text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
small bowel lesions secondary to direct laceration are recognized to be more probable than due to indirect trauma . | NA | {
"id": "C0043246",
"name": "laceration",
"pos": [
40,
50
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} |
the apparent optimum temperature of free enzyme was 50 degrees c and of the immobilized enzyme 60 degrees c . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
41,
47
]
} | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
76,
94
]
} |
the heat of the reaction ( delta e ) , accompanied by the process , was calculated from the slope of the arrhenius equation to be 56 770 cal/mole for free enzyme and 36 640 cal/mole for immobilized enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
155,
161
]
} | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
186,
204
]
} |
the standard free energy change ( delta g ) and the standard entropy change ( delta s ) were found to be + 241 cal/mole and + 186.6 cal/mole/degree at 30 degrees c for free enzyme and + 142 cal/mole and 120.5 cal/mole/degree at 30 degrees c for immobilized enzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
173,
179
]
} | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
245,
263
]
} |
a diagnosis of defective immune state was established on the basis of the low igg-serum level ( though pemphigus antibodies were present ) , reduced t cell count in blood , weak pha stimulation of lymphocytes , lack of skin reactivity to recall antigens and to most other bacterial antigens tested . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
245,
253
]
} | {
"id": "C0003321",
"name": "bacterial antigens",
"pos": [
272,
290
]
} |
rabbit antiserum to 11 alpha-hydroxyprogesterone-hemisuccinate-bovine serum albumin was previously obtained and anti-rabbit gamma globulin goat serum was used as second antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
7,
16
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
169,
177
]
} |
the influence of glycine , the simplest amino acid , on pituitary function has been investigated in the present study . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
17,
24
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
40,
50
]
} |
intussusception in the first month of life is a distinct clinical and pathological entity , presenting as bowel obstruction in the first days and usually led by a tumor . | NA | {
"id": "C0021933",
"name": "intussusception",
"pos": [
0,
15
]
} | {
"id": "C0021843",
"name": "bowel obstruction",
"pos": [
106,
123
]
} |
pga 's were the only prostaglandins tested besides pge 's which stimulated adenylate cyclase at less than 10-4m . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
21,
35
]
} | {
"id": "C0033559",
"name": "pge 's",
"pos": [
51,
57
]
} |
a study of prostaglandin f2alpha as the luteolysin in swine : ii characterization and comparison of prostaglandin f , estrogens and progestin concentrations in utero-ovarian vein plasma of nonpregnant and pregnant gilts . | NA | {
"id": "C0012471",
"name": "prostaglandin f2alpha",
"pos": [
11,
32
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
100,
115
]
} |
a method for quantitative determination of methylprednisolone and hydrocortisone in plasma using added methylprednisolone acetate as internal standard and high pressure liquid chromatography is presented . | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
43,
61
]
} | {
"id": "C0600901",
"name": "methylprednisolone acetate",
"pos": [
103,
129
]
} |
in the he stained histological slides the morphological changes and the percentages of the cells in the granulation tissue and in the stripping film autoradiograms the percentages of radioactively labeled fibroblasts and hepatocytes were determined . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
205,
216
]
} |
cholestyramine known to reduce oxalate excretion in hyperuxaluria associated with ileal resection did not directly affect absorption of oxalic acid , but decreased the enhanced absorption of oxalic acid induced by bile acids . | NA | {
"id": "C0029988",
"name": "oxalate",
"pos": [
31,
38
]
} | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
191,
202
]
} |
determination of indole and 3-methylindole in plasma and rumen fluid from cattle with fog fever or after l-tryptophan administration . | NA | {
"id": "C0021242",
"name": "indole",
"pos": [
17,
23
]
} | {
"id": "C0037248",
"name": "3-methylindole",
"pos": [
28,
42
]
} |
although the mean levels for igg , iga and igm for the group as a whole were within the normal range , 8 individual cases showed low levels of one or more immunoglobulin class , suggesting a disturbance in immunoglobulin production . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
155,
175
]
} | {
"id": "C0020835",
"name": "a",
"pos": [
198,
199
]
} |
the gastrointestinal blood loss during intake of two ampicillin esters ( pivampicillin and bacampicillin ) was studied in 10 male volunteers . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
53,
63
]
} | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
73,
86
]
} |
the poc2 values increased markedly both in the burn areas and in the distant tissues immediately after the trauma and reached their maximum within 1-3 hours post burn . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} | {
"id": "C0006434",
"name": "burn",
"pos": [
162,
166
]
} |
clinical detection of alcohol involvement ( ai ) and its recording ( ethyl sign ) in accident patients was evaluated by comparing the ethyl signs with blood alcohol concentrations ( bac ) in 1012 injury victims . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
22,
29
]
} | {
"id": "C0684262",
"name": "blood alcohol",
"pos": [
151,
164
]
} |
of the 337 bac-positive cases 50 % had a positive ethyl sign , while an additional 13 % had some reference to alcohol in their patient notes . | NA | {
"id": "C0684262",
"name": "bac",
"pos": [
11,
14
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
110,
117
]
} |
the results of an evaluation over 4 years ( 1973-1976 ) of 16,620 bm-tests ( boehringer-mannheim newborn screening for cystic fibrosis ) at 8 hospitals in switzerland are presented and the data from analysis of albumin , protein and alpha1-antitrypsin concentrations , and on trypsin-inhibitory capacity of the meconia are discussed . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
211,
218
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
221,
228
]
} |
glibenclamide , a hypoglycemic sulfonylurea , is extensively metabolized by the body and eliminated primarily in the form of its hydroxylated derivatives . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
0,
13
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
31,
43
]
} |
the release of [ 3h ] dopamine also decreased in the left caudate nucleus and increased in the right structure when dopamine was applied to the left substantia nigra which reduces the activity of the left dopaminergic pathway . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
22,
30
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
205,
217
]
} |
erythropoietin or colony-stimulating factor , or both , were added to rat or mouse marrow cell cultures , and the responses to each inducer were measured . | NA | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
0,
14
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
18,
43
]
} |
colony-stimulating factor caused the suppression of erythropoietin-stimulated hemoglobin synthesis , and erythropoietin caused the suppression of the granulocyte-macrophage colony formation that is dependent on colony-stimulating factor . | NA | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
52,
66
]
} | {
"id": "C0009392",
"name": "colony-stimulating",
"pos": [
211,
229
]
} |
marrow cells from plethoric rats were more sensitive to suppression of erythropoietin action by colony-stimulating factor than were normal marrow cells . | NA | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
71,
85
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
96,
121
]
} |
the authors report 6 cases of acute respiratory failure complicating chronic bronchial and lung disease admitted to hospital with the diagnosis of : heart disease , 3 cases , pulmonary oedema , pulmonary embolism , atrial flutter ; | NA | {
"id": "C0024115",
"name": "lung disease",
"pos": [
91,
103
]
} | {
"id": "C0034063",
"name": "pulmonary oedema",
"pos": [
175,
191
]
} |
distribution of antibodies to the troponin complex , troponin-c and troponin-i in chicken skeletal muscle as determined by a simplified method for immuno-electron microscopy . | NA | {
"id": "C0041199",
"name": "troponin complex",
"pos": [
34,
50
]
} | {
"id": "C0077401",
"name": "troponin-i",
"pos": [
68,
78
]
} |
antisera against the troponin complex , troponin-c and troponin-i have been utilized to locate these proteins in normal , adult chicken skeletal muscle and in filaments prepared from chicken acetone dried powder . | NA | {
"id": "C0041199",
"name": "troponin complex",
"pos": [
21,
37
]
} | {
"id": "C0077401",
"name": "troponin-i",
"pos": [
55,
65
]
} |
glycerinated chicken breast muscle was treated with the antisera , unreacted antibody was washed from the muscle , and a goat anti-rabbit gamma-globulin was added to enhance the electron density of the antigen-antibody complexes . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
56,
64
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
210,
218
]
} |
glycerinated chicken breast muscle was treated with the antisera , unreacted antibody was washed from the muscle , and a goat anti-rabbit gamma-globulin was added to enhance the electron density of the antigen-antibody complexes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
77,
85
]
} | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
202,
228
]
} |
steroids which reacted significantly with the antiserum were found to be 5alpha-androstane-3,17-dione , 5beta-androstane-3,17-dione , and 6beta-hydroxy-4-androstene-3,17-dione . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
0,
8
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
110,
120
]
} |
after column chromatography on alumina , however , the only significantly cross-reacting steroids were the 5alpha and 5beta-androstane-3,17-diones , while cross-reactivity from other steroids was reduced to less than 1 % . | NA | {
"id": "C0002854",
"name": "androstane",
"pos": [
124,
134
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
183,
191
]
} |
liver dysfunction and exposure to the hepatitis b antigen were assessed by serum transaminase ( sgpt and sgot ) levels and hbsag and anti-hbs during a three year period in a group of 118 patients with factor viii or factor ix deficiency . | NA | {
"id": "C0019165",
"name": "hepatitis b antigen",
"pos": [
38,
57
]
} | {
"id": "C0019168",
"name": "hbsag",
"pos": [
123,
128
]
} |
the alkaline phosphatase enzyme , isolated by morton 's method from leukocytes of sheep , goats , and pigs gave after agarose elctrophoresis two isoenzyme fractions moving to the positive pole at the sites of the alpha 1- and alpha 2-globulins of the blood serum . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
25,
31
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
145,
154
]
} |
three sorbents were employed to establish the most appropriate conditions for the application of a fast , readily applicably and highly sensitive method -- silica gel g , dg and kiselgur `` '' merk '' '' , as well as 14 mobile phases -- monocompound ( n-hexane , n-heptane , acetone benzol and toluol ) , double combinations ( hexane-acetone 4:1 , hexane-acetone 9:1 , hexane-benzol 1:1 , hexane-benzol 4:1 , heptane-acetone 7:1 , benzol-hexane 4:1 , benzol-acetone 9:1 , and petrolium ether-tetrachlormethane ) and triple combinations ( acetone-toluol-hexane 1:15 and 5 developers ( a diazosalt , bromine vapours + diazosalt , palladium bichloride , bromphenol blue , and silver nitrate , sodium hydroxide , ammonia gas ) . | NA | {
"id": "C0002607",
"name": ", ammon",
"pos": [
707,
714
]
} | {
"id": "C0017110",
"name": "a g",
"pos": [
715,
718
]
} |
a total of 28,159 blood serum samples have been examined for brucellosis , 87 -- for leptospirosis , 84 -- for toxoplasmosis , 554 -- for the presence of rickettsii and neoreckettsii , and 193 -- for total protein content , albumin , and protein fractions , taken from cows in the course of the years on 40 dairy farms in the district of rousse . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
224,
231
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
238,
245
]
} |
there were no precipitins in the plasma of the donors , and the titer of the agglutinins and the cytophile antibodies was very low . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
14,
25
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} |
nuclear non-histone protein content of g0/g1 cells as related to growth fraction in mouse mammary tumors . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
0,
7
]
} | {
"id": "C0019652",
"name": "histone",
"pos": [
12,
19
]
} |
in eight mouse mammary tumors with varying growth fractions dna and non-histone nuclear protein ( nhnp ) were determined by absorption cytophotometry of feulgen-naphthol yellow s stained , isolated cells . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
72,
79
]
} | {
"id": "C0028589",
"name": "nuclear protein",
"pos": [
80,
95
]
} |
the mean nhnp content of cells with postmitotic dna content ( g0 + g1 ) increased with increasing growth fraction . | NA | {
"id": "C0019652",
"name": "nhnp",
"pos": [
9,
13
]
} | {
"id": "C0028589",
"name": "nhnp",
"pos": [
9,
13
]
} |
the results are interpreted as follows : a ) g0 cells differ from g1 cells by their lower content of nhnp . | NA | {
"id": "C0019652",
"name": "nhnp",
"pos": [
101,
105
]
} | {
"id": "C0028589",
"name": "nhnp",
"pos": [
101,
105
]
} |
if it is assumed that the g0 and g1 compartments are arranged in series , the cells in the transition from g0 to late g1 may account for the unimodality and skewedness of the nhnp frequency distributions of postmitotic cells . | NA | {
"id": "C0019652",
"name": "nhnp",
"pos": [
175,
179
]
} | {
"id": "C0028589",
"name": "nhnp",
"pos": [
175,
179
]
} |
[ excretion of adrenaline , noradrenaline and luteinizing hormone during treatment with arsenate mineral water of chronic adnexitis ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
28,
41
]
} |
[ estradiol and pregnanldiol excretion in threatening miscarriages in late period of pregnancy depending on the cause of miscarriage ] . | NA | {
"id": "C0000821",
"name": "threatening miscarriages",
"pos": [
42,
66
]
} | {
"id": "C0000786",
"name": "miscarriage",
"pos": [
121,
132
]
} |
in 51 of them mixed tumors were noted , adenomas , angiomas , lipomas - in 8 , cancer , sarcoma , metastases - in 16 , chronic parotitis simulating the tumor - in 7 . | NA | {
"id": "C0026277",
"name": "mixed tumors",
"pos": [
14,
26
]
} | {
"id": "C0001430",
"name": "adenomas",
"pos": [
40,
48
]
} |
as to the amino acids content the protein fractions differ from one another , with lysine level in albumin amounting to 4.07 , globulin -- 2.46 , prolamine -- 0.88 and gluteline -- 3.15 per cent . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
34,
41
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
127,
135
]
} |
the antigenic activity of the tissue culture smallpox vaccine was superior to that of dermal vaccine used in the same dose : the geometric mean neutralizing antibody titre after vaccination with the tissue and dermal preparations was 1 : 256 and 1 : 158 , respectively , and the antibody rise was 4.5- and 2.5-fold . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
144,
165
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
279,
287
]
} |
isodensity centrifugation of in vitro 125i-labeled preparation of nucleic acid from influenza virus in cesium sulphate gradient also reveals dna molecules , in addition to rna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
66,
78
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
141,
154
]
} |
therapy with anticonvulsant drugs reduces the frequency and severity of seizures in many but not all epileptic patients . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
72,
80
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
101,
110
]
} |
samples of blood and joint fluid from thirty patients who had taken acetyl-salicylic acid were examined for occurrence of salicylates . | NA | {
"id": "C0004057",
"name": "acetyl-salicylic acid",
"pos": [
68,
89
]
} | {
"id": "C0036077",
"name": "salicylates",
"pos": [
122,
133
]
} |
in 76 women ( 37.2 % ) the double neoplasms were situated in the genital region ( local multiplicity ) , whilst in 128 cases the second neoplasm was situated in a distant organ , with cancer of the breast predominating ( 61 cases = 29.9 % ) . | NA | {
"id": "C0027651",
"name": "neoplasms",
"pos": [
34,
43
]
} | {
"id": "C0085183",
"name": "second neoplasm",
"pos": [
129,
144
]
} |
[ fluorimetric determination of urinary norepinephrine and epinephrine : assessment of the aluminium oxide-trihydroxyindole method and improvement by the analysis of fluorescence spectra ( author 's transl ) ] . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
40,
54
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
59,
70
]
} |
non-pregnant and day-14 pregnant mice treated with a single dose of primidone ( 5 to 150 mg/kg ) by gastric intubation were bled at 1 and 4 h after dosage , and the plasma analysed for primidone , phenobarbitone and phenylethylmalondiamide ( pema ) by g.l.c . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
68,
77
]
} | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
197,
211
]
} |
plasma levels of primidone and pema , but not phenobarbitone , were much lower in the day-14 pregnant mouse than in the non-pregnant animal . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
17,
26
]
} | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
46,
60
]
} |
the concentration of pema exceeded that of primidone between 3-8 h and then began to decrease in the multiple-dose groups , a similar pattern was established for phenobarbitone also , although the concentrations were lower than those of pema . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
43,
52
]
} | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
162,
176
]
} |
in dependence upon the body-weight the metabolism of the diabetics with overweight and underweight also differs concerning the insulin secretion and by the size of the glycogen accumulation and the behaviour in the degradation of the glycogen of the liver ( decreased degradation in diabetics with overweight ) . | NA | {
"id": "C0005910",
"name": "body-weight",
"pos": [
23,
34
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
298,
308
]
} |
the coexistences , overlappings and transitional forms among the special autoimmune diseases render the diagnostics more difficult and explain the great variety of pictures of the sle . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
73,
92
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
180,
183
]
} |
[ insulin resistance and blood glucose replacement rates in liver cirrhosis . studies with 14c-glucose ( author 's transl ) ] . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
25,
38
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
95,
102
]
} |
the complexation behaviour of cu ( ii ) with di- and tripeptides containing the aromatic amino acids phenylalanine or typtophan has been investigated at different ph-values and compared with results obtained with di- and triglycine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
80,
100
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
101,
114
]
} |
heating of milk , depending on the conditions , caused a decrease of the aflatoxin-content of between 12 and 35 % when making butter from naturally contaminated cream 23 % ( 18-28 % ) of the aflatoxin m1 appeared in the butter , whereas the buttermilk contained the major amount of aflatoxin . | NA | {
"id": "C0085181",
"name": "aflatoxin m1",
"pos": [
191,
203
]
} | {
"id": "C0001734",
"name": "aflatoxin",
"pos": [
282,
291
]
} |
in order to concentrate and separate the trace cobalt quantities from the main matrix constituents a micro-solvent-extraction system with ammonium pyrrolidinedithiocarbamate ( apdc ) as heavy metal chelating reagent and toluene as extraction solvent was developed . | NA | {
"id": "C0009148",
"name": "cobalt",
"pos": [
47,
53
]
} | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
186,
197
]
} |
the major flavonol glycosides of ripe blackcurrants ( ribes nigrum cv . silvergieters schwarze ) , myricetin 3-beta-d-glucopyranoside , rutin , and isoquercitrin , have been isolated in crystalline form . | NA | {
"id": "C0060444",
"name": "flavonol",
"pos": [
10,
18
]
} | {
"id": "C0035976",
"name": "rutin",
"pos": [
136,
141
]
} |
with the help of morphological findings the pathogenetic effect of the toxins ( exotoxin and enterotoxin ) of bacillus cereus is discussed . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
71,
77
]
} | {
"id": "C0015309",
"name": "exotoxin",
"pos": [
80,
88
]
} |
with the help of morphological findings the pathogenetic effect of the toxins ( exotoxin and enterotoxin ) of bacillus cereus is discussed . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
71,
77
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
93,
104
]
} |
the dimension of accumulation depends on various factors : the chemical nature of the ion involved , its concentration in the solution and the solutions ph-value , the nature of the anions present as well as the nature and concentration of other kations . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
10,
13
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
182,
188
]
} |
glucoamylase ( alpha-1,4-glucan glucohydrolase , ec 3.2.1.3 ) has been covalently linked to dialdehyde cellulose resulting in an immobilized enzyme containing 0.98 % protein and an activity of 4.5 mg of the native enzyme per g of matrix , i.e . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
129,
147
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
214,
220
]
} |
the keratinocytes of the separated epidermis revealed intracytoplasmic vacuoles , widening of the intercellular spaces and , in some cells , vacuolization of the mitochondria . | NA | {
"id": "C0022567",
"name": "separated",
"pos": [
25,
34
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} |
the effect of bleeding on spleen colony-forming units ( cfu-s ) and on in vitro colony-forming cells with colony-stimulating factor ( cfu-c ) and erythropoietin ( cfu-e ) has been evaluated . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
106,
131
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
146,
160
]
} |
when mc 's were abolished by feeding or pg infusion , simultaneous 13-nle-motilin administration was without effect on spike activity , but slightly attenuated the accelerating effect of gastrin on the gastric pacemaker frequency . | NA | {
"id": "C0030859",
"name": "pg",
"pos": [
40,
42
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
187,
194
]
} |
the importance of recent histological classifications in non hodgkin lymphomas is emphasized particularly with respect to the differentiation between lymphomas of `` '' low grade '' '' and `` '' high grade '' '' malignancy . | NA | {
"id": "C0024305",
"name": "non hodgkin lymphomas",
"pos": [
57,
78
]
} | {
"id": "C0079747",
"name": "lymphomas",
"pos": [
150,
159
]
} |
therapeutically , supraventricular tachycardias may be terminated by ( 1 ) overdrive suppression , ( 2 ) delivery of a single stimulus or two serial stimuli or repetitive stimulation at a rate slower than the tachycardia ( competitive stimulation ) and ( 3 ) orthorhythmic stimulation . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardias",
"pos": [
18,
47
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
209,
220
]
} |
peripheral plasma from four postmenopausal women was analysed for oestrone ( e1 ) and oestradiol ( e2 ) during 48 hours after oral intake of a single tablet of 2 mg progynon ( oestradiol valerianate ) . | NA | {
"id": "C0688788",
"name": "oral",
"pos": [
126,
130
]
} | {
"id": "C0014912",
"name": "oestradiol",
"pos": [
176,
186
]
} |
in one series of 68 cases of midtrimester pregnancies ( 12-24 weeks ) , legal abortion was induced by one intraamniotic injection of 2.5 mg 15-methyl prostaglandin f 2alpha . | NA | {
"id": "C0032980",
"name": "midtrimester",
"pos": [
29,
41
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
42,
53
]
} |
tonsillar lymphocytes produced classical interferon ( type i ) in response to ndv infection and produced immune interferon ( type ii ) in response to pha , ppd or histo-incompatible antigens . | NA | {
"id": "C0021747",
"name": "interferon",
"pos": [
41,
51
]
} | {
"id": "C0021745",
"name": "immune interferon",
"pos": [
105,
122
]
} |
from the literature review of ultrastructure of glomus tumor , hemangiopericytomas ( hpc ) , leiomyoblastomas and leiomyomas , the glomus tumor appeared to exist as an intermediate form between hpc and leiomyomas which were considered to be in a broad spectrum of smooth muscle tumors . | NA | {
"id": "C0086533",
"name": "leiomyoblastomas",
"pos": [
93,
109
]
} | {
"id": "C0023267",
"name": "leiomyomas",
"pos": [
202,
212
]
} |
a review of the literatures on the malignant hamartoma of the lung revealed rare incidences of the tumor , but hamartoma and hamartomatous lesions of the lung should be regarded as one of the histopathological backgrounds where pulmonary carcinoma may arise . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
99,
104
]
} | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
125,
138
]
} |
among the anorectic phenethylamines the 5ht-releasing effect decreased in the following order , aminorex , amphetamine , clophorex , chlorphentermine , diethylpropion ( amphepramon ) , phentermine . | NA | {
"id": "C0008283",
"name": "chlorphentermine",
"pos": [
133,
149
]
} | {
"id": "C0031447",
"name": "phentermine",
"pos": [
185,
196
]
} |
adrenaline and noradrenaline induce ionic outflows which like those evoked by nerve stimulation are inhibited by the beta-adrenoreceptor blocker propranolol , alpha-adrenoreceptor blockers being without effect . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
the seasonal variations in circulating 25-hydroxycholecalciferol ( 25-hcc ) were studied in 102 alcoholics with fatty liver disease without histologic signs of cirrhosis and in 35 patients with alcoholic cirrhosis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
118,
131
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
204,
213
]
} |
the prognostically unfavourable factors regarding complete relief from seizures were : i ) preoperative presence of grand mal , ii ) age at onset of epilepsy or of the first grand mal seizure between 5 and 19 years of age , iii ) preoperative duration of epilepsy of over ten years and of grand mal of over one year . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
71,
79
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
255,
263
]
} |
treatment of casein , bovine serum albumin , lysozyme , wool or polylysine with acetamido- and phenylacetamido acrylic acid methyl esters at ph 9-10 converted varying amounts of lysine to lysinoalanine residues . | NA | {
"id": "C0032518",
"name": "polylysine",
"pos": [
64,
74
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
178,
184
]
} |
the contribution of individual milk proteins , namely the beta-lactoglobulins , alpha-lactalbumin and chi-casein , to the formation of crosslinks is studied with respect to heating temperature and time , ph and atmosphere . | NA | {
"id": "C0026138",
"name": "milk proteins",
"pos": [
31,
44
]
} | {
"id": "C0007332",
"name": "casein",
"pos": [
106,
112
]
} |
alkali-treated proteins and lysinoalanine , an unusual amino acid formed in proteins during alkali treatment , have been shown to produce a renal alteration characterized by nuclear and cytoplasmic enlargement , with alterations in dna synthesis , mitotsis and nucleoprotein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
15,
23
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
261,
274
]
} |
the behavior of the primary products ( 1-amino-1-deoxy-2-ketose-derivatives ) from amino acids and monosaccharides in the maillard reaction to the action of pepsin , trypsin , chymostrypsin and of heating has been investigated , in order to test the possibility of their utilization as foodstuff integrators . | NA | {
"id": "C0022637",
"name": "ketose",
"pos": [
57,
63
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
99,
114
]
} |
as precipitation of contaminating non-viral protein increases with increasing peg concentrations , best results with respect to purity and recovery were obtained at 5 % peg 6000 . | NA | {
"id": "C0032483",
"name": "peg",
"pos": [
78,
81
]
} | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
169,
177
]
} |
ten patients with proven pulmonary aspergillosis and five selected control subjects without aspergillosis but with other pulmonary disorders were scanned after the injection of 2-3 mci 87msr citrate . | NA | {
"id": "C2350529",
"name": "pulmonary aspergillosis",
"pos": [
25,
48
]
} | {
"id": "C0004030",
"name": "aspergillosis",
"pos": [
92,
105
]
} |
and intimal fibrous proliferation results from some stimulus , probably fibrin deposition on injured intima , which causes stimulation of smooth muscle cells to become fibroblasts or `` '' myointimal cells '' '' . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
168,
179
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
152,
156
]
} |
the disparity between the severity of coronary disease and the occurrence of the various types of ihd suggest that atherosclerosis itself does not precipitate attacks of chest pain . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0151744",
"name": "ihd",
"pos": [
98,
101
]
} |
effect of procainamide , propranolol and verapamil on mechanism of tachycardia in patients with chronic recurrent ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
67,
78
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
114,
137
]
} |
procainamide ( 1 ) lengthened the effective refractory period of the right ventricle , ( 2 ) affected the tachycardia zone , ( 3 ) reduced ventricular rate during tachycardia , and ( 4 ) lengthened the interval between the tachycardia-initiating premature ventricular beat and the first qrs complex of tachycardia . | NA | {
"id": "C0042514",
"name": "ventricular",
"pos": [
139,
150
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
302,
313
]
} |
this experience indicates that in the presence of strong evidence of mitral stenosis , an unexpectedly normal mitral valve echogram should initiate a thorough echographic search for cor triatriatum , a treatable cardiac malformation whose diagnosis can easily be missed on `` '' routine '' '' echocardiographic studies . | NA | {
"id": "C0009995",
"name": "cor triatriatum",
"pos": [
182,
197
]
} | {
"id": "C0018798",
"name": "cardiac",
"pos": [
212,
219
]
} |
during determinations of the forms of vitamin b12 in foods and human tissues several samples yielded a growth zone on bioautography which was distinct from those due to methylcobalamin , adenosylcobalamin , hydroxocobalamin , or cyanocobalamin . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
207,
223
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
229,
243
]
} |
the hydroxocobalamin is then converted to ammonia cobalamin , which is more resistant to attack by ( bi ) sulfite ions . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
4,
20
]
} | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
50,
59
]
} |
the rapid conversion of hydroxo ( aquo ) cobalamin to sulfitocobalamin in the dark raises the possibility that hydroxocobalamin in foods may be converted to the less well absorbed sulfitocobalamin in the upper gastrointestinal tract . | NA | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
41,
50
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
111,
127
]
} |
the respective roles of reduced dietary intake and malabsorption in the pathogenesis of weight loss in persons with chronic tropical sprue have been evaluated . dietary intake was found to be significantly ( p less than 0.001 ) less in a group of 45 patients with tropical sprue , all of whom had anorexia due to deficiency of folate and/or vitamin b12 , than in a group of 51 healthy puerto ricans . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
51,
64
]
} | {
"id": "C0038054",
"name": "tropical sprue",
"pos": [
264,
278
]
} |
serum albumin , total globulin and gamma-globulin concentrations were determined in all and immunoglobulins ig-g , ig-a , ig-m and ig-d in 36 of them . | NA | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
35,
49
]
} | {
"id": "C0021027",
"name": "ig",
"pos": [
131,
133
]
} |
animals in group iii were sensitized by amebic antigen and in group iv by bacterial antigen before inoculations . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
47,
54
]
} | {
"id": "C0003321",
"name": "bacterial antigen",
"pos": [
74,
91
]
} |
a nationwide survey of heavy metal absorption in children living near primary copper , lead , and zinc smelters . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
23,
34
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
78,
84
]
} |
a nationwide survey of heavy metal absorption in children living near primary copper , lead , and zinc smelters . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
23,
34
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
87,
91
]
} |
a nationwide survey of heavy metal absorption in children living near primary copper , lead , and zinc smelters . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
23,
34
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
98,
102
]
} |
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