text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
bronchoalveolar lavage and biopsies were performed in 19 patients presenting severe , strictly isolated uveitis ( 5 cases of anterior uveitis , 3 cases of posterior uveitis and 11 cases of panuveitis ) . | NA | {
"id": "C0042165",
"name": "anterior uveitis",
"pos": [
125,
141
]
} | {
"id": "C0030343",
"name": "panuveitis",
"pos": [
189,
199
]
} |
bronchoalveolar lavage and biopsies were performed in 19 patients presenting severe , strictly isolated uveitis ( 5 cases of anterior uveitis , 3 cases of posterior uveitis and 11 cases of panuveitis ) . | NA | {
"id": "C0042167",
"name": "posterior uveitis",
"pos": [
155,
172
]
} | {
"id": "C0030343",
"name": "panuveitis",
"pos": [
189,
199
]
} |
they indicate that a change in outer segment glycoconjugates may accompany the shedding and phagocytosis events , as previously suggested , but this change does not necessarily involve the addition of saccharides to outer segment glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
45,
60
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
230,
243
]
} |
granular to diffuse reaction product was noted in many lung cells in frozen sections for lm , including alveolar and tissue macrophages , fibroblasts , chondrocytes , bronchial and bronchiolar epithelial cells and mast cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
138,
149
]
} |
granular to diffuse reaction product was noted in many lung cells in frozen sections for lm , including alveolar and tissue macrophages , fibroblasts , chondrocytes , bronchial and bronchiolar epithelial cells and mast cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
152,
164
]
} |
in proliferative assays , with a panel of x-irradiated allogeneic stimulator cells , a-7 was found to proliferate in response to dr3-bearing cells , whereas a-57 responds to dr2-positive stimulators . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
55,
65
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} |
this autoantibody is secreted by b lymphocytes upon stimulation by polyclonal activators and is identified by its potent inhibition of b cell growth induced by these agents ( endotoxin , fc fragment of human gamma-globulin , mycoplasma bovirhinis , and anti-mouse ig ) . | NA | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
208,
222
]
} | {
"id": "C0021027",
"name": "ig",
"pos": [
264,
266
]
} |
supernatants from coxiella-stimulated immune t cells and from the suppressor subset ( okt8+-enriched ) of those t cells , but not unstimulated immune cells , induced augmented pge2 production by unrelated nonimmune pbmc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
47,
52
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
215,
219
]
} |
we propose that some anti-dna auto-antibodies and anti-bacterial antibodies evolve from a restricted group of antibodies with high avidity for the phosphodiester groups that occur in dna and bacterial cells walls . | NA | {
"id": "C0003244",
"name": "anti-bacterial antibodies",
"pos": [
50,
75
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
110,
120
]
} |
because pge2 is known to increase the intracellular concentration of 3',5 ' cyclic adenosine monophosphate ( camp ) , we investigated the effect of another adenylate cyclase activator , i.e. , isoproterenol , as well as the effect of extracellular administration of the camp derivative dibutyryl camp ( dbcamp ) on il 2 production , tac antigen expression , and transferrin receptor expression . | NA | {
"id": "C0001455",
"name": "camp",
"pos": [
109,
113
]
} | {
"id": "C0012054",
"name": "camp",
"pos": [
305,
309
]
} |
active supernatants were devoid of antiviral ( interferon ; ifn ) or interleukin 2 ( il 2 ) activity , and ifn-beta , ifn-gamma , il 2 , and interleukin 1 were unable to activate staphylococcidal activity , suggesting that the lgl macrophage activating factor was distinguishable from these cytokines . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
47,
57
]
} | {
"id": "C0079189",
"name": "cytokines",
"pos": [
291,
300
]
} |
differences were observed in the reactivities of several dextrans considered previously to be structurally similar , and a newly proposed structural model of dextran b1299s was assessed . | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
57,
65
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
158,
165
]
} |
the 2e9 monoclonal antibody was found to share idiotypic determinants with several other independently-derived mu , kappa and gamma 1 , kappa anti-phthalate monoclonal antibodies and with a significant proportion of conventional anti-phthalate antibodies derived from all of the balb/c mice immunized with phthalate-keyhole limpet hemocyanin . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
8,
27
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
244,
254
]
} |
of interest in this comparison is that both hfpa and hfpb are amino terminal peptides on the a and b chain of fibrinogen , respectively , and are readily cleaved by thrombin during fibrin formation and by other trypsin-like enzymes , leaving a carboxyl terminal arg . | NA | {
"id": "C0016022",
"name": "hfpa",
"pos": [
44,
48
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
181,
187
]
} |
of interest in this comparison is that both hfpa and hfpb are amino terminal peptides on the a and b chain of fibrinogen , respectively , and are readily cleaved by thrombin during fibrin formation and by other trypsin-like enzymes , leaving a carboxyl terminal arg . | NA | {
"id": "C0016023",
"name": "hfpb",
"pos": [
53,
57
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
181,
187
]
} |
to study the mechanism underlying the complement-induced prostanoid synthesis , we examined whether c5b-9 affected the enzyme acyl-coa : lysolecithin acyltransferase ( e.c.2.3.1.2.3 ) that catalyzes the reinsertion of liberated arachidonic acid , the precursor molecule of the prostanoids . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
38,
48
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
100,
105
]
} |
the potency of various ligands to compete for 125i-icyp binding sites followed the order : propranolol greater than isoproterenol greater than epinephrine greater than norepinephrine with apparent kd of 2.0 x 10 ( -9 ) , 3.9 x 10 ( -7 ) , 1.0 x 10 ( -5 ) , and 2.5 x 10 ( -5 ) m , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
143,
154
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
168,
182
]
} |
in the present experiments , a23187 caused human eosinophils to release a granule protein , eosinophil-derived neurotoxin ( edn ) and a membrane-associated protein , charcot-leyden crystal ( clc ) protein in a calcium and a concentration-dependent manner . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
82,
89
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
136,
144
]
} |
the adenosine analogue 5 ' n-ethylcarboxamidoadenosine ( neca ) was a more potent inhibitor of superoxide anion generation than either n6-phenylisopropyladenosine ( pia ) or adenosine , an order of potency consistent with that previously demonstrated for adenosine a2 receptors . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
138,
162
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
255,
264
]
} |
neca , 2-chloroadenosine , adenosine , and pia inhibited binding of [ 3h ] -neca with a rank order similar to that for inhibition of superoxide anion generation ( neca = 2-chloroadenosine greater than adenosine greater than pia ) . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
0,
4
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
201,
210
]
} |
neca , 2-chloroadenosine , adenosine , and pia inhibited binding of [ 3h ] -neca with a rank order similar to that for inhibition of superoxide anion generation ( neca = 2-chloroadenosine greater than adenosine greater than pia ) . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
7,
24
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
201,
210
]
} |
neca , 2-chloroadenosine , adenosine , and pia inhibited binding of [ 3h ] -neca with a rank order similar to that for inhibition of superoxide anion generation ( neca = 2-chloroadenosine greater than adenosine greater than pia ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
15,
24
]
} | {
"id": "C0031484",
"name": "pia",
"pos": [
224,
227
]
} |
unique patterns of circulatory clearance , organ distribution , metabolism , and excretion were observed for each of the four preparations . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
64,
74
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
81,
90
]
} |
attempts will now be made to sequence the amino acid determinants of the 185k-sa , so as to define the epitopes responsible for the two major regulating functions elicited by this antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
103,
111
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
180,
187
]
} |
the serologic response was directed against a highly restricted cell surface antigen , closely related to or identical with the unique transplantation antigen characteristic for this tumor . | NA | {
"id": "C0003339",
"name": "cell surface",
"pos": [
64,
76
]
} | {
"id": "C0019628",
"name": "transplantation antigen",
"pos": [
135,
158
]
} |
although it has been suggested that human monoclonal antibodies would obviate an immune response , our work implies that such antibodies might still induce anti-idiotype antibodies if multiple infusions are administered . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
42,
63
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
170,
180
]
} |
six of the clones were subsequently shown to lyse all tested hla-b7-positive b and t lymphoid cell lines , peripheral blood lymphocytes , and a murine l cell that expressed hla-b7 as a consequence of dna-mediated gene transfer . | NA | {
"id": "C0019737",
"name": "hla",
"pos": [
61,
64
]
} | {
"id": "C0019744",
"name": "hla-b7",
"pos": [
173,
179
]
} |
our approach was based on the notion that low affinity interactions between nominal antigen and t cell antigen receptors might be detected by using a highly multivalent form of the antigen in which a large number of identical , appropriately spaced epitopes are attached to a polymer backbone . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
84,
91
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
249,
257
]
} |
the results indicate that antigen-primed fcr+ t cells produced ige-suppressive factors and igg-suppressive factors on antigenic stimulation . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
26,
33
]
} | {
"id": "C0003316",
"name": "factors",
"pos": [
107,
114
]
} |
regulation of lymphokine production by arginine vasopressin and oxytocin : modulation of lymphocyte function by neurohypophyseal hormones . | NA | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
64,
72
]
} | {
"id": "C0032017",
"name": "neurohypophyseal hormones",
"pos": [
112,
137
]
} |
examples would include thymosin alpha 1 and beta 4 , lymphocyte-derived acth , tsh , and beta-endorphin , interleukin 1 , interferon as well as certain other lymphokines and cytokines . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
122,
132
]
} | {
"id": "C0079189",
"name": "cytokines",
"pos": [
174,
183
]
} |
co 29.11 bound to purified sialylated lewis a ( lea ) antigen but to a different epitope and with a higher binding affinity than the mab ca 19-9 . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
54,
61
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
81,
88
]
} |
with this method , different h-d antigen-active molecules were compared for heterophile h-d antigen potency with reasonable sensitivity detecting about 0.3 ng of cold glycoprotein . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
33,
40
]
} | {
"id": "C0003333",
"name": "heterophile",
"pos": [
76,
87
]
} |
two groups of cells were studied : ( a ) thymocytes , tonsil cells and peripheral blood mononuclear cells ( pbmc ) , ( b ) ada-positive and ada-deficient cell lines . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
14,
19
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
71,
105
]
} |
a simple ' 1-step ' competitive erythro-immunoassay for human chorionic gonadotropin ( hcg ) employing v-shaped well microtitration plates coated with monoclonal anti-beta-hcg antibody has been described . | NA | {
"id": "C0018062",
"name": "human chorionic",
"pos": [
56,
71
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
167,
175
]
} |
interleukin-2 ( il-2 ) , colony stimulating factor ( csf ) and macrophage activating factor ( maf ) are lymphokines with distinct biologic activities and are secreted by the el-4 cell line . | NA | {
"id": "C0079786",
"name": "macrophage activating factor",
"pos": [
63,
91
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
104,
115
]
} |
in mice , both death and skin disease can be prevented by the use of an antiserum containing antibodies to a cell surface glycolipid , asialo gm1 ( asgm1 ) . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
72,
81
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
93,
103
]
} |
single-stranded dna antibodies are also commonly detected in patients with systemic lupus erythematosus ( sle ) but recent evidence indicates that approximately 25 % of patients with benign , cutaneous ( discoid ) lupus also possess single-stranded dna igm autoantibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
20,
30
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
257,
271
]
} |
human hypersensitivity angiitis is an immune complex disease in which patients present with palpable purpuric lesions of the skin and may often have multiple organ involvement . | NA | {
"id": "C0151436",
"name": "hypersensitivity angiitis",
"pos": [
6,
31
]
} | {
"id": "C0020951",
"name": "immune complex disease",
"pos": [
38,
60
]
} |
the experimental linkage of uv radiation to autoantibody binding to keratinocytes and the demonstration of mononuclear cell-mediated adcc causing keratinocyte lysis support our hypothesis that the keratinocyte damage and mononuclear cell infiltrate seen histologically in cutaneous le are part of an adcc process . | NA | {
"id": "C0007634",
"name": "adcc",
"pos": [
133,
137
]
} | {
"id": "C0022567",
"name": "damage",
"pos": [
210,
216
]
} |
in addition to its effect on inflammatory and immune events , etaf has growth promoting effects on keratinocytes and fibroblasts . | NA | {
"id": "C0007634",
"name": "etaf",
"pos": [
62,
66
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
117,
128
]
} |
autoimmune diseases include entities of varied clinical expression such as juvenile onset diabetes mellitus , rheumatoid arthritis , multiple sclerosis , and thyroiditis . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
0,
19
]
} | {
"id": "C0011854",
"name": "juvenile onset diabetes mellitus",
"pos": [
75,
107
]
} |
analysis of symptoms of infection , the initial laboratory evaluation , the initial impression of the severity of illness , the clinical course , and the eventual outcome showed no differences between children with bacteremia and those with acute gastroenteritis , nor did a comparison between older children ( one year of age or older ) and younger children , with either bacteremia or acute gastroenteritis , show appreciable differences . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
201,
209
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
294,
308
]
} |
after hypotonic treatment of the colony cells and their attachment to the slides , the cells were fixed by a three-step procedure as follows : addition of a 30 % fixative ( 3:1 methanol : acetic acid ) diluted with the hypotonic solution , addition of 20 % ethanol , and subsequent immersion of the slides in a 100 % fixative . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
177,
185
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
257,
264
]
} |
on the cdna level , the dominating species was identical with the type of ifn-alpha a or ifn-alpha 2 ; | NA | {
"id": "C0002199",
"name": "ifn",
"pos": [
74,
77
]
} | {
"id": "C0021734",
"name": "ifn-alpha 2",
"pos": [
89,
100
]
} |
similarly , rough or incomplete lipopolysaccharide subunits from mutant bacterial strains , or lipid a prepared by mild acid hydrolysis of whole endotoxin , are also stimulatory . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
32,
50
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
95,
102
]
} |
similarly , rough or incomplete lipopolysaccharide subunits from mutant bacterial strains , or lipid a prepared by mild acid hydrolysis of whole endotoxin , are also stimulatory . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
32,
50
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
145,
154
]
} |
the procoagulant , tissue factor , is synthesized by endothelial cells after stimulation mediated by a moiety contained within the lipid a region of lipopolysaccharide . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
131,
138
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
149,
167
]
} |
gm 2000 fhc fibroblasts revealed ldl receptors with an apparent molecular weight of approximately 140,000 , the same as in normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
12,
23
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
123,
135
]
} |
recombination and crossover of serum fractions of patients and controls separated by ultracentrifugation revealed that the defect in cholesterol transfer of the patients was in the d greater than 1.063 gm/ml fraction ( containing hdl and other serum proteins ) , which not only contained less hdl cholesterol , but was also qualitatively inferior as donor for cholesterol transfer . | NA | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
293,
308
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
360,
371
]
} |
the cholesteryl ester content of plasma low density lipoproteins ( ldl ) in monkeys has previously been shown to be related to the rate of hepatic cholesterol secretion and cholesteryl ester content of newly secreted lipoproteins in the isolated perfused liver . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
147,
158
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
173,
190
]
} |
sf greater than 400 lipoprotein and vldl triglyceride content decreased but remained a major core lipid . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
20,
31
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
98,
103
]
} |
more specifically , at positions +32 , +33 , +37 , +39 , the dna sequence predicts glu , ser , gln , ala , respectively , while the previously reported sequence specifies ser , gln , ala , gln , respectively . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
83,
86
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
189,
192
]
} |
the anion current-voltage ( i-v ) relationship of warm-acclimated fibres exhibited constant-field rectification , while the i-v relationship of cold-acclimated fibres was linear . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
4,
9
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
172,
173
]
} |
by the use of an m6 monoclonal antibody , which crossreacts with 20 different m protein types , and antibodies to the n-acetyl glucosamine determinant of the cell wall , we have been able to identify the m protein molecules released from the streptococcal cell wall with muralytic enzymes , particularly group c phage-associated lysin . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
20,
39
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
100,
110
]
} |
( b ) a t hybrid ( nimp-th1 ) produces edf but no il-2 , il-3 , interferon , or colony-stimulating factor . | NA | {
"id": "C0021757",
"name": "il-3",
"pos": [
57,
61
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
80,
105
]
} |
a theoretical treatment for the estimation of blood alcohol concentration arising from inhalation of ethanol vapour . | NA | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
46,
73
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
101,
108
]
} |
this oxication causes enzyme inhibition and unlike hemoglobin , which has the methemoglobin reduction system , these enzymes remain in the oxidized state , resulting in the clinical signs and conditions described . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
51,
61
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
78,
91
]
} |
there was no carcinoid syndrome nor the other clinical symptoms after the operation and various postoperative examination could not reveal a primary site of the carcinoid tumor . | NA | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
13,
31
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
161,
170
]
} |
therefore , no binding of aprindine to albumin molecules has been demonstrated and it is concluded that the entire binding of aprindine in serum as well as in 98 % hsa solutions may be due to the presence of acid protein molecules . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
39,
46
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
213,
220
]
} |
the accumulated polyamines were not removed by washing with spermine or spermidine solutions , but they were released by treatment of the cells with butanol . | NA | {
"id": "C0037874",
"name": "spermine",
"pos": [
60,
68
]
} | {
"id": "C0037871",
"name": "solutions",
"pos": [
83,
92
]
} |
it should be emphasized that elevated plasma triglycerides and cholesterol are due to underlying defects in lipoprotein metabolism and should not be confused with primary hyperlipidemia . | NA | {
"id": "C0020557",
"name": "elevated",
"pos": [
29,
37
]
} | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
171,
185
]
} |
as senile plaque numbers increased in non-demented and demented old people , activities of choline acetyltransferase and acetylcholinesterase decreased , butyrylcholinesterase increased and muscarinic receptor binding remained unchanged . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
121,
141
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
154,
175
]
} |
light and electron microscopy showed that these granules had characteristics of those seen in several other types of mucopolysaccharidoses , including morquio 's syndrome , which are of a different structure than those of other types of mucopolysaccharidosis . | NA | {
"id": "C0026707",
"name": "morquio 's syndrome",
"pos": [
151,
170
]
} | {
"id": "C0026703",
"name": "mucopolysaccharidosis",
"pos": [
237,
258
]
} |
studies revealed elevated urinary 17-ketosteroid levels ( 15.8 , 18.8 mg/24 hours ) and increased serum levels of 17-oh-progesterone ( 2,756 , 1,121 ng/dl ) , 21-desoxycortisol ( 1,882 , 1,090 ng/dl ) , progesterone ( 300 , 346 ng/dl ) , dehydroepiandrosterone ( dha ) ( 1,600 , 1,700 ng/dl ) , and androstenedione ( 402 , 366 ng/dl ) and testosterone ( 100 , 104 ng/dl ) , together with a slight increase in serum 11-desoxycortisol ( 1,180 , 1,560 ng/dl ) . | NA | {
"id": "C0000167",
"name": "17-ketosteroid",
"pos": [
34,
48
]
} | {
"id": "C0002860",
"name": "androstenedione",
"pos": [
299,
314
]
} |
studies revealed elevated urinary 17-ketosteroid levels ( 15.8 , 18.8 mg/24 hours ) and increased serum levels of 17-oh-progesterone ( 2,756 , 1,121 ng/dl ) , 21-desoxycortisol ( 1,882 , 1,090 ng/dl ) , progesterone ( 300 , 346 ng/dl ) , dehydroepiandrosterone ( dha ) ( 1,600 , 1,700 ng/dl ) , and androstenedione ( 402 , 366 ng/dl ) and testosterone ( 100 , 104 ng/dl ) , together with a slight increase in serum 11-desoxycortisol ( 1,180 , 1,560 ng/dl ) . | NA | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
114,
132
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
203,
215
]
} |
a group of 100 women desiring oc received one of the following four formulations on a randomized basis : ( 1 ) mestranol 50 micrograms and norethindrone 1 mg , , ( 2 ) ethinyl estradiol 50 micrograms and norethindrone 1 mg , ( 3 ) ethinyl estradiol 35 micrograms and norethindrone 1 mg , and ( 4 ) ethinyl estradiol 30 micrograms and levonorgestrel 150 mg . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
111,
120
]
} | {
"id": "C0015011",
"name": "ethinyl estradiol",
"pos": [
298,
315
]
} |
an increase in the number of hepatocytic microfilaments with an increase in the apparent density of the filamentous network and in the thickness of bundles of filaments was evident in the vicinity of the bile canaliculi , in the pericanalicular ectoplasm , and in the surrounding cytoplasm in all types of cholestasis but more so in intrahepatic cholestasis . | NA | {
"id": "C0008370",
"name": "cholestasis",
"pos": [
306,
317
]
} | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
333,
357
]
} |
group b ( 6 dogs ) were given adr and weekly doses of vitamin e ( 17 mg/kg body weight ) as alpha-tocopherol acetate ; | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
54,
63
]
} | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
92,
116
]
} |
these results provide further evidence that the synthesis of angiotensinogen may be increased by angiotensin ii , but indicate that the circulating level of angiotensin ii in sodium-deficient animals is not sufficiently high to produce this response . | NA | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
61,
76
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
157,
168
]
} |
these results provide further evidence that the synthesis of angiotensinogen may be increased by angiotensin ii , but indicate that the circulating level of angiotensin ii in sodium-deficient animals is not sufficiently high to produce this response . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
97,
111
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
157,
168
]
} |
we have developed a theoretical model of this charge-selectivity based on the following principal assumptions : a ) all ions ( tracer macromolecule and univalent cations and anions ) obey a modified nernst-planck flux expression , including terms for convection and size-selective retardation ; | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
105,
109
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
162,
169
]
} |
we have developed a theoretical model of this charge-selectivity based on the following principal assumptions : a ) all ions ( tracer macromolecule and univalent cations and anions ) obey a modified nernst-planck flux expression , including terms for convection and size-selective retardation ; | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
105,
109
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
174,
180
]
} |
the cellular contents of nucleic acids and proteins ( in pg/cell ) were : dna 22.5 +/- 1.1 ; | NA | {
"id": "C0028606",
"name": "nucleic",
"pos": [
25,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
74,
77
]
} |
the possibility that prostaglandins ( pg ) contribute to skeletal muscle exercise hyperemia was tested by blocking pg synthesis with indomethacin and by measuring muscle prostaglandin e ( pge ) release . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
21,
35
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
170,
185
]
} |
distributions of t-cell subpopulations before and after in vitro allergen stimulation were studied in 57 house dust sensitive asthmatic children and 23 healthy persons . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
65,
73
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
105,
115
]
} |
at the cellular level , development proceeds in a series of stages in which precursor cells are first restricted in their developmental potential ( determination ) and subsequently express their genetic information as specific tissues ( differentiation ) . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
7,
15
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
76,
91
]
} |
a novel approach involves the inhibition of differentiation by virus transformation of the precursor cells in the chick primary mesenchyme , the transformed cells are cloned , grown to large numbers , and then analyzed biochemically . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
91,
106
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
157,
162
]
} |
when hyperplasia is the underlying pathological condition subtotal parathyroidectomy , or resection of 3 1/2 glands , is indicated . | NA | {
"id": "C0020507",
"name": "hyperplasia",
"pos": [
5,
16
]
} | {
"id": "C0030660",
"name": "pathological condition",
"pos": [
35,
57
]
} |
a method is presented for measuring simultaneously five anti-convulsants ( primidone , ethosuximide , phenobarbital , carbamazepine and diphenylhydantoin ) in serum and plasma by high-performance liquid chromatography ( hplc ) using alphenal ( 5 - allyl - 5 - phenyl - barbituric acid ) as the internal standard . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
75,
84
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
102,
115
]
} |
the lower limits of detection for each drug is 200 ng per ml for primidone , 1000 ng per ml for ethosuximide , 200 ng per ml for phenobarbital , 100 ng per ml for carbamazepine and 200 ng per ml for diphenylhydantoin . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
65,
74
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
129,
142
]
} |
correlation of results for 187 specimens by enzyme-immunoassay ( emit ) was 0.981 for primidone , 0.827 for ethosuximide , 0.975 for phenobarbital , 0.889 for carbamazepine and 0.990 for diphenylhydantoin . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
86,
95
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
133,
146
]
} |
segregation of human pgm3 has been analyzed in somatic cell hybrids between mouse a9 cells and human fibroblasts carrying a reciprocal translocation : 46 , xx , t ( 6 ; 7 ) ( q12 ; p14 ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
85,
90
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
101,
112
]
} |
changes in the activity and isozyme patterns of glycolytic enzymes during stimulation of normal human lymphocytes with phytohaemagglutinin . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
28,
35
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
59,
66
]
} |
starch-gel electrophoresis was used to examine the isozyme patterns of the enzymes before and after exposure of the lymphocytes to pha . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
51,
58
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
75,
82
]
} |
four of the enzymes , aldolase , triosephosphate isomerase , enolase and lactate dehydrogenase , showed different isozyme patterns in stimulated cells from those seen in uncultured or unstimulated cells . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
12,
19
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
114,
121
]
} |
the frequency of all types of chromosome abnormalities detected was similar to that found in previous newborn surveys , which were carried out on different socio-economic structure , but the incidence of aneuploid chromosome abnormalities was comparable in the two localities . | NA | {
"id": "C0008626",
"name": "of",
"pos": [
14,
16
]
} | {
"id": "C0002938",
"name": "aneuploid",
"pos": [
204,
213
]
} |
triggering factors , seizure patterns , and ictal electroencephalograms were the same as in startle epilepsy occurring in children with cerebral palsy but differed in that there was no clinical or radiological evidence of a focal brain lesion in the vicinity of the motor supplementary cortex . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
21,
28
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
100,
108
]
} |
additional studies revealed that changes in leg vascular resistance were markedly diminished in the injured leg following hemorrhage , spinal anesthesia , or intravenous infusion of epinephrine or norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
182,
193
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
197,
211
]
} |
sixty-six patients admitted to the coronary care unit within 12 hours of the onset of symptoms of acute myocardial infarction ( ami ) were subjected to blood sampling at one- to two-hour intervals for analysis of creatine phosphokinase ( cpk ) and lactic dehydrogenase ( ldh ) enzymes and isoenzymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
277,
284
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
289,
299
]
} |
psychometric tests were administered to 36 alcoholic patients with cirrhosis without overt portal systemic encephalopathy and to 32 alcoholics without liver diseases . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
67,
76
]
} | {
"id": "C0023895",
"name": "liver",
"pos": [
151,
156
]
} |
anatomical and functional renal medullary abnormalities are common in patients with sickle cell disease ( hbss ) and sickle cell trait ( hbas ) . | NA | {
"id": "C0002895",
"name": "sickle cell disease",
"pos": [
84,
103
]
} | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
117,
134
]
} |
these data suggest that a reciprocal relationship exists between plasma concentration of t3 and both norepinephrine and epinephrine in untreated burn patients and that treatment with the metabolically active hormone , triiodothyronine , does not alter the level of hypermetabolism accompanying thermal injury . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
indications for splenectomy include hypersplenism , incidental to other abdominal procedures , trauma , hodgkin 's staging , and other splenic disease . | NA | {
"id": "C0020532",
"name": "hypersplenism",
"pos": [
36,
49
]
} | {
"id": "C0037997",
"name": "splenic disease",
"pos": [
135,
150
]
} |
these data indicate the participation of the immunopathologic reactions in skin injury produced by psoriasis and their implication in the maintenance of the pathologic process in further disease progress . | NA | {
"id": "C0030660",
"name": "pathologic process",
"pos": [
157,
175
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
187,
194
]
} |
congenital cavitary anomalies of the optic disc ( optic pit and coloboma ) are uncommon and frequently go unrecognized . | NA | {
"id": "C0015393",
"name": "congenital",
"pos": [
0,
10
]
} | {
"id": "C0009363",
"name": "coloboma",
"pos": [
64,
72
]
} |
in an experimental model of pseudomonas keratitis produced by a gentamicin sulfate-resistant , tobramycin sulfate-sensitive strain of p aeruginosa , the results of two treatment regimens- ( 1 ) with gentamicin and tobramycin alone and ( 2 ) with gentamicin , tobramycin , and a steroid-were evaluated . | NA | {
"id": "C0546866",
"name": "gentamicin",
"pos": [
64,
74
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
246,
256
]
} |
in an experimental model of pseudomonas keratitis produced by a gentamicin sulfate-resistant , tobramycin sulfate-sensitive strain of p aeruginosa , the results of two treatment regimens- ( 1 ) with gentamicin and tobramycin alone and ( 2 ) with gentamicin , tobramycin , and a steroid-were evaluated . | NA | {
"id": "C0027519",
"name": "sulfate",
"pos": [
75,
82
]
} | {
"id": "C0040341",
"name": "tobramycin",
"pos": [
259,
269
]
} |
florid invasion of the leptomeninges ( arachnoidal gliomatosis ) exhibited by many optic nerve gliomas in neurofibromatosis suggests that they are true neoplasms rather than hamartomas , but their frequent location in the distal anterior visual pathway often confers a good clinical prognosis . | NA | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
152,
161
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
174,
184
]
} |
an extensive study of the incidence of urinary stone formation has been made , with particular emphasis on idiopathic bladder stones in children , and the work carried out up to the present has been reviewed . | NA | {
"id": "C0042018",
"name": "urinary stone",
"pos": [
39,
52
]
} | {
"id": "C0005683",
"name": "bladder stones",
"pos": [
118,
132
]
} |
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