text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it rats had a lower weight and a lower change in weight from base line throughout most of the study . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
20,
26
]
} | {
"id": "C0005911",
"name": "change in weight",
"pos": [
39,
55
]
} |
electron-microscopic studies performed on eight cases showed glandular and squamous differentiation in one adenosquamous carcinoma , squamous differentiation in five squamous carcinomas , and neuroendocrine differentiation in one small-cell carcinoma . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
175,
185
]
} | {
"id": "C0262584",
"name": "neuroendocrine",
"pos": [
192,
206
]
} |
to investigate the etiology of chronic diarrhea associated with human immunodeficiency virus ( hiv ) infection in lusaka , we studied 63 hiv-positive patients and 36 seronegative controls clinically and endoscopically . | NA | {
"id": "C0019693",
"name": "human",
"pos": [
64,
69
]
} | {
"id": "C0019699",
"name": "hiv-positive",
"pos": [
137,
149
]
} |
use of metronidazole can reduce complications related to c. difficile , particularly if additional antimicrobials other than aminoglycosides are avoided . | NA | {
"id": "C1136254",
"name": "antimicrobials",
"pos": [
99,
113
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
125,
140
]
} |
following neck injuries , the changes in the anterior and middle scalene muscles are compatible with trauma , suggesting that fibrotic scalene muscles are an important cause of symptoms in traumatic tos . | NA | {
"id": "C0027531",
"name": "neck injuries",
"pos": [
10,
23
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
189,
195
]
} |
cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine , a new amide local anesthetic . | NA | {
"id": "C0006400",
"name": "bupivacaine",
"pos": [
41,
52
]
} | {
"id": "C2917349",
"name": "amide local anesthetic",
"pos": [
110,
132
]
} |
cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine , a new amide local anesthetic . | NA | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
57,
66
]
} | {
"id": "C2917349",
"name": "amide local anesthetic",
"pos": [
110,
132
]
} |
ropivacaine is a new amino-amide local anesthetic whose anesthetic profile appears similar to that of bupivacaine . | NA | {
"id": "C2917349",
"name": "amide local anesthetic",
"pos": [
27,
49
]
} | {
"id": "C0006400",
"name": "bupivacaine",
"pos": [
102,
113
]
} |
cells from infected cows bound less nla than did cells from healthy cows when assays were conducted with intact blood mononuclear cell preparations ( monocytes plus lymphocytes ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C1321301",
"name": "blood mononuclear cell",
"pos": [
112,
134
]
} |
norepinephrine ( ne ) and epinephrine ( epi ) collected from dogs were sequentially and temporally measured in blood and plasma at 24 c . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
26,
37
]
} |
in heparinized plasma , ne and epi concentrations were relatively stable in the absence or presence of preservative after 24 hours at 24 c . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
24,
26
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
31,
34
]
} |
in edta plasma , ne and epi values were less stable when compared with those in heparinized samples . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
17,
19
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
24,
27
]
} |
addition of preservative had no stabilizing effect on ne or epi in heparinized or edta plasma . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
54,
56
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
60,
63
]
} |
during long-term storage at -70 c , plasma ne and epi values decreased less than 0.6 and less than 0.1 pg/d , respectively . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
43,
45
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
50,
53
]
} |
norepinephrine and epi values were stable in heparinized blood for 6 hours but decreased to less than 25 % and less than 6 % of initial base line values , respectively , when plasma separation was delayed 24 hours . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
19,
22
]
} |
plasma protein extravasation ( ppe ) was induced in sprague-dawley rats by intratracheal infusion of capsaicin or by intratracheal infusion of mouse serum albumin-dinitrophenol ( msa-dnp ) after passive sensitization with ige-anti-dnp . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
163,
176
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
231,
234
]
} |
histamine responsiveness was assessed by calculating the provocation concentration of histamine diphosphate to increase lung resistance ( rl ) to 150 % ( pc 150 % rl ) , or decrease dynamic lung compliance ( cdyn ) to 75 % ( pc 75 % cdyn ) of the response to saline [ rl ( sal ) and cdyn ( sal ) , respectively ] . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
0,
9
]
} | {
"id": "C0062740",
"name": "histamine diphosphate",
"pos": [
86,
107
]
} |
group 3 comprised genetically epilepsy-resistant rats ( gerrs ) who received audiogenic stimulations but had no seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
30,
38
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
112,
120
]
} |
these observations support the hypothesis that dynorphin contributes to certain pathophysiological changes after traumatic spinal cord injury through both opiate-receptor ( kappa-receptor ) -mediated and nonopioid mechanisms . | NA | {
"id": "C0034801",
"name": "opiate-receptor",
"pos": [
155,
170
]
} | {
"id": "C0064239",
"name": "kappa-receptor",
"pos": [
173,
187
]
} |
to assess the role of endogenous opioids in the pathogenesis of apnea in children , the effect of oral treatment with the opioid antagonist naltrexone was studied in apneic infants , as well as in older apneic children , with demonstrated increases in csf immunoreactive beta-endorphin ( i-be ) . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
73,
81
]
} | {
"id": "C1455726",
"name": "older",
"pos": [
197,
202
]
} |
the demographics and course of patients with squamous cell carcinoma were different from either those of bowen 's disease or basal cell carcinoma in these population-based data . | NA | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
45,
68
]
} | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
105,
121
]
} |
initial treatment included digoxin ( effective in seven of 14 patients , with overdose in three ) , verapamil ( effective in three of three but fatal in one ) , cardioversion ( effective in all 10 who were treated in this way ) , iced water applied to the face ( effective in all 16 patients on 53 of 59 occasions , 90 % ) . | NA | {
"id": "C0020746",
"name": "iced",
"pos": [
230,
234
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
235,
240
]
} |
iced water is safe and effective , and should become the treatment of choice for termination of supraventricular tachycardia in neonates and young infants . | NA | {
"id": "C0020746",
"name": "iced",
"pos": [
0,
4
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
5,
10
]
} |
we report here the short-term treatment outcome of a 12-week comparison trial of bulimic outpatients who were randomly assigned to one of four treatment cells : ( 1 ) imipramine hydrochloride treatment , ( 2 ) placebo treatment , ( 3 ) imipramine treatment combined with intensive group psychotherapy , and ( 4 ) placebo treatment combined with intensive group psychotherapy . | NA | {
"id": "C0589978",
"name": "imipramine hydrochloride",
"pos": [
167,
191
]
} | {
"id": "C0020934",
"name": "imipramine",
"pos": [
236,
246
]
} |
in this paper , the cancer pain literature is briefly reviewed and evidence is presented for various psychological determinants of the pain report and response that may be extended to pain associated with cancer . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
20,
31
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
184,
188
]
} |
the structural events taking place during the reaction between pai-1 ( plasminogen-activator inhibitor 1 ) and the plasminogen activators sc-tpa ( single-chain tissue plasminogen activator ) and tc-tpa ( two-chain tissue plasminogen activator ) were studied . | NA | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
115,
137
]
} | {
"id": "C0032143",
"name": "tissue",
"pos": [
214,
220
]
} |
as a group , the enzymes could be distinguished from the class c beta-lactamases on the basis of the kappa cat . values for several substrates , particularly oxacillin , cloxacillin and carbenicillin . | NA | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
158,
167
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
170,
181
]
} |
for several cephalosporin substrates ( e.g . cefuroxime and cefotaxime ) class a enzymes consistently exhibited higher kappa cat . values than class c enzymes , thus belying the usual distinction between 'penicillinases ' and 'cephalosporinases ' . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
45,
55
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
60,
70
]
} |
antibody inhibition experiments were therefore carried out in liver microsomes using polyclonal anti- ( p-450 3 ) antibodies which cross-react with p-450 rlm2 , and using a monoclonal antibody that is reactive with and inhibitory towards p-450 3 but not p-450 rlm2 . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
114,
124
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
173,
192
]
} |
six structural analogues of this compound were synthesized and tested for their ability to inhibit alpha-l-fucosidase and other human liver glycosidases . | NA | {
"id": "C0016787",
"name": "alpha-l-fucosidase",
"pos": [
99,
117
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
140,
152
]
} |
the principal secreted proteoglycans are the previously described large chondroitin sulphate proteoglycan ( pg-l ) and the small dermatan sulphate proteoglycans ( pg-s1 and pg-s2 ) . | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
23,
36
]
} | {
"id": "C0033689",
"name": "chondroitin sulphate proteoglycan",
"pos": [
72,
105
]
} |
the principal secreted proteoglycans are the previously described large chondroitin sulphate proteoglycan ( pg-l ) and the small dermatan sulphate proteoglycans ( pg-s1 and pg-s2 ) . | NA | {
"id": "C0033689",
"name": "chondroitin sulphate proteoglycan",
"pos": [
72,
105
]
} | {
"id": "C0053574",
"name": "pg-s1",
"pos": [
163,
168
]
} |
a novel preparative method for the isolation of avidin and riboflavin-binding glycoprotein from chicken egg-white by the use of high-performance liquid chromatography . | NA | {
"id": "C0004434",
"name": "avidin",
"pos": [
48,
54
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
78,
90
]
} |
digestion of [ methionine-35s ] proteoglycans with chondroitinase and/or heparitinase , followed by sds/polyacrylamide-gel electrophoresis , indicated that the medium and cell layer contain at least three chondroitin sulphate proteoglycans , one dermatan sulphate proteoglycan , and two heparan sulphate proteoglycans which differ from one another in the size of core molecules . | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
32,
45
]
} | {
"id": "C0033689",
"name": "chondroitin sulphate proteoglycans",
"pos": [
205,
239
]
} |
the charge differences between the isoforms were due in part to differential h3 ( 32 ) po4 incorporation by the protein . | NA | {
"id": "C0597298",
"name": "isoforms",
"pos": [
35,
43
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
112,
119
]
} |
the liver preparation had a vmax . of 1.2 nmol of cyclic cmp formed/min per mg , and a km of 220 microm-ctp , and although active in the absence of added cations , it was stimulated by fe2+ and mn2+ ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
154,
161
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
199,
203
]
} |
angiotensin ii-stimulated inositol phosphates formation was inhibited by the angiotensin receptor antagonist [ sar-leu8 ] angiotensin ii , indicating that the above response was mediated through activation of an angiotensin receptor in intact glomeruli . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
0,
14
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
212,
223
]
} |
a high degree of homology is observed with lh/hcg receptor suggesting the definition of a new subfamily of g-protein coupled receptors . | NA | {
"id": "C0034823",
"name": "hcg receptor",
"pos": [
46,
58
]
} | {
"id": "C0682972",
"name": "g-protein coupled receptors",
"pos": [
107,
134
]
} |
hydrogen peroxide , an ubiquitous biologically occurring peroxide , was found to stimulate the dioxygenase activity of soybean lipoxygenase at the physiologically attainable concentration . | NA | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
0,
17
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
57,
65
]
} |
cell level studies of 3h-galactosylceramide ( galcer ) and 3h-galactosyl sphingosine ( galsph ) have been carried out in cultured skin fibroblasts from human and murine globoid cell leukodystrophy ( gld ) . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
135,
146
]
} |
the effects of three forms of endothelin ( et ) , et-1 , -2 and -3 , on intracellular free ca2+ concentration ( [ ca2+ ] i ) and their receptor binding activities have been compared in murine fibroblast cell line swiss 3t3 as well as diploid human fibroblast cell line fs-4 . | NA | {
"id": "C0079284",
"name": "endothelin",
"pos": [
30,
40
]
} | {
"id": "C0079281",
"name": "et-1",
"pos": [
50,
54
]
} |
the antigenic epitopes shared by these four proteins are limited to cysteine-rich or disultide bridge-masked domains . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
4,
13
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
14,
22
]
} |
in cells prelabeled with 3h-myo-inositol , amf stimulated a 200 % increase in total inositol phosphates ( inositol monophosphate , insp1 ; inositol bisphosphate , insp2 ; inositol trisphosphate , insp3 ) after 90 minutes of exposure , with a 300 % maximal increase in insp3 at 120 minutes . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
84,
103
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
171,
179
]
} |
in cells prelabeled with 3h-myo-inositol , amf stimulated a 200 % increase in total inositol phosphates ( inositol monophosphate , insp1 ; inositol bisphosphate , insp2 ; inositol trisphosphate , insp3 ) after 90 minutes of exposure , with a 300 % maximal increase in insp3 at 120 minutes . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
84,
103
]
} | {
"id": "C0021549",
"name": "insp3",
"pos": [
268,
273
]
} |
data suggest that the radioimmunoassay of plasma using antibodies recognizing prohormone sequences 1-30 and 31-67 may represent the measurement of a unique larger amino-terminal peptide fragment containing antigenic sites recognized by both antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
55,
65
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
241,
249
]
} |
the amino acid composition of calf apo-ai displayed an overall similarity to that of its human and other mammalian counterparts ( baboon , dog , badger , rabbit , rat and mouse ) , but differed in having higher proportions of glutamic acid , alanine and isoleucine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
242,
249
]
} |
however , residues 2 , 7 , 20 and 22 in calf ai ( i.e . aspartic acid , serine , glutamic acid and isoleucine , respectively ) were substituted by glutamic acid , proline or glutamine , aspartic acid , and valine or leucine respectively , in the other mammals . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
81,
89
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
174,
183
]
} |
calsequestrin , an intracellular calcium-binding protein of skeletal muscle sarcoplasmic reticulum , is homologous to aspartactin , a putative laminin-binding protein of the extracellular matrix . | NA | {
"id": "C0006787",
"name": "calsequestrin",
"pos": [
0,
13
]
} | {
"id": "C0006732",
"name": "calcium-binding protein",
"pos": [
33,
56
]
} |
experiments were undertaken to examine the effects of reduced ( gsh ) and oxidized ( gssg ) glutathione on lipid peroxidation of rat liver microsomes . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
85,
89
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
92,
103
]
} |
however , when gsh ( 5 mm ) and gssg ( 2.5 mm ) were combined in the assay system , inhibition of lipid peroxidation was enhanced markedly over that with gsh alone in microsomes containing alpha-tocopherol . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
32,
36
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
154,
157
]
} |
surprisingly , the synergistic inhibitory effect of gsh and gssg was also observed for microsomes that were deficient in alpha-tocopherol . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
52,
55
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
60,
64
]
} |
aroclor 1254 stimulated total hepatic cytochrome p-450 3.7-fold , and markedly increased the rate of sim metabolism and plasma elimination as determined by both hplc and ria techniques . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
105,
115
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
127,
138
]
} |
only one immunogenic species was present in the antigen preparation , but some antibodies that were cross-reactive to sites on catalase were present in the antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
79,
89
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
156,
165
]
} |
several organophosphates including diisopropylfluorophosphonate ( dpf ) and a variety of compounds used as chemical warfare agents produced dose- and time-dependent increases in phosphorylase-a , the phosphorylated form of glycogen phosphorylase in rat pheochromocytoma cells , pc12 , and isolated hepatocytes . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
178,
191
]
} | {
"id": "C0917785",
"name": "glycogen",
"pos": [
223,
231
]
} |
the release of endogenous epinephrine and norepinephrine from the vascular adrenergic neurons by periarterial nerve stimulation was examined in spontaneously hypertensive rats ( shr ) and age-matched wistar-kyoto rats ( wky ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
26,
37
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} |
the isolated mesenteric vasculatures were prepared , and the epinephrine and norepinephrine release during electrical nerve stimulation was determined as the increase in epinephrine and norepinephrine contents in the vascular perfusate . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
186,
200
]
} |
these results suggest that epinephrine could be released from the vascular adrenergic neurons as a cotransmitter of norepinephrine and contribute to increased vascular tone in hypertension . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
27,
38
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
116,
130
]
} |
sera from healthy individuals and from patients with infections caused by nonenteric bacteria contained low levels of mab-blocking antibodies . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
118,
121
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} |
adverse reactions appear to be more frequent and more serious with the use of nonselective alpha blockers than with selective alpha 1 blockers , such as terazosin or prazosin . | NA | {
"id": "C0076107",
"name": "terazosin",
"pos": [
153,
162
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
166,
174
]
} |
the calculations were carried out with a finite difference algorithm for solving the nonlinear poisson-boltzmann equation that incorporates the screening effects of the electrolyte , the exclusion of ions by the molecule , the molecular shape , and the different polarizabilities of the solvent and the trna . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
169,
180
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
200,
204
]
} |
these modifications include glycosylation , gamma-carboxylation and beta-hydroxylation of specific amino acids , and endoproteolytic processing to remove the pre- and propeptides and also to remove the pair of basic amino acids that connect the light and heavy chains in the precursor . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
99,
104
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
210,
227
]
} |
however , cell lines vary considerably in their capacity to remove the dibasic pair in the protein c precursor and , like the liver , secrete a mixed population of 1-chain and 2-chain forms of the protein . | NA | {
"id": "C0033665",
"name": "protein",
"pos": [
91,
98
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
197,
204
]
} |
we have demonstrated that the glutathione reaction can dramatically reduce the conformational stability of gamma-crystallins and , thus , that the thermodynamic quantities of the unreacted crystallins can be used to evaluate the stability of these proteins when modified during cataract formation . | NA | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
107,
124
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
189,
200
]
} |
we have addressed this question by investigating the permeability characteristics of channels formed by gramicidins where the nh2-terminal amino acid is either phenylalanine or one of a series of substituted phenylalanines : p-hydroxy- , p-methoxy- , o-fluoro- , m-fluoro- , or p-fluorophenylalanine . | NA | {
"id": "C0031453",
"name": "phenylalanines",
"pos": [
208,
222
]
} | {
"id": "C0030137",
"name": "p-fluorophenylalanine",
"pos": [
278,
299
]
} |
the compounds included doxorubicin , daunorubicin , two doxorubicin stereoisomers ( 4'-epimer and beta-anomer ) , and five chromophore-modified derivatives , with a wide range of cytotoxic activity and dna binding affinity . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
37,
49
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
56,
67
]
} |
this uncoupling effect of the fatty acids could be abolished by the addition of fatty acid-free bovine serum albumin ( bsa ) . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
30,
41
]
} | {
"id": "C0015688",
"name": "fatty acid-free",
"pos": [
80,
95
]
} |
time courses of transmembrane equilibration of 2-chloroadenosine , 2'-deoxyadenosine , 3'-deoxyadenosine , cytidine and 2'-deoxycytidine were measured by rapid kinetic techniques in human erythrocytes under equilibrium exchange and zero-trans conditions . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
107,
115
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
123,
136
]
} |
the six isoforms of the vdac protein were also observed in a non-equilibrium gel with 2 micrograms of the purified protein . | NA | {
"id": "C0597298",
"name": "isoforms",
"pos": [
8,
16
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
115,
122
]
} |
the serosal adrenoceptors mediating the na+ transport are more sensitive to norepinephrine ( ec50 = 1.2.10 ( -6 ) m ) than to epinephrine or isoproterenol . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
76,
90
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} |
the enzyme was stimulated by nh+4 ions and inhibited by palmitoyl , lauroyl , oleoyl , myristoyl and stearoyl-coa esters , glutamate and glucose 6-phosphate but not by acetyl-coa or shorter chain fatty acyl-coa esters . | NA | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
168,
178
]
} | {
"id": "C0001374",
"name": "fatty acyl-coa",
"pos": [
196,
210
]
} |
it is proposed that high levels of active metalloproteinases are released from neutrophils into septic synovial fluids and that these proteinases complex all the available timp , forming metalloproteinase-timp complexes . | NA | {
"id": "C0025543",
"name": "metalloproteinases",
"pos": [
42,
60
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
134,
145
]
} |
in contrast , in u937 cells , free fatty acids are incorporated into various substances rather than into cholesteryl esters ( as revealed by hplc analysis ) , so that the cholesterol in acldl taken up by u937 cells is not synthesized into cholesteryl esters to any great extent . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
171,
182
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
239,
257
]
} |
interaction between cell surface negative charges and protamine sulfate , stimulated the synthesis of prostaglandins e2 , f2 alpha , 6-keto-pgf1 alpha and thromboxane b2 ( txb2 ) in a dose-dependent manner , reaching a maximum response at protamine concentration of 50 micrograms/ml . | NA | {
"id": "C0033602",
"name": "protamine sulfate",
"pos": [
54,
71
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
239,
248
]
} |
in a first experiment with 24 newborn lambs , the promoting effect of colostrum feeding on the fresh weight of the small intestine and its protein content was demonstrated by comparison with that of other dietary treatments ( fasting , lactose , protein hydrolysate feeding ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
246,
265
]
} |
for both albumin and fibrinogen , the maximum effects of precoated proteins on platelet shape changes were observed when the surface protein concentration reached the monolayer concentration . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
9,
16
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
67,
75
]
} |
for both albumin and fibrinogen , the maximum effects of precoated proteins on platelet shape changes were observed when the surface protein concentration reached the monolayer concentration . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
67,
75
]
} | {
"id": "C0025252",
"name": "surface protein",
"pos": [
125,
140
]
} |
activated high molecular weight hageman factor ( 75 kd ) and hageman factor carboxy-terminal fragments both formed complexes with purified c1 ( - ) -inhibitor , but the hageman factor fragments appeared to have a higher affinity for the c1 ( - ) -inhibitor than activated hageman factor . | NA | {
"id": "C0015525",
"name": "hageman factor",
"pos": [
32,
46
]
} | {
"id": "C0015527",
"name": "activated hageman factor",
"pos": [
262,
286
]
} |
therefore , the clot-promoting activity of activated hageman factor might be relatively unimpaired if hageman factor fragments are also present . | NA | {
"id": "C0015527",
"name": "activated hageman factor",
"pos": [
43,
67
]
} | {
"id": "C0015525",
"name": "hageman",
"pos": [
102,
109
]
} |
patients with cardiomyopathy , myocarditis , valvular heart disease , myocardial infarction or cardiac surgery in the previous two weeks or with left bundle branch block and women of childbearing age were excluded . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
14,
28
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
31,
42
]
} |
objective : to determine whether pituitary suppression before induction of ovulation reduces the rate of spontaneous abortion in women with polycystic ovarian disease and primary recurrent spontaneous abortions . | NA | {
"id": "C0000786",
"name": "spontaneous abortion",
"pos": [
105,
125
]
} | {
"id": "C0000809",
"name": "recurrent spontaneous abortions",
"pos": [
179,
210
]
} |
conclusion : pituitary suppression before induction of ovulation significantly reduces the risk of spontaneous abortion in women with polycystic ovarian disease and primary recurrent spontaneous abortions . | NA | {
"id": "C0000786",
"name": "spontaneous abortion",
"pos": [
99,
119
]
} | {
"id": "C0000809",
"name": "recurrent spontaneous",
"pos": [
173,
194
]
} |
in association with the rectal anomaly , three of them had a presacral tumour ( teratoma in two , hamartoma in one ) and all had a deformed sacrum . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
71,
77
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
98,
107
]
} |
endoscopic sphincterotomy is now the first choice treatment for surgical complications of hepatic hydatid disease open to the biliary tree , as well as the drainage procedure of choice in patients with cholangitis due to hydatid disease . | NA | {
"id": "C0013504",
"name": "hepatic hydatid disease",
"pos": [
90,
113
]
} | {
"id": "C0013502",
"name": "hydatid disease",
"pos": [
221,
236
]
} |
by contrast , incubation of bovine caudate membranes with 10 ( -4 ) m gtpgammas , a non-hydrolyzable analog of gtp , results in a decrease in both the apparent affinity ( kd ) and density ( bmax ) of 5-ht1d binding sites . | NA | {
"id": "C0079469",
"name": "gtpgammas",
"pos": [
70,
79
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
111,
114
]
} |
plasma epinephrine and norepinephrine were measured radioenzymatically in rats with intact adrenals or adrenalectomy , and with or without infusion of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
23,
37
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
151,
162
]
} |
dmrf stimulation induced widespread increases in rcbf associated with a 50-fold increase in plasma epinephrine and a 20-fold increase in norepinephrine without changes in the electroencephalogram . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
99,
110
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
137,
151
]
} |
substance p and neurokinin a , two coexisting tachykinins stimulating the release of [ 3h ] 5-ht from rat cerebral cortical slices . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
0,
11
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
46,
57
]
} |
substance p and neurokinin a , two coexisting tachykinins stimulating the release of [ 3h ] 5-ht from rat cerebral cortical slices . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
16,
28
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
46,
57
]
} |
substance p ( sp ) and neurokinin a ( nka ) , two coexisting neuropeptides of the tachykinin family , stimulated the basal ( 5 mm k+ ) and evoked ( 40 mm k+ ) release of [ 3h ] 5-ht ( 5-hydroxytryptamine ) from tissue slices of the rat cerebral cortex . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
0,
11
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
82,
92
]
} |
substance p ( sp ) and neurokinin a ( nka ) , two coexisting neuropeptides of the tachykinin family , stimulated the basal ( 5 mm k+ ) and evoked ( 40 mm k+ ) release of [ 3h ] 5-ht ( 5-hydroxytryptamine ) from tissue slices of the rat cerebral cortex . | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
23,
35
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
82,
92
]
} |
among these proteins , p70 evoked epileptic discharges on the electroencorticograph and behavioral seizure , when it was intracortically injected into the motor region of the normal rat cerebrum . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
34,
43
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
99,
106
]
} |
to investigate the effect of advances in the prevention and treatment of pulmonary embolism , we examined the rates of death from pulmonary embolism in canada for 1965-87 and compared them with those for the united states for 1962-84 . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
83,
91
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
130,
148
]
} |
ki-67 scores were significantly higher in the dna aneuploid than in the dna diploid tumors . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} | {
"id": "C0012930",
"name": "dna",
"pos": [
72,
75
]
} |
this translocation was confined to the tumor and not been previously reported either in nephroblastoma or any other neoplastic processes . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
39,
44
]
} | {
"id": "C0027671",
"name": "neoplastic",
"pos": [
116,
126
]
} |
the highest level of covalent binding of bp to liver dna ( 188 fmol bp adducts/mg dna ) was observed 25-30 days following treatment . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
53,
56
]
} | {
"id": "C0242958",
"name": "adducts",
"pos": [
71,
78
]
} |
this work on formulation , tolerated doses in vivo , and localized peritumoral effects of cb now permits evaluation of systemic antitumor effects of cytochalasin b as a single agent . | NA | {
"id": "C0010737",
"name": "cb",
"pos": [
90,
92
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
149,
161
]
} |
the frequent finding of t-pa ( alone or in combination with u-pa ) suggests that t-pa can also be a tumor-associated plasminogen activator . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
24,
28
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
117,
138
]
} |
in 11 of the 22 cells pai-1 mrna and in 6 of the 22 cells pai-2 mrna was found , pointing to a possible role of plasminogen activator inhibitors in the tumor-related plasminogen activator activity . | NA | {
"id": "C0030190",
"name": "pai-1",
"pos": [
22,
27
]
} | {
"id": "C0032145",
"name": "plasminogen activator",
"pos": [
166,
187
]
} |
in 11 of the 22 cells pai-1 mrna and in 6 of the 22 cells pai-2 mrna was found , pointing to a possible role of plasminogen activator inhibitors in the tumor-related plasminogen activator activity . | NA | {
"id": "C0030191",
"name": "pai-2",
"pos": [
58,
63
]
} | {
"id": "C0032145",
"name": "plasminogen activator",
"pos": [
166,
187
]
} |
in contrast to the biphasic effects observed for the er mrna , the level of the regulatory subunit type ii beta of the camp-dependent protein kinase ( protein kinase a ) was enhanced in a concentration-dependent manner by human chorionic gonadotropin . | NA | {
"id": "C0033639",
"name": "type ii",
"pos": [
99,
106
]
} | {
"id": "C0010531",
"name": "protein",
"pos": [
151,
158
]
} |
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