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the stimulatory effect of salts ( nadp+ ) was nonspecific , regardless of the anion or cation , whereas the degree of nad+-linked inhibition decreased in the order to i- greater than br- greater than cl- greater than f- .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 78, 83 ] }
{ "id": "C0021966", "name": "i", "pos": [ 167, 168 ] }
the stimulatory effect of salts ( nadp+ ) was nonspecific , regardless of the anion or cation , whereas the degree of nad+-linked inhibition decreased in the order to i- greater than br- greater than cl- greater than f- .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 78, 83 ] }
{ "id": "C0016327", "name": "f", "pos": [ 217, 218 ] }
the pattern of proteins synthesized by chicken embryo fibroblasts changes dramatically after these cells are incubated at 45 degrees c for a few hours .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 54, 65 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 99, 104 ] }
transient and steady state kinetics of the interaction of liver plasma membrane adenylyl cyclase with gtp and the gtp analogues guanyl-5'-yl imidodiphosphate ( gmp-p ( nh ) p ) , guanyl-5'-yl diphosphonate ( gmp-p ( ch2 ) p ) , and guanosine 5'- ( 3-o-thio ) triphosphate ( gtp gamma s ) was studied before and after treatment of membranes with preactivated cholera toxin .
NA
{ "id": "C0018353", "name": "gtp", "pos": [ 102, 105 ] }
{ "id": "C0018366", "name": "guanyl-5", "pos": [ 179, 187 ] }
transient and steady state kinetics of the interaction of liver plasma membrane adenylyl cyclase with gtp and the gtp analogues guanyl-5'-yl imidodiphosphate ( gmp-p ( nh ) p ) , guanyl-5'-yl diphosphonate ( gmp-p ( ch2 ) p ) , and guanosine 5'- ( 3-o-thio ) triphosphate ( gtp gamma s ) was studied before and after treatment of membranes with preactivated cholera toxin .
NA
{ "id": "C0018353", "name": "gtp", "pos": [ 102, 105 ] }
{ "id": "C0079469", "name": "gtp gamma s", "pos": [ 274, 285 ] }
( a ) in control experiments , gtp stimulated the enzyme partially and without a noticeable lag , while gtp analogues stimulated to varying degrees ( gtp gamma s approximately gmp-p ( nh ) p greater than gmp-p ( ch2 ) p greater than or equal to gtp ) and with lag periods that varied with the nucleotide ( gmp-p ( nh ) p approximately gmp-p ( ch2 ) p greater than gtp gamma s ) .
NA
{ "id": "C0018353", "name": "gtp", "pos": [ 31, 34 ] }
{ "id": "C0079469", "name": "gtp gamma s", "pos": [ 364, 375 ] }
this fraction of dna which binds actinomycin d with highest affinity did not contain any rdna as evidenced by hybridization with [ 32p ] rrna .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 17, 20 ] }
{ "id": "C0012933", "name": "rdna", "pos": [ 89, 93 ] }
under these conditions , transport is inhibited by reserpine , norepinephrine , and epinephrine , but not by imipramine , and requires either atp or an artificially imposed ph gradient ( interior acidic ) across the organelle membrane .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 63, 77 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 84, 95 ] }
they show differences in cellular and extracellular substrate properties of the polyamines and indicate cross-linking through these amines in the extracellular system , but provide no evidence for such cross-linking in the cells .
NA
{ "id": "C0032433", "name": "polyamines", "pos": [ 80, 90 ] }
{ "id": "C0002508", "name": "amines", "pos": [ 132, 138 ] }
rna labeled in vitro at the 5 ' end with [ gamma-32p ] atp was digested with rnase t1 , rnase a , and s1 nuclease .
NA
{ "id": "C0018364", "name": "rnase t1", "pos": [ 77, 85 ] }
{ "id": "C0014241", "name": "rnase", "pos": [ 88, 93 ] }
the thrombogenicity of five suture materials -- polypropylene ( prolene ) , polyester ( mersilene ) , polyglactin 910 ( vicryl ) , nylon ( tthilon ) , and silk -- was examined in vivo by scanning electron microscopy .
NA
{ "id": "C0032474", "name": "polyester", "pos": [ 76, 85 ] }
{ "id": "C0032495", "name": "polyglactin 910", "pos": [ 102, 117 ] }
scintigraphy versus radiography in the early diagnosis of experimental bone necrosis , with special reference to caisson disease of bone .
NA
{ "id": "C0029445", "name": "of", "pos": [ 55, 57 ] }
{ "id": "C0005940", "name": "disease of bone", "pos": [ 121, 136 ] }
renal vein varices are abnormalities known to be responsible for intermittent hematuria , but may be found in patients with no history of bleeding .
NA
{ "id": "C0018965", "name": "hematuria", "pos": [ 78, 87 ] }
{ "id": "C0019080", "name": "bleeding", "pos": [ 138, 146 ] }
when sperm nuclei were treated with the esterase inhibitor nitrophenyl-p-guanidino benzoate ( npgb ) to inhibit the nuclear-associated proteolytic activity and then incubated with one of several exogenous proteinases in addition to dtt and triton x-100 , characteristic peptide banding patterns were seen for each exogenous proteinase employed .
NA
{ "id": "C0030940", "name": "proteinases", "pos": [ 205, 216 ] }
{ "id": "C0030946", "name": "proteinase", "pos": [ 324, 334 ] }
121:111-120 ) that treatment of human fibroblasts , planted at a density of 2x10 ( 3 ) cells/cm ( 2 ) , with purified human fibroblasts interferon ( 640 u/ml ) for 3 d at 37 degrees c decreases the overall rate of cell proliferation to 35-40 percent of the control value .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 38, 49 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 87, 92 ] }
the number of actin fibers of all sizes was tripled in the treated fibroblasts on a per cell basis and , calculated per unit surface area of the cells , the number was increased 82 percent .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 67, 78 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 145, 150 ] }
of the cells examined to date , epithelial cells ( both normal and tumour ) do not show infiltrative behaviour , while both normal and virally transformed fibroblasts , as well as tumour cells of non-epithelial origin ( e.g . melanoma ) , do infiltrate into the collagen gel matrix , at rates which vary considerably according to cell type .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 155, 166 ] }
{ "id": "C0007634", "name": "cell type", "pos": [ 330, 339 ] }
the morphology of the cytoskeleton of normal 3t3 fibroblasts was studied in the electron microscope on embedded and sectioned cells as well as on critical-point-dried whole mounts .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 49, 60 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 126, 131 ] }
a quantitative high-performance liquid chromatographic method , using a polystyrene-divinyl benzene ( hitachi no . 3010 gel ) column and aqueous methanol as the mobile phase , was employed for the determination of aminopyrine and its related compounds , 4-acetyl-aminoantipyrine , 4-aminoantipyrine and 4-monomethylaminoantipyrine .
NA
{ "id": "C0002586", "name": "aminopyrine", "pos": [ 214, 225 ] }
{ "id": "C0002696", "name": "4-aminoantipyrine", "pos": [ 281, 298 ] }
uring calcium and camp excretion were measured under basal conditions and after oral administration of calcium phosphate .
NA
{ "id": "C0006675", "name": "calcium", "pos": [ 6, 13 ] }
{ "id": "C0006711", "name": "calcium", "pos": [ 103, 110 ] }
the oxidation of methionine by the combination of h ( 2 ) o ( 2 ) and granular fractions was inhibited by ( 1 ) o ( 2 ) quenchers and mpo inhibitors , but it was stimulated by deuterium oxide .
NA
{ "id": "C0011744", "name": "h ( 2", "pos": [ 50, 55 ] }
{ "id": "C0011745", "name": "deuterium oxide", "pos": [ 176, 191 ] }
preincubation of pbm with either pen ( 100 mug/ml ) or cuso ( 4 ) ( 2 mug/ml ) did not alter the subsequent capacity of the cells to generate isc in response to pwm or spa .
NA
{ "id": "C1321301", "name": "pbm", "pos": [ 17, 20 ] }
{ "id": "C0007634", "name": "the", "pos": [ 120, 123 ] }
experiments in which pbm were separated into adherent and nonadherent populations indicated that pen and cuso ( 4 ) preincubation inhibited the responsiveness of the nonadherent cells but did not alter the accessory cell function of monocytes .
NA
{ "id": "C1321301", "name": "pbm", "pos": [ 21, 24 ] }
{ "id": "C0007634", "name": "the", "pos": [ 202, 205 ] }
glycine is taken up from arterial plasma , while similar amounts of this amino acid are released by way of blood cells .
NA
{ "id": "C0017890", "name": "glycine", "pos": [ 0, 7 ] }
{ "id": "C0002520", "name": "amino acid", "pos": [ 73, 83 ] }
52 sera were positive for antibody to viral capsid antigen , and antibody to rheumatoid arthritis nuclear antigen was present in 26 ( 50 % ) of these .
NA
{ "id": "C0003342", "name": "viral", "pos": [ 38, 43 ] }
{ "id": "C0003320", "name": "antigen", "pos": [ 106, 113 ] }
cutaneous t cell lymphoma ( ctcl ) is a clinically and immunologically defined neoplasm which encompasses epidermotropic ( mycosis fungoides , sezary syndrome ) and nonepidermotropic variants .
NA
{ "id": "C0079773", "name": "cutaneous t cell lymphoma", "pos": [ 0, 25 ] }
{ "id": "C0036920", "name": "sezary syndrome", "pos": [ 143, 158 ] }
a comparison between candidiasis patients with and without dermatophytosis revealed no significant differences in their distribution within the various clinical syndromes of chronic mucocutaneous candidiasis nor in the immunologic responses that were tested .
NA
{ "id": "C0006840", "name": "candidiasis", "pos": [ 21, 32 ] }
{ "id": "C0006845", "name": "chronic mucocutaneous candidiasis", "pos": [ 174, 207 ] }
of the catecholamines , adrenaline causes excessive renal vasoconstriction and peripheral gangrene , noradrenaline increase myocardial work and diminishes peripheral perfusion and isoprenaline distributes blood away from the vital organs , namely : brain , kidneys , heart and mesentery .
NA
{ "id": "C0007412", "name": "catecholamines", "pos": [ 7, 21 ] }
{ "id": "C0022245", "name": "isoprenaline", "pos": [ 180, 192 ] }
of the catecholamines , adrenaline causes excessive renal vasoconstriction and peripheral gangrene , noradrenaline increase myocardial work and diminishes peripheral perfusion and isoprenaline distributes blood away from the vital organs , namely : brain , kidneys , heart and mesentery .
NA
{ "id": "C0014563", "name": "adrenaline", "pos": [ 24, 34 ] }
{ "id": "C0028351", "name": "noradrenaline", "pos": [ 101, 114 ] }
antigen binding and presentation was antigen specific and could be blocked with anti-mu antibody , but not by antibodies directed against other immunoglobulin classes .
NA
{ "id": "C0003241", "name": "antibodies", "pos": [ 110, 120 ] }
{ "id": "C0021017", "name": "immunoglobulin classes", "pos": [ 144, 166 ] }
the data suggest that , early after antigen injection , antibody is produced that can react with both the immunizing antigen and with structurally unrelated antigenic determinants .
NA
{ "id": "C0003320", "name": "antigen", "pos": [ 36, 43 ] }
{ "id": "C0003316", "name": "antigenic determinants", "pos": [ 157, 179 ] }
these findings support the hypothesis that polyclonal activation of pulmonary lymphocytes promotes immune complex-type alveolitis , possibly by facilitating interactions between humoral antibody and intra-alveolar antigen .
NA
{ "id": "C0003313", "name": "immune complex", "pos": [ 99, 113 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 186, 194 ] }
we propose that the mechanism for 5-hete- and 12-hete-induced degranulation is an alteration in the fatty acid composition of membrane phospholipids .
NA
{ "id": "C0020349", "name": "hete", "pos": [ 36, 40 ] }
{ "id": "C0044800", "name": "12-hete", "pos": [ 46, 53 ] }
the effect of epitope density on the in vitro immunogenicity of hapten-sensitized liposomal model membranes .
NA
{ "id": "C0003316", "name": "epitope", "pos": [ 14, 21 ] }
{ "id": "C0018593", "name": "hapten", "pos": [ 64, 70 ] }
these data demonstrate that am can respond in vitro to lymphokines and that maf encapsulated within liposomes is far more efficient in rendering am tumoridical than free maf .
NA
{ "id": "C0024297", "name": "lymphokines", "pos": [ 55, 66 ] }
{ "id": "C0079786", "name": "maf", "pos": [ 170, 173 ] }
the ctl response could be restored by adding normal syngeneic peritoneal cells ( pc ) or l cell fibroblasts but not by allogeneic pc or balb/c 3t3 fibroblasts .
NA
{ "id": "C0007634", "name": "normal", "pos": [ 45, 51 ] }
{ "id": "C3485979", "name": "allogeneic pc", "pos": [ 119, 132 ] }
the ctl response could be restored by adding normal syngeneic peritoneal cells ( pc ) or l cell fibroblasts but not by allogeneic pc or balb/c 3t3 fibroblasts .
NA
{ "id": "C0007634", "name": "normal", "pos": [ 45, 51 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 147, 158 ] }
by immunofluorescence , the cell responsible for the synthesis of collagen appeared to have a fibroblastic morphology .
NA
{ "id": "C0007634", "name": "cell", "pos": [ 28, 32 ] }
{ "id": "C0016030", "name": "fibroblastic", "pos": [ 94, 106 ] }
a significant increase of enzyme activity , measured in the presence of fluoride ions ( naf ) , after oestradiol treatment was found in preparations from neonatal but not from those of immature female mice ;
NA
{ "id": "C0016327", "name": "fluoride ions", "pos": [ 72, 85 ] }
{ "id": "C0037508", "name": "naf", "pos": [ 88, 91 ] }
preincubation of glucosyltransferase with the low molecular weight dextran t10 increased subsequent binding to s. mutans b13 insoluble glucan , whereas preincubation with higher molecular weight dextrans significantly inhibited the glucosyltransferase binding .
NA
{ "id": "C0011793", "name": "low molecular weight dextran", "pos": [ 46, 74 ] }
{ "id": "C0011806", "name": "dextrans", "pos": [ 195, 203 ] }
the oligomannosyl glycans of the p62 proteins formed were about two monosaccharide units larger than those of the mature virus e2 proteins .
NA
{ "id": "C0033684", "name": "proteins", "pos": [ 37, 45 ] }
{ "id": "C0042736", "name": "virus", "pos": [ 121, 126 ] }
plasma concentrations of adrenaline and noradrenaline were measured sequentially over the immediate post-operative period following clipping of an intracranial aneurysm in 11 patients .
NA
{ "id": "C0014563", "name": "adrenaline", "pos": [ 25, 35 ] }
{ "id": "C0028351", "name": "noradrenaline", "pos": [ 40, 53 ] }
those patients who developed local cerebral vasospasm showed a sustained rise in plasma catecholamines , particularly noradrenaline , whilst those patients who developed generalised cerebral vasospasm showed early peaks of very high concentrations of adrenaline and noradrenaline which preceded radiological evidence of generalized vasospam .
NA
{ "id": "C0014563", "name": "adrenaline", "pos": [ 121, 131 ] }
{ "id": "C0028351", "name": "noradrenaline", "pos": [ 266, 279 ] }
2 ) 18.6 % glucose plus 2.50 % amino acids based on human milk pattern ( s-2 ) , and 3 ) 18.6 % glucose plus 2.58 % amino acids enriched with bcaas ( s-3 ) .
NA
{ "id": "C0002520", "name": "amino acids", "pos": [ 31, 42 ] }
{ "id": "C0002521", "name": "bcaas", "pos": [ 142, 147 ] }
however , no significant differences were observed in the levels of noradrenalin , adrenalin and dopamine in any of the tissues analyzed .
NA
{ "id": "C0028351", "name": "noradrenalin", "pos": [ 68, 80 ] }
{ "id": "C0014563", "name": "adrenalin", "pos": [ 83, 92 ] }
to evaluate the efficacy of lithium carbonate in ameliorating leukopenia , 37 patients ( 3 to 26 years old , mea ( less than or equal to 1,000/mm3 ) over 40 % of the time were designated at random on the last day of 82 separate chemotherapy courses to receive lithium or no treatment .
NA
{ "id": "C0085217", "name": "lithium carbonate", "pos": [ 28, 45 ] }
{ "id": "C0023870", "name": "lithium", "pos": [ 260, 267 ] }
these findings suggest that patients observed with periorbital soft tissue defects may be at risk for the development of unilateral anisometropic refractive errors and secondary amblyopia .
NA
{ "id": "C0003081", "name": "anisometropic", "pos": [ 132, 145 ] }
{ "id": "C0034951", "name": "refractive errors", "pos": [ 146, 163 ] }
between 1940 and 1975 , 86 patients with malrotation of the intestine leading to intestinal obstruction or volvulus were treated at the university children 's hospital of zurich .
NA
{ "id": "C0021843", "name": "intestinal obstruction", "pos": [ 81, 103 ] }
{ "id": "C0042961", "name": "volvulus", "pos": [ 107, 115 ] }
after an i.v . bolus , the plasma half-life of naltrexone between 30 min and 3 hr was 55 +/- 5 min and 53 +/- 3 min for 1 and 5 mg/kg doses of naltrexone . hcl , respectively .
NA
{ "id": "C0027360", "name": "naltrexone", "pos": [ 47, 57 ] }
{ "id": "C0355800", "name": "naltrexone", "pos": [ 143, 153 ] }
structure -- activity data suggest that the presence of a carboxylic acid moiety at the 2 position affords optimal potency and that esters are preferred for good oral absorption .
NA
{ "id": "C0007066", "name": "carboxylic acid", "pos": [ 58, 73 ] }
{ "id": "C0014898", "name": "esters", "pos": [ 132, 138 ] }
the n-tosyl chloromethyl ketone analogues prepared from glycine , l-alanine , beta-alanine , l-valine , and 6- ( n-tosyl-amino ) caproic acid were the most potent antineoplastic agents in the ehrlich ascites carcinoma screen .
NA
{ "id": "C0001898", "name": "l-alanine", "pos": [ 66, 75 ] }
{ "id": "C0000392", "name": "beta-alanine", "pos": [ 78, 90 ] }
mean hb f was 10.5 % and 2,3-diphosphoglycerate ( 2,3-dpg ) values were higher in sicilian homozygotes than in black usa counterparts ( 21.79 mumol/g hb vs 15.16 ) .
NA
{ "id": "C0015936", "name": "hb f", "pos": [ 5, 9 ] }
{ "id": "C0019046", "name": "hb", "pos": [ 150, 152 ] }
relative abilities of external monovalent cations to inhibit active na transport were h greater than li greater than k greater than rb greater than cs greater than choline .
NA
{ "id": "C0007449", "name": "monovalent cations", "pos": [ 31, 49 ] }
{ "id": "C0033727", "name": "h", "pos": [ 165, 166 ] }
relative abilities of external monovalent anions to stimulate active na transport were i greater than br greater than cl .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 42, 48 ] }
{ "id": "C0021966", "name": "i", "pos": [ 87, 88 ] }
the ability of different anions and cations to alter na transport suggests that externally located charged groups act as important barriers or filters to ion movement .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 25, 31 ] }
{ "id": "C0022023", "name": "ion", "pos": [ 154, 157 ] }
the ability of different anions and cations to alter na transport suggests that externally located charged groups act as important barriers or filters to ion movement .
NA
{ "id": "C0007447", "name": "cations", "pos": [ 36, 43 ] }
{ "id": "C0022023", "name": "ion", "pos": [ 154, 157 ] }
the study provided support for this assumption and has important implications for educating the general public about sickle cell disease and sickle cell trait .
NA
{ "id": "C0002895", "name": "sickle cell disease", "pos": [ 117, 136 ] }
{ "id": "C0037054", "name": "sickle cell trait", "pos": [ 141, 158 ] }
the spectrum of cardiac trauma resulting from blunt injuries to the chest or decelerating injuries is wide and ranges from mild cardiac contusion to cardiac rupture .
NA
{ "id": "C0043251", "name": "trauma", "pos": [ 24, 30 ] }
{ "id": "C0043253", "name": "blunt injuries", "pos": [ 46, 60 ] }
unlike other acute leukemia viruses , which can transform various undifferentiated cells , have large unique sequence cellular gene inserts fused to helper virus gag genes , and have one known genome-length intracellular mrna , the spleen focus-forming virus transforms only specific hematopoietic stem cells , is an env gene rather than a gag gene recombinant virus , and has a second distinct and smaller class of intracellular mrna .
NA
{ "id": "C0007634", "name": "cellular", "pos": [ 118, 126 ] }
{ "id": "C0018956", "name": "hematopoietic stem cells", "pos": [ 284, 308 ] }
in light of previous reports that some of the proteins identified as phosphoproteins have regulatory functions , the data suggest that phosphorylation may modify the activity of regulatory proteins in herpes simplex virus-infected cells .
NA
{ "id": "C0033684", "name": "proteins", "pos": [ 46, 54 ] }
{ "id": "C0031689", "name": "phosphoproteins", "pos": [ 69, 84 ] }
various species of viral dna were also analyzed by the agarose gel-dna transfer procedure of southern .
NA
{ "id": "C0012939", "name": "viral dna", "pos": [ 19, 28 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 67, 70 ] }
the major viral dna species was found to migrate as a double-stranded linear dna of 5.7 x 10 ( 6 ) daltons .
NA
{ "id": "C0012939", "name": "viral", "pos": [ 10, 15 ] }
{ "id": "C0012854", "name": "double-stranded", "pos": [ 54, 69 ] }
our results indicate that the fv-1 restriction does not grossly affect the formation of linear double-stranded viral dna , but prevents the accumulation of closed circular viral dna .
NA
{ "id": "C0012854", "name": "double-stranded", "pos": [ 95, 110 ] }
{ "id": "C0012925", "name": "circular", "pos": [ 163, 171 ] }
the progeny of the cross were analyzed for endogenous viral loci by cleavage of embryo dna with restriction endonuclease ssti , electrophoretic separation of the resulting fragments , and identification of bands containing viral sequences by hybridization of the dna to radiolabeled viral rna .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 87, 90 ] }
{ "id": "C0012939", "name": "viral", "pos": [ 283, 288 ] }
gangliosides were compared with glycoproteins as potential receptors for sendai virus by incorporating measured amounts of the glycoconjugates into lecithin-cholesterol liposomes and measuring binding by a hemagglutination assay with sheep erythrocytes .
NA
{ "id": "C0017968", "name": "glycoproteins", "pos": [ 32, 45 ] }
{ "id": "C0017906", "name": "glycoconjugates", "pos": [ 127, 142 ] }
in addition to the full-genome-length 6-kilobase pair linear dna , a 5.4-kilobase pair circular dna molecule , an incomplete linear dna molecule , and a 600-base pair molecule were detected .
NA
{ "id": "C0012925", "name": "circular dna", "pos": [ 87, 99 ] }
{ "id": "C0012854", "name": "dna molecule", "pos": [ 132, 144 ] }
the patterns of distribution of viral dna sequences in these lines , as revealed by blot analysis , suggest colinear integration of the intact viral genome into the cellular dna .
NA
{ "id": "C0012939", "name": "viral dna", "pos": [ 32, 41 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 174, 177 ] }
the separation of the membrane glycoprotein e1 from the peplomeric glycoprotein e2 permitted preparation of antisera against these isolated proteins .
NA
{ "id": "C0025248", "name": "membrane glycoprotein", "pos": [ 22, 43 ] }
{ "id": "C0017968", "name": "glycoprotein", "pos": [ 67, 79 ] }
throughout the course of the viral infection , the predominant species of viral dna was that of a linear double-stranded molecule containing ribonucleotides covalently joined to the dna .
NA
{ "id": "C0012939", "name": "viral dna", "pos": [ 74, 83 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 182, 185 ] }
in cells infected with two of the mutants ( tsn and tsie13 ) , normal maturation of viral dna occurred after shiftdown of the cells to the permissive temperature in the presence of cycloheximide , indicating that the temperature-sensitive proteins involved in dna maturation became functional after shiftdown .
NA
{ "id": "C0012939", "name": "viral dna", "pos": [ 84, 93 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 260, 263 ] }
furthermore , because cycloheximide reduces maturation of dna in wild-type-infected cells but not in cells infected with these two mutants , we conclude that a protein ( s ) necessary for the maturation of concatemeric dna , which is present in limiting amounts during the normal course of infection , accumulated in the mutant-infected cells at the nonpermissive temperature .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 58, 61 ] }
{ "id": "C1257941", "name": "concatemeric dna", "pos": [ 206, 222 ] }
the ability of the two early simian virus 40 ( sv40 ) coded proteins , the large and small t-antigens , to abortively induce the disappearance of cytoplasmic actin-containing networks in cultured cells has been studied in rat embryo fibroblasts after microinjection of intact sv40 dna , dna fragments from the early region of sv40 , and a purified sv40 large t-antigen related protein ( the d2 hybrid protein ) isolated from cells infected with the adenovirus-sv40 hybrid virus ad2+d2 .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 233, 244 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 425, 430 ] }
by contrast , injection of wild-type sv40 dna or a dna fragment containing the entire region coding for a small-t antigen leads to the disruption of actin cable networks within 24 h of injection .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 42, 45 ] }
{ "id": "C0000702", "name": "a dna", "pos": [ 49, 54 ] }
epidermal growth factor also causes loss of actin cables in rat embryo fibroblasts or rat 1 cells ( an established rat embryo line ) , but only after exposure of the cells to epidermal growth factor in the culture medium and not after injection of epidermal growth factor into the cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 71, 82 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 281, 286 ] }
we analyzed total cellular dna from various hybrid clones for the presence of viral sequences by molecular hybridization and used the southern blot hybridization procedure to identify viral dna in cellular restriction endonuclease fragments .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 27, 30 ] }
{ "id": "C0012939", "name": "viral dna", "pos": [ 184, 193 ] }
infection of jls-v9 cells in culture with rauscher murine leukemia virus induced the appearance on the cell surface of two classes of viral proteins : rauscher murine leukemia virus gp70 , and glycoproteins related to the viral core ( gag ) proteins with apparent molecular weights in sodium dodecyl sulfate polyacrylamide gels of 80 x 10 ( 3 ) and 95 x 10 ( 3 ) .
NA
{ "id": "C0042736", "name": "viral proteins", "pos": [ 134, 148 ] }
{ "id": "C0033684", "name": "proteins", "pos": [ 241, 249 ] }
when an apparently favorable postoperative course is suddenly complicated by intestinal obstruction intussusception must be considered as the most likely cause .
NA
{ "id": "C0021843", "name": "intestinal obstruction", "pos": [ 77, 99 ] }
{ "id": "C0021933", "name": "intussusception", "pos": [ 100, 115 ] }
norepinephrine and epinephrine excretion , plasma renin activity and plasma cortisol concentration were determined first in recumbency and then during 45 degree head-up tilting .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 0, 14 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 19, 30 ] }
( 1 ) disarray of myofibers , ( 2 ) hypertrophy of myofibers , ( 3 ) scarcity of myofibrils , ( 4 ) nuclear changes , ( 5 ) vacuolization , ( 6 ) proliferation of collagen fibers , ( 7 ) endocardial thickening , ( 8 ) interstitial edema , ( 9 ) cell infiltration , ( 10 ) fatty infiltration and ( 11 ) basophile degeneration , were graded in five degrees ( - to 4+ ) or two degrees ( - or + ) depending upon the severity and the extent of each finding .
NA
{ "id": "C0013604", "name": "interstitial edema", "pos": [ 218, 236 ] }
{ "id": "C0037088", "name": "finding", "pos": [ 444, 451 ] }
although the prognosis is not generally so serious , 33 out of 50 cases of va had arrhythmias during attacks , including such serious ones as advanced av block and ventricular fibrillation .
NA
{ "id": "C0003811", "name": "arrhythmias", "pos": [ 82, 93 ] }
{ "id": "C0042510", "name": "ventricular fibrillation", "pos": [ 164, 188 ] }
the efficacy on congestive heart failure of metildigoxin ( beta-methyldigoxin , md ) , a derivative of digoxin ( dx ) , which had a good absorption rate from digestive tract , was examined in a double blind study using a gorup comparison method .
NA
{ "id": "C0025132", "name": "beta-methyldigoxin", "pos": [ 59, 77 ] }
{ "id": "C0012265", "name": "digoxin", "pos": [ 103, 110 ] }
unlike the p3hr-1 parent , the hybrid was completely nonpermissive for antigens of the ebv cycle , early antigen , and viral capsid antigen .
NA
{ "id": "C0003320", "name": "antigen", "pos": [ 71, 78 ] }
{ "id": "C0003342", "name": "viral", "pos": [ 119, 124 ] }
alterations in cell nucleic acid content were detected in cells stained with acridine orange under conditions such that dna and rna contents could be measured simultaneously by flow cytometry .
NA
{ "id": "C0028606", "name": "nucleic acid", "pos": [ 20, 32 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 120, 123 ] }
these data indicated that gene ( s ) specific to f-mulv-a or a virus rescued from sffv-balb/3t3 clone a31 nonproducer cells are required for transformation in vitro of a hematopoietic stem cell present in early but absent in late bone marrow cultures .
NA
{ "id": "C0007634", "name": "cells", "pos": [ 118, 123 ] }
{ "id": "C0018956", "name": "hematopoietic stem cell", "pos": [ 170, 193 ] }
an igg2a monoclonal tl.3 antibody also completely modulated tl.3 antigens and partially modulated all antigens detected with tl.1,2,3,5 antiserum .
NA
{ "id": "C0003241", "name": "antibody", "pos": [ 25, 33 ] }
{ "id": "C0020960", "name": "antiserum", "pos": [ 136, 145 ] }
the presence of an altered intermediate michaelis constant ( km ) isoenzyme , previously shown to be a unique characteristic of rat neoplastic tissues , in these tumors was invariably detectable , though the presence of the low-km isoenzyme characteristic of the enzyme of normal tissues was also evident in many of these tumors .
NA
{ "id": "C0022173", "name": "isoenzyme", "pos": [ 66, 75 ] }
{ "id": "C0014442", "name": "enzyme", "pos": [ 263, 269 ] }
tumors originated mainly from the following sources : epidermis ( papillomas and basal cell neoplasms ) , pilosebaceous complexes of the anal region ( keratoacanthomas , cystic squamous cell tumors , and adenomas of the perianal sebaceous glands ) , and clitoral ( preputial ) glands ( adenomas and adenoacanthomas ) .
NA
{ "id": "C0030354", "name": "papillomas", "pos": [ 66, 76 ] }
{ "id": "C0206720", "name": "squamous", "pos": [ 177, 185 ] }
the low-tumorigenic variant cells were released from the surfaces of plastic dishes , from protein-coated dishes , or from monolayers of fibroblasts or endothelial cells by protease treatment much more readily than were the parent cells .
NA
{ "id": "C0007634", "name": "cells", "pos": [ 28, 33 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 137, 148 ] }
the pattern of urinary bile acids up to now renders no conclusions with respect to the underlying disease , although intrahepatic cholestasis seems to be in some way connected with disturbances in the metabolism of 3 beta-hydroxy-5-cholenoic acid , a bile acid , which exerts cholestatic effects by itself .
NA
{ "id": "C0008372", "name": "intrahepatic cholestasis", "pos": [ 117, 141 ] }
{ "id": "C0008370", "name": "cholestatic", "pos": [ 276, 287 ] }
in a girl with ullrich-turner-syndrome ( gonadal dysgenesis 45 , xo ) and growth hormone deficiency , 10 u of human growth hormone/m2 body surface area/week increased the growth rate from 2.0 to 4.1 cm/year .
NA
{ "id": "C0041408", "name": "ullrich-turner-syndrome", "pos": [ 15, 38 ] }
{ "id": "C0018051", "name": "gonadal dysgenesis", "pos": [ 41, 59 ] }
since nuclear functioning proteins must be synthesized in the cytoplasm and subsequently incorporated into the nucleus , the effect of age on the uptake and specific incorporation of several of these proteins involved in transcription was investigated .
NA
{ "id": "C0028589", "name": "nuclear", "pos": [ 6, 13 ] }
{ "id": "C0033684", "name": "proteins", "pos": [ 200, 208 ] }
we have attempted to obtain pure populations of postmitotic cells from cultures of human diploid fibroblasts by the selective elimination of replicating cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 97, 108 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 153, 158 ] }
even after prolonged exposure to 5-brdu ( 10 days ) , a small fraction of cells in early passage human fibroblast-like cultures was capable of incorporating [ 3h ] thymidine .
NA
{ "id": "C0007634", "name": "cells", "pos": [ 74, 79 ] }
{ "id": "C0016030", "name": "fibroblast", "pos": [ 103, 113 ] }
there were eight cases with supravalvular aortic stenosis , 79 with valvular aortic stenosis , 25 with hypertrophic subaortic stenosis , and 15 with subvalvular aortic stenosis .
NA
{ "id": "C0003499", "name": "supravalvular aortic stenosis", "pos": [ 28, 57 ] }
{ "id": "C0003507", "name": "valvular aortic stenosis", "pos": [ 152, 176 ] }
resistance genes also allow to select for recombinant dna phages and to minimize the loss of dna inserts which otherwise becomes significant above an insert size of about one kb .
NA
{ "id": "C0012931", "name": "recombinant dna", "pos": [ 42, 57 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 93, 96 ] }
using stable materials capable of mimicking any soft tissues of the human body -- quantitatively with respect to speed of sound , density , and attenuation coefficient and semiquantitatively with respect to scatter -- we have constructed a torso section phantom containing simulated bowel gas , kidney , kidney fat pad , liver , tumor , cyst , bony structures , and resolution fibers .
NA
{ "id": "C0027651", "name": "tumor", "pos": [ 329, 334 ] }
{ "id": "C0010709", "name": "cyst", "pos": [ 337, 341 ] }
the abscess develops from the initial stage of the focal encephalitis , often with few symptoms , after a latent stage of weeks or months to the third stage of the manifest encapsulated cerebral abscess , a macroscopicsketch of which is drawn .
NA
{ "id": "C0000833", "name": "abscess", "pos": [ 4, 11 ] }
{ "id": "C0006105", "name": "cerebral abscess", "pos": [ 186, 202 ] }
the role of the pyrimidine dimer in cell killing , dna synthesis and repair has been studied by utilizing the light-requiring dna-repair mechanism of photo-reactivation in uv-irradiated chicken-embryo fibroblasts .
NA
{ "id": "C0007634", "name": "cell", "pos": [ 36, 40 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 201, 212 ] }
the in vitro effects of 4-aminopyridine ( 4-ap ) on neuromuscular transmission were determined by microelectrode techniques in intercostal muscles from patients with myasthenia gravis ( mg ) and the eaton-lambert syndrome ( els ) , and in forelimb muscles from rats with experimental autoimmune myasthenia gravis ( eamg ) .
NA
{ "id": "C0026896", "name": "myasthenia gravis", "pos": [ 166, 183 ] }
{ "id": "C0752087", "name": "experimental autoimmune myasthenia gravis", "pos": [ 271, 312 ] }
in mg and eamg , the amplitudes of miniature endplate potentials ( mepps ) and endplate potentials ( epps ) were reduced , and there was increased sensitivity to the blocking action of d-tubocurarine ( dtc ) .
NA
{ "id": "C0026896", "name": "mg", "pos": [ 3, 5 ] }
{ "id": "C0752087", "name": "eamg", "pos": [ 10, 14 ] }