text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
crude preparations of cytotoxins ( ctxs ) produced by human peripheral blood mononuclear cells exert a marked cytotoxic effect when applied to cells in the presence of cycloheximide but in its absence can induce resistance to cytotoxicity . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
60,
76
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} |
two substituted benzamides , flb 524 and raclopride , were labeled with 11c and examined for their possible use as ligands for positron emission tomography ( pet ) -scan studies on dopamine-2 ( d-2 ) receptors in the brains of monkeys and healthy human subjects . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
16,
26
]
} | {
"id": "C0072953",
"name": "raclopride",
"pos": [
41,
51
]
} |
sera from 46 chimpanzees with spongiform encephalopathy ( 18 kuru , 28 creutzfeldt-jakob disease ) and sera from 12 sheep with natural scrapie were tested for reactivity with immunoblots of neurofilament preparations obtained from mouse brain . | NA | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
30,
55
]
} | {
"id": "C0022802",
"name": "kuru",
"pos": [
61,
65
]
} |
sera from 46 chimpanzees with spongiform encephalopathy ( 18 kuru , 28 creutzfeldt-jakob disease ) and sera from 12 sheep with natural scrapie were tested for reactivity with immunoblots of neurofilament preparations obtained from mouse brain . | NA | {
"id": "C0162534",
"name": "spongiform encephalopathy",
"pos": [
30,
55
]
} | {
"id": "C0036457",
"name": "scrapie",
"pos": [
135,
142
]
} |
the antibodies to neurofilaments used here immunostain most or all of the neurofibrillary tangles present in the sections whereas the antiserum to microtubule protein immunoreacted with about half of the neurofibrillary tangles . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
134,
143
]
} |
the powerful stimulation of feeding elicited by this neuropeptide suggests an important role for hypothalamic npy , or a structurally related peptide , in the regulation of feeding behavior . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
53,
65
]
} | {
"id": "C0027893",
"name": "npy",
"pos": [
110,
113
]
} |
the wild-type lactose carrier of escherichia coli has a poor ability to transport the disaccharide maltose . | NA | {
"id": "C0022949",
"name": "lactose",
"pos": [
14,
21
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
86,
98
]
} |
the wild-type lactose carrier of escherichia coli has a poor ability to transport the disaccharide maltose . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
86,
98
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
99,
106
]
} |
in this step the lambda o and p initiators cooperate with the e. coli dnaj and dnak proteins to transfer the bacterial dnab protein onto m13 dna that is coated with the single-stranded dna-binding protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
84,
92
]
} | {
"id": "C0004627",
"name": "bacterial",
"pos": [
109,
118
]
} |
these results suggest that polyphosphoinositide breakdown in stimulated cells may occur via a cyclic phosphate intermediate , as has been described for phosphatidylinositol . | NA | {
"id": "C0071655",
"name": "polyphosphoinositide",
"pos": [
27,
47
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
152,
172
]
} |
the calcium binding protein of skeletal muscle sarcoplasmic reticulum ( also referred to as calsequestrin ) was purified by release from the compartment of the vesicles with the detergent octaethyleneglycol mono-n-dodecyl ether ( c12e8 ) and by subsequent precipitation of the calcium binding protein with specific divalent cations . | NA | {
"id": "C0006787",
"name": "calsequestrin",
"pos": [
92,
105
]
} | {
"id": "C0006732",
"name": "calcium binding protein",
"pos": [
277,
300
]
} |
distinct roles of putrescine and spermidine in the regulation of ornithine decarboxylase in neurospora crassa . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
18,
28
]
} | {
"id": "C0037871",
"name": "regulation",
"pos": [
51,
61
]
} |
direct addition of putrescine or spermidine to cycloheximide-treated cells confirmed the role of putrescine in enzyme inactivation and showed that spermidine had no effect on this process . | NA | {
"id": "C0037871",
"name": "cycloheximide",
"pos": [
47,
60
]
} | {
"id": "C0034170",
"name": "putrescine",
"pos": [
97,
107
]
} |
the amino acid composition , molecular mass , and nh2-terminal sequence of this amyloid protein are almost identical to those described for the amyloid deposited in the congophilic angiopathy of alzheimer disease and down syndrome , but the plaque core proteins have ragged nh2 termini . | NA | {
"id": "C1456454",
"name": "amyloid protein",
"pos": [
80,
95
]
} | {
"id": "C0002716",
"name": "amyloid",
"pos": [
144,
151
]
} |
inactivation occurred after a723u formed a reversible complex with the enzyme and only while the enzyme was catalyzing the formation of deoxynucleotides . | NA | {
"id": "C0026741",
"name": "complex",
"pos": [
54,
61
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
97,
103
]
} |
antibody titers to the epstein-barr virus ( ebv ) , early antigen ( ea ) igg , and virus capsid antigen ( vca ) igg and iga , were measured in 44 geriatric subjects to determine if the depression in cellular immunity known to be associated with aging affects the expression of latent ebv . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
58,
65
]
} | {
"id": "C0003342",
"name": "virus",
"pos": [
83,
88
]
} |
mass spectra ( ei ) of phenazone , aminophenazone , 4-aminophenazone , noramidopyrine , isopropyl-aminophenazone , niphenazone , propylphenazone and morazone are obtained . | NA | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
35,
49
]
} | {
"id": "C0002696",
"name": "4-aminophenazone",
"pos": [
52,
68
]
} |
this paper reports results of a study of circulating procaine levels in ten healthy volunteers who received 1.8 ml injections of 2 % procaine hydrochloride at a defined peri-oral site . | NA | {
"id": "C0033218",
"name": "procaine",
"pos": [
53,
61
]
} | {
"id": "C0358490",
"name": "procaine hydrochloride",
"pos": [
133,
155
]
} |
neither riboflavin nor riboflavin-5-phosphate competed for binding to the tcdd receptor in rat liver cytosol . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
8,
18
]
} | {
"id": "C0016388",
"name": "riboflavin-5-phosphate",
"pos": [
23,
45
]
} |
inhibition of metabolism of the 'nonclassical ' antifolate , trimetrexate ( 2,4-diamino-5-methyl-6- [ ( 3,4,5-trimethoxyanilino ) methyl ] quinazoline ) by drugs containing an imidazole moiety . | NA | {
"id": "C0085176",
"name": "trimetrexate",
"pos": [
61,
73
]
} | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
139,
150
]
} |
2,4-diamino-5-methyl-6- [ ( 3,4,5-trimethoxyanilino ) methyl ] quinazoline ( tmq ; nsc no . 249008 ) is a 'nonclassical ' antifolate which is advocated as an alternative to methotrexate . | NA | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
63,
74
]
} | {
"id": "C0085176",
"name": "tmq",
"pos": [
77,
80
]
} |
the ability of two drugs that antagonise the effects of benzodiazepines , cgs 8216 and ro 15-1788 , to reverse the effects of cl 218,872 and chlordiazepoxide were also investigated , to see whether their effects might be mediated via benzodiazepine receptors . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
56,
71
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
141,
157
]
} |
in monkeys trained to discriminate a 10-micrograms/kg dose of ekc from saline , the stimulus effects generalized completely to u-50488 and other kappa agonists ( e.g. , bremazocine , cyclazocine ) , but not to the pure mu agonists . | NA | {
"id": "C0079314",
"name": "ekc",
"pos": [
62,
65
]
} | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
183,
194
]
} |
the results are interpreted as showing that d-amphetamine facilitates tracking performance as a result of its action of enhancing response switching , and supporting the hypothesis that facilitation of performance by amphetamine-like drugs depends on the effect of the drug on response output coinciding with task requirements . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
44,
57
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
217,
228
]
} |
soft-tissue abnormalities of the eac that can be evaluated with ct include atresia , edema , hemorrhage , fracture , posttraumatic or infection-caused keloid , malignant external otitis , hemangioma , lymphangioma , papilloma , keratosis obturans , acquired cholesteatoma , adenoma , ceruminoma , fibroma , mixed tumor , sarcoma , and basal cell , squamous cell , or adenocystic carcinoma . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
274,
281
]
} | {
"id": "C0026277",
"name": "mixed",
"pos": [
307,
312
]
} |
thyroid dysgenesis is often manifested by a lingual or sublingual location of the thyroid gland . | NA | {
"id": "C1563716",
"name": "thyroid dysgenesis",
"pos": [
0,
18
]
} | {
"id": "C0266284",
"name": "sublingual",
"pos": [
55,
65
]
} |
the identity of this hete product was investigated using reverse phase high performance liquid chromatography ( rp-hplc ) and gas chromatography-mass spectrometry ( gc-ms ) and found to be predominantly 12-hydroxy-5,8,10,14-eicosatetraenoic acid ( 12-hete ) with a small amount of 15-hete . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
248,
255
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
284,
288
]
} |
quantitative estimation of the synthesized hemoglobin phenotypes , for the three indicated culture periods , showed preferential synthesis of hb f in addition to an overall increase in hemoglobin synthesis in pge2 treated colonies . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
43,
53
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
142,
146
]
} |
a radioimmunoassay ( ria ) was developed to measure fibroblast growth factor ( fgf ) using antiserum generated against a synthetic replicate of [ tyr10 ] fgf ( 1-10 ) . | NA | {
"id": "C0016026",
"name": "fgf",
"pos": [
79,
82
]
} | {
"id": "C0391318",
"name": "fgf",
"pos": [
154,
157
]
} |
forty patients scheduled for elective surgery of the hand-forearm region under axillary plexus block received mepivacaine carbonate or mepivacaine hydrochloride ( 1 % solution ) in a random fashion . | NA | {
"id": "C0025384",
"name": "mepivacaine",
"pos": [
110,
121
]
} | {
"id": "C0700542",
"name": "mepivacaine",
"pos": [
135,
146
]
} |
ct has been found to be extremely useful in the diagnosis of trauma and postoperative changes by its ability to demonstrate fractures , foreign bodies , haematomas , abscesses , soft tissue displacement or perforation of orbital structures , as well as showing prosthetic material . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
61,
67
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
124,
133
]
} |
ct has been found to be extremely useful in the diagnosis of trauma and postoperative changes by its ability to demonstrate fractures , foreign bodies , haematomas , abscesses , soft tissue displacement or perforation of orbital structures , as well as showing prosthetic material . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
61,
67
]
} | {
"id": "C0016542",
"name": "foreign bodies",
"pos": [
136,
150
]
} |
the adenine derivatives adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , adenosine 5'-monophosphate ( amp ) and adenosine ( ad ) , in concentrations of 10 ( -3 ) m and 10 ( -4 ) m caused significant and dose-related modifications in the basal acid secretion from isolated whole rat stomach . | NA | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
24,
35
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
95,
106
]
} |
the adenine derivatives adenosine 5'-triphosphate ( atp ) , adenosine 5'-diphosphate ( adp ) , adenosine 5'-monophosphate ( amp ) and adenosine ( ad ) , in concentrations of 10 ( -3 ) m and 10 ( -4 ) m caused significant and dose-related modifications in the basal acid secretion from isolated whole rat stomach . | NA | {
"id": "C0001459",
"name": "adenosine",
"pos": [
24,
33
]
} | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
95,
106
]
} |
the first three purine derivatives , atp , adp and amp significantly increased the spontaneous acid secretion . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
37,
40
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
51,
54
]
} |
the first three purine derivatives , atp , adp and amp significantly increased the spontaneous acid secretion . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
43,
46
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
51,
54
]
} |
when atp , adp , amp and ad were assayed in the presence of the adrenergic and cholinergic blocking agents , ergotamine , 10 ( -6 ) m , propranolol , 5 x 10 ( -7 ) m and atropine , 10 ( -6 ) m , all these purine derivatives , including ad , caused a significant increase in the basal acid secretion . | NA | {
"id": "C0001480",
"name": "atp",
"pos": [
5,
8
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
17,
20
]
} |
when atp , adp , amp and ad were assayed in the presence of the adrenergic and cholinergic blocking agents , ergotamine , 10 ( -6 ) m , propranolol , 5 x 10 ( -7 ) m and atropine , 10 ( -6 ) m , all these purine derivatives , including ad , caused a significant increase in the basal acid secretion . | NA | {
"id": "C0001459",
"name": "adp",
"pos": [
11,
14
]
} | {
"id": "C0001413",
"name": "amp",
"pos": [
17,
20
]
} |
the immobilising action of immobyl ( fentanyl : azaperone , 5:1 ) in six sheep has been analysed on the basis of the changes in dopamine , noradrenalin , adrenalin , homovanillic acid and 5-hydroxytryptamine concentrations in the corpus striatum , frontal motor cortex , pons , cerebellum and lumbosacral spinal cord as compared to the control animals which were given saline . | NA | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
139,
151
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
154,
163
]
} |
papillomavirus genome persisted in the transformed fibroblasts and was apparently not integrated with the cellular genome . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
106,
114
]
} |
the following parameters were determined : arm muscle surface , whole-body muscle mass , proportion of body fat , serum albumin ( alb ) , prealbumin ( pa ) , retinol-binding protein ( rbp ) , transferrin , thyroxine-binding protein , thyroxine , triiodothyronine , reverse triiodothyronine and total complement . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
114,
127
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
138,
148
]
} |
the pulmonary fibrosis observed in patients with dermatomyositis differs from that found in other connective tissue diseases in that it follows a more acute course and may respond to corticosteroids . | NA | {
"id": "C0011633",
"name": "dermatomyositis",
"pos": [
49,
64
]
} | {
"id": "C0009782",
"name": "connective tissue diseases",
"pos": [
98,
124
]
} |
after 11 years 95 % of those who seroconverted who were tested had hemagglutination-inhibiting ( hai ) antibodies and 100 % had neutralizing ( nt ) antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
103,
113
]
} | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
128,
140
]
} |
this was accompanied by parallel study of respiratory function tests and the level of bronchial reactivity to carbachol in asthma sufferers as well as other alveolar biological parameters : phospholipid fractions of surfactant , angiotensin conversion enzyme and protein/albumin ratio . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
263,
270
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
271,
278
]
} |
sds-polyacrylamide gel electrophoresis revealed either an increase in albumin and high molecular weight proteins alone or an increase in low and high molecular weight proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
70,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
167,
175
]
} |
two cases of rheumatoid arthritis with sjogren 's syndrome are reported which developed chronic myelocytic leukemia . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
13,
33
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
39,
58
]
} |
the relationships between these illnesses , rheumatoid arthritis and sjogren 's syndrome on the one hand , and a myeloproliferative disorder on the other hand , are discussed , as well as the possible role of the treatment regimens ( synoviorthesis with radio-isotopes in case number 1 ) . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
44,
64
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
69,
88
]
} |
conjugation , metabolism and excretion of [ 24-14c ] chenodeoxycholic acid in patients with extrahepatic cholestasis before and after biliary drainage-analysis of conjugated bile acids by hplc . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
14,
24
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
29,
38
]
} |
compared to the 25-year olds , the 50-year old men had more than three times higher basal plasma vasopressin ( 7.8 +/- 1.4 vs. 2.5 +/- 0.6 ng/l , p less than 0.01 ) , only one-third the plasma renin concentration ( 0.36 +/- 0.05 vs. 1.10 +/- 0.33 g.u . x 10 ( -4 ) /ml , p less than 0.01 ) and a significantly higher plasma noradrenaline ( 267 +/- 21 vs. 199 +/- 19 ng/l , p less than 0.05 ) while plasma adrenaline remained essentially unchanged . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
324,
337
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
405,
415
]
} |
with few exceptions , the greatest decrease was seen with solutions containing alcohol , i.e . chlorhexidine and isopropyl alcohol . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
79,
86
]
} | {
"id": "C0022237",
"name": "isopropyl alcohol",
"pos": [
113,
130
]
} |
microprobe elemental analysis might be used to differentiate one type from another on the basis of iron and possibly phosphorus ( for nucleated cells ) . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
11,
20
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
117,
127
]
} |
using coated specimens ( gold or gold-palladium ) precludes simultaneous visual mode sem with edx because of energy line interference with phosphorus and other elements . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
139,
149
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
160,
168
]
} |
the second population contained colony-forming cells derived from both fc-receptor positive and fc-receptor negative precursor cells , suggesting that at least some colonies in diffusion chambers arise from fc-receptor positive granulopoietic cells of intermediate maturity and/or monocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
117,
132
]
} |
2 patients with promyelocytic leukaemia ( m3 ) had low fibrinogen and ap , high fdp and normal at iii , speaking for primary fibrinolysis , which in addition to proteolytic enzymes in the blast cells are important contributing factors regarding mb in anll . | NA | {
"id": "C0023487",
"name": "promyelocytic leukaemia",
"pos": [
16,
39
]
} | {
"id": "C0023467",
"name": "anll",
"pos": [
251,
255
]
} |
complement activation determinations of gold-labelled antibodies or immune complexes showed that antibodies or immune complexes fixed on colloidal gold particles do not activate the complement . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
54,
64
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
111,
117
]
} |
in addition to the macrophage-like langerhans cells , keratinocytes within the epidermal cells have been shown to act as immunoregulatory cells through the secretion of cytokines such as epidermal cell-derived thymocyte-activating factor ( etaf ) and interleukin 3 . | NA | {
"id": "C0022567",
"name": "epidermal cells",
"pos": [
79,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
these findings demonstrate that the production of immunoregulatory cytokines is not confined to cells of the immune system and that keratinocytes through the production of etaf and ec il-3 may mediate inflammatory and hypersensitivity reactions . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
96,
101
]
} | {
"id": "C0022567",
"name": "etaf",
"pos": [
172,
176
]
} |
this study , performed on rheumatoid arthritis patients treated with auranofin , orally administered for 8-34 months , did not reveal any appreciable corneal deposits of gold . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
69,
78
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
170,
174
]
} |
amino acid and carbohydrate analyses of aposaa subfractions showed that they were non-glycosylated polypeptides rich in aspartic acid , glycine , glutamic acid , glutamine , and arginine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
136,
143
]
} |
amino acid and carbohydrate analyses of aposaa subfractions showed that they were non-glycosylated polypeptides rich in aspartic acid , glycine , glutamic acid , glutamine , and arginine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
146,
159
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
162,
171
]
} |
however , in the agar diffusion test the use of a penicillin disk may produce false-susceptible results , and therefore the susceptibility test should be performed with a disk containing oxacillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
50,
60
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
187,
196
]
} |
most of the nuclear genome of warm-blooded vertebrates is a mosaic of very long ( much greater than 200 kilobases ) dna segments , the isochores ; | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
116,
119
]
} | {
"id": "C1135894",
"name": "isochores",
"pos": [
135,
144
]
} |
the gene for the rna subunit ( m1 rna ) of ribonuclease p from salmonella typhimurium directs the synthesis of an rna that can cleave transfer rna precursor molecules . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
17,
20
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
134,
146
]
} |
the concentration in plasma of the female protein ( fp ) of the golden syrian hamster is regulated by sex steroids and by mediators of the acute-phase response to tissue injury or inflammation . | NA | {
"id": "C0001349",
"name": "acute-phase",
"pos": [
139,
150
]
} | {
"id": "C0021368",
"name": "inflammation",
"pos": [
180,
192
]
} |
the subset of proteins with which the igm antibodies are reactive includes a factor ( or factors ) capable of inhibiting lectin-induced t-lymphocyte proliferation . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
14,
22
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
121,
127
]
} |
the method offers rapid analysis of changes in the cellular content of rna and protein as well as in the rna-protein , rna-dna , and protein-dna ratios in relation to cell cycle position for large cell populations . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
79,
86
]
} | {
"id": "C0243021",
"name": "protein",
"pos": [
133,
140
]
} |
in addition to being taken up by pheochromocytomas , meta-iodobenzylguanidine may be used to image neuroblastomas , nonfunctioning paragangliomas , and carcinoid tumors . | NA | {
"id": "C0031511",
"name": "pheochromocytomas",
"pos": [
33,
50
]
} | {
"id": "C0030421",
"name": "paragangliomas",
"pos": [
131,
145
]
} |
the common underlying mechanism in the progression of senile scoliosis appears to be asymmetric loading of the spine which can be caused by a previously established scoliosis , spondylolysis/spondylolisthesis , lumbosacral anomalies , or leg length discrepancy . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
177,
190
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
191,
208
]
} |
the development of a method for rating cognitive responses to the diagnosis of early breast cancer , lymphoma and hodgkin 's disease is described in the context both of recent coping theory and a previous study by this unit relating outcome to response to diagnosis . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
101,
109
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
114,
132
]
} |
susceptibility and time-kill studies were done with low and high inocula of both beta-lactamase-positive and -negative strains of haemophilus influenzae with cefamandole , ampicillin , cefoperazone , mezlocillin , moxalactam , and ceftriaxone . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
158,
169
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
185,
197
]
} |
susceptibility and time-kill studies were done with low and high inocula of both beta-lactamase-positive and -negative strains of haemophilus influenzae with cefamandole , ampicillin , cefoperazone , mezlocillin , moxalactam , and ceftriaxone . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
172,
182
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
200,
211
]
} |
in contrast , cefamandole , mezlocillin , and ampicillin were less active against the low inoculum of beta-lactamase-positive h influenzae . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
28,
39
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
46,
56
]
} |
ampicillin , cefamandole , cefoperazone , and mezlocillin were rapidly inactivated by the high inoculum of beta-lactamase-positive h influenzae . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
0,
10
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
46,
57
]
} |
ampicillin , cefamandole , cefoperazone , and mezlocillin were rapidly inactivated by the high inoculum of beta-lactamase-positive h influenzae . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
13,
24
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
27,
39
]
} |
we have constructed interspecific somatic cell hybrids between a thymidine-auxotrophic mutant cell line of mouse fm3a cells that lacks thymidylate synthase and human diploid fibroblasts derived from a male patient with fragile x-linked mental retardation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
in the group i patients with a severe hepatitis b , bilirubinemia reached a maximum at the eleventh day of jaundice or later ( 71.4 % ) . | NA | {
"id": "C0020433",
"name": "bilirubinemia",
"pos": [
52,
65
]
} | {
"id": "C0022346",
"name": "jaundice",
"pos": [
107,
115
]
} |
to determine the antagonization of anticoagulant and lipolytic effects of a low molecular weight [ lmw ] heparin preparation protamine chloride was given intravenously after i.v . injection of lmw or normal heparin . | NA | {
"id": "C0019139",
"name": "low",
"pos": [
76,
79
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
207,
214
]
} |
the incomplete inhibitory effect of protamine chloride on lpl , htgl and factor xa activities of lmw heparin indicate that protamine chloride requires more than 14 saccharide units in the heparin molecule for interaction . | NA | {
"id": "C0019139",
"name": "lmw heparin",
"pos": [
97,
108
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
188,
195
]
} |
in addition , there is dissociation of some hla-d and -dr specificities , a number of panel members are positive for an hla-d specificity and are negative for the corresponding hla-dr specificity . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
44,
49
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
177,
183
]
} |
suppression of jh production by precocene prevented all foregoing nuclear changes , but re-exposure to methoprene rapidly induced normal development . | NA | {
"id": "C0022439",
"name": "jh",
"pos": [
15,
17
]
} | {
"id": "C0025674",
"name": "methoprene",
"pos": [
103,
113
]
} |
the high-iron diamine staining ( hid ) , which has been used in histochemistry to stain sulfated glycoconjugates ( sgc ) , was tested for detectability of authentic acidic substances ( chondroitin sulfates a plus c , dermatan sulfate , heparan sulfate , chondroitin , hyaluronic acid , alpha 1-acid glycoprotein and ribonucleic acid ) in electrophoresis on cellulose acetate membrane ( separax ) . | NA | {
"id": "C0008466",
"name": "chondroitin sulfates",
"pos": [
185,
205
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
254,
265
]
} |
the high-iron diamine staining ( hid ) , which has been used in histochemistry to stain sulfated glycoconjugates ( sgc ) , was tested for detectability of authentic acidic substances ( chondroitin sulfates a plus c , dermatan sulfate , heparan sulfate , chondroitin , hyaluronic acid , alpha 1-acid glycoprotein and ribonucleic acid ) in electrophoresis on cellulose acetate membrane ( separax ) . | NA | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
217,
233
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
254,
265
]
} |
of 174 cases with recent intracerebral hemorrhage , 19 presented with a lacunar syndrome : 4 presented with pure motor hemiparesis , 5 , ataxic hemiparesis , 3 , dysarthria-clumsy hand syndrome , 7 , sensorimotor stroke , and , none , pure sensory stroke . | NA | {
"id": "C3178801",
"name": "lacunar syndrome",
"pos": [
72,
88
]
} | {
"id": "C0038454",
"name": "stroke",
"pos": [
248,
254
]
} |
these observations suggests that hypertensive intracerebral hemorrhage causes lacunar syndrome more often than previously considered and is apt to manifest ataxic hemiparesis and sensorimotor stroke . | NA | {
"id": "C3178801",
"name": "lacunar syndrome",
"pos": [
78,
94
]
} | {
"id": "C0038454",
"name": "stroke",
"pos": [
192,
198
]
} |
cell-mediated immunity ( cmi ) was measured by blastic transformation of peripheral blood lymphocytes in 26 patients with amoebic liver abscess ( ala ) and matched control subjects with no demonstrable clinical amoebiasis . | NA | {
"id": "C0023886",
"name": "amoebic liver abscess",
"pos": [
122,
143
]
} | {
"id": "C0002438",
"name": "amoebiasis",
"pos": [
211,
221
]
} |
aggressive liver disease was observed in the vast majority of patients : 12 ultimately developed cirrhosis , ( mean follow-up 81 months ) , 6 chronic active hepatitis ( mean follow-up 93 months ) , 3 chronic persistent hepatitis ( mean follow-up 89 months ) , and in 1 patient the presence of hb virus in hepatocytes was the sole morphologic alteration ( follow-up 42 months ) . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
11,
24
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
97,
106
]
} |
analysis of the topography peculiarities and distribution of oxidized melanine and its precursors ( dopa-oxide activity and catecholamine ) in pigment nevuses and malignant melanomas of skin shows that the studied peculiarities are a complex of intersupplementary markers of melanine formation , correlate with the quality and the degree of proliferative process expression in tumours of this genesis and may be used for their malignancy rating . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
100,
104
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
124,
137
]
} |
it is shown that at the fixed total dna concentrations a complete replacement of the eukaryotic carrier dna for the plasmid dna , containing no tg gene of hsv1 , decreases but only insignificantly the frequency and efficiency of transformation . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
36,
39
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
238,
239
]
} |
in the boyden chamber assay sv 40 virus-transformed balb-c3t3 fibroblast ( sv/3t3 ) showed an increased chemotactic response to fibroblasts-conditioned medium in comparison to non-transformed balb/c3t3 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
128,
139
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
202,
207
]
} |
the content of creatine phosphate , creatine and creatine kinase activity in thymus is shown to be 17.6 , 5 and 4 times respectively higher , than in thymocytes isolated from this organ , both the level of adenine nucleotides and adenylate energy charge being practically the same . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
15,
33
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
49,
57
]
} |
the main indication for measuring urinary concentrations of this protein during aminoglycoside treatment is to compare the nephrotoxic potential of different aminoglycosides and possibly of other antimicrobial agents , e.g . cephalosporins . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
80,
94
]
} | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
196,
216
]
} |
these three cats had significantly higher mean blood glucose levels during the glucose tolerance test than did cats with impaired glucose tolerance and no insular amyloid deposits . | NA | {
"id": "C0020456",
"name": "higher",
"pos": [
35,
41
]
} | {
"id": "C0271650",
"name": "impaired glucose tolerance",
"pos": [
121,
147
]
} |
rats given sendai virus alone had mild , patchy , necrotizing rhinitis , laryngitis , tracheitis , and bronchitis , but not bronchiolitis or interstitial pneumonia . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
103,
113
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
124,
137
]
} |
the 24 hour urinary excretion of phenylbutazone and its hydroxylated metabolites , oxyphenbutazone and gamma-hydroxyphenylbutazone , accounted for approximately 25 per cent of the administered intravenous dose in both young and older ponies . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
33,
47
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
83,
98
]
} |
at the conclusion of the experiment , guinea pigs injected with the following adjuvants and ppv antigen : cp-20 961 ( avridin ) , 50 % aluminum hydroxide gel , ethylene maleic anhydride ( ema ) , oil and water emulsion ( o/w ) and dimethyl-dioctadecyl-ammonium bromide ( dda ) immunologically responded with high geometric mean hi titers ( 380 , 224 and 427 , 602 , 512 , 1202 respectively ) , whereas guinea pigs receiving emulsan , sodium dodecyl sulfate ( sds ) , l-121 , combinations of emulsan/aluminum hydroxide , sds/aluminum hydroxide and b . | NA | {
"id": "C0002372",
"name": "aluminum hydroxide gel",
"pos": [
135,
157
]
} | {
"id": "C0002371",
"name": "aluminum hydroxide",
"pos": [
524,
542
]
} |
apart from mononuclear elements such as monocytes , macrophages , and giant cells we observed fibroblast-like and myofibroblast-like cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
94,
104
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} |
the mean nuclear area of the trophoblast in a group of hydatidiform moles , followed by a trophoblastic malignancy , was found to be statistically significantly larger than that of the trophoblast in a group of hydatidiform moles which were not followed by malignant trophoblastic disease . | NA | {
"id": "C0020217",
"name": "hydatidiform moles",
"pos": [
55,
73
]
} | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
267,
288
]
} |
sv40 dna had no favourable effect on the evolution of the sv40-induced tumor , which suggests that viral dna does not represent the active component of the sv40 -- hs dna preparations . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
99,
108
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
167,
170
]
} |
after some considerations on terminology and on the classification of viral encephalitides , mention is made of the studies in the domain of herpes infections , rabies , meningitis , encephalitis and slow virus infections of the central nervous system ( subacute sclerosing panencephalitis , multiple sclerosis , amyotrophic lateral sclerosis , creutzfeldt-jakob disease , etc . ) . | NA | {
"id": "C0243010",
"name": "viral encephalitides",
"pos": [
70,
90
]
} | {
"id": "C0038522",
"name": "subacute sclerosing panencephalitis",
"pos": [
254,
289
]
} |
the major metabolite is the gamma-hydroxy derivative of phenylbutazone present both as the lactone and as the straight-chain compound , while oxyphenbutazone and p , gamma-dihydroxyphenylbutazone are minor metabolites . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
56,
70
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
142,
157
]
} |
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