text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these results suggest that vitamin d3 is in equilibrium with the lipoprotein surface , and the hepatic uptake of vitamin d is a surface phenomenon independent of lipoprotein metabolism . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
65,
76
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
177,
178
]
} |
these doubly reactive colonies were restricted to the same ia epitope when stimulated with self-pec alone or when stimulated with self-pec in the presence of the relevant exogenous antigen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
62,
69
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
181,
188
]
} |
further study revealed that allogeneic peritoneal cells rich in macrophages or glass-adherent spleen cells enriched for dendritic cells are not stronger stimulators than allogeneic adherent cell-depleted spleen cells and semi-allogeneic thymocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
226,
236
]
} |
flow cytofluorometric analysis of the strain distribution of the molecules defined by the mab revealed that two of the antibodies ( i-22 and iii-5 ) were directed against nonpolymorphic determinants of thy-1 , whereas v-8 mab reacted only with thy-1.2+ lymphocytes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
119,
129
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
222,
225
]
} |
we found that fusaric acid treatment resulted in a rapid decline of adrenal epinephrine ( e ) and norepinephrine ( ne ) and an increase of adrenal dopamine ( da ) ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
76,
87
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
98,
112
]
} |
although the pd2 values for pindolol ( 8.4-9.2 ) and ( - ) -isoprenaline ( iso , 8.4-8.7 ) fell within the same range in these preparations , the maximum responses to pindolol were less than 15 % of those to the catecholamine . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
60,
72
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
212,
225
]
} |
as with sv40 virion-transformed fibroblasts , psv ori -- transformed cells entered a crisis phase , from which about one-fourth of the original clones from a-t and normal fibroblasts recovered . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
69,
74
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
171,
182
]
} |
the antiserum inhibited adhesion of f9 and pys-2 cells not only to plastic dishes but also to those coated with plasma fibronectin , laminin , and plant lectins such as concanavalin a ( cona ) . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
147,
160
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
169,
183
]
} |
when nuclear proteins from oocytes of different amphibian species were examined with these antibodies it was found that the mr values of n1/n2 proteins were considerably different in different species , ranging from mr 110 000 to 190 000 . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
5,
21
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
143,
151
]
} |
sympatho-adrenal reactivity , as assessed by plasma noradrenaline and adrenaline responses , to an orthostatic test and exercise was normal in asthmatic subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
52,
65
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
the disruption of the normal histoarchitecture , the shift in the normal proportions of cells and in cells of different degrees of maturity , and probably , a block imposed on precursor cell maturation , account to a large extent for the well-known failure of immune responses commonly associated with trypanosome infections . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
176,
190
]
} |
an antigen epitope was identified from the excretory-secretory products of trichinella spiralis first-stage larvae using monoclonal antibodies , and the glycoprotein antigens bearing this epitope ( ts.49 and ts.53 ) were isolated from the crude excretory-secretory preparation by affinity chromatography . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
3,
10
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
188,
195
]
} |
this indicated that the exogenous lipid is inserted into lipid core of the membrane rather than adsorbed at the cell surface . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
34,
39
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
57,
62
]
} |
whereas protein synthesis and membrane permeability were affected by the viruses , and virus antigens detectable by pooled human serum were synthesized , the bacterial toxin and cytotoxic csf did not induce any new proteins or antigens , although the cytotoxic csf reduced cellular protein synthesis levels and caused an increase in the permeability of the cell membranes . | NA | {
"id": "C0003342",
"name": "virus antigens",
"pos": [
87,
101
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
227,
235
]
} |
the associations contained albumin , transferrin , immunoglobulins and group-specific proteins situated on the electrophoregram between transferrin and albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
86,
94
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
152,
159
]
} |
the b875-beta-polypeptide contained 48 amino acid residues with alanine and phenylalanine as respective n- and c-termini ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
39,
49
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
82,
89
]
} |
the results indicate that hu has a preference for binding to rna and single-stranded dna over double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
69,
88
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
94,
113
]
} |
guanylyl imidodiphosphate is ineffective at mimicking the gtp effect and inhibits the action of gtp added subsequently . | NA | {
"id": "C0018366",
"name": "guanylyl imidodiphosphate",
"pos": [
0,
25
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
96,
99
]
} |
dna stretches containing such sequences can potentially form a s1 nuclease sensitive slippage ( staggered loop ) structure , which might serve as a locally unstacked intermediate in the b- to z-dna conformational transition . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0043442",
"name": "z-dna",
"pos": [
192,
197
]
} |
preincubation of intact fetal brain neurons in culture with the phorbol ester tpa ( 12-o-tetradecanoyl phorbol-13-acetate ) in the presence of calcium , resulted in the enhancement of the depolarization-induced , ca2+-dependent neurotransmitter release by the cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
64,
77
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol-13-acetate",
"pos": [
84,
121
]
} |
ribosomal proteins participating in intersubunit rna-protein contacts ( directly interacting with rna of the opposite subunit ) were determined by means of ultraviolet-induced cross-links in pre- and post-translocated ribosomal complexes , as well as in the free 70 s ribosome ( tight couple ) of e. coli . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
0,
18
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
53,
60
]
} |
several lines of evidence , which showed that striatal levels of [ met5 ] enkephalin ( me ) increase after the nigrostriatal dopaminergic pathway was interrupted by hemitransection or direct administration of 6-hydroxydopamine to the substantia nigra , or after repeated injections of either reserpine or haloperidol , suggest that dopamine ( da ) plays an important role in regulating the metabolism of me-containing neurons in the striatum . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
125,
137
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
332,
340
]
} |
the fact that endogenous ovulation did not occur in hmg patients who had hcg withheld or in 3 of the 11 ufsh patients who had preovulatory levels of estradiol and follicles greater than 15 mm may imply that these similarly derived gonadotropins in some instances block endogenous ovulation . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
73,
76
]
} | {
"id": "C0018061",
"name": "gonadotropins",
"pos": [
231,
244
]
} |
tl alone resulted in significant increases in the serum concentrations of progesterone , 17-hydroxyprogesterone , 17-hydroxypregnenolone , dehydroepiandrosterone , androstenedione , and the sulfate conjugates of pregnenolone , 17-hydroxypregnenolone and testosterone ( t ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
74,
86
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
89,
111
]
} |
tl alone resulted in significant increases in the serum concentrations of progesterone , 17-hydroxyprogesterone , 17-hydroxypregnenolone , dehydroepiandrosterone , androstenedione , and the sulfate conjugates of pregnenolone , 17-hydroxypregnenolone and testosterone ( t ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
124,
136
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
227,
249
]
} |
fourteen women with ovulatory menstrual cycles were treated with a superactive agonistic analog of gonadotropin-releasing hormone ( 6-d- [ 2-naphthyl ] -alanyl ) -gnrh ( nafarelin ) . | NA | {
"id": "C0023610",
"name": "gnrh",
"pos": [
163,
167
]
} | {
"id": "C0064906",
"name": "nafarelin",
"pos": [
170,
179
]
} |
these results suggest that spermine binding to oligo- and polynucleotides is dependent on the particular nucleotide combination involved and that spermine may therefore be able to act selectively within cells . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
47,
52
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
58,
73
]
} |
these results suggest that spermine binding to oligo- and polynucleotides is dependent on the particular nucleotide combination involved and that spermine may therefore be able to act selectively within cells . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
58,
73
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
105,
115
]
} |
the possibility of direct gonadal effects of gnrh in the newborn and immature rat testis was studied by two approaches : the presence of specific high-affinity receptors for a gnrh agonist analogue ( buserelin ) was studied in animals between the ages of 1 and 60 days ; | NA | {
"id": "C0023610",
"name": "gnrh",
"pos": [
45,
49
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
200,
209
]
} |
these are fluorescent dextrans with average molecular weights of approximately 11 x 10 ( 3 ) , and with one or more fluorophore molecules covalently coupled to each dextran chain . | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
22,
30
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
165,
172
]
} |
to determine if these maternal parameters are related to fetal growth in normal pregnancy , we have examined relationships of lipoprotein lipids , apoproteins , hormones , fuels , clinical chemistries , and maternal weight at 36 wk gestation to infant birth weight , birth weight ratio ( birth weight corrected for gestational age ) , birth length , and head circumference in a cohort of pregnant women attending a prepaid health plan , group health cooperative of puget sound . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
216,
222
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
288,
300
]
} |
results show that the birth weight and/or birth weight ratio are weakly positively associated with maternal very-low-density lipoprotein ( vldl ) triglyceride and statistically significantly positively associated with apoprotein a-i , placental lactogen , estradiol , bilirubin , and maternal prepregnancy weight and pregnancy weight gain . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
22,
34
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
327,
333
]
} |
the influence of two new 1-desoxynojirimycin derivatives , bay m 1099 and bay o 1248 , on rat small intestinal disaccharidases ( sucrase , maltase , isomaltase , glucoamylase , lactase , trehalase ) and alkaline phosphatase activity has been investigated in vitro . | NA | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
111,
126
]
} | {
"id": "C0038634",
"name": "sucrase",
"pos": [
129,
136
]
} |
the influence of two new 1-desoxynojirimycin derivatives , bay m 1099 and bay o 1248 , on rat small intestinal disaccharidases ( sucrase , maltase , isomaltase , glucoamylase , lactase , trehalase ) and alkaline phosphatase activity has been investigated in vitro . | NA | {
"id": "C0012610",
"name": "disaccharidases",
"pos": [
111,
126
]
} | {
"id": "C0040814",
"name": "trehalase",
"pos": [
187,
196
]
} |
thus , our findings suggest that increased polyol pathway activity may be related to the pathogenesis of diabetic neuropathy and erythrocyte sorbitol concentrations may prove a useful indicator for the presence of diabetic complications . | NA | {
"id": "C0011882",
"name": "diabetic neuropathy",
"pos": [
105,
124
]
} | {
"id": "C0342257",
"name": "diabetic complications",
"pos": [
214,
236
]
} |
when compared with normal callus , tumor callus contained reduced levels of both superoxide dismutase and peroxidase , and a reduced number of isozymes of both enzymes . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
143,
151
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
160,
167
]
} |
as judged by the number of isozymes of both superoxide dismutase and peroxidase in each tissue , the following conclusions are warranted : first , tobacco copper/zinc superoxide dismutases and peroxidases are encoded in several duplicated loci which are regulated independently . | NA | {
"id": "C0027021",
"name": "peroxidase",
"pos": [
69,
79
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
193,
204
]
} |
since bcpn is a carboxylic acid , it forms an ester with 9-anthryldiazomethane ( adam ) , which is a fluorescent labeling agent highly sensitive to carboxylic acids . | NA | {
"id": "C0014898",
"name": "ester",
"pos": [
46,
51
]
} | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
148,
164
]
} |
in order to better understand the carcinogenic process , a comparative study was undertaken of the association of nitrosamine-derived radioactivity with nuclear and mitochondrial dna isolated from tumor-susceptible and non-tumor-susceptible tissues of two strains of mice with different susceptibilities to tumor induction by dimethylnitrosamine ( dmn ) or diethylnitrosamine ( den ) . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
114,
125
]
} | {
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
326,
345
]
} |
in order to better understand the carcinogenic process , a comparative study was undertaken of the association of nitrosamine-derived radioactivity with nuclear and mitochondrial dna isolated from tumor-susceptible and non-tumor-susceptible tissues of two strains of mice with different susceptibilities to tumor induction by dimethylnitrosamine ( dmn ) or diethylnitrosamine ( den ) . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
114,
125
]
} | {
"id": "C0012200",
"name": "diethylnitrosamine",
"pos": [
357,
375
]
} |
they included : cellular hypertrophy , contraction bands , interstitial fibrosis , fibroblastic infiltrate , perinuclear , cellular and or interstitial edema . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
83,
95
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
123,
131
]
} |
in assessing the humoral immunoregulatory status in patients with inflammatory bowel disease , we found that the antibody production by the b cells that spontaneously secrete tetanus-specific immunoglobulin g in vitro , and which occur in the circulation 7 days postimmunization , was highly variable and below normal in the majority of crohn 's disease and ulcerative colitis patients . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
66,
92
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
337,
353
]
} |
we have also demonstrated the presence of carnitine acetyltransferase in intestinal mucosa and have shown that the intestine forms significant amounts of acetylcarnitine from exogenous carnitine . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
154,
169
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
185,
194
]
} |
in thalamus with hypothalamus region the highest activity of ( na k ) atpase and the lowest activity of ( ca mg ) atpase occurred . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
70,
76
]
} | {
"id": "C0001477",
"name": "ca mg ) atpase",
"pos": [
106,
120
]
} |
haloperidol ( 10 ( -6 ) m ) , a dopaminergic receptor blocker , did not block the cardiovascular effects of daa and da . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
32,
44
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
116,
118
]
} |
the temporal arrangement of these increases suggested that ecdysteroids , i.e. , 20-hydroxyecdysone , may elicit the increase in ca activity which contributes to the second increase in the jh titer during the latter part of the instar . | NA | {
"id": "C0058915",
"name": "ecdysteroids",
"pos": [
59,
71
]
} | {
"id": "C0013495",
"name": "20-hydroxyecdysone",
"pos": [
81,
99
]
} |
regulation of the ca by 20-hydroxyecdysone was investigated in vitro by assessing the effect of this ecdysteroid on jh i and iii synthesis by ca incubated either as a complex with the brain-corpora cardiaca or as isolated glands . | NA | {
"id": "C0013495",
"name": "20-hydroxyecdysone",
"pos": [
24,
42
]
} | {
"id": "C0058915",
"name": "ecdysteroid",
"pos": [
101,
112
]
} |
a fragment of cauliflower mosaic virus ( camv ) dna , containing delta 3 , one of the three discontinuity sequences , was cloned in various ways into camv dna deleted for the delta 3 sequence . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
155,
158
]
} |
in addition to the fibroblastic characteristics described by previous authors , the cells were found to contain sublemmal filaments classifiable as myofilaments , as typically present in myofibroblasts . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
19,
31
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
84,
89
]
} |
the effect of low dose infusions of somatostatin on meal stimulated gastric acid secretion was studied in eight healthy volunteers by intragastric titration after a peptone test meal with radioimmunoassay control of the plasma concentrations of somatostatin and the pancreatic hormones glucagon and insulin . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
36,
48
]
} | {
"id": "C0030292",
"name": "pancreatic hormones",
"pos": [
266,
285
]
} |
the dry haemoglobin-sucrose system was treated under different conditions of temperature ( up to 85 degrees c ) , time of storage ( up to 6 years ) and residual moisture ( less than 0.1-7.5 % h2o ) , in order to reveal the main features of the hitherto unclear mechanisms of both spontaneous methaemoglobin formation and of the stabilizing effect of sucrose . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
8,
19
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
292,
306
]
} |
serum native fractions of lipoproteins were isolated and mainly high density lipoproteins ( hdl ) and very low density lipoproteins ( vldl ) were shown to have an unspecific inhibitory activity directed on colony stimulating factor ( csf ) action . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
26,
38
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
102,
118
]
} |
methionine is a sulfur-containing essential amino acid and there are optic isomers of l- and d-type . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
0,
10
]
} | {
"id": "C0002525",
"name": "essential amino acid",
"pos": [
34,
54
]
} |
there are following possibilities as regards the relation between the two : first , haphazard association of cardiomyopathy with myocarditis ; | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
109,
123
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
129,
140
]
} |
some gastrointestinal hormones ( cholecystokinin , caerulein , secretin and tetragastrin ) injected intraperitoneally promoted the growth of subcutaneously transplanted tumor . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
5,
30
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
33,
48
]
} |
some gastrointestinal hormones ( cholecystokinin , caerulein , secretin and tetragastrin ) injected intraperitoneally promoted the growth of subcutaneously transplanted tumor . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
5,
30
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
63,
71
]
} |
chloride is the major inorganic anion in bile but its mechanism of passage from blood to bile is uncertain . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
0,
8
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
32,
37
]
} |
the absence of antibody to double-stranded dna in patients with liver disease suggests that there may be a true immunologic distinction between systemic lupus erythematosus and chronic active ( `` '' lupoid '' '' ) hepatitis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
64,
77
]
} | {
"id": "C0019158",
"name": ") hepatit",
"pos": [
213,
222
]
} |
these theories are not necessarily mutually exclusive , and many of the phenotypic changes in senescent hepatocytes , fibroblasts and other cells are compatible with several different theories . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
118,
129
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
140,
145
]
} |
the times from the onset of chest pain to death were similar in the two groups ( 5.7 +/- 5.8 days for patients with rupture versus 4.2 +/- 4.9 days for control subjects ) , and there were no differences in the incidences of systemic hypertension , diabetes mellitus , hypercholesterolemia , history of myocardial infarction , or angina pectoris . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
28,
38
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
329,
344
]
} |
previously , in endometrial curettage and hysterectomy specimens , pstt was not distinguished from choriocarcinoma or sarcoma , although in most cases the natural history had been benign . | NA | {
"id": "C0206666",
"name": "pstt",
"pos": [
67,
71
]
} | {
"id": "C0008497",
"name": "choriocarcinoma",
"pos": [
99,
114
]
} |
we treated the stimulators with sublytic doses of a variety of agents ( ouabain , ultra-violet radiation , 5-fluorouracil and colchicine ) , which have been reported to inhibit their stimulating capacity , and then in parallel experiments , we examined the treated cells for their capacity to stimulate allogeneic cells and their ability to respond to con a . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
11,
14
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
303,
319
]
} |
the distribution of hnk 1+ cells within the tumors was diffuse except in nodular lymphomas of follicular center cell origin ( centroblastic/centrocytic = cb/cc nhl ) . | NA | {
"id": "C0024301",
"name": "lymphomas",
"pos": [
81,
90
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
160,
163
]
} |
the kinetics of vascular leakage and tachyphylaxis induced by histamine and bradykinin were examined in rabbit skin and were compared with the kinetics of tachyphylaxis of neutrophil accumulation in lesions induced with the chemotaxin formylmethionyl-leucyl-phenylalanine ( fmlp ) . | NA | {
"id": "C0008013",
"name": "chemotaxin",
"pos": [
224,
234
]
} | {
"id": "C0027229",
"name": "formylmethionyl-leucyl-phenylalanine",
"pos": [
235,
271
]
} |
marked cross-desensitization occurred between the two agents , and lesions initiated with the chemotaxin fmlp were desensitized to restimulation with a mixture of histamine and bradykinin . | NA | {
"id": "C0008013",
"name": "chemotaxin",
"pos": [
94,
104
]
} | {
"id": "C0027229",
"name": "fmlp",
"pos": [
105,
109
]
} |
the present experiments indicate that expression of receptors for vascular permeability agents and the chemotaxin fmlp are independent events with distinct kinetics . | NA | {
"id": "C0008013",
"name": "chemotaxin",
"pos": [
103,
113
]
} | {
"id": "C0027229",
"name": "fmlp",
"pos": [
114,
118
]
} |
mechanism of follicular trapping : double immunocytochemical evidence for a contribution of locally produced antibodies in follicular trapping of immune complexes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
109,
119
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
146,
152
]
} |
it was shown in earlier studies that extracellular antibodies trapped in the follicles represent antigen-antibody complexes having free binding sites for the antigen . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
97,
123
]
} |
the present report describes a study made on two t-lymphocyte/polyoma virus transformed fibroblast hybrid subclones ( 3d1c and 3d1n ) with markedly different adhesive properties : indeed , 3d1c cells were at the same time more readily agglutinated with concanavalin a and more easily disagglutinated than 3d1n . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
88,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
194,
199
]
} |
the cellular response of sheep to challenge with cultivated allogeneic tumor cells derived from naturally occurring ovine squamous cell carcinomata . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
4,
12
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
60,
70
]
} |
the conjugate was found to be of a higher molecular size than the original protein , apparently due to the cross-linking of albumin molecules by the dialdehydes generated during the periodate oxidation of adenosine . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
75,
82
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
124,
131
]
} |
as this alteration in sympathetic activity may be mediated in part by alpha-adrenergic receptors in the central nervous system , the current study examined alpha 1-adrenergic receptors in various brain areas of shr and normotensive wistar-kyoto control rats ( wky ) . | NA | {
"id": "C0034784",
"name": "alpha-adrenergic receptors",
"pos": [
70,
96
]
} | {
"id": "C0001638",
"name": "alpha 1-adrenergic receptors",
"pos": [
156,
184
]
} |
the alpha 1-adrenergic receptor number and apparent affinity constants of brain sections of both young prehypertensive animals ( 4 weeks old ) and mature hypertensive animals ( 12 weeks old ) were studied with the alpha 1-adrenergic receptor antagonist [ 3h ] wb-4101 to label the alpha-adrenergic receptor . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenergic receptor",
"pos": [
4,
31
]
} | {
"id": "C0034784",
"name": "alpha-adrenergic receptor",
"pos": [
281,
306
]
} |
we found that this sensitive method specifically measured angiotensin- ( 1-8 ) octapeptide and demonstrated that true angiotensin ii virtually disappears during converting-enzyme inhibition . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
58,
69
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
118,
132
]
} |
three groups of uninephrectomized rats were studied for 32 days on one of the following regimens : ( 1 ) high nacl diet plus doca , ( 2 ) high dietary sodium intake without chloride plus doca , and ( 3 ) high nacl diet without doca . | NA | {
"id": "C0011710",
"name": "doca",
"pos": [
125,
129
]
} | {
"id": "C0813203",
"name": "doca",
"pos": [
227,
231
]
} |
in the doca-nacl group , higher blood pressures were associated with a more positive chloride balance and total carcass chloride content ( p less than 0.01 ) , an expanded extracellular fluid volume ( p less than 0.05 ) , and increased renal vascular resistance ( p less than 0.01 ) . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
12,
16
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
120,
128
]
} |
the effective human urinary kallikrein inhibitors were further examined for their effect on other serine proteases , including human plasma kallikrein , plasmin , complement components ( c1s , c1r ) , bovine coagulation factors ( iia , ixa , and xa ) , elastase , and trypsin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
98,
114
]
} | {
"id": "C0016016",
"name": "plasmin",
"pos": [
153,
160
]
} |
the effective human urinary kallikrein inhibitors were further examined for their effect on other serine proteases , including human plasma kallikrein , plasmin , complement components ( c1s , c1r ) , bovine coagulation factors ( iia , ixa , and xa ) , elastase , and trypsin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
98,
114
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
253,
261
]
} |
the effective human urinary kallikrein inhibitors were further examined for their effect on other serine proteases , including human plasma kallikrein , plasmin , complement components ( c1s , c1r ) , bovine coagulation factors ( iia , ixa , and xa ) , elastase , and trypsin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
98,
114
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
268,
275
]
} |
the effective human urinary kallikrein inhibitors were further examined for their effect on other serine proteases , including human plasma kallikrein , plasmin , complement components ( c1s , c1r ) , bovine coagulation factors ( iia , ixa , and xa ) , elastase , and trypsin . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
28,
38
]
} | {
"id": "C0005789",
"name": "coagulation",
"pos": [
208,
219
]
} |
these peptides showed little inhibition of the circulating serine proteases but yielded a ki for the nonspecific protease trypsin in the microm range . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
59,
75
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
113,
121
]
} |
these peptides showed little inhibition of the circulating serine proteases but yielded a ki for the nonspecific protease trypsin in the microm range . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
59,
75
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
122,
129
]
} |
antibodies were made specific for adhesion antigens by adsorption with isogenic , nonadhesive mutants ( for rabbit polyclonal adsorbed antibody ) or selection based on nonreactivity with two nonadhesive mutants ( for monoclonal antibody ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
217,
236
]
} |
adsorbed antibody and monoclonal antibody were shown to be specific for fimbriae ( antigen 1 ) , since both antibodies could be seen by immune electron microscopy to bind 3.6-nm fimbriae , reacted only with the fimbriated parent and not the mutants in a whole bacterial cell enzyme-linked immunosorbent assay , and could immunoprecipitate fimbriae from fimbrial extracts of fw213 . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
22,
41
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
108,
118
]
} |
only adsorbed antibody and monoclonal antibody were capable of blocking the adhesion of fw213 to saliva-coated hydroxyapatite . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
14,
22
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
27,
46
]
} |
these observations indicate that the c. jejuni enterotoxin contains a b subunit that bears an immunological relationship with the b subunits of cholera toxin and lt . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
47,
58
]
} | {
"id": "C0040549",
"name": "lt",
"pos": [
162,
164
]
} |
the cells were grown at ph 7.0 to 3.2 in the absence of fluoride and from ph 7.0 to 5.4 with 20 mm naf . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
56,
64
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
99,
102
]
} |
fluoride stimulated glycolytic activity by cells incubated at ph 7.0 and by cells growing with 20 mm naf , provided that the ph of growth remained at or above 6.0 . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
0,
8
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
101,
104
]
} |
this strain was capable of growth on defined medium plus raffinose or sucrose and generated reducing sugars from a sucrose substrate . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
101,
107
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
115,
122
]
} |
we here report that the native toxin binds naturally occurring human serum immunoglobulin g antibodies to form immune complexes with potent complement-activating capacity . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
92,
102
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
111,
127
]
} |
the effect of the o-antigen in the lipopolysaccharide produced by the smooth phenocopy on the binding of antibody to the lambda receptor was determined . | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
18,
27
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
35,
53
]
} |
the results suggest that the increased resistance to the lethal action of normal human serum shown by the smooth phenocopy may be due to the blocking of antibody binding sites by the o-antigen of lipopolysaccharide , thereby preventing activation of the classical pathway of complement . | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
183,
192
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
196,
214
]
} |
antiserum prepared against hcl-treated bacteria was found to react with both antigens to the same extent ( i ) in the passive hemolysis test , ( ii ) in the passive hemolysis inhibition test , and ( iii ) in absorption experiments , suggesting that antibodies in this antiserum recognize an antigenic determinant equally present in lipa-ac and lipa-hcl . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
77,
85
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
291,
312
]
} |
antiserum prepared against hcl-treated bacteria was found to react with both antigens to the same extent ( i ) in the passive hemolysis test , ( ii ) in the passive hemolysis inhibition test , and ( iii ) in absorption experiments , suggesting that antibodies in this antiserum recognize an antigenic determinant equally present in lipa-ac and lipa-hcl . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
249,
259
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
268,
277
]
} |
however , the antiserum failed to react with the heterologous antigen ( lipa-hcl ) in the hemolysis test and during absorption , whereas in inhibition studies interaction of this antiserum with both antigens was observed . | NA | {
"id": "C0003333",
"name": "heterologous antigen",
"pos": [
49,
69
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
199,
207
]
} |
the lipopolysaccharide ( i.e. , endotoxin ) was shown to induce de novo synthesis of ir-acth and ir-endorphins . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
4,
22
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
32,
41
]
} |
the lymphocyte-derived ir-endorphin comigrated with alpha- and gamma-endorphin at approximately 1,800 daltons and was shown to bind to brain opiate receptors . | NA | {
"id": "C0014242",
"name": "endorphin",
"pos": [
26,
35
]
} | {
"id": "C0061041",
"name": "gamma-endorphin",
"pos": [
63,
78
]
} |
an epidemiological study was performed to assess whether environmental pollution by cadmium as found in cadmium-polluted areas of the federal republic of germany is associated with an increased prevalence of biological signs of kidney dysfunction in population groups non-occupationally exposed to heavy metals . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
84,
91
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
298,
310
]
} |
the study was run in two industrial areas known to be highly contaminated by cadmium , lead and other heavy metals , viz . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
77,
84
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
102,
114
]
} |
the study was run in two industrial areas known to be highly contaminated by cadmium , lead and other heavy metals , viz . | NA | {
"id": "C0023175",
"name": "lead",
"pos": [
87,
91
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
102,
114
]
} |
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