text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the lps-mediated loss of secretory function was both dose and time dependent and could be reproduced with the lipid a moiety of lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
110,
117
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
128,
131
]
} |
the role of granule membrane constituents has been elucidated with neutrophils disrupted by nitrogen cavitation and then fractionated in percoll gradients to resolve four postnuclear fractions : cytoplasm , light membranes or gamma fraction ( site of the nadph-oxidase ) , a light granule ( beta ) fraction containing putative constituents of the nadph-oxidase ( cytochrome b-245 and an associated flavoprotein ) , and a fraction of heavy granules . | NA | {
"id": "C0068355",
"name": "nadph-oxidase",
"pos": [
255,
268
]
} | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
398,
410
]
} |
thus , although all promastigotes from logarithmic ( log ) -phase cultures were agglutinated by the two-d-galactose-binding lectins , peanut agglutinin ( pna ) and ricinus communis , identical concentrations of these lectins failed to agglutinate approximately 50 % of l. major promastigotes from the stationary-phase cultures . | NA | {
"id": "C0607430",
"name": "galactose-binding lectins",
"pos": [
106,
131
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
217,
224
]
} |
complement-mediated serum cytotoxicity for leishmania major amastigotes : killing by serum deficient in early components of the membrane attack complex . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
0,
10
]
} | {
"id": "C0009545",
"name": "membrane attack complex",
"pos": [
128,
151
]
} |
the reactivity patterns of virus-specific ctl were assayed on target cells infected with hsv type 1 , strain kos , hsv type 2 , strain mueller , and mutants of hsv-1 ( kos ) antigenically deficient or altered in glycoproteins gc or gb , two of the four major hsv-1-encoded cell surface glycoprotein antigens . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
212,
225
]
} | {
"id": "C0025248",
"name": "cell surface glycoprotein",
"pos": [
273,
298
]
} |
an effective candidate subunit vaccine consisting of the gp 70/85 of feline leukemia virus ( felv ) was prepared by using the immunostimulating complex ( iscom ) method for the presentation of membrane proteins of enveloped viruses . | NA | {
"id": "C0887892",
"name": "subunit vaccine",
"pos": [
23,
38
]
} | {
"id": "C0085408",
"name": "iscom",
"pos": [
154,
159
]
} |
as determined by second antibody-colloidal gold , both antisera were found to decorate scrapie prion rods in purified preparations . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
24,
32
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
55,
63
]
} |
other melanoma-reactive mab of the same isotype as leo me13 did not block killing of melanoma cells , but one documented antibody , r24 , an igg3 with specificity for the ganglioside gd3 , was found to inhibit this function . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
24,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
121,
129
]
} |
other melanoma-reactive mab of the same isotype as leo me13 did not block killing of melanoma cells , but one documented antibody , r24 , an igg3 with specificity for the ganglioside gd3 , was found to inhibit this function . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
40,
47
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
121,
129
]
} |
in the presence but not the absence of priming antigen , ts inhibited the antigen-dependent proliferative response to the priming antigen as well as to heterologous antigens . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
47,
54
]
} | {
"id": "C0003333",
"name": "heterologous antigens",
"pos": [
152,
173
]
} |
a novel 'tandem ' immunoassay for the detection of mycobacterial antigen was devised using a monoclonal antibody ( ml 34 ) both as solid phase 'capture ' and as the 125i- or enzyme-labelled 'tracer ' antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
93,
112
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
200,
208
]
} |
no appreciable cross-reaction ( less than 0.05 % ) was observed with lh-rh and its analogs other than buserelin fragments ( 1.6-45 % ) . | NA | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
69,
74
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
102,
111
]
} |
these monoclonal antibodies can be easily purified and labelled and their defined specificities make it possible to select antibody combinations which provide the basis for 2-site immunometric assays for acth . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
6,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
123,
131
]
} |
the technique is especially useful ( 1 ) to determine the monoclonality of antibodies at an early stage in production , ( 2 ) to identify and classify antibodies having different structures but similar specificities , ( 3 ) to identify any alterations which may occur in quantity or quality of antibodies in long term culture , ( 4 ) to identify different hybridomas which produce antibodies of identical light chain subgroup . | NA | {
"id": "C0003250",
"name": "monoclonality",
"pos": [
58,
71
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
381,
391
]
} |
maximal keratinocyte adherence was obtained in wells precoated with 100 micrograms/ml fibronectin and when cells were incubated with substrate for 60 min or longer at 37 degrees c . | NA | {
"id": "C0022567",
"name": "adherence",
"pos": [
21,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} |
secondly , reduced degradation of the newly synthesized procollagen polypeptides may contribute to collagen deposition in some keloids . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
56,
67
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
99,
107
]
} |
the most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon omega-hydroxyacids and an ester-linked nonhydroxyacid , 41 % of which was linoleic acid . | NA | {
"id": "C0007745",
"name": "ceramides",
"pos": [
34,
43
]
} | {
"id": "C0002482",
"name": "amide",
"pos": [
78,
83
]
} |
cloned human papillomavirus ( hpv ) 11 and 16 dna were used as probes in southern blot hybridization at conditions of different stringency in order to determine viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
161,
166
]
} |
this property together with their well-known vasodilatory capabilities indicate that the leukotrienes of the slow-reacting substance of anaphylaxis may play a role in the vascular changes in the allergic-inflammatory reaction . | NA | {
"id": "C0023545",
"name": "leukotrienes",
"pos": [
89,
101
]
} | {
"id": "C0038091",
"name": "of",
"pos": [
133,
135
]
} |
the results also suggest that eba antibodies may be part of the autoantibody spectrum of sle and that separated skin is more sensitive than intact skin for their detection . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
34,
44
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
64,
76
]
} |
these additional malignant cell lines with their different sensitivities to alpha , beta , and gamma interferons may prove useful in studying the mechanisms of action of various interferons . | NA | {
"id": "C0021745",
"name": "gamma interferons",
"pos": [
95,
112
]
} | {
"id": "C0021747",
"name": "interferons",
"pos": [
178,
189
]
} |
basal surface autoradiography of [ 3h ] dthd-labeled , confluent , keratinocyte cultures reveals that proliferating cells have a nonrandom , patterned distribution . | NA | {
"id": "C0022567",
"name": "cultures",
"pos": [
80,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
116,
121
]
} |
antibodies to laminin and type iv collagen , both basement membrane-specific macromolecules , produced an intense staining pattern similar to that found with the anti-fibronectin antiserum , indicating that all 3 antigens are closely codistributed . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
179,
188
]
} |
of the gags isolated from the extracellular fraction , hypertrophic scar fibroblasts incorporated proportionately more 35s into chondroitin sulfate and less into heparan sulfate and more [ 3h ] glucosamine into hyaluronic acid than did normal skin fibroblasts . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
7,
11
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
162,
177
]
} |
of the gags isolated from the cellular fraction , hypertrophic scar fibroblasts incorporated proportionately more 35s into heparin and less into dermatan sulfate and more [ 3h ] glucosamine into hyaluronic acid than did normal skin fibroblasts . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
7,
11
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
123,
130
]
} |
of the gags isolated from the cellular fraction , hypertrophic scar fibroblasts incorporated proportionately more 35s into heparin and less into dermatan sulfate and more [ 3h ] glucosamine into hyaluronic acid than did normal skin fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
30,
38
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
232,
243
]
} |
dermatan sulfate ( ds ) was the major gag in each tissue and smaller quantities of chondroitin sulfate ( cs ) , heparan sulfate ( hs ) , and heparin ( hp ) were also present . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
38,
41
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
112,
127
]
} |
dermatan sulfate ( ds ) was the major gag in each tissue and smaller quantities of chondroitin sulfate ( cs ) , heparan sulfate ( hs ) , and heparin ( hp ) were also present . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
38,
41
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
141,
148
]
} |
cutaneous xenobiotic metabolizing enzymes including aryl hydrocarbon hydroxylase ( ahh ) , 7-ethoxycoumarin o-deethylase ( ecd ) , epoxide hydrolase ( eh ) and glutathione s-transferase ( gst ) activities were examined in skh hairless mice chronically irradiated with uvb to induce squamous cell carcinoma ( scc ) . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
52,
80
]
} | {
"id": "C0000644",
"name": "7-ethoxycoumarin o-deethylase",
"pos": [
91,
120
]
} |
basal ahh and ecd activities in microsomes from uvb-irradiated scc-bearing dorsal skin were 4.6- and 4.8-fold lower than those in dorsal skin of nonirradiated control animals . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
6,
9
]
} | {
"id": "C0000644",
"name": "ecd",
"pos": [
14,
17
]
} |
to study the ability of antibody to the core glycolipid ( cgl ) region of lipopolysaccharide ( lps ) to bind intact gram-negative bacterial cells , we produced monoclonal antibodies that bind lps from the escherichia coli rough mutant j5 . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
24,
32
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
160,
181
]
} |
in the course of prospective epidemiological studies of group b streptococcal ( gbs ) colonization and infection , we surveyed 401 paired maternal and cord sera ( obtained at delivery ) and 23 sera from patients with systemic type ii infection for igg antibody to gbs type ii . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
103,
112
]
} | {
"id": "C0243026",
"name": "systemic",
"pos": [
217,
225
]
} |
an automated , quantitative , cytopathic effect ( cpe ) inhibition assay with human fibroblasts in 96-well microtiter plates was used to examine the combination of recombinant human interferon-alpha ( rifn-alpha a ) and acyclovir , vidarabine , or dihydroxypropoxymethyl guanine against herpes simplex virus types 1 ( hsv-1 ) and 2 ( hsv-2 ) in vitro . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
220,
229
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
271,
278
]
} |
using light microscopy , the cells exhibit fibroblast-like morphology and accumulate lipids in their cytoplasm as the cultures become confluent . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
43,
53
]
} |
gel filtration of serum of mouse given an antibody to hcg showed that the antibody was forming immune complexes in the blood stream . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
42,
50
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
95,
111
]
} |
absence from sera from normal individuals or from rifampin-treated leprosy patients ( thelep trials ) of antibody to rifamycin-protein or rifamycin-membrane conjugates . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
50,
58
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
138,
147
]
} |
moreover , no antibodies to rifamycin-protein conjugates were found in sera from the patients included in thelep trials of six rifampin-containing regimens . | NA | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
28,
37
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
127,
135
]
} |
blood pressure changes produced by removal of the renal artery clip in two forms of experimental renovascular hypertension in the rat ( two-kidney one-clip and one-kidney one-clip hypertension ) have been studied in relation to sodium balance and the renin angiotensin system . | NA | {
"id": "C0020545",
"name": "renovascular hypertension",
"pos": [
97,
122
]
} | {
"id": "C0020544",
"name": "kidney",
"pos": [
164,
170
]
} |
an igm monoclonal antibody to plasma fn significantly inhibited fmlp-stimulated neutrophil attachment to gelatin , gelatin-fc , gelatin-fn , plastic , plastic-fc , and plastic-fn substrates when compared with the parent line myeloma supernatant or an irrelevant igm monoclonal antibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
18,
26
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
266,
285
]
} |
the purpose of this study was to measure the effects of music , progressive muscle relaxation ( pmr ) , and guided imagery ( gi ) on the adrenal corticosteroids , or `` '' stress hormones . '' '' | NA | {
"id": "C0001617",
"name": "adrenal corticosteroids",
"pos": [
137,
160
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
179,
186
]
} |
in contrast , their pups still showed rickets and osteomalacia , despite normal levels of 25-oh-d3 and calcium in the plasma . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
38,
45
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
50,
62
]
} |
the neurohypophysial hormones oxytocin and arginine vasopressin ( avp ) have been identified on immunological criteria in the ovary . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
4,
29
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
30,
38
]
} |
analysis by hplc indicated that the 1500 and 3000 mol . wt forms of ssli corresponded respectively to somatostatin-14 ( ss14 ) and somatostatin-28 ( ss28 ) whereas the 6000 and 10000 mol . wt forms eluted together as a composite peak of high molecular weight somatostatin ( hmw-ss ) . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
131,
146
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
259,
271
]
} |
the proportions of ss14 ( 63 % ) , ss28 ( 12 % ) and hmw-ss ( 25 % ) present in the hypothalamus were similar to those in the amygdala ( 59 , 9 and 32 % respectively ) . | NA | {
"id": "C0074854",
"name": "ss28",
"pos": [
35,
39
]
} | {
"id": "C0037659",
"name": "hmw-ss",
"pos": [
53,
59
]
} |
in contrast , the median eminence contained a greater proportion of ss28 than the other tissues : ss14 , ss28 and hmw-ss were present in the proportions 40 : 24 : 26 % . | NA | {
"id": "C0074854",
"name": "ss28",
"pos": [
68,
72
]
} | {
"id": "C0037659",
"name": "hmw-ss",
"pos": [
114,
120
]
} |
these results show that the rat median eminence differs from the hypothalamus as a whole in containing ss14 and ss28 in almost equimolar concentrations . | NA | {
"id": "C0037659",
"name": "ss14",
"pos": [
103,
107
]
} | {
"id": "C0074854",
"name": "ss28",
"pos": [
112,
116
]
} |
the effects of six natural vitamin d metabolites of potential biological and therapeutic interest , 1,25-dihydroxyvitamin d3 ( 1,25- ( oh ) 2d3 ) , 25-hydroxyvitamin d3 ( 25-oh-d3 ) , 24r,25-dihydroxyvitamin d3 ( 24r,25- ( oh ) 2d3 ) , 1,24r,25-trihydroxyvitamin d3 ( 1,24r,25- ( oh ) 3d3 ) , 25s,26-dihydroxyvitamin d3 ( 25s,26- ( oh ) 2d3 ) and 1,25s,26-trihydroxyvitamin d3 ( 1,25s,26- ( oh ) 3d3 ) on cell replication and expression of the osteoblastic phenotype in terms of osteocalcin production were examined in cultured human bone cells . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin",
"pos": [
148,
165
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
171,
179
]
} |
young children 's use of global magnitudes in classification also fits well with recent findings about children 's acquisitions of dimension words . | NA | {
"id": "C0728836",
"name": "young children 's",
"pos": [
0,
17
]
} | {
"id": "C0008059",
"name": "children 's",
"pos": [
103,
114
]
} |
while the effects of tricothecene mycotoxins have been described in domestic and experimental animals , there is a paucity of information about the pathologic effects of these toxins in humans . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
34,
44
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
176,
182
]
} |
the diagnosis of chronic pulmonary emphysema is simple with the sem even when dealing with autoptic material obtained 24 to 48 h after death , but the diagnosis of drowning becomes difficult in lungs with chronic emphysema . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
135,
140
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
164,
172
]
} |
the results obtained in the different groups of causes of death show that the biochemical parameters were modified postmortem although we think that this modification is related more directly to the duration of the pathological process that leads to death than with the nature of the process itself . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
215,
235
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
250,
255
]
} |
we have studied the block of potassium channels in voltage-clamped squid giant axons by nine organic and alkali cations , in order to learn how the channel selects among entering ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
112,
119
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
179,
183
]
} |
for alkali cations , the degree of hydration is probably crucial in determining how far an ion penetrates . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
11,
18
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
91,
94
]
} |
among the late proteins , which are generally structural proteins , 60 % of the nuclear proteins were tightly bound to the nuclear matrix . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
15,
23
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
80,
96
]
} |
in some cases ( e.g. , tyrosine hydroxylase , acetylcholine receptor , sodium channel ) these proteins have a known function , whereas most of these proteins ( e.g. , synapsin i ) had no known function when they were first identified as phosphoproteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
94,
102
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
237,
252
]
} |
clear distinction between the two activating processes was further confirmed by the facts that heparin- and cyclic amp-dependent phosphorylation stimulated th activity from k+-exposed ( and control ) tissues but not that from striatal slices incubated with forskolin ( or dibutyryl cyclic amp ) . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
108,
118
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic",
"pos": [
272,
288
]
} |
mouse oligodendroglioma cells , g-26 clone 20 and 24 , contain galactosylceramide ( cerebroside ) and sulfogalactosylceramide ( sulfatide ) as determined by an hplc technique . | NA | {
"id": "C0016960",
"name": "galactosylceramide",
"pos": [
63,
81
]
} | {
"id": "C0007805",
"name": "cerebroside",
"pos": [
84,
95
]
} |
monoclonal antibodies to rabbit brain acetylcholinesterase : selective enzyme inhibition , differential affinity for enzyme forms , and cross-reactivity with other mammalian cholinesterases . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
38,
58
]
} | {
"id": "C0008429",
"name": "cholinesterases",
"pos": [
174,
189
]
} |
the plant lectin concanavalin-a ( con-a ) reduced schwann cell pm 5'-ampase activity in a concentration-dependent manner ( 30-600 micrograms/ml ) . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
4,
16
]
} | {
"id": "C0009630",
"name": "concanavalin-a",
"pos": [
17,
31
]
} |
phylogenetic survey of proteins related to synapsin i and biochemical analysis of four such proteins from fish brain . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
23,
31
]
} | {
"id": "C0598294",
"name": "proteins",
"pos": [
92,
100
]
} |
polyadenylic-polyuridylic acid [ poly ( a ) x poly ( u ) ] , an immunomodulator , has been shown to have antitumor effects in rodents and in a randomized clinical trial as an adjuvant to surgery in patients with operable breast cancer . | NA | {
"id": "C0032402",
"name": "polyadenylic-polyuridylic acid",
"pos": [
0,
30
]
} | {
"id": "C0032400",
"name": "poly ( a",
"pos": [
33,
41
]
} |
levodopa-induced dyskinesia occurred less often in the group with preponderant tremor than in those with preponderant bradykinesia ( 29 % vs. 69 % ) . | NA | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
17,
27
]
} | {
"id": "C0040822",
"name": "tremor",
"pos": [
79,
85
]
} |
explantation of the catheter was not necessary in all patients in that embolic complications of the thrombosis were not observed , and the system was retained and functioned in five patients in spite of the presence of thrombosis around the catheter . | NA | {
"id": "C0085307",
"name": "embolic",
"pos": [
71,
78
]
} | {
"id": "C0040053",
"name": "thrombosis",
"pos": [
219,
229
]
} |
in patients receiving mitomycin c chemotherapy , the development of anemia and thrombocytopenia or azotemia may represent the initial manifestations of this newly defined thrombotic microangiopathy . | NA | {
"id": "C0040034",
"name": "thrombocytopenia",
"pos": [
79,
95
]
} | {
"id": "C2717961",
"name": "thrombotic microangiopathy",
"pos": [
171,
197
]
} |
26 patients with astrocytoma grade ii-iii , and 36 with malignant glioma ( astrocytoma grade iv or glioblastoma ) were submitted three days after surgery to a cycle of combination chemotherapy , including bcnu , vcr , pcz ( bvp ) . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
17,
28
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
99,
111
]
} |
the muscarinic receptors that modulate acetylcholine release from rat cortical synaptosomes were characterized with respect to sensitivity to drugs that act selectively at m1 or m2 receptor subtypes , as well as to changes in ionic strength and membrane potential . | NA | {
"id": "C0034826",
"name": "muscarinic receptors",
"pos": [
4,
24
]
} | {
"id": "C0384752",
"name": "m2 receptor",
"pos": [
178,
189
]
} |
at operation these tumors closely resembled cerebellar astrocytomas , presenting as a big cyst contiguous with the lateral ventricle and containing a small mural nodule . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
19,
25
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
90,
94
]
} |
the aim of this study was to determine whether positron emission tomography ( pet ) with fluorine-18 ( 18f ) -2-deoxyglucose ( fdg ) can be used as a prognostic test in patients with high-grade cerebral gliomas , regardless of the treatment given . | NA | {
"id": "C0011501",
"name": "2-deoxyglucose",
"pos": [
110,
124
]
} | {
"id": "C0046056",
"name": "fdg",
"pos": [
127,
130
]
} |
this injury model reduces the sources of variability found in other experimental compression trauma models and permits the quantitative assessment of basic spinal cord mechanisms and correlated histopathological changes in the same preparation following trauma . | NA | {
"id": "C0332679",
"name": "compression",
"pos": [
81,
92
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
254,
260
]
} |
the accuracy of radionuclide angiography and blood-pool imaging using [ 99mtc ] -phosphate to assess skin ulcer perfusion as an indicator of healing capacity was determined in 50 studies performed on 45 patients with nonhealing ulcers of the lower extremities . | NA | {
"id": "C0037299",
"name": "skin ulcer",
"pos": [
101,
111
]
} | {
"id": "C0023223",
"name": "ulcers of",
"pos": [
228,
237
]
} |
concentrations of glycine , serine , proline , glutamic acid plus glutamine and delta-aminovaleric acid were significantly higher in the lacto-ovo-vegetarians than in the controls . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
47,
60
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
66,
75
]
} |
the relative biological value of thiamin in leavened bread ( whole wheat and thiamin-restored white ) and thiamin mononitrate was examined by using thiamin-deficient rats as the test model . | NA | {
"id": "C0039844",
"name": "thiamin mononitrate",
"pos": [
106,
125
]
} | {
"id": "C0039840",
"name": "thiamin",
"pos": [
148,
155
]
} |
compared to thiamin in thiamin mononitrate ( 100 % ) , the biological value of thiamin in breads measured 88 % ( white bread ) and 91 % ( whole wheat bread ) based on etk activity and 68 % ( white bread ) and 75 % ( whole wheat bread ) based on liver thiamin response . | NA | {
"id": "C0039844",
"name": "thiamin mononitrate",
"pos": [
23,
42
]
} | {
"id": "C0039840",
"name": "thiamin",
"pos": [
251,
258
]
} |
ingested lipids undergo intestinal emulsification , digestion , micellar solubilization , cell membrane permeation , intracellular esterification and incorporation into lipoproteins before release to the interstitial fluid . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
9,
15
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
169,
181
]
} |
all diets were kept isonitrogenous by the addition of diammonium citrate , and lysine was supplied as l-lysine acetate . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
79,
85
]
} | {
"id": "C0024339",
"name": "lysine acetate",
"pos": [
104,
118
]
} |
the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin ( tcdd ) on the uptake , distribution and excretion of a single oral dose of [ 11,12-3h ] retinyl acetate and on the vitamin a status in the rat . | NA | {
"id": "C0073109",
"name": "retinyl acetate",
"pos": [
140,
155
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
167,
176
]
} |
pretreatment with a single low dose of tcdd thus affects both storage and excretion of radioactivity from newly administered ra as well as the vitamin a content in several tissues . | NA | {
"id": "C0073109",
"name": "ra",
"pos": [
65,
67
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
143,
152
]
} |
the finding of increased prevalence of respiratory symptoms among hot end workers was consistent with this exposure . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
4,
11
]
} | {
"id": "C0037090",
"name": "respiratory symptoms",
"pos": [
39,
59
]
} |
the majority of fractures were sustained by males and resulted from trauma inflicted in altercations . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
16,
25
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
68,
74
]
} |
we have been developing a model system for the study of human squamous epithelial cell differentiation , and among a panel of monoclonal antibodies we have generated for analysing this system are two antibodies recognizing subsets of epidermal keratins . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
126,
136
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
200,
210
]
} |
currently recommended initial therapy consists of a penicillin and an aminoglycoside , usually ampicillin and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
70,
84
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
110,
120
]
} |
an increase in hypothalamic mhpg sulphate concentration similar to that caused by pergolide was found after injection of quinpirole , a 'partial ergoline ' that is a selective d2 agonist not affecting alpha-adrenoceptors , and by ( - ) -n-propylnorapomorphine , a dopamine agonist not related to the ergolines . | NA | {
"id": "C0031007",
"name": "pergolide",
"pos": [
82,
91
]
} | {
"id": "C0014699",
"name": "ergolines",
"pos": [
300,
309
]
} |
8-phenyltheophylline was an apparently competitive antagonist of the negative chronotropic effect of adenosine , 2-chloroadenosine , l-n6-phenyl-isopropyl adenosine ( l-pia ) and 5'-n-ethylcarboxamide adenosine ( neca ) on atria and of the relaxant effect of adenosine , 2-chloroadenosine and neca on the aorta . | NA | {
"id": "C0050789",
"name": "5",
"pos": [
179,
180
]
} | {
"id": "C0001443",
"name": "neca",
"pos": [
293,
297
]
} |
8-phenyltheophylline was an apparently competitive antagonist of the negative chronotropic effect of adenosine , 2-chloroadenosine , l-n6-phenyl-isopropyl adenosine ( l-pia ) and 5'-n-ethylcarboxamide adenosine ( neca ) on atria and of the relaxant effect of adenosine , 2-chloroadenosine and neca on the aorta . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
113,
130
]
} | {
"id": "C0001443",
"name": "neca",
"pos": [
293,
297
]
} |
the enantiomers of the benzothiadiazines penflutizide ( 2a ) and bendroflumethiazide ( 2b ) in high optical purity , as well as enriched ( + ) -buthiazide ( 2j ) were obtained by repeated chromatography on a semipreparative scale . | NA | {
"id": "C0005084",
"name": "benzothiadiazines",
"pos": [
23,
40
]
} | {
"id": "C0004975",
"name": "bendroflumethiazide",
"pos": [
65,
84
]
} |
it has been claimed by other investigators that norepinephrine does not evoke a significant alpha adrenergic inotropic effect in human atria in contrast to epinephrine and phenylephrine , indicating a limitation of a possible functional role of the cardiac alpha adrenoceptors . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
48,
62
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
156,
167
]
} |
the ability of 5-hydroxytryptamine ( 5-ht ) and related agonists to stimulate hydrolysis of inositol phospholipids was examined in rat cerebral cortex slices using a direct assay which involves prelabeling with [ 3h ] inositol and assaying [ 3h ] inositol phosphates in the presence of lithium . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
92,
100
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
247,
266
]
} |
in contrast , the butyrophenone derivative , spirodecanone , displaced with equal potency all [ 3h ] spiroperidol from each of the six brain regions . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
18,
31
]
} | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
101,
113
]
} |
a type iii gold alloy , a silver-palladium alloy , and a base metal alloy were cast in two different centrifugal casting machines . | NA | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
11,
21
]
} | {
"id": "C0002154",
"name": "alloy",
"pos": [
68,
73
]
} |
the longlasting signal generated by the covalent msh-receptor complex was readily and reversibly abolished by adrenaline , noradrenaline , dopamine or clonidine or by the absence of calcium . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
110,
120
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
123,
136
]
} |
in spite of the functional independence of the ion pathways , several divalent cations inhibit rb+ and cl isotopic exchange as well as the h+ efflux that is dependent on either k+ or anion ( cl , scn , no2 ) fluxes . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
21,
24
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
183,
188
]
} |
this paper presents an experimental study and a theoretical interpretation of the effects of thallous ion on the electrical properties of the cation-selective channel of the sarcoplasmic reticulum ( sr channel ) . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
71,
74
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
142,
148
]
} |
extrachromosomal dna forms of copia-like transposable elements , f elements and middle repetitive dna sequences in drosophila melanogaster . | NA | {
"id": "C0012868",
"name": "transposable elements",
"pos": [
41,
62
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
98,
101
]
} |
drosophila melanogaster embryos and cells in culture were screened for the presence of unintegrated covalently closed circular dna forms that hybridize to copia-like transposable elements , the f element and uncharacterized dispersed middle repetitive dna elements . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
118,
130
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
252,
255
]
} |
drosophila melanogaster embryos and cells in culture were screened for the presence of unintegrated covalently closed circular dna forms that hybridize to copia-like transposable elements , the f element and uncharacterized dispersed middle repetitive dna elements . | NA | {
"id": "C0012868",
"name": "transposable elements",
"pos": [
166,
187
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
252,
255
]
} |
the conformational change elicited in cap by the class d analogs was further investigated by : ( 1 ) sensitivity to the proteolytic enzymes chymotrypsin , staphylococcus aureus v8 protease , subtilisin and trypsin ; | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
120,
139
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
180,
188
]
} |
addition of gtp to the gpp ( nh ) p-activated soluble adenylate cyclase complex leads to a decrease of the enzymatic activity . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
12,
15
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
23,
35
]
} |
this process presumably occurs via substitution of gpp ( nh ) p for gtp in the n-protein with subsequent hydrolysis of gtp and not by exchange of the n-protein-gpp ( nh ) p complex for the n-protein-gtp complex within the catalytic component of adenylate cyclase . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
51,
63
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
199,
202
]
} |
these cells produced cb3 virus continuously over several months , indicating carrier state infection of human myocardial fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
121,
132
]
} |
naf sensitivity was reconstituted in c by nonactivated and naf-activated preparations of g/f isolated by gel filtration . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
0,
3
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
109,
110
]
} |
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