text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
one hundred fifty-one cycles in 134 consecutive patients were stimulated with 150 iu of human urinary follicle-stimulating hormone ( fsh ) and 150 iu of human menopausal gonadotropin ( hmg ) on cycle days 3 and 4 and then with 150 iu of hmg daily for the purpose of multiple follicular development for in vitro fertiliza... | NA | {
"id": "C0524639",
"name": "human urinary follicle-stimulating hormone",
"pos": [
88,
130
]
} | {
"id": "C0025326",
"name": "hmg",
"pos": [
237,
240
]
} |
total cholesterol , triglycerides , and phospholipids were determined in whole serum and in the following lipoprotein fractions : very low-density lipoproteins ( vldl ) , low-density lipoproteins ( ldl ) , and high-density lipoproteins , obtained by ultracentrifugation . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
106,
117
]
} | {
"id": "C0023825",
"name": "very low-density lipoproteins",
"pos": [
130,
159
]
} |
[ clinical application of serum insulin-like growth factor i ( igf-i ) ( 26-46 ) radioimmunoassay -- with special reference to the relationship between igf ( 26-46 ) and growth hormone secretion ] . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
63,
68
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
152,
155
]
} |
interactions between antiserum ( rabbit anti-human normal thyroglobulin-serum ) and human thyroglobulin preparations ( obtained from the tissues of the normal thyroid gland , thyroid adenoma , and carcinoma ) were compared by inhibition effect with the binding between 131i-labeled standard thyroglobulin and antiserum ,... | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
21,
30
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
340,
348
]
} |
ketoconazole also inhibited 18-hydroxylation of corticosterone to form 18-hydroxycorticosterone , with 50 % inhibitory concentration of less than 0.03 microgram/ml . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
48,
62
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
71,
95
]
} |
thus , in a series of reaction steps , the inhibitory effect of corticosterone to 18-hydroxycorticosterone was more potent than deoxycorticosterone to 18-hydroxycorticosterone reaction . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
64,
78
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
151,
175
]
} |
during insulin deprivation plasma epinephrine and norepinephrine increased slightly ( from 107 +/- 10 ng/l to 173 +/- 6 ng/l and from 307 +/- 37 ng/l to 518 +/- 77/ng/l respectively ( p less than 0.05 ) , cortisol decreased physiologically , but growth hormone and glucagon were not significantly modified . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
34,
45
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
50,
64
]
} |
the addition of propranolol to insulin deprivation did not modify the changes in hormone concentrations in spite of a slightly greater rise of epinephrine ( from 78 +/- 4 ng/l to 179 +/- 7 ng/l , p less than 0.05 ) and norepinephrine ( from 395 +/- 80 ng/l to 679 +/- 153 ng/l , p less than 0.05 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
143,
154
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
219,
233
]
} |
with 0.5 % dmso , cells remained viable for at least 8 weeks , but while some appeared to have smaller nuclei and retained their rounded appearance , others became fibroblastic within several days and adhered to the culture vessel . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
164,
176
]
} |
four glycosidases ( beta-galactosidase , alpha-mannosidase , alpha-fucosidase and beta-n-acetylglucosaminidase ) were studied in chicken normal and regenerating liver , in turkey poult liver and in virus induced avian tumors -- chicken hepatoma ( strain mc-29 ) , rous sarcoma ( strain schmidt-ruppin ) and turkey poult ... | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
5,
17
]
} | {
"id": "C0016787",
"name": "alpha-fucosidase",
"pos": [
61,
77
]
} |
acute effect of triiodothyronine on the dynamics of thyrotropin release from superfused anterior pituitary cells . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
52,
63
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
88,
106
]
} |
in this system , monovalent anions augment the smprl-receptor interaction in the order f- greater than cl- greater than br- greater than i- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
28,
34
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
87,
88
]
} |
in this system , monovalent anions augment the smprl-receptor interaction in the order f- greater than cl- greater than br- greater than i- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
28,
34
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
137,
138
]
} |
during commencement the synthesis of 19 proteins begins , the relative rate of synthesis of 21 other proteins increases , and 16 proteins show a rapid decrease in their synthetic rate . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
24,
33
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} |
in general , synthesis of spore-cell specific proteins begins just following the formation of tight aggregates while stalk-cell specific proteins are induced during culmination . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
13,
22
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
137,
145
]
} |
mesenchymal cells , which do not normally contain keratins , can be induced by the inhibitor of dna methylation 5-azacytidine to synthesize the basic keratin endo a . | NA | {
"id": "C0010803",
"name": "keratins",
"pos": [
50,
58
]
} | {
"id": "C1179973",
"name": "basic keratin",
"pos": [
144,
157
]
} |
two of the antibodies raised cross react with the small heat-shock proteins hsp 28/27 and hsp 23 . | NA | {
"id": "C1564779",
"name": "small heat-shock proteins",
"pos": [
50,
75
]
} | {
"id": "C0018847",
"name": "hsp",
"pos": [
90,
93
]
} |
this monoclonal antibody can bind to the relevant epitope of the circulating antigen or to the antigenic determinants of the immune complexes that remained exposed in the complex . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
77,
84
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
95,
117
]
} |
rats were cannulated 16 h after the last period of exercise and blood sampling was obtained 48 h later for basal plasma glucose , insulin , epinephrine , and norepinephrine determination . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
158,
172
]
} |
in the isolated rat pancreas perfused with 2.8 mmol/l glucose , the continuous perfusion of 2-cp ( 1 mmol/l ) starting before an infusion of arginine or alanine ( 5 mmol/l ) considerably reduced the hypersecretion of glucagon evoked by these amino acids ( p less than 0.001 ) . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
153,
160
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
242,
253
]
} |
the rise in sli after the meal was due to an increase of sli co-eluting with somatostatin-28 and somatostatin-14 . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
77,
92
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
97,
112
]
} |
oral glucose administration ( 75 g ) to eight healthy , adult subjects induced predictable increases in concentrations of blood glucose and immunoreactive insulin . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
5,
12
]
} | {
"id": "C0005802",
"name": "in",
"pos": [
160,
162
]
} |
ten millimolar theophylline or 1 mm 1-methyl-3-isobutylxanthine , which inhibit camp phosphodiesterase , each greatly increased the stimulation of insulin release by 59-801 . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
15,
27
]
} | {
"id": "C0000096",
"name": "1",
"pos": [
171,
172
]
} |
igf activity in the igf pool was demonstrated by a specific radioreceptor assay using rat liver plasma membranes and 125i-labeled rat igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
0,
3
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
134,
140
]
} |
the igf in islet cell media was characterized further by radioimmunoassays specific for human igf-i and for rat igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
4,
7
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
112,
117
]
} |
the igf in islet cell media was characterized further by radioimmunoassays specific for human igf-i and for rat igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
4,
7
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
112,
118
]
} |
islet cell igf was identified as predominantly igf-i or a closely related species and not igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
11,
14
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
90,
95
]
} |
islet cell igf was identified as predominantly igf-i or a closely related species and not igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
11,
14
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
90,
96
]
} |
but the glycoconjugates constituting all the fr-1 of group ii were identified as glycoproteins and incorporating 35s only to a small extent were identified as sulfated glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
8,
23
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
168,
181
]
} |
this finding is more often observed in patients with infarction of the posterior wall , in whom anterior st depression on exercise might be due to ischemia or dyssynergy of the infarcted area . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
53,
63
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
147,
155
]
} |
serious arrhythmias complicated the early phase of acute myocardial infarction , but only sinus bradycardia seems to have a significant predicativity of ventricular fibrillation ( p less than 0.05 ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
8,
19
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
153,
164
]
} |
regional abnormalities on the phase-amplitude images from the 15 degrees caudal left anterior oblique view scans were studied in order to identify local hypokinesis , akinesis or dyskinesis ( in accord to definitions used for contrast cineangiography ) relative to seven conventional left ventricular wall segments . | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
153,
164
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
179,
189
]
} |
a modified nucleic acid base was isolated from liver dna of rats treated with 1-nitropyrene . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
11,
23
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
53,
56
]
} |
numerous false positive results were encountered in the ca 19.9 assay in pulmonary diseases and in non-cancerous liver diseases , especially cirrhosis . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
113,
127
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
141,
150
]
} |
of these , 17 ( 71 % ) showed evidence for hepatitis b infection and 15 ( 62.5 % ) became chronic hepatitis b virus carriers . | NA | {
"id": "C0019163",
"name": "hepatitis b infection",
"pos": [
43,
64
]
} | {
"id": "C0524909",
"name": "chronic hepatitis b",
"pos": [
90,
109
]
} |
by contrast , intravenous infusion of bombesin stimulated both gastrin release and acid secretion without affecting the acid response to a submaximal dose of pentagastrin . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
63,
70
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
158,
170
]
} |
the immunoreactive neuropeptides demonstrated included vasoactive intestinal polypeptide ( vip ) , peptide histidine isoleucine ( phi ) , gastrin-releasing peptide ( grp ) , substance p ( sp ) , enkephalin , somatostatin , cholecystokinin , and neuropeptide y ( npy ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
19,
32
]
} | {
"id": "C0030947",
"name": "peptide histidine isoleucine",
"pos": [
99,
127
]
} |
the immunoreactive neuropeptides demonstrated included vasoactive intestinal polypeptide ( vip ) , peptide histidine isoleucine ( phi ) , gastrin-releasing peptide ( grp ) , substance p ( sp ) , enkephalin , somatostatin , cholecystokinin , and neuropeptide y ( npy ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
19,
32
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
245,
259
]
} |
these results support the hypothesis that psp is a molecular entity , and not a degradation product of trypsinogen 1 or another pancreatic protein . | NA | {
"id": "C0075269",
"name": "psp",
"pos": [
42,
45
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} |
pancreatic stone protein , a novel protein isolated from pancreatic stones of patients suffering from chronic calcifying pancreatitis and secreted in normal human pancreatic juice , was measured by radial immunodiffusion in pure pancreatic juice . | NA | {
"id": "C0075269",
"name": "pancreatic stone protein",
"pos": [
0,
24
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
35,
42
]
} |
the maximum concentration of epitestosterone in blood , measured by radioimmunoassay , was four times that of testosterone ( approximately 900 and 200 nmol/l , respectively ) . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
29,
44
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
110,
122
]
} |
the maximum testicular concentrations ( pmol/testis ) were 390 ( nonincubated ) and 2050 ( incubated ) for epitestosterone , and 2025 ( nonincubated ) and 1040 ( incubated ) for testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
107,
122
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
178,
190
]
} |
5-ene-3beta-hydroxysteroid dehydrogenase ( 5-ene-3beta-hsd ) was found to have a different michaelis-menten constant ( km ) for each of three 5-ene-3beta-hydroxysteroids , ( pregnenolone ( p5 ) , 17alpha-hydroxypregnenolone ( 17alpha-p5 ) , and dehydroepiandrosterone ( dha ) but the constant for 17beta-hydroxysteroid d... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
174,
186
]
} | {
"id": "C0376260",
"name": "17alpha-hydroxypregnenolone",
"pos": [
196,
223
]
} |
this has enabled us to demonstrate a 16-fold amplification of the genomic dna sequences at these regions during dna-puffing . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
comparison of the amino acid compositions of the 1c and fima subunit proteins with those of the f72 and papa proteins ( subunits for p-fimbriae ) revealed that homology between these two sets of fimbrial subunits is also maximal at the n- and c-termini . | NA | {
"id": "C0599220",
"name": "subunit proteins",
"pos": [
61,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
109,
117
]
} |
the gene is included within a 3.6-kb fragment and confers production of extracellular amylo-alpha-1,4-glucosidase ( amg ) and , thereby the ability to hydrolyse starch or dextrins on dex- strains of saccharomyces cerevisiae . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
161,
167
]
} | {
"id": "C0011808",
"name": "dextrins",
"pos": [
171,
179
]
} |
the results illustrate the involvement of macrophage-series cells , fibroblasts , lymphocytes and mast cells in neovascularisation , atrophy of the retinal pigment epithelium and the breakdown of bruch 's membrane . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} |
the transfer of syrian golden hamsters from a long to a short photoperiod ( sp ) leads to reduced circulating levels of several anterior pituitary hormones including thyrotropin stimulating hormone ( tsh ) , luetinizing hormone ( lh ) and follicle stimulating hormone ( fsh ) , while growth hormone ( gh ) is unaffected ... | NA | {
"id": "C0032016",
"name": "anterior pituitary hormones",
"pos": [
128,
155
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
166,
177
]
} |
the transfer of syrian golden hamsters from a long to a short photoperiod ( sp ) leads to reduced circulating levels of several anterior pituitary hormones including thyrotropin stimulating hormone ( tsh ) , luetinizing hormone ( lh ) and follicle stimulating hormone ( fsh ) , while growth hormone ( gh ) is unaffected ... | NA | {
"id": "C0032016",
"name": "anterior pituitary hormones",
"pos": [
128,
155
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
284,
298
]
} |
the activity of an interferon induced enzyme , ( 2',5 ' ) oligo adenylate synthetase , was determined in peripheral blood mononuclear cells and granulocytes of patients with inflammatory bowel disease and compared with its activity in cells isolated from normal subjects . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
105,
139
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
235,
240
]
} |
the low ( 2',5 ' ) oligo adenylate synthetase activity in peripheral blood mononuclear cells and granulocytes of patients with active inflammatory bowel disease may reflect decreased cellular response to interferon or a difference in the type of interferon elevated in viral diseases and in inflammatory bowel disease . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
58,
74
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
183,
191
]
} |
binding of complexes to fdc causes germinal centre enlargement and is a very efficient , and possibly essential stimulus to the generation of b memory cells which recognize epitopes on antigen or antibody in the complexes . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
173,
181
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
185,
192
]
} |
baby hamster kidney fibroblasts ( bhk-21/c13 ) and early ( keller ) and late ( mrc-5 ) passage human fibroblasts were used to measure cell detachment , cloning efficiency , and growth inhibition under subconfluent culture conditions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
134,
138
]
} |
usually they die from drowning at home or in a natural body of water , commonly drugs or alcohol are involved ; | NA | {
"id": "C0011065",
"name": "die",
"pos": [
13,
16
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
22,
30
]
} |
cimetidine maintenance treatment has no effect on sexual activity , the quality of seminal fluid or the pituitary secretion of gonadotropins or prolactin . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
104,
113
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
144,
153
]
} |
rats fed the srd presented glucose intolerance after i.v . glucose ( kg x 10 ( -2 ) ; 1.06 +/- 0.09 vs 2.61 +/- 0.14 of std , p less than 0.001 ) in spite of the presence of hyperinsulinism ( sigma plasma iri microu/ml from 0 to 30 min : 184.6 +/- 23.6 vs 100.5 +/- 9.7 of std , p less than 0.01 ) suggesting that a stat... | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
174,
189
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
325,
343
]
} |
it was concluded that this lactogen-dependent tumor contains steroid receptors with molecular properties similar to those of normal target tissues , including estrogen receptors capable of nuclear translocation , the levels of which are modulated by the specific growth conditions . | NA | {
"id": "C0034840",
"name": "steroid",
"pos": [
61,
68
]
} | {
"id": "C0034804",
"name": "estrogen receptors",
"pos": [
159,
177
]
} |
patients recovering from acute surgical stress often excrete increased 17-oh corticosteroids with no change in 17-ketosteroids . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
77,
92
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
111,
126
]
} |
threonine and alanine are quantitatively the most important amino acids in both normal and diabetic animals , suggesting a particular role of threonine in amino acid metabolic pathways in the duck . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
14,
21
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
155,
165
]
} |
prolactin was found in 18 of the 21 adenomas carrying the preoperative diagnosis of prolactinoma , whereas cells containing other hormones ( growth hormone , lh , fsh , tsh , acth , beta-endorphin ) , were only occasionally present . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
36,
44
]
} | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
84,
96
]
} |
in adults and in children older than 6 months of age , cbp granules were found almost exclusively in association with four main groups of liver diseases : wilson 's disease , chronic biliary disorders , cirrhosis/extensive fibrosis , and primary liver tumors . | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
135,
152
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
203,
212
]
} |
three clinicopathologic groups were identified : 1 ) patients with collagen vascular diseases , especially rheumatoid arthritis and sjogren 's syndrome ; | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
107,
127
]
} | {
"id": "C1527336",
"name": "sjogren 's",
"pos": [
132,
142
]
} |
ultrastructural study revealed that the basic cell of this lesion had fine structural features of both fibroblast and myofibroblast cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
103,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} |
the only case of a homozygote ss had moderate anemia ( 10.3g hb % ) , 25.7 % of hb f , and a very benign course . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
61,
63
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
80,
84
]
} |
penicillinase ( beta lactamase ) producing strains of neisseria gonorrhoeae ( ppng ) were found in 23 ( 10.5 % ) patients , of whom 10 were treated with augmentin and 13 with amoxycillin . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
0,
13
]
} | {
"id": "C0597979",
"name": "beta lactamase",
"pos": [
16,
30
]
} |
trends in the urinary concentrations of the four arsenic species , pentavalent [ as ( v ) ] and trivalent [ as ( iii ) ] inorganic arsenic , monomethylarsonic acid ( mmaa ) and dimethylarsinic acid ( dmaa ) , were followed for several days subsequent to the acute intoxication of two human subjects by arsenic trioxide [... | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
49,
56
]
} | {
"id": "C0052416",
"name": "arsenic trioxide",
"pos": [
302,
318
]
} |
the isolation of cdna and , in certain cases , genomic clones has been reported for the following complement proteins : c1q , c2 , c3 , c4 , c5 , c9 , and factor b , c4b-binding protein and c1-inhibitor . | NA | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
98,
117
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
155,
163
]
} |
these antigenic determinants on the immunoglobulin are termed the 'idiotype ' , and antibodies directed against them 'anti-idiotype ' . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
6,
28
]
} | {
"id": "C0021013",
"name": "idiotype",
"pos": [
123,
131
]
} |
various components of the phosphatidylcholine molecule , and other lipids including the closely-related molecule dipalmitoyl phosphatidyl-dimethyl-ethanolamine which is identical to dipalmitoyl phosphatidylcholine , except for the absence of a ch2 group on the polar head group , did not inhibit lysis by the autoantibod... | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
26,
45
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
182,
193
]
} |
lipopolysaccharides ( lps ) as well as polysaccharide ( ps ) moieties of bordetella pertussis and neisseria meningitidis endotoxins induced in vitro interleukin 1 ( il 1 ) secretion by human monocytes as evaluated by the co-mitogenic assay on c3h/hej thymocytes . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
0,
19
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
121,
131
]
} |
it is suggested that the reduced appearance of cells forming antigen-dependent non-specific immunoglobulins is due to suppression either of hypothetic inductors or precursors of these cells , which resemble the precursors of antibody producers in their idiotypes . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
21,
24
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
211,
221
]
} |
the alpha and alpha ' chains were both immunoprecipitated by a monoclonal antibody directed to the ly-2.1 epitope whereas the ly-3.1 antibody bound only the beta chain . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
63,
82
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
133,
141
]
} |
leukotriene d4 , a constituent of slow-reacting substance of anaphylaxis , elicits a pressor response followed by hypotensive shock in spontaneously hypertensive rats but not in other rats . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of slow-reacting substance",
"pos": [
31,
57
]
} |
although most subjects were notably overweight ( mean ideal body weight 177 % ) , the population represented a wide spectrum of body weights and blood pressure levels . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
36,
46
]
} | {
"id": "C0005910",
"name": "body weights",
"pos": [
128,
140
]
} |
recent studies using inhibitors or synthetic substrates of serine protease suggest that membrane protease activity may be essential for neutrophil chemotaxis , phagocytosis , degranulation , and superoxide production . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
59,
74
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
97,
105
]
} |
two endopeptidases were demonstrated : a metalloendopeptidase which accounted for two thirds of the intact cell activity , and a serine endopeptidase , accounting for the rest of the activity . | NA | {
"id": "C0030946",
"name": "endopeptidases",
"pos": [
4,
18
]
} | {
"id": "C1442934",
"name": "metalloendopeptidase",
"pos": [
41,
61
]
} |
the effects of alpha 1-antitrypsin ( alpha 1-at ) , alpha 1-acid glycoprotein ( alpha 1-agp ) , and haptoglobin ( hp ) , the main constituents of alpha-globulin and which belong to acute-phase proteins , on nk activity were examined using k562 cells as the nk target cells . | NA | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
15,
34
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
181,
201
]
} |
the effects of alpha 1-antitrypsin ( alpha 1-at ) , alpha 1-acid glycoprotein ( alpha 1-agp ) , and haptoglobin ( hp ) , the main constituents of alpha-globulin and which belong to acute-phase proteins , on nk activity were examined using k562 cells as the nk target cells . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
52,
77
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
181,
201
]
} |
the effects of alpha 1-antitrypsin ( alpha 1-at ) , alpha 1-acid glycoprotein ( alpha 1-agp ) , and haptoglobin ( hp ) , the main constituents of alpha-globulin and which belong to acute-phase proteins , on nk activity were examined using k562 cells as the nk target cells . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
100,
111
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
181,
201
]
} |
if the patient is critically ill or if there is gross comminution of the femur external fixation is indicated for this fracture as well . | NA | {
"id": "C0476171",
"name": "comminution",
"pos": [
54,
65
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
119,
127
]
} |
hybridoma-derived monoclonal antibodies were prepared against outer membrane antigens of four strains of vibrio cholerae that were cultivated under iron-limited conditions , and these antibodies were partially characterized . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
18,
39
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
184,
194
]
} |
two antigens ( molecular weights , 18,000 and 112,000 ) were heat modifiable , whereas the reacting epitope of a third antigen ( 40,000-dalton-18,000-dalton doublet ) was completely destroyed when it was heated at 100 degrees c . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
100,
107
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
119,
126
]
} |
of these , 12 were cross-reactive with lipopolysaccharides of other gram-negative bacteria , including 2 which recognized lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
39,
58
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
122,
129
]
} |
this finding strongly suggests that the presence of acyloxyacyl groups at the c-2 ' and c-3 ' positions of the disaccharide backbone is one of the most important determinant structures of the lipid a molecule for exhibition of strong biological activities characteristic of lipopolysaccharide and its lipid a moiety . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
274,
292
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
301,
308
]
} |
in view of the fact that mycobacteria uniquely contain large amounts of branched fatty acids , it was proposed that the complex of muramyl dipeptide and branched fatty acids , mostly mycolic acids , is a structure in tubercle bacilli responsible for tubercle formation . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
81,
92
]
} | {
"id": "C0026931",
"name": "mycolic acids",
"pos": [
183,
196
]
} |
gonococci isolated from localized urogenital infections usually possess one or more protein ii ( p.ii ) species in the outer membrane , but the structural and antigenic variation of these proteins among different gonococcal strains has made it difficult to determine if specific proteins of the p.ii class are associated... | NA | {
"id": "C0025252",
"name": "protein",
"pos": [
84,
91
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
279,
287
]
} |
although elastase containing a covalently bound substrate analog no longer binds the pneumococcal inhibitor , the present study shows that complex formation is nevertheless independent of neutrophil elastase catalytic activity . | NA | {
"id": "C0030306",
"name": "elastase",
"pos": [
9,
17
]
} | {
"id": "C0064833",
"name": "neutrophil elastase",
"pos": [
188,
207
]
} |
a novel system was used previously to characterize the dynamic interaction of a polysaccharide-deficient , lipid-rich lipopolysaccharide ( lps ) with rabbit erythrocytes ( rarbc ) . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
118,
136
]
} |
( 2 ) its close association with a platelet membrane glycoprotein of essential functional importance , the gpiib-iiia complex ; | NA | {
"id": "C0032195",
"name": "platelet membrane glycoprotein",
"pos": [
35,
65
]
} | {
"id": "C0016011",
"name": "gpiib-iiia complex",
"pos": [
107,
125
]
} |
the fact that spores contain unique antigens suggests that basidiospores may be the best source of relevant allergens for clinical studies . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
36,
44
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
108,
117
]
} |
we determined the serotonin ( 5-hydroxytryptamine , 5ht ) content of growth factor dependent mouse mast cell lines or clones , and measured their ability to synthesize and store 3h-5ht from exogenous 5-hydroxy- [ g-3h ] -tryptophan ( 3h-5htp ) in vitro . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
221,
231
]
} | {
"id": "C0000578",
"name": "5htp",
"pos": [
237,
241
]
} |
this was shown by the binding of heterologous antiidiotypic antibodies , produced against anti-pla igg from single donors , to anti-pla f ( ab ' ) 2 of different individuals . | NA | {
"id": "C0003248",
"name": "heterologous",
"pos": [
33,
45
]
} | {
"id": "C0003241",
"name": "anti-pla",
"pos": [
127,
135
]
} |
the study shows the possibility to stimulate the maturation of basophil/mast cell precursor cells present in the blood of allergic and healthy individuals with antigen-induced factors . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
82,
97
]
} |
activated eosinophils and secreted ecp were found together in ( 1 ) skin lesions of patients with chronic urticaria , ( 2 ) gut lesions of patients with eosinophilic gastroenteritis and ulcerative colitis , and ( 3 ) tissues containing granulomas in patients with allergic granulomatosis and vasculitis - the churg and s... | NA | {
"id": "C0018188",
"name": "granulomas",
"pos": [
236,
246
]
} | {
"id": "C0008728",
"name": "allergic granulomatosis",
"pos": [
264,
287
]
} |
factors traditionally associated with histamine release include ige antibody plus antigen and the anaphylatoxins c3a , c4a , and c5a . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
98,
112
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
113,
116
]
} |
using high performance liquid chromatography we have separated bradykinin from kallidin , des-arg9-bradykinin ( the degradation product of carboxypeptidase n ) as well as the fragments arg-pro-pro-gly-phe , ser-pro , and phe-arg , the degradation products formed by angiotensin-converting enzyme . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
79,
87
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
99,
109
]
} |
this compound also reduced leukotriene d4- and platelet-activating factor-induced bronchoconstriction in guinea pigs , strongly suggesting an antagonistic activity against slow reacting substance of anaphylaxis ( srs-a ) . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
27,
41
]
} | {
"id": "C0038091",
"name": "slow reacting",
"pos": [
172,
185
]
} |
in contrast , when mmc alone was administered , putrescine and spermidine levels in the tumor did not differ from those in control mice . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
48,
58
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
74,
80
]
} |
we recorded ventricular activation sequence during ventricular tachycardia in 76 patients who underwent surgical therapy of refractory ventricular tachycardia . | NA | {
"id": "C0042514",
"name": "ventricular",
"pos": [
12,
23
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
147,
158
]
} |
lactate levels ( +30 % ) as well as noradrenaline and adrenaline responses ( +60 % -90 % ) were higher in the cumulative experiment ( test 1 ) at work loads corresponding to 70 % -80 % of the oxygen uptake capacity as compared to the noncumulative testing procedure ( test 2 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
54,
64
]
} |
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