text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the 1-g chicks receiving either dose of daily estrogen showed increased ap growth hormone levels , whereas hypergravity alone did not affect growth hormone content . | NA | {
"id": "C0032016",
"name": "ap",
"pos": [
72,
74
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
141,
155
]
} |
reduced growth in 2-g birds might be due , in part , to reduced ap levels of prolactin and/or growth hormone . | NA | {
"id": "C0032016",
"name": "ap",
"pos": [
64,
66
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
94,
108
]
} |
the reactions of penicillamine with gold sodium thiomalate ( myochrysine ) , gold-albumin complexes , and gold bound to urinary and kidney cytosolic proteins were examined . | NA | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
36,
58
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
106,
110
]
} |
the reactions of penicillamine with gold sodium thiomalate ( myochrysine ) , gold-albumin complexes , and gold bound to urinary and kidney cytosolic proteins were examined . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
82,
89
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
149,
157
]
} |
the microviscosity values followed the sequence eta hdl greater than eta ldl greater than eta vldl when the lipoproteins were isolated from the plasma of rabbits fed cocoa butter , milkfat , or corn oil , hdl and ldl consist of an invariant phase in the temperature range 0 -- 50 degrees c regardless of diet . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
94,
98
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
108,
120
]
} |
lipoproteins were less fluid in fasted than in non-fasted rabbits and vldl and ldl from fasted milkfat-fed rabbits showed phase transitions . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
0,
12
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
70,
74
]
} |
further investigations are necessary to evaluate whether lipoprotein lipids or apolipoproteins are a better discriminator of the influence on atherosclerotic risk in type iia hyperlipoproteinemia . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
57,
68
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
69,
75
]
} |
however , its glycosaminoglycan ( gag ) moiety shows a composition and chromatographic behaviour compatible with hybrid or mixed chains of chondroitin-6-so4 , dermatan sulfate and heparin and/or heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
14,
31
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
139,
150
]
} |
however , its glycosaminoglycan ( gag ) moiety shows a composition and chromatographic behaviour compatible with hybrid or mixed chains of chondroitin-6-so4 , dermatan sulfate and heparin and/or heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
14,
31
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
180,
187
]
} |
however , its glycosaminoglycan ( gag ) moiety shows a composition and chromatographic behaviour compatible with hybrid or mixed chains of chondroitin-6-so4 , dermatan sulfate and heparin and/or heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
14,
31
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
195,
210
]
} |
however , its glycosaminoglycan ( gag ) moiety shows a composition and chromatographic behaviour compatible with hybrid or mixed chains of chondroitin-6-so4 , dermatan sulfate and heparin and/or heparan sulfate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
139,
150
]
} | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
159,
175
]
} |
1 the characteristics and mechanism of fluctuations in diazepam and n-desmethyldiazepam concentrations and diazepam free fraction were studied in six volunteers , who received diazepam ( 10 mg , i.v . over 20 min ) and in five chronic diazepam users . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
70,
87
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
235,
243
]
} |
2 within a day total diazepam and n-desmethyldiazepam concentrations varied significantly ( p less than 0.001 ) and were lower than predicted between 23.00 and 08.00 h and higher by 09.00 h . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
21,
29
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
36,
53
]
} |
3 the coincident diurnal variations in diazepam and n-desmethyldiazepam concentrations and the negative correlation between total diazepam concentration and diazepam free fraction ( r = 0.73 , p less than 0.001 ) suggest that the mechanism of the fluctuations is intravascular and tissue redistribution rather than effect on drug biotransformation . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
54,
71
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
157,
165
]
} |
astrocytomas , glioblastomas , oligodendrogliomas , spongioblastomas , ependymomas and medulloblastomas contained relatively high amounts of gfa , up to 85 times the concentration in parietal grey substance of normal human brain . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
0,
12
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
15,
28
]
} |
this suggests that protons and/or hydroxyls cross lipid bilayers by a different mechanism than do other monovalent cations and anions . | NA | {
"id": "C0033727",
"name": "protons",
"pos": [
19,
26
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
104,
122
]
} |
a second type of [ 2fe-2s ] cluster , called center s-2 , that has been proposed to be present in purified preparations of succinate dehydrogenase and isolated complex ii ( ohnishi , t. , winter , d.b. , lim , j. and king , t.e . ( 1973 ) biochem . biophys . res . commun . 53 , 231 -- 237 ) is an artifact introduced by the purification procedure . | NA | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
123,
146
]
} | {
"id": "C0283592",
"name": "complex",
"pos": [
160,
167
]
} |
the venom proteinase thus appears to activate inactive renin via an activation of endogenous plasma proteinases . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
10,
20
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
100,
111
]
} |
by destroying proteinase inhibitors at the same time as it activates endogenous proteinases , bitis arietans metalloproteinase would appear to be particularly useful for studies of the activation of inactive renin in human plasma , since endogenous proteinases are then free to activate inactive renin without subsequent inhibition by endogenous proteinase inhibitors . | NA | {
"id": "C0025543",
"name": "metalloproteinase",
"pos": [
109,
126
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
249,
260
]
} |
chromatographic analysis of the products obtained by pronase digestion of the 9-beta-d-arabinofuranosyl-6- [ 35s ] thiopurine-enzyme complex suggests that disulfide bond formation occurs between the inhibitor and a cysteine residue located in or near the active center of the enzyme . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
126,
140
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
276,
282
]
} |
the km values of the respective enzymes for atp and adp were similar , but the km ( amp ) of the liver isozyme was about one-fifth of that of the muscle isozyme . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
32,
39
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
153,
160
]
} |
the addition of sodium pyrophosphate to the tryptophanyl-adenylate-enzyme complex restores the absorbance and fluorescence amplitude observed prior to the addition of atp to the enzyme . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
67,
81
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
178,
184
]
} |
vhdl2 consisted principally in lipoprotein d and two lipoproteins immunologically apparented to apolipoprotein a i , called lp a i1 and lp a i2 . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
31,
42
]
} | {
"id": "C0065058",
"name": "lp a",
"pos": [
136,
140
]
} |
the weight , the tyrosine hydroxylase ( th ) activity and the catecholamine ( noradrenaline and adrenaline ) content of young rat adrenals have been measured from birth to 20 days after birth in relation to hypo- and hyperthyroidism . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
78,
91
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} |
in in vitro experiments the effect of bacterial endotoxin ( lipopolysaccharide e. coli o 26 : b 6 ) on the ingestion , nbt reduction , and the formation of cytoplasmic vacuoles of polymorphonuclear leukocytes in the atmosphere of 21 vol- % o2 and 99.9 vol- % n2 , respectively , was tested . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
38,
57
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
60,
78
]
} |
newly synthesized dipyrido [ 4,3-b ] [ 3,4-f ] indole compounds have a structural similarity with the dna intercalating agents ellipticines ( pyrido-carbazoles ) . | NA | {
"id": "C0013901",
"name": "ellipticines",
"pos": [
127,
139
]
} | {
"id": "C0006974",
"name": "carbazoles",
"pos": [
149,
159
]
} |
in an attempt to improve the management of the perineal wound after abdominoperineal excision of the rectum we have assessed the value of foam elastomer , a catalysed silicone polymer dressing . | NA | {
"id": "C0013766",
"name": "elastomer",
"pos": [
143,
152
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
176,
183
]
} |
while control rats drank the normally aversive sodium solution as well as water after formalin injection , colchicine-treated animals failed to ingest the sodium solution but did consume the expected amount of water in order to compensate for hypovolemia . | NA | {
"id": "C1163679",
"name": "water",
"pos": [
74,
79
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
210,
215
]
} |
plasma concentrations of epinephrine and norepinephrine were measured during profound hypothermia and total circulatory arrest in infants under one year of age undergoing surgical correction of congenital cardiac defects . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} |
there was no significant change in either epinephrine or norepinephrine levels during surface cooling to 28 degrees c . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
57,
71
]
} |
the mean plasma norepinephrine concentration rose from 466 pg/ml ( se +/- 81 ) at circulatory arrest to 4543 pg/ml ( se +/- 2058 ) on rewarming bypass ( p less than 0.02 ) , while the mean plasma epinephrine concentration rose from 218 pg/ml ( se +/- 54 ) at circulatory arrest to 3724 pg/ml ( se +/- 1064 ) on rewarming bypass ( p less than 0.02 ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
196,
207
]
} |
circulating epinephrine and norepinephrine levels were measured during cardiopulmonary bypass in patients anaesthetized with halothane . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
28,
42
]
} |
during the period of hypothermia the blood ph was maintained at 7.6 and serum magnesium concentration was increased to an average of 2.1 mmol/l by parenteral infusion of magnesium sulfate . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
78,
87
]
} | {
"id": "C0024480",
"name": "magnesium",
"pos": [
170,
179
]
} |
giardiasis and other intestinal parasitic infections in a manitoba residential school for the mentally retarded . | NA | {
"id": "C0017536",
"name": "giardiasis",
"pos": [
0,
10
]
} | {
"id": "C0021832",
"name": "intestinal parasitic infections",
"pos": [
21,
52
]
} |
young children should only be accepted in a dialysis-transplantation program that has a medical staff expert in meeting the specific needs of such children . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
0,
5
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
147,
155
]
} |
preincubation with oxidized dextran resulted in a rapid loss of up to 80 % of the ability of the enzyme preparation to synthesize polysaccharide from sucrose , but there was no loss of enzyme activity when the oxidized dextrans were reduced with sodium borohydride before preincubation with enzyme . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
28,
35
]
} | {
"id": "C0011806",
"name": "dextrans",
"pos": [
219,
227
]
} |
it is suggested that further study of the qrs waveform at the initiation and termination of ventricular tachycardia will elucidate the mechanisms and types of tachycardias . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
92,
115
]
} | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
159,
171
]
} |
vasopressin and oxytocin were specifically demonstrated in the rat brain using the unlabelled antibody-enzyme method and purification of the first antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
94,
102
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
147,
156
]
} |
the mrna has a 5 ' noncoding region of 24 nucleotides , excluding the m5g of the cap , and encodes a polypeptide which is 139 amino acids long and unusually rich in serine and alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
126,
137
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
176,
183
]
} |
analytical density gradient centrifugation suggests that up to 60 % of the dna in the additional segments may be in the form of satellite dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
75,
78
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
128,
141
]
} |
the data suggest that the majority if not all of the t dna is integrated into plant dna , that preferred regions of the ti plasmid serve as the points of attachment to plant dna and that the t dna can be linked to more than one site in the plant genome . | NA | {
"id": "C0242964",
"name": "plant dna",
"pos": [
78,
87
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
193,
196
]
} |
in this short review consideration is given to some aspects of induction of antitumor antibodies , techniques for binding of various chemotherapeutic agents to antibodies , immunochemotherapy with oncostatic-antibody complexes and their mode of action , and future prospects of this form of therapy . | NA | {
"id": "C0003251",
"name": "antitumor antibodies",
"pos": [
76,
96
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
160,
170
]
} |
angiotensin ii , plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
0,
14
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
97,
106
]
} |
we describe a method for the simultaneous liquid-chromatographic determination of ethosuximide , ethylphenacemide , primidone , phenobarbital , carbamazepine , and phenytoin in serum . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
116,
125
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
128,
141
]
} |
the results , when compared with those by gas chromatography , gave correlation coefficients of 0.936 for phenytoin , 0.977 for phenobarbital , and 0.939 for primidone . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
128,
141
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
158,
167
]
} |
chromosome studies were performed on peripheral blood lymphocytes of 28 patients with connective tissue disease ( 6 with progressive systemic sclerosis , 6 with systemic lupus erythematosus , 6 with anti-nuclear antibody positive rheumatoid arthritis , 6 with anti-nuclear antibody negative rheumatoid arthritis , and 4 with mixed connective tissue disease ) and on 17 controls to determine the frequency of spontaneous as well as x-ray ( 75 rads ) induced aberrations . | NA | {
"id": "C0009782",
"name": "connective tissue disease",
"pos": [
86,
111
]
} | {
"id": "C0036421",
"name": "progressive systemic sclerosis",
"pos": [
121,
151
]
} |
chromosome studies were performed on peripheral blood lymphocytes of 28 patients with connective tissue disease ( 6 with progressive systemic sclerosis , 6 with systemic lupus erythematosus , 6 with anti-nuclear antibody positive rheumatoid arthritis , 6 with anti-nuclear antibody negative rheumatoid arthritis , and 4 with mixed connective tissue disease ) and on 17 controls to determine the frequency of spontaneous as well as x-ray ( 75 rads ) induced aberrations . | NA | {
"id": "C0009782",
"name": "connective tissue disease",
"pos": [
86,
111
]
} | {
"id": "C0026272",
"name": "mixed connective tissue disease",
"pos": [
325,
356
]
} |
when patients were categorized into specific clinically designated connective tissue disease subdivisions for comparison with the controls , only x-irradiated cells from the progressive systemic sclerosis group displayed significantly elevated levels of total chromosomal aberrations over those of the control group . | NA | {
"id": "C0009782",
"name": "connective tissue disease",
"pos": [
67,
92
]
} | {
"id": "C0036421",
"name": "progressive systemic sclerosis",
"pos": [
174,
204
]
} |
the duration of the disease and the renal histopathological changes were correlated with the urinary total protein and albumin excretion , the sieving coefficients of five proteins , the selectivity angle based on relative clearances of four proteins , and the excretion of beta-2-microglobulin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
119,
126
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
242,
250
]
} |
oral quinidine is available either as relatively rapidly absorbed conventional tablets ( usually quinidine sulphate ) or as a variety of slowly absorbed sustained release preparations . | NA | {
"id": "C0034414",
"name": "quinidine",
"pos": [
5,
14
]
} | {
"id": "C0034415",
"name": "quinidine sulphate",
"pos": [
97,
115
]
} |
approximately 80 % of the hepatic glutathione was present in the reduced form in both patient groups and it is concluded that although free-radical mediated damage might be implicated in the pathogenesis of tissue damage due to iron overload no significant defect in these protective mechanisms can be demonstrated . | NA | {
"id": "C0016693",
"name": "free-radical",
"pos": [
135,
147
]
} | {
"id": "C0028128",
"name": "no",
"pos": [
242,
244
]
} |
strength-duration curves were formed both for excitation ( production of a single extrasystole ) and for specific degrees of arrhythmia . | NA | {
"id": "C0340464",
"name": "extrasystole",
"pos": [
82,
94
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
125,
135
]
} |
a double-blind trial was carried out in 24 patients with acute gout to compare the efficacy and tolerance of feprazone , a non-steroidal anti-inflammatory drug , with that of phenylbutazone . | NA | {
"id": "C0033056",
"name": "feprazone",
"pos": [
109,
118
]
} | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
175,
189
]
} |
a new synthetic oral retinoid , 13-cis retinoic acid , is fairly well tolerated in patients and appears to be effective in those with darier 's disease and lamellar ichthyosis . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
21,
29
]
} | {
"id": "C0022265",
"name": "13-cis retinoic acid",
"pos": [
32,
52
]
} |
despite its generally lower activity , thiamphenicol exhibited equal or greater activity against these two species than did chloramphenicol . | NA | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
39,
52
]
} | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
124,
139
]
} |
the in vitro activity of cefotaxime ( hr 756 ) was tested in comparison with cefuroxime , cefamondole , cefoxitin , cefazolin , ampicillin , mezlocilline , gentamicin and amicacin . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
25,
35
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
77,
87
]
} |
the in vitro activity of cefotaxime ( hr 756 ) was tested in comparison with cefuroxime , cefamondole , cefoxitin , cefazolin , ampicillin , mezlocilline , gentamicin and amicacin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
128,
138
]
} | {
"id": "C0025893",
"name": "mezlocilline",
"pos": [
141,
153
]
} |
morphine and the opioid peptides [ d-ala2 , d-leu5 ] enkephalin and beta-endorphin have also been shown to decrease dopamine ( da ) release by nerve terminals in the median eminence . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
17,
32
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
53,
63
]
} |
using an antiserum to gamma-endorphin which shows little cross-reactivity with beta-lipotropin ( beta-lph ) and beta-endorphin , it has been demonstrated that gamm-endorphin is present in all cells of the intermediate lobe and the corticotropic cells of the anterior lobe . | NA | {
"id": "C0061041",
"name": "gamma-endorphin",
"pos": [
22,
37
]
} | {
"id": "C0014242",
"name": "endorphin",
"pos": [
164,
173
]
} |
the major c21-17-hydroxysteroids and c19-steroids formed from progesterone by the testes of immature golden hamsters were 5 beta- and 5 alpha-steroids , such as 3 alpha,17-dihydroxy-5 beta-pregnan-20-one , etiocholanolone , 5 beta-androstane-3 alpha,17 beta-diol , 3 alpha,17-dihydroxy-5 alpha-pregnan-20-one , androsterone , and 5 alpha-androstane-3 alpha,17 beta-diol . | NA | {
"id": "C0020393",
"name": "hydroxysteroids",
"pos": [
17,
32
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
142,
150
]
} |
the major c21-17-hydroxysteroids and c19-steroids formed from progesterone by the testes of immature golden hamsters were 5 beta- and 5 alpha-steroids , such as 3 alpha,17-dihydroxy-5 beta-pregnan-20-one , etiocholanolone , 5 beta-androstane-3 alpha,17 beta-diol , 3 alpha,17-dihydroxy-5 alpha-pregnan-20-one , androsterone , and 5 alpha-androstane-3 alpha,17 beta-diol . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
24,
32
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
338,
348
]
} |
the uterine contents of norepinephrine , epinephrine , dopamine , and prostaglandins f and e were determined on each day of the rat estrous cycle . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
24,
38
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
41,
52
]
} |
the dna-binding protein isolated from infected cells after a short 'pulse ' of [ 35s ] methionine has a molecular weight which corresponds to that of the dephosphorylated protein . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
4,
23
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
171,
178
]
} |
multiplication-stimulating activity ( msa ) refers to a family of insulin-like growth factors that have been purified from serum-free medium conditioned by a buffalo rat liver cell line ( brl-3a ) . | NA | {
"id": "C0021666",
"name": "multiplication-stimulating activity",
"pos": [
0,
35
]
} | {
"id": "C0037657",
"name": "insulin-like",
"pos": [
66,
78
]
} |
one of these polypeptides , designated msa ii-1 , previously has been used to study the relationship of the activity to the insulin-like growth factors ( somatomedins ) purified from human plasma . | NA | {
"id": "C0021666",
"name": "msa",
"pos": [
39,
42
]
} | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
154,
166
]
} |
in a radioimmunoassay utilizing 125i-msa iii-2 and a purified antibody subpopulation , the human somatomedins ( somatomedin a , insulin-like growth factor i and ii ) showed weak , but significant cross-reactivity : insulin-like growth factor ii was 10 % as potent as msa ii . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
97,
109
]
} | {
"id": "C0021665",
"name": "insulin-like growth factor i",
"pos": [
215,
243
]
} |
in a radioimmunoassay utilizing 125i-msa iii-2 and a purified antibody subpopulation , the human somatomedins ( somatomedin a , insulin-like growth factor i and ii ) showed weak , but significant cross-reactivity : insulin-like growth factor ii was 10 % as potent as msa ii . | NA | {
"id": "C0037657",
"name": "somatomedins",
"pos": [
97,
109
]
} | {
"id": "C0021666",
"name": "msa",
"pos": [
267,
270
]
} |
both types of heavy meromyosin were denatured by sodium dodecylsulfate and used to immunize guinea-pigs after chromatography on sephadex g-10 to remove excess dodecylsulfate . | NA | {
"id": "C0037506",
"name": "sodium dodecylsulfate",
"pos": [
49,
70
]
} | {
"id": "C0058632",
"name": "dodecylsulfate",
"pos": [
159,
173
]
} |
the administration of estrogen caused an increase of type i adenosine-3',5'-monophosphate-dependent ( camp-dependent ) protein kinase and a slight decrease of type ii camp-dependent protein kinase . | NA | {
"id": "C0010531",
"name": "camp-dependent",
"pos": [
102,
116
]
} | {
"id": "C0033639",
"name": "type ii camp-dependent protein kinase",
"pos": [
159,
196
]
} |
the level of type i adenosine 3',5'-monophosphate-dependent ( camp-dependent ) protein kinase was higher than that of type ii camp-dependent protein kinase at the proliferative phase . | NA | {
"id": "C0010531",
"name": "camp-dependent",
"pos": [
62,
76
]
} | {
"id": "C0033639",
"name": "type ii camp-dependent protein kinase",
"pos": [
118,
155
]
} |
following a description of the genetic aspects of the human histocompatibility antigens system hla and its principle typing methods , this paper reviews the relationship between hla antigens , transplantation immunology and certain diseases . | NA | {
"id": "C0019728",
"name": "a",
"pos": [
10,
11
]
} | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
178,
190
]
} |
the data indicate that different viral antigen-cell membrane interactions govern the activation phase and effector phase of antigen-primed t cell populations , while sensitization of unprimed cells is dependent on the presence of adherent , perhaps antigen-presenting cells . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
33,
46
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
249,
256
]
} |
it is shown that removal of nylon-adherent cells from the responding cell population strongly reduced ctl generation , whereas direct removal of ig+ , phagocytic or plastic-adherent cells had no effect . | NA | {
"id": "C0028736",
"name": "nylon",
"pos": [
28,
33
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
165,
172
]
} |
these results suggest that baclofen 's antinociceptive action may be mediated in part by a supraspinal , gabaergic substrate , in addition to a spinal component which may not directly involve gaba . | NA | {
"id": "C0004609",
"name": "baclofen 's",
"pos": [
27,
38
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
192,
196
]
} |
general anesthetics alter the in vivo vascular smooth muscle responses to topically applied vasoactive substances such as epinephrine or norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
137,
151
]
} |
contractile effects of oxytocin , prostaglandin f2 alpha , acetylcholine , kcl , rbcl , and bacl2 in the presence of mn2+ and la3+ ions and other cations were studied in the rat myometrium at 37 degrees c . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
131,
135
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
146,
153
]
} |
the administration of copper in the form of copper sulphate ( 12.7 mg , i.e . 200 mumol cu2+/rat/day ) raised polyphenoloxidase activity ( the ceruloplasmin level ) , the increase being particularly marked on the first four days . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
22,
28
]
} | {
"id": "C0056301",
"name": "copper sulphate",
"pos": [
44,
59
]
} |
a 57-year-old man with skin psoriasis and psoriatic arthropathy , in whom an igg-k monoclonal immunoglobulin was identified , is reported . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
28,
37
]
} | {
"id": "C0003872",
"name": "psoriatic arthropathy",
"pos": [
42,
63
]
} |
a system is described in which human diploid fibroblasts or other anchorage dependent cells may be conveniently cultured . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
45,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
86,
91
]
} |
the proposed micro-elisa assay by means of the double antibody method involves three steps : adsorption of type specific antiserum on micro-wells ; | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
54,
62
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
121,
130
]
} |
human diploid fibroblast strains wi-38 and mrc 5 can be routinely grown in eagles medium to densities between 2x10 ( 5 ) and 1x10 ( 5 ) cells/cm2 . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
14,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
136,
141
]
} |
effect of pretreatment ( 150 mumol/kg i.p . twice daily for 5 days ) wtih six barbiturates ( barbital , butobarbital , pentobarbital , amobarbital , phenobarbital and thiopental ) on the hepatic microsomal drug methabolizing enzyme system and biliary excretion of bromcresol green and bromsulphthalein-glutathione conjugate has been investigated in rats . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
78,
90
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
154,
162
]
} |
effect of pretreatment ( 150 mumol/kg i.p . twice daily for 5 days ) wtih six barbiturates ( barbital , butobarbital , pentobarbital , amobarbital , phenobarbital and thiopental ) on the hepatic microsomal drug methabolizing enzyme system and biliary excretion of bromcresol green and bromsulphthalein-glutathione conjugate has been investigated in rats . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
78,
90
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
119,
132
]
} |
effect of pretreatment ( 150 mumol/kg i.p . twice daily for 5 days ) wtih six barbiturates ( barbital , butobarbital , pentobarbital , amobarbital , phenobarbital and thiopental ) on the hepatic microsomal drug methabolizing enzyme system and biliary excretion of bromcresol green and bromsulphthalein-glutathione conjugate has been investigated in rats . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
78,
90
]
} | {
"id": "C0002640",
"name": "amobarbital",
"pos": [
135,
146
]
} |
decrease of antibodies to insulin , proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
26,
33
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
36,
46
]
} |
all showed antibody binding of insulin , 29 binding of proinsulin , 29 binding of pancreatic polypeptide , two binding of glucagon but none of the sera bound vasoactive intestinal peptide or somatostatin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
31,
38
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
55,
65
]
} |
the proliferative capacity of rat lens epithelial cells is higher than that of rat embryonic fibroblast systems . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
93,
103
]
} |
reactivity of immunoglobulins and complement only with areas of traumatized stratum corneum in skin explants cultured on sera containing scab provide some insight as to a possible normal physiologic role for these ubiquitous complement-fixing autoantibodies . | NA | {
"id": "C0003241",
"name": "scab",
"pos": [
137,
141
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
243,
257
]
} |
the effect of induced metabolic acidosis ( 48 h of nh4cl ingestion , be - 10.6 +/- 1.1 ) and alkalosis ( 43 h of nahco3- ingestion be 8.8 +/- 1.6 ) on arterial and lumber csf ph , pco2 , and hco3- and ventilatory responses to co2 and to hypoxia was assessed in five healthy men . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
113,
119
]
} | {
"id": "C0005367",
"name": "hco3",
"pos": [
191,
195
]
} |
the amount of 5-fluorouracil found in deoxyribonucleic acid as fluorodeoxyuridylate increased 50-fold when the cells were deficient in both deoxyuridine triphosphatase and uracil-deoxyribonucleic acid glycosylase activities . | NA | {
"id": "C0016360",
"name": "fluorouracil",
"pos": [
16,
28
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
172,
178
]
} |
therefore , the same mechanisms which excluded uracil from deoxyribonucleic acid in vivo also excluded 5-fluorouracil . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
47,
53
]
} | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
103,
117
]
} |
even though purified uracil-deoxyribonucleic acid glycosylase excised 5-fluorouracil from deoxyribonucleic acid at only 5 % the rate with which it excised uracil , most of the 5-fluorouracil excised from deoxyribonucleic acid in vivo was apparently excised directly by uracil-deoxyribonucleic acid glycosylase rather than by repair initiated by excision of uracil . | NA | {
"id": "C0016360",
"name": "fluorouracil",
"pos": [
72,
84
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
357,
363
]
} |
a whole-cell product isotope discrimination of 1.5 favoring hydrogen over deuterium was observed in methane production in 81 atom % deuterated water . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
60,
68
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
74,
83
]
} |
it protected single-stranded dna against nuclease s ( 1 ) action but did not protect native dna against deoxyribonuclease i action . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
13,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
92,
95
]
} |
nostoc preincubated under acetylene evolved hydrogen in the light even in the presence of nitrogen for at least 2 h , with a 15-fold increase as compared to the unconditioned cells . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
44,
52
]
} | {
"id": "C0011744",
"name": "2 h",
"pos": [
112,
115
]
} |
for a threefold increase in growth rate , the fractional synthesis of polymerase ( relative to protein ) increased 1.5-fold , whereas the fractional synthesis of ribosomal protein increased 2.2-fold . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
95,
102
]
} | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
162,
179
]
} |
the number of active rna polymerase molecules was determined from the synthesis rates of stable and messenger rna and the known rna chain growth rates . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
100,
113
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
128,
131
]
} |
after adsorption of the antiserum with diploid cells , antibodies remained that reacted specifically with the mannan from haploid cells . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
24,
33
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
55,
65
]
} |
we found that the dna chain elongation rate in polyamine-deficient cells was about half that of putrescine- or spermidine-supplemented cells . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
96,
106
]
} | {
"id": "C0037871",
"name": "supplemented",
"pos": [
122,
134
]
} |
an analysis of transposon-induced mutants shows that salmonella typhimurium possesses two major isozymes of acetohydroxy acid synthase , the enzymes which mediate the first common step in isoleucine and valine biosynthesis . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
96,
104
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
141,
148
]
} |
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