text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the greater part of the indications were severe coronaritis resistant to medical treatment ( 54 percent ) with unstable angina or steady state angina , and valvulopathy ( 37 percent ) with prevalence of symptomatic aortic stenosis . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
111,
126
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
143,
149
]
} |
the effects of glucose and insulin in culture medium on the release and cellular content of beta-hexosaminidase were studied in fibroblast cultures obtained from patients with type ii diabetes and from control subjects . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
72,
80
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
128,
138
]
} |
of the 99 congenital defects with radiological findings there were six cases of osteochondrodysplasias , 16 cases of chromosomal malformation syndromes , 13 cases of autosomally recessively inherited malformation syndromes and 18 cases of multiple malformation syndromes of unknown aetiology . | NA | {
"id": "C0000768",
"name": "congenital defects",
"pos": [
10,
28
]
} | {
"id": "C0000772",
"name": "multiple malformation",
"pos": [
239,
260
]
} |
application of the inhibitory amino acid , glycine ( 7 micrograms ) , into the substantia nigra zona compacta ( snc ) simultaneously suppressed compacta neuronal discharges and enhanced cn activities . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
30,
35
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
43,
50
]
} |
since descending monoaminergic pathways play an important part in the endogenous pain control system , a phase of monoamine depletion could open the pain gate and give rise to headache . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
81,
85
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
176,
184
]
} |
electronystagmogram examination of patients with transient ischaemic attacks or infarcts in the carotid and vertebrobasilar system revealed significantly increased number of patients with reduced caloric response , abnormal optokinetic nystagmus , saccadic dysmetria and presence of central nystagmus in patients with ischaemia of the posterior circulation . | NA | {
"id": "C0021308",
"name": "infarcts",
"pos": [
80,
88
]
} | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
318,
327
]
} |
fibronectins are synthesized by a wide variety of cells in vitro including fibroblasts , schwann cells , chondrocytes , myoblasts , macrophages , hepatocytes and intestinal epithelial cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
75,
86
]
} |
fibronectins are synthesized by a wide variety of cells in vitro including fibroblasts , schwann cells , chondrocytes , myoblasts , macrophages , hepatocytes and intestinal epithelial cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
105,
117
]
} |
glucose analogues and others hexoses had some inhibitory effects on glucose uptake , but not polyols and lactose . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
0,
7
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
29,
36
]
} |
the findings in these patients and in 14 previously published cases indicate that neurological manifestations are an integral part of the disorder and suggest that specific structures in the basal ganglia , brainstem , and spinal cord bear the brunt of the pathological process , which does not affect the cerebral cortex . | NA | {
"id": "C0012634",
"name": "disorder",
"pos": [
138,
146
]
} | {
"id": "C0030660",
"name": "pathological process",
"pos": [
257,
277
]
} |
it is also disturbing that in no animal model of infection has beta-lactam monotherapy been superior to aminoglycoside monotherapy or the combination of an aminoglycoside with an antipseudomonal penicillin . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
63,
74
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
195,
205
]
} |
in the respiratory tract milieu of subjects with cf , the interaction of immune and nonimmune opsonins is much more complex because of proteolytic enzymes that can degrade antibodies creating various fragments . | NA | {
"id": "C0029122",
"name": "opsonins",
"pos": [
94,
102
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
172,
182
]
} |
the rate of 14co2 production was decreased to 70 to 80 % of control levels by nmtt and the nmtt-containing beta-lactam antibiotics moxalactam , cefamandole , and cefoperazone . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
144,
155
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
162,
174
]
} |
cefotaxime , cephalothin , and cefuroxime which do not contain the nmtt side chain had no significant effect on 14co2 production . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
0,
10
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
31,
41
]
} |
when compared with astromicin , amikacin , gentamicin , and sisomicin , dactimicin was similar to astromicin in in vitro activity and was more active than amikacin and gentamicin against the clinical isolates of serratia marcescens , but less active against pseudomonas aeruginosa . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
60,
69
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
168,
178
]
} |
dactimicin and astromicin were active against many gentamicin- and amikacin-resistant bacteria expressing aminoglycoside-modifying enzymes , with the exception of aminoglycoside 3-acetyltransferase . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
51,
61
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
163,
177
]
} |
although dna synthesis in growing human embryonic lung fibroblast ( hel ) cells , as determined by [ 3h ] thymidine incorporation , was diminished to 61 % of that in untreated control cells when 22.5 micrograms of acv and 1 microgram of ara-a per ml were used , there was no additive inhibition of dna synthesis when the two-drug combination was used . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
55,
65
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
184,
189
]
} |
the enzyme more rapidly hydrolyzed penicillins , such as penicillin g , ampicillin , carbenicillin , piperacillin , and cloxacillin , than it hydrolyzed cephalosporins . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
57,
69
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
72,
82
]
} |
the enzyme more rapidly hydrolyzed penicillins , such as penicillin g , ampicillin , carbenicillin , piperacillin , and cloxacillin , than it hydrolyzed cephalosporins . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
57,
69
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
85,
98
]
} |
the enzyme more rapidly hydrolyzed penicillins , such as penicillin g , ampicillin , carbenicillin , piperacillin , and cloxacillin , than it hydrolyzed cephalosporins . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
72,
82
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
101,
113
]
} |
the antistaphylococcal activity of rifapentine , a new rifamycin sv derivative , was evaluated in vitro and compared with that of rifampin . | NA | {
"id": "C0035609",
"name": "rifamycin sv",
"pos": [
55,
67
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
130,
138
]
} |
with polidocanol , it was possible to reduce the mic as well as the mbc of methicillin , oxacillin , penicillin g , and ampicillin against resistant staphylococci . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
101,
113
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
120,
130
]
} |
its action can not be simply explained by an improved accessibility of the penicillin targets as uptake , and binding of methicillin and penicillin g in resistant cells was not changed by polidocanol . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
75,
85
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
121,
132
]
} |
the level of activity of cefbuperazone was higher against b. fragilis and lower against anaerobic cocci than those of related cephalosporins , i.e. , cefoxitin , cefoperazone , cefotaxime , ceftizoxime , and cefmenoxime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
177,
187
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
190,
201
]
} |
the level of activity of cefbuperazone was higher against b. fragilis and lower against anaerobic cocci than those of related cephalosporins , i.e. , cefoxitin , cefoperazone , cefotaxime , ceftizoxime , and cefmenoxime . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
177,
187
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
208,
219
]
} |
kss for starch , amylose , and amylopectin were 8.4 , 25.6 , and 11.0 micrograms of c per liter , respectively . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
8,
14
]
} | {
"id": "C0002732",
"name": "amylose",
"pos": [
17,
24
]
} |
kss for starch , amylose , and amylopectin were 8.4 , 25.6 , and 11.0 micrograms of c per liter , respectively . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
8,
14
]
} | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
31,
42
]
} |
at ph 9.0 , apparent michaelis constants were 0.8 , 1.3 , and 2.3 microm for estradiol-17 beta , testosterone , and 20 alpha-dihydroprogesterone , respectively , 17 beta-hsd activity with testosterone was inhibited by estradiol-17 beta , 5 alpha-dihydrotestosterone , 5 beta-dihydrotestosterone , 20 alpha-dihydroprogesterone , and progesterone . | NA | {
"id": "C0012311",
"name": "20",
"pos": [
116,
118
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
332,
344
]
} |
further investigation of this novel activity has demonstrated that it cleaves prohaptoglobin accurately , in the same site-specific manner as the intracellular protease , and that it most likely is not a serine protease or a metalloenzyme but can be inhibited by sulfhydryl-reactive compounds . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
160,
168
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
204,
219
]
} |
two of the major enzymes present in and released from rat mast cells are chymotrypsin-type serine protease ( chymase ) and trypsin-type serine protease ( tryptase ) , and these have been postulated to be important in the inflammatory reactions . | NA | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
73,
85
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
136,
151
]
} |
two of the major enzymes present in and released from rat mast cells are chymotrypsin-type serine protease ( chymase ) and trypsin-type serine protease ( tryptase ) , and these have been postulated to be important in the inflammatory reactions . | NA | {
"id": "C0055673",
"name": "chymase",
"pos": [
109,
116
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
136,
151
]
} |
two of the major enzymes present in and released from rat mast cells are chymotrypsin-type serine protease ( chymase ) and trypsin-type serine protease ( tryptase ) , and these have been postulated to be important in the inflammatory reactions . | NA | {
"id": "C0041236",
"name": "trypsin",
"pos": [
78,
85
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
136,
151
]
} |
two of the major enzymes present in and released from rat mast cells are chymotrypsin-type serine protease ( chymase ) and trypsin-type serine protease ( tryptase ) , and these have been postulated to be important in the inflammatory reactions . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
91,
106
]
} | {
"id": "C0147080",
"name": "tryptase",
"pos": [
154,
162
]
} |
since the plastid genome is a circular double-stranded dna , this is consistent with the proven involvement of a dna gyrase in the replication of closed circular duplex dna genomes in procaryotic cells . | NA | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
39,
54
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
153,
161
]
} |
the translational inhibition produced by addition of oxidized glutathione ( gssg ) to hemin-containing reticulocyte lysates and the accompanying phosphorylation of the alpha subunit of the polypeptide chain initiation factor eif-2 can be prevented or reversed by nadph generators , including glucose 6-phosphate , deoxyglucose 6-phosphate , fructose 6-phosphate , nadph itself , and also by dithiols , e.g. , dithiothreitol , but not by reduced glutathione ( gsh ) or other monothiols , e.g. , 2-mercaptoethanol . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
76,
80
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
459,
462
]
} |
abnormal laboratory findings included leukopenia , granulocytopenia , lymphocytopenia , thrombocytopenia and increased got/gpt/ldh , but these returned to normal by the 10th day after administration . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
38,
48
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
51,
67
]
} |
5-fu , ft and uracil levels in the tumor site were then measured in the surgical specimens obtained . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
0,
4
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
14,
20
]
} |
we reported previously that schizophyllan ( spg ) combined with mmc + 5-fu ( mf regimen ) or tegafur ( f regimen ) had a significant life-prolonging effect over chemotherapeutic regimens in patients with inoperable and recurrent gastric cancer in a randomized controlled study . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
72,
74
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
93,
100
]
} |
in all five patients studied , monoclonal antibody studies of cryostat sections of skin biopsy specimens of anetoderma lesions revealed inflammatory cells reacting with anti-leu-1 , pan-t-cell antibody , and anti-leu-3a , the helper/inducer t-cell antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
31,
50
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
248,
256
]
} |
prostacyclin ( prostaglandin i2 , epoprostenol sodium ) arrested the progress of gangrene in the feet of a 6 year old boy with familial but otherwise unexplained peripheral vascular disease . | NA | {
"id": "C0033567",
"name": "prostaglandin i2",
"pos": [
15,
31
]
} | {
"id": "C0354594",
"name": "epoprostenol sodium",
"pos": [
34,
53
]
} |
we describe a differential extraction system that separates the keratinocyte proteins into four major groups which are further quantitatively analyzed by page : cytoplasmic-soluble proteins , nonionic-detergent-soluble proteins consisting of membrane-associated proteins , salt-dissociated proteins mainly consisting of histones , and ribosomal and keratohyaline granule proteins , and the keratins ( and other intermediate-filament-associated proteins ) , which are further separated into disulfide-stabilized keratins and keratins that do not require reducing agents in order to dissolve in sodium dodecyl sulfate ( sds ) or urea . | NA | {
"id": "C0025252",
"name": "membrane-associated proteins",
"pos": [
242,
270
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
444,
452
]
} |
we describe a differential extraction system that separates the keratinocyte proteins into four major groups which are further quantitatively analyzed by page : cytoplasmic-soluble proteins , nonionic-detergent-soluble proteins consisting of membrane-associated proteins , salt-dissociated proteins mainly consisting of histones , and ribosomal and keratohyaline granule proteins , and the keratins ( and other intermediate-filament-associated proteins ) , which are further separated into disulfide-stabilized keratins and keratins that do not require reducing agents in order to dissolve in sodium dodecyl sulfate ( sds ) or urea . | NA | {
"id": "C0021769",
"name": "intermediate-filament",
"pos": [
411,
432
]
} | {
"id": "C0010803",
"name": "keratins",
"pos": [
524,
532
]
} |
some protein peaks were provisionally identified as actin , the core histones h2a , h2b , h3 , and h4 , ribosomal proteins , and six keratins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
104,
122
]
} |
both enzyme activities were markedly reduced in skin lesions of the arthus reaction ( p less than 0.005 ) , while those in dinitrochlorobenzene allergic dermatitis , croton-oil dermatitis , and the intact areas in arthus-reaction-induced animals were almost within the normal limits . | NA | {
"id": "C0011615",
"name": "allergic dermatitis",
"pos": [
144,
163
]
} | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
177,
187
]
} |
we suggest that the immunopathogenic significance of rfs may not be restricted to their reactivity with igg , and that non-histone nuclear proteins merit further investigation . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
123,
130
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
131,
147
]
} |
between the fourth and 10th passage of the cells in culture apparently no consistent differences were found which could be ascribed to the origin of the cells , to the rheumatoid state of the synovial tissue , or to the increasing age of the cultured fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
251,
262
]
} |
akinesis was detected in 2 segments ( 0.18 % ) , dyskinesis in 45 segments ( 4.26 % ) , hypokinesis in 170 ( 16.09 % ) , hyperkinesis 15 ( 1.42 % ) and normal 824 ( 78.03 % ) . | NA | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
49,
59
]
} | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
88,
99
]
} |
this action of gaba was mimicked by a selective gabab agonist , such as baclofen ( 100 microm ) , but not by selective gabaa agonists as muscimol ( 100 microm ) and homotaurine ( 100 microm ) . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
15,
19
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
72,
80
]
} |
( - ) -lofexidine showed an approximately 9-fold higher affinity than ( + ) -lofexidine for the alpha 2-adrenoceptor-like binding sites in rat brain membranes identified by [ 3h ] -clonidine and was 4 times more potent at displacing [ 3h ] -prazosin from alpha 1-adrenoceptors . | NA | {
"id": "C0065152",
"name": "alpha",
"pos": [
96,
101
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
181,
190
]
} |
l-phenylisopropyl adenosine , l-pia ) and antagonists ( theophylline ; 3-isobutyl-1-methylxanthine , ibmx ) but unaffected by an adenosine uptake inhibitor ( papaverine ) . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
56,
68
]
} | {
"id": "C0000096",
"name": "ibmx",
"pos": [
101,
105
]
} |
apomorphine , a dopamine receptor agonist , physostigmine , an anticholinesterase agent and pilocarpine , a cholinergic receptor agonist , produced yawning in rats , with the most effective doses being 0.25 mg/kg , 0.2 mg/kg and 4 mg/kg , respectively . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
92,
103
]
} | {
"id": "C3536927",
"name": "cholinergic receptor agonist",
"pos": [
108,
136
]
} |
a significant antagonism of a steady state depression of the twitch height induced by vecuronium was observed during approximately 10 min after i.v . injection of those benzodiazepines containing organic solvents in their formulations ( diazepam , desmethyldiazepam , oxazepam , temazepam , lorazepam and lormetazepam ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
237,
245
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
248,
265
]
} |
after the initial antagonism , a potentiation of the vecuronium-induced depression occurred with some of these benzodiazepines ( diazepam , desmethyldiazepam , temazepam and lormetazepam ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
129,
137
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
140,
157
]
} |
the effect of hemodialysis on plasma norepinephrine ( ne ) , epinephrine , and dopamine levels was studied in 11 patients undergoing maintenance hemodialysis . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} |
intradialysis weight loss and fall in the serum glucose concentration during dialysis correlated with changes in plasma epinephrine and ne concentrations . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
136,
138
]
} |
review of the literature is included to highlight the fulminant nature of this unusual infection and to contrast streptococcal myositis with other soft-tissue streptococcal infections . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
87,
96
]
} | {
"id": "C0149778",
"name": "soft-tissue",
"pos": [
147,
158
]
} |
100 of cases , c ) failure ( 31.4 p. 100 ) due to non-capture or intolerance ( 20.6 p. 100 ) or recurrence of the arrhythmia after transient atrial fibrillation ( 10.8 p. 100 ) . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
114,
124
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
141,
160
]
} |
in 33 cases ( 23 fallot 's tetralogy the object was to detect coronary abnormalities not observed on non-selective opacification ( 3 lad arteries arising from the right coronary , 1 single coronary artery ) or to determine their anatomical relationships in complex cardiac malformations ( 5 cases ) . | NA | {
"id": "C0039685",
"name": "fallot 's",
"pos": [
17,
26
]
} | {
"id": "C0018798",
"name": "coronary abnormalities",
"pos": [
62,
84
]
} |
the most common atrial arrhythmia was atrial fibrillation ( af ) which was observed in 27 p . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
23,
33
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
38,
57
]
} |
it was not possible to reinitiate vt after treatment in 3 out of 6 cases ( very aggressive pacing methods , a long qt interval and accelerated idio-ventricular rhythm were responsible for the failures ) . | NA | {
"id": "C0042514",
"name": "vt",
"pos": [
34,
36
]
} | {
"id": "C0078888",
"name": "accelerated",
"pos": [
131,
142
]
} |
[ electrocardiographic studies of the modification of cardiac activity in cattle by adrenaline and noradrenaline with and without vagolysis ( atropine ) and beta-receptor blockade ( propranolol ) ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
84,
94
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
99,
112
]
} |
[ factors of meningeal diffusion of amoxicillin and ampicillin at the acute phase of purulent meningitis in children ] . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
36,
47
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
52,
62
]
} |
rbf absorption was studied following oral administration of 150mg rbf as 5'-phosphate flavin mononucleotide in ten clinically complete quadriplegic patients ( c1 to c7 , two to 15 months post-onset ) and six control subjects matched for age , sex , and weight . | NA | {
"id": "C0035527",
"name": "rbf",
"pos": [
0,
3
]
} | {
"id": "C0016388",
"name": "flavin mononucleotide",
"pos": [
86,
107
]
} |
the content of free basic amino acids in the blood plasma decreased with the decreasing supply with amino acids and energy , whereas the content of free amino acids with branched chains and hydroxylized ones increased . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
20,
37
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
153,
164
]
} |
the protective action of the 2nd type neuroleptanalgesia ( nla ) preparations on the damaged myocardium in experimental infarction complicated by cardiogenic shock is documented and analysed . | NA | {
"id": "C0027051",
"name": "myocardium",
"pos": [
93,
103
]
} | {
"id": "C0036980",
"name": "cardiogenic",
"pos": [
146,
157
]
} |
the use of nla within the first 5 days of the infarction complicated by cardiogenic shock decreased the intensity of the myocardial damage in the zone around the infarction and prevented necrotic changes in teh `` '' extra-infarction '' '' myocardium . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
72,
89
]
} | {
"id": "C0027051",
"name": "necrotic",
"pos": [
187,
195
]
} |
after he had failed to respond clinically to a two months course of high-dose oral prednisolone , a regimen of intravenous methyl prednisolone 1 g once a week for eight weeks was instituted , along with 10 mg prednisolone orally daily . | NA | {
"id": "C0025815",
"name": "methyl prednisolone",
"pos": [
123,
142
]
} | {
"id": "C0032950",
"name": "orally",
"pos": [
222,
228
]
} |
this method is proposed for the assessment of contractility under conditions of heart rate variations ( physiological and pathological arrhythmias ) . | NA | {
"id": "C0018799",
"name": "conditions of heart",
"pos": [
66,
85
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
135,
146
]
} |
by using both the isolated iron-protein fraction and the intact dehydrogenase , cross-links were identified between these four subunits , from these subunits to the largest subunit of the flavoprotein fraction , which contains the active site for nadh , and from these subunits to polypeptides in the hydrophobic shell , which surrounds the hydrophilic iron-protein and flavoprotein fractions . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
32,
39
]
} | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
370,
382
]
} |
the main polysaccharides in these complexes were ( acidic ) arabinoxylans , galactans , arabinogalactans 1 and 2 and xyloglucans . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
9,
24
]
} | {
"id": "C0016932",
"name": "galactans",
"pos": [
95,
104
]
} |
although the cultured fibroblasts were similar to control skin fibroblasts in morphology , growth rate and total protein synthesis , there was a 4-6-fold increase in accumulation of a collagenous protein of mr 140 000 in both the culture medium and in the cell layer . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
22,
33
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
256,
260
]
} |
the reaction mechanism of the human erythrocyte 5-aminolaevulinate dehydratase thus follows the same course as that of other dehydratases studied in our laboratory by using single-turnover techniques . | NA | {
"id": "C0002564",
"name": "aminolaevulinate dehydratase",
"pos": [
50,
78
]
} | {
"id": "C0020239",
"name": "dehydratases",
"pos": [
125,
137
]
} |
microsomal fractions obtained from testes of 3-week-old piglets have been incubated , separately , with progesterone , 17-hydroxyprogesterone , 5-pregnene-3 beta,20 beta-diol , 16 alpha-hydroxypregnenolone , 5-androstene-3 beta,17 alpha-diol and dehydro-epiandrosterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
104,
116
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
119,
141
]
} |
for the intermediate filament protein vimentin , basal phosphorylation was largely at a site distinct from that stimulated by increased cyclic amp , and basal phosphorylation was not markedly different in mutant and wild-type cells . | NA | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
8,
37
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
38,
46
]
} |
this content could be related to glucose utilization during the same time period , since ( 1 ) the integral of the decrease of 2-deoxy [ 3h ] glucose in arterial blood was known and ( 2 ) correction factors for the analogue effect of 2-deoxyglucose compared with glucose in the transport and phosphorylation steps were determined from experiments in vitro . | NA | {
"id": "C0005802",
"name": "glucose in",
"pos": [
142,
152
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
263,
270
]
} |
multiple proteins related to the soluble galactose-binding animal lectin revealed by a monoclonal anti-lectin antibody . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
9,
17
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
103,
109
]
} |
multiple proteins related to the soluble galactose-binding animal lectin revealed by a monoclonal anti-lectin antibody . | NA | {
"id": "C0607430",
"name": "galactose-binding",
"pos": [
41,
58
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
103,
109
]
} |
immunoblotting experiments revealed an array of antigenically active components in the homogenates in addition to the 13 and 26kda proteins that were previously detected in preparations of purified lectin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
131,
139
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
198,
204
]
} |
t3- specific antibodies have the thyroxine residue as a peripheral feature of the binding site , and it is not necessary to postulate that t3 was part of the immunogen or is required in the epitope . | NA | {
"id": "C0003320",
"name": "immunogen",
"pos": [
158,
167
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
190,
197
]
} |
the dna-binding surface was mapped by identification of nh2 groups protected from modification when the protein is bound to bacteriophage-pf1 dna in the native nucleoprotein complex and when bound to the synthetic oligonucleotide d ( gcgttgcg ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
104,
111
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
160,
173
]
} |
the differences observed in protection from acetimidation , and in the ability of the modified protein to bind dna , indicate that the oligonucleotide mode of binding is not identical with that found in the native nucleoprotein complex with bacteriophage-pf1 dna . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
95,
102
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
214,
227
]
} |
the initial rates of transfer of [ 3h ] cholesterol from ldl and high-density lipoprotein ( hdl ) were of the same order of magnitude ( 0.67 +/- 0.05 and 0.75 +/- 0.06 nmol of cholesterol/h per mg of cell protein , respectively ) while that from very-low-density lipoprotein ( vldl ) was much lower ( 0.23 +/- 0.02 nmol of cholesterol/h per mg ) ( means +/- s.d. , n = 5 ) . | NA | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
40,
51
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
323,
334
]
} |
if albumin was added to the incubation medium the transfer of [ 3h ] cholesterol was enhanced , while that of [ 14c ] dipalmitoyl phosphatidylcholine was decreased compared with the protein-free system . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
3,
10
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
182,
189
]
} |
ouchterlony double diffusion analysis and antibody inhibition of alkaline phosphatase by antisera against the mucosa enzyme demonstrate that the two forms of intestinal enzyme have apparently identical antigenicity . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
42,
50
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
89,
97
]
} |
the secretolytic agent bromhexine and its active metabolite ambroxol prevent the collagen- and adp-induced decrease in circulating blood platelets in rabbits , while they do not inhibit the aggregation induced by adp , collagen or arachidonic acid of human and rabbit blood platelets in vitro . | NA | {
"id": "C0006220",
"name": "bromhexine",
"pos": [
23,
33
]
} | {
"id": "C0002421",
"name": "ambroxol",
"pos": [
60,
68
]
} |
in addition to somatostatin-14 , both free arginine and free lysine were identified together with somatostatin-28 . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
15,
30
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
98,
113
]
} |
since it is likely that the octacosapeptide is a precursor for both somatostatin-14 and somatostatin-28 , these observations add further support to the hypothesis that the convertase is also involved in the in vivo processing of endogenous somatostatin-28 . | NA | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
68,
83
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
240,
255
]
} |
the somatomedin-binding protein isolated from a human hepatoma cell line is identical to the human amniotic fluid somatomedin-binding protein . | NA | {
"id": "C0074825",
"name": "somatomedin-binding protein",
"pos": [
4,
31
]
} | {
"id": "C0123256",
"name": "amniotic fluid",
"pos": [
99,
113
]
} |
after incubation with 250 microm mg2+ for 10 minutes , actin binds cytochalasin d with a kd of 2.6 microm but with one mole of cytochalasin d per 2 moles of actin . | NA | {
"id": "C0010738",
"name": "cytochalasin d",
"pos": [
67,
81
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
127,
139
]
} |
the calf eye lens homogenate incubated with [ 1-14c-acetyl ] aspirin and separated into hmw , alpha , beta h , beta l and gamma-crystallins by means of sepharose 6b and bio-gel p2 columns showed radioactivity in all the crystallins . | NA | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
122,
139
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
220,
231
]
} |
the significant decrease in the free epsilon-amino groups of aspirin-treated crystallins further suggests the probable sites of acetylation in the crystallins . | NA | {
"id": "C0014641",
"name": "epsilon",
"pos": [
37,
44
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
147,
158
]
} |
it may be concluded that acetylation of free epsilon-amino groups of lens crystallins by aspirin may confer protection against crystallin aggregation in cataractogenesis . | NA | {
"id": "C0014641",
"name": "epsilon",
"pos": [
45,
52
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
127,
137
]
} |
the phorbol ester 4 beta-phorbol-12-myristate-13-acetate stimulated steroidogenesis and the phosphorylation of a 17 kd and a 33 kd protein , which was also stimulated by lh , whereas the inactive phorbol ester 4 beta-phorbol-12,13-diacetate did not have any effects . | NA | {
"id": "C0039654",
"name": "phorbol",
"pos": [
4,
11
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
196,
209
]
} |
there was no correlation , however , between the mean intensity of fluorescence and intracellular levels of lipids belonging to different classes : phospholipids , triglycerides , cholesterol or cholesteryl esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
180,
191
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
195,
206
]
} |
non-deuterated oligopeptides containing phe in position 3 and no methyl groups induced different changes in neurophysin methyl resonances than dipeptides , suggesting shielding of one or more protein methyl groups by phe-3 . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
15,
28
]
} | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
143,
153
]
} |
these results suggest that this enzyme is a different type of serine protease from trypsin and thrombin . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
62,
77
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
83,
90
]
} |
we evaluated whether the donor amine may be obtained from branched chain amino acid uptake by perfusing muscle in situ with 1.0 mm [ 15n ] -leucine during a 1 hr recovery . | NA | {
"id": "C0002521",
"name": "branched",
"pos": [
58,
66
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
140,
147
]
} |
bay k 8644 and nitrendipine , dihydropyridines classified as calcium channel agonist and antagonist , respectively , produced concentration-dependent biphasic responses ( contraction and relaxation ) in porcine coronary artery rings . | NA | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
15,
27
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
30,
46
]
} |
the phorbol ester , 12-o-tetradecanoylphorbol-13-acetate enhances the long-term maintenance of pancreatic islet b cell differentiated function in tissue culture . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
20,
56
]
} |
a study was undertaken to examine the effects of the tumor-promoting phorbol ester , 12-o-tetradecanoylphorbol-13-acetate , on pancreatic islet b cell differentiated function and number . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
69,
76
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
85,
121
]
} |
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