text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
myocarditis and cardiomyopathy were diagnosed in 36 dogs from 11 litters , and myoendocarditis and restrictive cardiomyopathy were diagnosed in 51 cats . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
16,
30
]
} | {
"id": "C0007196",
"name": "restrictive cardiomyopathy",
"pos": [
99,
125
]
} |
it has been emphasized that clear concepts and a uniform approach are essential in diagnosing myocarditis , not only to achieve precise diagnosis , accurately monitoring the response to therapy , but also in helping to establish the pathogenetic pathways for certain forms of cardiomyopathy . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
94,
105
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
276,
290
]
} |
false-positive clinical diagnoses probably most commonly result from a failure to recognize other disorders , such as cardiomyopathy and myocardial infarction , that may mimic myocarditis . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
118,
132
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
176,
187
]
} |
allergic granulomatosis and vasculitis ( the churg-strauss syndrome ) , which gives rise to granulomas involving the myocardium , and eosinophilic ( hypersensitivity ) myocarditis usually respond rapidly to treatment with steroids . | NA | {
"id": "C0008728",
"name": "churg-strauss syndrome",
"pos": [
45,
67
]
} | {
"id": "C0018188",
"name": "granulomas",
"pos": [
92,
102
]
} |
in general , adverse drug reactions manifest themselves as myocarditis ( toxic or hypersensitivity ) , cardiomyopathy with chamber dilatation , or restrictive disease . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
59,
70
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
103,
117
]
} |
clinically detectable myocarditis is rare in children , and the preponderance of dilated cardiomyopathy is in patients above the age of 30 years , possibly because there is a long latent period between the initial infection and the development of frank cardiomyopathy . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
22,
33
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
253,
267
]
} |
patients with extensive myocardial infarctions , complicated by cardiogenic shock , or in end-stage heart failure , and who are candidates for heart replacement by transplantation or by a mechanical device , would benefit from such circulatory assistance . | NA | {
"id": "C0027051",
"name": "myocardial infarctions",
"pos": [
24,
46
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
64,
81
]
} |
nearly all tumors so designated in the past are malignant lymphomas , small-cell variants of medullary carcinomas , or poorly differentiated ( insular ) carcinomas . | NA | {
"id": "C0262584",
"name": "small-cell",
"pos": [
70,
80
]
} | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
153,
163
]
} |
it also includes lymphomatoid papulosis as well as nonlymphoid cutaneous infiltrates such as myeloid leukemias , histiocytosis x , malignant histiocytosis , regressing atypical histiocytosis , and neuroendocrine ( merkel ) cell carcinoma . | NA | {
"id": "C0019621",
"name": "histiocytosis x",
"pos": [
113,
128
]
} | {
"id": "C0019618",
"name": "histiocytosis",
"pos": [
177,
190
]
} |
they are a heterogeneous lot with some similarities to carcinoids , small cell carcinomas , and large cell or adenocarcinomas . | NA | {
"id": "C0007095",
"name": "carcinoids",
"pos": [
55,
65
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
110,
125
]
} |
the intravascular bronchioloalveolar tumor and the sclerosing hemangioma of the lung : misnomers of pulmonary neoplasia . | NA | {
"id": "C1334455",
"name": "the sclerosing hemangioma of",
"pos": [
47,
75
]
} | {
"id": "C0024121",
"name": "pulmonary neoplasia",
"pos": [
100,
119
]
} |
malignant lymphomas originating primarily in the mediastinum consist predominantly of hodgkin 's disease of the nodular sclerosis type , lymphoblastic lymphomas , and large cell non-hodgkin 's lymphomas of diffuse growth pattern ( dhl ) . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
0,
19
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
178,
202
]
} |
the development of various pharmacologic probes that inhibit the ras at different and specific points in the renin-angiotensin cascade has facilitated the elucidation of the role of angiotensin ii in renovascular hypertension . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
115,
126
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
182,
196
]
} |
if beta-lactam drugs are needed for treatment of penicillin allergic patients , acute desensitization appears to be an acceptably safe procedure for avoiding anaphylaxis . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
3,
14
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
49,
59
]
} |
the distinct features of the eosinophil include their content of large crystalloid granules which contain a number of unique basic proteins , and their capacity to selectively generate the srs-a , sulphidopeptide leukotrienes . | NA | {
"id": "C0038091",
"name": "srs-a",
"pos": [
189,
194
]
} | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
213,
225
]
} |
simultaneously the plasma anti-iia-activity of heparin after 4 hours and the anti-xa-activity after 2 and 4 hours increased significantly ( p less than or equal to 0.05 ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
47,
54
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
77,
84
]
} |
effects of the heart lung machine on factors of complement and prekallikrein-kallikrein system using fragmin as anticoagulant in an in vitro study . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
63,
76
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
77,
87
]
} |
the leukopenia and granulocytopenia in the latter is much less pronounced and probably reflects the phenomenon `` '' frustrated phagocytosis '' '' . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
4,
14
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
19,
35
]
} |
the dosage of regular insulin injected at meal times by a penshaped device ( novo pen ) was calculated in dependence of the carbohydrate content of the ingested meal , daytime , difference of actual and target blood glucose , 4 daily glucose levels of the last 2 or 4 days and physical activity . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
210,
223
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
234,
241
]
} |
the term transforming growth factor ( tgf ) has been applied to peptides that have the ability to confer the transformed phenotype on untransformed fibroblastic indicator cells in vitro . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
148,
160
]
} |
all the strains were susceptible to kanamycin , amikacin , cefotaxime , cefuroxime , chloramphenicol , fosfomycin , mezlocillin , nitrofurantoin , piperacillin , piperimidic acid , polymyxin b , sisomycin and tobramycin , and resistant to cephalotoxin , ampicillin and trimethoprim-sulfamethoxazole . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
36,
45
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
48,
56
]
} |
all the strains were susceptible to kanamycin , amikacin , cefotaxime , cefuroxime , chloramphenicol , fosfomycin , mezlocillin , nitrofurantoin , piperacillin , piperimidic acid , polymyxin b , sisomycin and tobramycin , and resistant to cephalotoxin , ampicillin and trimethoprim-sulfamethoxazole . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
59,
69
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
72,
82
]
} |
all the strains were susceptible to kanamycin , amikacin , cefotaxime , cefuroxime , chloramphenicol , fosfomycin , mezlocillin , nitrofurantoin , piperacillin , piperimidic acid , polymyxin b , sisomycin and tobramycin , and resistant to cephalotoxin , ampicillin and trimethoprim-sulfamethoxazole . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
116,
127
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
254,
264
]
} |
all the strains were susceptible to kanamycin , amikacin , cefotaxime , cefuroxime , chloramphenicol , fosfomycin , mezlocillin , nitrofurantoin , piperacillin , piperimidic acid , polymyxin b , sisomycin and tobramycin , and resistant to cephalotoxin , ampicillin and trimethoprim-sulfamethoxazole . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
147,
159
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
254,
264
]
} |
2 ) antibodies : multivalent antisera anti-bovine , anti-ovine , anti-porcine and anti-equine , were obtained by immunization of rabbits with an emulsion of 1 vol of whole serum and 1 vol of freund complete adjuvant ; | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
29,
37
]
} |
a tanker truck carrying anhydrous ammonia ( nh3 ) fell off a freeway , releasing a dense cloud of nh3 gas , killing several people . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
34,
41
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
102,
105
]
} |
death from asphyxia due to substitution of air by methane gas may occur in coal mine by gas outburst . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
0,
5
]
} | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
11,
19
]
} |
the activities of the liver microsomal enzymes nadph-cytochrome reductase ( ec 1.6.2.4 ) , flavoprotein-linked monooxygenase ( ec 1.14.14.1 ) and o-demethylase were significantly greater in animals fed on 120 and 200 g protein/kg diet compared with those fed on 30 g protein/kg diet . | NA | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
91,
103
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
267,
274
]
} |
a level of dietary protein of less than 50 g/kg impaired the fermentation of wheat-bran fibre , whereas a level higher than 100 g protein/kg did not further increase the degree of fermentation of the fibre . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
11,
26
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
130,
137
]
} |
the cell-wall material of white lupin ( lupinus albus l. ) cotyledon is characterized by low contents of cellulose ( 47 g/kg ) and lignin ( 17 g/kg ) and a high content of pectic substances ( 710 g/kg ) . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
105,
114
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
131,
137
]
} |
dna polymerases have a preference for the addition of purines , particularly adenine , opposite non-instructional sites . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
54,
61
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
77,
84
]
} |
the variation was not gender-specific and covariate analyses taking account of brain weight and age detected no differences in splenial width or area between males and females in childhood . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
22,
28
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
170,
175
]
} |
apart from the incomplete antibodies against external antigens of smooth brucella abortus strains detected in long-term stimulated cattle , non-agglutinating antibodies with specificity for deeper antigens of the smooth bacteria were evidenced . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
54,
62
]
} | {
"id": "C0003321",
"name": "antigens",
"pos": [
197,
205
]
} |
several unique and controversial lesions have been selected for discussion , including ( 1 ) necrotizing sialometaplasia , a benign salivary gland disease easily mistaken for malignancy ; | NA | {
"id": "C0037033",
"name": "necrotizing sialometaplasia",
"pos": [
93,
120
]
} | {
"id": "C0036093",
"name": "salivary gland disease",
"pos": [
132,
154
]
} |
an electron microscopic survey of monomorphic adenomas , adenoid cystic carcinomas , and mucoepidermoid carcinomas reveals some having a tumor cell component with structural modifications and localization similar to the modified myoepithelial cells in pleomorphic adenomas and the adenocarcinomas noted above . | NA | {
"id": "C0010606",
"name": "adenoid cystic",
"pos": [
57,
71
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
281,
296
]
} |
an electron microscopic survey of monomorphic adenomas , adenoid cystic carcinomas , and mucoepidermoid carcinomas reveals some having a tumor cell component with structural modifications and localization similar to the modified myoepithelial cells in pleomorphic adenomas and the adenocarcinomas noted above . | NA | {
"id": "C0206694",
"name": "mucoepidermoid carcinomas",
"pos": [
89,
114
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
281,
296
]
} |
the osmotica mannitol and peg 6000 ( polyethylene glycol ) lengthen the circadian period from 27.9 hr ( control ) to about 29.5 hr . | NA | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
26,
34
]
} | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
37,
56
]
} |
night-time pineal levels of tryptophan , 5-hydroxytryptophan , serotonin , n-acetylserotonin , melatonin , 5-hydroxyindoleacetic acid and the activities of the two enzymes n-acetyltransferase and hydroxyindole-o-methyltransferase involved in the cyclic production of melatonin were determined in male albino rats and syrian hamsters that were implanted with thyroxine or thyroidectomized two weeks earlier . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
28,
38
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
41,
60
]
} |
especially in nonfunctional or noncoding dna , this could cause a general increase in dna amounts . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
90,
91
]
} |
the crystallin genes , which display a lens-specific expression pattern , were studied in these blind mammals and in related species with normal eyes by hybridizing their genomic dnas with probes obtained from cdna clones for alpha a- , alpha b- , and beta bp-crystallins from calf and gamma 3-crystallin from the rat . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
4,
14
]
} | {
"id": "C0005203",
"name": "beta",
"pos": [
252,
256
]
} |
the expression of the crystallins at the protein level was tested by using antiserum specific for alpha-crystallin in immunofluorescence reactions on lens sections of mole and mole rat eyes and by using antisera against the beta- and gamma-crystallins on sections of the mole eye . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
22,
33
]
} | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
98,
114
]
} |
the expression of the crystallins at the protein level was tested by using antiserum specific for alpha-crystallin in immunofluorescence reactions on lens sections of mole and mole rat eyes and by using antisera against the beta- and gamma-crystallins on sections of the mole eye . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
22,
33
]
} | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
234,
251
]
} |
previous reports have interpreted hybridization between snake satellite dna and dna clones from a variety of distant taxonomic groups as evidence for evolutionary conservation , which implies common ancestry ( homology ) and/or convergence ( analogy ) to produce the cross-hybridizing sequences . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
62,
75
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
80,
83
]
} |
factors found to be associated with greater compliance with follow-up appointments were ( 1 ) the appointment being made to the er rather than to the clinic , ( 2 ) the child being less than 18 months of age , ( 3 ) the patient having private insurance , and ( 4 ) an initial er diagnosis of trauma , seizure , or burn . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
292,
298
]
} | {
"id": "C0006434",
"name": "burn",
"pos": [
314,
318
]
} |
a further one-to-one comparison of the upstream regions of several yeast ribosomal protein genes revealed extensive additional sequence homologies that are suggested to be involved in the coordinate control of ribosomal protein gene expression in yeast . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
83,
90
]
} | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
210,
227
]
} |
the dna sequence responsible for the 5 ' end of the his3 mrnas remain in the class two gene fusions but this did not preclude the initiation of transcription at bacterial dna sequences . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
4,
7
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
161,
174
]
} |
the pattern of mrna initiation at bacterial dna suggests that dna sequences at , or adjacent to , the site of transcription initiation are involved in the determination of the sites of initiation , and perhaps the frequency at which initiation occurs . | NA | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
34,
47
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} |
further investigation showed an absence of the corpus callosum and probably herniation of an encephalocele into the third ventricle . | NA | {
"id": "C0019270",
"name": "herniation",
"pos": [
76,
86
]
} | {
"id": "C0014065",
"name": "encephalocele",
"pos": [
93,
106
]
} |
we have conducted a detailed study of 108 qa-2+ neurospora transformants which were obtained by use of circular plasmid dnas and various linear dnas . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
103,
111
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
144,
148
]
} |
transformation with linear plasmid dnas and dna fragments carrying the qa-2 gene resulted in a demonstrable increase in transformation frequency beyond that achieved with circular plasmid dnas , but did not permit precise targeting to the resident locus . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
35,
38
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
171,
179
]
} |
covalently closed circular dna was efficiently converted to the open ( relaxed ) form upon exposure to dissolved rose bengal plus light in a time-dependent reaction , showing that this system was capable of causing dna strand breakage at ph 7.8 . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
18,
30
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
215,
218
]
} |
we conclude that , although singlet oxygen seems to play a role in dna strand breakage by rose bengal plus light , singlet oxygen per se is very inefficient if not completely incapable of causing dna strand breakage . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
196,
199
]
} |
using a novel high performance liquid chromatography ( hplc ) determination of ascorbic acid and dehydroascorbic acid , we have measured the relative amounts of ascorbate and dehydroascorbate in 20 normal controls and in paired sera and synovial fluid from 13 patients with rheumatoid arthritis ( ra ) . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
79,
92
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
97,
117
]
} |
the stimulative effect of 8 anthracyclines ( the parent compounds daunorubicin and doxorubicin and 6 structurally closely related anthracyclines ) on the production of thiobarbituric acid ( tba ) -reactive material was investigated in liver microsomes . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
66,
78
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
83,
94
]
} |
in essence , most photocutaneous porphyrias occurring in childhood will relate to congenital erythropoietic porphyria or protoporphyria . | NA | {
"id": "C0032708",
"name": "porphyrias",
"pos": [
33,
43
]
} | {
"id": "C0162530",
"name": "congenital erythropoietic",
"pos": [
82,
107
]
} |
in protoporphyria , the dermatologic problem is less severe and the dermatologist should be aware that a subset of patients could develop active liver disease that may lead to fatal cirrhosis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
145,
158
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
182,
191
]
} |
anti-inflammatory properties of liposteroid , a lipid emulsion containing dexamethasone palmitate in the particles , were investigated in comparison with those of water-soluble dexamethasone phosphate . | NA | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
74,
87
]
} | {
"id": "C0770565",
"name": "dexamethasone phosphate",
"pos": [
177,
200
]
} |
distribution of dexamethasone to the inflammatory lesion in rats with adjuvant arthritis was markedly higher in the liposteroid group than in the dexamethasone phosphate group : 1.5 times higher in 2-6 hours and approximately twice in 24 h . | NA | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
16,
29
]
} | {
"id": "C0770565",
"name": "dexamethasone",
"pos": [
146,
159
]
} |
the relative order of potency was found to be , iris : 1-epinephrine much greater than d-epinephrine congruent to 1-norepinephrine congruent to dl-alpha-methyl-norepinephrine greater than dl-alpha-methyl-epinephrine greater than d-norepinephrine ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} | {
"id": "C0205758",
"name": "dl",
"pos": [
188,
190
]
} |
the relative order of potency was found to be , iris : 1-epinephrine much greater than d-epinephrine congruent to 1-norepinephrine congruent to dl-alpha-methyl-norepinephrine greater than dl-alpha-methyl-epinephrine greater than d-norepinephrine ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
231,
245
]
} |
the relative order of potency was found to be , iris : 1-epinephrine much greater than d-epinephrine congruent to 1-norepinephrine congruent to dl-alpha-methyl-norepinephrine greater than dl-alpha-methyl-epinephrine greater than d-norepinephrine ; | NA | {
"id": "C0025805",
"name": "alpha-methyl-norepinephrine",
"pos": [
147,
174
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
231,
245
]
} |
intraocular pressure ( iop ) : l-epinephrine greater than dl-alpha-methyl-epinephrine greater than d-epinephrine greater than dl-alpha-methyl-norepinephrine greater than d-norepinephrine congruent to 1-norepinephrine . | NA | {
"id": "C0205758",
"name": "dl",
"pos": [
58,
60
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
205,
216
]
} |
intraocular pressure ( iop ) : l-epinephrine greater than dl-alpha-methyl-epinephrine greater than d-epinephrine greater than dl-alpha-methyl-norepinephrine greater than d-norepinephrine congruent to 1-norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
33,
44
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
202,
216
]
} |
intraocular pressure ( iop ) : l-epinephrine greater than dl-alpha-methyl-epinephrine greater than d-epinephrine greater than dl-alpha-methyl-norepinephrine greater than d-norepinephrine congruent to 1-norepinephrine . | NA | {
"id": "C0025805",
"name": "alpha-methyl-norepinephrine",
"pos": [
129,
156
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
202,
216
]
} |
both acute and chronic effects on intraocular pressure of 11-hydroxy- delta 9-tetrahydrocannabinol ( 11-oh-delta 9-thc ; a metabolite of delta 9-thc ) and 1-nantradol ( a synthetic cannabinoid ) have been examined in the cat . | NA | {
"id": "C0039663",
"name": "thc",
"pos": [
115,
118
]
} | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
181,
192
]
} |
the mixed co-cultures of n-13a tumor cells and several tissue explants of newborn wistar rats show selective adhesivity between tumoral and hepatic epithelial cells , but not with fibroblast-like cells of nervous tissue , kidney or diaphragm . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
180,
190
]
} |
immunofluorescence on polymorphonuclear cells ( pmn ) of patients with felty syndrome ( fs ) revealed increased amounts of igg , iga , and igm bound to the pmn surface compared with pmn of patients with rheumatoid arthritis alone . | NA | {
"id": "C0015773",
"name": "felty",
"pos": [
71,
76
]
} | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
203,
223
]
} |
from these results it is concluded that a chondroid metaplasia not only leads to a matrix comparable to cartilage but also contains cells that gain further characteristics of original chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
184,
196
]
} |
consequently the action of radicals is different from autoxidation processes and the modified residues in the abnormal hemoglobins are not involved in the action of superoxide ion on hb . | NA | {
"id": "C0019047",
"name": "abnormal",
"pos": [
110,
118
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
183,
185
]
} |
[ exercise tests in ischemic heart disease . ii . use of the exercise test in the diagnosis and clinical evaluation of ischemic heart disease ] . | NA | {
"id": "C0151744",
"name": "ischemic heart disease",
"pos": [
20,
42
]
} | {
"id": "C0018799",
"name": "of",
"pos": [
116,
118
]
} |
[ effect of naloxone on corticotropin ( acth ) and somatotropin ( hgh ) secretion in patients with chronic renal failure ] . | NA | {
"id": "C0037663",
"name": "somatotropin",
"pos": [
51,
63
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
66,
69
]
} |
multiple opioid peptides and the modulation of pain : immunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
9,
24
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
86,
95
]
} |
multiple opioid peptides and the modulation of pain : immunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
9,
24
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
100,
110
]
} |
retrograde transport of lectin-hrp conjugate ( wga-hrp ) was used to examine the anatomical organization of long ascending propriospinal neurons ( lapns ) projecting to the cervical enlargement ( c5-t1 ) and to the upper part of the cervical cord ( c3-4 ) in cats . | NA | {
"id": "C0019941",
"name": "hrp",
"pos": [
31,
34
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
47,
54
]
} |
we studied the clinical efficacy of 4-channel cassette recording of the eeg for 105 children being evaluated for possible seizures or further clarification of a known seizure disorder . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
122,
130
]
} | {
"id": "C0014544",
"name": "seizure disorder",
"pos": [
167,
183
]
} |
this decrease in reactivity occurs parallel or even prior to the cleavage of lps into free lipid a and the polysaccharide moiety . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
77,
80
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
91,
98
]
} |
results of the naio4 oxidation , methylation and proton magnetic resonance spectroscopy of the native and dephosphorylated preparations , in combination with data of the analysis of oligosaccharides obtained from partial hydrolysis of polysaccharide , led to the most likely structure of the repeating units of the acidic polysaccharide chain , -- -- 4 ) n-acetylglucosaminyl- ( alpha 1 -- -- 3 ) rhamnosyl ( alpha 1 -- -- 3 ) galactosyl ( alpha 1 -- -- 4 ) [ sn-glycerol 1-phospho-2 ] rhamnosyl ( alpha 1 -- -- . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
182,
198
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
322,
336
]
} |
diolein increases the affinity of the enzyme for both cofactors and can be replaced by the tumour-promoting phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
108,
115
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
141,
148
]
} |
the accumulation of cell wall hydroxyproline was associated with rapid transient increases in the extractable activities of proline 2-oxoglutarate dioxygenase and a protein arabinosyl transferase . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
30,
44
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
124,
131
]
} |
the peroxisomal aldehyde dehydrogenase is active with different aliphatic and aromatic aldehydes , except for formaldehyde and glyceraldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
87,
96
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
127,
141
]
} |
hmgi is present in proliferating fibroblasts and embryos but is present in very low levels in rat liver , a non-dividing tissue , supporting the notion that hmgi is required for proliferating cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
the binding of oligonucleotides and polynucleotides to the pf1 dna-binding protein was followed by fluorescence spectral shift and lifetime measurements , which gave an anomalous value for the stoichiometry of binding . | NA | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
15,
31
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
36,
51
]
} |
comparison of k1 values for oligonucleotide binding leads to an estimated ( single-site ) intrinsic binding constant kint approximately equal to 3 x 10 ( 4 ) m-1 and a cooperativity parameter omega approximately equal to 100 , in agreement with the apparent binding constant kapp approximately equal to 3 x 10 ( 6 ) m-1 for polynucleotides . | NA | {
"id": "C0028953",
"name": "oligonucleotide",
"pos": [
28,
43
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
324,
339
]
} |
the results suggest that the protein dimers bind cooperatively by lateral association along the dna and that occupation of only one of the two dna-binding sites of the protein dimers is sufficient to stabilize the nucleoprotein complexes . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
29,
36
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
214,
227
]
} |
from the sequence a molecular mass of 24749 da results for the precursor protein and of 21556 da for the mature protein . | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
63,
80
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
112,
119
]
} |
the amino acid composition data of type a ( 8-6 ) and delta toxins was similar , but type a ( 8-6 ) and type a enterotoxins showed less similarity . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
60,
66
]
} | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
111,
123
]
} |
on the basis of proton nmr spectroscopic data and isolation of n-acetylglucosamine 4-phosphate from acid hydrolysates , the poly ( glcnac-1-p ) was shown to be a polymer in which n-acetylglucosamine 1-phosphate units are joined at c-4 of the glucosamine residues . | NA | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
65,
82
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
242,
253
]
} |
comparison of the amino acid sequence with other phosphofructokinases showed that this enzyme is related to the bacillus stearothermophilus and rabbit muscle enzymes , but is different from the second , minor phosphofructokinase found in e. coli . | NA | {
"id": "C0162449",
"name": "phosphofructokinases",
"pos": [
49,
69
]
} | {
"id": "C0031651",
"name": "phosphofructokinase",
"pos": [
209,
228
]
} |
molecular forms of sphingomyelinase and non-specific phosphodiesterases in epstein-barr virus-transformed lymphoid cell lines from niemann-pick disease types a and b . | NA | {
"id": "C0037903",
"name": "sphingomyelinase",
"pos": [
19,
35
]
} | {
"id": "C0031640",
"name": "phosphodiesterases",
"pos": [
53,
71
]
} |
molecular forms of sphingomyelinase and phosphodiesterases from lymphocytes- and epstein-barr virus-transformed lymphoid cell lines were separated by preparative electrofocusing in granulated gels . | NA | {
"id": "C0037903",
"name": "sphingomyelinase",
"pos": [
19,
35
]
} | {
"id": "C0031640",
"name": "phosphodiesterases",
"pos": [
40,
58
]
} |
in either type of cell derived from normal individuals , sphingomyelinase focused as a single peak ( pi = 5.60 +/- 0.1 ) while phosphodiesterases hydrolyzing bis ( 4-methylumbelliferyl ) phosphate and bis ( 4-methylumbelliferyl ) diphosphate separated into seven and three molecular forms respectively ; | NA | {
"id": "C0037903",
"name": "sphingomyelinase",
"pos": [
57,
73
]
} | {
"id": "C0031640",
"name": "phosphodiesterases",
"pos": [
127,
145
]
} |
the protein peak , which in normal cells contained the three activities , had phosphodiesterase but no sphingomyelinase activity in the niemann-pick cells . | NA | {
"id": "C0031640",
"name": "phosphodiesterase",
"pos": [
78,
95
]
} | {
"id": "C0037903",
"name": "sphingomyelinase",
"pos": [
103,
119
]
} |
these data suggest that in lymphoid cell lines , which are a useful model for studies of niemann-pick disease , sphingomyelinase and phosphodiesterases are subject to separate genetic coding and that the latter activities are not a reliable measure for diagnosing niemann-pick disease . | NA | {
"id": "C0037903",
"name": "sphingomyelinase",
"pos": [
112,
128
]
} | {
"id": "C0031640",
"name": "phosphodiesterases",
"pos": [
133,
151
]
} |
by addition of sodium bicarbonate to the incubation mixture l- [ 3-13c ] malate was detected among the excretion products , while the ethanol : succinate ratio of 2.0 in the absence of bicarbonate changed to a ratio of 0.6 in the presence of the latter . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
15,
33
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
185,
196
]
} |
the transport systems required na+ , with the possible exception of the basic amino acid lysine , and were inhibited by n-ethylmaleimide or 3,3',4',5-tetrachlorosalicylanilide . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
72,
77
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
89,
95
]
} |
injections of cyclic amp ( camp ) and 8-br-camp into paramecium and external application of isobutylmethylxanthine ( ibmx ) , an inhibitor of camp breakdown , to these cells increased the frequency of ciliary beating and hyperpolarized the membrane potential . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
14,
24
]
} | {
"id": "C0000661",
"name": "8-br-camp",
"pos": [
38,
47
]
} |
in order to explore a role for vinculin in the formation of the adhesion plaques and of the actin bundles , we have studied and compared the development of these two cellular structures during the spreading of trypsinized and replated chicken embryonic fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular structures",
"pos": [
166,
185
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
253,
264
]
} |
the two largest polypeptides ( bands 1 and 2 ) , i.e . desmoplakins i and ii , are similar in their amino acid composition , confirming our previous immunological and biochemical data , and display a relatively high glycine content . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
100,
110
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
216,
223
]
} |
the luminal contents , including dissociated ligands , other soluble proteins and inclusion vesicles ( containing some membrane proteins ) , would target to lysosomes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
69,
77
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
119,
136
]
} |
the cholesterol : cholesterol ester ratio of the vldl fraction was 8.8:1 and of the hdl fraction 1:1.4 . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
4,
15
]
} | {
"id": "C0023826",
"name": "cholesterol",
"pos": [
18,
29
]
} |
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