text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
chemically , df essentially consists of nonstarch polysaccharides and lignin , and its major constituents are cellulose , hemicelluose , lignin and pectin . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
110,
119
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
137,
143
]
} |
the sti were recorded immediately after blood withdrawal for measuring cortisol , aldosterone , adrenaline and noradrenaline plasma levels . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
111,
124
]
} |
the difference of adrenaline and noradrenaline plasma levels was statistically highly significant between subjects treated with acth 1-17 and those receiving placebo . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
33,
46
]
} |
all coelenterate photoproteins , including aequorin , halistaurin , obelin and phialidin , have relative molecular masses close to 20 000 , contain an identical functional group , and emit blue light in aqueous solution when a trace of ca2+ is added , in the presence or absence of molecular oxygen . | NA | {
"id": "C0024099",
"name": "photoproteins",
"pos": [
17,
30
]
} | {
"id": "C0001694",
"name": "aequorin",
"pos": [
43,
51
]
} |
chronic latent rumen acidosis ( hyper-and parakeratosis , chronic hyperplastic rumenitis , rumenitis-liver abscess complex , hyperlipodeposition , low milk fat syndrome , atypical ketosis , chronic laminitis , cerebrocortical necrosis , acid-base metabolism ) ; | NA | {
"id": "C0001122",
"name": "acidosis",
"pos": [
21,
29
]
} | {
"id": "C0022638",
"name": "ketosis",
"pos": [
180,
187
]
} |
in dogs , especially phenobarbital and primidone must be regarded as useful drugs for chronic treatment on account of their elimination rate and bioavailability . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
21,
34
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
39,
48
]
} |
phenobarbital and primidone are useful for treatment of clonic-tonic generalized seizures ( grand mal ) in dogs . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
0,
13
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
18,
27
]
} |
since primidone , given in high dosage for longer periods of time , gives rise to liver damage , phenobarbital is regarded as the drug of first choice . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
6,
15
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
97,
110
]
} |
marrow transplantation is being explored for the therapy of patients with lymphoma , hodgkin 's disease , preleukemia , multiple myeloma , hairy cell leukemia , small cell lung cancer , testicular cancer , ovarian cancer and neuroblastoma . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
74,
82
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
85,
103
]
} |
the steroids measured by radioimmunoassay included pregnenolone , 17-hydroxypregnenolone , dehydroepiandrosterone , progesterone , 17-hydroxyprogesterone , androstenedione , testosterone and dihydrotestosterone . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
51,
63
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
66,
88
]
} |
the steroids measured by radioimmunoassay included pregnenolone , 17-hydroxypregnenolone , dehydroepiandrosterone , progesterone , 17-hydroxyprogesterone , androstenedione , testosterone and dihydrotestosterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
116,
128
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
131,
153
]
} |
astrocytoma grades 1 and 2 correspond to the rubric `` '' low-grade astrocytoma '' '' in the english nomenclature , grades 3 and 4 to `` '' high-grade astrocytoma '' '' . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
0,
11
]
} | {
"id": "C0017636",
"name": "",
"pos": [
170,
171
]
} |
all bacteria of the morganella-proteus-providencia group tested produced a brownish pigment on agar containing l-forms of aromatic amino acids , i.e . histidine , phenylalanine , tryptophan , and tyrosine in the presence of iron ions under aerobic conditions . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
122,
142
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
163,
176
]
} |
all bacteria of the morganella-proteus-providencia group tested produced a brownish pigment on agar containing l-forms of aromatic amino acids , i.e . histidine , phenylalanine , tryptophan , and tyrosine in the presence of iron ions under aerobic conditions . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
122,
142
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
179,
189
]
} |
all bacteria of the morganella-proteus-providencia group tested produced a brownish pigment on agar containing l-forms of aromatic amino acids , i.e . histidine , phenylalanine , tryptophan , and tyrosine in the presence of iron ions under aerobic conditions . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
122,
142
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
196,
204
]
} |
in the ouchterlony gel precipitation test , using the water soluble fraction and purified proteins as antigens , antibodies could be detected in rabbit immune sera and in sera of patients with salmonella infections . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
113,
123
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
152,
163
]
} |
controlled clinical studies show that the blood glucose control can be improved and the urinary glucose excretion be diminished by addition of dietary fibre . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
42,
55
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
96,
103
]
} |
the strains represented all possible combinations of the most common patterns of phage type and susceptibility to heavy metals ( cadmium , arsenate and mercury ) and antibiotics . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
114,
126
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
129,
136
]
} |
the strains represented all possible combinations of the most common patterns of phage type and susceptibility to heavy metals ( cadmium , arsenate and mercury ) and antibiotics . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
114,
126
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
152,
159
]
} |
[ duration of the cultivation of cell cultures of chick embryo fibroblasts in the presence of isoprinosine ] . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
33,
37
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} |
we discuss the molecular and thermodynamic basis of the contribution to these ion effects from electrolyte-nucleic acid interactions , and demonstrate that a simple ion exchange formalism , involving the stoichiometric participation of individual ions , is the appropriate basis for interpreting these profound effects at a thermodynamic level . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
95,
106
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
247,
251
]
} |
this paper reviews studies on thermostable proteins from thermophilic bacteria and on mutant proteins of human hemoglobin , tryptophan synthase alpha-subunit of e. coli , t4 phage lysozyme , and phage lambda repressor with respect to the role of the constituting amino acid residues in stabilization of conformation . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
43,
51
]
} | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
86,
101
]
} |
it was shown that the conformation of the a family of dna is rather restricted within a limited range , whereas multiple conformations generally exist in the b family of dna fibers . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
170,
173
]
} |
activation of coagulation factor x by a complex of factors ixa-viiia and prothrombin by a complex of factor xa.va is markedly enhanced in the presence of a negatively-charged phospholipid surface . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
26,
34
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
101,
110
]
} |
as a consequence , an increased number of intrinsic factor x and prothrombinase complexes can be assembled at the platelet surface thus leading to an acceleration of factor xa and thrombin formation . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
52,
60
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
166,
175
]
} |
epirubicin ( epi-dx ) , a new analog of doxorubicin , was administered i.v . once q 3 weeks at the dose of 90 mg/m2 to 20 evaluable patients with non-hodgkin 's lymphomas ( nhl ) . | NA | {
"id": "C0014582",
"name": "epi-dx",
"pos": [
13,
19
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
40,
51
]
} |
the findings suggest that the inhibitory mab bound to different epitopes of the same antigen and that the antigen may either be processed or degraded at about the time of merozoite release and erythrocyte invasion . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
64,
72
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
106,
113
]
} |
it was also observed that strain-specific and cross-reactive hab sometimes reacted with the same antigen , suggesting the existence of multiple antigenic determinants in one electrophoretic peak . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
97,
104
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
144,
166
]
} |
we compared the effects of acyclovir ( acv ) and 9- ( 1,3-dihydroxy-2-propoxymethyl ) guanine ( dhpg ) on murine cytomegalovirus ( mcmv ) replication in lung and salivary gland tissues , the evolution of interstitial pneumonitis in vivo , and mcmv replication in mouse embryo cells in vitro . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
27,
36
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
86,
93
]
} |
we compared the effects of acyclovir ( acv ) and 9- ( 1,3-dihydroxy-2-propoxymethyl ) guanine ( dhpg ) on murine cytomegalovirus ( mcmv ) replication in lung and salivary gland tissues , the evolution of interstitial pneumonitis in vivo , and mcmv replication in mouse embryo cells in vitro . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
27,
36
]
} | {
"id": "C0017066",
"name": "dhpg",
"pos": [
96,
100
]
} |
in vivo , whether administered orally by gastric intubation or in the drinking water , or subcutaneously , dhpg was more effective than acv in reducing mcmv titers in lung or salivary gland tissues . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
107,
111
]
} | {
"id": "C0001367",
"name": "acv",
"pos": [
136,
139
]
} |
precolumn derivatization of pipemidic acid was achieved by a methylation reaction with boron trifluoride in methanol after extraction from plasma with chloroform containing 4 % ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
108,
116
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
177,
184
]
} |
the activities of the purine acyclic nucleoside 9- ( 1,3-dihydroxy-2-propoxymethyl ) guanine ( dhpg ) against two human and five animal strains of cytomegalovirus were compared with those of acyclovir . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
85,
92
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
191,
200
]
} |
the activities of the purine acyclic nucleoside 9- ( 1,3-dihydroxy-2-propoxymethyl ) guanine ( dhpg ) against two human and five animal strains of cytomegalovirus were compared with those of acyclovir . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
95,
99
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
191,
200
]
} |
dhpg was significantly more active than acyclovir against all but one ( mouse cytomegalovirus ) of the strains tested , with 50 % effective doses ranging from 5 to 13 microm , as determined by plaque reduction assays in human embryonic lung ( mrc-5 ) and human embryonic tonsil cells . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
0,
4
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
40,
49
]
} |
both dhpg and acyclovir inhibited virus replication at concentrations considerably lower than those necessary to inhibit cell proliferation . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
5,
9
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
14,
23
]
} |
in animal studies , dhpg was slightly more effective than acyclovir in reducing mouse cytomegalovirus-induced mortality . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
20,
24
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
58,
67
]
} |
when tested in parallel , the reference compounds 5-ethyl-2'-deoxyuridine , 5-iodo-2'-deoxyuridine , acyclovir , and ( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) gave mics of 0.20 , 0.18 , 0.04 , and 0.015 micrograms/ml , respectively . | NA | {
"id": "C0020811",
"name": "5-iodo-2",
"pos": [
76,
84
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
148,
160
]
} |
the interaction rate constant averaged 2.2 x 10 ( -4 ) ( micrograms/ml h ) -1 for interaction of both carbenicillin and ticarcillin with gentamicin and 1.6 x 10 ( -4 ) ( micrograms/ml h ) -1 for interaction of the penicillins with tobramycin . | NA | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
120,
131
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
214,
225
]
} |
in the united states , where gentamicin was the most widely used aminoglycoside , 92 % of the strains were resistant to gentamicin , 81 % were resistant to dibekacin , and 8.8 % were resistant to amikacin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
65,
79
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
120,
130
]
} |
in the far east , dibekacin and kanamycin were widely used in the past and more recently amikacin has been frequently used . | NA | {
"id": "C0012024",
"name": "dibekacin",
"pos": [
18,
27
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
32,
41
]
} |
in the far east , dibekacin and kanamycin were widely used in the past and more recently amikacin has been frequently used . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
32,
41
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
89,
97
]
} |
the in vivo and in vitro susceptibility of plasmodium falciparum to chloroquine was investigated in northern liberia after 20 years of continuous chemosuppression and therapy with 4-aminoquinolines . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
68,
79
]
} | {
"id": "C0002588",
"name": "aminoquinolines",
"pos": [
182,
197
]
} |
in this area of liberia no resistance to chloroquine was found in spite of extensive use of 4-aminoquinolines . | NA | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
41,
52
]
} | {
"id": "C0002588",
"name": "aminoquinolines",
"pos": [
94,
109
]
} |
cells liberated after collagenase digestion were transplanted intramuscularly to see whether they will reconstruct cartilage similarly as it happens after transplantation of fetal chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
180,
192
]
} |
spermidine accumulation was faster in chemostat cultures with high dilution rates than in those with low dilution rates and was slower in bacteria that had been grown for several generations with either putrescine or spermidine , suggesting that the spermidine-uptake system was repressed by exogenous polyamines . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
203,
213
]
} | {
"id": "C0037871",
"name": "system",
"pos": [
268,
274
]
} |
it was found that the short-circuit current ( isc ) and the chloride conductance ( gcl ) in toad skin could be separated experimentally by selective use of synthetic oxytocin ( syntocinon ) or theophylline , and by substituting impermeable anions for chloride . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
240,
246
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
251,
259
]
} |
the parameters are the percentages of thc in cannabinoids and in the dried substance of a plant , as well as the percentage of cannabinoids in the dried substance . | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
38,
41
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
127,
139
]
} |
on the basis of these parameters , the authors have found that a cannabis plant in which the percentage of thc exceeds 50 per cent of the total amount of cannabinoids of the extractable resin and 0.3 per cent of the total amount of dried substance , and in which the amounts of resin and cannabinoids are substantial , has a considerable intoxicant potential and is liable to be used for illicit production of cannabis for abuse . | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
107,
110
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
288,
300
]
} |
on the contrary , a plant with a thc level below 50 per cent of the cannabinoids and 0.3 per cent of the dried substance , in addition to a low level of total cannabinoids , has low intoxicant potential and can be used in industry for the production of oil and rope . | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
33,
36
]
} | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
159,
171
]
} |
the participants reviewed the progress that had been made in the past few months and recognized that who activities related to the control of lav/htlv-iii infections and associated diseases , particularly aids , are likely to increase rapidly during the next few years . | NA | {
"id": "C0019693",
"name": "lav/htlv-iii infections",
"pos": [
142,
165
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
205,
209
]
} |
during the peak of the 1983 encephalitis epidemic , 72 % of cases were diagnosed as japanese encephalitis by mac elisa , compared with only 38 % by hi . | NA | {
"id": "C0014055",
"name": "encephalitis epidemic",
"pos": [
28,
49
]
} | {
"id": "C0014057",
"name": "japanese encephalitis",
"pos": [
84,
105
]
} |
from these results , it is concluded that metoclopramide enhances secretory responses to cholinergic stimulations by peripherally sensitizing the muscarinic receptor-mediated exocrine process and this drug is a weaker antagonist of the dopamine d2 receptors than sulpiride . | NA | {
"id": "C0025853",
"name": "metoclopramide",
"pos": [
42,
56
]
} | {
"id": "C2917388",
"name": "antagonist",
"pos": [
218,
228
]
} |
their dissociation constants ( kis and/or kii ) were 2-methyl histamine ( kis = 1751 mumol/l , s.e . = 163 ) less than 4-methyl histamine ( kis = 3551 mumol/l , s.e . = 414 ) less than dimaprit ( kis = 2931 mumol/l , s.e . = 605 ; kii = 3668 mumol/l , s.e . = 901 ) less than histamine ( kis = 6480 mumol/l , s.e . = 1360 ) . | NA | {
"id": "C0025779",
"name": "methyl histamine",
"pos": [
55,
71
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
276,
285
]
} |
[ the bimzat skeletal activator in the treatment of angle class i , ii and iii malocclusions in the mixed dentition ] . | NA | {
"id": "C0399523",
"name": "angle class i",
"pos": [
52,
65
]
} | {
"id": "C0024636",
"name": "malocclusions",
"pos": [
79,
92
]
} |
in contrast , mutants deficient in production of ptx alone ( bp357 , ld50 = 5 x 10 ( 6 ) ) , ac and hly ( bp348 , ld50 greater than 3 x 10 ( 7 ) ) , or all known toxins and virulence factors ( bp347 , ld50 greater than 3 x 10 ( 7 ) ) were severely impaired in their ability to cause a lethal infection . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
162,
168
]
} | {
"id": "C1136170",
"name": "virulence factors",
"pos": [
173,
190
]
} |
endotoxin protein represents a group of immunobiologically active p polypeptides which are associated with the lipopolysaccharide endotoxin in the outer membrane of gram-negative bacteria . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
111,
129
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
130,
139
]
} |
comparison of endotoxin content of pertussis vaccine acellular fractions , polysaccharide fraction and purified lipopolysaccharide suggested that endotoxin probably plays a role in the induction of resistance . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
112,
130
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
146,
155
]
} |
passive transfer of b. bronchiseptica anti-ac antibody , either in the form of monoclonal antibody or antibody transferred to offspring from female mice previously immunized with immunopurified b. bronchiseptica ac , prevented both death and the development of `` '' atrophic rhinitis '' '' in mice infected by an aerosol of virulent b. bronchiseptica . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
79,
98
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
102,
110
]
} |
the ac of bordetella species differ in molecular weight and , despite sharing at least two common non-overlapping epitopes ( bb05 , bb07 ) , antigenic differences are likely : sera from piglets artificially infected with virulent b. bronchiseptica developed high elisa titers against ac from b. bronchiseptica but low titers against b. pertussis-derived antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
114,
122
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
141,
150
]
} |
such vaccination had a significant protective effect in children aged 1-4 years but not in older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
56,
64
]
} | {
"id": "C1455726",
"name": "older",
"pos": [
91,
96
]
} |
encephalopathy was induced in resistant h-2b mice with b. pertussis and passively administered anti-bsa antiserum , but not with b. pertussis and anti- ( t , g ) -a -- l antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
104,
113
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
170,
178
]
} |
the chemical glycosilation was performed using an oligosaccharide hapten derived from the purified capsular polysaccharide of neisseria meningitidis group c . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
50,
65
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
108,
122
]
} |
by contrast , the main antigenic regions recognized in the native protein pt by specific polyclonal antibodies appeared lost after the coupling procedure involving pt as the carrier protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
66,
73
]
} | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
174,
189
]
} |
in group 2 , the treatment was similar to group 1 but the lincomycin was replaced by 600 mg clindamycin . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
58,
68
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
92,
103
]
} |
the present study , the first comparing three antianaerobic antibiotics and an aminoglycoside in the prophylaxis of infection in colorectal surgery , shows certain clinical and socioeconomic benefits , although not statistically significant to be found in the group 3 program ( gentamycin plus metronidazole ) as compared with the other programs . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
79,
93
]
} | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
278,
288
]
} |
the possibilities of local dissolution of uric acid calculi with na hydrocarbonate , k carbonate and lithium carbonate were examined in vitro . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
73,
82
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
101,
118
]
} |
it appears that bdnf may act as common 'central target-derived ' neurotrophic factor for both placode- and crest-derived sensory neurons , but that within peripheral tissues there are specific neurotrophic factors for each of these two classes of primary sensory neurons . | NA | {
"id": "C0107103",
"name": "bdnf",
"pos": [
16,
20
]
} | {
"id": "C0027754",
"name": "neurotrophic factors",
"pos": [
193,
213
]
} |
it appears that bdnf may act as common 'central target-derived ' neurotrophic factor for both placode- and crest-derived sensory neurons , but that within peripheral tissues there are specific neurotrophic factors for each of these two classes of primary sensory neurons . | NA | {
"id": "C0083735",
"name": "neurotrophic factor",
"pos": [
65,
84
]
} | {
"id": "C0027754",
"name": "neurotrophic factors",
"pos": [
193,
213
]
} |
the early biochemical responses stimulated by the action of mitogens and growth factors on mouse thymocytes and 3t3 fibroblasts are analysed as part of a systematic attempt to define the mitogenic pathways from g0 to s phase in these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
116,
127
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
the rationale for this hypothesis lies in the co-mitogenic action of the ca2+-ionophore , a23187 , and the phorbol ester , 12-o-tetradecanoyl phorbol 13-acetate , which is assumed to activate specifically protein kinase c . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
107,
120
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl",
"pos": [
123,
141
]
} |
the central alpha 2-adrenergic agonists ( alpha-methyldopa , clonidine , and guanabenz ) have little or no clinical effect on gfr and erpf/rbf ; | NA | {
"id": "C2267005",
"name": "central alpha 2-adrenergic",
"pos": [
4,
30
]
} | {
"id": "C0025741",
"name": "alpha-methyldopa",
"pos": [
42,
58
]
} |
the central alpha 2-adrenergic agonists ( alpha-methyldopa , clonidine , and guanabenz ) have little or no clinical effect on gfr and erpf/rbf ; | NA | {
"id": "C2267005",
"name": "central alpha 2-adrenergic",
"pos": [
4,
30
]
} | {
"id": "C0018312",
"name": "guanabenz",
"pos": [
77,
86
]
} |
the production of hydrogen peroxide ( h2o2 ) by polymorphonuclear leukocytes ( pmns ) that are exposed to lambda-carrageenan ( 100 micrograms/ml ) and 12-0-tetradecanoylphorbol-13-acetate ( tpa , 100 ng/ml ) was measured by a colorimetric method . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
27,
35
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
38,
42
]
} |
for confirmation of this , we examined the effects of serum from rabbits of various ages on rabbit fetal skin fibroblasts ( rsf cell ) and human fetal lung fibroblasts ( tig-1 cell ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
176,
180
]
} |
reduced glutathione ( gsh ) , gsh stability and glucose-6-phosphate dehydrogenase ( g6pd ) activity in fractionated red cells decreased with age , while oxidized glutathione ( gssg ) and methemoglobin ( methb ) increased with age . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
22,
25
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
176,
180
]
} |
enzyme activity is significantly lower in cells and extracts at high mean population doublings ( mpd ) as compared to fibroblasts at low mpd . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
42,
47
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
118,
129
]
} |
[ ultrastructure of the unattached wall of the periodontal pocket and the chemotaxis of granulocytic neutrophils in rapidly progressing periodontitis ] . | NA | {
"id": "C0031094",
"name": "periodontal pocket",
"pos": [
47,
65
]
} | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
136,
149
]
} |
it was noted that in the two experiments , one using prenatal d-amphetamine and one prenatal methylmercury exposure , both test batteries were in general agreement , viz. , d-amphetamine was largely negative with no major findings observed and methylmercury was positive with several major findings . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
64,
75
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
173,
186
]
} |
the dopaminergic systems are particularly suitable for examining the hypothesis , since the neural tracts using dopamine have been widely studied ; | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
4,
16
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
112,
120
]
} |
literature is reviewed that supports the hypothesis that drugs affecting dopamine metabolism , when administered during the early development of the dopaminergic tracts , produce persistent changes both in the metabolism of dopamine and in behavior mediated by neural systems which utilize dopamine as a transmitter . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
149,
161
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
290,
298
]
} |
a fatal spongiform encephalopathy of sheep and goats ( scrapie ) shares many characteristics with creutzfeldt-jakob disease ( cjd ) , a similar dementing illness of humans . | NA | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
8,
33
]
} | {
"id": "C0036457",
"name": "scrapie",
"pos": [
55,
62
]
} |
therefore , it was concluded that in pennsylvania there are some 'weak links ' through which scrapie-infected animals could contaminate human food , and that consumption of these foods could perhaps account for spongiform encephalopathy in humans . | NA | {
"id": "C0036457",
"name": "scrapie",
"pos": [
93,
100
]
} | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
211,
236
]
} |
in 32 women with seizures occurring mainly in the premenstrual phase and during bleeding , ( group a ) and in 31 women with epilepsy without this relationship of the seizures to the menstrual cycle ( group b ) the metabolites of adrenocortical hormones ( 17-ketosteroids and 17-hydroxycorticosteroids ) were determined in 24-hour urine . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
124,
132
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
166,
174
]
} |
in 32 women with epileptic seizures related in time to the premenstrual phase ( group a ) and 31 women with seizures unrelated to this phase ( group b ) oestrone oestradiol and oestriol and progesterone metabolites ( alpha and beta-pregnanediol ) were determined in 24-hour urine . | NA | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
17,
35
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
108,
116
]
} |
in 32 women with epileptic seizures related in time to the premenstrual phase ( group a ) and 31 women with seizures unrelated to this phase ( group b ) oestrone oestradiol and oestriol and progesterone metabolites ( alpha and beta-pregnanediol ) were determined in 24-hour urine . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
190,
202
]
} | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
232,
244
]
} |
on the other hand , it may be concluded that progesterone deficiency may have an effect on the appearance of greater readiness to seizures before menstruation in epileptic women . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
130,
138
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
162,
171
]
} |
immediately before using the dialyzer in the same patient the fluid system was rinsed with conditioned water , and the blood system with 21 of sterile distilled water and with 41 of 0.9 % nacl solution . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
103,
108
]
} | {
"id": "C0359299",
"name": "sterile",
"pos": [
143,
150
]
} |
while the pneumonia could have been acquired in the nursery , the presence of chorioamnionitis and mixed infection with group b beta-hemolytic streptococcus suggests that an ascending infection from the birth canal might be another mode of transmission for neonatal adenovirus pneumonia . | NA | {
"id": "C0275524",
"name": "mixed infection",
"pos": [
99,
114
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
184,
193
]
} |
during exercises /control/ and examination on work psychology /experiment/ were investigated the cardiac frequency , blood supply of extremities , peripheral vessel tone , velocity of pulse wave spreading , ekg , pulse variety , skin resistance , excretion of adrenaline , noradrenaline , 11-ocs and other parameters . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
260,
270
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
273,
286
]
} |
[ risk factors and the development of ischemic heart disease during a 6-year observation of male population . v. evaluation of probability of the development of myocardial infarction using risk function calculated for different populations ] . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
19,
22
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
161,
182
]
} |
experiments were performed in order to investigate , at the light- and electron-microscopic levels , the transneuronal transport of wheatgerm agglutinin conjugated with horseradish peroxidase ( wga : hrp ) in the somatosensory system of rats . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
169,
191
]
} | {
"id": "C0078473",
"name": "wga : hrp",
"pos": [
194,
203
]
} |
in one additional animal , wga : hrp was injected in one side , whereas free hrp was injected in the contralateral dcn . | NA | {
"id": "C0078473",
"name": "wga : hrp",
"pos": [
27,
36
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
77,
80
]
} |
radiation response ( as assessed from the cervical lymphnode involvement ) of npc was influenced by tumor burden and histologic type of the tumor , namely the less differentiated tumor responded better than the more differentiated one . | NA | {
"id": "C0027652",
"name": "histologic type of",
"pos": [
117,
135
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
179,
184
]
} |
rapid and accurate assay methods for cholesterol : nadph oxidoreductase ( ec 1.14.13.17 , 7 alpha-hydroxylating ) and 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase ( enzyme not yet registered ) are described . | NA | {
"id": "C0027298",
"name": "nadph oxidoreductase",
"pos": [
51,
71
]
} | {
"id": "C0030016",
"name": "ec",
"pos": [
74,
76
]
} |
the concentration of oxygen or nutrients in the water seems to be without relevance , whereas the most significant variable is temperature , which in our experiments was highest in the sewage and lowest in the drinking water containers . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
48,
53
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
210,
224
]
} |
apart from the known oligodynamic action of some heavy metals the activity of antimony , cobalt , gold , and platinum should be mentioned . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
49,
61
]
} | {
"id": "C0003380",
"name": "antimony",
"pos": [
78,
86
]
} |
apart from the known oligodynamic action of some heavy metals the activity of antimony , cobalt , gold , and platinum should be mentioned . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
49,
61
]
} | {
"id": "C0009148",
"name": "cobalt",
"pos": [
89,
95
]
} |
apart from the known oligodynamic action of some heavy metals the activity of antimony , cobalt , gold , and platinum should be mentioned . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
49,
61
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
98,
102
]
} |
apart from the known oligodynamic action of some heavy metals the activity of antimony , cobalt , gold , and platinum should be mentioned . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
49,
61
]
} | {
"id": "C0032207",
"name": "platinum",
"pos": [
109,
117
]
} |
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