text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these results favor the possibility that the activation of t cells is not dependent upon their ability to bind to anti-id , but rather on their capacity to respond to epitopes of id-anti-id antigen-antibody complexes formed on b cells . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
167,
175
]
} | {
"id": "C0021013",
"name": "id",
"pos": [
187,
189
]
} |
corticosteroid hormone relationships with peripheral organs and tissues depending on the state of the trophic function of the nervous system . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
0,
14
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
15,
22
]
} |
histological analysis of 90 spontaneous primary tumours of the brain observed among 8960 ageing rats ( sprague-dawley-derived ) revealed 55 granular-cell meningiomas , 19 neoplastic reticuloses , 11 neuroglial tumours , 4 pineal tumours , and one pleomorphic , meningeal sarcoma . | NA | {
"id": "C0006118",
"name": "of",
"pos": [
22,
24
]
} | {
"id": "C0031941",
"name": "pineal tumours",
"pos": [
222,
236
]
} |
the single or double oxidation products of oleate , linoleate , arachidonate , and docosahexaenoate were detected with 10 pg sensitivity in oxidized rat retina phospholipids or synthetic phospholipids , by negative ion chemical ionization with specific ion monitoring of carboxylate anions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
27,
30
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
283,
289
]
} |
consecutive action of phospholipase a2 and glutathione peroxidase is required for reduction of phospholipid hydroperoxides and provides a convenient method to determine peroxide values in membranes . | NA | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
108,
122
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
169,
177
]
} |
the purpose of this study was to investigate the ability of selenium-dependent glutathione peroxidase to reduce phospholipid hydroperoxides in membrane bilayers and to develop a method to measure the peroxide content of phospholipids . | NA | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
125,
139
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
200,
208
]
} |
the enzyme assay can be used for convenient determination of peroxide values in phospholipids at the 1 nmole level and free fatty acid hydroperoxides can be distinguished from phospholipid hydroperoxides by omitting phospholipase a2 . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
61,
69
]
} | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
189,
203
]
} |
the accuracy of the enzymatic method was confirmed using an improved colorimetric chemical assay to measure peroxide values of phospholipid hydroperoxides to the same sensitivity . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
108,
116
]
} | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
140,
154
]
} |
the chemical assay was not linear in the presence of high levels of lipid , but at low levels of lipid the peroxide values of phospholipid hydroperoxides measured by both methods agreed to within 1 % . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
107,
115
]
} | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
139,
153
]
} |
the signalling function of ca2+ demands a very low ionic concentration of the cation within heart cells . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
51,
56
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
78,
84
]
} |
the second mechanism is more efficient , since the complexation by soluble proteins is limited by their amount in heart sarcoplasm or within heart organelles , whereas membrane proteins can regulate calcium efficiently , even if present in low amounts , if they 'return ' rapidly in the uncomplexed from after each binding and transport cycle . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
75,
83
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
168,
185
]
} |
however , on further investigation it was found that over the next 2 h the rates of histone protein and dna synthesis recover , in some cases completely to the uninhibited rate , while the synthesis rates of other proteins do not recover . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
92,
99
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
189,
198
]
} |
in the fusiform mutant-infected cells , the localization and myristylation of pp60src were determined and the extent of expression of the extracellular matrix protein fibronectin was examined at both the mrna and protein levels . | NA | {
"id": "C0079323",
"name": "extracellular matrix protein",
"pos": [
138,
166
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
167,
178
]
} |
within all fusiform mutant-transformed cec , pp60src was dramatically absent from the adhesion plaque sites normally seen in cells transformed with wild-type rsv , and these transformed cec all expressed more fibronectin mrna and protein in the extracellular matrix than did the wild-type rsv-transformed cec . | NA | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
209,
220
]
} | {
"id": "C0079323",
"name": "protein",
"pos": [
230,
237
]
} |
a scarce , soluble , conserved protein was identified as the nonphosphorylated precursor of two related 42-kilodalton phosphoproteins that contain phosphotyrosine in mitogen-stimulated but not control fibroblasts . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
31,
38
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
118,
133
]
} |
tryptic fingerprint analysis of [ 35s ] methionine-labeled proteins indicated that the viral fms proteins and the 140-kda bewo cell protein were highly related . | NA | {
"id": "C0042736",
"name": "viral",
"pos": [
87,
92
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
132,
139
]
} |
an acg codon , which replaces the aug codon used to initiate the synthesis of bacteriophage t7 gene 0.3 protein , was shown to function as a low-efficiency initiation codon in a wheat germ cell-free protein-synthesizing system . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
7,
12
]
} | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
156,
172
]
} |
after calcium phosphate-dna transfection , this vector rendered d. melanogaster cells resistant to the aminoglycoside g-418 , a derivative of gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
103,
117
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
142,
152
]
} |
to test the usefulness of this system for introducing nonselected dna into d. melanogaster cells , a gene fusion between the p transposable element and the hsp70 promoter was inserted into the copia-neomycin resistance plasmid . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
66,
69
]
} | {
"id": "C0012868",
"name": "transposable element",
"pos": [
127,
147
]
} |
we also found that the production of several cellular proteins that influence cytomorphology was inhibited in hybrid and nonhybrid cells that expressed ad2 t antigens , and the repression of these cellular proteins correlated with a change in cytomorphology from fibroblastic to spherical . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
45,
53
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
263,
275
]
} |
microinjection of either mutant c6 sv40 dna , which encodes a large t antigen unable to bind specifically to viral regulatory sequences , or deleted viral dna lacking part of the large t antigen coding sequences yielded ratios of l-strand to e-strand rna that were similar to those observed with wild-type sv40 dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
149,
158
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
311,
314
]
} |
polyclonal and monoclonal antibodies with specificity for protein mx ( a karyophilic 75,000-dalton protein induced by interferon [ ifn ] in mouse cells carrying the influenza virus resistance allele mx+ ) detected an ifn-induced 80,000-dalton protein in peripheral blood lymphocytes and in fibroblasts of healthy human donors . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
146,
151
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
290,
301
]
} |
the effect of apamin , a bee venom toxin , on the action potential and the spike after hyperpolarization was studied in bullfrog sympathetic ganglion cells . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
14,
20
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
25,
34
]
} |
teratogen-induced herniation of the occipital lobes ( encephalocele ) in monkey fetuses was repaired by amputation and cranioplasty in utero or postnatally . | NA | {
"id": "C0019270",
"name": "herniation",
"pos": [
18,
28
]
} | {
"id": "C0014065",
"name": "encephalocele",
"pos": [
54,
67
]
} |
serum concentrations of cholesterol , triglycerides , high density lipoprotein-cholesterol ( hdl-c ) , apoproteins ( apo ) a and b were compared in 36 hemodialysis patients and in 20 normal controls . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
24,
35
]
} | {
"id": "C0023822",
"name": "high density",
"pos": [
54,
66
]
} |
our study investigates liver involvement serum parameters in 71 subjects with cholelithiasis and choledocholithiasis , without primary liver diseases . | NA | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
78,
92
]
} | {
"id": "C0701818",
"name": "choledocholithiasis",
"pos": [
97,
116
]
} |
rabbit aortic smooth muscle cells cultured for 14 days in second passage produce significant amounts of protein-bound radioactive nt-methylhistidine when pulsed with radiolabelled histidine . | NA | {
"id": "C0025780",
"name": "methylhistidine",
"pos": [
133,
148
]
} | {
"id": "C0019602",
"name": "histidine",
"pos": [
180,
189
]
} |
radioactive nt-methylhistidine to histidine ratio reaches a maximum approximately 8 days following the 1-day [ 14c ] histidine pulse . | NA | {
"id": "C0025780",
"name": "methylhistidine",
"pos": [
15,
30
]
} | {
"id": "C0019602",
"name": "histidine",
"pos": [
117,
126
]
} |
the data presented in this communication indicate that methods to evaluate nt-methylhistidine synthesis and disappearance in cultures are feasible when radiolabelled histidine is employed . | NA | {
"id": "C0025780",
"name": "methylhistidine",
"pos": [
78,
93
]
} | {
"id": "C0019602",
"name": "histidine",
"pos": [
166,
175
]
} |
[ studies on the granulocyte and/or macrophage colony-stimulating factor ( csf ) in the urine and a medium conditioned in vitro by tumor cells from a patient with csf-producing lung cancer ] . | NA | {
"id": "C0079784",
"name": "macrophage colony-stimulating factor",
"pos": [
36,
72
]
} | {
"id": "C0009392",
"name": "csf",
"pos": [
163,
166
]
} |
lipophilic weak electrolytes , such as propionate , rapidly penetrate the cell membranes in their undissociated acid from but not as negatively charged ions . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
16,
28
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
152,
156
]
} |
these findings were compared with the effect of cadmium and other heavy metals on embryos , larvae and adults of several amphibian , fish and mammalian species . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
48,
55
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
66,
78
]
} |
most importantly , these monoclonal antibodies were also not able to induce dna synthesis in quiescent human fibroblasts , not even after cross-linking of the egf receptors by a second antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
25,
46
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
185,
193
]
} |
diagnosis can be made in cases of sinus tachycardia , supra ventricular tachycardia with and without aberrancy and ventricular tachycardia with dissociation . | NA | {
"id": "C0039239",
"name": "sinus tachycardia",
"pos": [
34,
51
]
} | {
"id": "C0039240",
"name": "supra ventricular",
"pos": [
54,
71
]
} |
the wall motion was assessed visually and classified as normal motion , hypokinesis , akinesis and dyskinesis . | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
72,
83
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
99,
109
]
} |
all patients had advanced asynergy ( severe hypokinesis , akinesis or dyskinesis ) except one with subendocardial infarction . | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
44,
55
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
70,
80
]
} |
however , the addition of albumin ( 2 g/dl ) was protective , suggesting that the protein impeded adsorption of salivary progesterone by the plastic container . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
26,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
82,
89
]
} |
ten different fluorescein-conjugated lectins of various known sugar specificities were used to study cell surface glycoconjugates of normal and regenerating rat skeletal muscle . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
62,
67
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
114,
129
]
} |
after diltiazem , supraventricular tachycardia could not be reinitiated in only 2 patients and the tachycardia initiating window was not significantly reduced ( 56 +/- 26 to 41 +/- 33 msec ) . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
18,
46
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
99,
110
]
} |
to study the mechanism of catcholamine-induced positive inotropy , sarcolemmal membrane proteins were isolated from freeze-clamped rabbit hearts perfused with [ 32p ] and proteins were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
79,
96
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
171,
179
]
} |
in 106 clinical isolates of multiresistant klebsiella pneumoniae strains , we found that aminoglycoside-resistance was due mostly to two adenylating enzymes : aad ( 2 '' '' ) ( 56.6 % ) , that modifies gentamicin , kanamycin , tobramycin and sissomicin , and aad ( 3 '' '' ) 9 ( 56.6 % + 19.8 % ) that modifies streptomycin and spectinomycin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
89,
103
]
} | {
"id": "C0017436",
"name": "gentamici",
"pos": [
202,
211
]
} |
in 106 clinical isolates of multiresistant klebsiella pneumoniae strains , we found that aminoglycoside-resistance was due mostly to two adenylating enzymes : aad ( 2 '' '' ) ( 56.6 % ) , that modifies gentamicin , kanamycin , tobramycin and sissomicin , and aad ( 3 '' '' ) 9 ( 56.6 % + 19.8 % ) that modifies streptomycin and spectinomycin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
89,
103
]
} | {
"id": "C0001268",
"name": "spectinomyc",
"pos": [
328,
339
]
} |
in 106 clinical isolates of multiresistant klebsiella pneumoniae strains , we found that aminoglycoside-resistance was due mostly to two adenylating enzymes : aad ( 2 '' '' ) ( 56.6 % ) , that modifies gentamicin , kanamycin , tobramycin and sissomicin , and aad ( 3 '' '' ) 9 ( 56.6 % + 19.8 % ) that modifies streptomycin and spectinomycin . | NA | {
"id": "C0017436",
"name": "gentamici",
"pos": [
202,
211
]
} | {
"id": "C0037209",
"name": "sissomici",
"pos": [
242,
251
]
} |
examination of the cation contents of the cells by atomic absorption spectrophotometry showed early and rapid increase of ca2+ during intoxication with concomitant changes in na+ , k+ and mg2+ that reduced the ion concentration gradients between inside and outside of the cell present before toxin treatment . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
19,
25
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
224,
227
]
} |
differences in the experimental animals were observed in the free amino acid levels of serum ( decreased lysine , arginine , and ornithine ) and liver ( decreased ornithine ) , in blood chemistries ( decreased levels of ammonia n2 , uric acid , cholesterol , protein , albumin , alkaline phosphatase , ldh and sgot ) and in hematologic findings ( leukocytopenia and thrombocytopenia after a morning feeding ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
259,
266
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
269,
276
]
} |
on the contrary the employ of retinoids , synthetic derivatives of vitamin a , brings to excellent results . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
30,
39
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
67,
76
]
} |
university of l'aquila -- university of rome ) we have treated a group of women ( double-blind trial ) affected by breast dysplasia , with vitamin a and e association to evaluate the effectiveness of retinoids and alpha-tocopherol in reducing or resolving clinical palpable breast findings ( with pain , tension , nodularity and instrumental patterns ) . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
139,
148
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
200,
209
]
} |
eight patients had parenchymal abnormalities found by ultrasonic scanning : five had multiple abnormalities whereas three had a single abnormal area . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
31,
44
]
} | {
"id": "C0000772",
"name": "multiple abnormalities",
"pos": [
85,
107
]
} |
it was demonstrated that the total antigenicity of this tumour consisted of multiple antigens , all of which were independent , tumour-specific and expressed simultaneously on the same tumour cell . | NA | {
"id": "C0003335",
"name": "antigenicity",
"pos": [
35,
47
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
85,
93
]
} |
finally , using tumour-specific monoclonal antibodies against the syngeneic tumour , investigation into the molecular nature of these tumour antigens indicated that some of these antigens represent novel class i major-histocompatibility-complex molecules . | NA | {
"id": "C0003335",
"name": "tumour",
"pos": [
16,
22
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
179,
187
]
} |
variant-specific long-term cytolytic t lymphocyte clones were isolated and used for the immunoselection of secondary antigen-loss variants that could then be analysed for the presence of previously undefined residual variant antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
117,
124
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
225,
247
]
} |
it is applicable in the evaluation of specific diseases including cardiac allograft rejection , myocarditis , anthracycline cardiotoxicity , and infiltrative cardiomyopathies . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
96,
107
]
} | {
"id": "C0878544",
"name": "cardiomyopathies",
"pos": [
158,
174
]
} |
glutamine content was greatly reduced in all brain regions , while glutamic acid and proline contents were elevated . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
0,
9
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
67,
80
]
} |
excessive excretion of beta-alanine and of 3-hydroxypropionic , r- and s-3-aminoisobutyric , r- and s-3-hydroxyisobutyric and s-2- ( hydroxymethyl ) butyric acids probably due to a defect in the metabolism of the corresponding malonic semialdehydes . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
10,
19
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
195,
205
]
} |
diagnosis of classical morquio 's disease : n-acetylgalactosamine 6-sulphate sulphatase activity in cultured fibroblasts , leukocytes , amniotic cells and chorionic villi . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
145,
150
]
} |
the mean activities of normal fibroblasts , leukocytes and amniotic cells were 8.43 , 2.59 and 3.14 nmol h-1 mg protein-1 , respectively . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
68,
73
]
} |
fibroblasts from five patients with classical morquio 's disease ( mucopolysaccharidosis iva ; mpsiva ) and one patient with neonatal multiple sulphatase deficiency displayed activities of less than 5 % of control mean . | NA | {
"id": "C0026707",
"name": "morquio 's disease",
"pos": [
46,
64
]
} | {
"id": "C0026703",
"name": "mucopolysaccharidosis",
"pos": [
67,
88
]
} |
the oculo-cerebro-renal syndrome described by lowe is a catastrophic disease in children characterized by progressive eye , central nervous system and kidney degeneration . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
24,
32
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
69,
76
]
} |
we determined procollagen production in cultured skin fibroblasts originating from patients with lowe 's syndrome as well as normal individuals after incubation of cells with [ 14c ] proline for 1,4 and 20 h . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
54,
65
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
125,
131
]
} |
in aspartylglycosaminuria ( agu ) , a lysosomal storage disorder of glycoprotein degradation , there are some abnormalities in collagen and proteoglycan metabolism . | NA | {
"id": "C0268225",
"name": "aspartylglycosaminuria",
"pos": [
3,
25
]
} | {
"id": "C0085078",
"name": "lysosomal storage disorder",
"pos": [
38,
64
]
} |
however , the patients had normal serum copper levels , and the concentrations of zinc and copper in cultured fibroblasts did not differ from those of control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
159,
164
]
} |
peripheral neuroblastic tumors ( pnt ) , including neuroblastomas , pheochromocytomas , ganglioneuromas , and paragangliomas , have been reported in association with congenital heart disease ( chd ) . | NA | {
"id": "C0031511",
"name": "pheochromocytomas",
"pos": [
68,
85
]
} | {
"id": "C0030421",
"name": "paragangliomas",
"pos": [
110,
124
]
} |
the case records of patients presenting with metastases from an unknown primary cancer ( mup ) have been reviewed . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
45,
55
]
} | {
"id": "C0027667",
"name": "unknown primary",
"pos": [
64,
79
]
} |
administration of 5 % sodium l-ascorbate ( sa ) , the sodium ion form of aa significantly promoted urinary bladder carcinogenesis , whereas administration of 5 % aa did not . | NA | {
"id": "C0887557",
"name": "sodium",
"pos": [
22,
28
]
} | {
"id": "C0003968",
"name": "aa",
"pos": [
162,
164
]
} |
the urine of rats given sa but not aa was characterized by an apparent elevation of ph , an increase of sodium ion concentration , and increases in the urinary content of total aa and its metabolite , dehydroascorbic acid . | NA | {
"id": "C0887557",
"name": "sa",
"pos": [
24,
26
]
} | {
"id": "C0003968",
"name": "aa",
"pos": [
177,
179
]
} |
the urine of rats given sa but not aa was characterized by an apparent elevation of ph , an increase of sodium ion concentration , and increases in the urinary content of total aa and its metabolite , dehydroascorbic acid . | NA | {
"id": "C0003968",
"name": "aa",
"pos": [
35,
37
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
201,
221
]
} |
utilizing this mnng plus high salt diet as the initiation stage of a two-step protocol , it was also established that subsequent dietary administration of nacl ( 10 % of the diet ) for 32 weeks tended to enhance tumor development in the glandular stomach . | NA | {
"id": "C0206136",
"name": "salt diet",
"pos": [
30,
39
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
155,
159
]
} |
the synthetic retinoid , 13-cis retinoic acid , inhibits both colon and lung cancer in animal models ; | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
14,
22
]
} | {
"id": "C0022265",
"name": "13-cis retinoic acid",
"pos": [
25,
45
]
} |
the formation of these iq-type mutagens was shown to occur when model systems of creatin ( in ) e , reducing monosaccharides , and certain amino acids were heated at 128 degrees c for 2 hr . | NA | {
"id": "C0010286",
"name": "creatin",
"pos": [
81,
88
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
139,
150
]
} |
the inactivation effects of the mutagen on single-stranded dna of bacteriophage m13 m p1 , double-stranded form of this bacteriophage ( replicative form-rf ) and on the complex of rna-polymerase with rf dna have been compared . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
43,
62
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
203,
206
]
} |
the mol mass of a component of both toxins is identical but in contrast to choleragen the component of lt-enterotoxin is not subject to proteolysis . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
36,
42
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
106,
117
]
} |
the genetic analysis has confirmed existence of plasmid cointegrates in the transformant cells , which carry three yeast genes , bacterial dna fragment and 2 micrometers dna fragment , coding for replicative functions . | NA | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
129,
142
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
170,
173
]
} |
it is firmly established that phosphatidylinositol and possibly polyphosphoinositides are involved with events at the synapse during impulse propagation , but their precise role in molecular terms is not clear . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
30,
50
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
64,
85
]
} |
the effects of heavy metals ( in particular pb , cd , cr , mn and hg ) on pituitary , thyroid , adrenal gland , pancreas and gonads are reviewed . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
15,
27
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
66,
68
]
} |
after a review of the research performed about the occupational hypothesis of malignant lymphoma 's etiology , a personal interview schedule was used to study the occupational exposure among 89 patients with hodgkin 's disease and non-hodgkin 's lymphoma and 89 referents . | NA | {
"id": "C0024299",
"name": "malignant lymphoma 's",
"pos": [
78,
99
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
208,
226
]
} |
after a review of the research performed about the occupational hypothesis of malignant lymphoma 's etiology , a personal interview schedule was used to study the occupational exposure among 89 patients with hodgkin 's disease and non-hodgkin 's lymphoma and 89 referents . | NA | {
"id": "C0024299",
"name": "malignant lymphoma 's",
"pos": [
78,
99
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
231,
254
]
} |
the agricultural workers only presented a significant relative risk for the malignant lymphoma as a whole and for non-hodgkin 's lymphoma , but not for hodgkin 's disease ; | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
76,
94
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
114,
137
]
} |
the agricultural workers only presented a significant relative risk for the malignant lymphoma as a whole and for non-hodgkin 's lymphoma , but not for hodgkin 's disease ; | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
76,
94
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
152,
170
]
} |
the specific activity of the fluff was 3.3 milk lipoprotein lipase units/mg of protein , which was significantly higher than the casein and serum fractions in pooled milk . | NA | {
"id": "C0026138",
"name": "milk",
"pos": [
43,
47
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
129,
135
]
} |
in contrast , postprandial levels of branched chain amino acids ( bcaa ) were significantly reduced : total bcaa ( valine , leucine , and isoleucine ) 120 mins following a standard test meal fell from 717 +/- 71 mumol/l before therapy to 600 +/- 90 mumol/l after 3 months ' therapy ( p less than 0.01 ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
52,
63
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
108,
112
]
} |
in contrast , postprandial levels of branched chain amino acids ( bcaa ) were significantly reduced : total bcaa ( valine , leucine , and isoleucine ) 120 mins following a standard test meal fell from 717 +/- 71 mumol/l before therapy to 600 +/- 90 mumol/l after 3 months ' therapy ( p less than 0.01 ) . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
66,
70
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
115,
121
]
} |
in contrast , postprandial levels of branched chain amino acids ( bcaa ) were significantly reduced : total bcaa ( valine , leucine , and isoleucine ) 120 mins following a standard test meal fell from 717 +/- 71 mumol/l before therapy to 600 +/- 90 mumol/l after 3 months ' therapy ( p less than 0.01 ) . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
66,
70
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
141,
148
]
} |
in contrast , postprandial levels of branched chain amino acids ( bcaa ) were significantly reduced : total bcaa ( valine , leucine , and isoleucine ) 120 mins following a standard test meal fell from 717 +/- 71 mumol/l before therapy to 600 +/- 90 mumol/l after 3 months ' therapy ( p less than 0.01 ) . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
66,
70
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
138,
148
]
} |
serial measurements of plasma volume and transcapillary escape rate of albumin ( tera ) using 125i-labelled albumin , serum colloid osmotic pressure ( cop ) using a membrane colloid osmometer , packed cell volume ( pcv ) , and serum proteins , showed that oedema was associated with an increased plasma volume and tera , while serum albumin and total protein concentration and serum cop were reduced . | NA | {
"id": "C0001924",
"name": "tera",
"pos": [
81,
85
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
377,
382
]
} |
a reduction in daily insulin dose abolished hypoglycaemia and resulted in weight loss , natriuresis , diuresis , a reduction in plasma volume and tera , and an increase in serum albumin , total protein , and cop . | NA | {
"id": "C0001924",
"name": "tera",
"pos": [
146,
150
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
172,
185
]
} |
the efficacy of the sulphonylurea gliclazide was assessed in 229 non-insulin-dependent diabetics attending u.k. outpatient diabetic clinics . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
20,
33
]
} | {
"id": "C0017631",
"name": "gliclazide",
"pos": [
34,
44
]
} |
the in vitro activity of cefotetan , a new cephamycin antibiotic , was tested against 296 bacterial strains , recently clinically isolated , by measuring the minimum inhibitory concentrations . | NA | {
"id": "C0007555",
"name": "cefotetan",
"pos": [
25,
34
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
43,
53
]
} |
histamine does not interfere with the glucose metabolizing action of insulin , but markedly enhances the utilization of glucose , to judge from a significant decrease in the pas-positive ( hexose ) component of histamine-exposed tetrahymena pyriformis gl cells . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
38,
45
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
189,
195
]
} |
in four of these , marked focal emphasis of tonic fast activity in actual seizure recordings provided the basis for local ablative surgery in the expectation of removal of the epileptic focus . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
74,
81
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
176,
185
]
} |
it would seem , therefore , that though the focal structural lesion and the seizures probably stemmed from the same source , surgery to the lesion did not effect the removal of an 'epileptic focus ' . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
76,
84
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
181,
190
]
} |
the study demonstrated powerfully that there were no statistically significant or clinically relevant differences between the meals in post-prandial glucose peak elevation , or in incremental area under the blood glucose curve to 120 mins . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
149,
156
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
207,
220
]
} |
clinical and cytogenetic findings from 16 prepubertal males with the fragile x syndrome ( x-linked mental retardation with postpubertal macro-orchidism and fragile site at xq27/8 , or martin-bell syndrome ) and from their families are reported . | NA | {
"id": "C1136249",
"name": "x-linked mental retardation",
"pos": [
90,
117
]
} | {
"id": "C0016667",
"name": "martin-bell syndrome",
"pos": [
184,
204
]
} |
the williams elfin facies syndrome ( williams-beuren syndrome ) is a disorder characterized by a typical facies , supravalvular aortic stenosis and mental retardation . | NA | {
"id": "C0175702",
"name": "williams-beuren syndrome",
"pos": [
37,
61
]
} | {
"id": "C0003499",
"name": "supravalvular aortic stenosis",
"pos": [
114,
143
]
} |
annual and daily levels of the two major oxides of nitrogen ( nox ) , nitric oxide ( no ) and nitrogen dioxide ( no2 ) are still rising in the atmosphere of the urban environment and in close proximity to automobile and airport traffic . | NA | {
"id": "C0028167",
"name": "of",
"pos": [
24,
26
]
} | {
"id": "C0028160",
"name": "nitrogen dioxide",
"pos": [
94,
110
]
} |
there is a correlation between body weight or obesity and blood pressure in the population , and most hypertensive patients are overweight . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
31,
42
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
128,
138
]
} |
this data base was developed for a series of complex mixtures including emissions from coke ovens , roofing tar pots , cigarette smoke and automotive engines . | NA | {
"id": "C1258022",
"name": "complex mixtures",
"pos": [
45,
61
]
} | {
"id": "C0039315",
"name": "tar",
"pos": [
108,
111
]
} |
the conclusion is drawn that rats eat at a rate just required to prevent hypoglycemia under ad-lib conditions and that after food deprivation they transiently increase this rate to correct the fall in blood glucose and to reestablish the required supply of glucose to tissues . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
198,
214
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
257,
264
]
} |
there are no other clinical clues to the presence of myocarditis in those patients presenting with cardiomyopathy or ventricular arrhythmia . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
53,
64
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
99,
113
]
} |
myocardial bioptic findings in correlation with tl-201 imaging and hemodynamic parameters in patients with latent cardiomyopathies suspected of having myocarditis . | NA | {
"id": "C0878544",
"name": "cardiomyopathies",
"pos": [
114,
130
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
151,
162
]
} |
myocarditis and cardiomyopathy were diagnosed in 36 dogs from 11 litters , and myoendocarditis and restrictive cardiomyopathy were diagnosed in 51 cats . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
0,
11
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
111,
125
]
} |
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