text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
however , these patients were thought to be at risk for adrenal insufficiency : neither had moniliasis or adrenocortical insufficiency at present , but the features of the hypoparathyroidism adrenal insufficiency-moniliasis syndrome appeared at different ages and in differing sequences . | NA | {
"id": "C0020595",
"name": "adrenocortical insufficiency",
"pos": [
106,
134
]
} | {
"id": "C0001623",
"name": "adrenal insufficiency",
"pos": [
191,
212
]
} |
eight patients with low levels , or absence , of all the major serum immunoglobulins had conjunctivitis or keratoconjunctivitis associated with bacterial infection . | NA | {
"id": "C0009763",
"name": "conjunctivitis",
"pos": [
89,
103
]
} | {
"id": "C0022573",
"name": "keratoconjunctivitis",
"pos": [
107,
127
]
} |
also , the rate at which sulfated glycosaminoglycans were removed from cultured corneal fibroblasts in mcd by secretion and degradation more closely resembled that of normal cells than those with the systemic mucopolysaccharidoses . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
88,
99
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
167,
179
]
} |
the secretion of sulfated glycosaminoglycans into the nutrient medium by corneal fibroblasts from patients with mcd occurred at a linear rate comparable to that of other cells studied . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
81,
92
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
170,
175
]
} |
the intake of about 10 mg fluoride per day , given as naf , resulted in a two- to threefold increase of the urinary and fecal fluoride excretion . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
54,
57
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
126,
134
]
} |
cortical and medullary tissue from potassium-depleted and control animals accumulated extracellular choline and sequentially converted it to phosphorylcholine , cytidine diphosphocholine ( cdp-choline ) , and choline phosphoglyceride , thereby demonstrating that renal cells can utilize the kennedy pathway for phospholipid synthesis . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
100,
107
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
141,
158
]
} |
cortical and medullary tissue from potassium-depleted and control animals accumulated extracellular choline and sequentially converted it to phosphorylcholine , cytidine diphosphocholine ( cdp-choline ) , and choline phosphoglyceride , thereby demonstrating that renal cells can utilize the kennedy pathway for phospholipid synthesis . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
100,
107
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
189,
200
]
} |
the apparent km and vmax of the kinase reaction which converts entering [ 14c ] choline to [ 14c ] phosphorylcholine were unchanged during potassium depletion . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
80,
87
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
99,
116
]
} |
these results indicate that increased renal choline phosphoglyceride formation during potassium depletion can occur via the kennedy pathway and appears to be mediated by increases in choline uptake and the rate of cdp-choline incorporation into phospholipid , the first and last steps of the pathway . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
44,
51
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
214,
225
]
} |
thirty minutes of anoxic perfusion resulted in increased tissue concentrations of five essential amino acids ( methionine , histidine , leucine , lysine , and valine ) and a decreased tissue level of the essential amino acids threonine and phenylalanine . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
111,
121
]
} | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
204,
225
]
} |
thirty minutes of anoxic perfusion resulted in increased tissue concentrations of five essential amino acids ( methionine , histidine , leucine , lysine , and valine ) and a decreased tissue level of the essential amino acids threonine and phenylalanine . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
87,
108
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
226,
235
]
} |
ulnar nerve entrapment is thought to represent one syndrome in a spectrum of diseases involving the medial side of the elbow in baseball players . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
51,
59
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
77,
85
]
} |
melanocytes and clump cells ( macrophages ) , and mast cells could be distinguished , as well as fibroblasts , round cells , and non striated muscle cells , melanocytes lost their pigment granules temporarily , but not their ability to produce new ones again after a certain adaptation period . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
97,
108
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
149,
154
]
} |
determination of radioactivity of proline and hydroxyproline in tissue hydrolysates after the elimination of interference by primary amino acids by deamination . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
34,
41
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
46,
60
]
} |
the authors conclude that whole-lung lavage is a safe and effective palliative procedure in pulmonary alveolar proteinosis and in the treatment of patients with pulmonary disease , such as cystic fibrosis or asthma , in which filling of the lung acini by liquid or solid material impairs oxygenation of the pulmonary capillary blood . | NA | {
"id": "C0034050",
"name": "pulmonary alveolar proteinosis",
"pos": [
92,
122
]
} | {
"id": "C0024115",
"name": "pulmonary disease",
"pos": [
161,
178
]
} |
there are difficulties in measuring red cell glycerides mainly because the amount found in erythrocytes is so differne from that of other lipids in blood cells . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
45,
55
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
138,
144
]
} |
the methods currently used for estimating glycerides in serum can be used here only after removing these other lipids . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
42,
52
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
111,
117
]
} |
the distribution of glycerides in erythrocytes is ver different from that of serum : serum contains mainly triglycerides while there are diglycerides as well as triglycerides in erythrocytes ( on average 3,4 micro mol/1 of triglycerides and 1,7 mumol/1 of diglycerides ) . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
20,
30
]
} | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
223,
236
]
} |
the distribution of glycerides in erythrocytes is ver different from that of serum : serum contains mainly triglycerides while there are diglycerides as well as triglycerides in erythrocytes ( on average 3,4 micro mol/1 of triglycerides and 1,7 mumol/1 of diglycerides ) . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
20,
30
]
} | {
"id": "C0012262",
"name": "diglycerides",
"pos": [
256,
268
]
} |
authors describe three cases of di giorge 's syndrome ( thymic and parathyroid aplasia ) proved through anatomical study postmorten , associated with cardiac malformations ( tetralogy of fallot with pulmonary atresia , persistent truncus arteriosus and large patent ductus arteriosus ) . | NA | {
"id": "C0018798",
"name": "cardiac",
"pos": [
150,
157
]
} | {
"id": "C0039685",
"name": "tetralogy of fallot",
"pos": [
174,
193
]
} |
authors describe three cases of di giorge 's syndrome ( thymic and parathyroid aplasia ) proved through anatomical study postmorten , associated with cardiac malformations ( tetralogy of fallot with pulmonary atresia , persistent truncus arteriosus and large patent ductus arteriosus ) . | NA | {
"id": "C0018798",
"name": "cardiac",
"pos": [
150,
157
]
} | {
"id": "C0013274",
"name": "patent ductus arteriosus",
"pos": [
259,
283
]
} |
although exhalation of mercury vapor was a major route of excretion and urinary mercury rose fivefold with administration of penicillamine , excretion by all routes , estimated for the year after injection , represented only 1 % of the dose . | NA | {
"id": "C1373186",
"name": "route of excretion",
"pos": [
49,
67
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
141,
150
]
} |
these cultures accurately determine the number and proliferative activity of the precursor cells of each population and can also be used to monitor the levels of specific regulatory factors ( for example , erythropoietin , colony-stimulating factor ) in the serum or urine of such patients . | NA | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
206,
220
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
223,
248
]
} |
[ comparative physiological effects of partially hydrogenated herring oils and rapeseed oil in the rat . ii . very short-term and medium term effects on the lipids of heart , lever and adipose tissue ] . | NA | {
"id": "C0028908",
"name": "oils",
"pos": [
70,
74
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
157,
163
]
} |
hyaline membrane disease or respiratory distress syndrome of prematurely born infants is more common in males , in caucasians , has a familial predisposition , and is associated with maternal diabetes and delivery by cesarean section before the onset of labor . | NA | {
"id": "C0020192",
"name": "hyaline membrane disease",
"pos": [
0,
24
]
} | {
"id": "C0035220",
"name": "respiratory distress syndrome",
"pos": [
28,
57
]
} |
at the present time , neither the etiologic factors nor the pathophysiologic mechanisms that lead to the development of endolymphatic hydrops or meniere 's disease are known ; | NA | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
120,
141
]
} | {
"id": "C0025281",
"name": "meniere 's",
"pos": [
145,
155
]
} |
the effect of various concentrations of ammonium sulfate , sodium and potassium chlorides and sulfates on biosynthesis of polymyxin m by bac . polymyxa ross . on media containing wheet meal as the carbon source was studied . | NA | {
"id": "C0002620",
"name": "ammonium sulfate",
"pos": [
40,
56
]
} | {
"id": "C0038720",
"name": "sulfates",
"pos": [
94,
102
]
} |
sensitivity of 1492 strains of the causative agents of the surgical purulent infections , i. e. pathogenic staphylococcus , proteus , ps . aeruginosa and e. coli to benzylpenicillin , streptomycin , levomycetin , tetracycline , erythromycin , oleandomycin , monomycin , kanamycin , novobiocin , ampicillin , oxacillin , ceporin , gentamicin and rifampicin was studied . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
165,
181
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
295,
305
]
} |
the antileukemic activity of karminomycin and rubomycin was studied comparatively in parallel experiments with respect to 4 strains of transplantable leukemia , i.e . acute non-differentiated leukemia la , acute lymphoblast leukemia , l-1210 and p-388 and subacute lymphoblast leukemia no . | NA | {
"id": "C0007308",
"name": "karminomycin",
"pos": [
29,
41
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
46,
55
]
} |
the more pronounced antileukemic activity of karminomycin was especially evident from histological examinations , which showed lower infiltration of the organs and tissues of the mice treated with karminomycin by the leukemic cells as compared to the animals treated with rubomycin . | NA | {
"id": "C0007308",
"name": "karminomycin",
"pos": [
45,
57
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
272,
281
]
} |
the in vitro activity of sisomicin , netilmicin , nafcillin , and oxacillin against 35 strains of staphylococcus aureus isolated from blood cultures of patients with endocarditis or septicemia was studied . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
25,
34
]
} | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
37,
47
]
} |
two hundred and three recent clinical isolates of enterococci were tested for susceptibility to streptomycin , kanamycin , amikacin , gentamicin , sisomicin , and tobramycin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
111,
120
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
123,
131
]
} |
two hundred and three recent clinical isolates of enterococci were tested for susceptibility to streptomycin , kanamycin , amikacin , gentamicin , sisomicin , and tobramycin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
134,
144
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
147,
156
]
} |
depending upon the source of the isolate , 36 to 54 % of the enterococci demonstrated high-level resistance ( minimal inhibitory concentration , > 2,000 mug/ml ) to streptomycin , 16 to 49 % to kanamycin , and 0 to 14 % to amikacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
194,
203
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
223,
231
]
} |
penicillin , combined with gentamicin , sisomicin , or tobramycin , was synergistic against all 10 strains of streptococcus faecalis subjected to formal testing . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
27,
37
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
40,
49
]
} |
thienamycin and clavulanic acid are new beta-lactam derivatives with structures markedly different from those of penicillins or cephalosporins . | NA | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
40,
51
]
} | {
"id": "C0030842",
"name": "penicillins",
"pos": [
113,
124
]
} |
the in vitro antibacterial activity of cefaclor , cephalothin , and cephalexin against 261 clinical isolates of staphylococcus aureus and enterobacteriaceae was compared . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
39,
47
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
68,
78
]
} |
additional physical abnormalities included patchy alopecia , bilateral zonular cataracts , a depressed nasal bridge , small stature , and multiple skeletal deformities . | NA | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
20,
33
]
} | {
"id": "C0000772",
"name": "multiple",
"pos": [
138,
146
]
} |
the porphyrin-spectrum , as demonstrated by thin-layer-chromatography , showed porphyrins with 2 -- 8 carboxyclic groups , the coproporphyrin standing out in most cases as the most intense band . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
79,
89
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
127,
141
]
} |
four percent ( fifty-nine individuals ) showed some roentgenographic evidence of pneumoconiosis , but only seven miners had films interpreted as cwp of category 2 or greater ( according to the uicc/cincinnati classification system ) . | NA | {
"id": "C0032273",
"name": "pneumoconiosis",
"pos": [
81,
95
]
} | {
"id": "C0003165",
"name": "cwp",
"pos": [
145,
148
]
} |
amino acids alone produced increases in concentration of all the amino acids found in the infusion with the exception of alanine , arginine , and threonine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
0,
11
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
121,
128
]
} |
the differences between human and rat serum were related to the binding characteristics of sulfadimethoxine whereas the differences between human serum and fraction v human serum albumin were attributed to displacement of bilirubin from albumin to other proteins in serum . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
167,
186
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
237,
244
]
} |
the differences between human and rat serum were related to the binding characteristics of sulfadimethoxine whereas the differences between human serum and fraction v human serum albumin were attributed to displacement of bilirubin from albumin to other proteins in serum . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
179,
186
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
254,
262
]
} |
the mode of increase in cell wall polysaccharides of yeast ( glucan and mannan ) during cell cycle was analyzed using cell wall samples obtained from a synchronous culture . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
34,
49
]
} | {
"id": "C0024727",
"name": "mannan",
"pos": [
72,
78
]
} |
in the 4 studied patients presenting with an halasz 's syndrome , the disease was complicated since the neonatal period by pulmonary arterial hypertension and heart failure . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
55,
63
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
70,
77
]
} |
a previous report showed that the group receiving active medication , fluphenazine decanoate and oral fluphenazine , had far fewer relapses ; | NA | {
"id": "C0060580",
"name": "fluphenazine decanoate",
"pos": [
70,
92
]
} | {
"id": "C0016368",
"name": "fluphenazine",
"pos": [
102,
114
]
} |
thus for example under , the influence of epinephrine , norepinephrine , prostaglandine f2 alpha and oxytocine , the tonicity of the vascular system increases and does so the number of spontaneous contractions rather noticeably , particularly under the influence of prostaglandine f2alpha , and under the various catecholamines an increase of frequency and amplitude has been observed . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} |
hepatic vein thrombosis , as well as hepatocellular carcinomas , was induced in inbred c3h male and female mice ingesting 10 ppm of dieldrin , aldrin , heptachlor , or heptachlor epoxide in the diet . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
152,
162
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
168,
186
]
} |
thrombosis was present in 5 % of mice ingesting dieldrin or aldrin and in 10.5 % of mice ingesting heptachlor or heptachlor epoxide . | NA | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
99,
109
]
} | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
113,
131
]
} |
treatment of chick embryo fibroblasts , calf kidney and bhk cells for 30 minutes with the enzyme neuraminidase from vibrio cholerae causes an enhancement of the per cent of attached ndv virions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
26,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
60,
65
]
} |
irradiation 2 days before infection had no effect on the titre of virus in the skin 3 days after infection . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
26,
35
]
} | {
"id": "C0037278",
"name": "skin",
"pos": [
79,
83
]
} |
the morphological picture of this process similar to that in spontaneous regressions of nevuses ( halo-nevus ) , pigmentous spots ( dubreille melanosis ) and superficially spreading melanoma is described . | NA | {
"id": "C0027960",
"name": "nevuses",
"pos": [
88,
95
]
} | {
"id": "C0474824",
"name": "halo-nevus",
"pos": [
98,
108
]
} |
the results of this experiment , namely sacculotomy on hydropic guinea pig ears , suggest that sacculotomy is not a rational procedure for the control of endolymphatic hydrops in meniere 's disease for the following reasons : 1 . | NA | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
154,
175
]
} | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
179,
197
]
} |
these plasmids conferred resistance to gentamicin and sisomycin but not to amikacin or tobramycin , and were inferred to specify the enzyme aminoglycoside 3-n-acetyltransferase ( aac ( 3 ) i or gat i ) . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
39,
49
]
} | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
54,
63
]
} |
gonadal function in both sexes is under the synergistic control of the pituitary gonadotrophins , follicle stimulating hormone ( fsh ) and luteinising hormone ( lh ) which are in turn influenced both by the hypothalamus ( via the gonadotrophin releasing hormone ) and by feedback signals from the gonads . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
71,
80
]
} | {
"id": "C0733758",
"name": "follicle stimulating hormone",
"pos": [
98,
126
]
} |
gonadal function in both sexes is under the synergistic control of the pituitary gonadotrophins , follicle stimulating hormone ( fsh ) and luteinising hormone ( lh ) which are in turn influenced both by the hypothalamus ( via the gonadotrophin releasing hormone ) and by feedback signals from the gonads . | NA | {
"id": "C0018066",
"name": "pituitary",
"pos": [
71,
80
]
} | {
"id": "C0023607",
"name": "luteinising hormone",
"pos": [
139,
158
]
} |
metopyrone , an inhibitor of glucocorticoid synthesis , blocks the development of susceptibility to audiogenic seizures in c57bl/6bg mice after either acoustic priming at 19 days of age or ethanol withdrawal at 70-80 days of age , whereas it has no effect on the development of genetic susceptibility in dba/1bg mice . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
82,
96
]
} | {
"id": "C0314657",
"name": "genetic susceptibility",
"pos": [
278,
300
]
} |
[ differential hemodilution in the left and right ventricle as a diagnostic method for death by drowning ] . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
87,
92
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
96,
104
]
} |
polypeptide analysis on sodium dodecyl sulphate/polyacrylamide gel of labelled kb-cell surface proteins , selected by the different procedures , showed that three major protein subunits of 78000 , 42000 and 34000mol.wt . were common to the three selection systems . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
95,
103
]
} | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
169,
185
]
} |
depletion of cellular cholesterol , by using liposomes of dipalmitoylglycerophosphocholine or phosphatidylcholine from hen erythrocytes , had no effect on the susceptibility of the cells to fusion induced by oleoylglycerol , but markedly decreased fusion induced by sendai virus . | NA | {
"id": "C0000039",
"name": "dipalmitoylglycerophosphocholine",
"pos": [
58,
90
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
94,
113
]
} |
virus-induced cell fusion of guinea-pig erythrocytes , which were enriched in cholesterol by feeding a cholesterol-rich diet to the animals , was also enhanced . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
78,
89
]
} | {
"id": "C0008395",
"name": "cholesterol",
"pos": [
103,
114
]
} |
hydroxy derivatives of monocarboxylate inducers , related mono- and di-carboxylic acids , alcohols , amines , ketones , esters and sulphoxide were ineffective in increasing choriogonadotropin production by hela cells . | NA | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
71,
87
]
} | {
"id": "C0014898",
"name": "esters",
"pos": [
120,
126
]
} |
synthesis of the mating factor of saccharomyces cerevisiae and its truncated peptides : the structure-activity relationship . | NA | {
"id": "C0065743",
"name": "mating factor",
"pos": [
17,
30
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
77,
85
]
} |
these results suggest that genetic factors may be important in determining which nucleic acids antigens become immunogenic , but genetic factors alone do not determine the immunoglobulin class distribution of antibodies to nucleic acids . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
172,
192
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
209,
219
]
} |
etozolin seems to act like a diuretic of the sulfonamide-type in respect to the profile of daily urinary output whereas resembling the loop-diuretic type in respect to urinary volume elimination . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
29,
37
]
} | {
"id": "C0354100",
"name": "loop-diuretic",
"pos": [
135,
148
]
} |
severe typhoid fever that was complicated by multiple intestinal parasitoses ( ascariasis , trichuriasis , giardiasis and strongyloidiasis ) appeared . | NA | {
"id": "C0021832",
"name": "intestinal",
"pos": [
54,
64
]
} | {
"id": "C0017536",
"name": "giardiasis",
"pos": [
107,
117
]
} |
cystinuria is a disease characterized by the excessive elimination of cystine and of dibasic amino acids ( lysine , arginine , and ornithine ) through urine of homozygotes . | NA | {
"id": "C0010682",
"name": "cystine",
"pos": [
70,
77
]
} | {
"id": "C0002523",
"name": "dibasic amino acids",
"pos": [
85,
104
]
} |
tilorone hydrochloride , a drug able selectively to affect t-lymphocyte fuction , when incorporated ( at three different concentrations 0.1 , 0.04 , 0.02 microgram/ml ) in lymphocyte culture , stimulated by 50 microgram/ml of e. coli lps ( 026 : b6 w ) , is able to abolish lif production , due to endotoxin stimulation . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
234,
237
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
298,
307
]
} |
the mean doses of phenobarbitone , methylphenobarbitone and primidone which produced the same plasma phenobarbitone level ( 15 microgram/ml ) were , respectively , 1.75,2.75 and 7.75 mg kg-1 day-1 . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
18,
32
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
60,
69
]
} |
2 the lower limit of sensitivity for this method is 25 pg for adrenaline and 30 pg for noradrenaline/ml of plasma . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
62,
72
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
87,
100
]
} |
in 3 cases of localized primary amyloidosis of the skin highly active cells were demonstrated , showing grossly dilated cisternae of rough endoplasmic reticulum , resembling fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
70,
75
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
circulating levels of pregnancy-specific beta1-glycoprotein and human placental lactogen in the third trimester of pregnancy : their relationship to parity , birth weight , and placental weight . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
158,
170
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
187,
193
]
} |
titration of the oxidizing power of dpc formed with h2o2 implies that submaximal yields of dpc are obtained , a result that could implicate dpc species as analogues of catalase compound i in the catalase action of ferrihemes . | NA | {
"id": "C0020281",
"name": "h2o2",
"pos": [
52,
56
]
} | {
"id": "C0031180",
"name": "dpc",
"pos": [
140,
143
]
} |
the immunization of rabbits with purified guinea pig liver transglutaminase resulted in the appearance of two antibody populations against the enzyme : one which reacted only with the ca2+-enzyme complex and another which reacted with the intact as well as the ca2+-enzyme . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
189,
203
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
266,
272
]
} |
without this treatment , numerous acid-soluble tail proteins coextract with the nuclear proteins isolated from partially purified heads . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
80,
96
]
} |
the second polypeptide is less basic than s20 , but exhibits all the structural and functional properties of a precursor to s20 , including the presence of an additional methionine residue , apparently as n-formylmethionine . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
170,
180
]
} | {
"id": "C0027228",
"name": "n-formylmethionine",
"pos": [
205,
223
]
} |
the observed change in the relative amounts of two nonallelic variants of a histone coincident with changes in the physiologic states of the cell may indicate a correlation between genome structure and function . | NA | {
"id": "C0025320",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C2916830",
"name": "physiologic states",
"pos": [
115,
133
]
} |
the order of reactivity was found to be thymine greater than uracil greater than cytosine greater than guanine greater than adenine . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
40,
47
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
61,
67
]
} |
furthermore one of the two mitochondrial trnas that we had earlier demonstrated to be directly charged with glutamic acid responds to glutamine but not to glutamic acid codons . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
134,
143
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
155,
168
]
} |
we argue that much of the ion release results from the displacement of cations from the dna , and estimate on this basis that 12 +/- 2 phosphates are involved in ionic interactions with the protein . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
71,
78
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
162,
167
]
} |
peptide analyses after inactivation with [ 1-14c ] vinylglycine showed that vinylglycine alkylates the active-site lysine residue 258 which forms the internal aldimine with the coenzyme pyridoxal 5'-phosphate . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
177,
185
]
} | {
"id": "C0034266",
"name": "pyridoxal 5",
"pos": [
186,
197
]
} |
the protein is relatively rich in lysine , glycine , alanine , and valine which together comprise about 60 % of the total amino acid residues . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
43,
50
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
122,
132
]
} |
the protein is relatively rich in lysine , glycine , alanine , and valine which together comprise about 60 % of the total amino acid residues . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
53,
60
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
122,
132
]
} |
equilibrium constants for hydration of ketones , in dilute d2o solution at 34 degrees c , observed by proton magnetic resonance under conditions of slow exchange , were acetone 0.002 , chloroacetone 0.08 , 1,3-dichloroacetone 4.17 , bromoacetone 0.07 , and 1,3-dibromoacetone ( an inhibitor of papain ) 1.85 . | NA | {
"id": "C0022634",
"name": "ketones",
"pos": [
39,
46
]
} | {
"id": "C0001002",
"name": "acetone",
"pos": [
268,
275
]
} |
thus the serine proteases , subtilisin and those of the chymotrypsin family , are of one hand while the cysteine enzymes , glyceraldehyde-3-phosphate dehydrogenase and papain , are of the other . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
9,
25
]
} | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
28,
38
]
} |
thus the serine proteases , subtilisin and those of the chymotrypsin family , are of one hand while the cysteine enzymes , glyceraldehyde-3-phosphate dehydrogenase and papain , are of the other . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
9,
25
]
} | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
56,
68
]
} |
swelling of rat liver mitochondria induced by various neutral amino acids indicates that the l isomers of serine , alanine , methionine , valine , threonine , and leucine enter the mitochondrial matrix by a stereospecific process . | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
54,
73
]
} | {
"id": "C0036720",
"name": "serine",
"pos": [
106,
112
]
} |
glycine , d- or l-serine , l-threonine , l-methionine , l-alanine , and l-valine all individually protected against the inactivation of glycine , l-serine , l-threonine , l-methionine , l-alanine , l-valine , l-proline , and beta-alanine transport , while l-proline , beta-alanine , | NA | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
56,
65
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
268,
280
]
} |
furthermore , these proteins were shown to have a higher affinity for poly ( a+ ) rna as compared with rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
82,
85
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
103,
107
]
} |
the large ribosomal subunits of rat liver contain small amount of minor rna components which migrate through polyacrylamide gels between the two major rrnas , and some 28 s rrna molecules contain hidden nicks which can be revealed by heat treatment . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
72,
75
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
173,
177
]
} |
the hybridization-competition experiments with 28 s rna established that the minor rna components and 28 s rrna have a common dna origin . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
52,
55
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
107,
111
]
} |
when rna components were isolated from rats that had received [ 14c ] orotate and [ 3h ] orotate , 1 week and 16 h , respectively , before sacrifice , the 14c : 3h ratio was the highest in the minor components , followed by the nicked rna , and the intact 28 s rrna showed the lowest ratio . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
5,
8
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
261,
265
]
} |
[ 35s ] methionine became incorporated into both the large and small subunits of fraction i protein , the major soluble protein of chloroplasts . | NA | {
"id": "C0599220",
"name": "subunits",
"pos": [
69,
77
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
120,
127
]
} |
the activity was assayed with both glutathione disulfide ( gssg ) and the mixed disulfide of coenzyme a and glutathione ( coassg ) . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
59,
63
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
108,
119
]
} |
hypoxanthines , bearing at position 8 aryl or pyridyl substituents , are converted by bovine milk xanthine oxidase ( xanthine : oxygen oxidoreductase , ec 1.2.3.2 ) into the corresponding xanthines at low rates . | NA | {
"id": "C0043314",
"name": "xanthine",
"pos": [
4,
12
]
} | {
"id": "C0043318",
"name": "xanthines",
"pos": [
188,
197
]
} |
the cationic substrates are attracted to the enzyme by an anionic group , which probably forms an ion pair with a protonated amino group in or near the active center . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
4,
12
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
98,
101
]
} |
the cationic substrates are attracted to the enzyme by an anionic group , which probably forms an ion pair with a protonated amino group in or near the active center . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
58,
65
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
98,
101
]
} |
pure ascorbate oxidase ( l-ascorbate : oxygen oxidoreductase , ec 1.10.3.3 ) isolated from cucurbita pepo medullosa , which is known to be specific for ascorbic acid , shows a secondary catecholoxidase activity at approx . | NA | {
"id": "C0003967",
"name": "ascorbate oxidase",
"pos": [
5,
22
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
63,
67
]
} |
prolyl hydroxylase ( proline,2-oxoglutarate dioxygenase , ec 1.14.11.2 ) of soluble fraction ( 105 000 x g supernatant ) of rat granulation tissues was markedly enhanced by addition of nucleoside triphosphates to the assay medium . | NA | {
"id": "C3665675",
"name": "prolyl hydroxylase",
"pos": [
0,
18
]
} | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
44,
55
]
} |
histidine c-2 proton resonances in rhesus monkey carbonic anhydrase b ( carbonate hydro-lyase , ec 4.2.1.1 ) and bovine carbonic anhydrase were investigated using 270-mhz proton magnetic resonance . | NA | {
"id": "C0007033",
"name": "carbonic anhydrase b",
"pos": [
49,
69
]
} | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
120,
138
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.