text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
4-ap appears to facilitate neuromuscular transmission in eamg , mg , and els by increasing the neurally evoked transmitter release , thus overcoming either the pre- or the postsynaptic neuromuscular blockade . | NA | {
"id": "C0752087",
"name": "eamg",
"pos": [
57,
61
]
} | {
"id": "C0026896",
"name": "mg",
"pos": [
64,
66
]
} |
treatment of cells with the phorbol ester 12-o-tetradecanoyl phorbol-13-acetate ( tpa ) and retinoic acid shows poor antagonism between these compounds on egf binding . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
28,
41
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol-13-acetate",
"pos": [
42,
79
]
} |
apamin , a peptide of bee venom , was shown to inhibit the relaxant responses of guinea-pig taenia caeci to atp , noradrenaline , adenosine and , less effectively , to stimulation of noradrenergic inhibitory nerves . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
0,
6
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
22,
31
]
} |
parallel bioassay of physalaemin and kassinin , a tachykinin dodecapeptide from the skin of the african frog kassina senegalensis . | NA | {
"id": "C0022528",
"name": "kassinin",
"pos": [
37,
45
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
50,
60
]
} |
kassinin , a tachykinin dodecapeptide isolated from the skin of the african frog kassina senegalensis was submitted to parallel bioassay with physalaemin , eledoisin and substance p , three major representatives of the tachykinin peptide family . | NA | {
"id": "C0022528",
"name": "kassinin",
"pos": [
0,
8
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
219,
229
]
} |
kassinin , a tachykinin dodecapeptide isolated from the skin of the african frog kassina senegalensis was submitted to parallel bioassay with physalaemin , eledoisin and substance p , three major representatives of the tachykinin peptide family . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
170,
181
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
219,
229
]
} |
however , among the examined tachykinins kassinin was the poorest stimulant of salivary secretion and the weakest hypotensive agent , while displaying very powerful stimulant effects on different smooth muscle preparations , especially on isolated preparations of urinary bladder . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
29,
40
]
} | {
"id": "C0022528",
"name": "kassinin",
"pos": [
41,
49
]
} |
kassinin differed from the other tachykinins also for its more gradual and sustained action on several in situ and isolated preparations . | NA | {
"id": "C0022528",
"name": "kassinin",
"pos": [
0,
8
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
33,
44
]
} |
the anastomosis apparatus consists of two rings of ertalyte ( polyester-polyethyleneterephtalate ) containing two magnetic rings of polymer bonded rare earth cobalt . | NA | {
"id": "C0032474",
"name": "polyester",
"pos": [
62,
71
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
132,
139
]
} |
perinatal morbidity and mortality are known to be higher for the macrosomic neonate whose birth weight is 4500 g or more , compared with that of appropriate-weight term-size neonates . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
90,
102
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
157,
163
]
} |
seven patients with recurrent molar pregnancy were managed at the new england trophoblastic disease center ( netdc ) between july 1965 and december 1978 . | NA | {
"id": "C0020217",
"name": "molar pregnancy",
"pos": [
30,
45
]
} | {
"id": "C2931618",
"name": "trophoblastic disease",
"pos": [
78,
99
]
} |
following permanent ischemia ( 33 animals sacrified after 1 , 6 , 24 and 48 hours ) , there appeared a reproducible extended transversal infarction marked by a uniform sequence of histologic , histoenzymatic and ultrastructural changes . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
20,
28
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
137,
147
]
} |
in a newborn infant with heart failure and hepatomegaly the radiological findings suggested hepatic haemangioendothelioma , but subsequently the tumour proved to be a hamartoma . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
145,
151
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
167,
176
]
} |
in the immotile cilia syndrome , transmission electron microscopy of the cilia shows abnormalities in the arrangement of the central pairs of tubules and in the dynein arms of the peripheral tubules , or in the radial spokes , we studied four nonrelated children , 9/12 , 5 , 6 , and 6 years old , with situs inversus and a history of chronic sinusitis and bronchitis ( kartagener 's syndrome ) and four children in the same age group and with the same history , but without situs inversus . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
85,
98
]
} | {
"id": "C0037221",
"name": "situs",
"pos": [
475,
480
]
} |
partial correlation coefficients describing relationships between lipids , lipoproteins , and nutrients after adjustment for age , sex , race , and quetelet index ( w/h2 ) were calculated for all children ( random and hyperlipidemic recall ) after excluding children having plasma cholesterol , triglycerides , and calories less than or equal to the first or greater than or equal to the 99th percentiles for the random recall children . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
66,
72
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
75,
87
]
} |
nutrient intake may play a small but significant role relative to lipids and lipoproteins in children and , as such , may have importance relative to pediatric precursors of atherosclerosis . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
66,
72
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
77,
89
]
} |
the water supply of the school was supplemented with a concentrated sodium fluoride solution designed to raise fluoride levels in drinking water to 1 to 5 ppm . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
68,
83
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
111,
119
]
} |
after a study about 146 cases of echinococcosis which 8 osseous localizations , indirect immunofluorescence reactions and immunoprecipitation reactions allow for comparing between right immunologic answers in hydatid cyst of liver and hydatid cyst of bone . | NA | {
"id": "C0013502",
"name": "echinococcosis",
"pos": [
33,
47
]
} | {
"id": "C0013504",
"name": "hydatid cyst of liver",
"pos": [
209,
230
]
} |
glycaemia can be measured by numerous methods , the main ones being reduction methods -- which measure both glucose and other reducing agents in the blood and are still widely used after some fifty years -- and enzymatic methods , which measure only blood glucose and , consequently , give lower values . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
108,
115
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
250,
263
]
} |
after rats were trained to differentiate between the effects of intraperitqoneal administration of 0.6 mg/kg d-amphetamine and saline , pretreatment with various neuroleptic drugs was observed to significantly inhibit d-amphetamine discrimination . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
111,
122
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
218,
231
]
} |
the attenuated drinking response of estrogen-treated rats to angiotensin i and angiotensin ii suggests either that administered angiotensin failed to gain access to the brain or that central receptors mediating thirst are less sensitive in estrogen-treated rats . | NA | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
61,
74
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
128,
139
]
} |
the attenuated drinking response of estrogen-treated rats to angiotensin i and angiotensin ii suggests either that administered angiotensin failed to gain access to the brain or that central receptors mediating thirst are less sensitive in estrogen-treated rats . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
79,
93
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
128,
139
]
} |
three hallucinogens ( d-lysergicacid diethylamide ( lsd ) , mescaline , psilocybin ) and two cannabinoid derivatives ( tetrahydrocannabinol ( thc ) , synhexyl ) were tested for their long-term effects on the eeg of the cat . | NA | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
93,
104
]
} | {
"id": "C0039663",
"name": "tetrahydrocannabinol",
"pos": [
119,
139
]
} |
chlorprothixene was the first neuroleptic of the thioxanthene group and was marketed in 1959 under the trade names of taractan and truxal . | NA | {
"id": "C0008290",
"name": "chlorprothixene",
"pos": [
0,
15
]
} | {
"id": "C0039961",
"name": "thioxanthene",
"pos": [
49,
61
]
} |
identifying premalignant disease in the parotid tumor and early preinvasive carcinoma in the submaxillary tumor lends support to the concept of malignant progression in salivary gland mixed tumors . | NA | {
"id": "C0032927",
"name": "premalignant disease",
"pos": [
12,
32
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
190,
195
]
} |
substituted benzamides ( clebopride greater than sultopride greater than sulpiride greater than metoclorpramide greater than tiapride ) displace 3h-hal but have only a very slight displacing effect towards 3h-fpt , and did not inhibit dopamine-stimulated adenylate cyclase activity . | NA | {
"id": "C0005029",
"name": "benzamides",
"pos": [
12,
22
]
} | {
"id": "C0038803",
"name": "sulpiride",
"pos": [
73,
82
]
} |
the results indicate that apomorphine elicits yawning by stimulating presynaptic dopamine receptors , and that dopaminergic inhibition and cholinergic activation are concomitantly involved in the yawning . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
81,
89
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
111,
123
]
} |
observations with levorphanol and phenazocine suggested further that dopamine , as well as opiate receptor agonism may be characteristic of the benzomorphans . | NA | {
"id": "C0031376",
"name": "phenazocine",
"pos": [
34,
45
]
} | {
"id": "C0005075",
"name": "benzomorphans",
"pos": [
144,
157
]
} |
procaine and chloroprocaine maintained rates of responding exceeding saline levels in all monkeys tested , with maximum rates generated by 0.2 mg/kg . | NA | {
"id": "C0033218",
"name": "procaine",
"pos": [
0,
8
]
} | {
"id": "C0055443",
"name": "maintained",
"pos": [
28,
38
]
} |
cytophotometric determinations of the feulgen-dna content and determination of the rna content by staining and chromic gallocyanin in combination with ribinuclease digestion lead to the conclusion that the irradiation induces no significant hyperploidy and that the irradiated neurons have the nuclear rna content that is normal at this stage of gestation . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
83,
86
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
294,
305
]
} |
40 krads and 1 x 10 ( 4 ) jm-2 , respectively , when no single-stranded ( ss ) dna was detected in the irradiated dna samples . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
56,
71
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
114,
117
]
} |
after higher doses of radiation the occurrence of ss dna or ss segments in the irradiated samples of ds dna was accompanied by an increase of peaks g and a ; | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
50,
56
]
} | {
"id": "C0012854",
"name": "ss",
"pos": [
60,
62
]
} |
the irradiation of phenothiazine derivatives in aerated solutions yields from the triplet state to the formation of singlet oxygen and more especially of superoxide ions and cation-radicals characteristic of the dye . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
61,
65
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
174,
180
]
} |
sonograms or ct scans of 25 proved cirrhotic livers , 25 normal livers , and 15 livers with diffuse disease other than cirrhosis were analyzed using a number of measurements and ratios to evaluate and quantify the frequency and possible diagnostic value of these alterations . | NA | {
"id": "C0023895",
"name": "livers",
"pos": [
45,
51
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
119,
128
]
} |
analysis of the ct findings in 35 cases of tumoral hemorrhage ( taken from 973 intracranial tumors ) revealed three distinct patterns of bleeding : ( a ) hematoma , ( b ) central hemorrhage , and ( c ) hemorrhagic infarction . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
154,
162
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
179,
189
]
} |
a similar assessment of in vivo phosphorylation of this myosin fraction indicated that phosphate incorporation may not be occurring in cardiac myosin heavy chains , but rather in another cardiac myosin-like protein which co-purifies with myosin heavy chains . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
56,
62
]
} | {
"id": "C0027100",
"name": "myosin heavy chains",
"pos": [
238,
257
]
} |
in the same time interval the erythrocyte putrescine level had decreased by 50 % , spermine by 70 % and spermidine by 80 % . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
42,
52
]
} | {
"id": "C0037871",
"name": "80",
"pos": [
118,
120
]
} |
in the same time interval the erythrocyte putrescine level had decreased by 50 % , spermine by 70 % and spermidine by 80 % . | NA | {
"id": "C0037874",
"name": "70",
"pos": [
95,
97
]
} | {
"id": "C0037871",
"name": "80",
"pos": [
118,
120
]
} |
the results from an analysis of the experimental data support the assumption that more than one concentration-dependent mechanism exists in the renal tubuli for each of the two purines , adenine and doa . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
177,
184
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
187,
194
]
} |
the interaction of lps from bacteroides fragilis , escherichia coli , salmonella typhimurium and lipid a from s. typhimurium with adhesion of human periodontal cells on plastic surfaces has been studied . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
19,
22
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
97,
104
]
} |
the results showed that lps and lipid a reduced adhesion already after 5 min at concentrations from 5 to 200 microgram/ml without influencing cell viability . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
24,
27
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
32,
39
]
} |
it could be demonstrated that lps and lipid a interact with both the cell and the substratum surface . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
30,
33
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
38,
45
]
} |
sds electrophoresis shows the marked low content of nitrogen reductase and immunoelectrophoretic test reveals the reduced amount of both nitrogenase and nitrogen reductase in the mutant cells . | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
137,
148
]
} | {
"id": "C0030016",
"name": "reductase",
"pos": [
162,
171
]
} |
the pressor effect of the cadmium was inhibited by adding 3.6 ppm of selenium or 200 ppm of zinc to the drinking water or by dissolving the cadmium in hard water rather than deionized water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
104,
118
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
184,
189
]
} |
the net increase in gaba of the denervated nigra was compared with that of the intact nigra at various times after a single injection of gama-vinyl-gaba , which irreversibly inhibits gaba transaminase . | NA | {
"id": "C0048044",
"name": "vinyl-gaba",
"pos": [
142,
152
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
183,
187
]
} |
the proteins detected in slow anterograde transport ( 1 to 2 millimeters per day ) correspond to cytoskeletal proteins described in previous papers . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
97,
118
]
} |
these various types of microspheres may be coated with pure , highly specific monoclonal antibodies obtained by the new hybridoma cell cloning techniques or with conventional antibody preparations . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
78,
99
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
175,
183
]
} |
the main features of alcoholic rhabdomyolysis-skeletal muscle necrosis , marked elevation of serum creatine phosphokinase , and myoglobinuria-were produced in rats by a combination of relatively prolonged ( 2 to 4 weeks ) exposure to ethanol and a brief period of food deprivation . | NA | {
"id": "C0035410",
"name": "of",
"pos": [
18,
20
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
128,
141
]
} |
homologies among their amino acid sequences and evidence for prohormone activity in acth , beta-lipotropin , and the putative acth-beta lipotropin precursor suggest the possibility of the presence of a previously unsuspected interrelationship in the synthesis and release of these various pituitary peptides . | NA | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
91,
106
]
} | {
"id": "C0033195",
"name": "acth-beta lipotropin precursor",
"pos": [
126,
156
]
} |
shortly after rhabdomyolysis was diagnosed , the patient developed reversible acute renal failure presumably secondary to the myoglobinuria . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
14,
28
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
126,
139
]
} |
both chef/8 and chef/16 have a normal giemsa banding pattern and constitutive heterochromatin distribution characteristic of normal diploid chinese hamster cells and exhibit relatively little chromosomal variation within their cell populations . | NA | {
"id": "C0016030",
"name": "chef",
"pos": [
5,
9
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
227,
231
]
} |
an antiserum made against purifed at iii contained antibodies with different cross-reactivities against heparin bound and non-heparin bound at iii . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} |
the only biological activity to show a marked relationship with the molecular size of the heparin fraction was the anti-xa activation activity . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
90,
97
]
} | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
115,
122
]
} |
blood platelets contain microtubule proteins ( tubulin and hmws ) which can be polymerised `` '' in vitro '' '' to form structure which resemble the microtubules seen in the intact platelet . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
24,
44
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
47,
54
]
} |
in order to investigate the etiology of idiopathic edema , clinical findings and endocrinological abnormalities were analyzed in twenty-seven patients , and the following results were obtained . | NA | {
"id": "C0013604",
"name": "edema",
"pos": [
51,
56
]
} | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
59,
76
]
} |
a high skin protoporphyrin level ( 4.36 micrograms/g wet weight ) was detected in a 14-year-old girl with erythropoietic protoporphyria who died of protoporphyrin hepatopathy cirrhosis . | NA | {
"id": "C0023895",
"name": "hepatopathy",
"pos": [
163,
174
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
175,
184
]
} |
these results demonstrate that high performance liquid chromatography can be used to determine azathioprine and 6-mercaptopurine levels in man , and that alteration in renal function does not influence early stages of azathioprine degradation . | NA | {
"id": "C0000618",
"name": "levels",
"pos": [
129,
135
]
} | {
"id": "C0004482",
"name": "azathioprine",
"pos": [
218,
230
]
} |
in a review of non-viral bullous skin diseases of domestic animals and a 4-year study of cases presented to the new york state college of veterinary medicine , we found 15 diseases : pemphigus vulgaris , pemphigus vegetans , pemphigus foliaceus , pemphigus erythematosus , bullous pemphigoid , systemic lupus erythematosus , dermatitis herpetiformis , toxic epidermal necrolysis , drug eruption , epidermolysis bullosa , epidermolysis bullosa simplex , familial acantholysis , bovine congenital porphyria , impetigo and subcorneal pustular dermatosis . | NA | {
"id": "C0014527",
"name": "epidermolysis bullosa",
"pos": [
397,
418
]
} | {
"id": "C0079298",
"name": "epidermolysis bullosa simplex",
"pos": [
421,
450
]
} |
this report describes two pregnancies complicated by hydramnios , fetal death and sacrococcygeal teratoma in the second trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
26,
37
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
113,
129
]
} |
this is in contrast to the aurosomes produced by the soluble gold salt sodium aurothiomalate where besides gold , sulphur and phosphorus are easily detected . | NA | {
"id": "C0018034",
"name": "sodium aurothiomalate",
"pos": [
71,
92
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
107,
111
]
} |
at the same time , nefa of the dysenteric bacteria contained comparatively high amount of branched and cyclopropane-bearing fatty acids . | NA | {
"id": "C0015688",
"name": "nefa",
"pos": [
19,
23
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
124,
135
]
} |
antibodies , studied by the immunochemical methods in several types of syphilis , are represented by various classes of immunoglobulins . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0021017",
"name": "classes",
"pos": [
109,
116
]
} |
the salt loading was carried out during 10 days either using catheterization ( 50-75 meq of nacl per kg of body weight ) or by means of feeding a diet with high content of the salt ( 90-100 meq per kg of body weight ) ; | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
92,
96
]
} | {
"id": "C0206136",
"name": "diet",
"pos": [
146,
150
]
} |
definite separation of somatotropin and prolactin using sodium dodecylsulphate polyacrylamide gel electrophoresis takes place in continuous systems with ph 7.0-7.2 containing acetate or chloride monovalet anions ; | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
186,
194
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
205,
211
]
} |
preadministration of alpha-tocopheryl acetate ( 30 mg per kg of body weight within 24 hrs ) caused an increase of its content in liver tissue and adrenal glands : the treatment prevented the increase of lipid peroxidation in liver tissue as well as the decrease of vitamin e and adrenaline content in adrenal glands but did not affect the ii-hydroxycorticosteroid concentration in adrenal glands and blood serum . | NA | {
"id": "C1999896",
"name": "alpha-tocopheryl acetate",
"pos": [
21,
45
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
265,
274
]
} |
suggestive abnormalities of lipid metabolism involved hyperlipidemia , hypercholesterinemia and hypertriglyceridemia ( more sharply pronounced in patients with cgn associated with the nephrotic syndrome ) as well as hyperlipoproteidemia , chiefly of types iy and iib . | NA | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
54,
68
]
} | {
"id": "C0020557",
"name": "hypertriglyceridemia",
"pos": [
96,
116
]
} |
investigations of the variations produced led to revealing an increase in the activity of phosphatases : mg2+ , na+ , k+-atpase , k+ , na+-atpase , mg2-atpase . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
121,
127
]
} | {
"id": "C0001477",
"name": "mg2-atpase",
"pos": [
148,
158
]
} |
[ effect of the parenteral administration of protein hydrolysates on body mass dynamics and the protein content in liver of rats on a protein-free diet ] . | NA | {
"id": "C0033631",
"name": "protein hydrolysates",
"pos": [
45,
65
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
134,
141
]
} |
in 98 cases of pulmonary diseases ( active and inactive sarcoidosis , idiopathic interstitial lung fibrosis [ hamman-rich ] , collagenous diseases , goodpasture syndrome , alveolar lipoid proteinosis , malignant lymphogranulomatosis and bronchial carcinoma ) and in 18 tuberculin and varidase positive , kveim negative control cases the migration inhibition factor ( mif ) was investigated . | NA | {
"id": "C0024115",
"name": "pulmonary diseases",
"pos": [
15,
33
]
} | {
"id": "C0034050",
"name": "alveolar",
"pos": [
172,
180
]
} |
cytologically , the neoplasms exhibited two types of malignant cells : an elongated , spindle-shaped , fibroblast-like cell and a larger , histocyte-like cell , often embedded in myxoid material . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
103,
113
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
154,
158
]
} |
subsequent organ enlargement was noted in 11.7 % of patients with no initial organomegaly , splenomegaly in 15 % of patients with adenopathy only and adenopathy in 15 % of patients with splenomegaly only . | NA | {
"id": "C0020564",
"name": "enlargement",
"pos": [
17,
28
]
} | {
"id": "C0038002",
"name": "splenomegaly",
"pos": [
186,
198
]
} |
d-penicillamine , a drug used clinically for the treatment of neonatal hyperbilirubinaemia , was tested for interference with the binding of bilirubin to human serum albumin by three methods : 1 ) the peroxidase technique , investigating the effect of d-penicillamine on the equilibrium concentration of unbound bilirubin in a solution containing a molar excess of albumin ; | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
154,
173
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
365,
372
]
} |
serum lipids and lipoprotein-lipids were measured in 350 danish schoolchildren , ages 7 to 18 years . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
17,
28
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
29,
35
]
} |
only in boys did serum triglyceride and vldl-cholesterol increase significantly with age , whereas the other lipoprotein-lipids remained almost constant during adolescence . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
109,
120
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
121,
127
]
} |
the antibodies to lta present in the rabbit antisera examined were found to be of the igm class . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
44,
52
]
} |
the plasma acute phase reactant pattern was studied in 124 patients with liver disease and 16 healthy individuals undergoing liver biopsy , alpha 1-antitrypsin levels were found to correlate positively with the extent of hepatocellular damage , inflammatory activity and total biopsy score . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
11,
31
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
140,
159
]
} |
in seven days the concentration of serum cholesterol decreased by 24 % and that of hdl cholesterol by 31 % . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
41,
52
]
} | {
"id": "C0023822",
"name": "hdl cholesterol",
"pos": [
83,
98
]
} |
infiltration with local anaesthetics with addition of adrenaline or noradrenaline has been used since 1910 prior to skin incision for craniotomy . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
54,
64
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} |
intensive renal sodium retention in cirrhosis with ascites ( urine natless than 20 meq/24 hr ) is very often associated with increasing pgf/pge ratio , whereas absolute urine pge2 can be found low or normal . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
140,
143
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
175,
179
]
} |
there was no correlation between the serum chromium and blood glucose levels in these patients or in a further 14 patients who were receiving glucose infusions ( chest pain without electrocardiographic or enzyme changes ) or who were diabetics . | NA | {
"id": "C0005802",
"name": "blood",
"pos": [
56,
61
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
142,
149
]
} |
regardless of the nature of gallstones , bile acid pools of stone patients with functioning gallbladder were within normal range , whereas the pools of those with non- or poorly-functioning gallbladder diminished to about two-thirds of the control . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
28,
38
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
60,
65
]
} |
lymph lipoprotein fractions were analyzed for lipid and apoprotein content and were compared to chow-fed control rats . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
6,
17
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
46,
51
]
} |
six healthy young men participated in a metabolic balance study to assess the effects of wine versus ethanol on absorption of various elements . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
89,
93
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
101,
108
]
} |
during each of four 18-day experimental periods , the subjects were fed a controlled diet plus 1 liter/day of one of the following test beverages , administered in random order : zinfandel wine , dealcoholized zinfandel wine , an aqueous ethanol solution , or deionized water . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
189,
193
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
238,
245
]
} |
urinary zinc was significantly greater during wine and ethanol administration than during administration of the nonalcoholic beverages , suggesting that alcohol may affect the metabolism or renal conservation mechanism for zinc . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
46,
50
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
153,
160
]
} |
there was increased absorption and , perhaps , also , decreased endogenous secretion of zinc during the wine and dealcoholized wine periods , as compared with ethanol and deionized water . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
104,
108
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
159,
166
]
} |
using an arbitrary scale of 1-4 based on the frequency of deposits , 3+ and 4+ deposits were identified in all five cases of lichen planus , as well as in six cases of lupus erythematosus , one of drug eruption , one of bullous pemphigoid , one of erythema nodosum , the vitiligo , vasculitis , and rothmund-thompson syndrome cases , and two cases of unspecified dermatoses ; | NA | {
"id": "C0011609",
"name": "drug eruption",
"pos": [
197,
210
]
} | {
"id": "C0014743",
"name": "erythema nodosum",
"pos": [
248,
264
]
} |
since the reaction between antithrombin iii and serine proteases is irreversible , one would expect antithrombin iii consumption in the face of pathologic intravascular coagulation and attendant generation of thrombin , ixa , xa , xia , xiia , and plasmin . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
48,
64
]
} | {
"id": "C0016016",
"name": "plasmin",
"pos": [
248,
255
]
} |
in the four children whose hi titers declined to undetectable levels , both hi and neutralizing ( nt ) antibodies had developed immediately postimmunization , and two had nt titers at follow-up despite loss of hi antibodies . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
83,
95
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
213,
223
]
} |
the occurrence of an immune complex-like disease ( with characteristics of the hcvs ) in a patient with a familial deficiency of c3 suggests that the preexisting c3 deficiency may predispose such persons to certain diseases . | NA | {
"id": "C0039082",
"name": "hcvs",
"pos": [
79,
83
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
215,
223
]
} |
in this patient , the subsequent emergence of gentamicin and amikacin resistance may have been related to the omission of intrathecal aminoglycoside . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
46,
56
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
134,
148
]
} |
the results demonstrate decreases of 61 % in litter size , 36 % in fetal body weight , and 23 % in fetal brain weight . | NA | {
"id": "C0751992",
"name": "fetal body weight",
"pos": [
67,
84
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
111,
117
]
} |
and ( 3 ) the role of certain fibroblast-like `` '' osteoclast companion cells '' '' in the attachment process of periodontal fibers onto resorptive bone surfaces . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
10,
13
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
30,
40
]
} |
the similarity in the structure-activity relationship of these agents in the avian erythrocyte and the kidney suggests that the avian erythrocyte may be a useful model for analysis both of the diuretic-sensitive transport system of the mammalian kidney , and of the molecular mechanism of loop diuretic action . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
193,
201
]
} | {
"id": "C0354100",
"name": "loop diuretic",
"pos": [
289,
302
]
} |
( - ) -norepinephrine and ( - ) -epinephrine were found to have similar efficacy and potency with ec50 's at 5.6 x 10 ( -7 ) m and 3.8 x 10 ( -7 ) m , respectively . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
7,
21
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
33,
44
]
} |
the adrenergic agonists ( - ) -norepinephrine and ( - ) -epinephrine were found to have equal efficacy and potency with a median effective concentration ( ec50 ) of 7.1 x 10 ( -7 ) m . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
57,
68
]
} |
placental retention of dexamethasone , a more polar steroid that does not bind to placenta and binds poorly to albumin , was low and there was little difference between transfer from low- and high-protein perfusates . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
111,
118
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
197,
204
]
} |
nahco3 provides the osmotic force for paracellular reabsorption of water and nacl ( bicarbonate-dependent reabsorption ) without additional energy requirement . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
0,
6
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
84,
95
]
} |
tissue blood volume , extracellular space , and extracellular albumin ( va ) were estimated using 51cr-labeled red blood cells , 99mtc-labeled diethylenetriamine pentaacetic acid ( dtpa ) , and 125i-labeled human serum albumin , respectively . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
62,
69
]
} | {
"id": "C0304925",
"name": "human serum",
"pos": [
207,
218
]
} |
after ventilation and ligation of the umbilical cord , concentrations of both pge2-like ( pge ) and pgi in inferior vena caval blood fell , and there was net production of pgi by the newly ventilated lung . | NA | {
"id": "C0012472",
"name": "pge2",
"pos": [
78,
82
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
90,
93
]
} |
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