text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
forskolin , however , augmented naf-sensitivity by both non-activated and naf-activated g/f provided it was added to the assay before g/f . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
32,
35
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
136,
137
]
} |
the p site agent 2',5'-dideoxyadenosine ( dda ) was a weak inhibitor of nonactivated c , but a powerful inhibitor of c stimulated by forskolin or activated by g/f in the presence of naf . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
70,
71
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
182,
185
]
} |
coma , commonly known as `` '' being unconscious '' '' or `` '' out cold , '' '' is a state of consciousness characterized by a total inability to perceive incoming stimuli . | NA | {
"id": "C0009421",
"name": "coma",
"pos": [
0,
4
]
} | {
"id": "C0041657",
"name": "unconsciou",
"pos": [
37,
47
]
} |
to construct a nondefective ad5 bearing the 2.8-kb dna fragment of hepatitis b virus ( hbv ) at this site , we deleted the 2.1-kb nonessential e3 fragment from cloned dna covering the right one-fourth of the ad5 genome ( 76 to 100 map units ) , inserted the hbv dna into this site , ligated the recombinant dna to the rest of the ad5 genome , and transfected the ligated dna into human embryo kidney cells . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
295,
310
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
371,
374
]
} |
icp8 bound ss dna fivefold more efficiently than ds dna , and both binding activities were most efficient in 150 mm nacl . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
11,
17
]
} | {
"id": "C0012854",
"name": "ss dna",
"pos": [
11,
17
]
} |
two lines of evidence indicate that the binding activities were not identical : ( i ) ds dna failed to complete with ss dna binding even with a large excess of ds dna ; | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
117,
123
]
} | {
"id": "C0012854",
"name": "ds dna",
"pos": [
160,
166
]
} |
( ii ) scatchard plots of dna binding with various amounts of dna were fundamentally different for ss dna and ds dna . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
99,
105
]
} | {
"id": "C0012854",
"name": "ds dna",
"pos": [
110,
116
]
} |
the next potential initiator codon predicted by the sequence is followed by 10 codons and then a termination codon . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
79,
85
]
} | {
"id": "C0242611",
"name": "termination",
"pos": [
97,
108
]
} |
antibodies capable of blocking the monoclonal antibodies were detected in the human sera , and the inhibition of binding correlated with the histories of herpetic infections . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
35,
56
]
} |
this 5.8-kilobase-pair f-mulv dna was joined to the ampho envelope gene and ltr creating a hybrid viral dna , f/a e+l . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
30,
33
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
98,
107
]
} |
a second hybrid viral dna , f/fr env , was made by joining the 5.8-kilobase-pair f-mulv dna to the fr-mcf envelope gene plus the f-mulv ltr . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
16,
25
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
88,
91
]
} |
chemical composition of the lesional lipid by elemental analysis and infrared absorption spectroscopy revealed paraffin hydrocarbon . | NA | {
"id": "C0030415",
"name": "paraffin",
"pos": [
111,
119
]
} | {
"id": "C0020242",
"name": "hydrocarbon",
"pos": [
120,
131
]
} |
field desorption mass spectrometric analysis showed the paraffin to be a mixture of saturated hydrocarbons containing substantially 24 to 40 carbon atoms . | NA | {
"id": "C0030415",
"name": "paraffin",
"pos": [
56,
64
]
} | {
"id": "C0020242",
"name": "hydrocarbons",
"pos": [
94,
106
]
} |
of the patients 27 per cent had significant bacteriuria ( more than 10 ( 5 ) per ml . ) , 38 per cent had significant pyuria ( more than 10 white blood cells per high power field ) , 19 per cent had urinary tract infection and 7 per cent had symptomatic urinary tract infection . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
44,
55
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
254,
277
]
} |
of the patients 27 per cent had significant bacteriuria ( more than 10 ( 5 ) per ml . ) , 38 per cent had significant pyuria ( more than 10 white blood cells per high power field ) , 19 per cent had urinary tract infection and 7 per cent had symptomatic urinary tract infection . | NA | {
"id": "C0034359",
"name": "pyuria",
"pos": [
118,
124
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
254,
277
]
} |
all 12 patients with symptomatic urinary tract infection had significant bacteriuria and 11 had significant pyuria , while 1 had 5 to 10 white blood cells per high power field . | NA | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
33,
56
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
73,
84
]
} |
all 12 patients with symptomatic urinary tract infection had significant bacteriuria and 11 had significant pyuria , while 1 had 5 to 10 white blood cells per high power field . | NA | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
33,
56
]
} | {
"id": "C0034359",
"name": "pyuria",
"pos": [
108,
114
]
} |
among the patients with chronic glomerulonephritis no significant differences were seen in frequencies of bacteriuria and urinary tract infection between male and female patients or between those who did and did not undergo hemodialysis . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
106,
117
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
122,
145
]
} |
two studies of brucellosis in wildlife on farms where the brucellosis infection prevalence in cattle was known are reported . | NA | {
"id": "C0006309",
"name": "brucellosis",
"pos": [
15,
26
]
} | {
"id": "C0302363",
"name": "brucellosis",
"pos": [
58,
69
]
} |
plasma prolactin level and plasma renin activity were determined in normal subjects and patients with low and normal renin essential hypertension , renal hypertension , renovascular hypertension , primary aldosteronism , cushing syndrome , pheochromocytoma and malignant hypertension . | NA | {
"id": "C0020544",
"name": "renal",
"pos": [
148,
153
]
} | {
"id": "C0020545",
"name": "renovascular hypertension",
"pos": [
169,
194
]
} |
hypoparathyroidism is known to exhibit various neurological manifestations , but most of the neurological disorders seen in this condition are motor ones , and involuntary movement is rarely encountered . | NA | {
"id": "C0027854",
"name": "neurological manifestations",
"pos": [
47,
74
]
} | {
"id": "C0027765",
"name": "neurological disorders",
"pos": [
93,
115
]
} |
the inhibition constant ( ki ) of hbp for the site of 3h-dexamethasone ( 3h-dm ) binding was approximately equal to the value of dm and significantly smaller than that of hydrocortisone ( hc ) . | NA | {
"id": "C0063076",
"name": "hbp",
"pos": [
34,
37
]
} | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
171,
185
]
} |
hbp and hydrocortisone 17-butyrate ( hb ) bound to other binding sites of hc in addition to the site for dm . | NA | {
"id": "C0063076",
"name": "hbp",
"pos": [
0,
3
]
} | {
"id": "C0020268",
"name": "hc",
"pos": [
74,
76
]
} |
furthermore , the first phase of hbp in the inhibition curve of 3h-hc binding disappeared from the curve , and only the second phase remained following the addition of dm . | NA | {
"id": "C0063076",
"name": "hbp",
"pos": [
33,
36
]
} | {
"id": "C0020268",
"name": "hc",
"pos": [
67,
69
]
} |
some characterization of the responses to substance p and other tachykinins in rabbit iris sphincter muscle . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
42,
53
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
64,
75
]
} |
contractile responses to substance p , physalaemin and eledoisin , three members of the tachykinin family , were compared and characterized in rabbit iris sphincter smooth muscle . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
25,
36
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
88,
98
]
} |
the difference between responses to eledoisin and to the other peptides , substance p and physalaemin , may suggest the existence of two different receptor subtypes for tachykinins in rabbit iris sphincter smooth muscle . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
74,
85
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
169,
180
]
} |
the rank orders of the inhibition of 3h-prazosin binding to the membrane preparations of the aorta expressed as ic50 ( the concentration of drugs inhibiting 50 % of maximal specific binding of 3h-prazosin ) were : prazosin greater than ym09538 greater than phentolamine greater than yohimbine greater than phenoxybenzamine greater than labetalol greater than s-596 greater than dibenamine greater than k-351 greater than propranolol greater than hydralazine greater than n-696 for alpha-blockers and i-epinephrine greater than clonidine greater than i-norepinephrine greater than phenylephrine greater than i-isoproterenol for agonists . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
502,
513
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
552,
566
]
} |
the effects of riboflavin deficiency on the metabolism of n-nitrosodimethylamine [ ( dmn ) cas : 62-75-9 ] and other nitrosamines were examined in rats . | NA | {
"id": "C0012431",
"name": "dmn",
"pos": [
85,
88
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
117,
129
]
} |
during mild deficiency , which was observed mainly with sprague-dawley rats , the microsomal dmn demethylase ( dmnd ) activity was elevated 30-80 % , but the metabolism of n-nitrosomethylbenzylamine ( cas : 937-40-6 ) and three other nitrosamines was slightly decreased . | NA | {
"id": "C0012431",
"name": "dmn",
"pos": [
93,
96
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
234,
246
]
} |
preincubation with flavin adenine dinucleotide and flavin mononucleotide enhanced the dmnd activity of the microsomes from riboflavin-deficient rats but not that from control rats . | NA | {
"id": "C0016388",
"name": "flavin",
"pos": [
19,
25
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
123,
133
]
} |
dna radioactivity and quantitative estimation of autoradiographs with the use of [ 3h ] thymidine revealed a significant increase in dna content ( twofold ) and in the percentage of labeled neoplastic nuclei in mice treated with prl plus mca ( 48.50 % ) as compared to that in mice treated with mca alone ( 23.50 % ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
299,
300
]
} |
the rate of progression of early renal failure was evaluated in three groups of adult patients with renal disease of diverse etiology on dietary protein and phosphorus restriction ( about 0.6 g/kg of protein , 700 mg of phosphorus ) and in a control group of 22 patients with the same renal disease , retrospectively studied , on a free diet . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
137,
152
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
200,
207
]
} |
the occurrence of cupping of the optic disk , which is not present with purely vascular optic nerve diseases , and the location of visual field defects in low-tension glaucoma , which is similar to that in glaucoma simplex but different from vascular diseases , as well as the increased diurnal tension variations of diurnal tension curves compared to the normal population are all factors which indicate that low-tension glaucoma is not a purely vascular optic nerve disease , and that pressure-lowering therapy is necessary . | NA | {
"id": "C0152136",
"name": "low-tension glaucoma",
"pos": [
155,
175
]
} | {
"id": "C0029132",
"name": "optic nerve disease",
"pos": [
456,
475
]
} |
under the influence of alcohol 7 subjects with blood alcohol concentrations of over 1 0/00 had visual fields which were concentrically restricted to various degrees , with relative scotomata centrally to the concentric restriction . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
23,
30
]
} | {
"id": "C0684262",
"name": "blood alcohol",
"pos": [
47,
60
]
} |
an aggressive pannus does not appear to have been described before in this syndrome or related diseases . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
75,
83
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
95,
103
]
} |
phosphatidylinositol -- after phosphorylation to phosphatidylinositolphosphate and phosphatidylinositolbisphosphate -- appears to be hydrolyzed by specific phospholipases c generating 1-stearoyl-2-arachidonoyl-diglyceride . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
0,
20
]
} | {
"id": "C0071655",
"name": "phosphatidylinositolphosphate",
"pos": [
49,
78
]
} |
thus , a suppression of the kallikrein-kinin-prostaglandin system in patients with eh was found , and a decrease in blood pressure with an increment of urinary kallikrein , pge excretion , plasma immunoreactive 6-keto pgf1 alpha and inhibition of platelet aggregation in vivo by the administration of glandular kallikrein . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
45,
58
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
173,
176
]
} |
the plasma concentrations of adrenaline and noradrenaline were significantly higher in hypertensive than in normotensive subjects and were not markedly altered by the dietary changes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
29,
39
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
44,
57
]
} |
four of 38 tissue specimens did contain dna sequences homologous to cloned viral dna probes ; | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
40,
43
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
75,
84
]
} |
however , some antigen-negative cells were observed and were restricted to the g0/g1 phase demonstrating the antigenic heterogeneity of this tumor line . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
15,
22
]
} | {
"id": "C0003335",
"name": "antigenic",
"pos": [
109,
118
]
} |
antidepressant effect a ) antagonism of hypothermia caused by reserpine in mice b ) potentiation of yohimbine-induced toxicity in mice . | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
62,
71
]
} | {
"id": "C0724441",
"name": "induced",
"pos": [
110,
117
]
} |
after culture with 20-30 % autologous or allogeneic t cells and pha , at least a proportion of the pathological cells from a variety of b-cell proliferations ( common acute lymphoblastic leukaemia , prolymphocytic leukaemia , non-hodgkin 's lymphoma with blood involvement by mature lymphoid ( cleaved and non-cleaved ) cells ) expressed true endogenous sheep erythrocyte ( e ) receptors . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
41,
51
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
320,
325
]
} |
the data are compatible with studies of cell and tissue grafts that have indicated an intrinsic haemopoietic stem cell defect in w/wv mice and an extrinsic , microenvironmental defect in s1/s1d mice . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
40,
44
]
} | {
"id": "C0018956",
"name": "haemopoietic stem cell",
"pos": [
96,
118
]
} |
in all cases , the recombinant human il-2 had the same activity as purified murine il-2 . | NA | {
"id": "C0218986",
"name": "recombinant",
"pos": [
19,
30
]
} | {
"id": "C0021756",
"name": "il-2",
"pos": [
83,
87
]
} |
furthermore , this new activity is specific to il-3 , since other colony-stimulating factors , i.e. , granulocyte-macrophage colony-stimulating factor ( gm-csf ) and l cell-derived colony-stimulating factor ( l-csf ) , do not induce it . | NA | {
"id": "C0021757",
"name": "il-3",
"pos": [
47,
51
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
181,
206
]
} |
binding of 125i-labelled epidermal growth factor per mg of cell protein similarly showed no difference between senescent and confluent mid-passage fibroblasts , although sparse mid-passage cells bound more of the ligand . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
147,
158
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
189,
194
]
} |
to determine whether potential differences in cytoskeletal proteins develop with progressive subcultivation , early and late passage cultures were extracted with 0.5 % triton x-100 for 1 min followed by 1.0 % sodium dodecyl sulfate ( sds ) prior to separation and characterization of extracted proteins by electrophoresis on 7.5-15 % gradient sds gels . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
46,
67
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
294,
302
]
} |
to determine whether potential differences in cytoskeletal proteins develop with progressive subcultivation , early and late passage cultures were extracted with 0.5 % triton x-100 for 1 min followed by 1.0 % sodium dodecyl sulfate ( sds ) prior to separation and characterization of extracted proteins by electrophoresis on 7.5-15 % gradient sds gels . | NA | {
"id": "C0058632",
"name": "dodecyl sulfate",
"pos": [
216,
231
]
} | {
"id": "C0037506",
"name": "sds",
"pos": [
343,
346
]
} |
the longitudinal smooth muscle of guinea pig ileum contains three different types of oxidative deaminating enzymes : monoamine oxidase types a and b , diamine oxidase and a soluble clorgyline-deprenyl-resistant benzylamine oxidase . | NA | {
"id": "C0026454",
"name": "monoamine oxidase",
"pos": [
117,
134
]
} | {
"id": "C0005105",
"name": "benzylamine oxidase",
"pos": [
211,
230
]
} |
methionine synthase activity was more thiol-dependent in the patient 's fibroblasts than it was in normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
99,
111
]
} |
we studied the different effects of three kinds of somatostatin ( somatostatin 1-14 , somatostatin 15-28 , somatostatin 1-28 ) on the aggregation of rabbit 's platelets . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
51,
63
]
} | {
"id": "C0074854",
"name": "somatostatin",
"pos": [
107,
119
]
} |
it was clarified that somatostatin 15-28 had inhibitory effects on rabbit 's platelet aggregation stronger than somatostatin 1-14 did , and that somatostatin 1-28 did not have any such effects . | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
22,
34
]
} | {
"id": "C0074854",
"name": "somatostatin",
"pos": [
145,
157
]
} |
we have pharmacologically characterized voltage sensitive calcium channels ( vsccs ) in gh3 cells , an anterior pituitary clonal cell line known to secrete prolactin and growth hormone . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
103,
121
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
170,
184
]
} |
further , the novel dihydropyridine vscc agonists , bay k8644 and cgp 28392 , enhanced 50 mm k+-stimulated 45ca2+ uptake and these effects were blocked by nitrendipine . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
20,
35
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
155,
167
]
} |
displacement studies of [ 3h ] - [ d-ala2-mephe4-gly-ol5 ] -enkephalin ( [ 3h ] -dago ) and [ 3h ] - [ d-ala2-d-leu5 ] -enkephalin ( [ 3h ] -dadl ) by the corresponding unlabeled ligands show that there are at least three classes of sites which bind these enkephalin analogs with high affinity . | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
81,
85
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
256,
266
]
} |
fresh milk samples collected with 20 volumes chloroform-methanol ( 1:1 , v/v ) were analogous in total free fatty acid level and profile of fatty acids to a duplicate sample collected with 0.4m edta and immediately frozen at -10 c . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
103,
118
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
140,
151
]
} |
significantly different fatty acid profile and higher levels of free fatty acids in milk collected without a lipase inhibitor added indicate that domestic freezing and/or thawing ruptures the fat globule membrane , allowing sn-1-stereospecific serum stimulated lipoprotein lipase contact with its triglyceride substrate . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
24,
34
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
64,
80
]
} |
in some instances , for the treatment of medical pieces made of carbon steels chromizing is advisable rather than electroplating and chemical-conversion plating as well as the use of stainless steels . | NA | {
"id": "C0038239",
"name": "steels",
"pos": [
71,
77
]
} | {
"id": "C0038126",
"name": "stainless steels",
"pos": [
183,
199
]
} |
production of rt3 from t4 in the placenta were measured in four patients with induced abortion , in three patients with spontaneous abortion , in 19 patients with various complications of pregnancy including graves ' disease , and in 18 normal pregnancies . | NA | {
"id": "C0000786",
"name": "spontaneous abortion",
"pos": [
120,
140
]
} | {
"id": "C0032962",
"name": "complications of pregnancy",
"pos": [
171,
197
]
} |
retinyl esters were used as markers of chylomicrons and chylomicron remnants since they are carried mainly if not exclusively by lipoproteins of intestinal origin . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
39,
51
]
} | {
"id": "C0443616",
"name": "chylomicron remnants",
"pos": [
56,
76
]
} |
retinyl esters were used as markers of chylomicrons and chylomicron remnants since they are carried mainly if not exclusively by lipoproteins of intestinal origin . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
39,
51
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
129,
141
]
} |
the majority of subjects with mild or moderate hypertriglyceridemia ( predominantly type iv hyperlipoproteinemia ) also had elevated plasma concentrations of retinyl esters . | NA | {
"id": "C0020557",
"name": "hypertriglyceridemia",
"pos": [
47,
67
]
} | {
"id": "C0020480",
"name": "type iv hyperlipoproteinemia",
"pos": [
84,
112
]
} |
this androgen deficiency seemed to be a consequence of decreased gonadotropin output rather than primary testicular failure , since both pituitary gonadotropin content and serum gonadotropin levels ( basally and after luteinizing hormone releasing factor ; lhrh ) were reduced in nephrotic rats . | NA | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
65,
77
]
} | {
"id": "C0018066",
"name": "pituitary gonadotropin",
"pos": [
137,
159
]
} |
however , gonadotropin output in nephrotic rats was not impaired in the absence of testis , since no reduction was seen in either post-castration serum gonadotropin levels in vivo or gonadotropin release from pituitaries incubated in vitro . | NA | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
10,
22
]
} | {
"id": "C0018066",
"name": "gonadotropin",
"pos": [
183,
195
]
} |
the location of 5.8s , 18s and 28s rrna coding regions was established by dna-rna hybridization and s1 nuclease mapping . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
35,
39
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
78,
81
]
} |
tyler first suspected this ten years ago when his head was jerked back from his infant son 's cot by the pungent odour of ammonia gas . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
122,
129
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
130,
133
]
} |
model of anion and monovalent cation transport as neutral ion pairs through lipophilic water channels of the na , k atpase complex . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
9,
14
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
58,
61
]
} |
cations and anions form neutral ion pairs or undissociated acids at these sites and then partition much more favorably into lipophilic channel water , passing through the channel in diffusive fashion . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
0,
7
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
196,
199
]
} |
cations and anions form neutral ion pairs or undissociated acids at these sites and then partition much more favorably into lipophilic channel water , passing through the channel in diffusive fashion . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
12,
18
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
196,
199
]
} |
strong adjuvanticity of bacterial lipopolysaccharides possessing the homopolysaccharides consisting of mannose as the o-specific polysaccharide chains . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
34,
53
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
118,
143
]
} |
by 360 min . after endotoxin injection : ( a ) the rate of increase in free amino acid levels in the femoral artery was 366 mumole/l of alanine , 162 mumole/l of glycine and 85 mumole/l of proline ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
76,
86
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
136,
143
]
} |
by 360 min . after endotoxin injection : ( a ) the rate of increase in free amino acid levels in the femoral artery was 366 mumole/l of alanine , 162 mumole/l of glycine and 85 mumole/l of proline ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
76,
86
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
162,
169
]
} |
( b ) the rate of increase in free amino acid of the quadriceps femoris muscle was 1376 nmole/g of alanine , 156 nmole/g of glycine and 109 nmole/g of serine ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
35,
45
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
99,
106
]
} |
( b ) the rate of increase in free amino acid of the quadriceps femoris muscle was 1376 nmole/g of alanine , 156 nmole/g of glycine and 109 nmole/g of serine ; | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
35,
45
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
124,
131
]
} |
the results show the following : skeletal muscle appears to be an important source of amino acids for amino acid metabolism during endotoxemia , especially plasma alanine which is closely connected with alanine levels in skeletal muscle . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
86,
97
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
203,
210
]
} |
cytochrome p-450-dependent aryl hydrocarbon hydroxylase ( ahh ) and 7-ethoxycoumarin o-deethylase activities of a cloned line of human lymphoblastoid ahh-1 cells are inhibited by a monoclonal antibody ( mab 1-7-1 ) prepared to a 3-methylcholanthrene-induced rat liver cytochrome p-450 . | NA | {
"id": "C0000644",
"name": "7-ethoxycoumarin o-deethylase",
"pos": [
68,
97
]
} | {
"id": "C0003927",
"name": "ahh",
"pos": [
150,
153
]
} |
cytochrome p-450-dependent aryl hydrocarbon hydroxylase ( ahh ) and 7-ethoxycoumarin o-deethylase activities of a cloned line of human lymphoblastoid ahh-1 cells are inhibited by a monoclonal antibody ( mab 1-7-1 ) prepared to a 3-methylcholanthrene-induced rat liver cytochrome p-450 . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
58,
61
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
268,
284
]
} |
the monoclonal antibody inhibition determined that a single mab 1-7-1-sensitive type of cytochrome p-450 is responsible for all of ahh expression in both the basal and benz [ a ] anthracene-induced cells . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
88,
104
]
} | {
"id": "C0003927",
"name": "ahh",
"pos": [
131,
134
]
} |
partial inhibition by the mab 1-7-1 , however , indicates that at least two forms of cytochrome p-450 catalyze 7-ethoxycoumarin o-deethylase in both the basal and the induced cells , one form of which is identical to the mab-sensitive cytochrome p-450 responsible for all of the ahh . | NA | {
"id": "C0000644",
"name": "7-ethoxycoumarin o-deethylase",
"pos": [
111,
140
]
} | {
"id": "C0003927",
"name": "ahh",
"pos": [
279,
282
]
} |
partial inhibition by the mab 1-7-1 , however , indicates that at least two forms of cytochrome p-450 catalyze 7-ethoxycoumarin o-deethylase in both the basal and the induced cells , one form of which is identical to the mab-sensitive cytochrome p-450 responsible for all of the ahh . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
85,
101
]
} | {
"id": "C0003927",
"name": "ahh",
"pos": [
279,
282
]
} |
for the 7-x-2,3 , -dichlorodibenzo-p-dioxins , there was not a rank order correlation between receptor-binding ec50 values and the induction of aryl hydrocarbon hydroxylase ( ahh ) or ethoxyresorufin o-deethylase in rat hepatoma h-4-ii e cells in culture . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon",
"pos": [
144,
160
]
} | {
"id": "C0059735",
"name": "ethoxyresorufin o-deethylase",
"pos": [
184,
212
]
} |
furthermore , we demonstrate that phorbol ester ( 12-o-tetradecanoylphorbol-13-acetate ; tpa ) inhibits the effects of ara-c on heme production , accumulation of globin rna , and glycophorin expression . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
34,
47
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
50,
86
]
} |
the rotation functions for various aspartic proteases were calculated and combined results were used for the refinement of orientational parameters of chymosin molecules in the unit cell . | NA | {
"id": "C0078989",
"name": "aspartic proteases",
"pos": [
35,
53
]
} | {
"id": "C0035100",
"name": "chymosin",
"pos": [
151,
159
]
} |
unique single-stranded regions of simian virus 40 dna , phage m13 virion dna , and several homopolymers were used as templates for the synthesis of ( p ) pprna-dna chains by cv-1 cell dna primase-dna polymerase alpha . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
7,
22
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
196,
199
]
} |
nuclear factor i is a cellular site-specific dna-binding protein required for the efficient in vitro replication of adenovirus dna . | NA | {
"id": "C0069116",
"name": "nuclear factor i",
"pos": [
0,
16
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
45,
64
]
} |
these proteins ( p37/4.78 and p41/4.75 ) were identified as tropomyosins , a group of at least five cytoskeletal proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
100,
121
]
} |
we also found that even though monoclonal igg1 ab was able to bind strongly to a protein a-sepharose column and could be eluted only by a low-ph buffer , the purified ab , when bound to cell surface hapten , showed a weak ability to react with free protein a . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
31,
41
]
} | {
"id": "C0003241",
"name": "ab",
"pos": [
222,
224
]
} |
the determinant recognized by antibody eb2 was equally represented on hgh and met-hgh when assessed by a liquid-phase radioimmunoassay : however , measurement of the binding in a solid-phase assay resulted in a two-four-fold lower binding to met-hgh . | NA | {
"id": "C3714500",
"name": "hgh",
"pos": [
70,
73
]
} | {
"id": "C0143083",
"name": "binding",
"pos": [
231,
238
]
} |
three monoclonal antibodies ( mab ) , 21 ( igg1 ) , i10 ( igg1 ) and h38 ( igg2b ) , to insulin have been tested for cross-reactivity with 11 species variants of insulin and three of proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
88,
95
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
183,
193
]
} |
neither mab 21 nor mab h38 react with human or pig proinsulins respectively indicating that the presence of the c-peptide joining a1 to b30 masks the epitope . | NA | {
"id": "C0033362",
"name": "proinsulins",
"pos": [
51,
62
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
112,
121
]
} |
this release is greatly reduced by neutralisation of lipid a of lps with the antibiotic polymyxin b sulfate . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
53,
60
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
64,
67
]
} |
crude lipid a still retains its ability to induce tnf release but is significantly less effective than native lps molecules . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
6,
13
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
110,
113
]
} |
these results suggest that lipid a of lps molecule is important in causing lethality and tnf release in vivo while the polysaccharide portion may be involved in delivering the lipid a moiety to tnf-producing cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
38,
41
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
176,
183
]
} |
an anti-complementary polysaccharide , ar-arabinogalactan , was isolated from the roots of angelica acutiloba kitagawa ( japanese name = yamato-tohki ) , and purified by chromatography on deae-sephadex a-50 , sephadex g-100 , sepharose cl-2b and concanavalin a-sepharose . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
22,
36
]
} | {
"id": "C0036681",
"name": "sepharose",
"pos": [
261,
270
]
} |
it was -0.823 +/- 0.949 sd and -0.495 +/- 0.927 sd for children with birth weights below and above the 3rd percentile for birth weight resp. , and -1.285 +/- 1.031 and -1.261 +/- 1.069 sd for children whose length or length and weight were below the 3rd percentile at birth . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
69,
81
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
228,
234
]
} |
the baseline sister-chromatid exchanges ( sces ) and the percentage of first ( m1 ) , second ( m2 ) and third or higher metaphase ( m3+ ) chromosomes were analysed in bone-marrow cells of male and female c57bl/6 mice and chinese hamsters following serial intraperitoneal injections of 40 micrograms/g body weight ( b.w . ) of 5-bromo-2'-deoxyuridine ( brdurd ) and 2 micrograms/g b.w . of 5-fluorodeoxyuridine ( fdurd ) or 40 micrograms/g b.w . of brdurd and 10 micrograms/g b.w . of deoxycytidine ( dc ) . | NA | {
"id": "C0016343",
"name": "5-fluorodeoxyuridine",
"pos": [
389,
409
]
} | {
"id": "C0011535",
"name": "brdurd",
"pos": [
448,
454
]
} |
the distribution patterns of m1 , m2 and m3+ metaphases in brdurd/fdurd-treated animals differ significantly from those in brdurd/dc-treated animals . | NA | {
"id": "C0016343",
"name": "fdurd",
"pos": [
66,
71
]
} | {
"id": "C0011535",
"name": "brdurd",
"pos": [
123,
129
]
} |
in view of the high degree of qualitative correlation between mutagenic activity of chemicals in bacteria and in cultured mammalian cells , and their mutagenic and carcinogenic properties in animals , and in order to be able to distinguish whether mutagenic potency differences were due to differences in ( dna ) dose rather than other physiological factors , the results of mutagenicity tests obtained in the present experiments using bacteria and mammalian cells were compared on the basis of dna dose rather than exposure concentrations , with the following questions in mind : is there an absolute or a relative correlation between the mutagenic potencies of various ethylating agents in bacteria ( e. coli k12 ) and in mammalian cells ( v79 chinese hamster ) after treatment in standardized experiments , and can specific dna adducts be made responsible for mutagenicity ? | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
307,
310
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
827,
838
]
} |
the analysis suggested that the observed excess of discrete adenomatous polyps and colorectal cancers was the result of an inherited autosomal dominant gene for susceptibility , rather than an inherited recessive gene for susceptibility or a chance occurrence . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
161,
175
]
} | {
"id": "C0314657",
"name": "inherited",
"pos": [
193,
202
]
} |
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