text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
integrated concentration of epinephrine and norepinephrine in normal subjects and in patients with mild essential hypertension . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
28,
39
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} |
a portable nonthrombogenic blood withdrawal system , permitting normal activity and sleep , was used for obtaining the 24-h integrated concentration ( ic ) of epinephrine ( e ) and norepinephrine ( ne ) in 46 normal control subjects , 30 patients with mild essential hypertension , and 1 patient with pheochromocytoma . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
159,
170
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
181,
195
]
} |
the volatile fatty acids , alcohols , nonvolatile fatty acids , and ketones produced by anaerobes can be separated and identified by using a single type of gas-chromatographic column . | NA | {
"id": "C0015691",
"name": "volatile fatty acids",
"pos": [
4,
24
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
50,
61
]
} |
to assess the full potential of computed tomography ( ct ) in the investigation and management of malignant lymphomas , a series of 160 patients with both hodgkin 's and non-hodgkin 's lymphomas was reviewed . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
98,
117
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
170,
194
]
} |
it has been concluded that the variously named verrucous lesions in the literature ( epithelioma cuniculatum , florid papillomatosis , giant cutaneous papilloma and papillomatosis cutis carcinoides ) , as well as our five cases represent a verrucous carcinoma which is a particular type of squamous cell carcinoma . | NA | {
"id": "C0206706",
"name": "verrucous carcinoma",
"pos": [
240,
259
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
304,
313
]
} |
fifteen male holstein calves were fed diets containing .25 ( control ) , .7 , or 1.15 % magnesium ( from supplemental magnesium oxide ) for 28 days . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
88,
97
]
} | {
"id": "C0024477",
"name": "magnesium oxide",
"pos": [
118,
133
]
} |
surfaces remineralized 25 hours in 0.4 mm naf ( 8 ppm f- ) dissolved slower in acid or in edta than those remineralized in the absence of f- . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
42,
45
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
138,
139
]
} |
fluoride concentration of enamel surfaces treated with 50 % h3po4 , together with high naf contents or etched with 50 % h3po4 followed by application with a water solution of high naf content , was examined . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
0,
8
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
180,
183
]
} |
utilization of intravenous dihydroxypropyl theophylline ( dyphylline ) in an aminophylline-sensitive patient , and its pharmacokinetic comparison with theophylline . | NA | {
"id": "C0013360",
"name": "dyphylline",
"pos": [
58,
68
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
151,
163
]
} |
the pharmacokinetics and urinary excretion of intravenously administered 7- ( 2,3-dihydroxypropyl ) theophylline ( dyphylline ) , were studied in a 37-yr-old asthmatic woman with ethylene diamine sensitivity who manifested intolerance to intravenous aminophylline on three separate occasions . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
100,
112
]
} | {
"id": "C0013360",
"name": "dyphylline",
"pos": [
115,
125
]
} |
following exercise there was an increase in plasma catecholamines , a significant leukocytosis , and granulocytes from the immediate postexercise period responded less well to isoproterenol . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
51,
65
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
176,
189
]
} |
certain macrolide antibiotics , such as troleandomycin ( tao ) , oleandomycin , and erythromycin estolate ( ilosone ) , can lower the maintenance dose of glucocorticoids required by severely asthmatic patients . | NA | {
"id": "C0041165",
"name": "tao",
"pos": [
57,
60
]
} | {
"id": "C0028923",
"name": "oleandomycin",
"pos": [
65,
77
]
} |
a prompt increase in the levels of blood glucose , serum insulin and serum glucagon was observed , but the glucose and glucagon peaks were significantly higher in the aged nondiabetic and diabetic subjects . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
9,
11
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
107,
114
]
} |
prostaglandin ( pg ) e and 19-oh pge , now considered to be the most important of the human seminal prostaglandins , were assayed in infertile and normal men . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
33,
36
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
100,
114
]
} |
in this review the question of obesity in the pre-school child has been examined in three areas of interest : first , the extent of our knowledge of food intake and its relationship to growth in the young child ; | NA | {
"id": "C0008059",
"name": "child",
"pos": [
57,
62
]
} | {
"id": "C0728836",
"name": "young child",
"pos": [
199,
210
]
} |
other component chains of secretory iga ( secretory component , light and j chains ) were not susceptible . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
26,
39
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
42,
61
]
} |
this protein , designated dna-binding protein-2 ( dbp-2 ) , is recognized by antisera directed against both factor b and its activated form , fragment bb . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
26,
45
]
} |
the potential biologic significance of these proteins is suggested by their potency : as little as 1.2 ng of viral protein inhibited ( p less than 0.02 ) macrophage accumulation when injected at a site distant to the inflammatory reaction . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
45,
53
]
} | {
"id": "C0042736",
"name": "viral protein",
"pos": [
109,
122
]
} |
since human myeloid progenitor cells ( cfu-c ) express hla antigens and beta 2 mu is a known molecular component of hla antigens , we wondered whether the reported effect of anti-beta 2 mu heteroantisera on in vitro granulopoiesis might result from cytotoxicity to cfu-c rather than from cross-reactivity with csa . | NA | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
55,
67
]
} | {
"id": "C0019728",
"name": "a",
"pos": [
312,
313
]
} |
[ 3h ] pyridoxine phosphate is displaced from the matrix-attached antibodies by pyridoxine phosphate , pyridoxamine phosphate , and pyridoxal phosphate , but is not displaced to any significant extent by pyridoxine , pyridoxamine , pyridoxal , or 5'-deoxypyridoxal . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
132,
151
]
} | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
204,
214
]
} |
the effect of high antigen density on solid-phase radioimmunoassays for antibody regardless of immunoglobulin class . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
72,
80
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
95,
115
]
} |
trypsin digestion ( 2 mg/ml , 30 min at 37 degrees c ) proved to be most effective for disrupting hbsag-ics formed at equivalence as well as in excess of antigen or antibody . | NA | {
"id": "C0003313",
"name": "hbsag-ics",
"pos": [
98,
107
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
165,
173
]
} |
thus nine out of twenty-one human tumour cell lines and sv40-transformed fibroblasts differed from autologous lymphoblastoid cells or fibroblasts in their reactivity with hla alloantisera . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
125,
130
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
134,
145
]
} |
comparison of the [ 35s ] mucopolysaccharides extracted after in vitro incubation of skin biopsy specimens from nonlesional and lesional sites of a patient with mastocytosis showed that lesional sites incorporated sulfate into heparin . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
26,
45
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
227,
234
]
} |
approximately one-half of the [ 35s ] mucopolysaccharides obtained in the 3 sequential extracts of lesional tissue was resistant to degradation by chondroitinase abc as determined by gel filtration before and after enzyme treatment , indicating the presence of sulfated mucopolysaccharides in addition to chondroitin and dermatan sulfates . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
38,
57
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
305,
316
]
} |
approximately one-half of the [ 35s ] mucopolysaccharides obtained in the 3 sequential extracts of lesional tissue was resistant to degradation by chondroitinase abc as determined by gel filtration before and after enzyme treatment , indicating the presence of sulfated mucopolysaccharides in addition to chondroitin and dermatan sulfates . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
147,
158
]
} | {
"id": "C0011602",
"name": "dermatan sulfates",
"pos": [
321,
338
]
} |
heparinase treatment of the chondroitinase abc-resistant [ 35s ] mucopolysaccharides followed by gel filtration revealed an equal distribution of label between heparin and heparinase-resistant material presumed to be heparan sulfate . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
65,
84
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
172,
179
]
} |
heparinase treatment of the chondroitinase abc-resistant [ 35s ] mucopolysaccharides followed by gel filtration revealed an equal distribution of label between heparin and heparinase-resistant material presumed to be heparan sulfate . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
65,
84
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
217,
232
]
} |
since linoleic acid is a precursor of prostaglandins , correction of the defect in barrier function may either reflect a prostaglandin-mediated return toward normal epidermal differentiation , or , instead , a direct effect of linoleic acid . | NA | {
"id": "C0033555",
"name": "a",
"pos": [
15,
16
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
121,
134
]
} |
isoproterenol ( 2 microgram/ml ) produced parallel increases in glycerol and free fatty acid release , and in tissue cyclic amp levels , suggesting that cyclic amp mediates the action of the catecholamine on triglyceride mobilization . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
0,
13
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
191,
204
]
} |
in addition , they contain large amounts of phospholipid , cholesterol , and cholesteryl ester and are the sole site of bis ( monoacylglycero ) phosphate and the enzyme which catalyzes its synthesis from phosphatidylglycerol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
59,
70
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
77,
94
]
} |
choline was the only water-soluble base present in the lower r ( f ) sphingomyelin while ethanolamine was prevalent in the higher r ( f ) component . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
65,
66
]
} | {
"id": "C0016330",
"name": "f",
"pos": [
134,
135
]
} |
four of the eight antibodies react with conventional antisera to the previously described a/j anti-arsonate cross-reactive idiotype ( cri ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
18,
28
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
53,
61
]
} |
inhibition studies of type-specific immune sera with pep m24 and peptides derived therefrom indicated that the m protein molecule contained multiple distinct as well as identical type-specific antigenic determinants that are unequally distributed among the seven derived peptide fragments . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
65,
73
]
} | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
271,
288
]
} |
igd ( + ) and igd ( - ) memory cells carry igg receptors and give rise to igg responses with identical isotype representation in adoptive recipients . | NA | {
"id": "C0020843",
"name": "igd",
"pos": [
0,
3
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
103,
110
]
} |
these hybridoma antibodies were derived by fusing mutant mouse myeloma cells to spleen cells from lewis rats immunized with allogeneic brown norway cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
71,
76
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
124,
134
]
} |
it could be excluded that the antisera contained contaminating antibodies against tnp , tnp-neoantigenic determinants ( nad ) , or processed ctl-receptor-bound tnp-nad , thus demonstrating specificity for determinants on t cell receptors of akraakr-tnp ctl . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
30,
38
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
63,
73
]
} |
two-dimensional electrophoretic analysis of ribosomal proteins complemented by autoradiography revealed that ccl4 stimulated the phosphorylation of only a single protein ( s6 ) in the 40 s subunit . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
44,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
162,
169
]
} |
the defect in the nim mutant is complemented by the e. coli f ' element , f'148 . | NA | {
"id": "C0016330",
"name": "f",
"pos": [
6,
7
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
74,
75
]
} |
increased pgf2 alpha levels were found in patients with epilepsy when samples were collected within a few days after a convulsion . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
56,
64
]
} | {
"id": "C0036572",
"name": "convulsion",
"pos": [
119,
129
]
} |
statistical analysis demonstrated that ferruginous bodies found in the sputa were significantly related to radiographic findings of interstitial pulmonary disease and pleural fibrosis and to spirometric findings of restrictive lung disease . | NA | {
"id": "C0206062",
"name": "interstitial pulmonary",
"pos": [
132,
154
]
} | {
"id": "C0024115",
"name": "of",
"pos": [
212,
214
]
} |
the recovery of gram-negative enteric rods in the tta aspirate provided guidance in adding an aminoglycoside to the antimicrobial therapy in 35 children ( 47 % ) . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
94,
108
]
} | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
116,
129
]
} |
to study the delivery of oxygen to the cerebral tissue during metabolic acidosis and its therapy with bicarbonate ( nahco3 ) , oxygen partial pressure of the cisternal fluid was measured in 12 experiments of hcl-induced acidemia and eight experiments of diabetic ketoacidosis in 16 unanesthetized dogs . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
102,
113
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
116,
122
]
} |
polylysines of 7-371 lysine residues inhibited pepsin over the ph range 3.6-5.0 in a system using azocoll as substrate . | NA | {
"id": "C0032518",
"name": "polylysines",
"pos": [
0,
11
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
21,
27
]
} |
an almost 1:1 molar ratio with pepsin gave maximum inhibition for a polylysine containing 59 lysine residues but increase in polylysine molecular size beyond this size was not accompanied by increase in activity on a weight basis although the polylysine : pepsin molar ratio for maximum inhibition decreased and inhibition mechanism varied . | NA | {
"id": "C0024337",
"name": "lysine",
"pos": [
72,
78
]
} | {
"id": "C0032518",
"name": "polylysine",
"pos": [
243,
253
]
} |
polylysines of 59 and 158 lysine residues which were intermediate in the series were non-competitive inhibitors , whilst polylysines of greater and smaller molecular size were competitive inhibitors , although only the smallest inhibitory polylysine , containing 7 lysine residues , was a pure competitive inhibitor . | NA | {
"id": "C0032518",
"name": "polylysine",
"pos": [
0,
10
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
265,
271
]
} |
incubation of human blood with 0.3 mm sodium nitroprusside ( snp ) or 1 mm potassium cyanide ( kcn ) for 180 min produced a 600-fold increase in red cell cyanide concentration , a 4 % decrease in oxygen capacity and a 6 % increase in oxygen affinity . | NA | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
75,
92
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
154,
161
]
} |
the in vitro observations could be explained by cyanide either combining directly with the haemoglobin or encouraging its spontaneous oxidation to methaemoglobin during the incubation . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
91,
102
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
147,
161
]
} |
differences in distribution of cyanide between red cell and plasma following incubation with snp or kcn and the initial lag phase in accumulation of cyanide in the red cell with snp provide further evidence that nitroprusside breaks down principally within the red cell . | NA | {
"id": "C0037533",
"name": "snp",
"pos": [
93,
96
]
} | {
"id": "C0028193",
"name": "nitroprusside",
"pos": [
212,
225
]
} |
in contrast , the ion selectivity of ii was dependent on the electrolyte concentrations since the delta ( deltav ) value between calcium chloride and sodium chloride was maximal ( 130 mv ) on 1000 meq and negligible on 500- and 2000-meq salt solutions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
18,
21
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
61,
72
]
} |
since the ion selectivity was manifested most at both high electrolyte and high lecithin concentrations , the ionophore probably prefers the low dielectric constant of neutral lipid membranes to complex with the selected cation . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
10,
13
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
221,
227
]
} |
the release of digoxin and its simultaneous conversion to digoxigenin bisdigitoxoside , digoxigenin monodigitoxoside , and digoxigenin in a usp dissolution test medium were followed by high-pressure liquid chromatography . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
15,
22
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
123,
134
]
} |
death in ventricular fibrillation was induced consistently in desoxycorticosterone acetate-pretreated rats by the beta-adrenergic agonist isoproterenol but not by norepinephrine or epinephrine , both of which possess alpha- as well as beta-adrenergic activity . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
163,
177
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
181,
192
]
} |
with the addition of aminophylline , both norepinephrine and epinephrine produced death in ventricular fibrillation , and the existing cardiotoxicity of isoproterenol was potentiated . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} |
similarly , in the presence of phenoxylbenzamine , doses of norepinephrine and epinephrine that had been well tolerated became lethal . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
79,
90
]
} |
internventions that favor beta-adrenergic preponderance , either by enhancing beta-effects or by blocking protective alpha-adrenergic activation , apparently increase the arrhythmogenic propensity of norepinephrine and epinephrine in steroid-pretreated rats . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
200,
214
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
219,
230
]
} |
glycoproteins of different molecular weight , but immunologically related to the major hamster membrane glycoproteins , have been detected at the surface of both rat and mouse fibroblasts . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
0,
13
]
} | {
"id": "C0025248",
"name": "membrane glycoproteins",
"pos": [
95,
117
]
} |
segregation of the two extra rnas was carried out by coinfection of cells with a von magnus particle and infectious virions . | NA | {
"id": "C0275524",
"name": "coinfection",
"pos": [
53,
64
]
} | {
"id": "C0009450",
"name": "infectious",
"pos": [
105,
115
]
} |
previous studies indicated that ( i ) t4 gene s product ( gps ) protects infected cells from superinfection lysis from without , ( ii ) the absence of gps in infected cells also leads to lysis from within even when t4 e lysozyme is absent , ( iii ) t4 gene 5 product ( gp5 ) , a polypeptide of the virion baseplate , may be responsible for inducing lysis from without , and ( iv ) altered gp5 of the t4 mutant 5ts1 can replace e lysozyme to cause lysis from within . | NA | {
"id": "C0033684",
"name": "gene",
"pos": [
41,
45
]
} | {
"id": "C1564139",
"name": "gp5",
"pos": [
389,
392
]
} |
semliki forest virus ( sfv ) -infected bhk-21 , vero , and hela cells incorporated [ 3h ] uridine into 42s and 26s plus-strand rna and into viral minus-strand rna ( complementary to the 42s virion rna ) early in the infectious cycle . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
127,
130
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
140,
145
]
} |
separation of neutralizing antibodies from hemagglutination inhibition ( hai ) antibodies to polyoma in antisera directed against the histone region of polyacrylamide gels was done by using a polyoma capsid affinity column . | NA | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
14,
37
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
79,
89
]
} |
separation of neutralizing antibodies from hemagglutination inhibition ( hai ) antibodies to polyoma in antisera directed against the histone region of polyacrylamide gels was done by using a polyoma capsid affinity column . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
104,
112
]
} |
during a chase , the dna with a higher sedimentation coefficient in neutral sucrose and a lower sedimentation rate in alkaline sucrose than that of viral phi 29 dna was converted into mature dna . | NA | {
"id": "C0012939",
"name": "viral",
"pos": [
148,
153
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
191,
194
]
} |
that the viral dna is integrated into different host dna sequences in each cell line studied ; | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
9,
18
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
53,
56
]
} |
it is concluded that the thymine and alpha-putrescinylthymine in phi w-14 dna are formed from hydroxymethyluracil at the polynucleotide level and that an intermediate in one or both of these conversions is degraded to uracil by acid hydrolysis . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
25,
32
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
218,
224
]
} |
restriction enzyme analysis of the 5.3 x 10 ( 6 ) -dalton unintegrated mav viral dnas and their integrated proviruses suggests that the dnas have a direct terminal redundancy of approximately 0.3 megadaltons and integrate colinearly with respect to the unintegrated linear dna . | NA | {
"id": "C0012939",
"name": "viral dnas",
"pos": [
75,
85
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
273,
276
]
} |
concatemeric phage dna was synthesized but was not packaged into the phage head , resulting in an accumulation of dna species shorter in size than the phage genome , concomitant with an accumulation of phage head-related structures . | NA | {
"id": "C1257941",
"name": "concatemeric",
"pos": [
0,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
114,
117
]
} |
since the gene 2 product acts as a specific inhibitor of e. coli rna polymerase by preventing the enzyme from binding t7 dna , uninhibited e. coli rna polymerase in gene 2 mutant phage-infected cells interacts with concatemeric t7 dna and perturbs proper dna processing unless another inhibitor of the enzyme ( rifampin ) was added . | NA | {
"id": "C1257941",
"name": "concatemeric",
"pos": [
215,
227
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
255,
258
]
} |
treatment of human fibroblasts with interferon induces the synthesis of several proteins , as detected by incorporation of [ 35s ] methionine followed by analysis of cell extracts by polyacrylamide gel electrophoresis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
166,
170
]
} |
labeling for 2-h periods at varying time intervals after the addition of interferon revealed that the synthesis of these proteins was induced within a few hours , peaked at different time intervals , and was soon followed by a marked decline , suggesting that the mrna 's for these proteins have short half-lives . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
102,
111
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
282,
290
]
} |
both 9- ( 2-hydroxy-ethoxymethyl ) guanine ( acyclovir ) and phosphonoacetic acid inhibit the appearance of one intermediate protein and at least three late proteins . | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
35,
42
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
45,
54
]
} |
the effect of acyclovir [ 9- ( 2-hydroxyethoxymethyl ) guanine ] on epstein-barr virus ( ebv ) dna replication in the lymphoblastoid cell lines p3hr-1 and raji is reported . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
14,
23
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
55,
62
]
} |
the ebv dna remaining in p3hr-1 cells after treatment with 100 microm acyclovir ( approximately 14 genomes per cell ) had the properties of covalently closed circular dna with an average molecular weight of 108 x 10 ( 6 ) , as determined by contour length measurements . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
8,
11
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
158,
170
]
} |
presented is a clinical characterization of chronic wasting disease and pathologic evidence supporting the conclusion that the disease is a specific spontaneously occurring form of spongiform encephalopathy . | NA | {
"id": "C1135993",
"name": "chronic wasting disease",
"pos": [
44,
67
]
} | {
"id": "C0162534",
"name": "spongiform",
"pos": [
181,
191
]
} |
to study the pathophysiology and the pathogenesis of hypertensive cardiac diseases such as cardiac hypertrophy and ischemic heart diseases , and to determine the relationship between these cardiopathies , spontaneously hypertensive rats ( shr ) and stroke-prone shr ( shrsp ) were used as models . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
9,
12
]
} | {
"id": "C0151744",
"name": "ischemic heart diseases",
"pos": [
115,
138
]
} |
we investigated the effects of four cysteine derivatives on 12 antibiotics , ampicillin ( abpc ) , amoxicillin ( ampc ) , sulbenicillin ( sbpc ) , cefazolin ( cez ) , cephalexin ( cex ) , cephalothin ( cet ) , oxytetracycline ( otc ) , doxycycline ( dotc ) , minocycline ( mino ) , erythromycin ( em ) , ribostamycin ( vsm ) and lincomycin ( lcm ) , widely used clinically in vitro with the minimum inhibitory concentration ( mic ) obtained by the liquid dilution method as an index . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
77,
87
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
99,
110
]
} |
l-cysteine , acetylcysteine , ethylcysteine and mecysteine lowered the potencies of almost all of the antibiotics at high concentrations ( 500 mcg/ml ) , but at low concentrations ( 12.5 mcg/ml ) , mecysteine lowered the potencies of only three antibiotics and l-cysteine those of only four antibiotics , while acetylcysteine decreased the potencies of six and ethylcysteine those of seven antibiotics . | NA | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
0,
10
]
} | {
"id": "C0001047",
"name": "acetylcysteine",
"pos": [
311,
325
]
} |
inhibition by deoxycytidine , cytidine , and beta-cytosine arabinoside of the induction of alkaline phosphatase activity in hela cells . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
14,
27
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
30,
38
]
} |
thymidine ( dthd ) , deoxycytidine ( dcyd ) , cytidine , and beta-cytosine arabinoside ( ara-c ) inhibited a dose-dependent manner the induction of alkaline phosphatase activity by idurd in hela cells , and 5-iodo-2'-deoxycytidine induced activity in a dose-dependent manner at concentrations similar to those of idurd . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
21,
34
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
222,
230
]
} |
the effect of an antioxidant , disulfiram ( dsf ) , on the carcinogenicities of n-2-fluorenylacetamide ( 2-faa ) and n-hydroxy-n-2-fluorenylacetamide ( n-oh-2-faa ) was examined . | NA | {
"id": "C0000248",
"name": "2-faa",
"pos": [
105,
110
]
} | {
"id": "C0020319",
"name": "n-hydroxy-n-2-fluorenylacetamide",
"pos": [
117,
149
]
} |
the salmonella mutagenesis test system was used to evaluate the in vitro mutagenic potency of n-2-fluorenylacetamide ( 2-faa ) and n-hydroxy-n-2-fluorenylacetamide ( n-oh-2-faa ) mediated by liver and kidney subcellular fractions from x/gf mice , a strain resistant to 2-faa carcinogenesis . | NA | {
"id": "C0000248",
"name": "2-faa",
"pos": [
119,
124
]
} | {
"id": "C0020319",
"name": "n-hydroxy-n-2-fluorenylacetamide",
"pos": [
131,
163
]
} |
[ effect of genetic and environmental factors on the variability of the lipid and lipoprotein concentration in the blood plasma ] . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
72,
77
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
82,
93
]
} |
in patients with edema of the lungs nitroglycerin reduced dyspnoea , in some cases of cardiac asthma it arrested the attack . | NA | {
"id": "C0013404",
"name": "dyspnoea",
"pos": [
58,
66
]
} | {
"id": "C0013405",
"name": "cardiac asthma",
"pos": [
86,
100
]
} |
echocardiography was conducted in 169 patients with ischemic heart disease ( atherosclerotic and postinfarction cardiosclerosis , angina pectoris , unstable angina pectoris , myocardial infarction ) to determine the diagnostic importance of changes in the contractile function of the interventricular septum ( ivs ) . | NA | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
130,
145
]
} | {
"id": "C0002965",
"name": "unstable",
"pos": [
148,
156
]
} |
out of 95 patients with radiolucent gallstones who enrolled in a clinical study with chenodeoxycholic acid ( cdc ) for gallstone dissolution 75 patients with cholecystolithiasis completed 12 months of treatment . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
36,
45
]
} | {
"id": "C0947622",
"name": "cholecystolithiasis",
"pos": [
158,
177
]
} |
this study demonstrates that medical dissolution of gallstones with chenodeoxycholic acid should be performed in patients with radiolucent stones of less than 2 cm in diameter and with a dose above 13 mg cdc/kg body weight/day . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
52,
62
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
139,
145
]
} |
tumors occurred in kidneys having atypical cysts , as dintinguished from kidneys without such cysts , with a frequency greater than would be expected to be due to chance alone ( p = 0.0106 ) . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
0,
6
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
94,
99
]
} |
this form of epithelial hyperplasia , common to both atypical cysts and the multicystic dialysis kidney , may give rise to the renal cell tumors that are reported to occur with increased frequency in acquired cystic disease . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
62,
67
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
138,
144
]
} |
the study of antigen and/or antibody purified from immune complexes in the host and the application of leukocyte adherence inhibition techniques to immunodiagnosis of pancreatic cancer are among the new approaches that may provide effective alternatives in the study of pancreatic tumor antigens . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
28,
36
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
51,
67
]
} |
a number of drugs such as baclofen , diazepam , and pentobarbitone which have been attributed with gaba-like properties behaved like gaba agonists in the head-turn model following either intrapallidal or intraperitoneal injection . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
26,
34
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
133,
137
]
} |
the different sma syndromes can be discriminated by ( a ) age at the first clinical signs of the disease , ( b ) pattern of muscle involvement , ( c ) age at death of other patients within an affected kindred , and ( d ) genetic evidence . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
18,
27
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
97,
104
]
} |
namely , giant cell reparative granuloma , brown tumor of hyperparathyroidism , and true giant cell tumor -- osteoclastoma preferably called giant cell neoplasm . | NA | {
"id": "C0206638",
"name": "osteoclastoma",
"pos": [
109,
122
]
} | {
"id": "C0017525",
"name": "giant cell neoplasm",
"pos": [
141,
160
]
} |
there is considerable evidence that the growing tumor requires a source of unsaturated fatty acids , but the nature of this source and the mechanism of mobilizing the fatty acids from it are obscure . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
75,
98
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
167,
178
]
} |
the effects of 3 dietary fats ( olive oil , canbra oil and butter ) on the fatty acids of blood lipids and on serum lipoproteins were compared in 6 healthy adult outpatients , after a 6-day normocaloric diet including 35 % of the studied fat . | NA | {
"id": "C0012171",
"name": "dietary fats",
"pos": [
17,
29
]
} | {
"id": "C0006494",
"name": "butter",
"pos": [
59,
65
]
} |
addition of synthetic carnitine or coa esters of brominated fatty acids did not interfere with subsequent oxidation of palmitoylcarnitine . | NA | {
"id": "C0007258",
"name": "carnitine",
"pos": [
22,
31
]
} | {
"id": "C0030242",
"name": "palmitoylcarnitine",
"pos": [
119,
137
]
} |
these results are consistent with observations by others that feeding brominated oils leads to brominated fatty acid incorporation into tissue lipids , and indicate why this is so . | NA | {
"id": "C0028908",
"name": "oils",
"pos": [
81,
85
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
143,
149
]
} |
determination of proline in the blood plasma of ceramic industry workers and electric welders and determination of hydroxyproline in welders ' blood plasma were found to be a particularly significant and early index of exposure to ceramic dust or welding fume . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
17,
24
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
115,
129
]
} |
regulation of pool sizes and turnover rates of amino acids in humans : 15n-glycine and 15n-alanine single-dose experiments using gas chromatography-mass spectrometry analysis . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
47,
58
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
75,
82
]
} |
regulation of pool sizes and turnover rates of amino acids in humans : 15n-glycine and 15n-alanine single-dose experiments using gas chromatography-mass spectrometry analysis . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
47,
58
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
91,
98
]
} |
the plasma 15n-glycine and 15n-alanine isotope-enrichment time-decay curves over the first hour following a single i.v . dose of 15-amino acid represent mostly the hepatic uptake of glycine and alanine from the extracellular pool . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
15,
22
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
132,
137
]
} |
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