text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
two major dna-binding proteins that bind in a sequence-specific manner to the octamer dna sequence have been identified in mammalian species -- a ubiquitously expressed protein ( oct-1 ) and a lymphoid-specific protein ( oct-2 ) . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
10,
30
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
211,
218
]
} |
by inhibiting the inactivation of plasmin by alpha 2ap , rwr interacts synergistically with plasminogen activators to increase the potency ( for 50 % clot lysis ) of urokinase by 80-fold , tissue plasminogen activator by 27-fold , and streptokinase by 20-fold . | NA | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
92,
114
]
} | {
"id": "C0032143",
"name": "tissue plasminogen",
"pos": [
189,
207
]
} |
by inhibiting the inactivation of plasmin by alpha 2ap , rwr interacts synergistically with plasminogen activators to increase the potency ( for 50 % clot lysis ) of urokinase by 80-fold , tissue plasminogen activator by 27-fold , and streptokinase by 20-fold . | NA | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
92,
114
]
} | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
235,
248
]
} |
the observations that both acidic and basic fgfs had a mitogenic effect on nbt-ii cells and that only acidic fgf caused cell dissociation and dispersion strongly suggest that these two biological activities could be medicated through distinct signaling pathways . | NA | {
"id": "C0016026",
"name": "fgfs",
"pos": [
44,
48
]
} | {
"id": "C0079349",
"name": "acidic fgf",
"pos": [
102,
112
]
} |
inhibition of the l-arginine-dependent pathway by addition of ng-monomethyl-l-arginine ( methyl group on a terminal guanidino nitrogen ) inhibits the production of nitrite , nitrate , citrulline , and the g = 2.039 signal . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
20,
28
]
} | {
"id": "C0069477",
"name": "ng-monomethyl-l-arginine",
"pos": [
62,
86
]
} |
the in vivo activation and turnover rates of the sodium pump ( na+ , k ( + ) -atpase ) were investigated in the electrocytes of the electric organ of the elasmobranch narcine brasiliensis . | NA | {
"id": "C0001479",
"name": "sodium pump",
"pos": [
49,
60
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
78,
84
]
} |
the great difference in accumulation of the mrnas for the two myosin heavy chain isoforms a and b may be related to the different roles of the myosins in thick filament assembly . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
62,
80
]
} | {
"id": "C0027096",
"name": "myosins",
"pos": [
143,
150
]
} |
macrophages express few receptors for normal low density lipoprotein ( ldl ) but can take up oxidized ldl by way of a scavenger receptor . | NA | {
"id": "C0034821",
"name": "receptors",
"pos": [
24,
33
]
} | {
"id": "C0536243",
"name": "oxidized ldl",
"pos": [
93,
105
]
} |
pentamidine , diminazene aceturate ( berenil ) , isometamidium chloride ( samorin ) , and ethidium bromide , which are important antitrypanosomal drugs , promote linearization of trypanosoma equiperdum minicircle dna ( the principal component of kinetoplast dna , the mitochondrial dna in these parasites ) . | NA | {
"id": "C0064360",
"name": "kinetoplast dna",
"pos": [
246,
261
]
} | {
"id": "C0012929",
"name": "mitochondrial dna",
"pos": [
268,
285
]
} |
restriction site variation in dna that encodes rrna ( rdna ) was surveyed among 714 offspring within 31 lineages ( 26 genotypes ) of obligate asexually reproducing taraxacum officinale ( dandelions ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
30,
33
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
54,
58
]
} |
because somatic mutations in plants can be incorporated into reproductive tissue , we propose that somatic events affecting at least both multicopy rdna and dna homologous to the maize adh1 gene occurred at different developmental times in the two families . | NA | {
"id": "C0012933",
"name": "rdna",
"pos": [
148,
152
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
157,
160
]
} |
ctl were generated in vivo by intraperitoneal immunization with p815 cells and in vitro by allogeneic stimulation of cells from animals maintained on a normal diet in media supplemented with 1 x 10 ( -9 ) to 1 x 10 ( -6 ) m se ( as selenite ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
91,
101
]
} |
if successful , identifying cofactors could prove valuable in understanding the pathogenesis of hiv infection and aids and in the development of strategies to prolong survival and/or prevent complications in hiv-infected individuals . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
96,
109
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
114,
118
]
} |
the decline in energy intake , together with its possible consequences for reducing the efficiency of dietary protein utilization , also will tend to increase the protein need for elderly subjects , relative to that for physically more active young adults . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
102,
117
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
163,
170
]
} |
it binds to dna in vivo and in vitro , and a dna adduct has been identified . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
12,
15
]
} | {
"id": "C0242958",
"name": "dna",
"pos": [
45,
48
]
} |
bovine pepsinogens had organic phosphate contents ranging from 1.65 to 2.22 mol of phosphate mol-1 of pepsinogen . | NA | {
"id": "C0030913",
"name": "pepsinogens",
"pos": [
7,
18
]
} | {
"id": "C0077923",
"name": "1",
"pos": [
97,
98
]
} |
a number of studies have suggested that following a prolonged cardiopulmonary arrest , large doses of alpha-adrenergic agonists that possess post-synaptic alpha-2 agonist properties , i.e . epinephrine and norepinephrine , may be required to enhance myocardial and cerebral hemodynamics . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
190,
201
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
206,
220
]
} |
b ) superoxide dismutase ( 10 mg/kg i.a . followed by 10 mg/kg i.v . over 1 h ) to scavenge the superoxide anion radical ; | NA | {
"id": "C0021966",
"name": "i",
"pos": [
11,
12
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
107,
112
]
} |
the test cells were normal balb/c 3t3 a31 cells , a squamous cell carcinoma from a human esophageal cancer ( kse-1 ) , human fetal fibroblasts , and v-79 cells from chinese hamster lung fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
9,
14
]
} | {
"id": "C0016030",
"name": "cells",
"pos": [
154,
159
]
} |
we conclude that the nonirradiated monolayer of balb/c 3t3 cells completely inhibits the growth of superinoculated normal balb/c 3t3 and human fetal fibroblasts , while on the other hand , they facilitate the growth of neoplastic kse-1 and v-79 cells by providing a surface for cell adherence and growth , without affecting the presence of normal cells in co-cultures . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
149,
160
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
347,
352
]
} |
pth was a reliable and sensitive test to establish the diagnosis of pshp , and that the urinary camp was useful for the diagnosis of secondary hyperparathyroidism in patients with jejunoileal bypass , but could not confirm the high nosographic sensitivity for the diagnosis of primary hyperparathyroidism . | NA | {
"id": "C0020503",
"name": "secondary hyperparathyroidism",
"pos": [
133,
162
]
} | {
"id": "C0020502",
"name": "hyperparathyroidism",
"pos": [
285,
304
]
} |
furthermore , down-regulation of pkc by pretreatment with the active phorbol esters pdb ( 24 h ) or pma ( 2 h ) , but not with the inactive phorbolester pdd , simultaneously inhibits killing by lak cells . | NA | {
"id": "C0039654",
"name": "pma",
"pos": [
100,
103
]
} | {
"id": "C0031586",
"name": "phorbolester",
"pos": [
140,
152
]
} |
we also demonstrate that pretreatment of target cells with phorbol ester ( pma ) decreases killing , suggesting that pkc activation in the target cell population may also influence killing although the effect may vary depending on the particular target cell used . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
59,
72
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
75,
78
]
} |
one patient presented with the classic features of systemic sclerosis , and the other with calcinosis , raynaud 's phenomenon oesophageal dysfunction , sclerodactyly , and telangiectasia ( crest syndrome ) . | NA | {
"id": "C0006663",
"name": "calcinosis",
"pos": [
91,
101
]
} | {
"id": "C0206138",
"name": "crest syndrome",
"pos": [
189,
203
]
} |
demonstration of modified dna may be taken as evidence of the interaction of a genotoxic agent with dna , which is the basis for this review of dna adducts as markers of exposure in hazardous waste work . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
26,
29
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
144,
155
]
} |
indications for study included proximal injury in 59 , abnormal pulse examination in six , expanding hematoma in four , neurologic abnormality in six and bleeding and hypotension in three . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
101,
109
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
154,
162
]
} |
arterial abnormalities were documented in 11 of these injuries , including five of injuries with an abnormal pulse , two with bleeding and hypotension , two with an expanding hematoma , one with a neurologic deficit and one of proximal injuries . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
126,
134
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
175,
183
]
} |
ten patients had adenoid cystic carcinomas , three patients squamous cell carcinomas , one patient a mucinous cell carcinoma , two patients a low grade adenocarcinoma and four patients low grade sarcomas . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
17,
42
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
152,
166
]
} |
the results show that adenoid cystic carcinomas , low grade adenocarcinomas and sarcomas benefit from neutron therapy . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
22,
47
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
60,
75
]
} |
seven of the pregnancies aborted spontaneously in the first trimester and one pregnancy was ectopic . | NA | {
"id": "C0032979",
"name": "first",
"pos": [
54,
59
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
78,
87
]
} |
lupus anticoagulant and antiphospholipid antibodies are associated with thromboembolic phenomena in individuals both with and without systemic lupus erythematosus . | NA | {
"id": "C0085240",
"name": "lupus anticoagulant",
"pos": [
0,
19
]
} | {
"id": "C0162595",
"name": "antiphospholipid antibodies",
"pos": [
24,
51
]
} |
to determine whether the apparent role of thy 1+ cells in the facilitation of bone marrow engraftment and induction of skin graft tolerance is related to alloaggression , the capacity of fully allogeneic c57bl/6j , h-2b bm cells to establish mixed lymphoid chimerism and skin graft tolerance in sublethally irradiated ( 2.5 gy x 3 ) balb/c , h-2d hosts was compared with that of semi-allogeneic balb/c x c57bl/6j f1 h-2d/b bm cells which genetically lack the potential for graft-versus-host reactivity against parental recipients . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
384,
394
]
} |
the levels of mixed chimerism observed with allogeneic and semi-allogeneic f1 bm cells were nearly identical : 21.0 +/- 9.7 % of spleen cells in h-2b bm-injected and 18.6 +/- 8.8 % of spleen cells in h-2d/b bm-injected h-2d hosts were of donor allotype . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
44,
54
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
191,
196
]
} |
there was no significant change in the urinary excretion rate for 6-keto-prostaglandin f1a or prostaglandin e during cyclosporine infusion . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
73,
86
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
94,
109
]
} |
previous studies have not reported the response of ldl cholesterol to dietary treatment , and it is this form of cholesterol that is most closely related to cardiovascular disease . | NA | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
51,
66
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
113,
124
]
} |
both animals were also shown to suffer from classical chronic obstructive pulmonary disease , i.e. , obstructive pulmonary disease in the presence of hay and , or , straw . | NA | {
"id": "C0024117",
"name": "chronic obstructive pulmonary disease",
"pos": [
54,
91
]
} | {
"id": "C0600260",
"name": "obstructive pulmonary disease",
"pos": [
101,
130
]
} |
tetrathionate , sulfate , dithionite , methionine , hydroxocobalamin , ascorbate , pyridoxal phosphate , alpha-ketoglutarate , alpha-ketobutyrate , gsh , gsh disulfide ( gssg ) and selenite were similar in efficacy to thiosulfate ( p less than 0.05 ; pr values 1.35-1.59 ) . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
16,
23
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
218,
229
]
} |
tetrathionate , sulfate , dithionite , methionine , hydroxocobalamin , ascorbate , pyridoxal phosphate , alpha-ketoglutarate , alpha-ketobutyrate , gsh , gsh disulfide ( gssg ) and selenite were similar in efficacy to thiosulfate ( p less than 0.05 ; pr values 1.35-1.59 ) . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
148,
151
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
170,
174
]
} |
the data obtained for bases ( purines and pyrimidines ) were calculated as nucleic-acid equivalents ( rna or dna ) ; | NA | {
"id": "C0028606",
"name": "nucleic-acid",
"pos": [
75,
87
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
109,
112
]
} |
also contents of the same heavy metals , except mercury , have been determined in 205 samples of 7 species of domestic vegetables ( lettuce , spinach , endive , beetroots , onions , celeriac and swedish turnips ) . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
26,
38
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
48,
55
]
} |
we found that an anti-lyt-1.2 monoclonal antibody that recognizes solely an epitope on certain t cells can crossreact with a shared epitope on both cell types . | NA | {
"id": "C0282580",
"name": "epitope",
"pos": [
76,
83
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
132,
139
]
} |
the lesions and features developed during phases of stress and during the attacks were associated with an increase in the plasma concentrations of noradrenalin , adrenalin and prolactin . | NA | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
147,
159
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
162,
171
]
} |
the adherent layer that forms in human bone marrow suspension cultures contains fibroblast colonies which arise from colony-forming cells ( cfu-f ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
80,
90
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} |
the exact place of the omega-3 fatty acids from fish and fish oil remains to be defined . | NA | {
"id": "C0015689",
"name": "omega-3 fatty acids",
"pos": [
23,
42
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
57,
65
]
} |
the pathogenesis of celiac disease appears to require interaction between a number of factors both intrinsic ( genetic susceptibility , activation of the immune system ) and extrinsic ( gluten susceptibility , activation of the immune system ) and extrinsic ( gluten and possibly other environmental factors ) . | NA | {
"id": "C0314657",
"name": "genetic",
"pos": [
111,
118
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
193,
207
]
} |
in 13 patients , the gm2 gangliosidoses , sandhoff disease and tay-sachs disease , were found to be constantly associated with homogeneously and symmetrically increased ct attenuation within the thalami . | NA | {
"id": "C0268274",
"name": "gm2 gangliosidoses",
"pos": [
21,
39
]
} | {
"id": "C0036161",
"name": "sandhoff disease",
"pos": [
42,
58
]
} |
in 13 patients , the gm2 gangliosidoses , sandhoff disease and tay-sachs disease , were found to be constantly associated with homogeneously and symmetrically increased ct attenuation within the thalami . | NA | {
"id": "C0268274",
"name": "gm2 gangliosidoses",
"pos": [
21,
39
]
} | {
"id": "C0039373",
"name": "tay-sachs disease",
"pos": [
63,
80
]
} |
we studied two cases of brain arteriovenous malformations ( avms ) , one sigmoid-transverse sinus dural avm , and one brain arteriovenous fistula ( avf ) . | NA | {
"id": "C0007772",
"name": "of brain arteriovenous malformations",
"pos": [
21,
57
]
} | {
"id": "C0003857",
"name": "avm",
"pos": [
104,
107
]
} |
we studied two cases of brain arteriovenous malformations ( avms ) , one sigmoid-transverse sinus dural avm , and one brain arteriovenous fistula ( avf ) . | NA | {
"id": "C0003857",
"name": "avm",
"pos": [
60,
63
]
} | {
"id": "C0003855",
"name": "arteriovenous fistula",
"pos": [
124,
145
]
} |
in order to provide a detailed description of the mr appearance of intracranial ependymoma , the mr examinations of 12 patients ( 10 with ependymomas and two with subependymomas ) were reviewed and correlated with operative and pathologic reports . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
138,
149
]
} | {
"id": "C0206725",
"name": "subependymomas",
"pos": [
163,
177
]
} |
solid ependymomas and subependymomas were iso- to hypointense relative to normal white matter on t1-weighted images and hyperintense on proton-density- and t2-weighted images . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
6,
17
]
} | {
"id": "C0206725",
"name": "subependymomas",
"pos": [
22,
36
]
} |
we conclude that the mr differentiation of ependymomas and subependymomas from other gliomas is provided most reliably by the location and morphology of the tumor and not by differences in signal intensity . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
43,
54
]
} | {
"id": "C0206725",
"name": "subependymomas",
"pos": [
59,
73
]
} |
we conclude that the mr differentiation of ependymomas and subependymomas from other gliomas is provided most reliably by the location and morphology of the tumor and not by differences in signal intensity . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
43,
54
]
} | {
"id": "C0017638",
"name": "gliomas",
"pos": [
85,
92
]
} |
indications for emergent or early coronary angiography and possible angioplasty are generally limited to ongoing infarction and/or recurrent ischemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
113,
123
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
141,
149
]
} |
according to the type of angina , the prevalence of significant coronary stenosis was 53 % for patients with angina at rest , 68 % for those with effort angina , and 92 % for those with mixed angina . | NA | {
"id": "C0002965",
"name": "angina at rest",
"pos": [
109,
123
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
192,
198
]
} |
this study prospectively assessed the electrophysiologic effects of parenteral magnesium sulfate administration on paroxysmal atrioventricular ( av ) reentrant supraventricular tachycardia and the efficacy of magnesium to terminate these arrhythmias . | NA | {
"id": "C0024480",
"name": "magnesium sulfate",
"pos": [
79,
96
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
209,
218
]
} |
all patients had a history of sustained supraventricular tachycardia requiring pharmacologic therapy or electrical cardioversion for termination of tachycardia . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
40,
68
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
148,
159
]
} |
after baseline electrophysiologic study , including documentation of sustained supraventricular tachycardia that was reproducibly induced , parenteral magnesium sulfate ( a bolus of 0.3 meq/kg of elemental magnesium infused over a 10-minute period followed by a maintenance infusion of 0.2 meq/kg/hr ) was administered during sustained supraventricular tachycardia . | NA | {
"id": "C0024480",
"name": "magnesium sulfate",
"pos": [
151,
168
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
206,
215
]
} |
the effects of intravenous adenosine and adenosine triphosphate ( atp ) were studied in a double-blind randomized study during 68 episodes of supraventricular tachycardia in 39 patients . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
27,
36
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
41,
63
]
} |
in patients receiving both compounds , the effective dosage of adenosine was 3.8 mg and of atp it was 6.6 mg ( p less than 0.05 ) , suggesting molar equipotency . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
63,
72
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
91,
94
]
} |
transient side effects were common , occurring in 81 % of episodes with adenosine and in 94 % with atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
72,
81
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
99,
102
]
} |
symptom scores ( 0 to 10 ) were not significantly different ( median score for adenosine was 5 , for atp it was 6 ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
79,
88
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
101,
104
]
} |
adenosine and atp were equally effective for the diagnosis and treatment of supraventricular tachycardias and the incidence and severity of side effects were similar . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
14,
17
]
} |
in this study , 30 american society of anesthesiologists class i and ii patients who did not have cardiac surgery and subsequently developed postoperative hypertension were randomly assigned to receive either nicardipine , a new dihydropyridine calcium channel blocker , or placebo . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
209,
220
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium channel blocker",
"pos": [
229,
268
]
} |
we have applied the espvr to the assessment of the inotropic effect of the new dihydropyridine calcium channel blocker , nicardipine , in 15 patients with heart failure caused by systolic dysfunction . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium channel blocker",
"pos": [
79,
118
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
121,
132
]
} |
nicardipine and nifedipine are structurally similar dihydropyridine calcium channel blockers with demonstrated efficacy in the treatment of stable angina pectoris . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
0,
11
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
52,
75
]
} |
nicardipine and nifedipine are structurally similar dihydropyridine calcium channel blockers with demonstrated efficacy in the treatment of stable angina pectoris . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
16,
26
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
52,
75
]
} |
two impinger methods ( the chromotropic acid method and modified pararosaniline method ) and the draeger short-term detector tube method ( with and without activation tubes ) were compared when sampling for formaldehyde from a particle board box , formalin solution , and a conventional home . | NA | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
207,
219
]
} | {
"id": "C0949307",
"name": "formalin",
"pos": [
248,
256
]
} |
absorption of 4,4'-methylenebis ( 2-chloroaniline ) ( mboca ) was assessed for five workers over one week in a polyurethane elastomer factory by measuring urinary mboca levels by high performance liquid chromatography ( hplc ) using an electrochemical detector . | NA | {
"id": "C0032616",
"name": "polyurethane",
"pos": [
111,
123
]
} | {
"id": "C0013766",
"name": "elastomer",
"pos": [
124,
133
]
} |
programmed stimulation always induced svt and was the only method capable of tachycardia induction in 14 patients . | NA | {
"id": "C0039240",
"name": "svt",
"pos": [
38,
41
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
77,
88
]
} |
both hcg and its alpha-subunit have been demonstrated in malignant pancreatic endocrine tumors by immunohistochemistry . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
5,
8
]
} | {
"id": "C0017963",
"name": "alpha-subunit",
"pos": [
17,
30
]
} |
when patients were separated by gender , control teeth in males exhibited a statistically significant increase in resorption over control teeth in females . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
32,
38
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
149,
154
]
} |
the concentration of alcohol in an alcoholic beverage apparently did not affect risk : beer carried a substantial risk , whereas less-dilute forms of alcohol carried no risk . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
87,
91
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
150,
157
]
} |
the associations of serum lipid and lipoprotein levels with the risk of cancer mortality were assessed in 2,753 men and 2,476 women aged 40-79 years at baseline ( 1972-1976 ) who participated in the lipid research clinics program mortality follow-up study through 1984 . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
36,
47
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
199,
204
]
} |
anemia recurred 6 months later despite continued therapy , and the patient was noted to have prca , which was treated successfully with two courses of high-dose bolus methylprednisolone therapy . | NA | {
"id": "C0002871",
"name": "anemia",
"pos": [
0,
6
]
} | {
"id": "C0034902",
"name": "prca",
"pos": [
93,
97
]
} |
ten patients had neutropenia , six of whom had severe neutropenia ( less than 500 neutrophils ) , including two with agranulocytosis . | NA | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
17,
28
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
117,
132
]
} |
neurofibromatosis 2 or bilateral acoustic neurofibromatosis ( nf2 ) is a severe autosomal dominant disorder characterized by the development of multiple tumors of the nervous system , including meningiomas , gliomas , neurofibromas , ependymomas , and particularly acoustic neuromas . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
208,
215
]
} | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
234,
245
]
} |
to obtain more definitive evidence , cell hybrids were derived from the fusion of mouse cells , deficient in hypoxanthine phosphoribosyltransferase , and fibroblasts of the seven xx males . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
37,
41
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
154,
165
]
} |
purpose : an increased incidence of thrombosis has been reported in patients with a prolonged activated partial thromboplastin time ( aptt ) due to a lupus anticoagulant ( la ) , which is an antibody to negatively charged phospholipids . | NA | {
"id": "C0085240",
"name": "lupus",
"pos": [
150,
155
]
} | {
"id": "C0162595",
"name": "antibody",
"pos": [
191,
199
]
} |
conclusion : liver biopsy , when indicated , is useful to detect opportunistic infection in hiv-infected patients who are not known to have aids . | NA | {
"id": "C0019693",
"name": "infection",
"pos": [
79,
88
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
140,
144
]
} |
after membrane lipid extraction , phospholipid mass , class composition , and fatty acid profiles were measured in each group . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
6,
20
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
34,
46
]
} |
to investigate the heterogeneity of congenital malformations , we analyzed the distribution of 14 selected anomalies among 11,421 children with isolated defects and with different patterns of multiple congenital anomalies ( mca ) . | NA | {
"id": "C0000768",
"name": "congenital malformations",
"pos": [
36,
60
]
} | {
"id": "C0000772",
"name": "multiple congenital anomalies",
"pos": [
192,
221
]
} |
aberrant bronchi should be considered when children with cardiac defects or multiple anomalies such as the vacterl association have unexplained respiratory symptoms and surgeons planning to treat such bronchial abnormalities should be aware of the high frequency of abnormal vessels in these cases . | NA | {
"id": "C0000772",
"name": "multiple anomalies",
"pos": [
76,
94
]
} | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
211,
224
]
} |
this was mainly because of a reduction of the branched chain amino acids valine , leucine , and isoleucine , and of lysine and serine . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
46,
72
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
73,
79
]
} |
this was mainly because of a reduction of the branched chain amino acids valine , leucine , and isoleucine , and of lysine and serine . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
46,
72
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
99,
106
]
} |
this was mainly because of a reduction of the branched chain amino acids valine , leucine , and isoleucine , and of lysine and serine . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
46,
72
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
96,
106
]
} |
effects and interactions of epinephrine , norepinephrine , timolol , and betaxolol on outflow facility in the cynomolgus monkey . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
28,
39
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} |
a single 5.5-micrograms intracameral dose of epinephrine or norepinephrine increased facility by 65 % to 70 % three to four hours after dosing . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
45,
56
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
and the facility-increasing effect of both epinephrine and norepinephrine is mediated by beta 2-adrenergic receptors in the trabecular endothelium . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
59,
73
]
} |
the binding was linear with protein in the range of 200-800 nm and in the presence of 3 % albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
28,
35
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
90,
97
]
} |
in addition , other glycosaminoglycans were not found to be inhibitory , and the inhibitory effects of heparin were discovered to be limited to vascular smooth muscle cells . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
20,
38
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
103,
110
]
} |
these cells in primary culture also respond to beta-adrenergic agonists in order of potency isoproterenol greater than epinephrine greater than norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
144,
158
]
} |
because approximately 85 % of total rna is rrna , these values indicated much more rapid formation of ribosomes in the lvfw than rvfw . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
36,
39
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
43,
47
]
} |
rats trained on a diurnal controlled meal-feeding schedule and injected with a single dose of 3,5,3'-triiodothyronine ( t3 ) failed to accumulate liver glycogen and incorporated less d- [ 6-3h ] glucose into glycogen than normally observed during the feeding period . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
146,
160
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
208,
216
]
} |
infusion of isoproterenol and epinephrine , but not of norepinephrine , acutely increased mnl beta-ar density , and this was blocked by the beta 2-selective antagonist ici 118,551 but not by the beta 1-selective antagonist bisoprolol , suggesting a beta 2-ar-mediated effect . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
55,
69
]
} |
the vasopressin antagonist , [ d ( ch2 ) 5avp ] ( manning compound , mc ) , the ang ii antagonist , saralasin ( sar ) , and the ganglionic blocking drug , hexamethonium ( hx ) , were injected in a random sequence into the left atrium ( la ) while bp and heart rate ( hr ) were monitored . | NA | {
"id": "C0003009",
"name": "ang ii",
"pos": [
80,
86
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
100,
109
]
} |
we conclude that web 2086 ameliorated endotoxin-induced lung injury without reducing oxidative stress in the rat and suggest that blockade of platelet-activating factor receptor may be an important therapeutic consideration in sepsis-induced acute lung vascular injury . | NA | {
"id": "C0273115",
"name": "lung injury",
"pos": [
56,
67
]
} | {
"id": "C0242488",
"name": "acute lung",
"pos": [
242,
252
]
} |
basal inositol phosphate accumulation and basal incorporation of myo- [ 3h ] inositol into aortic cell membranes from shrsp was not significantly different from wky values . | NA | {
"id": "C0021554",
"name": "inositol",
"pos": [
6,
14
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
77,
85
]
} |
significant depressions in na ( + ) -k ( + ) -adenosinetriphosphatase ( atpase ) activity and na ( + ) -ca2+ exchange were observed in the diabetic preparations in comparison to control . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
27,
29
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
72,
78
]
} |
the augmented release of epinephrine in rats maintained on the low-sodium diet appeared to depend on circulating angiotensin ii because blockade of angiotensin ii receptors with saralasin decreased the epinephrine release in these animals but not in rats maintained on the normal diet . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
113,
127
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
178,
187
]
} |
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