text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
one hundred fifty-one cycles in 134 consecutive patients were stimulated with 150 iu of human urinary follicle-stimulating hormone ( fsh ) and 150 iu of human menopausal gonadotropin ( hmg ) on cycle days 3 and 4 and then with 150 iu of hmg daily for the purpose of multiple follicular development for in vitro fertilization ( ivf ) . | NA | {
"id": "C0524639",
"name": "human urinary follicle-stimulating hormone",
"pos": [
88,
130
]
} | {
"id": "C0025326",
"name": "hmg",
"pos": [
237,
240
]
} |
total cholesterol , triglycerides , and phospholipids were determined in whole serum and in the following lipoprotein fractions : very low-density lipoproteins ( vldl ) , low-density lipoproteins ( ldl ) , and high-density lipoproteins , obtained by ultracentrifugation . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
106,
117
]
} | {
"id": "C0023825",
"name": "very low-density lipoproteins",
"pos": [
130,
159
]
} |
[ clinical application of serum insulin-like growth factor i ( igf-i ) ( 26-46 ) radioimmunoassay -- with special reference to the relationship between igf ( 26-46 ) and growth hormone secretion ] . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
63,
68
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
152,
155
]
} |
interactions between antiserum ( rabbit anti-human normal thyroglobulin-serum ) and human thyroglobulin preparations ( obtained from the tissues of the normal thyroid gland , thyroid adenoma , and carcinoma ) were compared by inhibition effect with the binding between 131i-labeled standard thyroglobulin and antiserum , set up by a double antibody ria . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
21,
30
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
340,
348
]
} |
ketoconazole also inhibited 18-hydroxylation of corticosterone to form 18-hydroxycorticosterone , with 50 % inhibitory concentration of less than 0.03 microgram/ml . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
48,
62
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
71,
95
]
} |
thus , in a series of reaction steps , the inhibitory effect of corticosterone to 18-hydroxycorticosterone was more potent than deoxycorticosterone to 18-hydroxycorticosterone reaction . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
64,
78
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
151,
175
]
} |
during insulin deprivation plasma epinephrine and norepinephrine increased slightly ( from 107 +/- 10 ng/l to 173 +/- 6 ng/l and from 307 +/- 37 ng/l to 518 +/- 77/ng/l respectively ( p less than 0.05 ) , cortisol decreased physiologically , but growth hormone and glucagon were not significantly modified . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
34,
45
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
50,
64
]
} |
the addition of propranolol to insulin deprivation did not modify the changes in hormone concentrations in spite of a slightly greater rise of epinephrine ( from 78 +/- 4 ng/l to 179 +/- 7 ng/l , p less than 0.05 ) and norepinephrine ( from 395 +/- 80 ng/l to 679 +/- 153 ng/l , p less than 0.05 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
143,
154
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
219,
233
]
} |
with 0.5 % dmso , cells remained viable for at least 8 weeks , but while some appeared to have smaller nuclei and retained their rounded appearance , others became fibroblastic within several days and adhered to the culture vessel . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
164,
176
]
} |
four glycosidases ( beta-galactosidase , alpha-mannosidase , alpha-fucosidase and beta-n-acetylglucosaminidase ) were studied in chicken normal and regenerating liver , in turkey poult liver and in virus induced avian tumors -- chicken hepatoma ( strain mc-29 ) , rous sarcoma ( strain schmidt-ruppin ) and turkey poult hemocytoblastoma nodules ( strain mc-31 ) . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
5,
17
]
} | {
"id": "C0016787",
"name": "alpha-fucosidase",
"pos": [
61,
77
]
} |
acute effect of triiodothyronine on the dynamics of thyrotropin release from superfused anterior pituitary cells . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
52,
63
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
88,
106
]
} |
in this system , monovalent anions augment the smprl-receptor interaction in the order f- greater than cl- greater than br- greater than i- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
28,
34
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
87,
88
]
} |
in this system , monovalent anions augment the smprl-receptor interaction in the order f- greater than cl- greater than br- greater than i- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
28,
34
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
137,
138
]
} |
during commencement the synthesis of 19 proteins begins , the relative rate of synthesis of 21 other proteins increases , and 16 proteins show a rapid decrease in their synthetic rate . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
24,
33
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
129,
137
]
} |
in general , synthesis of spore-cell specific proteins begins just following the formation of tight aggregates while stalk-cell specific proteins are induced during culmination . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
13,
22
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
137,
145
]
} |
mesenchymal cells , which do not normally contain keratins , can be induced by the inhibitor of dna methylation 5-azacytidine to synthesize the basic keratin endo a . | NA | {
"id": "C0010803",
"name": "keratins",
"pos": [
50,
58
]
} | {
"id": "C1179973",
"name": "basic keratin",
"pos": [
144,
157
]
} |
two of the antibodies raised cross react with the small heat-shock proteins hsp 28/27 and hsp 23 . | NA | {
"id": "C1564779",
"name": "small heat-shock proteins",
"pos": [
50,
75
]
} | {
"id": "C0018847",
"name": "hsp",
"pos": [
90,
93
]
} |
this monoclonal antibody can bind to the relevant epitope of the circulating antigen or to the antigenic determinants of the immune complexes that remained exposed in the complex . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
77,
84
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
95,
117
]
} |
rats were cannulated 16 h after the last period of exercise and blood sampling was obtained 48 h later for basal plasma glucose , insulin , epinephrine , and norepinephrine determination . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
158,
172
]
} |
in the isolated rat pancreas perfused with 2.8 mmol/l glucose , the continuous perfusion of 2-cp ( 1 mmol/l ) starting before an infusion of arginine or alanine ( 5 mmol/l ) considerably reduced the hypersecretion of glucagon evoked by these amino acids ( p less than 0.001 ) . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
153,
160
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
242,
253
]
} |
the rise in sli after the meal was due to an increase of sli co-eluting with somatostatin-28 and somatostatin-14 . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
77,
92
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
97,
112
]
} |
oral glucose administration ( 75 g ) to eight healthy , adult subjects induced predictable increases in concentrations of blood glucose and immunoreactive insulin . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
5,
12
]
} | {
"id": "C0005802",
"name": "in",
"pos": [
160,
162
]
} |
ten millimolar theophylline or 1 mm 1-methyl-3-isobutylxanthine , which inhibit camp phosphodiesterase , each greatly increased the stimulation of insulin release by 59-801 . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
15,
27
]
} | {
"id": "C0000096",
"name": "1",
"pos": [
171,
172
]
} |
igf activity in the igf pool was demonstrated by a specific radioreceptor assay using rat liver plasma membranes and 125i-labeled rat igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
0,
3
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
134,
140
]
} |
the igf in islet cell media was characterized further by radioimmunoassays specific for human igf-i and for rat igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
4,
7
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
112,
117
]
} |
the igf in islet cell media was characterized further by radioimmunoassays specific for human igf-i and for rat igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
4,
7
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
112,
118
]
} |
islet cell igf was identified as predominantly igf-i or a closely related species and not igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
11,
14
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
90,
95
]
} |
islet cell igf was identified as predominantly igf-i or a closely related species and not igf-ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
11,
14
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
90,
96
]
} |
but the glycoconjugates constituting all the fr-1 of group ii were identified as glycoproteins and incorporating 35s only to a small extent were identified as sulfated glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
8,
23
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
168,
181
]
} |
this finding is more often observed in patients with infarction of the posterior wall , in whom anterior st depression on exercise might be due to ischemia or dyssynergy of the infarcted area . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
53,
63
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
147,
155
]
} |
serious arrhythmias complicated the early phase of acute myocardial infarction , but only sinus bradycardia seems to have a significant predicativity of ventricular fibrillation ( p less than 0.05 ) . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
8,
19
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
153,
164
]
} |
regional abnormalities on the phase-amplitude images from the 15 degrees caudal left anterior oblique view scans were studied in order to identify local hypokinesis , akinesis or dyskinesis ( in accord to definitions used for contrast cineangiography ) relative to seven conventional left ventricular wall segments . | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
153,
164
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
179,
189
]
} |
a modified nucleic acid base was isolated from liver dna of rats treated with 1-nitropyrene . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
11,
23
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
53,
56
]
} |
numerous false positive results were encountered in the ca 19.9 assay in pulmonary diseases and in non-cancerous liver diseases , especially cirrhosis . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
113,
127
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
141,
150
]
} |
of these , 17 ( 71 % ) showed evidence for hepatitis b infection and 15 ( 62.5 % ) became chronic hepatitis b virus carriers . | NA | {
"id": "C0019163",
"name": "hepatitis b infection",
"pos": [
43,
64
]
} | {
"id": "C0524909",
"name": "chronic hepatitis b",
"pos": [
90,
109
]
} |
by contrast , intravenous infusion of bombesin stimulated both gastrin release and acid secretion without affecting the acid response to a submaximal dose of pentagastrin . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
63,
70
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
158,
170
]
} |
the immunoreactive neuropeptides demonstrated included vasoactive intestinal polypeptide ( vip ) , peptide histidine isoleucine ( phi ) , gastrin-releasing peptide ( grp ) , substance p ( sp ) , enkephalin , somatostatin , cholecystokinin , and neuropeptide y ( npy ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
19,
32
]
} | {
"id": "C0030947",
"name": "peptide histidine isoleucine",
"pos": [
99,
127
]
} |
the immunoreactive neuropeptides demonstrated included vasoactive intestinal polypeptide ( vip ) , peptide histidine isoleucine ( phi ) , gastrin-releasing peptide ( grp ) , substance p ( sp ) , enkephalin , somatostatin , cholecystokinin , and neuropeptide y ( npy ) . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
19,
32
]
} | {
"id": "C0027893",
"name": "neuropeptide y",
"pos": [
245,
259
]
} |
these results support the hypothesis that psp is a molecular entity , and not a degradation product of trypsinogen 1 or another pancreatic protein . | NA | {
"id": "C0075269",
"name": "psp",
"pos": [
42,
45
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} |
pancreatic stone protein , a novel protein isolated from pancreatic stones of patients suffering from chronic calcifying pancreatitis and secreted in normal human pancreatic juice , was measured by radial immunodiffusion in pure pancreatic juice . | NA | {
"id": "C0075269",
"name": "pancreatic stone protein",
"pos": [
0,
24
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
35,
42
]
} |
the maximum concentration of epitestosterone in blood , measured by radioimmunoassay , was four times that of testosterone ( approximately 900 and 200 nmol/l , respectively ) . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
29,
44
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
110,
122
]
} |
the maximum testicular concentrations ( pmol/testis ) were 390 ( nonincubated ) and 2050 ( incubated ) for epitestosterone , and 2025 ( nonincubated ) and 1040 ( incubated ) for testosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
107,
122
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
178,
190
]
} |
5-ene-3beta-hydroxysteroid dehydrogenase ( 5-ene-3beta-hsd ) was found to have a different michaelis-menten constant ( km ) for each of three 5-ene-3beta-hydroxysteroids , ( pregnenolone ( p5 ) , 17alpha-hydroxypregnenolone ( 17alpha-p5 ) , and dehydroepiandrosterone ( dha ) but the constant for 17beta-hydroxysteroid dehydrogenase ( 17beta-hsd ) was similar for both the substrates androstendione ( a-dione ) and estradiol-17beta ( e2 ) . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
174,
186
]
} | {
"id": "C0376260",
"name": "17alpha-hydroxypregnenolone",
"pos": [
196,
223
]
} |
this has enabled us to demonstrate a 16-fold amplification of the genomic dna sequences at these regions during dna-puffing . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
} |
comparison of the amino acid compositions of the 1c and fima subunit proteins with those of the f72 and papa proteins ( subunits for p-fimbriae ) revealed that homology between these two sets of fimbrial subunits is also maximal at the n- and c-termini . | NA | {
"id": "C0599220",
"name": "subunit proteins",
"pos": [
61,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
109,
117
]
} |
the gene is included within a 3.6-kb fragment and confers production of extracellular amylo-alpha-1,4-glucosidase ( amg ) and , thereby the ability to hydrolyse starch or dextrins on dex- strains of saccharomyces cerevisiae . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
161,
167
]
} | {
"id": "C0011808",
"name": "dextrins",
"pos": [
171,
179
]
} |
the results illustrate the involvement of macrophage-series cells , fibroblasts , lymphocytes and mast cells in neovascularisation , atrophy of the retinal pigment epithelium and the breakdown of bruch 's membrane . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
68,
79
]
} |
the transfer of syrian golden hamsters from a long to a short photoperiod ( sp ) leads to reduced circulating levels of several anterior pituitary hormones including thyrotropin stimulating hormone ( tsh ) , luetinizing hormone ( lh ) and follicle stimulating hormone ( fsh ) , while growth hormone ( gh ) is unaffected . | NA | {
"id": "C0032016",
"name": "anterior pituitary hormones",
"pos": [
128,
155
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
166,
177
]
} |
the transfer of syrian golden hamsters from a long to a short photoperiod ( sp ) leads to reduced circulating levels of several anterior pituitary hormones including thyrotropin stimulating hormone ( tsh ) , luetinizing hormone ( lh ) and follicle stimulating hormone ( fsh ) , while growth hormone ( gh ) is unaffected . | NA | {
"id": "C0032016",
"name": "anterior pituitary hormones",
"pos": [
128,
155
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
284,
298
]
} |
the activity of an interferon induced enzyme , ( 2',5 ' ) oligo adenylate synthetase , was determined in peripheral blood mononuclear cells and granulocytes of patients with inflammatory bowel disease and compared with its activity in cells isolated from normal subjects . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
105,
139
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
235,
240
]
} |
the low ( 2',5 ' ) oligo adenylate synthetase activity in peripheral blood mononuclear cells and granulocytes of patients with active inflammatory bowel disease may reflect decreased cellular response to interferon or a difference in the type of interferon elevated in viral diseases and in inflammatory bowel disease . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
58,
74
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
183,
191
]
} |
binding of complexes to fdc causes germinal centre enlargement and is a very efficient , and possibly essential stimulus to the generation of b memory cells which recognize epitopes on antigen or antibody in the complexes . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
173,
181
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
185,
192
]
} |
baby hamster kidney fibroblasts ( bhk-21/c13 ) and early ( keller ) and late ( mrc-5 ) passage human fibroblasts were used to measure cell detachment , cloning efficiency , and growth inhibition under subconfluent culture conditions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
134,
138
]
} |
usually they die from drowning at home or in a natural body of water , commonly drugs or alcohol are involved ; | NA | {
"id": "C0011065",
"name": "die",
"pos": [
13,
16
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
22,
30
]
} |
cimetidine maintenance treatment has no effect on sexual activity , the quality of seminal fluid or the pituitary secretion of gonadotropins or prolactin . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
104,
113
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
144,
153
]
} |
rats fed the srd presented glucose intolerance after i.v . glucose ( kg x 10 ( -2 ) ; 1.06 +/- 0.09 vs 2.61 +/- 0.14 of std , p less than 0.001 ) in spite of the presence of hyperinsulinism ( sigma plasma iri microu/ml from 0 to 30 min : 184.6 +/- 23.6 vs 100.5 +/- 9.7 of std , p less than 0.01 ) suggesting that a state of insulin resistance had developed . | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
174,
189
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
325,
343
]
} |
it was concluded that this lactogen-dependent tumor contains steroid receptors with molecular properties similar to those of normal target tissues , including estrogen receptors capable of nuclear translocation , the levels of which are modulated by the specific growth conditions . | NA | {
"id": "C0034840",
"name": "steroid",
"pos": [
61,
68
]
} | {
"id": "C0034804",
"name": "estrogen receptors",
"pos": [
159,
177
]
} |
patients recovering from acute surgical stress often excrete increased 17-oh corticosteroids with no change in 17-ketosteroids . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
77,
92
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
111,
126
]
} |
threonine and alanine are quantitatively the most important amino acids in both normal and diabetic animals , suggesting a particular role of threonine in amino acid metabolic pathways in the duck . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
14,
21
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
155,
165
]
} |
prolactin was found in 18 of the 21 adenomas carrying the preoperative diagnosis of prolactinoma , whereas cells containing other hormones ( growth hormone , lh , fsh , tsh , acth , beta-endorphin ) , were only occasionally present . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
36,
44
]
} | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
84,
96
]
} |
in adults and in children older than 6 months of age , cbp granules were found almost exclusively in association with four main groups of liver diseases : wilson 's disease , chronic biliary disorders , cirrhosis/extensive fibrosis , and primary liver tumors . | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
135,
152
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
203,
212
]
} |
three clinicopathologic groups were identified : 1 ) patients with collagen vascular diseases , especially rheumatoid arthritis and sjogren 's syndrome ; | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
107,
127
]
} | {
"id": "C1527336",
"name": "sjogren 's",
"pos": [
132,
142
]
} |
ultrastructural study revealed that the basic cell of this lesion had fine structural features of both fibroblast and myofibroblast cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
103,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
132,
137
]
} |
the only case of a homozygote ss had moderate anemia ( 10.3g hb % ) , 25.7 % of hb f , and a very benign course . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
61,
63
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
80,
84
]
} |
penicillinase ( beta lactamase ) producing strains of neisseria gonorrhoeae ( ppng ) were found in 23 ( 10.5 % ) patients , of whom 10 were treated with augmentin and 13 with amoxycillin . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
0,
13
]
} | {
"id": "C0597979",
"name": "beta lactamase",
"pos": [
16,
30
]
} |
trends in the urinary concentrations of the four arsenic species , pentavalent [ as ( v ) ] and trivalent [ as ( iii ) ] inorganic arsenic , monomethylarsonic acid ( mmaa ) and dimethylarsinic acid ( dmaa ) , were followed for several days subsequent to the acute intoxication of two human subjects by arsenic trioxide [ as ( iii ) 2o3 ] and sodium orthoarsenate [ na2has ( v ) o4 x 7h2o ] , respectively , in unsuccessful suicide attempts . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
49,
56
]
} | {
"id": "C0052416",
"name": "arsenic trioxide",
"pos": [
302,
318
]
} |
the isolation of cdna and , in certain cases , genomic clones has been reported for the following complement proteins : c1q , c2 , c3 , c4 , c5 , c9 , and factor b , c4b-binding protein and c1-inhibitor . | NA | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
98,
117
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
155,
163
]
} |
these antigenic determinants on the immunoglobulin are termed the 'idiotype ' , and antibodies directed against them 'anti-idiotype ' . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
6,
28
]
} | {
"id": "C0021013",
"name": "idiotype",
"pos": [
123,
131
]
} |
various components of the phosphatidylcholine molecule , and other lipids including the closely-related molecule dipalmitoyl phosphatidyl-dimethyl-ethanolamine which is identical to dipalmitoyl phosphatidylcholine , except for the absence of a ch2 group on the polar head group , did not inhibit lysis by the autoantibodies . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
26,
45
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
182,
193
]
} |
lipopolysaccharides ( lps ) as well as polysaccharide ( ps ) moieties of bordetella pertussis and neisseria meningitidis endotoxins induced in vitro interleukin 1 ( il 1 ) secretion by human monocytes as evaluated by the co-mitogenic assay on c3h/hej thymocytes . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
0,
19
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
121,
131
]
} |
it is suggested that the reduced appearance of cells forming antigen-dependent non-specific immunoglobulins is due to suppression either of hypothetic inductors or precursors of these cells , which resemble the precursors of antibody producers in their idiotypes . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
21,
24
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
211,
221
]
} |
the alpha and alpha ' chains were both immunoprecipitated by a monoclonal antibody directed to the ly-2.1 epitope whereas the ly-3.1 antibody bound only the beta chain . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
63,
82
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
133,
141
]
} |
leukotriene d4 , a constituent of slow-reacting substance of anaphylaxis , elicits a pressor response followed by hypotensive shock in spontaneously hypertensive rats but not in other rats . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of slow-reacting substance",
"pos": [
31,
57
]
} |
although most subjects were notably overweight ( mean ideal body weight 177 % ) , the population represented a wide spectrum of body weights and blood pressure levels . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
36,
46
]
} | {
"id": "C0005910",
"name": "body weights",
"pos": [
128,
140
]
} |
recent studies using inhibitors or synthetic substrates of serine protease suggest that membrane protease activity may be essential for neutrophil chemotaxis , phagocytosis , degranulation , and superoxide production . | NA | {
"id": "C0036734",
"name": "serine protease",
"pos": [
59,
74
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
97,
105
]
} |
two endopeptidases were demonstrated : a metalloendopeptidase which accounted for two thirds of the intact cell activity , and a serine endopeptidase , accounting for the rest of the activity . | NA | {
"id": "C0030946",
"name": "endopeptidases",
"pos": [
4,
18
]
} | {
"id": "C1442934",
"name": "metalloendopeptidase",
"pos": [
41,
61
]
} |
the effects of alpha 1-antitrypsin ( alpha 1-at ) , alpha 1-acid glycoprotein ( alpha 1-agp ) , and haptoglobin ( hp ) , the main constituents of alpha-globulin and which belong to acute-phase proteins , on nk activity were examined using k562 cells as the nk target cells . | NA | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
15,
34
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
181,
201
]
} |
the effects of alpha 1-antitrypsin ( alpha 1-at ) , alpha 1-acid glycoprotein ( alpha 1-agp ) , and haptoglobin ( hp ) , the main constituents of alpha-globulin and which belong to acute-phase proteins , on nk activity were examined using k562 cells as the nk target cells . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
52,
77
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
181,
201
]
} |
the effects of alpha 1-antitrypsin ( alpha 1-at ) , alpha 1-acid glycoprotein ( alpha 1-agp ) , and haptoglobin ( hp ) , the main constituents of alpha-globulin and which belong to acute-phase proteins , on nk activity were examined using k562 cells as the nk target cells . | NA | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
100,
111
]
} | {
"id": "C0001347",
"name": "acute-phase proteins",
"pos": [
181,
201
]
} |
if the patient is critically ill or if there is gross comminution of the femur external fixation is indicated for this fracture as well . | NA | {
"id": "C0476171",
"name": "comminution",
"pos": [
54,
65
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
119,
127
]
} |
hybridoma-derived monoclonal antibodies were prepared against outer membrane antigens of four strains of vibrio cholerae that were cultivated under iron-limited conditions , and these antibodies were partially characterized . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
18,
39
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
184,
194
]
} |
two antigens ( molecular weights , 18,000 and 112,000 ) were heat modifiable , whereas the reacting epitope of a third antigen ( 40,000-dalton-18,000-dalton doublet ) was completely destroyed when it was heated at 100 degrees c . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
100,
107
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
119,
126
]
} |
of these , 12 were cross-reactive with lipopolysaccharides of other gram-negative bacteria , including 2 which recognized lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
39,
58
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
122,
129
]
} |
this finding strongly suggests that the presence of acyloxyacyl groups at the c-2 ' and c-3 ' positions of the disaccharide backbone is one of the most important determinant structures of the lipid a molecule for exhibition of strong biological activities characteristic of lipopolysaccharide and its lipid a moiety . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
274,
292
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
301,
308
]
} |
in view of the fact that mycobacteria uniquely contain large amounts of branched fatty acids , it was proposed that the complex of muramyl dipeptide and branched fatty acids , mostly mycolic acids , is a structure in tubercle bacilli responsible for tubercle formation . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
81,
92
]
} | {
"id": "C0026931",
"name": "mycolic acids",
"pos": [
183,
196
]
} |
gonococci isolated from localized urogenital infections usually possess one or more protein ii ( p.ii ) species in the outer membrane , but the structural and antigenic variation of these proteins among different gonococcal strains has made it difficult to determine if specific proteins of the p.ii class are associated with particular sites or types of infection . | NA | {
"id": "C0025252",
"name": "protein",
"pos": [
84,
91
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
279,
287
]
} |
although elastase containing a covalently bound substrate analog no longer binds the pneumococcal inhibitor , the present study shows that complex formation is nevertheless independent of neutrophil elastase catalytic activity . | NA | {
"id": "C0030306",
"name": "elastase",
"pos": [
9,
17
]
} | {
"id": "C0064833",
"name": "neutrophil elastase",
"pos": [
188,
207
]
} |
a novel system was used previously to characterize the dynamic interaction of a polysaccharide-deficient , lipid-rich lipopolysaccharide ( lps ) with rabbit erythrocytes ( rarbc ) . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
118,
136
]
} |
( 2 ) its close association with a platelet membrane glycoprotein of essential functional importance , the gpiib-iiia complex ; | NA | {
"id": "C0032195",
"name": "platelet membrane glycoprotein",
"pos": [
35,
65
]
} | {
"id": "C0016011",
"name": "gpiib-iiia complex",
"pos": [
107,
125
]
} |
the fact that spores contain unique antigens suggests that basidiospores may be the best source of relevant allergens for clinical studies . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
36,
44
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
108,
117
]
} |
we determined the serotonin ( 5-hydroxytryptamine , 5ht ) content of growth factor dependent mouse mast cell lines or clones , and measured their ability to synthesize and store 3h-5ht from exogenous 5-hydroxy- [ g-3h ] -tryptophan ( 3h-5htp ) in vitro . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
221,
231
]
} | {
"id": "C0000578",
"name": "5htp",
"pos": [
237,
241
]
} |
this was shown by the binding of heterologous antiidiotypic antibodies , produced against anti-pla igg from single donors , to anti-pla f ( ab ' ) 2 of different individuals . | NA | {
"id": "C0003248",
"name": "heterologous",
"pos": [
33,
45
]
} | {
"id": "C0003241",
"name": "anti-pla",
"pos": [
127,
135
]
} |
the study shows the possibility to stimulate the maturation of basophil/mast cell precursor cells present in the blood of allergic and healthy individuals with antigen-induced factors . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
82,
97
]
} |
activated eosinophils and secreted ecp were found together in ( 1 ) skin lesions of patients with chronic urticaria , ( 2 ) gut lesions of patients with eosinophilic gastroenteritis and ulcerative colitis , and ( 3 ) tissues containing granulomas in patients with allergic granulomatosis and vasculitis - the churg and strauss syndrome . | NA | {
"id": "C0018188",
"name": "granulomas",
"pos": [
236,
246
]
} | {
"id": "C0008728",
"name": "allergic granulomatosis",
"pos": [
264,
287
]
} |
factors traditionally associated with histamine release include ige antibody plus antigen and the anaphylatoxins c3a , c4a , and c5a . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
98,
112
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
113,
116
]
} |
using high performance liquid chromatography we have separated bradykinin from kallidin , des-arg9-bradykinin ( the degradation product of carboxypeptidase n ) as well as the fragments arg-pro-pro-gly-phe , ser-pro , and phe-arg , the degradation products formed by angiotensin-converting enzyme . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
79,
87
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
99,
109
]
} |
this compound also reduced leukotriene d4- and platelet-activating factor-induced bronchoconstriction in guinea pigs , strongly suggesting an antagonistic activity against slow reacting substance of anaphylaxis ( srs-a ) . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
27,
41
]
} | {
"id": "C0038091",
"name": "slow reacting",
"pos": [
172,
185
]
} |
in contrast , when mmc alone was administered , putrescine and spermidine levels in the tumor did not differ from those in control mice . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
48,
58
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
74,
80
]
} |
we recorded ventricular activation sequence during ventricular tachycardia in 76 patients who underwent surgical therapy of refractory ventricular tachycardia . | NA | {
"id": "C0042514",
"name": "ventricular",
"pos": [
12,
23
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
147,
158
]
} |
lactate levels ( +30 % ) as well as noradrenaline and adrenaline responses ( +60 % -90 % ) were higher in the cumulative experiment ( test 1 ) at work loads corresponding to 70 % -80 % of the oxygen uptake capacity as compared to the noncumulative testing procedure ( test 2 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
54,
64
]
} |
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