text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
however , with respect to the urinary excretion of low molecular weight proteins ( beta 2-microglobulin , retinol-binding protein ) , albuminuria , total proteinuria , aminoaciduria , phosphaturia and some other biological findings , no significant differences between the study populations were noted . | NA | {
"id": "C0001925",
"name": "albuminuria",
"pos": [
134,
145
]
} | {
"id": "C0033687",
"name": "proteinuria",
"pos": [
154,
165
]
} |
in studies of the ph response of dental plaque in situ to rinses with conventional sugars , glucose and maltose give similar falls in ph , and fructose only slightly smaller effects compared with sucrose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
83,
89
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
196,
203
]
} |
of the sugar alcohols , sorbitol , mannitol , maltitol and lactitol are all slowly fermented to acid by oral bacterial , and xylitol is virtually non-fermentable . | NA | {
"id": "C0038654",
"name": "sugar alcohols",
"pos": [
7,
21
]
} | {
"id": "C0037688",
"name": "sorbitol",
"pos": [
24,
32
]
} |
of the sugar alcohols , sorbitol , mannitol , maltitol and lactitol are all slowly fermented to acid by oral bacterial , and xylitol is virtually non-fermentable . | NA | {
"id": "C0038654",
"name": "sugar alcohols",
"pos": [
7,
21
]
} | {
"id": "C0024730",
"name": "mannitol",
"pos": [
35,
43
]
} |
of the sugar alcohols , sorbitol , mannitol , maltitol and lactitol are all slowly fermented to acid by oral bacterial , and xylitol is virtually non-fermentable . | NA | {
"id": "C0038654",
"name": "sugar alcohols",
"pos": [
7,
21
]
} | {
"id": "C0043369",
"name": "xylitol",
"pos": [
125,
132
]
} |
lycasin , a synthetic sweetener containing sorbitol , maltitol and some higher sugar alcohols gives effects similar to its major constituents . | NA | {
"id": "C0037688",
"name": "sorbitol",
"pos": [
43,
51
]
} | {
"id": "C0038654",
"name": "sugar alcohols",
"pos": [
79,
93
]
} |
peripheral serum levels of testosterone , immunoreactive oestrogens ( e2 ) , fsh , lh , prolactin and growth hormone ( hgh ) and two steroid-sensitive proteins , 'pregnancy-associated alpha 2-glycoprotein ' ( alpha 2-pag ) and sex hormone binding globulin ( shbg ) , were measured in patients with prostatic cancer before treatment and after orchidectomy or during combined oral and intramuscular oestrogen treatment . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
102,
116
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
119,
122
]
} |
a more detailed comparison of 2 ifn-alpha subtypes showed that a daily dose of 1 microgram ifn-alpha a was more effective than the same dose of ifn-alpha d , but as this ifn had approximately 30 times less antiviral activity on human cells than ifn-alpha d , these ifns were probably at least equally effective in terms of human cell units . | NA | {
"id": "C0021734",
"name": "2 ifn-alpha",
"pos": [
30,
41
]
} | {
"id": "C0021747",
"name": "ifns",
"pos": [
265,
269
]
} |
in 16 healthy volunteers and in 39 patients with liver diseases ( fatty liver , chronic persistent and chronic active hepatitis , hepatic cirrhosis ) a simplified aminopyrine breath test ( abt ) was carried out using a `` '' tracer '' '' dose of 3 mg ( 111 kbq ) 14c-aminopyrine . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
49,
63
]
} | {
"id": "C0015695",
"name": "fatty liver",
"pos": [
66,
77
]
} |
in 16 healthy volunteers and in 39 patients with liver diseases ( fatty liver , chronic persistent and chronic active hepatitis , hepatic cirrhosis ) a simplified aminopyrine breath test ( abt ) was carried out using a `` '' tracer '' '' dose of 3 mg ( 111 kbq ) 14c-aminopyrine . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
49,
63
]
} | {
"id": "C0023890",
"name": "hepatic cirrhosis",
"pos": [
130,
147
]
} |
activated charcoal in high doses effectively prevents the absorption of that fraction of dextropropoxyphene which is in the stomach at the time of charcoal administration . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
0,
18
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
147,
155
]
} |
these studies employed a variety of analytical methods and revealed that young children in areas with large ranches , livestock-raising , and a high proportion of agricultural wage-earners presented a higher mortality and had a poorer nutritional status than children in areas with small properties , crop agriculture , and self-employed family workers . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
73,
78
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
259,
267
]
} |
no significant difference between the various nitroimidazoles could be found in the dark reaction , but in the u.v.-irradiated system the order of reactivity ( misonidazole greater than benznidazole greater than metronidazole approximately equal to ornidazole ) was the same as the reported relative mutagenic , cytotoxic and radiosensitizing potency of the compounds . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
46,
61
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
160,
172
]
} |
no significant difference between the various nitroimidazoles could be found in the dark reaction , but in the u.v.-irradiated system the order of reactivity ( misonidazole greater than benznidazole greater than metronidazole approximately equal to ornidazole ) was the same as the reported relative mutagenic , cytotoxic and radiosensitizing potency of the compounds . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
46,
61
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
212,
225
]
} |
no significant difference between the various nitroimidazoles could be found in the dark reaction , but in the u.v.-irradiated system the order of reactivity ( misonidazole greater than benznidazole greater than metronidazole approximately equal to ornidazole ) was the same as the reported relative mutagenic , cytotoxic and radiosensitizing potency of the compounds . | NA | {
"id": "C0028179",
"name": "nitroimidazoles",
"pos": [
46,
61
]
} | {
"id": "C0029274",
"name": "ornidazole",
"pos": [
249,
259
]
} |
among those sulphur compounds , an important amount of plasma thiols can be related to a protection of cysteamine in the digestive tract . | NA | {
"id": "C0038776",
"name": "sulphur compounds",
"pos": [
12,
29
]
} | {
"id": "C0038734",
"name": "thiols",
"pos": [
62,
68
]
} |
the intracellular : extracellular concentration ratio for the 2-nitroimidazole , misonidazole was constant at about 0.7 for phe = 6.6-7.6 , whereas the weak base , ro 03-8799 ( 1- ( 2-nitro-1-imidazolyl ) -3-n-piperidino-2-propanol ) was concentrated intracellularly at phe = 7.3-7.4 by a factor of 3.3 , the factor increasing from about 0.8 at phe = 6.0 , to 7.5 at phe = 7.85 . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
64,
78
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
81,
93
]
} |
the effect of extracellular ph ( phe ) on the radiosensitization of hypoxic chinese hamster v79 cells in vitro by the 2-nitroimidazole , misonidazole , and analogues substituted with basic or acid functions has been studied . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
120,
134
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
137,
149
]
} |
abnormal retention of x-irradiated ataxia-telangiectasia fibroblasts in g2 phase of the cell cycle : cellular rna content , chromatin stability and the effects of 3-aminobenzamide . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
101,
109
]
} |
characteristics of the nerve growth factor receptors and a nerve growth factor receptor -- nerve growth factor covalent complex . | NA | {
"id": "C0132173",
"name": "nerve growth factor receptors",
"pos": [
23,
52
]
} | {
"id": "C0254837",
"name": "nerve growth factor",
"pos": [
91,
110
]
} |
the metabolism of all-trans- [ 15-14c ] retinoic acid in vitamin a-adequate or vitamin a-deficient rats fed retinoic acid was studied following intratesticular injection . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
57,
66
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
108,
121
]
} |
discriminant analysis of eleven currently utilized blood markers of the phlogistic reaction and of the nutritional status has afforded the selection of the two most reliable acute-phase reactants ( orosomucoid and c-reactive protein ) and visceral proteins ( albumin and prealbumin ) . | NA | {
"id": "C0001347",
"name": "acute-phase reactants",
"pos": [
174,
195
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
198,
209
]
} |
discriminant analysis of eleven currently utilized blood markers of the phlogistic reaction and of the nutritional status has afforded the selection of the two most reliable acute-phase reactants ( orosomucoid and c-reactive protein ) and visceral proteins ( albumin and prealbumin ) . | NA | {
"id": "C0001347",
"name": "acute-phase reactants",
"pos": [
174,
195
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
214,
232
]
} |
discriminant analysis of eleven currently utilized blood markers of the phlogistic reaction and of the nutritional status has afforded the selection of the two most reliable acute-phase reactants ( orosomucoid and c-reactive protein ) and visceral proteins ( albumin and prealbumin ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
248,
256
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
274,
281
]
} |
influence of chlorhexidine in ethanol and in isopropanol on the bacterial colonization of the umbilicus of newborns . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
30,
37
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
45,
56
]
} |
in spite of isopropanol being reported as a more efficient skin disinfectant than ethanol in several experimental models , no significant differences were seen in the frequency of navel colonization or in infection rates between the two treatment groups . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
12,
23
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
82,
89
]
} |
( immune serum against reticulo-endothelial system ) and placebo was designed for treatment of different bladder diseases ( interstitial cystitis sui generis , after radiotherapy and in connection with multiple transurethral resections of bladder tumour , cystitis granularis ) . | NA | {
"id": "C0005686",
"name": "of",
"pos": [
92,
94
]
} | {
"id": "C0010692",
"name": "cystitis",
"pos": [
256,
264
]
} |
( immune serum against reticulo-endothelial system ) and placebo was designed for treatment of different bladder diseases ( interstitial cystitis sui generis , after radiotherapy and in connection with multiple transurethral resections of bladder tumour , cystitis granularis ) . | NA | {
"id": "C0282488",
"name": "interstitial cystitis",
"pos": [
124,
145
]
} | {
"id": "C0010692",
"name": "cystitis",
"pos": [
256,
264
]
} |
twenty-four patients ( 17 women and 5 men , aged 41-75 , with interstitial cystitis , and 2 women , aged 42 and 75 , with cystitis granularis ) were included in this study . | NA | {
"id": "C0282488",
"name": "interstitial cystitis",
"pos": [
62,
83
]
} | {
"id": "C0010692",
"name": "cystitis",
"pos": [
122,
130
]
} |
the ocular toxicity of liposome-intercalated amphotericin b and commercial amphotericin b were compared after intravitreal injection in healthy pigmented rabbits . | NA | {
"id": "C1145701",
"name": "liposome",
"pos": [
23,
31
]
} | {
"id": "C0002679",
"name": "amphotericin b",
"pos": [
75,
89
]
} |
neopterin , sepiapterin , and biopterin synthesis by lens , retina , and ciliary body-iris of rat and human indicates pteridine formation from their precursor , gtp . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
0,
9
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
30,
39
]
} |
the pteridine biosynthesis was higher in the retina ( neopterin 422 +/- 27 , 260 +/- 24 ; sepiapterin 135 +/- 12 , 118 +/- 14 ; biopterin 76 +/- 10 , 68 +/- 8 nanomoles/g soluble protein/hr , in rat and human , respectively ) than in the ciliary body-iris and lens . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
54,
63
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
128,
137
]
} |
estramustine , a nitrogen mustard derivative of estradiol-17 beta widely used for treatment of prostatic cancer , was found to inhibit the proliferative response of mouse lymphocytes to t ( concanavalin a ) and b ( lipopolysaccharide ) cell mitogens in vitro . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
0,
12
]
} | {
"id": "C0014912",
"name": "estradiol-17 beta",
"pos": [
48,
65
]
} |
heparin is a highly sulfated , polydisperse and heterogeneous glycosaminoglycan which has been well characterized for its ability to regulate multiple sites in the complement cascade . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
0,
7
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
62,
79
]
} |
the diffusion element serves to make sampler performance relatively independent of the properties of the type of carbon used . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
14,
21
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
113,
119
]
} |
the abnormal hemoglobin focused at a slightly more anodic position than hb a in thin layer polyacrylamide gel electrofocusing . | NA | {
"id": "C0019047",
"name": "abnormal hemoglobin",
"pos": [
4,
23
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
72,
74
]
} |
hemoglobin mobile had an oxygen affinity lower than that of hemoglobin a , as observed by others . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
0,
10
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
60,
72
]
} |
however , in mixtures with hemoglobin s , hemoglobin mobile appeared to impair gelation or increase solubility to a slightly greater extent than did hemoglobin a . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
27,
37
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
149,
161
]
} |
tbpa fluctuations were analysed together with those of other nutritional and inflammatory markers including albumin ( alb ) , some acute-phase reactant proteins , c-reactive protein ( crp ) , orosomucoid also named alpha 1-acid-glycoprotein ( alpha 1gp ) , alpha 1-antitrypsin ( alpha 1at ) as well as cortisol and haematocrit . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
131,
142
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
163,
181
]
} |
tbpa fluctuations were analysed together with those of other nutritional and inflammatory markers including albumin ( alb ) , some acute-phase reactant proteins , c-reactive protein ( crp ) , orosomucoid also named alpha 1-acid-glycoprotein ( alpha 1gp ) , alpha 1-antitrypsin ( alpha 1at ) as well as cortisol and haematocrit . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
131,
142
]
} | {
"id": "C0029297",
"name": "alpha 1-acid-glycoprotein",
"pos": [
215,
240
]
} |
tbpa fluctuations were analysed together with those of other nutritional and inflammatory markers including albumin ( alb ) , some acute-phase reactant proteins , c-reactive protein ( crp ) , orosomucoid also named alpha 1-acid-glycoprotein ( alpha 1gp ) , alpha 1-antitrypsin ( alpha 1at ) as well as cortisol and haematocrit . | NA | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
131,
142
]
} | {
"id": "C0002191",
"name": "alpha",
"pos": [
279,
284
]
} |
birth weight , feeding practices and weight-for-age of punjabi children in the uk and in the rural punjab . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
0,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
37,
43
]
} |
in neonatal rat pups up to day 6 nearly 90 % of all calcitonin cells are also somatostatin immunoreactive and 45 % of these cells also show immunoreactivity to a c-terminal gastrin/cholecystokinin antiserum ( cck-4-like immunoreactivity ) . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
173,
180
]
} | {
"id": "C0039659",
"name": "cck-4",
"pos": [
209,
214
]
} |
dna-feulgen values associated with various ovarian nuclei from egg chambers at different stages of development were used to assess a base line dna content for ovarian tissues and to estimate the extent of dna replication in the nurse cells and follicle cells of growing and mature egg chambers . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
287,
288
]
} |
this syndrome may not be recognized as heartworm-associated and may be confused with other disorders , some being associated with a poor prognosis and requiring different therapy . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
5,
13
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
91,
100
]
} |
the authors previously have shown that both supraphysiologic dosages of human chorionic gonadotropin ( hcg ) and physiologic dosages of human luteinizing hormone ( hlh ) can reinitiate sperm production in short-term ( four months ) gonadotropin-suppressed normal men who have prepubertal fsh levels . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
72,
100
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
232,
244
]
} |
the effect on sperm production of the selective fsh deficiency produced by hcg plus t administration after the period of prolonged gonadotropin suppression was determined . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
75,
78
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
131,
143
]
} |
single , intermittent , and successive injections of the antibiotic were almost equally effective against ehrlich carcinoma , imc carcinoma and sarcoma 180 tumor , but successive injections showed more efficacy than the other schedules against meth a fibrosarcoma and lewis lung carcinoma . | NA | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
114,
123
]
} | {
"id": "C0243038",
"name": "lewis lung carcinoma",
"pos": [
268,
288
]
} |
frequency of emergence of cl . difficile in the 6 volunteers in each of the cephalosporin groups were as follows : cephaloridine 0 , cephazolin , 1 cefuroxime 1 , cefoxitin 2 , cefotaxime 2 , latamoxef 3 , ceftriaxone 2 , cefotetan 4 . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
76,
89
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
115,
128
]
} |
frequency of emergence of cl . difficile in the 6 volunteers in each of the cephalosporin groups were as follows : cephaloridine 0 , cephazolin , 1 cefuroxime 1 , cefoxitin 2 , cefotaxime 2 , latamoxef 3 , ceftriaxone 2 , cefotetan 4 . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
148,
158
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
177,
187
]
} |
frequency of emergence of cl . difficile in the 6 volunteers in each of the cephalosporin groups were as follows : cephaloridine 0 , cephazolin , 1 cefuroxime 1 , cefoxitin 2 , cefotaxime 2 , latamoxef 3 , ceftriaxone 2 , cefotetan 4 . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
177,
187
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
206,
217
]
} |
we conclude that measurement of plasma endorphin levels suggests relationships between endogenous opioid peptides and ventilatory responses to co2 that are not apparent in studies limited to assessing the effect of naloxone . | NA | {
"id": "C0014242",
"name": "endorphin",
"pos": [
39,
48
]
} | {
"id": "C0205753",
"name": "endogenous opioid",
"pos": [
87,
104
]
} |
maximal o2 consumption ( vo2max ) declined only 16 % with a decrease in hemoglobin ( hb ) from 14 to 8 g/dl and fell sharply only below a hb of 7 g/dl . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
72,
82
]
} | {
"id": "C0019016",
"name": "a hb",
"pos": [
136,
140
]
} |
the gastrocnemius was less severely affected by suspension than by immobilization techniques , whereas the soleus atrophied ( by weight ) similarly , suggesting that muscle atrophy in the suspension model is distinctly different from immobilization atrophy . | NA | {
"id": "C0026846",
"name": "muscle atrophy",
"pos": [
166,
180
]
} | {
"id": "C0333641",
"name": "atrophy",
"pos": [
249,
256
]
} |
southern blot analysis indicated that the dna isolated from infected petunia cells was not detectably contaminated by bacterial dna from lysed agrobacterium cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
42,
45
]
} | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
118,
131
]
} |
of some 3,000 transformants tested , 6 were sdh positive and had phv32 integrated close to the sdh operon . | NA | {
"id": "C0038615",
"name": "sdh",
"pos": [
44,
47
]
} | {
"id": "C0283592",
"name": "sdh",
"pos": [
95,
98
]
} |
the tmpa and tmpb proteins are the products of in vivo proteolytic cleavage from precursor proteins which are 2 and 4 kilodaltons larger , respectively , than the mature proteins . | NA | {
"id": "C0033665",
"name": "precursor proteins",
"pos": [
81,
99
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
170,
178
]
} |
unlike receptors for other klebsiella phages , the bacteriophage fc3-1 receptor was shown to be lipopolysaccharide , specifically the polysaccharide fraction ( o-antigen and core region ) . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
96,
114
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
160,
169
]
} |
mutants resistant to this phage were isolated and were found to be devoid of lipopolysaccharide o-antigen by several criteria but to contain capsular material serologically identical to that of the wild type . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
77,
95
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
96,
105
]
} |
we suggest that deoxyribonucleoside triphosphate pool imbalances , the removal of uracil incorporated into dna during thymine starvation , and the induction of reca-dependent dna repair functions all may play a role in thymineless mutagenesis . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
82,
88
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
219,
226
]
} |
polyadenylate [ poly ( a ) ] tracts were isolated by digestion with rnase a and rnase t1 after 3 ' end labeling of the poly ( a ) + rna with rna ligase . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
68,
73
]
} | {
"id": "C0950373",
"name": "rnase",
"pos": [
80,
85
]
} |
the lengths of these poly ( a ) sequences are in agreement with estimates obtained from rnase a and rnase t1 digestions of [ 3h ] adenine-labeled poly ( a ) + rna molecules . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
88,
93
]
} | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
100,
108
]
} |
self-reported levels of pain , anxiety , and depression , and plasma levels of beta-endorphin , epinephrine , norepinephrine , dopamine , and serotonin were measured in 19 arthritic pain patients before and after hypnosis designed to produce pain reduction . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
96,
107
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
110,
124
]
} |
hydrogenase [ hydrogen : ferricytochrome c3 oxidoreductase , ec 1.12.2.1 ] solubilized and purified from the particulate fraction of desulfovibrio vulgaris miyazaki f ( iam 12604 ) contains 8 iron and 8 labile sulfide ions in one molecule which is composed of two unequal subunits ( mr : 60,000 + 29,000 ) . | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
0,
11
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
44,
58
]
} |
from the results obtained by the measurement of proton extrusion in nitrite reductase-deficient mutants , nadh-nitrite reductase system is suggested to involve the proton extrusion in whole cells of e. coli . | NA | {
"id": "C0028135",
"name": "nitrite reductase",
"pos": [
68,
85
]
} | {
"id": "C0068815",
"name": "nadh-nitrite reductase",
"pos": [
106,
128
]
} |
antibody from one clone was coupled to cnbr-activated sepharose 4b and the monoclonal antibody-sepharose was shown to be very useful for isolating rat tyrosine 3-monooxygenase from crude preparations . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
75,
94
]
} |
the antigenic determinant of ecma 2 antigen was found to involve an alpha-galactosyl residue , since alpha-galactosidase from coffee bean , but not other glycosidases , abolished the antigenic activity . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
4,
25
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
183,
192
]
} |
( v ) facilitation of the transfer of both neutral lipids ( cholesteryl esters and triglycerides ) and phosphatidylcholine between high density lipoproteins and d less than 1.063 g/ml lipoproteins ; | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
51,
57
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
184,
196
]
} |
addition of phorbol myristate acetate to macrophages in the presence of calcium ionophore ( a23187 ) at a concentration which alone did not stimulate arachidonate metabolism resulted in a synergistic increase ( 50-fold ) in leukotriene c4 synthesis compared to phorbol ester or a23187 alone . | NA | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
12,
37
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
261,
274
]
} |
under stripped conditions with minimum chloride the order of o2 affinity is : hb a ( glu ) much less than hb rush ( gln ) less than or equal to hb british columbia ( lys ) less than or equal to hb potomac ( asp ) less than or equal to hb alberta ( gly ) . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
85,
88
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
116,
119
]
} |
these subunits represent portions of all three fractions of the enzyme , i.e . flavoprotein , iron-protein , and insoluble or hydrophobic fractions . | NA | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
79,
91
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
99,
106
]
} |
some of these sera also reacted with intact hyaluronic acid and chondroitin but never with intact chondroitin sulfate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
64,
75
]
} | {
"id": "C0008466",
"name": "chondroitin sulfate",
"pos": [
98,
117
]
} |
the types of unsaturated fatty acids found in platelet phospholipids must be regulated by a series of controls which include specificity for activation and acylation as well as modification of circulating fatty acids by platelets prior to incubation into phospholipids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
13,
36
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
205,
216
]
} |
platelets incubated alone with 1-14c-labeled 5,8,11-20:3 , 5,8,11,14-20:4 , 5,8,11,14,17-20:5 , 7,10,13,16,19-22:5 , or 4,7,10,13,16,19-22:6 incorporated each of these acids into individual phosphoglycerides with phosphatidylinositol having the highest specific activity followed by phosphatidylcholine with phosphatidylserine approximately equal to phosphatidylethanolamine . | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
190,
207
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
213,
233
]
} |
platelets incubated alone with 1-14c-labeled 5,8,11-20:3 , 5,8,11,14-20:4 , 5,8,11,14,17-20:5 , 7,10,13,16,19-22:5 , or 4,7,10,13,16,19-22:6 incorporated each of these acids into individual phosphoglycerides with phosphatidylinositol having the highest specific activity followed by phosphatidylcholine with phosphatidylserine approximately equal to phosphatidylethanolamine . | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
190,
207
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
283,
302
]
} |
platelets incubated alone with 1-14c-labeled 5,8,11-20:3 , 5,8,11,14-20:4 , 5,8,11,14,17-20:5 , 7,10,13,16,19-22:5 , or 4,7,10,13,16,19-22:6 incorporated each of these acids into individual phosphoglycerides with phosphatidylinositol having the highest specific activity followed by phosphatidylcholine with phosphatidylserine approximately equal to phosphatidylethanolamine . | NA | {
"id": "C0162448",
"name": "phosphoglycerides",
"pos": [
190,
207
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
350,
374
]
} |
these observations suggest that the fifth ligand to the heme iron of diarylpropane oxygenase is a neutral histidine and that the iron environment must resemble that of the oxygen transport protein , myoglobin , rather than that of the peroxidases , catalase , or p-450 . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
235,
246
]
} | {
"id": "C0007367",
"name": "catalase",
"pos": [
249,
257
]
} |
we describe herein the effects of marek 's disease herpesvirus ( mdv ) on cholesterol and cholesteryl ester metabolism in cultured chicken arterial smooth muscle cells . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
74,
85
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
90,
107
]
} |
1 ) the inhibitory effects of gtp and guanyl-5'-yl imidodiphosphate , which were clearly seen in +/+ membranes , were absent in the ob/ob membranes . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
30,
33
]
} | {
"id": "C0018366",
"name": "guanyl-5",
"pos": [
38,
46
]
} |
apo-e is commonly polymorphic in the population and the data suggest that the genomic clone was derived from the epsilon 4 apo-e allele , whereas the cdna clones were derived from the epsilon 3 apo-e allele . | NA | {
"id": "C0003595",
"name": "apo-e",
"pos": [
0,
5
]
} | {
"id": "C0052199",
"name": "epsilon 3 apo-e",
"pos": [
184,
199
]
} |
analysis of the effects of these mutations on rrna structure , and of the impact of these drugs on translation , should help to elucidate the role of the small subunit ribosomal rna in ribosome function . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
46,
50
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
178,
181
]
} |
the highly increased fibrinolytic activity of hela cells , treated with the tumor promoting phorbol ester , phorbol myristate acetate ( pma ) , correlates with equally increased levels of tissue-type plasminogen activator ( t-pa ) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-pa-specific mrna . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
92,
105
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
108,
133
]
} |
analysis of the radioactive peaks by amino acid analysis confirmed that it is the serine residue that reacts with the beta-lactam ring of penicillin . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
118,
129
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
138,
148
]
} |
the binding at a common site of three types of beta-lactam ( a penicillin , a cephalosporin , a monocyclic beta-lactam ) and a desazacyclobutanone has been observed in fourier difference maps . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
63,
73
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
107,
118
]
} |
when vldl and hdl were re-isolated after a lipolysis experiment , both lipoproteins stimulated cetp activity . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
5,
9
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
71,
83
]
} |
lipids accumulating in vldl remnants and hdl as a result of lipolysis may augment binding of cetp to these lipoproteins , leading to more efficient transfer of cholesteryl esters from hdl to vldl . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
0,
6
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
107,
119
]
} |
lipids accumulating in vldl remnants and hdl as a result of lipolysis may augment binding of cetp to these lipoproteins , leading to more efficient transfer of cholesteryl esters from hdl to vldl . | NA | {
"id": "C0065063",
"name": "vldl remnants",
"pos": [
23,
36
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
107,
119
]
} |
in this report , we demonstrate that the affinity of factor ixa , but not factor ix , for the cell surface is increased in the presence of both factors viii and x . | NA | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
53,
63
]
} | {
"id": "C0015491",
"name": "factor ix",
"pos": [
74,
83
]
} |
active site-blocked factor ixa , 5-dimethylaminonaphthalene-1-sulfonyl-glu-gly-arg-factor ixa , was a more effective inhibitor of factor x activation ( ki = 124 pm ) than was factor ix ( ki = 3.0 nm ) . | NA | {
"id": "C0015494",
"name": "factor ixa",
"pos": [
20,
30
]
} | {
"id": "C0015491",
"name": "factor ix",
"pos": [
175,
184
]
} |
in contrast , when factor ixa binding was studied in the absence of other coagulation factors , or in the presence of factor viii ( thrombin-activated or unactivated ) alone , this new high affinity site was not observed . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
74,
93
]
} | {
"id": "C0015506",
"name": "factor viii",
"pos": [
118,
129
]
} |
in contrast , when factor ixa binding was studied in the absence of other coagulation factors , or in the presence of factor viii ( thrombin-activated or unactivated ) alone , this new high affinity site was not observed . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
74,
93
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
132,
140
]
} |
consistent with the increased affinity of factor ixa binding in the presence of factors viii and x , cell-associated factor ixa coagulant activity decayed 7 times more slowly in the presence of these coagulation factors . | NA | {
"id": "C0015506",
"name": "factors viii",
"pos": [
80,
92
]
} | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
200,
219
]
} |
gel electrophoresis of the fragmented peptides indicated the presence of 20- , 18- , 16- , 14- , 12- , and 10-kda peptides in addition to two peptides smaller than 10 kda . | NA | {
"id": "C0030935",
"name": "fragmented peptides",
"pos": [
27,
46
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
142,
150
]
} |
the affinity of the chemoattractant receptor for n-formyl-methionyl-leucyl-phenylalanine ( fmet-leu-phe ) on human polymorphonuclear leukocytes ( pmns ) is regulated by guanine nucleotides , and chemoattractants stimulate increased intracellular camp levels in pmns . | NA | {
"id": "C0027229",
"name": "formyl-methionyl-leucyl-phenylalanine",
"pos": [
51,
88
]
} | {
"id": "C0008013",
"name": "chemoattractants",
"pos": [
195,
211
]
} |
these results suggest that disc membranes contain a cationic conductance which is permeable to ca2+ ions and which is regulated through the cooperative binding of at least 2 molecules of cyclic gmp to regulatory sites of the transport protein . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
52,
60
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
100,
104
]
} |
thus , although heme production could be reduced by desferrioxamine , succinylacetone , and hemin , cell iron uptake was enhanced only by the intracellular iron chelator . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
16,
20
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
92,
97
]
} |
one type of mutants resistant to these compounds ( designated as group a ) are highly resistant ( between 50 and 2000-fold ) to various cardiac glycosides and their genins such as ouabain , oleandrin , digitoxin , digitoxigenin , strophanthidin , convallatoxin , gitoxin , gitoxigenin , gitaloxin , bufalin , and digoxigenin , but exhibit no cross-resistance to sc4453 , a digoxin analog which contains a pyridazine ring in place of the lactone ring in the c-17 position . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
202,
211
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
214,
227
]
} |
one type of mutants resistant to these compounds ( designated as group a ) are highly resistant ( between 50 and 2000-fold ) to various cardiac glycosides and their genins such as ouabain , oleandrin , digitoxin , digitoxigenin , strophanthidin , convallatoxin , gitoxin , gitoxigenin , gitaloxin , bufalin , and digoxigenin , but exhibit no cross-resistance to sc4453 , a digoxin analog which contains a pyridazine ring in place of the lactone ring in the c-17 position . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
313,
324
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
373,
380
]
} |
however , the absence of detectable glucosyl exchange between dextrans and the lack of steady state dextran substrate inhibition indicate that glucosyl transfer to dextran must occur almost exclusively through the sequential route . | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
62,
70
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
164,
171
]
} |
based on the above observations , we have suggested a two-step activation of eif-2 molecules by the co-eif-2 protein complex for functional ternary complex formation . | NA | {
"id": "C1136317",
"name": "eif-2",
"pos": [
77,
82
]
} | {
"id": "C0013729",
"name": "eif-2",
"pos": [
103,
108
]
} |
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