels of expression and subcellular distribution of immunoreactive pkc beta and pkc gamma , as well as levels of mrna specific for the three pkc isoenzymes , were not significantly affected by chronic pe treatment . | NA | {
"id": "C0257291",
"name": "pkc beta",
"pos": [
82,
90
]
} | {
"id": "C0033634",
"name": "pkc",
"pos": [
156,
159
]
} |
several enzymes including 3 alpha-hydroxysteroid dehydrogenase ( 3 alpha-hsd ) , 3 beta-hydroxysteroid dehydrogenase ( 3 beta-hsd ) , 3-ketosteroid reductase , and dihydrodiol dehydrogenase eluted mainly in the 30,000-40,000 mr fractions known to contain the newly identified bile acid binder ( stolz , a. , sugiyama , y. , kuhlenkamp , j. , and kaplowitz , n. ( 1984 ) febs lett . 177 , 31-35 ) . | NA | {
"id": "C0048751",
"name": "3 alpha-hydroxysteroid dehydrogenase",
"pos": [
26,
62
]
} | {
"id": "C0000413",
"name": "3",
"pos": [
391,
392
]
} |
the activation in vitro of dioxin and glucocorticoid receptors from a non-dna binding to a dna binding state was characterized . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
74,
77
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
89,
94
]
} |
smg p25a gdi also inhibited the binding of gtpgamma s to the gdp-bound form of smg p25a but not of that to the guanine nucleotide-free form . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
61,
64
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
111,
129
]
} |
among adolescents and young adults , injury and poisoning , together with tuberculosis and other infectious and parasitic diseases , were the leading causes of death . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
97,
107
]
} | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
112,
130
]
} |
twenty-four fractures were severely comminuted , and the other 16 , in the distal or proximal third of the shaft , were classified as unstable . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
12,
21
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
36,
46
]
} |
when human fibroblasts are incubated for 2-5 min with 20 microm [ 35s ] cystine in krebs-ringer phosphate solution at ph 7.4 , a minimum of 50-60 % of the total radioactivity taken up by the cells is found sequestered into the lysosomal compartment in the form of cysteine . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
11,
22
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
191,
196
]
} |
carrier mediation by this lysosomal transport route demonstrates a high specificity for cysteine as indicated by the inability of the following amino acids to significantly inhibit at 5 mm the lysosomal uptake of 0.035 mm [ 35s ] l-cysteine : ala , ser , pro , val , gly , homocysteine , d- or l-penicillamine , arg , asp , or leu . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
144,
149
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
267,
270
]
} |
( msh-induced responses included changes in tyrosinase , dopa oxidase , and dopachrome conversion factor activities , melanization , proliferation , and morphology . ) | NA | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
44,
54
]
} | {
"id": "C0041484",
"name": "dopa oxidase",
"pos": [
57,
69
]
} |
the effect of the phorbol ester tumor promoter 12-o-tetradecanoylphorbol 13-acetate ( tpa ) on cell invasion was studied using an in vitro assay for cell invasion through a reconstituted basement membrane matrix ( matrigel ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
18,
31
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol",
"pos": [
47,
72
]
} |
mutants of type 5 adenovirus that lack all or part of the early region 1a ( e1a ) gene enhancer element transform rodent embryo fibroblast ( cref ) cells at higher efficiencies than wild-type virus . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
128,
138
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
these findings establish previously unrecognized properties of ischemic astrocytes that may be prerequisites for infarction from nearly complete ischemia : the capacity to develop profound cellular acidosis and a concomitant reduction in cell membrane ion permeability . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
113,
123
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
145,
153
]
} |
since available fixatives often did not provide simultaneous preservation of optimal protein and peptide immunoreactivities , a new fixative , buffered periodate-paraformaldehyde-picric acid-formaldehyde-lysine ( pppfl ) , was formulated and tested . | NA | {
"id": "C0070066",
"name": "picric",
"pos": [
179,
185
]
} | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
191,
203
]
} |
[ 2-3h ] galactose was also administered , so the 3h/14c ratio in blood glucose measured the extent of equilibration of glucose-6-p with fructose-6-p . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
63,
79
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
120,
127
]
} |
this patient with isosexual precocity has pcr , as indicated by functionally abnormal glucocorticoid receptors and hypercortisolism without other clinical or biochemical manifestations of cushing 's syndrome . | NA | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
115,
131
]
} | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
188,
207
]
} |
additionally , sp contains a non-glycosylated low molecular weight igf-bp ( 24k ) , which does not appear to be structurally or immunologically related to igf-bp-1 , -2 or -3 . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
67,
70
]
} | {
"id": "C0021665",
"name": "igf",
"pos": [
155,
158
]
} |
we have now studied the kinetics of this response in adult normal , neonatally capsaicin-pretreated and neonatally capsaicin-pretreated substance p-infused rats , and examined the effects of the tachykinin antagonist spantide , on the plaque-forming cell response . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
136,
147
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
195,
205
]
} |
the smallest epitopes that were strongly antigenic and recognized by greater than 70 % of sera tested ( immunodominant ) were encoded by the subclones bgx and xa located in the 5 ' and 3 ' halves of the la cdna , respectively . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
13,
21
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
41,
50
]
} |
activated macrophages release tissue forms of insulin-like growth factor i ( igf-i ) , 20-25-kd products of the igf-i gene , thus providing an extracellular growth and differentiation signal at sites of inflammation . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
77,
82
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
112,
115
]
} |
northern analysis and rnase protection analysis with 32p-labeled igf-i-specific probes demonstrated that the igf-i mrna transcripts of resting u937 cells were similar in size and amount to those of resting human alveolar macrophages , mononuclear phagocytes known to express the igf-i gene . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
65,
68
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
279,
284
]
} |
this specificity suggests that understanding the antigenic epitopes and immunoregulation governing the production of ajoa may result in clues to disease pathogenesis . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
49,
58
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
59,
67
]
} |
these findings suggest that ajoa are induced by an antigen-driven mechanism , bind to a common epitope or epitopes on hrs , and are modulated by an immune response closely linked to that which is responsible for myositis in these patients . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
51,
58
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
106,
114
]
} |
insulin-stimulated glycogen synthase activity in human skeletal muscle correlates with insulin-mediated glucose disposal rate ( m ) and is reduced in insulin-resistant subjects . | NA | {
"id": "C0795635",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
150,
157
]
} |
transforming growth factor-beta 1 ( tgf beta 1 , 1 ng/ml ) and basic fibroblast growth factor ( fgf , 25 ng/ml ) elicited changes corresponding to those induced by hemodynamic load . | NA | {
"id": "C0380603",
"name": "basic fibroblast growth factor",
"pos": [
63,
93
]
} | {
"id": "C0016026",
"name": "fgf",
"pos": [
96,
99
]
} |
the `` '' fetal '' '' beta-myosin heavy chain ( mhc ) was up-regulated about four-fold , whereas the `` '' adult '' '' alpha mhc was inhibited greater than 50-60 % ; | NA | {
"id": "C0027100",
"name": "a-myosin heavy cha",
"pos": [
25,
43
]
} | {
"id": "C0027096",
"name": "pha",
"pos": [
121,
124
]
} |
these results suggest that anti-la antibodies are coordinately produced to different epitopes on the la molecule , possibly reflecting an antigen-driven mechanism . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
85,
93
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
138,
145
]
} |
the regional distribution of opiate receptors as determined by 3h-naloxone binding is similar in human infants to that reported in human adults and animals and corresponds most closely to that of mu receptors . | NA | {
"id": "C0034801",
"name": "opiate receptors",
"pos": [
29,
45
]
} | {
"id": "C0066908",
"name": "mu receptors",
"pos": [
196,
208
]
} |
growth hormone releasing factor ( grf ) neurons in the arcuate nucleus of the hypothalamus and somatostatin ( srif ) neurons in the anterior periventricular region of the hypothalamus act to control the release of growth hormone from the anterior pituitary . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
0,
14
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
238,
256
]
} |
our findings indicated that students are reasonably well informed about aids , are aware of the recommended precautions for avoiding hiv infection , and are fearful that the virus may spread within the student population . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
72,
76
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
133,
146
]
} |
their supraventricular tachycardia did not involve a slowly conducting paraseptal accessory pathway because the distal av node , his bundle and ventricle were not found to be necessary links in the tachycardia circuit . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
6,
34
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
198,
209
]
} |
six patients are described with a history of cold-related urticaria in whom standard tests ( water-immersion and ice-cube ) did not induce symptoms . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
93,
98
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
113,
116
]
} |
the seizure disorders treated included photosensitive epilepsy ( one case ) , acquired epileptic aphasia ( one case ) , lennox-gastaut syndrome ( three cases ) , and symptomatic localization-related epilepsies ( six cases ) . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
87,
96
]
} | {
"id": "C0238111",
"name": "lennox-gastaut syndrome",
"pos": [
120,
143
]
} |
purpura fulminans is a rare disease that typically begins as a benign infectious process and subsequently progresses to severe sepsis , hypotension , purpura ecchymosis , and disseminated intravascular coagulation . | NA | {
"id": "C0085650",
"name": "purpura fulminans",
"pos": [
0,
17
]
} | {
"id": "C0034150",
"name": "purpura",
"pos": [
150,
157
]
} |
ultra-thin sections of embedded tissue were stained with a monoclonal primary antibody and colloidal gold-labeled secondary antibody , followed by 2 % osmium tetroxide and lead citrate . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
59,
69
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
124,
132
]
} |
however , no staining was seen in tumor cells secreting no g-csf , untransfected cho cells , lung fibroblasts , or bone marrow stromal cells after short periods of culture . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
135,
140
]
} |
changes in total dna and viral dna through time were followed by fluorescence spectroscopy and quantitative slot-blot dna : dna hybridization , respectively . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
25,
34
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
124,
127
]
} |
total dna content ( i.e. , larval dna and viral dna ) of larvae infected with the intermediate dose lagged behind that of noninfected larvae 30 hr post-inoculation ( p.i ) , reached a maximum at 51 hr p.i. , and stayed constant thereafter . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
6,
9
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
42,
51
]
} |
transforming growth factors beta ( tgf-beta 1 , tgf-beta 2 ) mediate the inhibition of epithelial cell proliferation and the induction of fibronectin and collagen gene expression . | NA | {
"id": "C0040690",
"name": "transforming growth factors beta",
"pos": [
0,
32
]
} | {
"id": "C0079441",
"name": "tgf-beta 2",
"pos": [
48,
58
]
} |
hiv-specific adcc and neutralizing antibodies do not seem to protect against transmission of hiv from mother to child but are significantly correlated with a better clinical stage of childhood hiv infection . | NA | {
"id": "C0021051",
"name": "hiv",
"pos": [
0,
3
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
193,
206
]
} |
novel sulfated polysaccharides , sulfated bacterial glycosaminoglycan ( org 31581 ) and chemically degraded heparin ( org 31733 ) , have proved to be potent and selective inhibitors of human immunodeficiency virus ( hiv ) in vitro . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
52,
69
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
108,
115
]
} |
such lysozyme-dependent antistaphylococcal activity was manifested specifically with beta-lactams ( 9 penicillins , 10 cephalosporins , 3 cephamycins , 1 oxacephem , and 1 carbapenem ) . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
85,
97
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
102,
113
]
} |
such lysozyme-dependent antistaphylococcal activity was manifested specifically with beta-lactams ( 9 penicillins , 10 cephalosporins , 3 cephamycins , 1 oxacephem , and 1 carbapenem ) . | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
85,
97
]
} | {
"id": "C0006968",
"name": "carbapenem",
"pos": [
172,
182
]
} |
such lysozyme-dependent antistaphylococcal activity was manifested specifically with beta-lactams ( 9 penicillins , 10 cephalosporins , 3 cephamycins , 1 oxacephem , and 1 carbapenem ) . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
119,
133
]
} | {
"id": "C0007736",
"name": "cephamycins",
"pos": [
138,
149
]
} |
it is concluded that a. haemolyticum is often penicillin-tolerant , suggesting that phenoxymethylpenicillin administration would be ineffective in eradicating a. haemolyticum from the pharynx . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
46,
56
]
} | {
"id": "C0030840",
"name": "phenoxymethylpenicillin",
"pos": [
84,
107
]
} |
removal of the excess nuclear protein from cells in the three physiological states differed both in the percentage of the population that could remove the protein and the rate at which the protein was removed . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
22,
37
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
189,
196
]
} |
while all of the qm and qtt cells removed the excess nuclear protein , approximately 30 % of the q cells did not remove the excess nuclear protein , and continued to accumulate protein over the 48 h after the heat treatment . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
53,
68
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
plasma samples from one pregnant patient were studied serially by functional and quantitative immunochemical assays as well as immunoblot assays for high molecular weight kininogen ( hmwk ) and/or prekallikrein/kallikrein ( pk/k ) . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
197,
210
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
211,
221
]
} |
that this patient 's plasma during her pregnancy was contact activated was determined by additional immunoblot studies for pk/k . | NA | {
"id": "C0033024",
"name": "pk/k",
"pos": [
123,
127
]
} | {
"id": "C0022478",
"name": "pk/k",
"pos": [
123,
127
]
} |
immunoblot assay for plasma pk/k revealed kallikrein-alpha 2-macroglobulin complexes and a 50 kd pk/k form seen only in activated plasma samples . | NA | {
"id": "C0022478",
"name": "pk/k",
"pos": [
28,
32
]
} | {
"id": "C0033024",
"name": "pk/k",
"pos": [
97,
101
]
} |
the findings of kallikrein-alpha 2-macroglobulin complexes and a 50 kd pk/k form disappeared after delivery . | NA | {
"id": "C0033024",
"name": "pk/k",
"pos": [
71,
75
]
} | {
"id": "C0022478",
"name": "pk/k",
"pos": [
71,
75
]
} |
unlike rbc autoantibodies from antiglobulin-positive normal blood donors , autoantibodies from patients with autoimmune hemolytic anemia did not show rh-dependent properties as judged by antigen site density , absence of differential binding to rbc of different rh phenotypes , failure to immunoprecipitate 30 kd rh-epitope bearing membrane polypeptides , absence of multiple antibody populations , and the lack of a significant nonadsorbable igg population that has been associated with the presence of antiidiotypic igg . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
187,
194
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
316,
323
]
} |
platelets were prelabeled with [ 3h ] inositol so that increases in inositol phosphates ( ip , ip2 , and ip3 ) upon stimulation with thrombin could be assessed by measuring the amount of label in these compounds . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
38,
46
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
68,
87
]
} |
platelets were prelabeled with [ 3h ] inositol so that increases in inositol phosphates ( ip , ip2 , and ip3 ) upon stimulation with thrombin could be assessed by measuring the amount of label in these compounds . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
68,
87
]
} | {
"id": "C0021549",
"name": "ip3",
"pos": [
105,
108
]
} |
developmental patterns of plasma insulin-like growth factor-i ( igf-i ) and body growth in mice from lines divergently selected on the basis of plasma igf-i . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
64,
67
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
151,
156
]
} |
preincubation of cells for 6 h with up to 1 mmol sodium iodide/l led to a progressive reduction in both accumulation of camp and iodide uptake responses to tsh . | NA | {
"id": "C0037521",
"name": "sodium iodide",
"pos": [
49,
62
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
129,
135
]
} |
to assess the prevalence of autonomic neuropathy ( an ) in non-insulin dependent diabetes mellitus ( niddm ) and its relationships with other diabetic complications , duration of diabetes , and obesity , we evaluated 51 niddm patients ( age 41-59 years , mean 49 years , duration of diabetes 0-15 years , mean 6.9 years ) . | NA | {
"id": "C0342257",
"name": "diabetic",
"pos": [
142,
150
]
} | {
"id": "C0011849",
"name": "niddm",
"pos": [
220,
225
]
} |
kinetic analysis of the anion exchange showed that at saturating intracellular oh- , a [ ca2+ ] i increase did not modify the properties of the extracellular site . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
24,
29
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
159,
160
]
} |
a rise in [ ca2+ ] i increased the apparent affinity for intracellular oh- ( or hco3- ) of both net anion and cl- self exchange . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
3,
4
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
100,
105
]
} |
these results indicate that [ ca2+ ] i modifies the interaction of intracellular oh- ( or hco3- ) with the proposed regulatory site of the anion exchanger in umr-106 cells . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
14,
15
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
139,
144
]
} |
the phorbol ester , 12-o-tetradecanoylphorbol 13-acetate ( tpa ) , which causes differentiation of sh-sy5y neuroblastoma cells , reduces carbachol binding and carbachol-stimulated ca2+ mobilization in these cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
20,
56
]
} |
the putative regulatory effect of opioids on adenylate cyclase was investigated in two different preparations containing , respectively , two different populations of opioid receptors : the rabbit cerebellum ( greater than 75 % mu-opioid receptors ) and the guinea pig cerebellum ( greater than 80 % kappa-opioid receptors ) . | NA | {
"id": "C0034801",
"name": "opioid receptors",
"pos": [
167,
183
]
} | {
"id": "C0066908",
"name": "mu-opioid receptors",
"pos": [
228,
247
]
} |
the putative regulatory effect of opioids on adenylate cyclase was investigated in two different preparations containing , respectively , two different populations of opioid receptors : the rabbit cerebellum ( greater than 75 % mu-opioid receptors ) and the guinea pig cerebellum ( greater than 80 % kappa-opioid receptors ) . | NA | {
"id": "C0034801",
"name": "opioid receptors",
"pos": [
167,
183
]
} | {
"id": "C0064239",
"name": "kappa-opioid receptors",
"pos": [
300,
322
]
} |
a general immunodeficiency was noted at baseline , and the lymphopenia worsened with progressing disease , unaffected by therapy . | NA | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
10,
26
]
} | {
"id": "C0024312",
"name": "lymphopenia",
"pos": [
59,
70
]
} |
in contrast to gaba , baclofen consistently induced hyperpolarization in low cl- solution as well as in normal solution . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
15,
19
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
22,
30
]
} |
jpmsd mice have a single base change in plp , a c -- -- t transition in exon 6 that would substitute a valine for alanine in both plp and its alternatively spliced isoform , dm20 . | NA | {
"id": "C0033684",
"name": "plp",
"pos": [
40,
43
]
} | {
"id": "C0597298",
"name": "isoform",
"pos": [
164,
171
]
} |
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