text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
during icteric episodes , conjugated bilirubinemia , alkaline phosphatase , and to a lower degree transaminases , were increased ; | NA | {
"id": "C0022346",
"name": "icteric",
"pos": [
7,
14
]
} | {
"id": "C0020433",
"name": "bilirubinemia",
"pos": [
37,
50
]
} |
a correlation was found between the amount of ifn produced by the primed or superinduced human embryo fibroblasts and the quantity of extractable polyadenylated translatable ifn mrna in these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
102,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
at ii increased apomorphine stereotypy and the effect was antagonized by saralasin and haloperidol and partly by alpha-methyl-para-tyrosine ( alpha-mpt ) ( an inhibitor of dopamine synthesis ) . | NA | {
"id": "C0003009",
"name": "at ii",
"pos": [
0,
5
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
73,
82
]
} |
however , although ethylglyoxal and propylglyoxal bis ( guanylhydrazone ) appear to utilize the putative polyamine carrier for their cellular entry , their cellular accumulation , in contrast to that of glyoxal and methylglyoxal bis ( guanylhydrazone ) , is not stimulated by putrescine and spermidine deprivation produced by inhibitors of ornithine decarboxylase . | NA | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
24,
31
]
} | {
"id": "C0034338",
"name": "methylglyoxal",
"pos": [
215,
228
]
} |
however , although ethylglyoxal and propylglyoxal bis ( guanylhydrazone ) appear to utilize the putative polyamine carrier for their cellular entry , their cellular accumulation , in contrast to that of glyoxal and methylglyoxal bis ( guanylhydrazone ) , is not stimulated by putrescine and spermidine deprivation produced by inhibitors of ornithine decarboxylase . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
276,
286
]
} | {
"id": "C0037871",
"name": "deprivation",
"pos": [
302,
313
]
} |
while 6-azauridine displays a rather selective inhibitory effect , biological action of 5-azacytidine reflects the polyvalent inhibitory mechanism of the drug ( interaction with pyrimidine synthesis de novo , incorporation into rna and dna , depressed maturation of ribosomal rna , inhibition of rna and dna methylation , etc . ) and the analog displays pronounced cytostatic and immunosuppressive activity . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
266,
279
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
296,
299
]
} |
otitis media is the most common pediatric disease as a complication of the upper respiratory infection and at least 10 % of the otitis prone children will suffer from prolonged episodes of minor conductive hearing loss and communication disorder due to the presence of middle ear effusion ( mee ) . | NA | {
"id": "C0029882",
"name": "otitis media",
"pos": [
0,
12
]
} | {
"id": "C0029877",
"name": "otitis",
"pos": [
128,
134
]
} |
alpha-1-at could be saturated by trypsin and elastase immediately , and only alpha 2-m could be saturated by papain ( classical thiol protease ) . | NA | {
"id": "C0030346",
"name": "papain",
"pos": [
109,
115
]
} | {
"id": "C0010661",
"name": "thiol protease",
"pos": [
128,
142
]
} |
secretory iga , secretory component and pathogen specific antibodies in the middle ear effusion during an attack of acute and secretory otitis media . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
0,
13
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
16,
35
]
} |
the role of humoral factors in the pathogenesis of gentamicin and tobramycin aminoglycoside-induced acute renal failure was studied in rats . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
51,
61
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
77,
91
]
} |
plasma and urinary kallikrein levels were measured in aminoglycoside-treated rats , as was in vitro effect of of these antibiotics on plasma kallikrein activity and prekallikrein activation by dextran sulfate . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
19,
29
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
165,
178
]
} |
both aminoglycosides at concentrations of 0.1 mg/ml inhibited dextran sulfate activation of plasma prekallikrein , and 2.0 micrograms/ml tobramycin , but not gentamicin , inhibited the hydrolysis of h-d-pro-phe-arg-p-nitroanilide by rat plasma . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
5,
20
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
158,
168
]
} |
this inhibition was shown to be specific in two ways : ( i ) the same h-2kb-containing vesicles did not inhibit nonspecific conjugate formation , and ( ii ) control vesicles containing the same amounts of lipid , cytoskeletal proteins , and purified h-2k proteins inhibited conjugate formation but only at significantly higher h-2k concentrations , indicating the specificity of the response with the vesicles containing h-2kb . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
213,
234
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
255,
263
]
} |
ma158.2 , a rat monoclonal antibody with binding specificity for cells of the monocyte-macrophage lineage , reacts with an antigen ( 158.2 ) whose expression is enhanced on mononuclear cells activated to the tumoricidal phenotype by treatment with lymphokine supernatant containing macrophage activating factor ( maf ) . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
248,
258
]
} | {
"id": "C0079786",
"name": "macrophage activating factor",
"pos": [
282,
310
]
} |
immune responses to t-dependent and t-independent antigens during visceral leishmaniasis in mice : evidence for altered t-cell regulation of immune responses to non-parasite antigens . | NA | {
"id": "C0003340",
"name": "t-independent antigens",
"pos": [
36,
58
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
174,
182
]
} |
these two effects were exerted by antibodies against epitopes on resting t cells but not by those directed to activation epitopes . | NA | {
"id": "C0282580",
"name": "epitopes",
"pos": [
53,
61
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
121,
129
]
} |
kinetic studies showed that when m1-a5 cells were separated from nsc by a dialysis tubing in marbrook vessels , the m1-a5 cells required a minimum of 8 hr incubation period before suppressor cell activity could be demonstrated in precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
39,
44
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
230,
245
]
} |
exposure of chinese hamster ovary and african green monkey kidney cells to t-2 mycotoxin resulted in several morphological changes which were related to inhibition of protein synthesis , the basic in vitro mechanism of action of the toxin . | NA | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
79,
88
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
233,
238
]
} |
the osteoclastic giant cell tumor of the pancreas is a rare primary neoplasm that by light and electron microscopy mimics giant cell tumor of bone . | NA | {
"id": "C0017525",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0206638",
"name": "giant cell tumor of bone",
"pos": [
122,
146
]
} |
the specific cytologic diagnosis of follicular carcinoma is 75 % accurate , and that of follicular variant of papillary carcinoma is over 95 % accurate . | NA | {
"id": "C0206682",
"name": "follicular carcinoma",
"pos": [
36,
56
]
} | {
"id": "C0206683",
"name": "follicular variant",
"pos": [
88,
106
]
} |
repeated neurographic examinations were performed during and after the pregnancies of 32 diabetic women who had no signs of neuropathy before pregnancy or at the initial examination during the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
142,
151
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
193,
208
]
} |
furthermore , the incorporation of [ 3h ] leucine into the insulin fraction was suppressed by 10 mm tris , but the sum of the radioactivity of both proinsulin and insulin fraction were not influenced . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
148,
158
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
163,
170
]
} |
to clarify whether or not physiological glycemic excursions and/or plasma insulin profiles contribute to the normalization of the exaggerated glucagon response in diabetes mellitus , the following 4 investigations were conducted on each of 7 non-obese , non-insulin-dependent diabetic ( niddm ) , and 8 insulin-dependent diabetic ( iddm ) subjects , with the aid of aep . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
163,
180
]
} | {
"id": "C0011860",
"name": "non",
"pos": [
254,
257
]
} |
comparing the antibody solutions obtained with mc insulin ( mc-lig-sol ) or cr insulin ( cr-lig-sol ) , the content of iba in cr-lig-sol was higher than in mc-lig-sol , but the content of proinsulin-binding antibody ( pba ) in mc-lig-sol was very small and statistically lower than that in cr-lig-sol ( p less than 0.01 ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
50,
57
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
188,
198
]
} |
by adding native proinsulin in a similar assay system , the pba titer obtained with cr insulin was suppressed more than that extracted with mc insulin . | NA | {
"id": "C0033362",
"name": "pba",
"pos": [
60,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
143,
150
]
} |
twelve type ii diabetics were treated with gliclazide , a potent hypoglycaemic sulfonylurea , for 5 months . | NA | {
"id": "C0017631",
"name": "gliclazide",
"pos": [
43,
53
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
79,
91
]
} |
the evaluation of the results was performed by clinical , radiological ( x-ray , ultrasounds , computerized tomography ) and immunological investigations ( monitoring of indirect haemoagglutinating antibodies , specific ige , lymphocytic blastization , circulating immune complexes , etc . ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
198,
208
]
} | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
253,
281
]
} |
among the compounds tested , 4'-epi-tetrahydropyranyl-adriamycin appeared to be the least powerful effector , requiring a significantly higher concentration for 50 % inhibition of oxidation than doxorubicin and the other analogues examined . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
29,
30
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
195,
206
]
} |
the therapeutic index of aclarubicin ( efficacy related to toxicity ) is higher than that of doxorubicin and daunorubicin , using a proper dose schedule . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
93,
104
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
109,
121
]
} |
single dose therapy of aclarubicin shows only marginal efficacy , whereas multiple divided dose therapy exhibits efficacy comparable to that of doxorubicin and daunorubicin . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
144,
155
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
160,
172
]
} |
the authors are presently investigating the anthracyclines , particularly members of the daunomycin and nogalamycin families , in an effort to better understand their behaviour at the molecular level . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
89,
99
]
} | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
104,
115
]
} |
of the aminoglycosides , only amikacin ( mic90 = 32 mg/l ) showed satisfactory activity , whereas among beta-lactam antibiotics , cefotaxime , ceftriaxone and moxalactam ( mic90 = 32 mg/l ) were more active than cefoperazone ( mic90 = 128 mg/l ) , cefsulodin ( mic90 = 128 mg/l ) , piperacillin ( mic90 = 512 mg/l ) and azlocillin ( mic90 = 1024 mg/l ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
130,
140
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
143,
154
]
} |
the more recently synthesised 4-quinolones showed considerably greater activity than nalidixic acid and pipemidic acid against clinical isolates of haemophilus influenzae and streptococcus pneumoniae . | NA | {
"id": "C0358919",
"name": "4-quinolones",
"pos": [
30,
42
]
} | {
"id": "C0027353",
"name": "nalidixic acid",
"pos": [
85,
99
]
} |
plasma and whole blood pharmacokinetics of epirubicin ( 4'-epidoxorubicin , epidx ) , a new doxorubicin ( dx ) analogue with an improved spectrum of activity and lower toxicity , were investigated in advanced cancer patients after i.v . bolus administration . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
56,
57
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
92,
103
]
} |
the high hepatic clearance of the new doxorubicin analogue epirubicin ( 4'-epidoxorubicin , epidx ) suggests a possible use of this drug in local and regional therapy where a first pass through the liver is required before the drug can reach systemic circulation . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
38,
49
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
72,
73
]
} |
all of the more recently synthesised 4-quinolones showed considerably greater activity than the parent compounds , nalidixic acid , pipemidic acid and cinoxacin , against the range of organisms used in this study . | NA | {
"id": "C0358919",
"name": "4-quinolones",
"pos": [
37,
49
]
} | {
"id": "C0027353",
"name": "nalidixic acid",
"pos": [
115,
129
]
} |
using several well-characterized beta-lactamases isolated from gram-negative bacteria , the interactions of cefmenoxime , a new methoxy-imino-amino-2-thiazol cephalosporin were compared with those of cefotaxime , lamoxactam , cefoperazone and ceftazidime . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
108,
119
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
200,
210
]
} |
microacidimetry showed poor interactions of cefmenoxime with penicillinase tem-1 ( low vm , poor affinity ) whereas it showed a high affinity for the cephalosporinases , as is also the case for cefotaxime or lamoxactam . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
44,
55
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
194,
204
]
} |
effect of isoniazid ( inh ) and its metabolites e.g . mono and diacetyl hydrazines ( mah and dah respectively ) was studied on circulating and tissue folates in mice ( a species susceptible to inh tumorigenicity ) and rats ( a species resistant to inh carcinogenicity ) . | NA | {
"id": "C0020233",
"name": "hydrazines",
"pos": [
72,
82
]
} | {
"id": "C0022209",
"name": "carcinogenicity",
"pos": [
252,
267
]
} |
reduction of infarct size by ibuprofen , neutrophil antiserum , and free radical scavengers indicates that neutrophils and oxygen radicals participate in producing the irreversible damage to the myocardium during ischemia and reperfusion . | NA | {
"id": "C0021308",
"name": "infarct",
"pos": [
13,
20
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
213,
221
]
} |
oxidation of hemoglobin to methemoglobin under aerobic conditions is induced by nitrite , catalyzed by methemoglobin in the presence of hydrogen peroxide , and inhibited by chemical reagents ranging from cysteine and ascorbic acid to sulfite . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
13,
23
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
103,
116
]
} |
the autocatalytic stage for hemoglobin oxidation results from nitrogen dioxide formed from nitrite through the peroxidase activity of methemoglobin . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
28,
38
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
134,
147
]
} |
the extent of fatty acid release was roughly correlated with the degree of fatty acid unsaturation . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
14,
24
]
} | {
"id": "C0015690",
"name": "fatty acid unsaturation",
"pos": [
75,
98
]
} |
4-aminophenazone ( an oxidation product of both amidopyrine/aminopyrine and isopyrine ) , 4-hydroxyphenazone and some dietary catechols ( and ascorbate ) , are also quenchers of oxy radical-associated cl . | NA | {
"id": "C0002696",
"name": "4-aminophenazone",
"pos": [
0,
16
]
} | {
"id": "C0002586",
"name": "aminopyrine",
"pos": [
60,
71
]
} |
glutathione sulfonate and the disulfide gssg were detected as oxidation products from gsh under conditions where phase ii chemiluminescence was observed . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
40,
44
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
86,
89
]
} |
the phospholipid content showed a less significant positive correlation whilst the cholesterol ester content and the cholesterol : phospholipid molar ratio did not correlate with heat sensitivity . | NA | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
83,
100
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
117,
128
]
} |
after reinfection with t. rangeli , haemagglutinant antibodies in immune-sera of both mice and opossums , were detected . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
52,
62
]
} | {
"id": "C0020960",
"name": "immune-sera",
"pos": [
66,
77
]
} |
our results may help to shed light on a rationale for multiple organ failure and on why vasodilator therapies often are ineffective in the treatment of circulatory shock and trauma . | NA | {
"id": "C0026766",
"name": "multiple organ failure",
"pos": [
54,
76
]
} | {
"id": "C0036974",
"name": "circulatory shock",
"pos": [
152,
169
]
} |
ace could be extensively purified by affinity chromatography with captopril ( d-3-mercapto-2-methylpropanoyl-l-proline ) , an orally active antihypertensive agent and a potent inhibitor of this enzyme . | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
66,
75
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
111,
118
]
} |
linear regression analysis showed average ice crystal size to have a significant correlation coefficient to t1 relaxation time and to water content . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
42,
45
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
134,
139
]
} |
path analysis showed that both water content and t2 relaxation time were less directly correlated with ice crystal size . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
31,
36
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
103,
106
]
} |
results of this study suggested that among various sources of the indoor pollution , smoking by mother had the strongest effect on respiratory diseases , especially asthmatic bronchitis of young children , while the use of various types of stoves including non-ventilated kerosene stoves was not related significantly to the prevalence rate of respiratory diseases of those children except an increased rate of frequent common cold in children of households having an air conditioner ( s ) . | NA | {
"id": "C0728836",
"name": "of young children",
"pos": [
186,
203
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
435,
443
]
} |
[ genetic etiological factors in temporomandibular joint pain dysfunction syndrome . study of hla-a and hla-b antigens ] . | NA | {
"id": "C0019721",
"name": "factors",
"pos": [
22,
29
]
} | {
"id": "C0019737",
"name": "hla-b antigens",
"pos": [
104,
118
]
} |
actions of : human growth hormone resultant from hypophysis : hgh h ( contaminated by beta lph 1 % ) or produced by bacteria hgh b ( pure ) , beta lph resultant from human hypophysis , one of the somatomedins : multiplication stimulating activity ( msa ) , produced from a culture of rat hepatocytes , are considered in lipolysis of rat adipocytes `` '' in vitro '' '' : basal , stimulated by epinephrine ( 0.1 and 1 microgram/ml ) , and when insulin is present ( 0.1 and 1 mui/ml ) , during two periods i : 0-1 h 30 , ii : 1 h 30 - 4 h ( hormonal addition at time 0 ) . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
196,
208
]
} | {
"id": "C0021666",
"name": "multiplication stimulating activity",
"pos": [
211,
246
]
} |
biphasic action : antilipolytic , lipolytic , ascertained with a pure growth hormone : hgh b `` '' in vitro '' '' represents an effect `` '' per se '' '' , non mediated by an eventual `` '' in vivo '' '' action of somatomedins . | NA | {
"id": "C0037663",
"name": "growth",
"pos": [
70,
76
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
87,
90
]
} |
a new anticancer agent , uft which is a mixture of 1- ( 2-tetrahydrofuryl ) -5-fluorouracil and uracil in a molar ratio of 1:4 was administered orally at a dose of 600 mg/day every day . | NA | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
77,
91
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
96,
102
]
} |
when the neuroactive amino acids , glycine , glutamate , aspartate , gaba and taurine , were measured in the cortex , striatum , hippocampus , midbrain , and brain stem of acute or chronic ethanol-treated rats , site specific changes were observed for glutamate , glycine , and aspartate . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
21,
26
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
264,
271
]
} |
although separated by geographical barriers , the colombian stocks showed the same isoenzyme profiles in 7 and 8 out of the eleven enzymes analyzed as the brazilian reference zymodemes . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
83,
92
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
131,
138
]
} |
this respiratory impairment is probably due to the presence of so2 and the quality of the hydrocarbons in gasoline exhaust gases . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
63,
66
]
} | {
"id": "C0017110",
"name": "gases",
"pos": [
123,
128
]
} |
aclacinomycin was generally more inhibitory than doxorubicin , 4'-epi-doxorubicin and 4'-epi-tetrahydropyranyl-adriamycin , with both succinate and nad+-linked substrates . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
49,
60
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
86,
87
]
} |
urinary excretion of ag ( i ) determined by solvent extraction and separation by liquid anion exchanger proved very high , after 24-36 h from the casting processes . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
2,
3
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
88,
93
]
} |
in two cases the onset of the symptoms was ascribed to the occupational exposure to glue activators ( containing usually a considerable percentage of chlorinated hydrocarbons as dichloromethane or methilenedichloride ) . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
150,
174
]
} | {
"id": "C0025748",
"name": "dichloromethane",
"pos": [
178,
193
]
} |
injections of physiological and supraphysiological doses of epinephrine ( e ) into cardiac-cannulated eels cause a dose-related increase of plasma dopamine ( da ) and norepinephrine ( ne ) within 3 min . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
60,
71
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
167,
181
]
} |
to investigate directly whether a sodium-potassium-chloride cotransport system is operating in the mammalian thick ascending limb of henle 's loop ( talh ) and in the elasmobranch rectal gland , plasma membrane vesicles were prepared from talh cells isolated from rabbit kidney outer medulla and from rectal glands of squalus acanthias , and chloride uptake was measured by a rapid filtration technique . | NA | {
"id": "C0037494",
"name": "sodium",
"pos": [
34,
40
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
342,
350
]
} |
polyclonal antisera against huhb-beta from h-2 congenic mice on the c57bl/10 ( b10 ) background contained antibodies expressing the hb-2d cri ; | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
11,
19
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
106,
116
]
} |
these antisera , however , contained little if any antibody to the antigenic determinant on huhb-beta recognized by hb-2d . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
6,
14
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
51,
59
]
} |
polyclonal antisera to huhb-beta from the strains a.ca , a.sw , c3h.ol , balb/cbyj , dba/2 and sjl/j contained lower , but nevertheless detectable , amounts of antibody expressing the hb-2d cri . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
11,
19
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
160,
168
]
} |
it would appear , therefore , that hb-2d possesses a cri that is carried by antibodies to various antigenic determinants on huhb . | NA | {
"id": "C0021013",
"name": "cri",
"pos": [
53,
56
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
98,
120
]
} |
a dna restriction fragment length polymorphism in the complement region of the human mhc shows an absolute correlation with polymorphism of complement factor b ( bf ) defined by isoelectric focusing . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
54,
64
]
} | {
"id": "C0033453",
"name": "complement factor",
"pos": [
140,
157
]
} |
two patients ( 18 % ) with dcm and 11 patients ( 100 % ) with icm had episodes of chest pain and the former two had lv regional wall thinning , suggesting the possibility of post-myocarditis cardiomegaly . | NA | {
"id": "C0007193",
"name": "dcm",
"pos": [
27,
30
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
191,
203
]
} |
the degree of asynergy was graded on a four-point scale as dyskinesis = 3 , akinesis = 2 , hypokinesis = 1 , and normokinesis = 0 . | NA | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
59,
69
]
} | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
91,
102
]
} |
cyclic gmp , 8-bromo-cgmp and the phosphodiesterase inhibitors ibmx and theophylline mimic the action of eh in triggering premature ecdysis behavior . | NA | {
"id": "C0000096",
"name": "ibmx",
"pos": [
63,
67
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
72,
84
]
} |
feeding postures , stomach eversions and locomotion of initially inactive animals can be released with very dilute solutions of lactic acid , neutral 2 and 3 carbon amino acids , l isomers of 4 to 6 carbon neutral amino acids , l-arginine , acetylcholine iodide , and several of their analogues . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
165,
176
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
206,
225
]
} |
the lowest behavioral thresholds for the most effective feeding stimuli were 3 x 10 ( -11 ) mol/l for both enantiomers of lactic acid , 10 ( -8 ) mol/l for l-proline and both enantiomers of cysteine and 10 ( -7 ) mol/l for acetylcholine iodide and some of the effective neutral amino acids . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
190,
198
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
270,
289
]
} |
the independence of receptor mechanisms for different substances can be inferred as : l-cysteine controlled responsiveness is not always accompanied by responsiveness to neutral amino acids . | NA | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
86,
96
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
170,
189
]
} |
in studies with synthetic oligodeoxynucleotides homologous to leader rna sequences , only those oligonucleotides containing the inhibitory sequence were able to bind to a gradient fraction containing the 65k protein . | NA | {
"id": "C0028948",
"name": "oligodeoxynucleotides",
"pos": [
26,
47
]
} | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
96,
112
]
} |
the n-terminal domain , which is not completely contained in our cdnas , is basic , contains 42 % serine plus alanine , and includes five copies of a six-amino-acid repeating unit . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
110,
117
]
} | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
154,
164
]
} |
although both e1a gene products localized to the nucleus and stimulated adenovirus gene transcription , these proteins did not directly bind to dna under conditions in which a known dna-binding protein , the human c-myc gene product , bound dna efficiently . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
110,
118
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
182,
201
]
} |
all myristylated src proteins examined lack the initiator methionine , but two mutant src proteins lacking the initiator methionine are not myristylated , indicating that removal of the initiator methionine and myristylation are not obligatorily coupled . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
21,
29
]
} | {
"id": "C1564139",
"name": "mutant",
"pos": [
79,
85
]
} |
tsp elements lack two features common to most other transposable elements : tsp integration does not result in the duplication of host dna , and there are no inverted repeats at their termini , although short inverted repeats are present at a distance from the termini . | NA | {
"id": "C0012868",
"name": "transposable elements",
"pos": [
52,
73
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
135,
138
]
} |
madin-darby canine kidney or primary african green monkey kidney cells infected with influenza a/wsn/33 virus and subsequently labeled with monoclonal antibody to the na and then with a colloidal gold- or ferritin-conjugated second antibody exhibited specific labeling of apical surfaces . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
140,
159
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
232,
240
]
} |
dna sequence determination showed that this dna element is a member of a long interspersed repeated dna family ( line ) that is highly repeated ( greater than 50,000 copies ) and highly transcribed in the rat . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
206,
207
]
} |
since chickens do not have gamma-crystallin genes , the expression of a mouse gamma-crystallin promoter in chicken lens cells suggests that different classes of crystallin genes may be regulated by common lens tissue-specific mechanism ( s ) independent of species . | NA | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
27,
43
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
161,
171
]
} |
although the cells expressed protein p21ha-ras at levels similar to those in hasv-transformed fibroblasts , they continued to require il-3 for growth in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} |
we also showed that the fibroblast tat-1 gene was systematically activated in hepatoma x fibroblast hybrids retaining fibroblast chromosomes 8 in the absence of chromosome 11 but was extinguished in cells retaining both fibroblast chromosomes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
220,
230
]
} |
thus , the tat structural genes of both parental cell types were coordinately regulated in the intertypic hybrids , and the tat phenotype of the cells was determined by the presence or absence of fibroblast tse-1 . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
7,
10
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
196,
206
]
} |
in the period july '83 - august '84 we have used 46 of these catheters in 45 children with malignant disease , 12 with acute myeloid leukaemia , 12 with neuroblastoma , 7 with b cell leukaemia-lymphoma , 6 with rhabdomyosarcomas , 2 with ewing 's sarcoma , 2 with wilms ' tumor and 1 case each of hodgkin 's disease , teratocarcinoma , osteosarcoma and juvenile chronic myeloid leukaemia . | NA | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
238,
254
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
336,
348
]
} |
we present a case of a girl with poland 's syndrome ( absence of pectoral muscle and syndactyly ) associated with moebius syndrome . | NA | {
"id": "C0032357",
"name": "poland 's syndrome",
"pos": [
33,
51
]
} | {
"id": "C0039075",
"name": "syndactyly",
"pos": [
85,
95
]
} |
seizure frequency , seizure type and the associated presence of learning disabilities contribute to the heightened psychiatric risk noted in childhood epilepsy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
0,
7
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
151,
159
]
} |
none of the hepatitis and cirrhotic patients showed increased proportions of band y or h ( or y + h ) , indicating the usefulness of the determination of asialo-afp for the discrimination between benign and malignant liver diseases . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
12,
21
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
217,
231
]
} |
the enzyme complex contains less than 0.15 mumol ubiquinone and 12 mumol phospholipid per mumol enzyme . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
4,
18
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
96,
102
]
} |
using morphologic examination and 3h-tdr uptake , the number of hpc of balb/c mice per 10 ( 5 ) bone marrow cells was 33 and 31 respectively . the linear relation between the number of harvested cells and input cells seen on the 4th and 7th days of culture reflected the growth of hpc in microwells . | NA | {
"id": "C0018956",
"name": "hpc",
"pos": [
64,
67
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} |
for acetylcarnitine synthesis , the km is 0.749 mm carnitine and vmax is 641 pmol x mg protein-1 x minute-1 , respectively ; | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
4,
19
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
51,
60
]
} |
these data show that leukemic stem cells are inhibited by bone marrow fc through cell-to-cell contact or humoral factors derived from fc . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
35,
39
]
} | {
"id": "C0016030",
"name": "fc",
"pos": [
134,
136
]
} |
methylprednisolone and three metabolites , 17,21-dihydroxy-6 alpha-methyl-1,4-pregnadiene-3,11,20-trione , 6 alpha-methyl-17,20 beta,21-trihydroxy-1,4-pregnadiene-3,11-dione , and 6 alpha-methyl-11 beta,17,20 beta,21-tetrahydroxy-1,4-pregnadien-3-one were detected in equine urine after intraarticular administration of methylprednisolone acetate . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
0,
18
]
} | {
"id": "C0600901",
"name": "methylprednisolone acetate",
"pos": [
320,
346
]
} |
synthesis of the alpha , beta-unsaturated analogues of cholic acid , deoxycholic acid , chenodeoxycholic acid , and ursodeoxycholic acid is described . | NA | {
"id": "C0011479",
"name": "deoxycholic",
"pos": [
69,
80
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
88,
109
]
} |
synthesis of the alpha , beta-unsaturated analogues of cholic acid , deoxycholic acid , chenodeoxycholic acid , and ursodeoxycholic acid is described . | NA | {
"id": "C0011479",
"name": "deoxycholic",
"pos": [
69,
80
]
} | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
116,
136
]
} |
alterations of cortico-papillary electrolyte gradient of the kidney can now be evaluated by continuous recording of tissue electrical admittance ( a reciprocal of impedance ) , a variable changing directly with tissue concentration of free ions . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
33,
44
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
240,
244
]
} |
no history was suggestive of hemorrhage , despite a substantial hematoma being evacuated during biopsy procedures in 4 patients . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
29,
39
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
64,
72
]
} |
this can be simply accomplished with readily available equipment by serial monitoring of electrical impedance as a probe is directed to the target because the impedance of hematomas , cysts , and most neoplasms is conspicuously below that of normal brain . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
184,
189
]
} | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
201,
210
]
} |
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