text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
ceftizoxime and cefotaxime were more active than cefuroxime and cefoperazone against enterobacter spp. , and proteus morganii . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
16,
26
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
49,
59
]
} |
they are , however , most probably due to the specific properties of the interactions between lipids and proteins that differ among the lipoproteins . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
94,
100
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
136,
148
]
} |
the pl surveyed were phosphatidic acid ( pa ) , phosphatidylglycerol ( pg ) , phosphatidylethanolamine ( pe ) , phosphatidylcholine ( pc ) and phosphatidylinositol ( pi ) . | NA | {
"id": "C0162448",
"name": "pl",
"pos": [
4,
6
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
78,
102
]
} |
the pl surveyed were phosphatidic acid ( pa ) , phosphatidylglycerol ( pg ) , phosphatidylethanolamine ( pe ) , phosphatidylcholine ( pc ) and phosphatidylinositol ( pi ) . | NA | {
"id": "C0162448",
"name": "pl",
"pos": [
4,
6
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
112,
131
]
} |
the pl surveyed were phosphatidic acid ( pa ) , phosphatidylglycerol ( pg ) , phosphatidylethanolamine ( pe ) , phosphatidylcholine ( pc ) and phosphatidylinositol ( pi ) . | NA | {
"id": "C0162448",
"name": "pl",
"pos": [
4,
6
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
143,
163
]
} |
the temperature dependence of the force/area isotherms of monolayer of distearoyl phosphatidylcholine ( dspc ) , diisoeicosanoyl phosphatidylcholine ( diepc ) and a complete mixed compositional range of these two lecithins are reported . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
82,
101
]
} | {
"id": "C0031617",
"name": "lecithins",
"pos": [
213,
222
]
} |
the isotherms of diepc , an iso-branched lecithin , show differences from these obtained for similar straight-chain lecithins in that the full condensed isotherms are more expanded , the fully expanded isotherms are more condensed and therefore the liquid expanded ( le ) /liquid condensed ( lc ) intermediate region is significantly reduced . | NA | {
"id": "C1959616",
"name": "diepc",
"pos": [
17,
22
]
} | {
"id": "C0031617",
"name": "lecithins",
"pos": [
116,
125
]
} |
calcium channel blockers also potentiate the antitumor activities of several dna-interacting drugs , such as adriamycin , thp-adriamycin , daunomycin , aclacinomycin a , mitomycin c , actinomycin d , mitoxantrone , and nogalamycin derivatives in p388 leukemia resistant to adriamycin . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
139,
149
]
} | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
219,
230
]
} |
in dual-label experiments , where the epidermal dna was pre-labeled with [ 14c ] thymidine , [ 3h ] b [ a ] p dna-adduct disappearance between 24-48 h was clearly more rapid than could be explained on the basis of epidermal dna turnover . | NA | {
"id": "C0242958",
"name": "dna-adduct",
"pos": [
110,
120
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
224,
227
]
} |
co-administration of ndma and nmbza produced no more foci than ndma alone , even though the combined effect of the two nitrosamines on dna methylation was additive . | NA | {
"id": "C0012431",
"name": "ndma",
"pos": [
21,
25
]
} | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
119,
131
]
} |
a keratinocyte cell-mediated mutation assay was used to examine the importance of cellular proximity to the transfer of mutagenic and cytotoxic polycyclic aromatic hydrocarbon ( pah ) metabolites between cells . | NA | {
"id": "C0022567",
"name": "cell",
"pos": [
15,
19
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
82,
90
]
} |
when these nitrosamines ( 25 micromole/kg ) were administered orally to rats , the clearance of ndma from the serum and liver was faster than that of nmbea . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
11,
23
]
} | {
"id": "C0012431",
"name": "ndma",
"pos": [
96,
100
]
} |
the ratio of ndma demethylation to nmbea demethylation and debenzylation by hepatic microsomes also changed depending on nitrosamine concentrations ( 1 microm to 1 mm ) , and low concentration of ndma was demethylated rapidly . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
121,
132
]
} | {
"id": "C0012431",
"name": "ndma",
"pos": [
196,
200
]
} |
the nad content of 46br cells is similar to that of fibroblasts from normal human donors , as is the decrease in nad content following treatment with dimethylsulphate . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
52,
63
]
} |
since it is known that inhibition of sulfation of n-hydroxy-2-acetylaminofluorene prevents the formation of covalently-bound 2-acetylaminofluorene adducts to proteins , rna , and dna in the rat liver ( meerman et al. , carcinogenesis , 2 , 413-416 , 1981 ) , the results from this study suggest that deacetylated , 2-aminofluorene adducts to dna are responsible for initiation of gamma-glutamyltranspeptidase positive foci in the rat liver ( because formation of these adducts is not affected by pentachlorophenol ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
179,
182
]
} | {
"id": "C0242958",
"name": "adducts",
"pos": [
469,
476
]
} |
after 1 and 2 weeks feeding , peroxidation was no longer evident in lipids isolated from mitochondria , while the microsomal membrane lipids showed persistent conjugated dienes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
68,
74
]
} | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
125,
140
]
} |
n- ( 2-mercaptoethyl ) -1,3-diaminopropane ( wr1065 ) protects against radiation-induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase ( hgprt ) locus in v79 chinese hamster lung fibroblast cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
89,
93
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
217,
227
]
} |
the dna isolated from the livers was analyzed for possible carcinogen-dna adducts , by a most sensitive 32p-postlabeling technique which can detect one adduct in 10 ( 10 ) nucleotides . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
4,
7
]
} | {
"id": "C0242958",
"name": "carcinogen-dna",
"pos": [
59,
73
]
} |
kinins released by vascular kininogenase were identified as bradykinin by reverse-phase high performance liquid chromatography . | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
0,
6
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
60,
70
]
} |
norepinephrine and epinephrine were equipotent stimulants of hypertrophy and beating , increasing cell protein and area 1.5- to 2-fold , and the proportion of beating cells from 5 % or less to 95 % . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
19,
30
]
} |
studies with other agonists ( phenylephrine , methoxamine , clonidine , isoproterenol , dopamine ) and antagonists ( prazosin , terazosin , yohimbine , propranolol , betaxolol , ici 118,551 ) indicated that hypertrophy was mediated through an alpha 1-adrenergic receptor , whereas the induction of beating required both alpha 1- and beta 1-receptor activation . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
117,
125
]
} | {
"id": "C0076107",
"name": "terazosin",
"pos": [
128,
137
]
} |
to provide insight into charge effects on transendothelial passage , the permeability values of small inorganic cations ( labeled sodium and rubidium , and stable potassium ) and anions ( labeled chloride , iodide , sulfate , and ferrocyanide ) were compared to those expected for neutral solutes with approximately matched diffusion coefficients , and that of a neutral dextran fraction was compared to that of a negatively charged dextran sulfate with a similar diffusion coefficient . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
179,
185
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
196,
204
]
} |
to provide insight into charge effects on transendothelial passage , the permeability values of small inorganic cations ( labeled sodium and rubidium , and stable potassium ) and anions ( labeled chloride , iodide , sulfate , and ferrocyanide ) were compared to those expected for neutral solutes with approximately matched diffusion coefficients , and that of a neutral dextran fraction was compared to that of a negatively charged dextran sulfate with a similar diffusion coefficient . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
179,
185
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
207,
213
]
} |
to provide insight into charge effects on transendothelial passage , the permeability values of small inorganic cations ( labeled sodium and rubidium , and stable potassium ) and anions ( labeled chloride , iodide , sulfate , and ferrocyanide ) were compared to those expected for neutral solutes with approximately matched diffusion coefficients , and that of a neutral dextran fraction was compared to that of a negatively charged dextran sulfate with a similar diffusion coefficient . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
179,
185
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
441,
448
]
} |
we evaluated the efficacy of a single oral dose of procainamide to terminate paroxysmal tachycardia , when procainamide was taken shortly after onset of tachycardia , a regimen we have termed `` '' periodic procainamide . '' '' | NA | {
"id": "C0039236",
"name": "paroxysmal tachycardia",
"pos": [
77,
99
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
153,
164
]
} |
in 12 patients ( mean age 15 years ) with non-life-threatening tachycardia ( orthodromic reciprocating tachycardia , 8/12 ; ventricular tachycardia , 3/12 ; atrial flutter , 1/12 ) in whom intravenously administered procainamide ( 15 mg/kg at 1 mg/kg/min ) terminated tachycardia , efficacy of a single oral dose of procainamide ( 25 mg/kg ) to terminate tachycardia was tested during electrophysiologic study . | NA | {
"id": "C0242514",
"name": "reciprocating tachycardia",
"pos": [
89,
114
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
355,
366
]
} |
in 12 patients ( mean age 15 years ) with non-life-threatening tachycardia ( orthodromic reciprocating tachycardia , 8/12 ; ventricular tachycardia , 3/12 ; atrial flutter , 1/12 ) in whom intravenously administered procainamide ( 15 mg/kg at 1 mg/kg/min ) terminated tachycardia , efficacy of a single oral dose of procainamide ( 25 mg/kg ) to terminate tachycardia was tested during electrophysiologic study . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
124,
147
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
355,
366
]
} |
it is uncertain if this potentially important feature renders t-pa less hemorrhagic than other plasminogen activators . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
62,
66
]
} | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
95,
117
]
} |
fibrinopeptide a ( fpa ) concentrations in plasma and in 24 hr urine specimens as well as beta-thromboglobulin ( btg ) in plasma were measured in 17 patients with severe angina pectoris , including both stable and unstable angina , and in 19 patients with acute myocardial infarction . | NA | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
170,
185
]
} | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
214,
229
]
} |
the specific symptoms induced by eating celery were attacks of urticaria and angio oedema ( seventeen out of twenty ) respiratory complaints ( eight out of twenty ) , systemic anaphylaxis with vascular collapse ( three out of twenty ) . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
63,
72
]
} | {
"id": "C0002994",
"name": "angio oedema",
"pos": [
77,
89
]
} |
we examined the variability of lipid and lipoprotein concentrations in plasma from a population sample from the jerusalem lipid research clinic study . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
31,
36
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
41,
52
]
} |
within-assay analytical variation ( cv ) was 1.9-2.0 % for cholesterol , 1.5-2.3 % for triglyceride , and 4.5 % for high-density-lipoprotein cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
59,
70
]
} | {
"id": "C0023822",
"name": "high-density-lipoprotein cholesterol",
"pos": [
116,
152
]
} |
these three iggs formed soluble complexes with four ( ld 1 , 2 , 3 , 5 ) of the five ld isoenzymes in two of the patients and in the third they bound with three ( ld 2 , 3 , 4 ) of the five ld isoenzymes without inhibiting the enzyme activity or precipitating with the enzyme molecules . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
88,
98
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
269,
275
]
} |
we describe a method for determining the `` '' total '' '' excretion of acidic metabolites of catecholamines by measuring 3,4-dihydroxyphenylacetic acid ( dopac ) formed by hydriodic acid hydrolysis of 4-hydroxy-3-methoxyphenylacetic acid ( hva ) , 4-hydroxy-3-methoxymandelic acid ( vma ) , and their conjugates . | NA | {
"id": "C0001128",
"name": "f acid",
"pos": [
70,
76
]
} | {
"id": "C0063090",
"name": "hydriodic ac",
"pos": [
173,
185
]
} |
preliminary results for patients with neuroblastoma and melanoma indicate the potential usefulness of the method for diagnosis and prognosis of patients with neural crest tumors that produce dopa or catecholamines . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
191,
195
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
199,
213
]
} |
the tissue origin of the enzyme bands was readily ascertainable from their consistent electrophoretic location in this medium , and in 89 of the specimens the isoenzyme fractions could be resolved into separate peaks on densitometry . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
25,
31
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
159,
168
]
} |
the method of mean tensor analysis was used to study the cranial base in six craniofacial anomalies : crouzon 's disease , apert 's syndrome , pfeiffer 's syndrome , craniofacial microsomia ( cfm ) , treacher collins ( tc ) syndrome , and frontonasal dysplasia ( fnd ) . | NA | {
"id": "C0376634",
"name": "craniofacial anomalies",
"pos": [
77,
99
]
} | {
"id": "C0010273",
"name": "crouzon 's disease",
"pos": [
102,
120
]
} |
the method of mean tensor analysis was used to study the cranial base in six craniofacial anomalies : crouzon 's disease , apert 's syndrome , pfeiffer 's syndrome , craniofacial microsomia ( cfm ) , treacher collins ( tc ) syndrome , and frontonasal dysplasia ( fnd ) . | NA | {
"id": "C0010273",
"name": "crouzon 's disease",
"pos": [
102,
120
]
} | {
"id": "C0242387",
"name": "treacher collins",
"pos": [
200,
216
]
} |
the activity of galactosylhydroxylysyl glucosyltransferase , an enzyme catalyzing collagen biosynthesis , was measured in the sera of 101 patients with various pulmonary diseases to study whether detectable enzyme amounts are liberated into the serum from the lung tissue , and whether this is associated with the development of lung fibrosis . | NA | {
"id": "C0024115",
"name": "pulmonary diseases",
"pos": [
160,
178
]
} | {
"id": "C0034069",
"name": "of lung fibrosis",
"pos": [
326,
342
]
} |
a rapid and inexpensive method is described for the enrichment of fetal hemoglobin ( hbf ) which eliminates the interference of other hemoglobins in the hplc analysis of gamma chains when hbf is less than or equal to 20-30 % of the total hb . | NA | {
"id": "C0015936",
"name": "hbf",
"pos": [
85,
88
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
238,
240
]
} |
transplantable norepinephrine-rich tumors , which gave rise to significant blood pressure elevations , contained measurable immunoreactive enkephalins as determined by specific radioimmunoassays for leucine-enkephalin and methionine-enkephalin . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
139,
150
]
} | {
"id": "C0014294",
"name": "leucine-enkephalin",
"pos": [
199,
217
]
} |
transplantable norepinephrine-rich tumors , which gave rise to significant blood pressure elevations , contained measurable immunoreactive enkephalins as determined by specific radioimmunoassays for leucine-enkephalin and methionine-enkephalin . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
139,
150
]
} | {
"id": "C0014295",
"name": "methionine-enkephalin",
"pos": [
222,
243
]
} |
in the convalescent phase , 78 % of total anti-influenza a antibodies were estimated to be of igg1 isotype and other immunoglobulin isotypes varied from 3 to 7 % of total . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
59,
69
]
} | {
"id": "C0021017",
"name": "immunoglobulin isotypes",
"pos": [
117,
140
]
} |
the kinetics of total haemolytic activity showed a slower decay with an exponential decline over 72 h and a half-life of 55 h . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
4,
12
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
108,
117
]
} |
cardiac tissue sections from han showed reactivity with antisera to amyloid han , pre-albumin and protein ap , but not with anti-aa or anti-al in indirect immunofluorescence . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
86,
93
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
98,
105
]
} |
it is suggested that the t4 lymphopenia was a reaction to the mycobacterial infection and not a manifestation of underlying secondary ( acquired ) immune deficiency . | NA | {
"id": "C0024312",
"name": "lymphopenia",
"pos": [
28,
39
]
} | {
"id": "C0021051",
"name": "immune deficiency",
"pos": [
147,
164
]
} |
immunopathological correlates were sought in lcl and dcl with immunoperoxidase techniques using monoclonal antibodies directed against t lymphocyte subpopulations and interleukin-2 in tissue lesions . | NA | {
"id": "C0023283",
"name": "lcl",
"pos": [
45,
48
]
} | {
"id": "C0085311",
"name": "dcl",
"pos": [
53,
56
]
} |
both lcl and dcl granulomas showed a mixture of t lymphocyte subpopulations with the ratio of helper : suppressor phenotypes less than one . | NA | {
"id": "C0023283",
"name": "lcl",
"pos": [
5,
8
]
} | {
"id": "C0085311",
"name": "dcl",
"pos": [
13,
16
]
} |
in contrast , interleukin-2 was identified in equivalent numbers of cells in lcl and tuberculoid leprosy , an order of magnitude greater than dcl and lepromatous leprosy lesions . | NA | {
"id": "C0023283",
"name": "lcl",
"pos": [
77,
80
]
} | {
"id": "C0085311",
"name": "dcl",
"pos": [
142,
145
]
} |
these results indicate that a common epitope is widely shared among antigens of m. tuberculosis and other mycobacteria and they suggest that species specificity of mycobacterial antigens may rest with individual epitopes rather than intact antigenic molecules . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
212,
220
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
240,
249
]
} |
the virus stimulates production of ifn by nucleated cells including the peripheral blood mononuclear cells ( pbmc ) , and this ifn in turn activates several ifn-dependent immune mechanisms including the induction of an anti-viral state in cells , which prevents or retards further intracellular viral replication . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
72,
106
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
239,
244
]
} |
a panel of monoclonal antibodies was used to identify t cells and t cell subsets , together with antibody markers of cell stimulation ( the t2 40 kdalton t blast specificity ) , proliferation ( t9 and ki67 ) and activation ( hla-dr and ig receptors ) . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
11,
32
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
97,
105
]
} |
the potency of dopamine as a beta-agonist was 1/10 000 that of isoprenaline , 1/250 that of adrenaline and 1/50 that of noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
92,
102
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
120,
133
]
} |
in order to determine whether vasodilator prostaglandins ( pg ) contribute to the acute vascular and endocrine responses to intravenously administered dihydralazine , we examined its effects on systolic and diastolic blood pressure ( bp ) , heart rate ( hr ) , plasma renin activity ( pra ) and the plasma catecholamines ( ca ) noradrenaline ( na ) , adrenaline ( a ) and dopamine ( da ) as well as on sodium , potassium and creatinine clearance ( cna , ck and ccr respectively ) , urinary flow rate , urinary catecholamines ( na , a , da ) and ipge2 and i6-keto-pgf1 alpha excretion rate in six patients ( three females , three males ) with essential hypertension before and after pg synthesis inhibition by the nonsteroidal , anti-inflammatory agent diclofenac . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
331,
341
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
759,
761
]
} |
diclofenac , which reduced urinary ipge2 and i6-keto-pgf1 alpha excretion by 62 % ( p = 0.026 ) and 45 % ( p = 0.037 ) , respectively , antagonized dihydralazine induced diastolic bp reduction ( p = 0.0009 ) , hr increase ( p = 0.01 ) , noradrenaline and adrenaline increase in plasma ( p = 0.02 and p = 0.05 , respectively ) , increase in urine flow rate ( p = 0.03 ) , sodium clearance ( p = 0.01 ) and tended to reduce pra . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
237,
250
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
255,
265
]
} |
neither a high protein diet ( 50 % fish protein ) nor a low protein diet ( 5 % protein ) changed the salt water preference in shrsr and the former abolished the preference more quickly in shrsp . | NA | {
"id": "C0598294",
"name": "fish protein",
"pos": [
35,
47
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
79,
86
]
} |
we report here that the chemotactic peptide , n-formyl-methionyl-leucyl-phenylalanine ( fmlp ) , and the mitogenic phorbol ester , phorbol myristate acetate ( pma ) cause a time- and concentration-dependent , selective , extracellular release of n-acetyl-beta-glucosaminidase and lysozyme from freshly isolated , adherent human peripheral blood monocytes . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
115,
128
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
131,
156
]
} |
highly purified human t cells were obtained by a four-step purification procedure which included : removal of plastic adherent cells , rosetting with sheep red cells , passage over nylon-wool columns , and treatment with mouse monoclonal antibodies to human ia antigens and complement . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
110,
117
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
181,
186
]
} |
characterizing the isotype , subclass , and fine antigen specificity of antiguanosine antibodies should assist in evaluating their potential pathogenicity in sle . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
19,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
86,
96
]
} |
patients with mitral valve prolapse ( mvp ) frequently have chest pain , which may be difficult to differentiate from angina pectoris in coronary artery disease ( cad ) . | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
60,
70
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
118,
133
]
} |
of the specimens , 53.3 percent were type a , b , or ab , and 19.3 percent of both a and b infants and 7 percent of ab infants had immune antibodies in their sera . | NA | {
"id": "C0020960",
"name": "immune",
"pos": [
131,
137
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
138,
148
]
} |
pediatric drugs may have significant nutritional consequences via their effects on appetite , nutrient absorption , nutrient metabolism , and nutrient excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
125,
135
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
151,
160
]
} |
features suggestive of bartter syndrome ( hypokalemia , hypochloremic metabolic alkalosis , and normal blood pressure despite hyperreninemia and hyperaldosteronism ) were found in a 5-year-old black child with cystinosis and fanconi syndrome . | NA | {
"id": "C0004775",
"name": "bartter syndrome",
"pos": [
23,
39
]
} | {
"id": "C0020428",
"name": "hyperaldosteronism",
"pos": [
145,
163
]
} |
during the infusion there was at least a fifty- to 100-fold increase in uracil and thymine plasma concentrations . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
72,
78
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
83,
90
]
} |
plasma uracil and thymine levels slowly decreased after the idurd infusion until iura fell to less than 30 mumol/l . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
7,
13
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
18,
25
]
} |
there was subsequently a parallel and more rapid decrease in the plasma concentrations of uracil and thymine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
90,
96
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
101,
108
]
} |
we studied the extent to which there are significant temporal changes in theophylline kinetics and the relative contribution of distribution , metabolism , and excretion to this phenomenon . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
143,
153
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
160,
169
]
} |
collagen accumulation in the neonatal rat skin : absence of fibrillar collagen degradation during normal growth . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
0,
8
]
} | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
60,
78
]
} |
furthermore , the inhibition of collagen synthesis in these animals resulted in a constant chemical content of collagen as well as a constant amount of proteinaceous [ 14c ] -hydroxyproline after injection of [ 14c ] -proline over a 72-hour period . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
175,
189
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
218,
225
]
} |
of the three major skin surface lipid components , the sterol esters ( 25 % ) and the wax diesters ( 25 % ) showed similar peaks of radioactivity after labelling , but the glycerol ether diesters ( 30 % ) showed no radioactivity at any time , suggesting that this lipid is not produced in the skin . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
86,
89
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
264,
269
]
} |
rates of oxidation of alanine , threonine and glutamine and flux rates of tyrosine aminotransferase and tryptophan 2,3-dioxygenase were greater in cells from hp fed cats at all amino acid concentrations used . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
22,
29
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
177,
187
]
} |
changes in spike frequency , membrane potential and input resistance of somata freshly isolated from neurons in the metathoracic ganglia of adult locusts ( schistocerca gregaria ) during bath and ionophoretic application of putative amino acid transmitters and analogues were studied using intracellular techniques . gamma-aminobutyrate , glycine , taurine , cysteine and dl-ibotenate hyperpolarized the isolated soma , the response to kainic acid was depolarizing whereas l-glutamate and l-aspartate evoked a variety of potential changes . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
233,
243
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
339,
346
]
} |
such fibres , however , can be rendered responsive by preinjecting into them the non-hydrolysable gtp analogue , gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
98,
101
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
113,
125
]
} |
the molluscan neuropeptide , phe-met-arg-phe-nh2 ( fmrfamide ) , the mammalian opioid peptide met-enkephalin , and their common analogues , met-enkephalin-arg6-phe7 ( yggfmrf ) and tyr-gly-gly-phe-met-arg-phe-amide ( yggfmrfamide ) , were injected into the lateral ventricle of the rat ; | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
14,
26
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
220,
229
]
} |
the molluscan neuropeptide , phe-met-arg-phe-nh2 ( fmrfamide ) , the mammalian opioid peptide met-enkephalin , and their common analogues , met-enkephalin-arg6-phe7 ( yggfmrf ) and tyr-gly-gly-phe-met-arg-phe-amide ( yggfmrfamide ) , were injected into the lateral ventricle of the rat ; | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
14,
26
]
} | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
79,
93
]
} |
the purine bases of the p1 dna showed a lower methylation than those of the s1 dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
27,
30
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
81,
82
]
} |
reduced availability of this pteridine has the potential to reduce the level of the neurotransmitters noradrenaline , adrenaline and 5-hydroxytryptophan in the brain . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
102,
115
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
118,
128
]
} |
accumulation of intra-arterially administered [ 3h ] adrenaline and [ 3h ] noradrenaline in various tissues of the atlantic cod , gadus morhua . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
53,
63
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} |
the accumulation of intra-arterially administered radiolabelled adrenaline and noradrenaline was studied in various tissues of the atlantic cod , gadus morhua . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
79,
92
]
} |
all these tissues , except the heart , also accumulated noradrenaline to a greater extent than adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
56,
69
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} |
small amounts of the injected label ( both adrenaline and noradrenaline ) were also recovered in the intestine , liver and hypothalamus . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
58,
71
]
} |
a methanolic extract of plaice skin , from which lipids had been removed , was chromatographed on alumina , eluted with decreasing concentrations of ethanol . | NA | {
"id": "C0001963",
"name": "methanolic",
"pos": [
2,
12
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
149,
156
]
} |
through pharmacological methods , greater than 95 % of the cholinesterase is judged to be true acetylcholinesterase , and not pseudocholinesterase . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
95,
115
]
} | {
"id": "C0008429",
"name": "pseudocholinesterase",
"pos": [
126,
146
]
} |
based on determinations of total collagen , insoluble collagen , salt-soluble collagen , acid-soluble collagen , protein , total proline , and specific activity of proline and hydroxyproline , there was biochemical evidence of increased collagen synthesis or collagen accumulation in the inflamed lobes on days 4 to 32 as compared to the control lobes . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
129,
136
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
176,
190
]
} |
a 19-year-old woman presented with symptoms of pulmonary infarction and an abnormal perfusion scan compatible with pulmonary embolism . | NA | {
"id": "C0034074",
"name": "pulmonary infarction",
"pos": [
47,
67
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
115,
133
]
} |
hemoptysis , signs of local airway obstruction , or a roentgenogram showing either atelectasis or diffuse lung disease especially favored a positive biopsy . | NA | {
"id": "C0004144",
"name": "atelectasis",
"pos": [
83,
94
]
} | {
"id": "C0024115",
"name": "lung",
"pos": [
106,
110
]
} |
two abundant satellite dna sequences have been identified in and cloned from the dna of triturus cristatus karelinii . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
13,
26
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
81,
84
]
} |
another product of staphylococcus aureus which meets the more recent definition of an enterotoxin is the delta toxin . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
86,
97
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
111,
116
]
} |
an important component of bacterial infection of the gastrointestinal tract , particularly when enterotoxin disruption of gut function occurs , relates to the interaction of the bacterium and toxin with the intestinal surface . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
96,
107
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
192,
197
]
} |
if we expose erythrocyte membranes to cf and the gtp analogue gpp ( nh ) p we can later extract in detergent a factor or complex that confers upon naive erythrocyte membranes the ability to be adp-ribosylated . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
49,
52
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
62,
74
]
} |
these results indicate that stb initiates intestinal secretion in porcine jejunum in vitro by stimulating primarily non-chloride anion secretion in the absence of extracellular calcium . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
120,
128
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
129,
134
]
} |
beer and ethanol were tested in the rat-dimethylhydrazine ( dmh ) experimental carcinogenesis model in order to verify this observation . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
0,
4
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
9,
16
]
} |
after this time , lh beta mrna amounts continue to increase despite a dramatic fall in both serum and pituitary lh . | NA | {
"id": "C0065261",
"name": "lh beta",
"pos": [
18,
25
]
} | {
"id": "C0023607",
"name": "pituitary lh",
"pos": [
102,
114
]
} |
these results suggest that lh beta mrna amounts are regulated during the lh preovulatory surge . | NA | {
"id": "C0065261",
"name": "lh beta",
"pos": [
27,
34
]
} | {
"id": "C0023607",
"name": "lh",
"pos": [
73,
75
]
} |
the value of a mixture of cassia and citronella oils for detection of hypersensitivity of essential oils . | NA | {
"id": "C0028908",
"name": "oils",
"pos": [
48,
52
]
} | {
"id": "C0028910",
"name": "oils",
"pos": [
100,
104
]
} |
thrombo-embolism had recurred in 14 % of 204 patients who had been re-examined , in 9 % thrombosis , in 3 % pulmonary embolism , and in 2 % both . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
8,
16
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
108,
126
]
} |
[ expression of fc- and c3-receptors on membranes of blast cells in myeloblastic leukemia and blast crisis of myelocytic leukemia ] . | NA | {
"id": "C0023479",
"name": "myeloblastic",
"pos": [
68,
80
]
} | {
"id": "C0023470",
"name": "myelocytic leukemia",
"pos": [
110,
129
]
} |
the processing of eegs with respect to epileptic seizures falls in two main categories : automatic recognition of seizures during long-term monitoring and analysis of seizures to extract information not available from visual inspection . | NA | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
39,
57
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
167,
175
]
} |
this is important for the identification of seizure type , the differentiation between epileptic and non-epileptic seizures and the preoperative localization of seizure onset . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
44,
51
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
105,
114
]
} |
conversely diagnostic eeg and monitoring studies may be required to classify seizures as an aid to determining appropriate medication and may explain apparent resistance to therapy , due to pseudo-seizures , reflex or self-induced epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
77,
85
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
231,
239
]
} |
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