text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in this study , isozyme patterns for 14 different enzymes were compared for culture strains of leishmania braziliensis , l. hertigi , l. mexicana , l. donovani , l. tropica , and l. adleri . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
16,
23
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
50,
57
]
} |
to test the efficacies of various antidotes to cyanide ( cn ) poisoning , the lethal dose of cyanide in dogs was estimated during constant infusion of potassium cyanide at a rate of 0.1 mg/kg/min . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
47,
54
]
} | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
151,
168
]
} |
in the two contrasting malocclusions , the open bite and the deep overbite , statistically significant differences are shown in the anterior , middle and posterior endocranial regions . | NA | {
"id": "C0024636",
"name": "malocclusions",
"pos": [
23,
36
]
} | {
"id": "C0266061",
"name": "open bite",
"pos": [
43,
52
]
} |
hypertensive patients may present to the emergency department with one of three general problems : high blood pressure due to labile hypertension , chronic hypertension , accelerated hypertension , or a hypertensive emergency ; | NA | {
"id": "C0262534",
"name": "high blood pressure",
"pos": [
99,
118
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
183,
195
]
} |
two doses of triton x-100 and np-40 subunit vaccines prevented the appearance of clinical signs of disease in all vaccinated calves exposed 30 days after the second vaccinal dose to intranasal challenge exposure with cooper strain of ibr virus . | NA | {
"id": "C0887892",
"name": "subunit vaccines",
"pos": [
36,
52
]
} | {
"id": "C0042210",
"name": "vaccinal",
"pos": [
165,
173
]
} |
reporting a case of cutaneous tumor of the back of recent occurrence and rapid increase in a 79-years-old woman , according to crosti 's `` '' reticulosis '' '' , the authors discuss the following points : -- the histiocytic nature of the tumor cells particularly based on immunohistochemical studies ( peroxidase activity , anti-htla serum ) and on electron microscopy with special reference to the multivesicular bodies found in their cytoplasm ; -- the tests for correct identification of the histiocyte ( including electron microscopy , tests for htla and hbla antigens , peroxidatic reaction , acid phosphatase activity , and in vivo or in vitro phagocytosis ) ; -- the out of date character of the concept of malignant `` '' reticulosis '' '' in the hematologica and dermatologic classifications , the recent advances in the knowledge of the nature of the so-called `` '' reticulum '' '' ( or `` '' reticular '' '' ) cell which seems to be a distinct entity derived from the mesenchymal cell ( as the fibroblast ) ; -- the clinical and evolutive characteristics of histiocytic tumors ( no hematologic involvement , slow evolution , high radiosensitivity ) , the difficulties in defining their malignancy and , above all , in finding comparable references in the literature with complete cellular study ; -- the nosologic place of this affection among the group of haematodermas and in the pathology of the mononuclear phagocyte system . | NA | {
"id": "C0016030",
"name": "( as the fi",
"pos": [
998,
1009
]
} | {
"id": "C0007634",
"name": "e",
"pos": [
1,
2
]
} |
the other 9 patients in remission had some pain on pinprick in their neuralgic areas . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
43,
47
]
} | {
"id": "C0027796",
"name": "neuralgic",
"pos": [
69,
78
]
} |
in contrast , of 17 patients with recurrence of td 3 1/2 to 11 years ( median , 6 years ) after treatment , at least 15 had demonstrable pain on pinprick in the neuralgic areas . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
137,
141
]
} | {
"id": "C0027796",
"name": "neuralgic",
"pos": [
161,
170
]
} |
the cytostatic effect of sisomicin and gentamicin , antibiotics from the group of aminoglycosides was studied comparatively with respect to three types of tripsinized cells of chick embryo ( cells of the kidneys , liver and fibroblasts ) . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
25,
34
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
39,
49
]
} |
it was also shown that gentamicin had a lower cytostatic effect on the embryonal cells of the kidneys , liver and fibroblasts as compared to sisomicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
23,
33
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
141,
150
]
} |
the wood 's lamp examination is useful in distinguishing tetracycline-induced yellow nails from other causes of yellow nail pigmentation and may be helpful in determining patient compliance with tetracycline hydrochloride regimens of 1 g or more daily . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
57,
69
]
} | {
"id": "C0546879",
"name": "tetracycline hydrochloride",
"pos": [
195,
221
]
} |
among the particles were silica , two types of asbestos , and kaolinite -- all minerals implicated in the production of lung diseases accompanied by reorganization of connective tissue . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
25,
31
]
} | {
"id": "C0026162",
"name": "minerals",
"pos": [
79,
87
]
} |
ten-day pregnant rats received either distilled drinking water or water containing 0.8 ppm or 2.4 ppm selenium , as sodium selenite or selenomethionine , until the pups were weaned . | NA | {
"id": "C0790233",
"name": "distilled",
"pos": [
38,
47
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
66,
71
]
} |
there was a marked decrease in muscle glutamine and smaller decreases in the basic amino acids in both muscle and plasma . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
38,
47
]
} | {
"id": "C0301714",
"name": "basic",
"pos": [
77,
82
]
} |
muscle : plasma concentration ratios increased for the neutral amino acids , decreased for glutamine and the basic amino acids and were unchanged for the acidic amino acids . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
91,
100
]
} | {
"id": "C0301714",
"name": "basic",
"pos": [
109,
114
]
} |
however input viral dna was degraded both in non permissive cells ( xc ) and permissive cells ( hep-2 ) and the degradation products were found incorporated into cellular dna in the first case or into viral dna in the second case . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
20,
23
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
201,
210
]
} |
a technique for electroforming pure gold margins on the abutment castings of bridge substructures made from gold alloys or base metals alloys has been described . | NA | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
108,
119
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
135,
141
]
} |
the action of l-thyroxine on the incorporation of radioactive choline or cdp-choline into phosphatidylcholine in vitro was explored in liver and brain microsomal fraction and mitochondria obtained from young adult rats . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
62,
69
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
73,
84
]
} |
these data suggest that the coupling between metabolic and ionic events in the islet cells involves feedback mechanisms through which glucose oxidation may be modulated by cationic factors . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
59,
64
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
172,
180
]
} |
a comparison of the kinetics of induction of thiamin- and riboflavin-binding proteins by oestrogen revealed that , beneath an apparent similarity , a clear-cut difference exists between the two vitamin-binding proteins , particularly with regard to hormonal dose-dependent sensitivity of induction and the half-life in circulation . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
20,
28
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
306,
315
]
} |
it was shown that naturally occurring esterified protochlorophyllide and chemically prepared protochlorophyllide methyl ester are not substrates for the enzyme , suggesting an important role for the c-7 carboxylic acid group in binding of the porphyrin to the enzyme . | NA | {
"id": "C0014898",
"name": "ester",
"pos": [
38,
43
]
} | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
203,
218
]
} |
purified cow mammary gland fatty acid synthetase synthesized long-chain unesterified and short-chain esterified fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
27,
37
]
} | {
"id": "C0015691",
"name": "short-chain",
"pos": [
89,
100
]
} |
metabolic pathways were studied by measuring the conversion of radioactive adenine , adenosine , hypoxanthine and guanine into purine ribonucleotides , ribonucleosides , bases and nucleic acid constituents . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
75,
82
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
127,
133
]
} |
preincubation of normal human skin fibroblasts with tunicamycin , which inhibits n-glycosylation of glycoproteins , resulted in a dose-dependent and reversible inhibition of binding and internalization of homologous low-density lipoproteins by the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
35,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
248,
253
]
} |
11 patients with cholelithiasis and choledocholithiasis , respectively , were cholecystectomized with subsequent inspection of the common bile duct . | NA | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
17,
31
]
} | {
"id": "C0701818",
"name": "choledocholithiasis",
"pos": [
36,
55
]
} |
plasma concentrations of noradrenaline and adrenaline and plasma renin activity during extradural blockade in dogs . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} |
thirteen lymphomas consisting of one particular cell type were selected from 135 cases of non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
9,
18
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
90,
113
]
} |
a comparison of the properties of these lymphomas with those of other types of non-hodgkin 's lymphoma and of non-malignant lymphoid cells , shows that the cells of this type of lymphoma ( a ) differ morphologically and/or immunologically from the cells of all other known types of non-hodgkin 's lymphoma and ( b ) resemble centrocytes ( cleaved follicular-centre cells ) of reactive germinal centres . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
40,
49
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
282,
305
]
} |
during the free-choice period the rats on the high-thiamin diet drank only one-fifth as much ethanol as the rats given the optimum diet with 4 mg thiamin hydrochloride/kg . | NA | {
"id": "C0039840",
"name": "thiamin",
"pos": [
51,
58
]
} | {
"id": "C0770309",
"name": "thiamin hydrochloride",
"pos": [
146,
167
]
} |
the levels of the brush-border enzymes sucrase ( sucrose glucohydrolase , ec 3.2.1.48 ) , isomaltase ( oligo-1,6-glucosidase , ec 3.2.1.10 ) , maltases 2 and 3 ( glucoamylase , ec 3.2.1.3 ) , lactase ( beta-galactosidase , ec 3.2.1.23 ) and trehalase ( ec 3.2.1.28 ) and adsorbed pancreatic alpha-amylase ( ec 3.2.1.1 ) have been measured at twenty-one positions along the small intestines of eighty-four pigs of different ages ranging from 3 weeks to 4.5 years . | NA | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
113,
124
]
} | {
"id": "C0002272",
"name": "maltases",
"pos": [
143,
151
]
} |
the levels of the brush-border enzymes sucrase ( sucrose glucohydrolase , ec 3.2.1.48 ) , isomaltase ( oligo-1,6-glucosidase , ec 3.2.1.10 ) , maltases 2 and 3 ( glucoamylase , ec 3.2.1.3 ) , lactase ( beta-galactosidase , ec 3.2.1.23 ) and trehalase ( ec 3.2.1.28 ) and adsorbed pancreatic alpha-amylase ( ec 3.2.1.1 ) have been measured at twenty-one positions along the small intestines of eighty-four pigs of different ages ranging from 3 weeks to 4.5 years . | NA | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
113,
124
]
} | {
"id": "C0015278",
"name": "glucoamylase",
"pos": [
162,
174
]
} |
the levels of the brush-border enzymes sucrase ( sucrose glucohydrolase , ec 3.2.1.48 ) , isomaltase ( oligo-1,6-glucosidase , ec 3.2.1.10 ) , maltases 2 and 3 ( glucoamylase , ec 3.2.1.3 ) , lactase ( beta-galactosidase , ec 3.2.1.23 ) and trehalase ( ec 3.2.1.28 ) and adsorbed pancreatic alpha-amylase ( ec 3.2.1.1 ) have been measured at twenty-one positions along the small intestines of eighty-four pigs of different ages ranging from 3 weeks to 4.5 years . | NA | {
"id": "C0083183",
"name": "lactase",
"pos": [
192,
199
]
} | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
202,
220
]
} |
this is consistent with the theory that n2o inhibits methylcobalamin-dependent methionine synthetase ( ec 2.1.1.13 ) in rat liver and previous observations showing decreased folate incorporation in rats made nutritionally vitamin b12 deficient . | NA | {
"id": "C0065844",
"name": "dependent",
"pos": [
69,
78
]
} | {
"id": "C0042845",
"name": "vitamin b12",
"pos": [
222,
233
]
} |
common salt was fortified with ferric orthophosphate ( 3500 mg/kg ) and sodium hydrogen sulphate ( 5000 mg/kg ) to provide an additional 1 mg elemental fe/g common salt consumed . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
79,
87
]
} | {
"id": "C0013879",
"name": "elemental",
"pos": [
142,
151
]
} |
in contrast , incubation of binary enzyme-dna complexes with apu and [ alpha-32p ] atp results in labeled apupa formation to an extent that is stoichiometric with the amount of enzyme present despite an excess of substrates . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
35,
41
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
177,
183
]
} |
several classes of compounds were identified which failed to unwind pm2 dna , which appeared to have a large dna binding site of at least 4 base pairs and which often showed considerable selectivity of binding to poly [ d ( at ) ] as opposed to poly [ d ( gc ) ] . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
72,
75
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
231,
232
]
} |
in a wheat germ cell-free protein synthetic system these mrnas direct the synthesis of small peptides which can be precipitated by antisera against purified winter flounder antifreeze peptides . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
26,
33
]
} | {
"id": "C0103575",
"name": "antifreeze peptides",
"pos": [
173,
192
]
} |
proteolytic activation of prekallikrein by purified human beta-factor xiia ( mr 28 000 form ) resulted in the formation of kallikrein . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
26,
39
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
123,
133
]
} |
the apparent molecular weight of kallikrein determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the absence of mercaptoethanol was identical with that of prekallikrein ; | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
33,
43
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
177,
190
]
} |
reconstitution of glycophorin into diisostearoyl phosphatidylcholine and dioleoyl phosphatidylcholine liposomes was maximal within a range of temperatures below the phase transition temperatures of dimyristoyl phosphatidylcholine and sphingomyelin but above the phase transition temperatures of diisostearoyl phosphatidylcholine and dioleoyl phosphatidylcholine . | NA | {
"id": "C0012456",
"name": "dimyristoyl phosphatidylcholine",
"pos": [
198,
229
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
342,
361
]
} |
the membrane protein molecular weight distribution is essentially constant as a function of fatty acid composition , but the lipid/protein ratio varies over a 2-fold range when different fatty acid growth supplements are used . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
4,
20
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
131,
138
]
} |
analysis of rna : cdna hybridizations with nuclear polyadenylated rna gave results similar to that observed with polysomal rna , and indicated that nuclear rnas were also present in discrete abundance classes . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
12,
15
]
} | {
"id": "C0035700",
"name": "nuclear rnas",
"pos": [
148,
160
]
} |
15 to 20 % of the neurospora genome is transcribed into various rna species , including messenger and ribosomal rna , in cells growing vegetatively on minimal medium . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
64,
67
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
102,
115
]
} |
the relative synthesis of type i and type iii procollagens was also monitored by isolating these genetically distinct procollagens by deae-cellulose chromatography or by measuring type i and iii collagens by sodium dodecyl sulfate polyacrylamide gel electrophoresis after limited pepsin proteolysis . | NA | {
"id": "C0033235",
"name": "procollagens",
"pos": [
46,
58
]
} | {
"id": "C0009325",
"name": "collagens",
"pos": [
195,
204
]
} |
in the absence of any such hydrogen bonding , the imidazole nucleosides expectedly exhibit nearly 'free ' rotation around the glycosyl bond for the commonly found c ( 3 ' ) endo and c ( 2 ' ) endo sugar ring conformations , thus increasing the probability of anti in equilibrium high-anti in equilibrium syn conformational interconversions as compared to common purine and pyrimidine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
60,
71
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
373,
395
]
} |
the additional attractive interactions between the carboxamide and the phosphate groups favour the syn glycosyl conformation in the 5'-monophosphates of ribavirin as well as pyrazomycin smaller to guanosine 5'-monophosphate whereas the anti conformation is strongly favoured for the 5'-nucleotides of tetrazole and showdomycin similar to other common purine and pyrimidine nucleotides . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
286,
297
]
} | {
"id": "C0034288",
"name": "pyrimidine nucleotides",
"pos": [
362,
384
]
} |
the conformational properties of five-membered base ring nucleosides have a strong resemblance to purine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
57,
68
]
} | {
"id": "C0034136",
"name": "purine",
"pos": [
98,
104
]
} |
isotherms that describe the binding of anthracycline antibiotics ( including daunorubicin and doxorubicin ( adriamycin ) ) to calf thymus dna and chromatin have been obtained by means of fluorescence measurements . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
77,
89
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
94,
105
]
} |
whereas at low salt concentration the binding parameters for the doxorubicin-chromatin interaction are similar to those expected by neutralization of the phosphate groups by histones , modifications of the dna structure in chromatin are invoked to account for the reduction and heterogeneity of daunorubicin binding sites . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
65,
76
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
295,
307
]
} |
at blastula stage , a period of rapid cell proliferation , similar studies of dna polymerase subcellular localization using two different methods of nuclear isolation indicate that the dna polymerase beta remains largely cytoplasmic while the alpha enzyme is found to be predominantly nuclear . | NA | {
"id": "C0012892",
"name": "dna polymerase",
"pos": [
78,
92
]
} | {
"id": "C0525039",
"name": "dna polymerase beta",
"pos": [
185,
204
]
} |
with reconstituted chromatin , however , neither the sedimentation profile , nor the relative content of ribosomal and satellite dna sequences were recovered , thus indicating that reconstitution did not yield nucleoprotein structurally similar to native chromatin . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
210,
223
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
255,
264
]
} |
during different steady state growth conditions in escherichia coli the level of the three trna-modifying enzymes , the trna ( m5urd ) - , trna ( m1guo ) - and trna ( mam5s2urd ) methyltransferase and of five aminoacyl-trna synthetases , the leucyl- , valyl- , isoleucyl- , arginyl- and threonyl-trna-synthetase , has been determined . | NA | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
209,
235
]
} | {
"id": "C0040011",
"name": "threonyl-trna-synthetase",
"pos": [
287,
311
]
} |
however , methylene blue , 2,6-dichlorophenolindophenol , k3fe ( cn ) 6 , menadione , riboflavin , fmn and molecular oxygen served as alternate electron acceptors with varying degrees of efficiency . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
86,
96
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
99,
102
]
} |
clofibrate feeding doubled the concentration of hepatic long-chain acyl ( - ) carnitine , mitochondrial carnitine , and the rate of mitochondrial carnitine-acylcarnitine translocase reaction , and enhanced acetoacetate production in liver homogenates as well as mitochondrial oxidation of palmitoylcarnitine in the presence of malonate . | NA | {
"id": "C0007258",
"name": "carnitine",
"pos": [
78,
87
]
} | {
"id": "C0030242",
"name": "palmitoylcarnitine",
"pos": [
289,
307
]
} |
butyrate incorporation from butyryl-coa in the presence of palmitoyl-coa was favoured by a high concentration of butyryl-coa and by the presence of a long-chain acyl-coa binding protein such as bovine serum albumin . | NA | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
59,
72
]
} | {
"id": "C0001374",
"name": "long-chain acyl-coa",
"pos": [
150,
169
]
} |
ehrlich ascites cells and monolayers of l-m cell fibroblasts were grown in medium containing either long-chain fatty alcohols or alkylglycerols . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
16,
21
]
} | {
"id": "C0016030",
"name": "cell fibroblasts",
"pos": [
44,
60
]
} |
the cholesteryl ester formed during in vitro incubation of incubations of microsomes with either [ 1-14c ] -oleoyl coa or [ 7-3h ] cholesterol was localized in the same region of the density gradient as acyl-coa : cholesterol o-acyltransferase . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
4,
21
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
214,
225
]
} |
9l:9d , 79:21 and 13l:13d , 9- and 13-hydroxyoctadecadienoates which had largely lost the tritium label ( 6 % and 7 % retention of tritium relative to precursor , respectively ) showing that the hydrogen which is removed from c-11 during the conversion has the l ( pro-s ) configuration . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
90,
97
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
195,
203
]
} |
the observed order of potency for adrenergic agonists in stimulating prostatic adenylate cyclase activity was isoproterenol greater than epinephrine approximately or equal to salbutamol greater than norepinephrine , indicating properties characteristic of beta-2-adrenergic receptor-sensitive adenylate cyclase systems . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
137,
148
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
199,
213
]
} |
an initial incubation of the gland with isoproterenol or dopamine resulted in a decrease in maximal enzyme activation by catecholamine , either isoproterenol or dopamine , with no change in hormone affinity . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
121,
134
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
144,
157
]
} |
sarcoplasmic reticulum membrane phosphorylation , mediated by either endogenous cyclic amp-independent or exogenous cyclic amp-dependent protein kinase , occurred on a 100 000 dalton protein and both enzyme activities resulted in enhanced calcium uptake and ca2+-dependent atpase ( atp phosphohydrolase , ec 3.6.1.3 ) , in a manner similar to cardiac microsomal preparations . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
258,
261
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
282,
302
]
} |
50 % decrease in 125i-labeled epidermal growth factor binding was observed also with imr-90 fibroblasts upon 6 h treatment with tunicamycin , although these cells were less sensitive to inhibition by tunicamycin of glycosylation and protein synthesis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
92,
103
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
157,
162
]
} |
the component confers gpp ( nh ) p , fluoride , and gtp stimulation of adenylate cyclase along a single reconstitution curve . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
22,
34
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
52,
55
]
} |
in contrast , cyclic amp accumulation in response to epinephrine or norepinephrine was not potentiated by either methyl xanthines or by adenosine deaminase . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
53,
64
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
68,
82
]
} |
blocking the alpha adrenergic activity of norepinephrine and epinephrine with phentolamine established synergism between these catecholamines and methyl xanthines and adenosine deaminase . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} |
the activity of the particulate phosphodiesterase was not influenced by norepinephrine suggesting that the lack of synergism between the catecholamines norepinephrine and epinephrine and methyl xanthines is unrelated to this enzyme . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
72,
86
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
171,
182
]
} |
the photoinduced volume change was practically the same in all cases studied ( equal ionic constitutions inside and outside of vesicles ; in the presence of penetrating anion scn- ; under ionic gradients on vesicle membranes ; in the presence of ionophores which induce the permeability for k+ and h+ ) and corresponds to the appearance of no more than one ion inside the vesicle under bleaching of one rhodopsin molecule . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
169,
174
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
357,
360
]
} |
the content of adrenaline , noradrenaline , acth , cortisol and insulin in the blood and excretion of catecholamines with urine were studied in horses after physical and emotional exposures . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
28,
41
]
} |
concentrations of testosterone , 5d-dihydrotestosterone , hydrocortisone and precursors ( progesterone , pregnenolone , 17-hydroxyprogesterone , 17-hydroxypregnenolone and 11-deoxycortisol ) were determined in peripheral blood plasma by radioimmunoassay . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
90,
102
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
120,
142
]
} |
concentrations of testosterone , 5d-dihydrotestosterone , hydrocortisone and precursors ( progesterone , pregnenolone , 17-hydroxyprogesterone , 17-hydroxypregnenolone and 11-deoxycortisol ) were determined in peripheral blood plasma by radioimmunoassay . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
105,
117
]
} | {
"id": "C0376260",
"name": "17-hydroxypregnenolone",
"pos": [
145,
167
]
} |
the plasma profile of 20 alpha-dihydroprogesterone most closely approximated that of progesterone , although the range of maximal values was lower ( 7.11-16.06 nmol/l ; 228-514 ng/100 ml ) . | NA | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
22,
50
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
85,
97
]
} |
it is concluded that the increases in circulating concentrations of progesterone and the biologically active metabolite 20 alpha-dihydroprogesterone , and the duration of these increases , were sufficient to modulate the biochemistry of responsive tissues . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
68,
80
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
120,
122
]
} |
the present report compares the synaptosomal release of [ 3h ] dopamine , continuously forming from [ 3h ] dopa , with that of [ 14c ] dopamine , forming from [ 14c ] tyrosine as a marker of dopaminergic nerve endings . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
63,
71
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
191,
203
]
} |
in addition , the intravenous dose of d-amphetamine sulfate which was required to reduce the spontaneous firing rate of these cells by at least 50 % ( threshold dose ) was not modified by amphetamine pretreatment . | NA | {
"id": "C0282051",
"name": "amphetamine sulfate",
"pos": [
40,
59
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
188,
199
]
} |
the glutamyl-trna synthetase purified 300-fold from calf brain is associated with other aminoacyl-trna synthetases in a complex whose molecular weight is about 2,000,000 . | NA | {
"id": "C0017811",
"name": "glutamyl-trna synthetase",
"pos": [
4,
28
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
88,
114
]
} |
if we assume that mepp frequencies are an index of the concentration of the divalent cations at some critical site in the nerve terminal , then the fall in mepp frequency reflects the clearing of the divalent metal cation from the critical region . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
76,
92
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
215,
221
]
} |
fifteen patients with multiple myeloma were treated with sodium fluoride ( 50 mg twice daily ) plus calcium carbonate ( 1 g four times daily ) or with the same fluoride-calcium dosage plus vitamin d ( 50,000 u twice weekly ) . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
57,
72
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
160,
168
]
} |
forty-three patients with cutaneous t-cell lymphomas ( mycosis fungoides and the sezary syndrome ) underwent routine staging procedures to assess extent of disease prior to therapy . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphomas",
"pos": [
26,
52
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
81,
96
]
} |
antigenic similarity between plasma membrane proteins of fetal hamster cells and simian virus 40 tumor surface antigens . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
0,
9
]
} | {
"id": "C0003335",
"name": "tumor",
"pos": [
97,
102
]
} |
the studies provide strong confirmation of an earlier proposal that nitrenium ion contributors of delocalized aromatic cations from 3-acyloxypurines , rather than radical intermediates , are the agents responsible for the oxidizing reactivity of these esters . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
36,
39
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
119,
126
]
} |
specific anti-rat embryonic hemoglobin serum was prepared by immunizing a rabbit with hemoglobin from a 15- or 16-day-old wistar rat fetus and absorbing with adult rat liver hemogenate and red blood cells . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
28,
38
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
185,
186
]
} |
this study compares the cellular or transmembrane potential of hepatocytes and fibroblasts in both normal and tumor cells . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
24,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
79,
90
]
} |
high-impedance micropipets were used to record intracellularly in vivo in buffalo rat hepatocytes and morris 7777 hepatoma cells , as well as a/j mouse corneal fibroblasts and poorly differentiated fibrosarcoma cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
160,
171
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} |
anft-induced ornithine decarboxylase activity was principally localized in the bladder epithelium and was inhibited in a linear dose-response relationship by the synthetic retinoid , 13-cis-retinoic acid . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
172,
180
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
183,
203
]
} |
normal human diploid fibroblasts ( wi-38 cells ) were used in culture at confluency , when fewer than 1 % of the cells were synthesizing dna . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
21,
32
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
113,
118
]
} |
the diagnosis of variant angina should be considered when rest angina occurs after bypass surgery , particularly if exertional angina is absent and grafts are patent . | NA | {
"id": "C0002963",
"name": "variant angina",
"pos": [
17,
31
]
} | {
"id": "C0002965",
"name": "rest angina",
"pos": [
58,
69
]
} |
twenty-four-hour urinary epinephrine ( e ) and norepinephrine ( ne ) were greater than normal ( e + ne excretion , 44 +/- 2 vs 29.5 microgram/g creatinine , p less than 0.001 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
25,
36
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
152,
154
]
} |
we conclude that ventricular tachycardia associated with ischemic heart disease originates near the endocardial surface of the left ventricle along the border of the infarction and that epicardial mapping alone is insufficient to identify the site of origin of these tachycardias . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
17,
40
]
} | {
"id": "C0039231",
"name": "tachycardias",
"pos": [
267,
279
]
} |
the phospholipid content of this fraction , known as lamellar body phospholipid , provides an indication of fetal lung maturity ( ann . | NA | {
"id": "C0771648",
"name": "phospholipid",
"pos": [
4,
16
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
67,
79
]
} |
the results show significantly higher activities in the patients for alpha-l-fucosidase ( p less than 0.001 ) and for beta-n-acetylglucosaminidase ( p less than 0.1 , p less than 0.001 and p less than 0.05 , respectively ) , and smaller or not significantly greater values for the other glycosidases . | NA | {
"id": "C0016787",
"name": "alpha-l-fucosidase",
"pos": [
69,
87
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
287,
299
]
} |
measurements of uptake in vivo of 3h-proline into 3h-hydroxyproline demonstrate that cartilage surfaces in rabbit knees with surgically induced osteoarthrosis ( up to 3 months after operation ) incorporated 2 to 5 times more activity into collagen than cartilage of control knees . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
37,
44
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
53,
67
]
} |
the diagnosis of intussusception of the appendiceal stump in the postoperative period is difficult because of the nonspecificity of symptoms , the paucity of physical findings , and the intermittent nature of the partial bowel obstruction . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
17,
32
]
} | {
"id": "C0021843",
"name": "of",
"pos": [
206,
208
]
} |
a 3-year clinical trial into the effect of fluoride content and toothpaste abrasivity on the caries inhibitory properties of a dentifrice . | NA | {
"id": "C0040462",
"name": "toothpaste",
"pos": [
64,
74
]
} | {
"id": "C0011427",
"name": "dentifrice",
"pos": [
127,
137
]
} |
in all the patients with craniosynostosis , calvaria bone scanning revealed the pathological sutures as areas of diminished or absent radionuclide accumulation , while a normal isotope uptake was observed at all the cranial sutures in the children with microcrania . | NA | {
"id": "C0034595",
"name": "radionuclide",
"pos": [
134,
146
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
177,
184
]
} |
since prior studies of cricket proteins have indicated that somatic histones persist during the stages when nucleosome structure disappears , the observations imply that the histones which are organized in nucleosomes during early stages must become incorporated into different kinds of nucleoprotein complexes during succeeding stages of spermiogenesis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
31,
39
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
287,
300
]
} |
in our case complete achlorhydria to pentagastrin was associated with low serum and antral gastrin concentrations . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
37,
49
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
91,
98
]
} |
of 17 patients with pancreatic juice ggt concentrations greater than 52 iu/liter , eleven had definite pancreatic disease ( seven pancreatic cancer , four chronic pancreatitis ) and , in the remaining six , pancreatitis was possible although not proven . | NA | {
"id": "C0030286",
"name": "pancreatic disease",
"pos": [
103,
121
]
} | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
207,
219
]
} |
immunochemical determinants unique to human chorionic gonadotropin : importance of sialic acid for antisera generated to the human chorionic gonadotropin beta-subunit cooh-terminal peptide . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
38,
66
]
} | {
"id": "C0106132",
"name": "human chorionic gonadotropin",
"pos": [
125,
153
]
} |
equine chorionic gonadotropin ( ecg ) secreted by horse trophoblast cells cultivated in vitro was isolated and its chemical , immunochemical , and biological characteristics were compared to those of the gonadotropin secreted in vivo and isolated from pms . | NA | {
"id": "C0018064",
"name": "equine chorionic gonadotropin",
"pos": [
0,
29
]
} | {
"id": "C0018061",
"name": "gonadotropin",
"pos": [
204,
216
]
} |
these studies revealed a small population ( mean +/- sem , 0.087 +/- 0.017 pmol/uterus ) of unfilled estrogen-binding sites in the uterine nuclear fraction from untreated immature rats , which bound [ 3h ] estradiol in the absence of added cytoplasmic receptor . | NA | {
"id": "C0034804",
"name": "estrogen-binding sites",
"pos": [
101,
123
]
} | {
"id": "C0034803",
"name": "estradiol",
"pos": [
206,
215
]
} |
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