text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
thus , the uptake characteristics of the compound are similar to those of ethylglyoxal bis ( guanylhydrazone ) , but in striking contrast to those of methylglyoxal and glyoxal bis ( guanylhydrazones ) . | NA | {
"id": "C0034338",
"name": "methylglyoxal",
"pos": [
150,
163
]
} | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
168,
175
]
} |
since the configuration of the double bonds in glyoxal , methylglyoxal and propylglyoxal bis ( guanylhydrazones ) has been shown to be identical , the different uptake characteristics are probably only due to differences in side chain size and/or hydrophobicity . | NA | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
47,
54
]
} | {
"id": "C0034338",
"name": "methylglyoxal",
"pos": [
57,
70
]
} |
regarding presynaptic sites , adaptation in the synthesis and release of norepinephrine ( ne ) and presynaptic alpha2-receptors and dopamine autoreceptors occur . | NA | {
"id": "C0206129",
"name": "presynaptic",
"pos": [
10,
21
]
} | {
"id": "C0206128",
"name": "autoreceptors",
"pos": [
141,
154
]
} |
pia 's types can be supplemented with the so called `` '' pseudoventricular haemorrhage '' '' in which the haematoma only bulges into the ventricle and is covered by ependym . | NA | {
"id": "C0019080",
"name": "haemorrhag",
"pos": [
76,
86
]
} | {
"id": "C0018944",
"name": "haemato",
"pos": [
107,
114
]
} |
spontaneous hyperglycemia , glycosuria , hypoinsulinemia , and glucose intolerance were observed in some wbn/kob rats , at about 9 months of age , and in all at the age of 17 months . | NA | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
12,
25
]
} | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
63,
82
]
} |
to see if the fimbrial concentrations of prostaglandin e ( pge ) and prostaglandin f ( pgf ) change in the process of ovulation , these prostaglandins were measured in the fimbriae of one group of 18 doe rabbits using the specific radioimmunoassay ; | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
41,
56
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
136,
150
]
} |
to see if the fimbrial concentrations of prostaglandin e ( pge ) and prostaglandin f ( pgf ) change in the process of ovulation , these prostaglandins were measured in the fimbriae of one group of 18 doe rabbits using the specific radioimmunoassay ; | NA | {
"id": "C0033561",
"name": "prostaglandin",
"pos": [
41,
54
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
136,
150
]
} |
fetal growth curves are then displayed by infant outcome , the bw difference being the deficit birthweight ( dbw ) that may serve as a specific life-death growth standard ( ldgs ) -- a reference system in relation to which fetal growth curves , to be controlled for factors other than infant outcome , may be studied . | NA | {
"id": "C0005910",
"name": "bw",
"pos": [
63,
65
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
95,
106
]
} |
in normally nourished pregnancies this measurement increases in the first two trimesters and decreases in the third , reflecting early pregnancy storage of fat and its release in late gestation to meet the increasing energy needs of the fetus . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
22,
33
]
} | {
"id": "C0032979",
"name": "first",
"pos": [
68,
73
]
} |
[ comparative study on the effect of acetylcarnitine and carnitine on experimental hypoxic heart failure and their interactions with strophanthin k ] . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
37,
52
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
57,
66
]
} |
the efficiency of the inhibitory action of 3 tocols derivatives -- alpha-tocopherol ( alpha-t ) , 2 , 2 , 5 , 7 , 8-pentamethylchromane ( pmc ) and alpha-tocopherylacetate ( alpha-ta ) on lipid peroxidation ( lpo ) in rat liver microsomes was compared . | NA | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
67,
83
]
} | {
"id": "C1999896",
"name": "alpha-tocopherylacetate",
"pos": [
148,
171
]
} |
low ph neither affected the affinity of antagonists ( ( - ) dihydroalprenolol , ( +/- ) alprenolol , ( +/- ) propranolol ) for adrenoreceptors nor the number of binding sites determined by [ 3h ] -dha binding assays . | NA | {
"id": "C0012278",
"name": "dihydroalprenolol",
"pos": [
60,
77
]
} | {
"id": "C0002334",
"name": "alprenolol",
"pos": [
88,
98
]
} |
long chain fatty alcohols , hydrocarbons , waxes , triacylglycerols , diacylglycerols , free fatty acids , cholesterol , cholesterol esters and monoacylglycerols were detected . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
107,
118
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
121,
139
]
} |
mutant ng7 showed altered morphological characteristics and produced more cellulases ( cmcase -- 15 units , fpa -- 6.5 units , cda -- 0.80 units and cellobiase -- 4.7 units/ml ) than its parental strain ( cmcase -- 10 units , fpa -- 4.5 units , cda -- 0.36 units and cellobiase -- 2.7 units/ml ) . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
74,
84
]
} | {
"id": "C0005223",
"name": "cellobiase",
"pos": [
267,
277
]
} |
since both bicarbonate and carbonate are charged molecules , their diffusion may evoke electric potentials and thus there will be interaction with all other ions present in the solution . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
11,
22
]
} | {
"id": "C0007026",
"name": "carbonate",
"pos": [
27,
36
]
} |
such effects have been described in the literature for weak acids and protein solutions of hemoglobin and albumin ( stroeve et al. , 1985 ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
70,
77
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
106,
113
]
} |
male rats were given intraperitoneally dibutyryl cyclic amp ( dbcamp ) , a derivative of cyclic amp , per 100 gm of body weight for 50 days . | NA | {
"id": "C0012054",
"name": "dibutyryl",
"pos": [
39,
48
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
89,
99
]
} |
the cyclic amp of the renal parenchyma , especially the renal medulla , was elevated by more than 100 times after dbcamp administration . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
4,
14
]
} | {
"id": "C0012054",
"name": "dbcamp",
"pos": [
114,
120
]
} |
the present study was undertaken to assess the efficacy of single agent chemotherapy with alpha a-interferon or alpha 2-interferon for metastatic renal cell carcinoma . alpha a and alpha 2-interferon were administered i.m . at a primary dose of 3 x 10 ( 6 ) units/day to 13 patients . | NA | {
"id": "C0002199",
"name": "alpha",
"pos": [
90,
95
]
} | {
"id": "C0021734",
"name": "alpha 2-interferon",
"pos": [
181,
199
]
} |
the hormonal and clinical efficacy of ( d-leu6 ) -des gly-nh2 ( 10 ) -lh.rh ethylamide ( leuprolide , tap 144 ) was investigated with 12 prostatic cancer patients . | NA | {
"id": "C0023610",
"name": "lh.rh",
"pos": [
70,
75
]
} | {
"id": "C0085272",
"name": "leuprolide",
"pos": [
89,
99
]
} |
since the discovery of ketotifen as a protective drug of hypersensitivity reactions against an antigen , there have been numerous works that have demonstrated this action both in food and inhalant allergies . | NA | {
"id": "C0013182",
"name": "drug",
"pos": [
49,
53
]
} | {
"id": "C0020517",
"name": "allergies",
"pos": [
197,
206
]
} |
six years ago the structure of slow reacting substance of anaphylaxis ( srs-a ) , a strongly bronchoconstrictive substance , has been unravelled srs-a proved to be a mixture of different closely related compounds , now denominated as sulfidopeptide leukotrienes . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
72,
77
]
} | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
249,
261
]
} |
sofar the following leukotrienes have been characterized leukotriene a4 , b4 , c4 , d4 , e4 and f4 . | NA | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
20,
32
]
} | {
"id": "C0125631",
"name": "leukotriene a4",
"pos": [
57,
71
]
} |
fibrinogen , the products of degradation of fibrinogen or fibrin , plasminogen and rapid alpha 2 antiplasmin are studied as a function of time . | NA | {
"id": "C0163275",
"name": "products",
"pos": [
17,
25
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
58,
64
]
} |
the close association of mononuclear inflammatory cells and fibroblasts within inflammatory loci during fibroplasia and fibrogenesis has prompted investigations seeking to identify potential intercellular signals linking inflammation and fibrosis . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} |
studies of embryonic chick tendon and cornea fibroblasts with the high-voltage ( 1000 kv ) transmission electron microscope have provided the beginnings of an understanding of how this functional continuum is related to the structural compartments which the cells create . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
45,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
258,
263
]
} |
the rate of free fatty-acid uptake remains unchanged after incubation in a 2 mm kcn containing medium , indicating that in the range of fatty-acid concentrations used in this study , this phenomenon does not require energy . | NA | {
"id": "C0015688",
"name": "free fatty-acid",
"pos": [
12,
27
]
} | {
"id": "C0015684",
"name": "fatty-acid",
"pos": [
136,
146
]
} |
the contributions of uptake , metabolism and excretion to the removal of circulating dopamine ( d ) have been studied in comparison to those of adrenaline ( a ) and noradrenaline ( na ) . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
30,
40
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
45,
54
]
} |
the contributions of uptake , metabolism and excretion to the removal of circulating dopamine ( d ) have been studied in comparison to those of adrenaline ( a ) and noradrenaline ( na ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
144,
154
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
165,
178
]
} |
there were two cases of rupture of left ventricular cysts with systemic embolism , and three ruptures of right ventricular cysts causing pulmonary embolism . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
72,
80
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
137,
155
]
} |
after the exclusion of pacemaker patients and those with arrhythmias ( atrial fibrillation or flutter ) or conduction defects , a close correlation was observed between the two methods . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
57,
68
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
71,
90
]
} |
placental lesions were associated with a decrease in mean placental weight ( 26 g ; p less than 0.001 ) and birth weight ( 220 g ; p less than 0.001 ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
68,
74
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
108,
120
]
} |
trypanosoma cruzi ( american trypanosomiasis or chagas ' disease ) may infect the placenta , with or without fetal transmission ( congenital trypanosomiasis ) . | NA | {
"id": "C0041234",
"name": "chagas",
"pos": [
48,
54
]
} | {
"id": "C0041227",
"name": "trypanosomiasis",
"pos": [
141,
156
]
} |
several drugs are used for malaria chemoprophylaxis : 4 amino-quinolines , antifolics , combinations of sulfonamides and antifolics , and new anti-malarial agents , including mefloquine . | NA | {
"id": "C0034424",
"name": "quinolines",
"pos": [
62,
72
]
} | {
"id": "C0025153",
"name": "mefloquine",
"pos": [
175,
185
]
} |
therefore , the interfoveolar cells which have lost the activity of secretory granule production and are going to undergo physiological degeneration are thought to be highly differentiated elements as a covering epithelium to protect the underlying tissue , resembling in this respect the keratinocyte of the epidermis . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} | {
"id": "C0022567",
"name": "epidermis",
"pos": [
309,
318
]
} |
the following endoscopic findings were found : stasis esophagitis -- 15 ( 2.5 % ) , reflux esophagitis -- 41 ( 6.5 % ) , stenosis of esophagus -- 8 ( 1.3 % ) , cancer of esophagus -- 5 ( 0.8 % ) , hiatal hernia -- 3 ( 0.5 % ) , esophageal varices -- 2 ( 0.3 % ) , leukoplasia -- 1 ( 0.2 % ) , duodeno-gastric biliary reflux -- 173 ( 30.4 % ) , chronic gastritis -- 109 ( 18.2 % ) , gastric ulcer -- 10 ( 1.8 % ) , gastric polyp -- 2 ( 0.4 % ) , gastric cancer -- 1 ( 0.2 % ) , megabulbus -- 9 ( 1.6 % ) , duodenal ulcer -- 10 ( 1.8 % ) and duodenitis -- 5 ( 1.9 % ) . | NA | {
"id": "C0014868",
"name": "esophagitis",
"pos": [
54,
65
]
} | {
"id": "C0014869",
"name": "reflux esophagitis",
"pos": [
84,
102
]
} |
quantitation of fibroblasts revealed that 25-50 per cent in the control suture had the characteristics of contractile cells , but this reached 75 per cent in the resected group . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
158,
161
]
} |
the recommendations for the treatment of somatoform disorders were as follows : brief dynamic psychotherapy , family therapy and excellent medical consultation are the basis for the treatment of hypochondriasis . | NA | {
"id": "C0037650",
"name": "somatoform disorders",
"pos": [
41,
61
]
} | {
"id": "C0020604",
"name": "hypochondriasis",
"pos": [
195,
210
]
} |
they can be prepared either by chemical crosslinking of immunoglobulins with different antigen specificities or by reassortment of the polypeptide chains from two different immunoglobulins to produce hybrid molecules with dual specificity . | NA | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
56,
71
]
} | {
"id": "C1302674",
"name": "chains",
"pos": [
147,
153
]
} |
additionally , the antigen carrying the epitope recognized by moab bw 278/97 is defined as a 72 kd protein , uniquely expressed on a single small cell lung carcinoma . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
19,
26
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
40,
47
]
} |
in our laboratory a large number of , for the most part , new proteins have been detected by immunochemical methods in extracts from human term placentae : namely 3 pregnancy proteins ( sp1 , sp2 and sp3 ) , around 40 soluble placental tissue proteins ( pps ) and at least 11 different solubilized , apparently membrane-associated , tissue proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
62,
70
]
} | {
"id": "C0032974",
"name": "placental",
"pos": [
226,
235
]
} |
in our laboratory a large number of , for the most part , new proteins have been detected by immunochemical methods in extracts from human term placentae : namely 3 pregnancy proteins ( sp1 , sp2 and sp3 ) , around 40 soluble placental tissue proteins ( pps ) and at least 11 different solubilized , apparently membrane-associated , tissue proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
62,
70
]
} | {
"id": "C0025252",
"name": "membrane-associated",
"pos": [
311,
330
]
} |
typical immunomorphological findings in non hodgkin lymphomas ( nhl ) are summarized in respect to lymphocytic nhl ( cll , lymphoplasmocytoid nhl , hairy cell and prolymphocytic leukemia , some lymphomas of peripheral t-lymphocytes ) , to nhl of follicular center cells ( centroblastic-centrocytic , centrocytic nhl ) , to `` '' large cell '' '' nhl ( centroblastic , immunoblastic nhl , large cell nhl derived from t-lymphocytes or `` '' lymphomas '' '' of macrophage origin ) and to lymphoblastic nhl ( derived from t-lymphocytes , pre-b lymphocytes and burkitt-type ) . | NA | {
"id": "C0079772",
"name": "lymphomas",
"pos": [
52,
61
]
} | {
"id": "C0024305",
"name": "tic",
"pos": [
495,
498
]
} |
typical immunomorphological findings in non hodgkin lymphomas ( nhl ) are summarized in respect to lymphocytic nhl ( cll , lymphoplasmocytoid nhl , hairy cell and prolymphocytic leukemia , some lymphomas of peripheral t-lymphocytes ) , to nhl of follicular center cells ( centroblastic-centrocytic , centrocytic nhl ) , to `` '' large cell '' '' nhl ( centroblastic , immunoblastic nhl , large cell nhl derived from t-lymphocytes or `` '' lymphomas '' '' of macrophage origin ) and to lymphoblastic nhl ( derived from t-lymphocytes , pre-b lymphocytes and burkitt-type ) . | NA | {
"id": "C0024301",
"name": "nhl",
"pos": [
64,
67
]
} | {
"id": "C0024305",
"name": "tic",
"pos": [
495,
498
]
} |
typical immunomorphological findings in non hodgkin lymphomas ( nhl ) are summarized in respect to lymphocytic nhl ( cll , lymphoplasmocytoid nhl , hairy cell and prolymphocytic leukemia , some lymphomas of peripheral t-lymphocytes ) , to nhl of follicular center cells ( centroblastic-centrocytic , centrocytic nhl ) , to `` '' large cell '' '' nhl ( centroblastic , immunoblastic nhl , large cell nhl derived from t-lymphocytes or `` '' lymphomas '' '' of macrophage origin ) and to lymphoblastic nhl ( derived from t-lymphocytes , pre-b lymphocytes and burkitt-type ) . | NA | {
"id": "C0024299",
"name": "`` '' lympho",
"pos": [
433,
445
]
} | {
"id": "C0024305",
"name": "tic",
"pos": [
495,
498
]
} |
five patients had no rise in intraocular pressure , 38 had ocular hypertension and 25 had glaucoma as shown by optic disc cupping and field loss . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
59,
78
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
90,
98
]
} |
brain abscesses that developed by direct spread were located nearby the source , whereas metastatic abscesses ( such as cardiogenic or hematogenous ) in most cases spread via the vertebral-basilar system , usually developing in the parieto-occipital regions . | NA | {
"id": "C0006105",
"name": "brain abscesses",
"pos": [
0,
15
]
} | {
"id": "C0000833",
"name": "abscesses",
"pos": [
100,
109
]
} |
cardiac arrhythmias , including the long q-t syndrome , sick sinus syndrome , complete heart block , ventricular tachycardia , and pre-excitation are associated with sudden death . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
0,
19
]
} | {
"id": "C0032915",
"name": "pre-excitation",
"pos": [
131,
145
]
} |
in a randomized , crossover design , each subject received a single oral dose of six liquid capsules and six oral tablets , each capsule or tablet containing 1 mg of the active ingredient . | NA | {
"id": "C0991533",
"name": "oral",
"pos": [
68,
72
]
} | {
"id": "C0006935",
"name": "capsule",
"pos": [
129,
136
]
} |
in a randomized , crossover design , each subject received a single oral dose of six liquid capsules and six oral tablets , each capsule or tablet containing 1 mg of the active ingredient . | NA | {
"id": "C0993159",
"name": "oral tablets",
"pos": [
109,
121
]
} | {
"id": "C0039225",
"name": "tablet",
"pos": [
140,
146
]
} |
molecular forms of immunoreactive adrenocorticotropin ( acth ) , beta-lipotropin ( beta-lph ) ( beta-endorphin ( beta-end ) , human nh-2-terminal ( hnt ) of pro-opiomelanocortin ( pomc ) , and gamma-3-melanotropin ( gamma-3-msch ) were studied in plasma , csf and urine of a patient with nelson 's syndrome by molecular sieving and concanavalin a ( con a ) -sepharose chromatography . | NA | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
65,
80
]
} | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
157,
177
]
} |
changes in amino-acid neurotransmitters and camp in cerebral-spinal fluid from children and rabbits with epilepsy and convulsions . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
105,
113
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
118,
129
]
} |
[ nle4 , d-phe7 ] -alpha-msh also exhibits a more sustained effect than alpha-msh on tyrosinase after removal of the melanotropins from the incubation medium . | NA | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
19,
28
]
} | {
"id": "C0026667",
"name": "melanotropins",
"pos": [
117,
130
]
} |
in contrast , under the same experimental conditions [ nle4 , d-phe7 ] -alpha-msh treatment induced tyrosinase activity 2-3 fold above basal level , and maintained remarkable stimulatory effects up to 72 h following melanotropin removal . | NA | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
72,
81
]
} | {
"id": "C0026667",
"name": "melanotropin",
"pos": [
216,
228
]
} |
when the exposure time to melanotropins was reduced to 4 h , alpha-msh failed to elicit significant tyrosinase activity , whereas [ nle4 , d-phe7 ] -alpha-msh stimulated significant tyrosinase activity during the first 24 h subsequent to melanotropin removal . | NA | {
"id": "C0002302",
"name": "alpha-msh",
"pos": [
61,
70
]
} | {
"id": "C0026667",
"name": "melanotropin",
"pos": [
238,
250
]
} |
galnh2 treatment increases acid ph glycosidase activity , while it decreases intermediate ph alpha-mannosidase and alpha-glucosidase activities . beta-d-glucosidase , beta-d-mannosidase and beta-d-n-acetylglucosaminidase activities , measured at acid ph , increase more than 2-fold in the galnh2-treated rats compared to controls . alpha-d-glucosidase activity measured at intermediate ph decreases 2.5-fold in the experimental rats . alpha-l-fucosidase and acid phosphatase activities are not significantly changed by galnh2 treatment . alpha-d-mannosidase activity can be separated into 2 fractions by ion exchange chromatography . | NA | {
"id": "C0051350",
"name": "alpha-mannosidase",
"pos": [
93,
110
]
} | {
"id": "C0024746",
"name": "mannosidase",
"pos": [
546,
557
]
} |
intermediate ph alpha-d-mannosidase optimum is decreased alpha-d-mannosidase activities have been observed in humans with aap deficiency . alpha-glucosidases and alpha-mannosidases play a crucial role in glycoprotein synthesis . | NA | {
"id": "C0024746",
"name": "mannosidase",
"pos": [
24,
35
]
} | {
"id": "C0051350",
"name": "alpha-mannosidases",
"pos": [
162,
180
]
} |
the membranes exhibited about 31 , 33 and 42 mumol pi/mg protein/h of na , k-atpase , magnesium-dependent atpase and calcium-dependent atpase activities , respectively , in the presence of 4 mmol/l atp . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
77,
83
]
} | {
"id": "C0001477",
"name": "magnesium",
"pos": [
86,
95
]
} |
these repeats encode antigenic epitopes that in several proteins have been shown to be immunodominant . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
21,
30
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
31,
39
]
} |
furthermore , zotepine and chlorpromazine-hcl produced no great differences among the various regional 5ht1 receptors , while butyrophenones , haloperidol and spiperone showed remarkable differences . | NA | {
"id": "C0006525",
"name": "butyrophenones",
"pos": [
126,
140
]
} | {
"id": "C0037956",
"name": "spiperone",
"pos": [
159,
168
]
} |
the classification and etiopathogenesis of esophageal diverticula is discussed on the basis of our experience with the surgical management of 74 such diverticula ( 51 parapharyngeal , 7 thoracic , 167 epiphrenic ) . | NA | {
"id": "C0014854",
"name": "esophageal diverticula",
"pos": [
43,
65
]
} | {
"id": "C0012817",
"name": "diverticula",
"pos": [
150,
161
]
} |
the relationship between postoperative weight loss after vertical banded gastroplasty in morbidly obese patients and preoperative serum triglycerides , cholesterol , hdl-cholesterol , uric acid and fasting plasma glucose was evaluated . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
152,
163
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
166,
181
]
} |
after mild aldehyde fixation ( 4 % formaldehyde and 0.5 % glutaraldehyde for 30 min ) , enterocyte brush border , vesicles and lysosomes as well as goblet cell golgi apparatus and mucin are intensely stained after 30-60 min . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
11,
19
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
58,
72
]
} |
the beta-glucuronidase present in mouse 3t3 fibroblasts and mouse peritoneal macrophages was clearly identified by indirect immunofluorescence , using the antiserum and an fitc-conjugated second antibody , while human fibroblasts with normal levels of beta-glucuronidase activity did not fluoresce when tested with the same reagents . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
155,
164
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
195,
203
]
} |
a range of human fibroblasts , human neuroblastoma and rat glioma cells did not fluoresce when incubated with the antibody but did fluoresce after they had been co-cultured for 24 h with mouse macrophages , showing that mouse beta-glucuronidase had been transferred from adherent macrophages into adjacent recipient cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
17,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
316,
321
]
} |
we have investigated the distribution of the basement membrane proteins laminin and type iv collagen , and the intermediate filament proteins vimentin and prekeratin , in these three cell types using immunofluorescence techniques . | NA | {
"id": "C0021769",
"name": "intermediate filament",
"pos": [
111,
132
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
142,
150
]
} |
both these antibodies were at their highest concentration about 9-11 days after inoculation , whereas neutralizing antibodies were present only at very low concentrations at that time . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
11,
21
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
102,
125
]
} |
a second inoculation of virus at 42 days induced an anamnestic antibody response to the spike and membrane proteins and also for the neutralizing antibodies . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
63,
71
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
133,
156
]
} |
during reaction with substrate at ph 9.6 , greater than 50 % of the ap is released as free enzyme and the released enzyme has the same activity as enzyme found in the eic . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
91,
97
]
} | {
"id": "C0026741",
"name": "eic",
"pos": [
167,
170
]
} |
using 131i-eic and 125i-m315 , it was determined that the lack of a constant stoichiometry in the linear region was due to differences in the amount of enzyme bound . | NA | {
"id": "C0026741",
"name": "eic",
"pos": [
11,
14
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
152,
158
]
} |
on the contrary , retinopexy is recommended when the vitrectomy-silicone technique is used in order to remove the silicone oil as safely as possible : this causes a dilemma in the case of a macular break . | NA | {
"id": "C0037114",
"name": "silicone",
"pos": [
64,
72
]
} | {
"id": "C0037111",
"name": "silicone",
"pos": [
114,
122
]
} |
hyperbilirubinemic female newborn showed higher plasma gh concentrations in comparison with hyperbilirubinemic males and with controls . | NA | {
"id": "C0857007",
"name": "hyperbilirubinemic",
"pos": [
0,
18
]
} | {
"id": "C0020433",
"name": "hyperbilirubinemic",
"pos": [
92,
110
]
} |
acute otitis media is a common pediatric infection that requires appropriate evaluation of the young child to assure that there are no accompanying systemic infections or complications . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
41,
50
]
} | {
"id": "C0243026",
"name": "systemic",
"pos": [
148,
156
]
} |
ruptures of the long head of the biceps are generally associated with rotator cuff disease , but a localized process secondary to trauma or injections may account for some ruptures . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
130,
136
]
} | {
"id": "C3203359",
"name": "ruptures",
"pos": [
172,
180
]
} |
monoclonal antibody hb-2d will bind to haemoglobin a2 but not to foetal haemoglobin suggesting that delta-but not gamma-chain also expresses the hb-2d determinant . | NA | {
"id": "C0015936",
"name": "foetal haemoglobin",
"pos": [
65,
83
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
145,
147
]
} |
the distribution of the antigens in different rat strains , including the mutant wf/fz , clearly establish the rt7 antigenic system as a polymorphic diallelic system , whereas the recognized l-c antigenic determinant is monomorphic and present on the lymphocytes of all rat strains tested . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
24,
32
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
195,
216
]
} |
it would be suggested from these observations that the formation of saline extractable ldl-gag complexes would be the early events in aortic intima when plasma ldl penetrated from circulation system and that not only ds and/or heparan sulfate ( hs ) but also cs-4-s and/or cs-6-s have an important role on the progression of atherosclerosis . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
91,
94
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
227,
242
]
} |
phorbol ester ( pma ) in concentration 5 and 10 ng ml-1 blocks cytokinesis of the second maturation division in mouse oocytes . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
0,
13
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
16,
19
]
} |
the effect of 4- ( 4'-chlorobenzyloxy ) benzoic acid ( mii ) , a metabolite of a new hypolipidemic agent 4- ( 4'-chlorobenzyloxy ) benzyl nicotinate ( kcd-232 ) , on lipid synthesis and cell growth was studied in human skin fibroblasts ( hsf ) , mouse skin fibroblasts ( msf ) and other rodent-derived cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
224,
235
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
302,
306
]
} |
these results suggested a possibility that the different effects of mii on the growth of hsf and msf might be due partly to differences in the effect of mii on fatty acid synthesis between human and rodent cells . | NA | {
"id": "C0016030",
"name": "msf",
"pos": [
97,
100
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
206,
211
]
} |
the inherent assumption of these estimates , however , requires that the extent of sequential elimination of the generated mi be identical to the extent of metabolism of preformed mi . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
94,
105
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
156,
166
]
} |
nicotinic ach receptor was expressed in xenopus oocytes by injecting mrnas produced from cloned cdnas encoding the four subunits of ach receptor of torpedo californica . | NA | {
"id": "C0034830",
"name": "nicotinic",
"pos": [
0,
9
]
} | {
"id": "C0034792",
"name": "ach receptor",
"pos": [
132,
144
]
} |
hemagglutinating antibodies to mycoplasma hominis were present in 30 of 83 infertile , 15 of 40 pregnant and 5 of 20 post-partum females and 20 of 82 infertile males in contrast to only 2 of 21 fertile females and 5 of 25 fertile males . | NA | {
"id": "C0021359",
"name": "infertile",
"pos": [
75,
84
]
} | {
"id": "C0021364",
"name": "infertile males",
"pos": [
150,
165
]
} |
[ the role of endothelial cells in the endotoxin ( lps ) -induced vasodilatory response of perfused hamster arterial preparations ] . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
39,
48
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
51,
54
]
} |
[ studies on the combination action of sisomicin , gentamicin and cefmenoxime , ceftizoxime , cefoperazone , cefotetan against serratia marcescens and pseudomonas aeruginosa ] . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
39,
48
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
51,
61
]
} |
the combined actions of sisomicin ( siso ) , gentamicin ( gm ) and cefmenoxime ( cmx ) , ceftizoxime ( czx ) , cefoperazone ( cpz ) , cefotetan ( ctt ) against s. marcescens ifo-3735 and p. aeruginosa ifo-12689 were investigated . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
24,
33
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
45,
55
]
} |
the synergistic effect of the combinations of siso-cmx , siso-czx , siso-cpz , siso-ctt , gm-cmx , gm-czx , gm-cpz and gm-ctt using the checker board dilution method on s. marcescens ifo-3735 and p. aeruginosa ifo-12689 were found . | NA | {
"id": "C0037209",
"name": "siso",
"pos": [
46,
50
]
} | {
"id": "C0017436",
"name": "gm",
"pos": [
119,
121
]
} |
especially the minimum fic index value of combination of siso-ctt and gm-ctt were rather low as 0.14 and 0.13 , respectively and these synergistic effect was remarkably strong on s. marcescens ifo-3735 . | NA | {
"id": "C0037209",
"name": "siso",
"pos": [
57,
61
]
} | {
"id": "C0017436",
"name": "gm",
"pos": [
70,
72
]
} |
it is the first drug in the world of monobactam series with the structural characteristic of monocyclic beta-lactam . | NA | {
"id": "C0026458",
"name": "monobactam",
"pos": [
37,
47
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
104,
115
]
} |
in normal subjects and diabetic patients whose urinary excretion rate of albumin was normal or increased only slightly ( 10 to 100 micrograms/min ) , the pattern of urinary albumin included a main band with normal pi ( 4.7 ) and some remarkable amounts of more anionic bands ( pi between 4.0 and 4.7 ) if compared to the native protein , which was characterized as glycosyl albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
73,
80
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
328,
335
]
} |
most of these patients demonstrate cardiovascular abnormalities , ranging from cardiac arrhythmias and atrial fibrillation to hypertension . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
79,
98
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
103,
122
]
} |
of a total of 3,366 cases of malignant lymphoma in china reviewed histopathologically , t-cell lymphomas accounted for an average of 26.1 % among all non-hodgkin 's lymphomas . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
29,
47
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
150,
174
]
} |
of a total of 3,366 cases of malignant lymphoma in china reviewed histopathologically , t-cell lymphomas accounted for an average of 26.1 % among all non-hodgkin 's lymphomas . | NA | {
"id": "C0079772",
"name": "t-cell lymphomas",
"pos": [
88,
104
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
150,
174
]
} |
in addition , in this study a high trans fat was less tumor promoting than was a blend of fats that simulated the dietary fat composition of the united states and had a lower level of trans fatty acids . | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
90,
94
]
} | {
"id": "C0012171",
"name": "dietary",
"pos": [
114,
121
]
} |
these studies indicated that : dopaminergic functions of the globus pallidus are influenced , like the striatum , by manipulations of the substantia nigra : nt and ghb likely act via different mechanisms to effect nigral dopamine-containing cells ; | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
31,
43
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
221,
229
]
} |
the specific binding of the 125i-bolton-hunter labeled tachykinins substance k ( bhsk ) , eledoisin ( bhe ) , and substance p ( bhsp ) was examined in crude membrane suspensions and by autoradiography in rat submaxillary gland . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
55,
66
]
} | {
"id": "C0038581",
"name": "substance k",
"pos": [
67,
78
]
} |
the specific binding of the 125i-bolton-hunter labeled tachykinins substance k ( bhsk ) , eledoisin ( bhe ) , and substance p ( bhsp ) was examined in crude membrane suspensions and by autoradiography in rat submaxillary gland . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
55,
66
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
114,
125
]
} |
recently , increases in cerebrospinal fluid and hypothalamic levels of beta-endorphin have been reported during endotoxin ( lps ) - and il1-induced fevers , suggesting that this opioid may participate in the modulation of il1 effects in the cns . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
112,
121
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
124,
127
]
} |
when incubated in vitro with anterior pituitary cells in monolayer culture , npy produced no significant change in release of pituitary hormones . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
29,
47
]
} | {
"id": "C0032015",
"name": "pituitary hormones",
"pos": [
126,
144
]
} |
based on the effects of amphetamine on central and peripheral norepinephrine and epinephrine disposition observed in other studies , the data also suggest that npy-ir and catecholamine dispositions are not directly correlated and may be inversely related in some tissue . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
62,
76
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
81,
92
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.