text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
m.g . are often associated with malignant proliferation of b lymphocytes such as multiple myeloma , waldenstrom 's macroglobulinemia , heavy chain disease as well as some other lymphoproliferative disorders . | NA | {
"id": "C0026764",
"name": "multiple",
"pos": [
81,
89
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
177,
206
]
} |
m.g . are often associated with malignant proliferation of b lymphocytes such as multiple myeloma , waldenstrom 's macroglobulinemia , heavy chain disease as well as some other lymphoproliferative disorders . | NA | {
"id": "C0024419",
"name": "waldenstrom 's macroglobulinemia",
"pos": [
100,
132
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
177,
206
]
} |
m.g . are often associated with malignant proliferation of b lymphocytes such as multiple myeloma , waldenstrom 's macroglobulinemia , heavy chain disease as well as some other lymphoproliferative disorders . | NA | {
"id": "C0018852",
"name": "heavy chain disease",
"pos": [
135,
154
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
177,
206
]
} |
registry holdings systematically collecting pertinent information on the malignancies developed in patients with primary immunodeficiency diseases or in organ transplant recipients maintained on therapeutically-induced immune depression , as well as the observation of tumors occurring in patients treated with immunosuppressive agents and of second malignancies arising after radio- and/or chemotherapy of the primary tumor consistently indicate that depressed immunity is usually associated with an increased incidence of cancer as compared with that expected in the general control populations . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
269,
275
]
} | {
"id": "C0085183",
"name": "second malignancies",
"pos": [
343,
362
]
} |
interestingly , tumor incidence increases with advancing age in both man and animals and experimental tumors are more easily transplanted in old mice than in young adult mice . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
16,
21
]
} | {
"id": "C0027659",
"name": "experimental tumors",
"pos": [
89,
108
]
} |
the present study has demonstrated that ecog is different in selectivity of detection of the endolymphatic hydrops from glycerol test and that the combination of both tests increases the detection rate of the endolymphatic hydrops in meniere 's disease . | NA | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
93,
114
]
} | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
234,
252
]
} |
due to results showing unexpectedly low antibacterial effectiveness of 70 % ( v/v ) ethanol , a series of supplementary experiments with ethanol ( 70 % ( v/v ) and 80 % ( v/v ] and isopropanol ( 60 % ( v/v ] were performed with 10 laboratory staff-members . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
84,
91
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
181,
192
]
} |
all hsv and varicella zoster virus ( vzv ) infections were reactivations , and 9 of 10 patients who developed hsv infections or shed virus had a pre-transplantation hsv igg titer of greater than 10 000 ( elisa ) . | NA | {
"id": "C0008049",
"name": "varicella zoster virus",
"pos": [
12,
34
]
} | {
"id": "C0019372",
"name": "hsv infections",
"pos": [
110,
124
]
} |
the overall majority of clinical problems are related to activated latent infections , viz . recurrent lesions of herpes simplex , herpes zoster with remaining neuralgia in older patients , and in particular herpesvirus infections and reactivation in immunodeficient individuals . | NA | {
"id": "C0019360",
"name": "herpes",
"pos": [
114,
120
]
} | {
"id": "C0019372",
"name": "herpesvirus",
"pos": [
208,
219
]
} |
systemic acyclovir ( acv ) treatment has been shown to have significant effects on shortening the clinical course of first episode genital hsv infections , decreasing the quantity of hsv antibody in convalescent phase serum , without affecting the incidence of recurrences in 6 months of follow-up . | NA | {
"id": "C0019342",
"name": "genital hsv infections",
"pos": [
131,
153
]
} | {
"id": "C0019348",
"name": "hsv",
"pos": [
183,
186
]
} |
perfusion of the pyrrolizidine alkaloid , monocrotaline , through the isolated rat liver resulted in the appearance of ehrlich-positive metabolites in both the perfusate and bile . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloid",
"pos": [
17,
39
]
} | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
42,
55
]
} |
the episcleral fibroblasts , on autoradiographic studies appeared to be the main source of the cells that formed the proliferating tissue in both non-irradiated and irradiated eyes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
15,
26
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
113,
116
]
} |
similar results were obtained with disaccharidases where again the mucosal cells incubated with g. lamblia showed a statistically significant reduction in the activity of lactase , sucrase and maltase compared to that in the control groups . | NA | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
35,
50
]
} | {
"id": "C0038634",
"name": "sucrase",
"pos": [
181,
188
]
} |
both primary chick embryo cell and green monkey kidney cell cultures and diploid fibroblast-like human embryo cells were successfully cultivated on these mc . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
26,
30
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
81,
91
]
} |
the new anthracendione mitoxantrone , an anthraquinone derivate with structural similarities to doxorubicin ( adriamycin ) is active in the treatment of patients with metastatic breast cancer . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
23,
35
]
} | {
"id": "C0003174",
"name": "anthraquinone",
"pos": [
41,
54
]
} |
from this it is concluded that incorporation and metabolism of linoleic acid in different plasma lipids is not identical , although lipid exchange and lipid transfer have been shown for most lipoprotein fractions . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
97,
102
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
191,
202
]
} |
bio-assay evaluation of the three algal proteins gave the following values : protein efficiency ratio , 1.9-2.1 ; | NA | {
"id": "C0600607",
"name": "algal",
"pos": [
34,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
77,
84
]
} |
a progress in liver diagnostics is the use of the isoenzymes of the aspartate aminotransferase and the lactate dehydrogenase as well as of the enzymes of the metabolism of the connective tissue . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
50,
60
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
143,
150
]
} |
clinical findings ( cyanosis , dyspnoea , stasis of the jugular vein , pulse , heart sounds and extrasounds , enlargement of the liver , oedemata ) ; | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
0,
17
]
} | {
"id": "C0010520",
"name": "cyanosis",
"pos": [
20,
28
]
} |
clinical findings ( cyanosis , dyspnoea , stasis of the jugular vein , pulse , heart sounds and extrasounds , enlargement of the liver , oedemata ) ; | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
0,
17
]
} | {
"id": "C0013604",
"name": "oedemata",
"pos": [
137,
145
]
} |
a review of nitrate therapy in stable angina , variant angina , unstable angina and myocardial infarction . | NA | {
"id": "C0002963",
"name": "variant angina",
"pos": [
47,
61
]
} | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
64,
79
]
} |
isosorbide-5-mononitrate ( ismn ) is not subject to first-pass metabolism and has more predictable blood concentrations than isosorbide dinitrate . | NA | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
0,
24
]
} | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
125,
145
]
} |
isosorbide-5-mononitrate is an active metabolite of isosorbide dinitrate and is nearly 100 % bioavailable after oral administration . | NA | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
0,
24
]
} | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
52,
72
]
} |
the effect of propafenon on premature beats was tested in a 24-hour ecg monitoring : propafenon has a significant reducing influence on svpb and vpb in elderly patients . | NA | {
"id": "C0340464",
"name": "premature beats",
"pos": [
28,
43
]
} | {
"id": "C0151636",
"name": "vpb",
"pos": [
145,
148
]
} |
hydrolase cytochemistry in murine rodent decidua , yolk sac , and placenta with special reference to proteases . | NA | {
"id": "C0020289",
"name": "hydrolase",
"pos": [
0,
9
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
101,
110
]
} |
by means of radio-immunoassay the concentration of human growth hormone ( hgh ) was measured in the blood plasma of 61 patients with psoriasis ( 21 suffering from psoriasis vulgaris and 40 with psoriatic arthritis ) , 30 patients with ankylosing spondylitis , 9 with atypical spondylarthritis and 34 patients with diseases of the soft tissue or degenerative joint and spinal column disease . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
133,
142
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
194,
213
]
} |
gfap could be immunohistochemically demonstrated in all 6 primary glial tumors as well as in the metastases of the 3 astrocytomas and of 2 glioblastomas . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
117,
129
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
139,
152
]
} |
according to the reduction in the number of premature beats , the effectiveness of the treatment was similar for patients with heart disease ( group a ) , and for those suffering from an idiopathic arrhythmia ( group b ) . | NA | {
"id": "C0340464",
"name": "premature beats",
"pos": [
44,
59
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
198,
208
]
} |
according to the reduction in the number of premature beats , the effectiveness of the treatment was similar for patients with heart disease ( group a ) , and for those suffering from an idiopathic arrhythmia ( group b ) . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
127,
140
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
198,
208
]
} |
we followed 143 patients who had had typical myocardial transmural infarction ( 82 with `` '' anterior '' '' ) and 61 with `` '' inferior '' '' myocardial infarction ) over a three month period . | NA | {
"id": "C0027051",
"name": "myocardial",
"pos": [
45,
55
]
} | {
"id": "C0340305",
"name": "`` '' infer",
"pos": [
123,
134
]
} |
the study did not confirm a beneficial effect of dextran 70 in combination with dihydroergotamine as compared with dextran alone in regard to thrombotic complications after surgery for hip fracture . | NA | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
49,
59
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
115,
122
]
} |
in sca patients with 2 gene deletions ( homozygous alpha-thalassaemia 2 ) , the mean cell volume , mean cell haemoglobin and hb f were significantly lower ( p less than 0.05 ) , while packed cell volume and hb a2 level were considerably higher ( p less than 0.05 ) than in the sca patients without alpha-thalassaemia . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
109,
120
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
125,
129
]
} |
thirty months after the start of chemotherapy , preleukemic changes were observed in peripheral blood and bone marrow , and acute nonlymphocytic leukaemia ( m5 of the fab classification ) was diagnosed shortly afterwards . | NA | {
"id": "C0023467",
"name": "acute nonlymphocytic leukaemia",
"pos": [
124,
154
]
} | {
"id": "C0023465",
"name": "m5",
"pos": [
157,
159
]
} |
after a 31 months ' course of typical pnh the patient developed a type 1 ( refractory anaemia ) myelodysplastic syndrome ( mds ) which subsequently evolved into type 5 ( refractory anaemia with excess of blasts in transformation ) myelodysplastic syndrome . | NA | {
"id": "C0002893",
"name": "refractory anaemia",
"pos": [
75,
93
]
} | {
"id": "C0002894",
"name": "refractory anaemia with excess of blasts",
"pos": [
170,
210
]
} |
the rate of the clonogenicity of granulocyte macrophage forming cells ( gm-cfu ) in agar was analysed using mononuclear cells from the peripheral blood of cancer patients undergoing total body irradiation ( tbi , 5 patients , 1.5 gy in 15 days ) or hemicorporal irradiation of the lower ( lhbi , 5 patients , 15 gy in 15 days ) or upper ( uhbi , 4 patients , 15 gy in 15 days ) part of the body . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "mononuclear cells",
"pos": [
108,
125
]
} |
two human malignant cell lines were studied : the bewo line of choriocarcinoma cells , which secrete the tumor marker human chorionic gonadotropin ( hcg ) and its alpha-subunit ; | NA | {
"id": "C0018062",
"name": "human chorionic",
"pos": [
118,
133
]
} | {
"id": "C0017963",
"name": "alpha-subunit",
"pos": [
163,
176
]
} |
[ a comparative roentgeno-cephalometric analysis of sagittal jaw relations in patients with angle class i , ii and iii malocclusion ] . | NA | {
"id": "C0399523",
"name": "angle class i",
"pos": [
92,
105
]
} | {
"id": "C0024636",
"name": "malocclusion",
"pos": [
119,
131
]
} |
mgatp failed to protect the enzyme but substituting sulfate , acetate , bicarbonate , or n-tris ( hydroxymethyl ) methyl-2-aminoethane sulfonate anions and preincubation with adp prevented the inactivation . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
52,
59
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
145,
151
]
} |
this method was used to analyze the following compounds : n-hexane , 2,5-dimethylfuran , 2-hexanone , 3-hexanone , hexanal , 1-hexanol , 2-hexanol , 3-hexanol , 5-hydroxy-2-hexanone , gamma-valerolactone , 2,5-hexanedione , and 2,5-hexanediol . | NA | {
"id": "C0025708",
"name": "2-hexanone",
"pos": [
89,
99
]
} | {
"id": "C0019464",
"name": "hexanone",
"pos": [
173,
181
]
} |
the dot-immunobinding method for screening antibodies to proteins on sheets of nitrocellulose has been modified to allow monoclonal antibodies ( mcab ) to the hapten abscisic acid ( aba ) to be screened . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
43,
53
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
121,
142
]
} |
hybridomas secreting mcab with a defined specificity for the hapten can be identified by screening supernatants against the carrier protein and other hapten-protein conjugates with different conjugation bridges or modified hapten structure . | NA | {
"id": "C0007292",
"name": "carrier",
"pos": [
124,
131
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
157,
164
]
} |
picomole analysis of glutathione , glutathione disulfide , glutathione s-sulfonate , and cysteine s-sulfonate by high-performance liquid chromatography . | NA | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
35,
56
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
59,
70
]
} |
a method for simultaneous detection of picomole quantities of glutathione ( gsh ) , glutathione disulfide ( gssg ) , glutathione s-sulfonate ( gsso3h ) , and cysteine s-sulfonate ( cysso3h ) by high-performance liquid chromatography has been developed . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
108,
112
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
117,
128
]
} |
the compounds elute with retention times of 12.5 min for gsh , 27.5 min for cysso3h , 29.8 min for gssg , and 33.0 minutes for gsso3h , with detection limits of 10 , 200 , 10 , and 50 pmol , respectively . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
57,
60
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
99,
103
]
} |
recoveries are 103 % for gsh , 102 % for gssg , 100 % for cysso3h , and 96 % for gsso3h . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
25,
28
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
41,
45
]
} |
alanine was chosen as the gluconeogenic substrate because it is the major gluconeogenic amino acid extracted by the liver and , with lactate , constitutes the bulk of the gluconeogenic precursors . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
88,
98
]
} |
enrichment for the cell type that provides radioprotection was equal to 180 +/- 70 , indicating that phsc and cfu-s are identical . | NA | {
"id": "C0007634",
"name": "cell type",
"pos": [
19,
28
]
} | {
"id": "C0018956",
"name": "phsc",
"pos": [
101,
105
]
} |
evidence is provided that the spleen seeding efficiency ( the f-factor ) of these cells was 0.10 and , therefore , that the average purity of the sorted phsc was 65 % ( range in 15 experiments , 35-110 % ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
82,
87
]
} | {
"id": "C0018956",
"name": "phsc",
"pos": [
153,
157
]
} |
they appeared to be undifferentiated blasts by morphological criteria , the majority of the cells being similar in structure to the phsc previously identified in less purified concentrates . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "phsc",
"pos": [
132,
136
]
} |
if there is residual damage to the host stromal fibroblasts from treatment before transplantation , these cells may not be able to proliferate in vitro . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
48,
59
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} |
hybrids were detected with the help of a monoclonal antibody raised against aaf-guanosine and a second antibody coupled to an enzyme . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
41,
60
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
103,
111
]
} |
in this study , pha- and cona-activated cells ( pac and cac ) were used as stimulators in mixed lymphocyte reactions ( mlr ) using autologous ( auto ) and allogeneic ( allo ) peripheral mononuclear cells as responders . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
155,
165
]
} |
oral treatment with beta-carotene/canthaxanthin raised the median carotenoid levels in uninvolved and involved skin by 170 % and 610 % , respectively , without significantly affecting the vitamin-a composition . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
20,
33
]
} | {
"id": "C0007271",
"name": "carotenoid",
"pos": [
66,
76
]
} |
from our findings and the results of previously published studies , we propose the following conclusions : first , lcs and bgs cells observed in mesenteric lns are the product of the differentiation and maturation of precursor cells pre-existing in the paracortical area of lns caused by dncb stimulation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
217,
232
]
} |
finally , morphological findings suggest that precursor cells of lcs and bgs cells are probably idcs . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
46,
61
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
77,
82
]
} |
colonisation of the forehead by propionibacteria and the composition of both free fatty acid and fatty acid of the triglyceride fraction of skin-surface lipid were studied , and the results were analysed using numerical taxonomic techniques . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
77,
92
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
97,
107
]
} |
skin from hairless mice was incubated with two synthetic retinoids , isotretinoin and etretinate , and the camp content as well as the activity of camp-dependent protein kinase were determined . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
57,
66
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
69,
81
]
} |
human peripheral-blood leukocytes ( pbls ) were found to form rosettes with cultured human epidermal cells or a mouse epidermal cell line ( pam cells ) , but not with fibroblasts , when preincubated with heat-inactivated sera from patients with pemphigus vulgaris . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
101,
106
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
167,
178
]
} |
all 6 flavonoids inhibited soybean 15-lipoxygenase with no differences between glycosides and aglycones , although flavonols appeared more active than flavones . | NA | {
"id": "C0596577",
"name": "flavonoids",
"pos": [
6,
16
]
} | {
"id": "C0060444",
"name": "flavonols",
"pos": [
115,
124
]
} |
all 6 flavonoids inhibited soybean 15-lipoxygenase with no differences between glycosides and aglycones , although flavonols appeared more active than flavones . | NA | {
"id": "C0596577",
"name": "flavonoids",
"pos": [
6,
16
]
} | {
"id": "C0016219",
"name": "flavones",
"pos": [
151,
159
]
} |
in a second set of experiments the effects of bremazocine were antagonized by a per se ineffective dose ( 0.5 mg/kg ) of the selective kappa-opioid receptor antagonist mr 1452 , showing that they were mediated through an interaction with this sub-population of opioid receptors . | NA | {
"id": "C0064239",
"name": "kappa-opioid receptor",
"pos": [
135,
156
]
} | {
"id": "C0034801",
"name": "opioid receptors",
"pos": [
261,
277
]
} |
the alpha 1-adrenoceptor mediated pressor responses of adrenaline and noradrenaline , obtained after pretreatment with propranolol and the selective alpha 2-adrenoceptor antagonist yohimbine , were slightly inhibited by pn 200-110 , without influencing maximal responses . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
70,
83
]
} |
pn 200-110 inhibited the alpha 1-adrenergic pressor effects of noradrenaline better than those of adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
63,
76
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
98,
108
]
} |
for that purpose , dopamine ( da ) , noradrenaline ( na ) and adrenaline ( a ) concentrations were determined by high performance liquid chromatography with electrochemical detection , in peripheral structures and brain nuclei of adult male mice from these three strains . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
37,
50
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
62,
72
]
} |
blood pressure ( mmhg ) , plasma renin activity ( radioimmunoassay of angiotensin i , ng/ml/h ) , plasma concentrations of aldosterone ( direct radioimmuno-assay , pg/ml ) , adrenaline and noradrenaline ( radioenzymatic assay with catechol-o-methyl transferase , pg/ml ) were measured after 1 h of supine rest , 5 mn upright and after walking 1 h . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
174,
184
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
189,
202
]
} |
after a control study , svt was initiated , and encainide ( 0.75 mg/kg ) was infused intravenously in attempt to stop the tachycardia . | NA | {
"id": "C0039240",
"name": "svt",
"pos": [
24,
27
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
122,
133
]
} |
flecainide appears one of the best choices for the treatment of preexcitation syndromes and their related arrhythmias at the present time . | NA | {
"id": "C0032915",
"name": "preexcitation syndromes",
"pos": [
64,
87
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
106,
117
]
} |
[ chloride and sodium chloride concentrations in various organs and the blood serum of hens -- a contribution to the diagnosis of common salt poisoning ] . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
2,
10
]
} | {
"id": "C0037494",
"name": "sodium chloride",
"pos": [
15,
30
]
} |
gsh peroxidase ( gsh-px ) and glutathione reductase ( gssg-r ) had an even distribution along the intestinal tube and among the mucosal cell populations . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
0,
3
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
54,
58
]
} |
the strong effects of bha and 4-methoxyphenol and the more or less inactivity of bht and hydroquinone indicate that the methoxy group of the tested anisoles might be involved in their hyperplasiogenic activity . | NA | {
"id": "C0006506",
"name": "bha",
"pos": [
22,
25
]
} | {
"id": "C0003080",
"name": "anisoles",
"pos": [
148,
156
]
} |
the blood of people living near the river elbe who eat contaminated fish from the river was checked for organochlorines ( n = 136 ) : hexachlorobenzene , hcb , the hexachlorocyclohexanes beta-hch , gamma-hch , octachlorostyrene , ocs , p , p-dde and mercury , hg ( n = 43 ) . | NA | {
"id": "C0020247",
"name": "organochlorines",
"pos": [
104,
119
]
} | {
"id": "C0005038",
"name": "gamma-hch",
"pos": [
198,
207
]
} |
the blood of people living near the river elbe who eat contaminated fish from the river was checked for organochlorines ( n = 136 ) : hexachlorobenzene , hcb , the hexachlorocyclohexanes beta-hch , gamma-hch , octachlorostyrene , ocs , p , p-dde and mercury , hg ( n = 43 ) . | NA | {
"id": "C0020247",
"name": "organochlorines",
"pos": [
104,
119
]
} | {
"id": "C0011038",
"name": "p , p-dde",
"pos": [
236,
245
]
} |
the concentrations ( ng/ml blood ) of ocs ( less than 0.5-9.2 ) and hg ( 1.1-79.2 ) can be attributed to fish consumption , those of the organochlorines -- exept gamma-hch -- are related to age . | NA | {
"id": "C0020247",
"name": "organochlorines",
"pos": [
137,
152
]
} | {
"id": "C0005038",
"name": "gamma-hch",
"pos": [
162,
171
]
} |
the molar ratio between oxidized glutathione ( gssg ) and chromium was calculated by determining the chromium content of the two isolated complex species by flameless atomic absorption spectrometry ( aas ) . | NA | {
"id": "C0008574",
"name": "chromium",
"pos": [
58,
66
]
} | {
"id": "C0991809",
"name": "chromium",
"pos": [
101,
109
]
} |
after dosing 100 microliter ccl4/kg , the response of oct activity was 10- and 20-times higher than that of got and gpt , respectively . | NA | {
"id": "C0002594",
"name": "got",
"pos": [
108,
111
]
} | {
"id": "C0001899",
"name": "gpt",
"pos": [
116,
119
]
} |
the effect of inhaled methanol , ethanol , n-propanol and n-butanol on male reproductive function as measured by the serum concentration of circulating t ( testosterone ) and lh ( luteinizing hormone ) has been investigated . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
22,
30
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
33,
40
]
} |
the animals were exposed to concentrations of these alcohols equal to the current threshold limit values in industry ( methanol : 200 ppm , ethanol : 1000 ppm , n-propanol , n-butanol : 50 ppm ) 6 h a day for up to 1 week . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
52,
60
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
119,
127
]
} |
the animals were exposed to concentrations of these alcohols equal to the current threshold limit values in industry ( methanol : 200 ppm , ethanol : 1000 ppm , n-propanol , n-butanol : 50 ppm ) 6 h a day for up to 1 week . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
119,
127
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
140,
147
]
} |
the great differences in toxic potency of these compounds in vivo may therefore be a result of variation in rate of metabolism and excretion rather than differences in affinity for the ah-receptor . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
116,
126
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
131,
140
]
} |
in rat but not in mouse thymocytes the ecto-atpase was inhibited in vitro by hgcl2 , tricyclohexyltin chloride , di-n-butyltin dichloride , ddt , gamma hch and desipramine . | NA | {
"id": "C0025417",
"name": "hgcl2",
"pos": [
77,
82
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
129,
137
]
} |
it has been demonstrated that fecal ( 90 % ) rather than urinary ( 10 % ) excretion is the major route of elimination of hcb in most species . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
74,
83
]
} | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
97,
117
]
} |
denervation failed to affect reserpine-induced epinephrine depletion while it prevented reserpine-induced norepinephrine depletion only at a low dose of reserpine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
47,
58
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
106,
120
]
} |
hyperthyroid rat heart was studied with the purpose of identifying the mechanism for the significant decrease in total creatine ( free creatine plus phosphocreatine ) observed in this pathology and its consequences on heart function . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
119,
127
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
149,
164
]
} |
use of this method to assess the catabolism of radiolabeled leucine in normal cultured human skin fibroblasts shows that these cells do not accumulate coa esters , but convert leucine mainly to 2-ketoisocaproic acid , glutamate , and hydroxyisovalerate . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} |
the pattern of acid proteinase zymogens , seven pepsinogens ( pg ) and slow moving protease ( smp ) , in normal human gastric mucosa has been reported . | NA | {
"id": "C0014436",
"name": "zymogens",
"pos": [
31,
39
]
} | {
"id": "C0030913",
"name": "pepsinogens",
"pos": [
48,
59
]
} |
three alkaloids of different structure ( codeine , emetine , quinine ) are inactive up to 500 micrograms/ml against the bacteria species and c. albicans . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
6,
15
]
} | {
"id": "C0013974",
"name": "emetine",
"pos": [
51,
58
]
} |
all of the 2-nitroimidazoles tested showed toxicity similar to that previously reported for misonidazole and ro 03-8799 ( 1- ( 2-hydroxy-3-piperidinopropyl ) -2-nitroimidazole ) , two compounds currently undergoing clinical evaluation . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
13,
28
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
92,
104
]
} |
a study concerning possible correlation between maternal weight , smoking , and serum alpha-fetoprotein and subsequent birthweight and gestational age . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
57,
63
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
119,
130
]
} |
maternal serum alpha-fetoprotein ( afp ) levels between 15 and 19 weeks gestation were studied in relation to birthweight , gestational age , maternal weight , and daily cigarette consumption in 1739 pregnancies . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
110,
121
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
151,
157
]
} |
the tissue depletion of iron by desferrioxamine is an alternative therapy which can prevent hemosiderosis or cure organ dysfunction due to iron overload . | NA | {
"id": "C0019114",
"name": "hemosiderosis",
"pos": [
92,
105
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
139,
152
]
} |
inorganic pyrophosphate ( ppi ) and two diphosphonates , ethane-1-hydroxy-1 , 1-diphosphonate ( ehdp ) and dichloromethylene diphosphonate ( cl2mdp ) , were found to inhibit in vitro mineralization induced by matrix vesicle-enriched fractions from chicken epiphyseal cartilage . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
40,
53
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
141,
147
]
} |
the cells resemble fibroblasts in terms of morphology , esterase profile , and production of collagen type 1 . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} |
elemental calcium , phosphorus , and fluorine , as detected by the electron probe , also increased in the metaphyseal region of the f2mbp-treated animals , but no significant differences in the calcium : phosphorous ratio were found among the control , f2mbp , and cl2mbp treatment groups , indicating no alterations in the chemical composition of bone . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
0,
9
]
} | {
"id": "C0031705",
"name": "phosphorous",
"pos": [
204,
215
]
} |
these results suggest that the rdeb fibroblast produces a blister formation factor ( s ) , and that blister formation may be caused by a combination of a metallo-protease , serine protease and sh protease . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
173,
188
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
196,
204
]
} |
the tm and delta hcal for anionic gsls were 16-25 degrees c and 1-3 kcal mol-1 lower than those of neutral gsls with comparable oligosaccharide chains . | NA | {
"id": "C0017978",
"name": "gsls",
"pos": [
34,
38
]
} | {
"id": "C0600570",
"name": "neutral",
"pos": [
99,
106
]
} |
in the relaxation rate studies of the ligands in the presence of the enzyme , conditions were adjusted so that all of the mn2+ that was added resided in the ternary enzyme-mn-ligand complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
69,
75
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
165,
171
]
} |
protamines are mixtures of basic proteins consisting of only seven types of amino acids ( arg , ile , val , ser , pro , ala , and gly ) , arginine ( codon , agr and cgn ) being abundant . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
76,
87
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
130,
133
]
} |
taking advantage of the absence of lysine ( codon , aag ) in the proteins , we determined the misincorporation of this amino acid into protamines in a cell-free translation system consisting of mouse liver ribosomes , protamine mrna , [ 3h ] lysine , [ 14c ] arginine , and seven unlabeled amino acids : ile , val , ser , pro , ala , gly , and met . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
290,
301
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
334,
337
]
} |
the effect of increasing concentrations of the nonionic detergent triton x-100 on catalytic activity , stability , phospholipid content , and aggregational state of solubilized ca2+ ion activated adenosinetriphosphatase ( ca2+-atpase ) of sarcoplasmic reticulum has been investigated . | NA | {
"id": "C0001473",
"name": "adenosinetriphosphatase",
"pos": [
196,
219
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
222,
225
]
} |
nucleus containing cells displayed a high phosphorus level , while platelets showed a low peak of this element . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
42,
52
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
103,
110
]
} |
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