text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
inhibition by cks-17 conjugates was selective in that il-2 production was inhibited to a greater degree than general protein synthesis in el4 cells , and general protein synthesis by fibroblasts was unaffected . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
183,
194
]
} |
this gene rearrangement was detected in all of the transfectants and in all of the original tumor dnas , but not in normal dna of the same patients , thus indicating that this genetic lesion occurred in vivo and is specific to somatic tumors . | NA | {
"id": "C0012930",
"name": "tumor dnas",
"pos": [
92,
102
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
123,
126
]
} |
analysis of pnh erythrocytes after treatment with terminal complement proteins shows that the h19-negative erythrocytes are more susceptible to c5b-9-mediated lysis . | NA | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
59,
78
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
144,
149
]
} |
the present work demonstrates that antibody-induced cross-linking of mhc class i antigens on jurkat t lymphoma cells leads to a rise in intracellular calcium ( cai2+ ) and , in the presence of phorbol ester ( pma ) , to il-2 production and il-2 receptor expression . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
193,
206
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
209,
212
]
} |
to elucidate the second messenger ( s ) of il-4 action in mature b cells , we performed blocking experiments with inhibitors of various aspects of cellular responses , using ia-inducing activity of il-4 as a readout system . | NA | {
"id": "C0021758",
"name": "il-4",
"pos": [
43,
47
]
} | {
"id": "C0021764",
"name": "il-4",
"pos": [
198,
202
]
} |
the effect of recombinant ( r ) interleukin-1 beta ( ril-1 beta ) and transforming growth factor-beta ( tgf-beta ) on the production of interleukin-2 ( il-2 ) and interleukin-6 ( il-6 ) from an antigen-specific ( lbrm-33-1a5 ) and an antigen-nonspecific ( el-4-nob-1 ) t-cell line was investigated . | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
32,
43
]
} | {
"id": "C0021760",
"name": "interleukin-6",
"pos": [
163,
176
]
} |
here we show that recombinant murine il-2 , il-6 , and ifn-gamma each differentially regulate the il-4/pma-driven growth of thymocyte subpopulations . | NA | {
"id": "C0021760",
"name": "il-6",
"pos": [
44,
48
]
} | {
"id": "C0021764",
"name": "il",
"pos": [
98,
100
]
} |
the number and volume percentage occupied by ahf were determined by quantitative stereologic methods on serial frozen sections stained for the markers gamma-glutamyltranspeptidase ( ggt ) , canalicular adenosine triphosphatase ( atpase ) , glucose-6-phosphatase ( g6pase ) and the placental form of glutathione s-transferase ( gst-pi ) . | NA | {
"id": "C0017837",
"name": "glutathione s-transferase",
"pos": [
299,
324
]
} | {
"id": "C0537086",
"name": "gst-pi",
"pos": [
327,
333
]
} |
the levels of glutathione s-transferase ( gst ) isoenzymes , gst pi , b1 , b2 and mu were measured , by radioimmunoassay , in human bronchoalveolar lavage fluid from a series of patients presenting with neoplastic ( n = 12 ) and non-neoplastic lung diseases ( n = 10 ) . | NA | {
"id": "C0017837",
"name": "glutathione s-transferase",
"pos": [
14,
39
]
} | {
"id": "C0537086",
"name": "gst pi",
"pos": [
61,
67
]
} |
the findings of the radioimmunoassay , of greater levels of gst b1 and b2 than gst pi in lavage fluid , were confirmed by a one-step purification of gst from lung lavage , using affinity chromatography , followed by their identification using sds-polyacrylamide gel . | NA | {
"id": "C0537086",
"name": "gst pi",
"pos": [
79,
85
]
} | {
"id": "C0017837",
"name": "gst",
"pos": [
149,
152
]
} |
studies of the membrane lipid profile provide evidence that endotoxin administration modifies the molecular structure of cardiac membrane lipids in association with the activation of phospholipases a1 and a2 and with the inhibition of phospholipid methylating enzymes . | NA | {
"id": "C0025249",
"name": "structure",
"pos": [
108,
117
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
235,
247
]
} |
lipoprotein ( a ) [ lp ( a ) ] is a low-density lipoprotein ( ldl ) -like lipoprotein particle recently described as a risk factor for premature coronary heart disease , stroke , and atherosclerosis . | NA | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
20,
26
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
74,
85
]
} |
variation in concentration of lipids , lipoprotein lipids , and apolipoproteins a-i and b in plasma from healthy women . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
39,
50
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
51,
57
]
} |
the components of total variation -- biological , inter- and intra-individual , and analytical -- of plasma lipids , lipoprotein lipids , and apolipoproteins a-i and b have been determined in a population of 44 healthy women , ages 18-35 years . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
117,
128
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
129,
135
]
} |
preliminary elisa screening of 247 serum samples from patients with various inflammatory disorders indicated that the concentration of a specific epitope ( s ) on alpha 1-antitrypsin recognized by this monoclonal antibody was increased significantly in patients with active systemic lupus erythematosus , mixed connective tissue disease , and rheumatoid arthritis , but not in patients with sclerodermic disorders or sjogren 's syndrome . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
343,
363
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
417,
436
]
} |
samples are treated for 10 min with nonlimiting amounts of bilirubin oxidase to form biliverdin from bilirubin before the reagent for cholesterol is added . | NA | {
"id": "C0005446",
"name": "biliverdin",
"pos": [
85,
95
]
} | {
"id": "C0005437",
"name": "bilirubin",
"pos": [
101,
110
]
} |
mice raised on the maize-based ( gluten-free ) diet responded well to parenteral immunization with each of six gluten-derived protein preparations ( whole gliadin , two omega-gliadin fractions , wheat salt-soluble proteins , a peptic-tryptic digest and a subtilisin digest of gluten ) , as serum antibody levels increased at least 300-fold in each case . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
155,
162
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
276,
282
]
} |
in contrast , mice raised on the wheat-based diet responded poorly to immunization with either whole gliadin or omega-gliadin and were virtually non-responsive to enzymic digest of gluten . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
101,
108
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
181,
187
]
} |
eluted patient antibodies and rabbit antisera showed a linear fluorescence pattern on isolated hepatocytes from rat and rabbit . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
15,
25
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
37,
45
]
} |
cmc was significantly lower in an patients ( 4 +/- 2 versus 10 +/- 3 in controls , expressed as lytic units/10 ( 6 ) cells ; p less than 0.05 ) , but no difference could be found between an and controls in ifn activity as reflected by the level of the ifn-induced enzyme 2'-5 ' oligoadenylate synthetase ( 2-5a ) in pbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
117,
122
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
316,
320
]
} |
rheumatoid factors ( rf ) have been shown to have considerable heterogeneity and bind with igg as well as with a variety of substances such as nuclear histone , non-histone nuclear protein , nitrophenyl groups or ssdna . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
151,
158
]
} | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
173,
188
]
} |
when subunit vaccine ( sv ) of either influenza a or influenza b virus was added to in vitro splenocyte cultures stimulated with wvv , the eia antibody response to homologous wvv was reduced . | NA | {
"id": "C0887892",
"name": "subunit",
"pos": [
5,
12
]
} | {
"id": "C0042210",
"name": "wvv",
"pos": [
175,
178
]
} |
it was found to be effected only by sv of strains of the same virus subtype -- when svs prepared from a heterotypic ( h3n2 ) strain , an h1n1 strain and an influenza b strain were added to splenocyte cultures in the presence of wvv . | NA | {
"id": "C0887892",
"name": "sv",
"pos": [
36,
38
]
} | {
"id": "C0042210",
"name": "wvv",
"pos": [
228,
231
]
} |
when splenocytes from immunologically naive mice , exposed in vitro to sv , were transferred to secondary cultures of primed splenocytes , the antibody response to wvv in the secondary cultures was also reduced . | NA | {
"id": "C0887892",
"name": "sv",
"pos": [
71,
73
]
} | {
"id": "C0042210",
"name": "wvv",
"pos": [
164,
167
]
} |
we report here the results of such an attempt to immortalize antibody-forming cells from spleen of an autoimmune thrombocytopenic purpura ( atp ) patient and characterize the resulting mab . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
61,
69
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
185,
188
]
} |
using immunofluorescence analyses of permeabilized and fixed cell lines and tissues , the 4g9 mab was shown to be anti-vimentin specific by virtue of its intracellular staining pattern , decoration of cell lines of mesenchymal ( but not epithelial ) origin , and by the fact that polyclonal anti-vimentin ( and not anti-actin , prekeratin , tubulin or vinculin ) antibodies inhibited its binding to intermediate filaments of a fibroblastoid cell line . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
94,
97
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
363,
373
]
} |
contact dermatitis caused by intermediate products in the manufacture of clenbuterol , ranitidine base , and ranitidine hydrochloride . | NA | {
"id": "C0034665",
"name": "ranitidine",
"pos": [
87,
97
]
} | {
"id": "C0700466",
"name": "ranitidine hydrochloride",
"pos": [
109,
133
]
} |
chloracne is a rare but important acneiform eruption often associated with the ingestion of chlorinated phenolic agents such as dioxins with subsequent toxicity from these chemicals . | NA | {
"id": "C0263454",
"name": "chloracne",
"pos": [
0,
9
]
} | {
"id": "C0175167",
"name": "acneiform eruption",
"pos": [
34,
52
]
} |
osteoblastic and chondroblastic ( i.e. , osteogenic ) cells belong to the stromal cell system , which is associated with bone marrow , and bone and is separate from the hematopoietic stem-cell system . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
54,
59
]
} | {
"id": "C0018956",
"name": "hematopoietic stem-cell",
"pos": [
169,
192
]
} |
marrow-derived osteogenic cells are a component of marrow stroma , which in vitro form fibroblastic-type colonies . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
87,
99
]
} |
experimental investigations support the possibility of neoplastic induction by heavy metals , particularly cobalt , cadmium , and nickel . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
79,
91
]
} | {
"id": "C0009148",
"name": "cobalt",
"pos": [
107,
113
]
} |
experimental investigations support the possibility of neoplastic induction by heavy metals , particularly cobalt , cadmium , and nickel . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
79,
91
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
116,
123
]
} |
experimental investigations support the possibility of neoplastic induction by heavy metals , particularly cobalt , cadmium , and nickel . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
79,
91
]
} | {
"id": "C0028013",
"name": "nickel",
"pos": [
130,
136
]
} |
the role of degenerative changes of the menisci , including tears of the horizontal type , in the development of osteoarthritis ( oa ) of the knee is a subject of intense interest , as is the relationship between chondrocalcinosis and oa . | NA | {
"id": "C0409959",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0029408",
"name": "oa",
"pos": [
235,
237
]
} |
oral antimicrobial agents -- notably ampicillin , amoxicillin , amoxicillin-clavulanate , cefaclor , cefuroxime axetil , bacampicillin , cyclacillin , erythromycin ethylsuccinate-sulfisoxazole , cefixime , and trimethoprim-sulfamethoxazole -- are the mainstay of treatment . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
37,
47
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
64,
75
]
} |
stimulation of renin release by dihydralazine increases the da/na ratio in arterial and renal venous blood indicating release of 'precursor dopamine ' from noradrenergic fibres and/or activation of dopaminergic nerves . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
140,
148
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
198,
210
]
} |
these data suggest that the gallstone matrix may inhibit stone dissolution even after stone fragmentation . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
28,
37
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
86,
91
]
} |
stimulation of secretory iga and secretory component of immunoglobulins in small intestine of rats treated with saccharomyces boulardii . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
15,
28
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
33,
52
]
} |
to study the mechanisms of the protective effect of s.b . against enteral pathogen infection , we assessed the response of the intestinal secretion of secretory iga ( s-iga ) and of the secretory component of immunoglobulins ( sc ) to oral administration of high doses ( 0.5 mg/g body weight , three times per day ) of s.b . cells in growing rats . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
151,
164
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
186,
205
]
} |
chemotherapy consisted of actinomycin d and vincristine , adriamycin was added for stages iii-v and cyclophosphamide or ifosfamide for histologically highly malignant variants . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
100,
116
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
120,
130
]
} |
a semi-structured interview was developed for classification of seizures in accordance with the 1981 international league against epilepsy ( ilae ) criteria . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
64,
72
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
130,
138
]
} |
interview-based diagnoses for 50 patients were compared with independent diagnoses by neurologists who also use the ilae system for seizure classification . | NA | {
"id": "C0014544",
"name": "ilae",
"pos": [
116,
120
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
132,
139
]
} |
the dihydropyridine calcium antagonists nimodipine ( nmd ) , pn200-110 , and nicardipine were compared with phenytoin ( pht ) as potential anticonvulsants in electrocortical shock ( ecs ) -induced seizures in the white new zealand rabbit . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
4,
39
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
40,
50
]
} |
the dihydropyridine calcium antagonists nimodipine ( nmd ) , pn200-110 , and nicardipine were compared with phenytoin ( pht ) as potential anticonvulsants in electrocortical shock ( ecs ) -induced seizures in the white new zealand rabbit . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
4,
39
]
} | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
77,
88
]
} |
the major outcome measures used were a 50-item true-false test specifically designed to evaluate the see program , the washington psychosocial seizure inventory , the beck depression inventory , lubin 's depression adjective checklist , the state-trait anxiety inventory , the acceptance of disability scale , and sherer 's self-efficacy scale . | NA | {
"id": "C0014544",
"name": "see",
"pos": [
101,
104
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
143,
150
]
} |
the treatment group demonstrated a significant increase in overall understanding of epilepsy , a significant decrease in fear of seizures , and a significant decrease in hazardous medical self-management practices . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
84,
92
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
129,
137
]
} |
by means of a questionnaire , we analyzed leisure time habits of 44 adult in-patients with active epilepsy ( i.e. , at least one seizure a month for the last year ) . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
98,
106
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
129,
136
]
} |
effect of physical training on aerobic capacity , seizure occurrence , and serum level of antiepileptic drugs in adults with epilepsy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
50,
57
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
125,
133
]
} |
the mitochondrial gene t-urf13 from maize ( zea mays l. ) with texas male-sterile ( t ) cytoplasm codes for a unique 13 kd polypeptide , t-urf13 , which is implicated in cytoplasmic male sterility and sensitivity to the insecticide methomyl and to host-specific fungal toxins produced by helminthosporium maydis race t ( hmt toxin ) and phyllosticta maydis ( pm toxin ) . | NA | {
"id": "C0026955",
"name": "fungal toxins",
"pos": [
262,
275
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
362,
367
]
} |
immunoblot analysis and ptx adp-ribosylation of the purified light sarcoplasmic reticulum ( lsr ) , heavy sarcoplasmic reticulum ( hsr ) and t-tubule subcellular fractions indicate the discrete presence of g proteins in lsr , an unambiguous labelling of the hsr fraction , while t-tubule membranes clearly appear very rich in a go-like protein , confirming the observed preferential immunocytochemical distribution of g protein subunits . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
208,
215
]
} | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
420,
436
]
} |
cd4 , the t cell surface antigen , is phosphorylated and internalized when t cells are activated or treated with a phorbol ester , pma . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
115,
128
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
131,
134
]
} |
two classes of immunoglobulin , igm and igd , are present as antigen receptors on the surface of mature b lymphocytes . | NA | {
"id": "C0021017",
"name": "classes",
"pos": [
4,
11
]
} | {
"id": "C0020843",
"name": "igd",
"pos": [
40,
43
]
} |
the steady-state concentration of the rna component of rnase p is also reduced in the mutant , whereas the amount of u3 rna , 7sl rna , trna , rrna and mrna are the same as wild-type . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
143,
147
]
} |
the exercise-induced increases of the pro-opiomelanocortin ( pomc ) -derived peptides , acth , beta-ep , and beta-lph , were highly correlated with each other ( p values less than 0.001 ) , and were correlated with prolactin increases , ( p values less than 0.05 ) . | NA | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
38,
58
]
} | {
"id": "C0023832",
"name": "beta-lph",
"pos": [
109,
117
]
} |
for exercise at wa , a steady state was attained for vo2 , [ lactate ] and ph both pre- and post-training , despite blood [ norepinephrine ] and [ epinephrine ] ( [ ne ] , [ e ] ) and rectal temperature continuing to rise . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
124,
138
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
147,
158
]
} |
using a disc diffusion and an agar dilution method the susceptibility was determined of 100 isolates to ampicillin , chloramphenicol , erythromycin , rifampicin , amoxicillin/clavulanic acid , gentamicin , cefaclor , cefotaxime , tetracycline , sulphamethoxazole , trimethoprim and trimethoprim/sulphamethoxazole ( 1:19 ) . | NA | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
245,
262
]
} | {
"id": "C0041044",
"name": "trimethoprim/sulphamethoxazole",
"pos": [
282,
312
]
} |
the in vitro activity of dirithromycin ( ly-237216 ) , a new macrolide erythromycin derivative , was compared to that of four other agents ( clarithromycin , erythromycin , roxithromycin , clindamycin ) against 334 gram-positive isolates obtained from cancer patients . | NA | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
141,
155
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
158,
170
]
} |
the in vitro activity of dirithromycin ( ly-237216 ) , a new macrolide erythromycin derivative , was compared to that of four other agents ( clarithromycin , erythromycin , roxithromycin , clindamycin ) against 334 gram-positive isolates obtained from cancer patients . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
71,
83
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
173,
186
]
} |
in vivo and in vitro effects of porphyrins ( tin-protoporphyrin [ snpp ] , cobalt-mesoporphyrin , haemin and protoporphyrin ) on neonatal rats were investigated . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
32,
42
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
109,
123
]
} |
body weight ( y in grams ) could be expressed as a function of birth weight ( a in grams ) and age ( x in weeks ) by the following equation : y = a + b x , where b indicates growth rate . | NA | {
"id": "C0005910",
"name": "body",
"pos": [
0,
4
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
63,
75
]
} |
addition of either antiserum against il-1 alpha or il-1 beta reduced the il-1 activity in cm , suggesting that aml blasts produce both il-1 alpha and il-1 beta . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
37,
41
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
135,
145
]
} |
adrenaline , noradrenaline , tyramine , n-methyldopamine , n-acetyldopamine , and 5-hydroxytryptamine , if present , were below the limits of detectability . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
administration of the lhrh agonist , nafarelin ( d- ( nal2 ) 6 gnrh ) , at a dosage of 200 micrograms twice daily intranasally in 13 patients with uterine leiomyomata resulted in a reduction in uterine volume to a mean of 55.1 % at 3 months and 44.5 % at 6 months as measured using ultrasound . | NA | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
37,
46
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
63,
67
]
} |
this stimulation was mimicked by addition of dibutyryl-cyclic amp , indicating that fsh action on the alpha-subunit gene is exerted via cyclic amp . | NA | {
"id": "C0012054",
"name": "dibutyryl-cyclic amp",
"pos": [
45,
65
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
136,
146
]
} |
neurite outgrowth promoting properties of neural cell surface proteins can be assessed by immobilizing isolated membrane proteins on nitrocellulose-coated petri dishes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
62,
70
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
112,
129
]
} |
the nucleotide and deduced amino acid sequence of a cdna clone of the chicken ngf receptor ( ngfr ) is reported and is compared with sequences of mammalian ngf receptors . | NA | {
"id": "C0254837",
"name": "ngf receptor",
"pos": [
78,
90
]
} | {
"id": "C0132173",
"name": "ngf",
"pos": [
156,
159
]
} |
the reading frame encoding the mitochondrial capsule seleno-protein ends with an amber stop codon suggesting that selenium is not incorporated cotranslationally into the protein by an opal suppressor selenocysteyl-trna as has been found for several eukaryotic and bacterial proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
60,
67
]
} | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
264,
282
]
} |
however , muscle insulin resistance was not improved in acarbose-treated obese mice at maximal and submaximal effective concentrations , despite a higher insulin binding in muscles of acarbose-treated obese than in control obese animals . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
17,
35
]
} | {
"id": "C0020459",
"name": "higher insulin",
"pos": [
147,
161
]
} |
proinsulin and c-peptide at onset and during 12 months cyclosporin treatment of type 1 ( insulin-dependent ) diabetes mellitus . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
15,
24
]
} |
we studied fasting proinsulin levels and proinsulin/c-peptide ratios in the newly diagnosed diabetic subjects participating in the canadian/european placebo controlled cyclosporin study at entry , during the one year treatment period and six months of follow-up . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
19,
29
]
} | {
"id": "C0006558",
"name": "proinsulin/c-peptide",
"pos": [
41,
61
]
} |
further , proinsulin and c-peptide were studied in 83 cyclosporin and 86 placebo-treated subjects during the trial and follow-up . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
10,
20
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
25,
34
]
} |
cell kinetic disturbances induced by treatment of human diploid fibroblasts with 5-azacytidine indicate a major role for dna methylation in the regulation of the chromosome cycle . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} |
polymorphic morphs revealed by the enzymes psti , ecorv , and hincii , can be unambiguously scored and make this centromeric region an excellent genetic marker for the study of multiple endocrine neoplasia , type 2a ( men2a ) , as well as for chromosome 10 linkage studies in general . | NA | {
"id": "C0027662",
"name": "multiple endocrine neoplasia",
"pos": [
177,
205
]
} | {
"id": "C0025268",
"name": "men2a",
"pos": [
218,
223
]
} |
human pepsinogen ( pga ) exhibits extensive polymorphism that can be detected both at the protein and the dna level . | NA | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
6,
16
]
} | {
"id": "C0077923",
"name": "pga",
"pos": [
19,
22
]
} |
tuberous sclerosis ( tsc ) is a dominantly inherited disorder characterized by hamartomas and hamartias in one or more organs , most often in skin , brain , and kidneys . | NA | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
0,
18
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
79,
89
]
} |
the tyrosinase probe tyr ( 11q14-11q22 ) gave a maximum lod score of 2.88 at theta = 0 . | NA | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
4,
14
]
} | {
"id": "C0041484",
"name": "tyr",
"pos": [
21,
24
]
} |
determination of the transcription initiation site by primer extension analysis of monocytic mrna indicated that our pai-2 cdna was , at most , only three nucleotides short of full length , yielding a primary pai-2 transcript with a 66-bp first exon . | NA | {
"id": "C0030191",
"name": "pai-2",
"pos": [
117,
122
]
} | {
"id": "C0032145",
"name": "pai-2",
"pos": [
209,
214
]
} |
although nf-kappa b can not be activated by lps , it can be activated by treatment with phorbol ester ( pma ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
88,
101
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
104,
107
]
} |
the forearm vasoconstrictor response to lower body negative pressure ( lbnp ) , a reflex stimulus to norepinephrine release , can be augmented by a prior brachial artery infusion of epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
182,
193
]
} |
although the precise function of the chromogranins remains elusive , knowledge of their structure , distribution , and potential intracellular and extracellular roles , especially that of chromogranin a , has greatly expanded during recent years . | NA | {
"id": "C0008586",
"name": "chromogranins",
"pos": [
37,
50
]
} | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
188,
202
]
} |
dna sequences of genes encoding allelic or isotypic dr or dq molecules that appear to express the same t-cell-defined epitopes were compared in an attempt to identify association of shared sequences with shared epitopes . | NA | {
"id": "C0282580",
"name": "t-cell",
"pos": [
103,
109
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
211,
219
]
} |
the effects that actinobacillus pleuropneumoniae bacterins containing paraffin ( mineral ) oil , al ( oh ) 3 , or lecithin-base oil adjuvants had on antibody production and muscle irritation were studied . | NA | {
"id": "C0030415",
"name": "paraffin",
"pos": [
70,
78
]
} | {
"id": "C0026156",
"name": "mineral",
"pos": [
81,
88
]
} |
whereas numerous congenital anomalies in south american camelids have been reported , multiple anomalies are uncommon . | NA | {
"id": "C0000768",
"name": "congenital anomalies",
"pos": [
17,
37
]
} | {
"id": "C0000772",
"name": "multiple anomalies",
"pos": [
86,
104
]
} |
the arg solution provided .50 g arg.hcl/kg bw and was equimolar with orn.hcl ( .40 g/kg ) . | NA | {
"id": "C0003765",
"name": "arg",
"pos": [
4,
7
]
} | {
"id": "C0301556",
"name": "arg.hcl",
"pos": [
32,
39
]
} |
lambs were housed in metabolism crates for excreta collection and received 729 g dm/d of a 13.7 % cp diet in equal portions four times daily . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
21,
31
]
} | {
"id": "C0221102",
"name": "excreta",
"pos": [
43,
50
]
} |
in-vitro activity of azithromycin , erythromycin , ciprofloxacin and norfloxacin against neisseria gonorrhoeae , haemophilus ducreyi , and chlamydia trachomatis . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
21,
33
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
36,
48
]
} |
the minimum inhibitory concentrations ( mics ) of azithromycin , erythromycin , ciprofloxacin and norfloxacin for 300 strains of neisseria gonorrhoeae , 100 strains of haemophilus ducreyi and six strains of chlamydia trachomatis were determined . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
50,
62
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
65,
77
]
} |
azithromycin was approximately eight-fold more active against n. gonorrhoeae than was erythromycin ( mic90 : 0.25 mg/l azithromycin , 2.0 mg/l erythromycin ) . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
0,
12
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
143,
155
]
} |
azithromycin had considerable activity against h. ducreyi and was ten-fold more active than was erythromycin ( mic90 : 0.004 mg/l azithromycin , 0.03 mg/l erythromycin ) . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
0,
12
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
155,
167
]
} |
azithromycin and erythromycin were compared for efficacy in guinea pigs infected with an aerosol containing legionella pneumophila . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
0,
12
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
17,
29
]
} |
azithromycin was also found to be superior to erythromycin in eliminating lung infectivity and reducing mortality , when administered orally . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
0,
12
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
46,
58
]
} |
two open , randomized , single centre studies have investigated the efficacy and safety of azithromycin ( cp-62,993 ) in the treatment of infections by azithromycin-sensitive pathogens : ( a ) acute bacterial infections of skin or soft tissue ( compared with erythromycin ; n = 82 ) ; | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
91,
103
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
259,
271
]
} |
in study a , 68 patients were clinically assessed : clinical cure or improvement in patients receiving azithromycin or erythromycin was achieved in 86 % and 82 % , respectively . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
103,
115
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
119,
131
]
} |
side effects were observed in one of 57 patients on azithromycin and in six of 44 patients on erythromycin . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
52,
64
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
94,
106
]
} |
the mics of azithromycin , erythromycin and roxithromycin were determined ( by an agar dilution method ) for 65 strains of gram-negative bacteria responsible for endocarditis and gastrointestinal infections , for 20 strains of non-fermenting gram-negative bacteria and for 16 strains of anaerobic bacteria . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
12,
24
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
27,
39
]
} |
the mics of azithromycin , erythromycin and roxithromycin were determined ( by an agar dilution method ) for 65 strains of gram-negative bacteria responsible for endocarditis and gastrointestinal infections , for 20 strains of non-fermenting gram-negative bacteria and for 16 strains of anaerobic bacteria . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
27,
39
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
44,
57
]
} |
the mics of azithromycin were up to eight times lower than those of erythromycin and ( except in the case of flavobacterium spp . ) up to 16 times lower than those of roxithromycin . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
12,
24
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
68,
80
]
} |
the mics of azithromycin were up to eight times lower than those of erythromycin and ( except in the case of flavobacterium spp . ) up to 16 times lower than those of roxithromycin . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
68,
80
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
167,
180
]
} |
the in-vitro activities of azithromycin and erythromycin were compared against 689 clinical isolates , including gram-positive cocci , haemophilus influenzae , and anaerobes . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
27,
39
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
44,
56
]
} |
of the 100 methicillin-susceptible isolates of staphylococcus aureus tested , 77 % were susceptible to 1 mg/l azithromycin and 0.5 mg/l erythromycin , whereas 22 % were resistant to 32 mg/l of both compounds . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
110,
122
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
136,
148
]
} |
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