text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
whether such a close association represents specific spatial arrangement required for genuine substrate channeling among the enzymes will be verified by future kinetic studies of the cross-linked enzyme complex . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
125,
132
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
196,
210
]
} |
the dependence of ter action on a circular substrate is not due to inhibition of the system by linear dna , nor does it appear to reflect a requirement for substrate superhelicity since circular p4 dna containing single strand scissions is subject to terminase action . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
102,
105
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
186,
194
]
} |
the protease appears to be a member of the thiol group of proteases based on its inhibition by leupeptin , antipain , chymostatin , ep-475 , and several other thiol protease inhibitors . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
4,
12
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
58,
67
]
} |
protease nexin contains approximately 6 % carbohydrate , with 2.3 % amino sugar , 1.1 % neutral sugar , and 3.0 % sialic acid . | NA | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
68,
79
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
96,
101
]
} |
although rnase t is highly specific for intact trna-c-c-a as a substrate and can hydrolyze all species in a mixed population of trna , it is inhibited by other rnas , such as poly ( a ) , rrna , 5 s rna , and trna-c-c . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
188,
192
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
210,
213
]
} |
together with the previously published sequence of the mouse 59-kda type i keratin ( steinert , p. m. , rice , r. h. , roop , d. r. , trus , b. l. , and steven , a. c. ( 1983 ) nature 302 , 794-800 ) these data allow us to make comparisons between two keratins which are coexpressed in an epithelial cell type and which coassemble into the same if . | NA | {
"id": "C1179970",
"name": "type i keratin",
"pos": [
68,
82
]
} | {
"id": "C0010803",
"name": "keratins",
"pos": [
252,
260
]
} |
to determine if this is true also for the pulsed enzyme , we examined the time course of dithionite reduction of the peroxide complex of the pulsed enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
49,
55
]
} | {
"id": "C0026741",
"name": "complex",
"pos": [
126,
133
]
} |
it has been previously shown that pulsed cytochrome c oxidase can interact with h2o2 and form a stable room temperature peroxide adduct ( bickar , d. , bonaventura , j. , and bonaventura , c. ( 1982 ) biochemistry 21 , 2661-2666 ) . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
80,
84
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
120,
128
]
} |
other proteins exhibiting partial homology with sigma 43 include the e. coli nusa protein , the e. coli htpr ( heat-shock regulatory gene ) product sigma 32 , and specific dna-binding proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0012940",
"name": "dna-binding",
"pos": [
172,
183
]
} |
the enzyme specifically cleaved the lys-arg pairs of pro-opiomelanocortin to yield mr = to 21,000-23,000 acth , beta-lipotropin , mr 13,000 and 4,500 acth , beta-endorphin , and a mr = 16,000 nh2-terminal glycopeptide , the products synthesized by the pituitary intermediate lobe in situ . | NA | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
53,
73
]
} | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
112,
127
]
} |
competition radioimmunoassays using a monoclonal antibody demonstrated that ssb-113 mutant protein , containing a single amino acid substitution at position 176 ( the penultimate residue ) , did not compete with ssb while ssb-1 protein ( with a single change at position 55 ) did compete with ssb . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
84,
98
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
228,
235
]
} |
the interactions of monovalent cations and of the k+-specific ionophore , valinomycin , with the ca2+-atpase of skeletal muscle of sarcoplasmic reticulum have been studied in the absence of cation gradients by their effects on enzyme turnover and on the atp plus ca2+-dependent enhanced fluorescence of the atp analogue , 2',3'-o- ( 2,4,6-trinitrocyclohexyldienylidine ) -adenosine 5'-triphosphate ( tnp-atp ) ( watanabe , t. , and inesi , g. ( 1982 ) j. biol . chem . 257 , 11510-11516 ) . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
20,
38
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
190,
196
]
} |
dissociation was blocked by proton ionophores and zn2+ , but was unaffected by inhibitors of the f1 , fo-atpase or the na+ , k+-atpase . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
105,
111
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
119,
121
]
} |
comparison of the homologous mhc sequences shows two positions at which mhc from dystrophic chicks differs from that of the white leghorn chicks * ( glu -- -- gln and met -- -- ile ) . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
149,
152
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
159,
162
]
} |
serum-free medium conditioned by colon carcinoma cells ( tcm ) was capable of stimulating several-fold the synthesis and secretion of proteoglycans in normal colon fibroblasts without inducing a mitogenic response . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
characterization of the proteoglycans synthesized in the absence of tcm revealed that colon fibroblasts synthesized at least three species of proteoglycans including a heparan sulfate proteoglycan which was associated primarily with the cell layer and two populations of proteoglycans which were predominantly released into the medium and contained chondroitin-dermatan sulfate side chains . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
237,
241
]
} |
several camp-dependent protein kinases were also detected in parietal cell homogenates , including a ca2+-phospholipid-sensitive or c kinase and two casein kinases which were tentatively identified as casein kinase i and ii . | NA | {
"id": "C0054846",
"name": "casein kinases",
"pos": [
149,
163
]
} | {
"id": "C0108554",
"name": "casein kinase",
"pos": [
201,
214
]
} |
addition of eif-4f also makes the mrna sensitive to nuclease indicating a similar unwinding role to that of eif-4a . | NA | {
"id": "C0058989",
"name": "eif-4f",
"pos": [
12,
18
]
} | {
"id": "C0058984",
"name": "eif-4a",
"pos": [
108,
114
]
} |
stoichiometric comparisons indicate that eif-4f is more than 20-fold more efficient than eif-4a in catalyzing this reaction . | NA | {
"id": "C0058989",
"name": "eif-4f",
"pos": [
41,
47
]
} | {
"id": "C0058984",
"name": "eif-4a",
"pos": [
89,
95
]
} |
the unwinding activity of eif-4f is inhibited by m7gdp , while that of eif-4a is not . | NA | {
"id": "C0058989",
"name": "eif-4f",
"pos": [
26,
32
]
} | {
"id": "C0058984",
"name": "eif-4a",
"pos": [
71,
77
]
} |
our results also suggest that the unwinding activity of eif-4f is located in the 46,000-dalton polypeptide of this complex , which has shown by others to be similar or identical to eif-4a . | NA | {
"id": "C0058989",
"name": "eif-4f",
"pos": [
56,
62
]
} | {
"id": "C0058984",
"name": "eif-4a",
"pos": [
181,
187
]
} |
the five class iii araar mutants which are adenosine-sensitive ( ados ) have various levels of adenosine kinase activity and produced two adenosine kinase polypeptides with similar mr as that of wild-type cells . | NA | {
"id": "C0042646",
"name": "araar",
"pos": [
19,
24
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
138,
147
]
} |
an araar mutant , ara-60a , with intermediate adenosine sensitivity , was shown to have two truncated adenosine kinase polypeptides . | NA | {
"id": "C0042646",
"name": "araar",
"pos": [
3,
8
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
102,
111
]
} |
the human sap gene is on chromosome 1 , probably closely linked to the gene for c-reactive protein which encodes the related acute phase reactant found in human plasma . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
80,
98
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
125,
145
]
} |
finally , the mass action ratio of the mitochondrial creatine kinase reaction exceeded the apparent equilibrium constant when atp was supplied to the creatine kinase reaction by oxidative phosphorylation . | NA | {
"id": "C0914594",
"name": "mitochondrial creatine kinase",
"pos": [
39,
68
]
} | {
"id": "C0010287",
"name": "creatine",
"pos": [
150,
158
]
} |
on comparing the titre levels in seroconverting children , the measles-antibody levels were found to be lower among older children , compared with younger , while the opposite was true for rubella . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
48,
56
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
116,
130
]
} |
by providing greater stability , this method extends the indications for intramedullary nailing to severely comminuted , oblique , and spiral fractures as well as to fractures complicated by loss of bone and fractures in the proximal and distal ends of the femoral shaft . | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
108,
118
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
208,
217
]
} |
of fifty-two patients with forty-nine severely comminuted fractures of the femoral shaft and three fractures that were complicated by loss of bone , forty-seven patients had uneventful consolidation of the fracture , with a mean time of 4.5 months for the severely comminuted fractures and seven months for the fractures that had a loss of bone . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
58,
66
]
} | {
"id": "C0476171",
"name": "comminuted fractures",
"pos": [
265,
285
]
} |
our radiological criteria for instability included dorsal angulation of more than 20 degrees , fractures involving the joint , radial shortening of more than 10 mm , and severe dorsal comminution . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
95,
104
]
} | {
"id": "C0476171",
"name": "comminution",
"pos": [
184,
195
]
} |
intravenous cloxacillin or flucloxacillin and benzylpenicillin were given in hospital for 48 hours and oral antibiotics and immobilisation were then continued at home for six weeks . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
12,
23
]
} | {
"id": "C0016267",
"name": "flucloxacillin",
"pos": [
27,
41
]
} |
eighteen had stable angina , 10 unstable angina , 2 post-myocardial infarction angina , and 4 had a severe concomitant disease . | NA | {
"id": "C0340288",
"name": "stable angina",
"pos": [
13,
26
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
79,
85
]
} |
eighteen had stable angina , 10 unstable angina , 2 post-myocardial infarction angina , and 4 had a severe concomitant disease . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
32,
47
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
79,
85
]
} |
there have been three subsequent pregnancies , two of which were first trimester miscarriages and one uneventful term delivery of a normal infant . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
33,
44
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
65,
80
]
} |
purified antibodies from an antiserum against s-phase proteins of the myxomycete physarum polycephalum were attached to protein-a-sepharose cl-4b . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
9,
19
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
28,
37
]
} |
we have characterized the association of the intermediate filament protein , vimentin , with the plasma membrane , using radioiodinated lens vimentin and various preparations of human erythrocyte membrane vesicles . | NA | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
45,
74
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
141,
149
]
} |
h36 is present on both skeletal and cardiac cells but absent from a variety of cells that include fibroblasts , neuronal cells , and smooth muscle . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
44,
49
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} |
in cow anterior pituitary , growth hormone and prolactin can be packed in separate granules of the same cell . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
7,
25
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
28,
42
]
} |
the x5x6x7 fraction is not digested by pepsin at 30 degrees c owing to its high thermal stability ( certainly explained by its high hydroxyproline + proline content ) . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
132,
146
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
149,
156
]
} |
irreversible damage which progresses to gangrenous necrosis of all or part of the colon holds an important share of the postoperative death rate . | NA | {
"id": "C0017086",
"name": "gangrenous",
"pos": [
40,
50
]
} | {
"id": "C0027540",
"name": "necrosis",
"pos": [
51,
59
]
} |
ribosomal proteins which bound 5s rrna at 0.3 m potassium chloride and were eluted at 1 m potassium chloride were identified as proteins 1 , l4 , 2/3 , l14/l16 , and s1 , s2 , s3 , s4 , s5 , by two-dimensional polyacrylamide gel electrophoresis . | NA | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
0,
9
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
128,
136
]
} |
this subset , while containing some of the proteins bound by 5s rrna columns , was distinctly different from the latter subset , indicating that the binding to 5s rrna was specific for that rna species . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
64,
68
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
190,
193
]
} |
after extraction of thiotepa and its metabolite , triethylenephosphoramide ( tepa ) , from plasma using sep-pak c18 cartridges , the compounds were separated by capillary chromatography , detected using a nitrogen detector and quantified by reference to an internal standard , hexaethylphosphoramide . | NA | {
"id": "C0039871",
"name": "thiotepa",
"pos": [
20,
28
]
} | {
"id": "C0039533",
"name": "triethylenephosphoramide",
"pos": [
50,
74
]
} |
analytical recoveries were 74 and 95 % , for tepa and thiotepa , respectively , in the therapeutic range . | NA | {
"id": "C0039533",
"name": "tepa",
"pos": [
45,
49
]
} | {
"id": "C0039871",
"name": "thiotepa",
"pos": [
54,
62
]
} |
separations were obtained under pressure ramped conditions using long ( 15 m ) 50-micron i.d . columns for several trichothecenes ( diacetoxyscirpenol , deoxynivalenol , and t-2 toxin ) and related higher molecular weight macrocyclic ( roridin and verrucarin ) trichothecenes . | NA | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
174,
183
]
} | {
"id": "C0040952",
"name": "trichothecenes",
"pos": [
261,
275
]
} |
ratios of low density lipoprotein-cholesterol/hdl-c and of apo b/apo a-1 were related positively with other coronary artery disease risk factors except in children having low levels of both beta-lpc and pre-beta-lpc . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
34,
45
]
} | {
"id": "C0023826",
"name": "pre-beta-lpc",
"pos": [
203,
215
]
} |
the method of iodotyrosine coupling described here may be useful to investigate the coupling step of thyroid hormone formation in human thyroid diseases . | NA | {
"id": "C0021996",
"name": "iodotyrosine",
"pos": [
14,
26
]
} | {
"id": "C0040135",
"name": "thyroid hormone",
"pos": [
101,
116
]
} |
additionally , we measured urinary cortisol and estriol excretion and circulating levels of dehydroepiandrosterone sulfate , estradiol , estrone , melatonin , norepinephrine , epinephrine , and dopamine during the control , fasting , and refeeding periods . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
159,
173
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
176,
187
]
} |
the diurnal rhythms of plasma epinephrine and norepinephrine were investigated in a group of normal young men . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
46,
60
]
} |
our results indicate that circadian variations in the sympathetic-adrenal medullary system are not explained by a single controlling influence and that the norepinephrine rhythm can be accounted for as a direct response to changes in posture and sleep , whereas the epinephrine rhythm is probably controlled by a circadian oscillator . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
266,
277
]
} |
in addition , the 107k protein includes at least two antigen epitopes and different patients have different antibodies or different populations of antibodies against these epitopes . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
53,
60
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
172,
180
]
} |
epithelial cell [ 3h ] leucine incorporation into protein was paradoxically enhanced by dexamethasone plus megestrol acetate compared to the latter alone , despite the fact that tissue dht and circulating adrenal androgens , dehydroepiandrosterone sulfate and delta 4-androstenedione , were not significantly different from values obtained after treatment with megestrol acetate alone . | NA | {
"id": "C0025175",
"name": "megestrol",
"pos": [
107,
116
]
} | {
"id": "C0065879",
"name": "megestrol acetate",
"pos": [
361,
378
]
} |
relative to albumin , both cbg and tebg were excluded from low chloride cysts , whereas relative to one another , the ratios of these two steroid-binding proteins were the same as those in plasma . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
12,
19
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
154,
162
]
} |
with only three exceptions in the latter group , cross-reactive antibodies were removed by absorption , thereby producing serogroup-specific antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
64,
74
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
141,
149
]
} |
eighteen unrelated children ( 12 boys and six girls ) with osgood-schlatter disease ( osd ) were evaluated by history , physical examination , and histocompatibility antigen [ human leukocyte antigen ( hla ) ] determination . | NA | {
"id": "C0019628",
"name": "histocompatibility antigen",
"pos": [
147,
173
]
} | {
"id": "C0019629",
"name": "human leukocyte antigen",
"pos": [
176,
199
]
} |
superimposed upon this normal background , sickle rbc filtrates are enriched with all proteins ( including cytoskeletal protein bands 1 , 2 , 2.1 , and 4.1 ) , suggesting a generalized oxidative perturbation of sickle rbc membranes . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
86,
94
]
} | {
"id": "C0010852",
"name": "cytoskeletal protein",
"pos": [
107,
127
]
} |
contrary to these observations , lipid-laden smc demonstrated a significant 50 % loss in chol and ce after treatment with nifedipine , due in part to the observed increase in ce hydrolytic activities . | NA | {
"id": "C0008377",
"name": "chol",
"pos": [
89,
93
]
} | {
"id": "C0008387",
"name": "ce",
"pos": [
175,
177
]
} |
these data support our hypothesis that nifedipine decreases chol and ce accumulation in arterial smc by increasing arterial ce hydrolysis . | NA | {
"id": "C0008377",
"name": "chol",
"pos": [
60,
64
]
} | {
"id": "C0008387",
"name": "ce",
"pos": [
124,
126
]
} |
autacoids ( principally histamine , beta adrenergic catecholamines , and prostaglandins e and a ) have only recently been recognized as substantive moderators of a number of immune functions . | NA | {
"id": "C0037343",
"name": "autacoids",
"pos": [
0,
9
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
24,
33
]
} |
sodium hypochlorite or hypochlorous acid produced by human peripheral blood neutrophils and trapped in the form of taurine chloramine were both found to be capable of producing free radicals from chlorpromazine , aminopyrine , and phenylhydrazine . | NA | {
"id": "C0037518",
"name": "sodium",
"pos": [
0,
6
]
} | {
"id": "C0020600",
"name": "hypochlorous acid",
"pos": [
23,
40
]
} |
omps from the pulmonary isolate inhibited bactericidal antibody activity directed against the isolate in both nhs ( 1.5 microgram of antigen ) and immune serum ( 0.75 microgram of antigen ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
55,
63
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
147,
159
]
} |
although the most phyletically ubiquitous of the known neurohypophysial peptides , avt is still not recognized as a mammalian hormone . | NA | {
"id": "C0032017",
"name": "neurohypophysial peptides",
"pos": [
55,
80
]
} | {
"id": "C0042418",
"name": "avt",
"pos": [
83,
86
]
} |
the studies presented here show that the in vitro addition of bovine milk lipoprotein lipase ( lipase ) to chylomicrons in the presence of human erythrocytes or fibroblasts ( and bovine serum albumin [ bsa ] ) resulted in the hydrolysis of the triglyceride and the transfer of both fatty acids and tocopherol to the cells ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
161,
172
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
316,
321
]
} |
a 22-year-old mildly retarded male , diagnosed as epileptic and paranoid schizophrenic , was admitted to an inpatient behavior unit for a medication assessment and possible behavioral treatment of uncontrolled seizure-like behavior . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
50,
59
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
210,
217
]
} |
the chemical stabilities of metronidazole ( in water ) and ten antibiotics ( ampicillin , carbenicillin , cefamandole , cefazolin , cefoxitin , moxalactam , nafcillin , penicillin g , piperacillin , and ticarcillin ) in 5 % dextrose injection ( except ampicillin which was in 0.9 % sodium chloride ) with magnesium sulphate were studied at 25 degrees c . | NA | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
90,
103
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
169,
181
]
} |
the chemical stabilities of metronidazole ( in water ) and ten antibiotics ( ampicillin , carbenicillin , cefamandole , cefazolin , cefoxitin , moxalactam , nafcillin , penicillin g , piperacillin , and ticarcillin ) in 5 % dextrose injection ( except ampicillin which was in 0.9 % sodium chloride ) with magnesium sulphate were studied at 25 degrees c . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
169,
181
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
252,
262
]
} |
the chemical stabilities of metronidazole ( in water ) and ten antibiotics ( ampicillin , carbenicillin , cefamandole , cefazolin , cefoxitin , moxalactam , nafcillin , penicillin g , piperacillin , and ticarcillin ) in 5 % dextrose injection ( except ampicillin which was in 0.9 % sodium chloride ) with magnesium sulphate were studied at 25 degrees c . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
184,
196
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
252,
262
]
} |
their cellular and sub-cellular localisations were investigated by double labelling immunofluorescence and immunogold electron microscopy , which showed that the expression of ca and hmfg2 antigens was closely associated on cell membranes but that the epitopes were distinct . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
189,
197
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
252,
260
]
} |
at concentrations of greater than 10 microm , gdp , gtp and a non-hydrolyzable gtp analogue , guanosine 5'- ( beta-gamma-imino ) triphosphate ( gpp ( nh ) p ) , inhibited the enzyme . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
52,
55
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
144,
156
]
} |
forestomach and whole tract digestibility of cellulose , hemicellulose , and lignin averaged 56.1 , 52.0 , 14.7 , and 58.7 , 58.5 , and 16.8 . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
45,
54
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
77,
83
]
} |
three commercial gold dental alloys and three ternary ( au-ag-cu ) alloys of constant nobility were subjected to a standardized test battery for tarnish . | NA | {
"id": "C0018027",
"name": "gold",
"pos": [
17,
21
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
67,
73
]
} |
three commercial gold-based dental alloys and three constant-nobility ternary alloys ( au-ag-cu ) were evaluated for corrosion using a quantitative test battery . | NA | {
"id": "C0018027",
"name": "gold",
"pos": [
17,
21
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
78,
84
]
} |
all fluoride dentifrices resulted in significant fluoride deposition , although significantly greater deposition was observed with a naf-sio2 dentifrice . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
4,
12
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
133,
136
]
} |
during propafenone treatment , 12 patients still had ventricular tachycardia induced , and the tachycardia cycle length significantly increased from 236 +/- 44 to 374 +/- 103 ms ( p less than 0.001 ) . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
53,
76
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
95,
106
]
} |
ten patients were considered to have satisfactory electrophysiologic response to propafenone on the basis of either the inability to initiate ventricular tachycardia or a marked increase in ventricular tachycardia cycle length associated with lack of symptoms during the induced tachycardia . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
142,
165
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
279,
290
]
} |
in the absence of a more complete knowledge of precise mechanisms , the efforts of the physician should be directed toward behavior modifications that appear to reduce the clinical manifestations of coronary heart disease which contribute to the development of cardiomegaly and myocardial ischemia . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
261,
273
]
} |
in many studies that carefully and specifically examined the prognostic importance of angina in relation to other variables , neither the presence of angina nor its severity was of prognostic significance , although a few studies suggested that the unstable form of angina may have unfavorable prognostic significance independent of the state of left ventricular function or the severity of coronary atherosclerosis . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
86,
92
]
} | {
"id": "C0002965",
"name": "unstable",
"pos": [
249,
257
]
} |
changes in the extrinsic sympathetic chain ( left stellate ganglion ) and in the prevailing vagal cardiac plexus were found in subjects with arrhythmias ( with long qt interval and ventricular tachycardia/fibrillation , respectively ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
141,
152
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
181,
192
]
} |
associated with the increased water , there was a parallel increase in na+ and k+ ions , with no overall change in intracellular cation concentration . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
82,
86
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
129,
135
]
} |
gastrin phosphorylation is observed only when a tpk is expressed by the cell : extracts of fibroblasts infected with a temperature-sensitive mutant of the rous sarcoma virus had no gastrin kinase activity when grown at the non-permissive temperature whereas cells grown at the permissive temperature were transformed and disclosed a clear gastrin kinase activity . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
91,
102
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
258,
263
]
} |
intravenous ( i.v . ) injection of 4 micrograms kg-1 bacterial endotoxin ( lps ) in intact rabbits evoked with short latency an increase in metabolic rate and the typical cardiorespiratory activity pattern normally seen in cold defense , consisting of cutaneous vasoconstriction , a depression of respiratory rate and , as shown in a previous study , a decrease in renal sympathetic nerve activity while heart rate and arterial blood pressure is little altered . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
63,
72
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
75,
78
]
} |
noradrenaline and serotonin nerve endings may facilitate the vasodepressor component of the baroreflex while adrenaline nerves possibly inhibit the cardiovagal mechanism . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
109,
119
]
} |
our in vitro studies on vessels from normally innervated hearts confirmed previous studies and showed that in large vessels , alpha and beta epinephrine or norepinephrine responses can be demonstrated ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
141,
152
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
156,
170
]
} |
the alpha effect is dominant and epinephrine is a more potent alpha agonist than is norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
33,
44
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
84,
98
]
} |
experimental arthrotomography including posteroanterior and lateral projections was completed in 18 fresh-frozen wrists from cadavers with an average age of 65 years at death . | NA | {
"id": "C0006629",
"name": "cadavers",
"pos": [
125,
133
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
169,
174
]
} |
affected animals ( oc/oc ) exhibit the characteristic radiologic and histologic hallmarks of osteopetrosis including a generalized increase in skeletal density and absence of marrow cavities . | NA | {
"id": "C0029464",
"name": "oc",
"pos": [
19,
21
]
} | {
"id": "C0029454",
"name": "osteopetrosis",
"pos": [
93,
106
]
} |
this unique constellation of features suggests that the oc mutation is a valuable model in which to investigate the pathogenesis of osteopetrosis . | NA | {
"id": "C0029464",
"name": "oc",
"pos": [
56,
58
]
} | {
"id": "C0029454",
"name": "osteopetrosis",
"pos": [
132,
145
]
} |
in cultured fibroblasts , it is distributed equally between the dorsal and ventral cell surfaces shortly after plating , but appears to become concentrated on the ventral surface as cell spreading proceeds ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
12,
23
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
182,
186
]
} |
a monoclonal antibody ( clone s-30 ) , directed to a protein of 57,000 daltons , was developed from the fusion of mouse myeloma cells and the spleen cells of mice injected with cytoskeletal extracts of fibroblasts that have been aged in in vitro culturing conditions according to a schedule of serial passaging ( cristofalo vj , charpentier r : j tissue culture meth 6:117 , 1981 ; | NA | {
"id": "C0007634",
"name": "the",
"pos": [
100,
103
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
202,
213
]
} |
these results suggest that the s-30 antibody can be used as a marker for nonproliferating cells both in cultured fibroblasts and in some tissues . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
90,
95
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
113,
124
]
} |
in 40 patients with conjunctivitis or keratoconjunctivitis povidone-iodine eye drops were either administered alone or in combination with a cortisone preparation . | NA | {
"id": "C0009763",
"name": "conjunctivitis",
"pos": [
20,
34
]
} | {
"id": "C0022573",
"name": "keratoconjunctivitis",
"pos": [
38,
58
]
} |
at room temperature , urinary excretion of epinephrine , but not norepinephrine or dopamine , was increased significantly in four-week-old shrsp and shrsr rats compared with age-matched wky . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} |
in addition , the epinephrine response was significantly enhanced in shrsp rats and the norepinephrine , epinephrine and dopamine responses were significantly enhanced in shrsr rats . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
88,
102
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
105,
116
]
} |
specifically , macrophage-activating factor ( maf ) , interferon-gamma ( ifn-gamma ) , or picogram amounts of endotoxin ( lps ) induced lfa-1 on tg-elicited macrophages following overnight incubation . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
110,
119
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
122,
125
]
} |
the region of gp-bp recognized by lewis t cells was additionally defined to include the 75-80 amino acid sequence , because a t cell clone responded equally to gp and rat bp which differed by only one amino acid at position 79 , but did not respond to human or bovine bp , which had a gly-his insertion in this region . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
94,
104
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
285,
288
]
} |
these observations suggest that in eamg , and perhaps in myasthenia gravis , the characteristics of the individual antibodies making up the autoimmune response can determine the severity of the autoimmune disease . | NA | {
"id": "C0752087",
"name": "eamg",
"pos": [
35,
39
]
} | {
"id": "C0026896",
"name": "myasthenia",
"pos": [
57,
67
]
} |
anti-p19 antibodies alpha htlv-2 , 3 , and 4 all reacted with the same htlvi p19 identified both by antibodies in htlvi+ patient sera and by antisera raised against two synthetic peptides encoded by the p19 gag region of htlvi . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
9,
19
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
141,
149
]
} |
serial transfer of spleen cells immune to allogeneic or semi-allogeneic cells induced transferable splenomegaly and general immune deficiencies , including the lack of proliferative responses to t and b cell mitogens and antibody responses to specific antigens . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
61,
77
]
} |
finally , we have been able to use anion exchange chromatography to prepare proteoglycan-enriched fractions to isolate the cspg . | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
76,
88
]
} | {
"id": "C0033689",
"name": "cspg",
"pos": [
123,
127
]
} |
this purification step has allowed us to convincingly demonstrate that the cspg can be labeled with amino acids , and is a necessary step for detecting amino acid-labeled cspg . | NA | {
"id": "C0033689",
"name": "cspg",
"pos": [
75,
79
]
} | {
"id": "C0033692",
"name": "cspg",
"pos": [
171,
175
]
} |
the results suggest that serine proteases are involved in both the induction of histamine release and desensitization , and that the protease involved in desensitization is distinct from that involved in triggering histamine release . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
25,
41
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
133,
141
]
} |
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