text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
resonances from solvent exchangeable protons have been observed in the 11-16 ppm range in the nmr spectra of human carbonic anhydrases b and c and bovine carbonic anhydrase . | NA | {
"id": "C0007033",
"name": "carbonic anhydrases b",
"pos": [
115,
136
]
} | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
154,
172
]
} |
aconitase ( citrate ( isocitrate ) hydro-lyase , ec 4.2.1.3 ) prior to activation demonstrates a single binding site for substrates and inhibitors . | NA | {
"id": "C0001156",
"name": "aconitase",
"pos": [
0,
9
]
} | {
"id": "C0020239",
"name": "hydro-lyase",
"pos": [
35,
46
]
} |
low molecular weight acid phosphatase ( orthophosphoric monoester phosphophydrolase ( acid optimum ) , ec 3.1.3.2 ) from bovine brain is activated up to 4-fold by guanosine , guanine , adenine , adenosine , and 6-ethylmercapto-purine . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
185,
192
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
227,
233
]
} |
the labelled ( na+ +k+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) , although reversibly inhibited , was capable of undergoing conformational changes associated with the active enzyme that could be monitored fluorometrically . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
15,
17
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
35,
55
]
} |
human erythrocyte hexokinase ( atp : d-hexose 6-phosphotransferase , ec 2.7.1.1 ) was inhibited competitively with respect to mgatp2- by glucose-6-p ( ki - 10.8 mum ) and fructose-6-p ( ki = 160 mum ) . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
39,
45
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
171,
179
]
} |
analogues of 1-palmitoyl-sn-glycero-3-phosphorylcholine were used to ascertain the respective roles of the 1-palmitoyl-sn-glycero and choline groups in binding this substrate to the transferase catalyzing the acylation reaction . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
38,
55
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
134,
141
]
} |
95 % of the total recovered gangliosides were hematosides ( gm3 ) , which migrated as three major species . | NA | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
28,
40
]
} | {
"id": "C0016897",
"name": "hematosides",
"pos": [
46,
57
]
} |
the three hematoside gangliosides appeared to differ on the basis of their fatty acid composition . | NA | {
"id": "C0016897",
"name": "hematoside",
"pos": [
10,
20
]
} | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
21,
33
]
} |
hydrogen-deuterium exchange kinetics of ( asn1-val5 ) angiotensin ii has been investigated by proton magnetic resonance at 250 mhz in deuterated trifluoroethanol , as an approach to the `` '' in situ '' '' hormone conformation . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
0,
8
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
9,
18
]
} |
analysis of the major protein component of the extract of plaque areas indicated an acidic glyco-protein which appeared to be associated with an organic phosphorous moiety as well as cholesterol and cholesterol esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
183,
194
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
199,
217
]
} |
the oxygen affinity of hb sawara was shown to be increased , the difference of the log p50 value between normal and abnormal hemoglobins being 0.37 at ph 7.0 . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
23,
25
]
} | {
"id": "C0019047",
"name": "abnormal",
"pos": [
116,
124
]
} |
the protein obtained by two purification steps , batchwise adsorption with deae-cellulose followed by chromatography on cm-cellulose , was proved to be native alpha1-acid glycoprotein in a high degree of purity by electrophoretical , immunological , ultracentrifugal and carbohydrate analysis . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
75,
89
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
123,
132
]
} |
the effects of colchicine on release of milk lipids from mammary tissue were evaluated by biochemical analysis of milk and morphological study of the tissue following intramammary infusions of the alkaloid into lactating goats . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
15,
25
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
197,
205
]
} |
the 3h/14c ratio found in n-methyl-l-glucosamine further supports a mechanism that the conversion of d-glucose to l-hexose is carried out without scission of carbon skeleton . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
103,
110
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
116,
122
]
} |
it was stated by chemoluminescence methods that these ions induce slow developed oxidative radical chain reaction in lipid cell membranes and break the lipoprotein bonds . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
117,
122
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
152,
163
]
} |
the quenching efficiency of the chlorophylls increases with reduction of the semiisolated double bonds , reduction of these bonds in molecules of the pheophytins decreases the constants of the quenching . | NA | {
"id": "C0008260",
"name": "chlorophylls",
"pos": [
32,
44
]
} | {
"id": "C0031512",
"name": "pheophytins",
"pos": [
150,
161
]
} |
it is suggested that differences in lpo kinetics in prm of walleye pollack and frog are caused by the differences in the lipid composition of the membranes ( primarily by a high level of phospholipid molecular species with two unsaturated fatty acid residues in walleye pollock retina rod outer segments ) . | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
121,
126
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
187,
199
]
} |
multiple molecular forms of subtilisin -- extracellular serine protease produced by the wild strain bac . subtilis a-50 and its mutant strains with the protease activity decreased two-fold and more were studied . | NA | {
"id": "C0038601",
"name": "subtilisin",
"pos": [
28,
38
]
} | {
"id": "C0036734",
"name": "serine protease",
"pos": [
56,
71
]
} |
it was found that the enzyme from these sources exists in the form of three isoenzymes , the main izoenzyme being the most basic form . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
22,
28
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
76,
86
]
} |
the glucone site is capable to bind glucose and mannose , whereas the aglucone one- some compounds whose affinity for the enzyme may be expressed as follows : glucose greater than galactose greater than paranitrophenol greater than or equal to glycerol greater than ethanol approximately equal to methanol . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
266,
273
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
297,
305
]
} |
peptids , lipids and carbohydrates `` '' firmly '' '' associated with the protein part of membrane lipoproteins were found at all stages of chloroplast ultrastructure formation . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
10,
16
]
} | {
"id": "C0023820",
"name": "lipoprotei",
"pos": [
99,
109
]
} |
the protective effect of alpha-tocopherylacetate , tocopherilquinones and partially of alpha-tocopherol is due to a stabilizing effect of these compounds on sarcoplasmic reticulum membranes , registered by a decrease of fluidity of membrane lipid bilayer ( probed by nitroxile radical tempo ) and by a decrease of its passive permeability for ca2+ . | NA | {
"id": "C1999896",
"name": "alpha-tocopherylacetate",
"pos": [
25,
48
]
} | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
87,
103
]
} |
the ratio between the isoenzyme content of the two enzymes from the cytoplasmic fraction of regenerating liver varied as compared to normal . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
22,
31
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
51,
58
]
} |
these data are discussed in terms of the quantitative effect of ionic strength on the kinetics of helix-coil transitions in oligo- and polynucleotides . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
124,
129
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
135,
150
]
} |
vibrational modes of a-dna , b-dna , and a-rna backbones : an application of a green-function refinement procedure . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0919262",
"name": "b-dna",
"pos": [
29,
34
]
} |
the hydroperoxy and several alkylthio derivatives of the antitumor agents cyclophosphamide ( 2-bis ( 2-chloroethyl ) amino tetrahydro-2h-1,3,2-oxazaphosphorine 2-oxide ) , ifosfamide ( 3- ( 2-chloroethyl ) -2- ( 2-chloroethylamino ) tetrahydro-2h-1,3,1-oxazaphosphorine 2-oxide ) and trofosfamide ( 3- ( 2-chloroethyl ) -2- ( bis ( 2-chloroethyl ) amino ) tetrahydro-2h-1,3,2-oxazaphosphori ne 2-oxide ) were characterized by electron impact and field desorption mass spectrometry . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
74,
90
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
172,
182
]
} |
the compounds , which are stabilized derivatives of the activated hydroxylated intermediates of cyclophosphamide ( ifosfamide , trofosfamide ) , could be identified as 4-hydroperoxy and 4-alkylthio oxazaphosphorines . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
96,
112
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
115,
125
]
} |
derivatives of prostaglandin f 2alpha and f 3alpha are difficult to separate by gas chromatography , so that the use of this ion type for single ion monitoring of either prostaglandin ( as has been reported ) is ambiguous . | NA | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
15,
30
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
170,
183
]
} |
a comparative study of the effect of some benzodiazepine deprivatives ( chlonazepam , lorazepam , diazepam , and medazepam ) on the recovery cycles of the interzonal response was carried out on unanesthetized curare-immobilized cats . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
42,
56
]
} | {
"id": "C0025051",
"name": "medazepam",
"pos": [
113,
122
]
} |
following clotting factor assays were performed on the fluid of burn blisters of 11 patients with severe burns : fibrinogen levels , factor ii , v , x and xiii , thrombin time , fibrin split products , plasminogen , antithrombin iii , iga , igm , igg , ethanol gelation test and total proteins . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
10,
25
]
} | {
"id": "C0033706",
"name": "factor ii",
"pos": [
133,
142
]
} |
classical mycosis fungoides and sezary syndrome are part of a larger spectrum of cutaneous t cell lymphomas . | NA | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
32,
47
]
} | {
"id": "C0079773",
"name": "of",
"pos": [
78,
80
]
} |
1 the cardiovascular responses to dimaprit ( s- ( 3-dimethylaminopropyl ) isothiourea ) a selective histamine h2-receptor agonist have been studied in anaesthetized cats , dogs , rats and rabbits . | NA | {
"id": "C0058185",
"name": "dimaprit",
"pos": [
34,
42
]
} | {
"id": "C0039958",
"name": "isothiourea",
"pos": [
74,
85
]
} |
1 the problem of whether locally released noradrenaline can be methylated to adrenaline in the hypothalamus has been investigated . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
42,
55
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} |
these results suggest that noradrenaline released during activity of noradrenergic hypothalamic structures may be methylated to adrenaline in the hypothalamus . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
128,
138
]
} |
studies of hydrolytic enzymes and isoenzymes of normal and neoplastic childhood renal tissues and their tissue cultured cells . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
22,
29
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
34,
44
]
} |
after fertilization , free arginine and creatine decrease , within respect to unfertilized eggs , whereas phosphocreatine undergoes a large increase ; | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
40,
48
]
} | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
106,
121
]
} |
a soluble nondialyzable polymer of glucose was isolated and purified by selective ethanol and ammonium sulfate precipitation from the supernatant of a culture of acetobacter xylinum which was actively producing cellulose . | NA | {
"id": "C0017696",
"name": "polymer",
"pos": [
24,
31
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
211,
220
]
} |
in addition , the patient had muscle weakness and pain , headaches , episodic hypertension , myoglobinuria , acute renal failure and anemia . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
50,
54
]
} | {
"id": "C0018681",
"name": "headaches",
"pos": [
57,
66
]
} |
in 26 ( 16 % ) of 160 cases of non-hodgkin 's lymphoma , the initial interpretation of pattern ( nodular vs diffuse ) differed : 20 ( 25 % ) of 81 nodular lymphomas had been thought to be diffuse and 6 ( 8 % ) of 79 diffuse lymphomas had been diagnosed as nodular . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
31,
54
]
} | {
"id": "C0024301",
"name": "nodular lymphomas",
"pos": [
147,
164
]
} |
isolated ( 1 leads to 3 ) -alpha-d-glucosidic linkages that occur in mycodextran , isolichein , dextrans , and oligosaccharides derived from dextran were not hydrolysed . | NA | {
"id": "C0011806",
"name": "dextrans",
"pos": [
96,
104
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
141,
148
]
} |
a very limited number of discrete rabbit dna fragments was found which could form well matched hybrids with pbetag1 dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
116,
119
]
} |
transcription at two heat shock loci in drosophila melanogaster , in subdivisions 87a and 57c , was investigated by hybridization in situ with 3h-labeled messenger , nuclear rna and whole cell rna from cells cultured at elevated temperature . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
166,
177
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
193,
196
]
} |
isoelectric focusing indicated that the myosin heavy chain synthesized in vitro contained two chains in equal amounts , as did purified embryonic leg skeletal muscle myosin . | NA | {
"id": "C0027100",
"name": "myosin heavy",
"pos": [
40,
52
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
166,
172
]
} |
sds-urea polyacrylamide gel electrophoresis of mouse milk proteins revealed the presence of three major phosphoproteins ( caseins ) of m.w . | NA | {
"id": "C0026138",
"name": "milk proteins",
"pos": [
53,
66
]
} | {
"id": "C0007332",
"name": "caseins",
"pos": [
122,
129
]
} |
by using an antiserum against crude casein fraction , an immunoprecipitation method was developed for the quantitative measurement of the rate of milk protein synthesis in the mouse mammary tissue . | NA | {
"id": "C0007332",
"name": "casein",
"pos": [
36,
42
]
} | {
"id": "C0026138",
"name": "milk protein",
"pos": [
146,
158
]
} |
rna synthesized in vitro by calf thymus rna polymerase iii ( c ) , as well as by e. coli rna polymerase , is restricted to a subset of calf thymus dna . | NA | {
"id": "C0035680",
"name": "rna polymerase iii",
"pos": [
40,
58
]
} | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
89,
103
]
} |
a greater portion of rna transcribed from dna by rna polymerase iii hybridizes to moderately repeated dna than rna transcribed by escherichia coli rna polymerase . | NA | {
"id": "C0035680",
"name": "rna polymerase iii",
"pos": [
49,
67
]
} | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
147,
161
]
} |
these results suggest : 1 ) rna polymerase iii may be responsible for the synthesis of rna species in addition to trna and 5 s ribosomal rna and a portion of this rna is transcribed from unique dna ; | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
127,
140
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
163,
166
]
} |
and 2 ) in vitro there may be selectivity in the initiation of transcription by both e. coli rna polymerase and calf thymus rna polymerase iii . | NA | {
"id": "C0035681",
"name": "rna polymerase",
"pos": [
93,
107
]
} | {
"id": "C0035680",
"name": "rna",
"pos": [
124,
127
]
} |
measurements of sedimentation of mixed dispersions of monocarboxylic lecithins and glutaryl-lecithins show that glutaryl-lecithins must be in the form of micelles to solubilize the phosphatidyl cholines . | NA | {
"id": "C0031617",
"name": "lecithins",
"pos": [
69,
78
]
} | {
"id": "C1959616",
"name": "phosphatidyl cholines",
"pos": [
181,
202
]
} |
the synthesis of cytokinins in isolated roots of lupinus albus l. cultured under sterile conditions , seems to be induced by leaf proteins and lectins extracted from the cotyledons . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
130,
138
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
143,
150
]
} |
immunochemical methods have been used to prove that the leaf proteins were lectins too , quite different from those coming from cotyledons , but having the same effect on the root cytokinins synthesis . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
61,
69
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
75,
82
]
} |
the active transport of ammonia gas was obtained with an asymmetric composite membrane-model using h+ as carrier and the formation of water as chemical energy source . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
24,
31
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
32,
35
]
} |
the experimental molecular pump externally limited by two silicone films permeable to gasses but not to liquids or ions is separated into two liquid layers by a central cation-exchange membrane . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
115,
119
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
169,
175
]
} |
in the anterior pituitary of alytes obstetricans tadpoles in premetamorphic stages , two cell types were localized by cytoimmunological techniques : orangeophilic cells secreting a prolactin-like hormone in the anterior and median region and erythrosinophilic cells secreting growth hormone in a more caudal situation . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
7,
25
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
276,
290
]
} |
blood cyanide and plasma nitroprusside concentrations were measured when sodium nitroprusside was infused into a baboon . | NA | {
"id": "C0028193",
"name": "nitroprusside",
"pos": [
25,
38
]
} | {
"id": "C0037533",
"name": "sodium nitroprusside",
"pos": [
73,
93
]
} |
we describe a new method for determination of thrombin-clottable fibrinogen , which eliminates the systematic error caused by occlusion of other serum proteins in the fibrin clot and reduces the sensitivity to high concentrations of fibrin degradation products . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
65,
71
]
} | {
"id": "C0163275",
"name": "fibrin degradation products",
"pos": [
233,
260
]
} |
a single-tube radioimmunoassay for both cholic acid and chenodeoxycholic acid conjugates in serum is based on the use of [ 1- ( 14 ) c ] glycocholic acid and [ h-3h ] glycochenodeoxycholic acid as tracers . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
56,
77
]
} | {
"id": "C0017903",
"name": "glycochenodeoxycholic acid",
"pos": [
167,
193
]
} |
two methods for measuring plasma alkaline phosphatase activity are compared : one makes use of phenyl phosphate , carbonate-bicarbonate buffer , and continuous-flow methodology ; | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
114,
123
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
124,
135
]
} |
the urine sample , 4-aminoantipyrine in carbonate-bicarbonate buffer , and potassium ferricyanide solution are mixed and the quinoneimine dye that forms is measured at 500 nm . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
40,
49
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
50,
61
]
} |
we have shown that creatine kinase z is rather unstable in nature , and converts to a form which electrophoreses with creatine kinase mm on agarose gel electrophoresis . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
19,
34
]
} | {
"id": "C0010291",
"name": "creatine kinase mm",
"pos": [
118,
136
]
} |
particularly bivalent cations and anions with a strong chaotropic effect ( scn- , i- and clo4- ) were found to influence strongly the specific immunological reaction . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
34,
40
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
162,
163
]
} |
semi-automated measurement of urinary catecholamines , specific for dopa , noradrenaline , adrenaline and dopamine and other metabolites has been developed . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
91,
101
]
} |
concentrations of the major lipid and lipoprotein classes were higher in the users , but the elevation was statistically significant only in the case of the high density lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
28,
33
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
170,
181
]
} |
while the electrophoretic behaviour , the protein-lipid and apoprotein composition of pig lp-x were comparable to those found in man , dog and rat , it sedimated in most instances at the density 1.063 g/ml . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
42,
49
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
60,
70
]
} |
incubation of erythrocytes , with a decreased gsh/gssg ratio , resulted in an increase in [ s ] 0.5 of pyruvate kinase of phosphoenolpyruvate as measured in haemolysates . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
46,
49
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
50,
54
]
} |
the apparent affinity of pyruvate kinase for phosphoenolpyruvate returned to normal when the gssg formed was reduced to gsh intracellularly . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
93,
97
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
120,
123
]
} |
however , that a decreased gsh/gssg ratio can be a single cause of acquired pyruvate kinase deficiency seems highly improbable . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
27,
30
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
31,
35
]
} |
blood glucose was determined by both oxygen consumption rate during glucose oxidation and the ferricyanide method . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
68,
75
]
} |
the coefficient of variation of blood glucose ratios ( glucose at time x/fasting glucose ) by glucose oxidase varied considerably . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
32,
45
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
94,
101
]
} |
tolbutamide half-life was increased by chronic administration of sulfaphenazole ( 9.5 hr to 28.6 hr , n = 2 ) , phenylbutazone ( 7.9 hr to 23.1 hr , n = 8 ) , and oxyphenbutazone ( 8.1 hr to 30.2 hr , n = 2 ) . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
112,
126
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
163,
178
]
} |
in contrast , phenylbutazone and oxyphenbutazone , administered as single oral doses of 800 mg , had no immediate effect on tolbutamide elimination . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
14,
28
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
33,
48
]
} |
it is suggested that phenylbutazone and oxyphenbutazone act by inducing form of cytochrome p-450 with low activity for tolbutamide hydroxylation , whereas sulfaphenazole acts by direct inhibition of the microsomal mixed function oxidase system . | NA | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
21,
35
]
} | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
40,
55
]
} |
it is suggested that phenylbutazone and oxyphenbutazone act by inducing form of cytochrome p-450 with low activity for tolbutamide hydroxylation , whereas sulfaphenazole acts by direct inhibition of the microsomal mixed function oxidase system . | NA | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
80,
96
]
} | {
"id": "C0003927",
"name": "microsomal mixed function oxidase",
"pos": [
203,
236
]
} |
numerous chemical toxins , including normal components of natural foods , e.g. , mycotoxins , and toxic chemicals as contaminants such as pesticides , fertilizers , food additives , and preservatives , which are potentially toxic to humans , are discussed . | NA | {
"id": "C0040549",
"name": "toxins",
"pos": [
18,
24
]
} | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
81,
91
]
} |
the construction of a preliminary pharmacokinetic model for the distribution , long-term storage sites , excretion , and metabolism of selected polychlorinated biphenyls ( pcbs ) in the rat is described . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
105,
114
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
121,
131
]
} |
the initial blood pressure response to saralasin ( sar1-ala8-angiotensin ii ) infusion was examined in 15 normal subjects , eight patients with untreated essential hypertension and 65 patients established on chronic haemogialysis ( including six anephric patients ) , and related to measurements of plasma renin activity ( pra ) , angiotensin ii , plasma catecholamines ( noradrenaline and adrenaline ) , blood volume and extracellular fluid volume ( [ 35s ] sulphate space or exchangeable sodium ) . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
39,
48
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
331,
345
]
} |
the initial blood pressure response to saralasin ( sar1-ala8-angiotensin ii ) infusion was examined in 15 normal subjects , eight patients with untreated essential hypertension and 65 patients established on chronic haemogialysis ( including six anephric patients ) , and related to measurements of plasma renin activity ( pra ) , angiotensin ii , plasma catecholamines ( noradrenaline and adrenaline ) , blood volume and extracellular fluid volume ( [ 35s ] sulphate space or exchangeable sodium ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
372,
385
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
390,
400
]
} |
in the normal subjects , saralasin infusion resulted in a significant rise in plasma noradrenaline ( mean increase 360 % , p less than 0-02 ) without change in plasma adrenaline concentration . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
85,
98
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
167,
177
]
} |
an increase in plasma noradrenaline also occurred in dialysis patients ( p less than 0-005 ) but the change in mean blood pressure with saralasin in this group was inversely related to pra ( p less than 0-001 ) and angiotensin ii ( p less than 0-001 ) , directly related to blood volume ( p less than 0-001 ) , but unrelated to the change in plasma noradrenaline . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
136,
145
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
215,
229
]
} |
21 percent of the interviewees were aware of their having dental calculus and 46 percent had the impression that they had never had calculus . | NA | {
"id": "C0011330",
"name": "dental",
"pos": [
58,
64
]
} | {
"id": "C0006736",
"name": "calculus",
"pos": [
132,
140
]
} |
the findings in a patient with surgically proven lutembacher 's syndrome ( coexisting mitral stenosis and atrial septal defect ) are presented . | NA | {
"id": "C0024164",
"name": "lutembacher 's syndrome",
"pos": [
49,
72
]
} | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
106,
126
]
} |
dmae was tried because of reports of reduction of chorea , and other dyskinesias with this drug . | NA | {
"id": "C0008489",
"name": "chorea",
"pos": [
50,
56
]
} | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
69,
80
]
} |
among 291 persons of all age groups from cologne or frankfurt and environs who had been in contact with golden hamsters there were 17 ( 5.8 % ) with neutralizing antibodies against lymphocytic choriomeningitis ( lcm ) , while such antibodies were present in only 5 ( 2 % ) of 251 persons without such contact , the difference between antibody rates representing a probability of error of 5 % lcm-virus infections caused by golden hamsters occurred also in city dwellers , younger age groups and more females than has been previously the case , confirming an increased risk through contact with pet hamsters . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
149,
161
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
334,
342
]
} |
there was a significant decrease in thrombo-embolism in the heparin/dhe group ( 8.7 % deep-vein thrombosis ; 2.7 % pulmonary embolism ) compared with the heparin group ( 19.8 % and 5.5 % , respectively ) and the control group ( 30 % and 14 % , respectively ) . | NA | {
"id": "C0013922",
"name": "embolism",
"pos": [
44,
52
]
} | {
"id": "C0034065",
"name": "pulmonary embolism",
"pos": [
115,
133
]
} |
the antibody-antidiuretic hormone immune complexes which may interfere with the action of the endogenous vasopressin on the kidney were found in the diabetes insipidus rabbits . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
34,
40
]
} |
the antibody-antidiuretic hormone immune complexes which may interfere with the action of the endogenous vasopressin on the kidney were found in the diabetes insipidus rabbits . | NA | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
13,
33
]
} | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
105,
116
]
} |
major neutral lipid fractions of the preputial glands of mice have been identified by analytical and preparative thin layer chromatography ( tlc ) and gas liquid chromatography ( glc ) as wax esters , neutral plasmalogen , alkyl diglyceride , triglyceride and cholesterol . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
14,
19
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
188,
191
]
} |
an unusual lipid fraction between wax esters and neutral plasmalogens was identified as alkyl acetate , which has been reported earlier to function as sex attractant . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
11,
16
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
34,
37
]
} |
three unknown bands of lipids were identified by tlc between wax ester and alk-1-enyl diglycerides , which on further analysis by glc and infrared spectroscopy gave preliminary indication of aliphatic diester waxes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
23,
29
]
} | {
"id": "C0043076",
"name": "waxes",
"pos": [
209,
214
]
} |
isolated pancreatic islets of these two groups of sand rats were incubated with [ 3h ] -leucine to study the incorporation of this amino acid into proinsulin and insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
147,
157
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
162,
169
]
} |
tissues were homogenized and aqueous , lipid , and protein-nucleoprotein fractions were separated for quantification of radioactivity . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
51,
58
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
59,
72
]
} |
these results strongly suggest the existence of a direct transfer process of rna polymerase to heparin , bypassing the rate-limiting step of dissociation of the enzyme - dna complex to free enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
161,
167
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
190,
196
]
} |
ribosomal proteins previously inactivated by treatment with fluorescein isothiocyanate have been incorporated into 50-s ribosomal subunits during reconstitution from particles disassembled by 2 m licl in the presence of an excess of the modified proteins . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
0,
18
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
246,
254
]
} |
on the basis of radiospectroscopy , methylation analysis , smith degradation , and chromium trioxide oxidation , the repeating oligosaccharide unit of the polysaccharide can be assigned the following structure : ( formula : see text ) where glcnac is 2-acetamido-2-deoxy-d-glucopyranose , manp is mannopyranose , rhalca is rhammolacytic acid and ac is an acetyl group . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
127,
142
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
155,
169
]
} |
membrane proteins except for a pair of major outer membrane proteins ( proteins ia and ib ) were found to be solubilized effectively by lysis buffer containing urea , triton x-100 , ampholines and 2-mercaptoethanol . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
0,
17
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
71,
79
]
} |
it is suggested that the inhibitory effect of pyruvate is due to its competition with nadh for binding to the free enzyme and formation of an inactive enzyme-pyruvate binary complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
115,
121
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
151,
157
]
} |
the kinetics of hydrogen-deuterium exhcange in the polypeptide chain elongation factor tu ( ef tu ) from escherichia coli and that from thermus thermophilus hb8 has been examined in aqueous solutions at various ph and temperatures by means of infrared absorption measurements . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
16,
24
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
25,
34
]
} |
the polysaccharide and oligosaccharides obtained from it were subjected to methylation and chromic acid oxidation . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
4,
18
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
23,
39
]
} |
it occurs only under conditions permitting atp dephosphorylation and it proceeds as long as enzyme molecules are permitted to enter the enzyme - dna complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
92,
98
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
136,
142
]
} |
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