text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the partial embedding of the photopigment molecules in the lipid core introduces a correlation of the photopigment molecules with lipid hydrocarbon chains in the plane of the disk membranes . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
59,
64
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
130,
135
]
} |
neutral cannabinoids with a pentyl side chain-for example , cannabidiol , tetrahydrocannabinol , and cannabinol-are generally accompanied by homologs with a propyl side chain , of which at least one has psychotropic activity . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
8,
20
]
} | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
74,
94
]
} |
neutral cannabinoids with a pentyl side chain-for example , cannabidiol , tetrahydrocannabinol , and cannabinol-are generally accompanied by homologs with a propyl side chain , of which at least one has psychotropic activity . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
8,
20
]
} | {
"id": "C0006865",
"name": "cannabinol",
"pos": [
101,
111
]
} |
these studies compare the secretory pathways of newly formed rat serum glycoproteins and albumin by studying their submicrosomal localization at early times after the beginning of their synthesis and also by determining the submicrosomal site of incorporation of n-acetylglucosamine , mannose , galactose , and leucine into protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
89,
96
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
324,
331
]
} |
to determine whether the radio-active sugars were being incorporated into serum proteins or into membrane protein , the solubilized in vivo-labeled proteins were treated with specific antisera to rat serum proteins or to albumin . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
97,
113
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
206,
214
]
} |
to determine whether the radio-active sugars were being incorporated into serum proteins or into membrane protein , the solubilized in vivo-labeled proteins were treated with specific antisera to rat serum proteins or to albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
80,
88
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
221,
228
]
} |
immunoelectrophoresis of the ( 14 ) c-labeled leucine membrane and cisternal proteins showed that the membranes contained radioactive serum glycoprotein but no albumin , while the cisternal fraction contained all of the radioactive albumin and some glycoproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
77,
85
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
232,
239
]
} |
during s , only 20-25 % of the proteins synthesized and transported to the acidic residual chromosomal protein fraction are chased during the first 2 hr after pulse labeling , whereas up to 40 % of the material entering the residual nuclear fraction in mitosis , g ( 1 ) , and g ( 2 ) leaves during a 2 hr chase . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
31,
39
]
} | {
"id": "C0007292",
"name": "transported",
"pos": [
56,
67
]
} |
photometric results also show that much ( but not all ) of the spermatid nuclear protein loss is in somatic-type histone , as evidenced by a dramatic fall in the histone/dna ratio of these cells during a period in which nuclear dna content remains constant . | NA | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
73,
88
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
162,
169
]
} |
cells starving in the salt solution release in 5 hr about two-thirds of their beta-glucosidase , beta-n-acetylglucosaminidase , alpha-glucosidase , and amylase activities , about one-third of their deoxyribonuclease and phosphatase activities , smaller amounts of ribonuclease , and only a negligible fraction of their proteinase activity and protein content . | NA | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
83,
94
]
} | {
"id": "C0002272",
"name": "alpha-glucosidase",
"pos": [
128,
145
]
} |
the results suggest that cell surface antigens , such as histocompatibility antigens , may be of importance in the pathogenesis of several kinds of glomerulonephritis . | NA | {
"id": "C0003339",
"name": "cell surface",
"pos": [
25,
37
]
} | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
57,
84
]
} |
in each case the antibodies of the donor mouse reacted most effectively on a weight basis with antiidiotypic antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
17,
27
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
109,
118
]
} |
c57/bl and dba antisera contained very low concentrations of specificities present in the a/j and balb/c antibody populations ; | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
15,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
105,
113
]
} |
it did not appear to be present on hematopoietic precursor stem cells and was lost during differentiation to antibody-forming cells . | NA | {
"id": "C0018956",
"name": "hematopoietic",
"pos": [
35,
48
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
126,
131
]
} |
moreover , the demonstration of the increased avidity of receptors of antigen-binding lymphocytes , which appear to be precursors of antibody-synthesizing cells , strongly suggests that the antigen-driven selectional process operates primarily on this cell type . | NA | {
"id": "C0018956",
"name": "precursors",
"pos": [
119,
129
]
} | {
"id": "C0007634",
"name": "cell type",
"pos": [
252,
261
]
} |
precursors of antibody-forming cells were shown to be the cell population where the suppressive activity of anti-micro was mediated . | NA | {
"id": "C0018956",
"name": "precursors",
"pos": [
0,
10
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
58,
62
]
} |
it is not possible to determine from the data whether stimulation of precursor cells with gammag or gammaa receptors requires concommitant stimulation of separate cells with only gammam receptors , or whether cells bearing gammam receptors are precommitted to or differentiate into cells capable of synthesis of other ig classes , or whether receptors of gammam and another ig class are present on some virgin precursors or the second ig receptor appears after antigenic stimulation . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
69,
84
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
282,
287
]
} |
poliovirus type 1 shuts off incorporation of amino acids into vsv-specific proteins within 2 hr after superinfection of cells already committed to massive synthesis of vsv proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
75,
83
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
155,
164
]
} |
appreciable amounts of viral coat protein remain attached to ribosomes and polysomes during r17 bacteriophage replication , supporting the hypothesis of the repressor role of this protein . | NA | {
"id": "C0042736",
"name": "viral",
"pos": [
23,
28
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
180,
187
]
} |
s organism grows poorly on ethanol unless a hydrogen-utilizing methanogenic bacterium is included to utilize the h ( 2 ) produced during growth . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
44,
52
]
} | {
"id": "C0011744",
"name": "h ( 2",
"pos": [
113,
118
]
} |
of a variety of hexoses and carbon compounds examined , glucose , and to a lesser extent , mannose , proved to be the most repressive for enzyme synthesis . | NA | {
"id": "C0019494",
"name": "hexoses",
"pos": [
16,
23
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
91,
98
]
} |
( iv ) during glycerol deprivation , the free fatty acid content increased from 1.2 to 12.5 % of the total extractable fatty acids and then slowly decreased . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
41,
56
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
119,
130
]
} |
measurement of a parameter related to the rate of initiation of stable ( ribosomal and transfer ) rna chains showed that the initiation of transcription of these stable rna species was completely inhibited during the diauxie lag , but could be restored to the rate characteristic of log-phase cells by shift-up with glucose . | NA | {
"id": "C0035711",
"name": "transfer",
"pos": [
87,
95
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
169,
172
]
} |
sucrose gradient analysis of rna purified from cells after a glucose shift-up indicated an increased rate of accumulation of the ribosomal and transfer rna species . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
29,
32
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
143,
155
]
} |
fatty acid analysis of the phospholipids of each fraction revealed that the wall phospholipids contain a greater proportion of palmitic acid . | NA | {
"id": "C0771648",
"name": "of",
"pos": [
20,
22
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
81,
94
]
} |
the activation was presumed to result in the formation of an iron-enzyme complex , because once activated the enzyme retained essentially full activity in a reaction mixture not supplemented with iron or reducing agent . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
66,
80
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
110,
116
]
} |
the presence of pyridoxal phosphate as coenzyme was indicated by absorption maxima at 330 and 420 nm and fluorescence maxima at 390 and 520 nm . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
16,
35
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
39,
47
]
} |
the major amino sugars and amino acids in the peptidoglycan component were glucosamine , muramic acid , alanine , glutamic acid and diaminopimelic acid in the molar ratios 1.18:1.24:1.77:1.00:0.79 . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
27,
38
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
104,
111
]
} |
the excitability of short segments ( 5-7 mm ) of bundles of canine purkinje fibers was depressed by exposure to 15-18 mm k ( + ) , to 15-18 mm k ( + ) plus 5 x 10 ( -6 ) epinephrine or norepinephrine , to low k ( + ) , and to low na ( + ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
170,
181
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
185,
199
]
} |
severe thoracic dystrophy with striking micromelia , abnormal osseous development , including the spine , and multiple visceral anomalies . | NA | {
"id": "C0000768",
"name": "abnormal",
"pos": [
53,
61
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
110,
118
]
} |
the activity of ( na + k ) -adenosine triphosphatase ( atpase ) and the influx of k ( 42 ) and rb ( 86 ) into the red cells are high at birth and are reduced to 5 and 15 % of their original values , respectively , in mature animals . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
18,
20
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
55,
61
]
} |
indoleamine metabolism in affective disorders : excretion of tryptamine , indoleacetic acid and 5-hydroxy-indoleacetic acid in depressive states . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
12,
22
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
48,
57
]
} |
effect of ph on conversion of proinsulin to insulin by a subcellular fraction of rat islets . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
30,
40
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
44,
51
]
} |
rabbit antisera to rat lymphosarcoma contain antibodies that are cytolytic for rat erythrocytes in the presence of complement . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
45,
55
]
} |
the data suggest that cytolytic antibodies and agglutinating antibodies in these antisera are distinctive despite their common specificity for cytolipin r . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
32,
42
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
81,
89
]
} |
there was also a greater accumulation of esterified cholesterol in the liver than that produced by cholesterol alone , ethanol administration alone , or the summation of both effects . | NA | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
41,
63
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
99,
110
]
} |
amides resembling ceramide ( fatty acyl sphingosine ) were synthesized and tested for their effects on rat brain cerebrosidase ( galactosyl ceramide beta-galactosidase ) . | NA | {
"id": "C0002482",
"name": "amides",
"pos": [
0,
6
]
} | {
"id": "C0007745",
"name": "ceramide",
"pos": [
140,
148
]
} |
the preparation incorporated [ ( 3 ) h ] -lysine into the protein moieties of lipoproteins of d < 1.006 g/ml ( chylomicrons plus very low density ) which appeared in lymph and accounted for more than 30 % of all labeled lymph protein . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
78,
90
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
111,
123
]
} |
adrenaline or noradrenaline in single doses ( 0.01-0.10 mug/kg ) or by continuous infusion ( 0.3-3.0 mug.kg ( -1 ) min ( -1 ) ) into anaesthetized dogs has been administered by different routes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
14,
27
]
} |
the teratological effect of certain thiadiazoles related to acetazolamide , with a note on sulfanilamide and thiazide diuretics . | NA | {
"id": "C0039837",
"name": "thiadiazoles",
"pos": [
36,
48
]
} | {
"id": "C0000981",
"name": "acetazolamide",
"pos": [
60,
73
]
} |
intracisternal administration of [ ( 14 ) c ] tryptamine results in the formation of n-methyl-and dimethyltryptamine ( a psychotomimetic compound ) in the rat brain . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
46,
56
]
} | {
"id": "C0027183",
"name": "dimethyltryptamine",
"pos": [
98,
116
]
} |
an enzyme that converts tryptamine and n-methyl-tryptamine to n-methyl-and dimethyltryptamine was found to be present in rat and human brain . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
24,
34
]
} | {
"id": "C0027183",
"name": "dimethyltryptamine",
"pos": [
75,
93
]
} |
cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [ 1- ( 14 ) c ] galactose to ( 14 ) co ( 2 ) to the same extent as normal cells , but did so at a significantly slower rate . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
31,
42
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
171,
183
]
} |
antisera produced in four different species ( monkeys , rabbits , horses , hamsters ) and immune ascitic fluids prepared in mice were compared for suitability in fa staining . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "fa",
"pos": [
162,
164
]
} |
prophage induction in lysogenic escherichia coli w1709 ( iota ) was determined for 29 n-nitroso compounds , 13 of their denitrosated derivatives , and 7 hydroxylamino and hydrazino analogues of nitrosamines . | NA | {
"id": "C0028199",
"name": "nitroso compounds",
"pos": [
88,
105
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
194,
206
]
} |
simultaneous radioimmunoassay of plasma fsh , lh , progesterone , 17-hydroxyprogesterone , and estradiol-17 beta during the menstrual cycle . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
51,
63
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
66,
88
]
} |
the early rise of plasma growth hormone ( hgh ) and immunoreactive insulin ( iri ) in children following intravenous glucagon . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
25,
39
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
42,
45
]
} |
effects of phosphate and other anions on the reaction between ferrous ion and cytochrome c . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
11,
20
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
31,
37
]
} |
effects of phosphate and other anions on the reaction between ferrous ion and cytochrome c . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
31,
37
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
70,
73
]
} |
amino acid substitution in two identical inherited human serum albumin variants : albumin oliphant and albumin ann arbor . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
51,
70
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
103,
110
]
} |
model parameters for hemoglobin a and for hemoglobin chesapeake were determined from studies of the binding of spin-label triphosphates to ligand-free and partially liganded hemoglobin solutions , and to the hybrids alpha ( 2 ) ( +cn ) beta ( 2 ) and alpha ( 2 ) beta ( 2 ) ( +cn ) . | NA | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
21,
33
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
174,
184
]
} |
the closed-circular dna of buoyant density 1.701 g/cm ( 3 ) , and free of linear dna , is associated with the sole particulate band obtained on sucrose gradient centrifugation of a mitochondrial preparation from respiratory-deficient cells . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
11,
23
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
81,
84
]
} |
first , rna synthesized in vitro competes with the hybridization of [ ( 32 ) p ] rrna synthesized in vivo to the heavy strand of b. subtilis dna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
8,
11
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
81,
85
]
} |
second , unlabeled rrna synthesized in vivo competes with the hybridization of [ ( 3 ) h ] rna synthesized in vitro to denatured dna or heavy-strand dna , but not to light-strand dna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
19,
23
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
91,
94
]
} |
rna molecules purified by this selection procedure hybridized efficiently with both viral dna ( 24-50 % ) and dna from untransformed cells ( 12-27 % ) . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
84,
93
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
110,
113
]
} |
the high efficiency of hybridization with dna from untransformed cells implies that viral dna is integrated adjacent to highly reiterated cellular dna sequences . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
42,
45
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
84,
93
]
} |
molecular hybridization with radioactively labeled dna complementary to the rna of the rauscher leukemia virus was used to probe for homologous rna in the polysome fraction of human leukemic cells . | NA | {
"id": "C0056208",
"name": "complementary",
"pos": [
55,
68
]
} | {
"id": "C0035683",
"name": "probe",
"pos": [
123,
128
]
} |
we have hypothesized that hereditary spherocytosis , a congenital hemolytic anemia associated with intrinsically rigid and mishapen erythrocytes , might result from genetically defective microfilaments in erythrocyte membranes . | NA | {
"id": "C0037889",
"name": "hereditary spherocytosis",
"pos": [
26,
50
]
} | {
"id": "C0002881",
"name": "congenital",
"pos": [
55,
65
]
} |
the affinity of the e prostaglandins for this receptor preparation is greater than that of a and f prostaglandins , an observation consistent with their relative potencies in stimulating cyclic amp formation in isolated mouse ovaries and various other organs . | NA | {
"id": "C0033559",
"name": "e prostaglandins",
"pos": [
20,
36
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
99,
113
]
} |
the results suggest that ( i ) no antigenic relationship exists between terminal transferase and dna polymerase , ( ii ) common antigenic determinants exist in the dna polymerases from all mammalian sources , and ( iii ) multiple forms of dna polymerase found in mammalian , cells are related by having polypeptide sequences or subunits in common . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
34,
43
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
128,
150
]
} |
the cell types have been designated b cells [ precursors of plaque-forming cells ( pfc ) ] and t cells ( thymus-influenced cells , not providing precursors of detectable pfc ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
38,
43
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
145,
155
]
} |
this b cell response is fully restored to control levels by thymus cells from normal mice which do not themselves provide precursors of indirect pfc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
67,
72
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
122,
132
]
} |
the greatest quantity of mif was detected in supernatants of lymphocytes collected during s phase after the cells were synchronized in g ( 1 ) and in supernatants of growing fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
108,
113
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
this study , using horseradish peroxidase as a marker , confirms and extends our previous observations using fluorescent dye-labeled albumin that vascular permeability to proteins remains essentially intact during this phase , and becomes altered only when necrosis and hemorrhage supervene . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
133,
140
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
171,
179
]
} |
study of the morphologic and physiologic features of the biliary excretory apparatus at 24 and 48 hours after the induction of intrahepatic cholestasis by manganese-bilirubin overload shows that at the same time that physiologic cholestasis is rapidly waning , morphologic features of cholestasis are , in fact , increasing . | NA | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
127,
151
]
} | {
"id": "C0008370",
"name": "cholestasis",
"pos": [
285,
296
]
} |
role of atp in the intracellular translocation of proinsulin and insulin in the rat pancreatic b cell . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
50,
60
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
65,
72
]
} |
half of group 5 were given bovine origin antiserum containing antibodies against ibr , bvd and pi3 . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
41,
50
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
62,
72
]
} |
the effect of protein fractions from rabbit uterine fluids on embryo growth and uptake of nucleic acid and protein precursors . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0033665",
"name": "protein precursors",
"pos": [
107,
125
]
} |
differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
28,
43
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
80,
84
]
} |
the tissue distribution , metabolism and excretion of lidocaine in rats , guinea pigs , dogs and man . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
26,
36
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
41,
50
]
} |
the purified preparation of choline kinase had a sigmoid saturation curve with respect to choline , with a hill number of 2.3 , and was inhibited by adp ( competitive in nature and allosteric in binding , with a hill number of 2.7 ) and by phosphorylcholine ( non-competitive and non-allosteric ) . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
28,
35
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
240,
257
]
} |
the reversible interaction of zinc with pig insulin and proinsulin has been studied at ph7 by equilibrium dialysis ( ultrafiltration ) and by sedimentation equilibrium and velocity measurements in the ultracentrifuge . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
44,
51
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
56,
66
]
} |
binding values calculated from equilibria , where the ratio of free to bound zinc was varied in the range 0.01:1-10:1 , indicated that proinsulin and insulin each contained two main orders of zinc binding with very different affinities for the metal . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
135,
145
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
150,
157
]
} |
in equilibria containing low concentrations of free zinc ( free : bound ratios of 0.01-0.1:1 ) both insulin and proinsulin aggregated to form soluble hexamers containing firmly bound zinc ( up to 0.284g-atom/monomer ) with an apparent intrinsic association constant of 1.9x10 ( 6 ) m ( -1 ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
100,
107
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
112,
122
]
} |
higher concentrations of zinc ( free : bound ratios of 0.1-10.0:1 ) resulted in a progressive difference in the zinc binding , aggregation and solubility properties of the metal complexes of insulin and proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
191,
198
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
203,
213
]
} |
these results would indicate that the presence of the peptide segment connecting the insulin moiety in proinsulin does not prevent the firm binding of zinc to the insulin moiety and the formation of hexamers of zinc-proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
85,
92
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
216,
226
]
} |
at the same time although the connecting peptide contains additional sites of lower affinity for zinc , which should facilitate inter- and intra-molecular cross-linking , the general conformation of the zinc-proinsulin hexamer must preclude the formation of very large and close-packed aggregates that are insoluble in solutions at equilibrium . | NA | {
"id": "C0006558",
"name": "connecting peptide",
"pos": [
30,
48
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
208,
218
]
} |
[ identification of 2 new neurohypophyseal hormones , valitocin ( val 8 -oxytocin ) and aspartocin ( asn 4 -oxytocin ) in a selachian fish , the spiny dog-fish ( squalus acanthias ) ] . | NA | {
"id": "C0032017",
"name": "neurohypophyseal hormones",
"pos": [
26,
51
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
108,
116
]
} |
effects of epinephrine and norepinephrine on the hepatic lipids of the nurse shark , ginglymostoma cirratum . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
11,
22
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
27,
41
]
} |
( c ) rbw at normal plasma bicarbonate concentrations was the major cause of acidosis , and its magnitude was the major determinant of corrective alkali therapy ( 5-9 meq/kg per day ) , just as in the patient with fs , who was found to have type 2 ( `` '' proximal '' '' ) rta . | NA | {
"id": "C0001122",
"name": "acidosis",
"pos": [
77,
85
]
} | {
"id": "C0001126",
"name": ") r",
"pos": [
271,
274
]
} |
all strains of anaerobic coryneforms have some combination of galactose , glucose , or mannose as cell wall sugars , and most have alanine ( ala ) , glutamic acid ( glu ) , glycine ( gly ) , and l-alpha-epsilon-diaminopimelic acid ( l-dap ) as amino acids of peptidoglycan . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
131,
138
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
244,
255
]
} |
all strains of anaerobic coryneforms have some combination of galactose , glucose , or mannose as cell wall sugars , and most have alanine ( ala ) , glutamic acid ( glu ) , glycine ( gly ) , and l-alpha-epsilon-diaminopimelic acid ( l-dap ) as amino acids of peptidoglycan . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
173,
180
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
244,
255
]
} |
by hydrolysis in weak acid , the lps has been separated into a polysaccharide part ( degraded polysaccharide ) and a lipid part ( lipid a ) . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
33,
36
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
130,
137
]
} |
the dahp synthetase activity was inhibited solely by the aromatic amino acids , tyrosine , tryptophan , and phenylalanine , of the possible effectors tested . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
57,
77
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
80,
88
]
} |
the dahp synthetase activity was inhibited solely by the aromatic amino acids , tyrosine , tryptophan , and phenylalanine , of the possible effectors tested . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
57,
77
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
91,
101
]
} |
the dahp synthetase activity was inhibited solely by the aromatic amino acids , tyrosine , tryptophan , and phenylalanine , of the possible effectors tested . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
57,
77
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
108,
121
]
} |
from pulse-labeled cells , each fraction contained precursor rrna , and there was a 10s rna in the m fraction . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
61,
65
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis of ribosomal proteins of rhodopseudomonas palustris revealed that the 29s subunit lacked a high-molecular-weight protein . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
61,
79
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
171,
178
]
} |
[ experience in studying heat emission by the calorimetric method in patients with itching dermatoses treated with borderline bucky rays ] . | NA | {
"id": "C0033774",
"name": "itching",
"pos": [
83,
90
]
} | {
"id": "C0037274",
"name": "dermatoses",
"pos": [
91,
101
]
} |
picogram-sensitive assay for endotoxin : gelation of limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid a from gram-negative bacteria . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
29,
38
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
110,
129
]
} |
picogram-sensitive assay for endotoxin : gelation of limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid a from gram-negative bacteria . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
110,
129
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
134,
141
]
} |
dopamine is a more potent activator of the bovine enzyme than is norepinephrine or epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
83,
94
]
} |
fluorescence of quinacrine in the presence of different polynucleotides was studied to attempt to identify the specific nucleotides responsible for the fluorescence of stained chromosome preparations . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
56,
71
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
120,
131
]
} |
a hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
39,
52
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
229,
241
]
} |
a hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
56,
69
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
229,
241
]
} |
[ changes in the concentration of nucleic acids ( rna-dna ) in the myometrium of women during pregnancy and labor ] . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
34,
47
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
54,
57
]
} |
modulation of in vitro lymphocyte transformation by antibodies : enhancement by antigen-antibody complexes and inhibition by antibody excess . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
52,
62
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
80,
106
]
} |
liquid bromine trifluoride and the solid complexes clf ( 2 ) sbf ( 6 ) , brf ( 2 ) sbf ( 6 ) , brf ( 4 ) sb ( 2 ) f ( 11 ) , if ( 4 ) ( sbf ( 6 ) ) ( 3 ) and brf ( 2 ) bif ( 6 ) react spontaneously with radon and radon daughters at 25 degrees c , converting the radioelements to nonvolatile ions and compounds . | NA | {
"id": "C0034629",
"name": "radon",
"pos": [
203,
208
]
} | {
"id": "C0072962",
"name": "radon daughters",
"pos": [
213,
228
]
} |
the reagents can be used in gas-scrubbing units to remove radon and radon daughters from air . | NA | {
"id": "C0034629",
"name": "radon",
"pos": [
58,
63
]
} | {
"id": "C0072962",
"name": "radon daughters",
"pos": [
68,
83
]
} |
the activities of antisera against these fractions suggested that indirect-haemagglutinating or metabolic-inhibiting antibodies can be directed against several different membrane antigens . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
18,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
117,
127
]
} |
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