text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it is argued that chain separation starts near a single-stranded dna region and that , forced by continued adsorption of enzyme molecules to the dna , it develops along the duplex . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
49,
68
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
145,
148
]
} |
beta-glucuronidase deficiency in fibroblasts , leucocytes and in serum and increased urinary excretion of mucopolysaccharides were found in a girl , now 13 years old , who exhibits some features of a mucopolysaccharidosis such as moderate mental deficiency , craniofacial dysmorphism , a short neck , protruding sternum , vertebral deformities and corneal clouding . | NA | {
"id": "C0085132",
"name": "beta-glucuronidase deficiency",
"pos": [
0,
29
]
} | {
"id": "C0026703",
"name": "mucopolysaccharidosis",
"pos": [
200,
221
]
} |
hydroxyproline was determined under conditions of a very low proline diet and 1.5 liters of daily fluid intake . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
0,
14
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
61,
68
]
} |
the following questions are asked : is it not possible that there is only one adrenoceptor whose specific agonists are epinephrine or norepinephrine ? | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
134,
148
]
} |
the content of the free fatty acids , ketone bodies , total glycogen , glucose , adrenaline and noradrenaline and morpho-histochemical picture of the tissues of neuro-endocrinal system ( hypophysis and adrenal ) in the brain , heart , liver , skeletal muscles and blood of the white non-linear rats , were studied 2-3 min adaptation to complex atmosphere changes : gradual increase of the co2 , decrease of the o2 , and cooling ( in the condition of deep hypothermia the rectal temperature was -- rt -- 19.1 +/- 0.1 degrees c ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
81,
91
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} |
specific autoantibodies of neutralizing character to histamine , serotonin , kallikrein , bradykuinine , acetylcholine , adrenalin , noradrenalin , insulin , and to the serotonin metabolite -- 5-hydroxyindolacetic acid , were found in donor serum ( 47.2 % ) and in intact rabbits , guinea pigs , rats , and mice ( 24.4 % ) . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
121,
130
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
133,
145
]
} |
[ an improved method for the simultaneous analysis of norepinephrine , epinephrine and dopamine at the picogram level by mass fragmentography ( author 's transl ) ] . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
54,
68
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
71,
82
]
} |
both biguanides effectively reduced the fasting blood sugar and body weight of the patients , metformin apparently having a greater effect on blood sugar than phenformin . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
5,
15
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
94,
103
]
} |
both biguanides effectively reduced the fasting blood sugar and body weight of the patients , metformin apparently having a greater effect on blood sugar than phenformin . | NA | {
"id": "C0005382",
"name": "biguanides",
"pos": [
5,
15
]
} | {
"id": "C0031404",
"name": "phenformin",
"pos": [
159,
169
]
} |
strontium ions as a probe for the role of alkaline-earth metal ions in histamine secretion [ proceedings ] . | NA | {
"id": "C0038467",
"name": "strontium",
"pos": [
0,
9
]
} | {
"id": "C0025555",
"name": "alkaline-earth metal",
"pos": [
42,
62
]
} |
the pharmacokinetic characteristics of ticarcillin , a semisynthetic penicillin more active than carbenicillin against pseudomonas , were studied . | NA | {
"id": "C0040193",
"name": "ticarcillin",
"pos": [
39,
50
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
69,
79
]
} |
the investigations were performed at the temperatures of 26 degrees and 33 degrees c , representing the extreme values of the temperature range found in leg ulcers ( arteriosclerotic ulcers , stasis ulcers ) and at the ph corresponding to that of the enzyme preparations in wet dressings . | NA | {
"id": "C0023223",
"name": "leg",
"pos": [
153,
156
]
} | {
"id": "C0042344",
"name": "stasis ulcers",
"pos": [
192,
205
]
} |
the influence of four barbiturates , phenobarbital , barbital , thiopental , and pentobarbital , on bile secretion and on the hepatic microsomal system was studied in anesthetized rats . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
22,
34
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
86,
94
]
} |
the influence of four barbiturates , phenobarbital , barbital , thiopental , and pentobarbital , on bile secretion and on the hepatic microsomal system was studied in anesthetized rats . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
22,
34
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
81,
94
]
} |
to verify if pericarditis may be regarded as a marker of extensive mi , 60 patients with anterior or inferior mi admitted to the coronary care unit within 6 hours from onset of symptoms , were studied by clinical , electrocardiographic and enzymatic parameters . | NA | {
"id": "C0027051",
"name": "mi",
"pos": [
67,
69
]
} | {
"id": "C0340305",
"name": "inferior mi",
"pos": [
101,
112
]
} |
in subsequent tests of binding specificity , binding of the dimeric iga conjugate was inhibited by pretreating the tissues with unconjugated dimeric iga or 19s igm , pretreating the tissues with unconjugated antibodies to sc , or preincubating the dimeric iga conjugate with free sc . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
222,
224
]
} | {
"id": "C0020838",
"name": "iga",
"pos": [
256,
259
]
} |
it is suggested that the lamina propria macrophages may play a role in the phagocytosis of some migrating cells of the intestinal mucosa , most probably of the sheath-fibroblasts and/or intraepithelial lymphocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
167,
178
]
} |
the serum concentrations of cholic acid ( c ) , chenodeoxycholic acid ( cd ) , and deoxycholic acid ( d ) were determined in peripheral venous and portal venous blood from 10 otherwise healthy patients undergoing elective cholecystectomy . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
48,
69
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
83,
99
]
} |
nafcillin , a semisynthetic penicillin effective against penicillinase-producing staphylococci , is eliminated largely in man via the liver . | NA | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
0,
9
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
57,
67
]
} |
b ) pnd mutations do not restore the ability of purine auxotrophs ( pur ) defective in purine nucleoside phosphorylase ( pup ) and adenine phosphoribosyltransferase ( apt ) to grow on the medium with adenine as the sole source of purines . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
131,
138
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
230,
237
]
} |
in rats , maternal weight gain during the later third of pregnancy was correlated with fetal body weight , brain weight and dna content as well as placental weight near term . | NA | {
"id": "C0751992",
"name": "fetal body weight",
"pos": [
87,
104
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
157,
163
]
} |
in the soft tissues most common are ganglion , traumatic neuroma , nodular tenosynovitis , giant cell tumor of synovium , hygroma , foreign body granuloma and other inflammatory or metabolic alterations , as for example on the basis of degenerative arthritis or primary chronic polyarthritis . | NA | {
"id": "C0588125",
"name": "nodular tenosynovitis",
"pos": [
67,
88
]
} | {
"id": "C0017525",
"name": "giant cell",
"pos": [
91,
101
]
} |
effects of se-1520 were compared with those of thiazide diuretics , hydrochlorothiazide ( hct ) and trichlormethiazide ( tcm ) in rats and dogs . | NA | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
68,
87
]
} | {
"id": "C0040899",
"name": "trichlormethiazide",
"pos": [
100,
118
]
} |
trifluperidol , haloperidol and id-4708 ( a new butyrophenone derivative ) and chlorpromazine when given at low doses reduced ambulation , while at higher doses defecation was inhibited . | NA | {
"id": "C0040988",
"name": "trifluperidol",
"pos": [
0,
13
]
} | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
48,
61
]
} |
a series of 0.3 m sugars and 0.07 m nacl , 0.07 m sucrose , 0.004 m acetic acid and 0.00005 m quinine hydrochloride were used as taste stimuli . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
18,
24
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
50,
57
]
} |
the pharmacokinetics of diazepam and its biologically active major metabolite desmethyldiazepam were investigated under clinically relevant situations . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
24,
32
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
78,
95
]
} |
in patients with dysfunction of the liver ( cirrhosis , hepatitis ) diazepam and desmethyldiazepam exhibit a prolonged t1/2 ( beta ) and a reduced clearance and the lowered plasma protein binding causes a larger volume of distribution . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
68,
76
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
81,
98
]
} |
animal and in vitro experiments demonstrate , besides species dependent differences , that the elimination of diazepam can be impaired by the accumulating desmethyldiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
110,
118
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
155,
172
]
} |
[ antibiotics and chemotherapeutic agents . 2. cephalexin , caphazolin , cephapirin , cephradin , cephalosporin , erythromycin , macrolid antibiotics , lincomycin , clindamycin ] . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
152,
162
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
165,
176
]
} |
antiepileptic medication should be given in cases of one seizure or more a year , when epileptic origin is certain . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
57,
64
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
87,
96
]
} |
haemophilus influenzae in otitis media and sinusitis : serotypes and susceptibilty to ampicillin and amoxycillin in vitro . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
86,
96
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
101,
112
]
} |
there was a marked difference in the frequency of the mitochondrial antibodies , but not of the antinuclear factor and other autoantibody-like serum factors . | NA | {
"id": "C0003243",
"name": "antinuclear factor",
"pos": [
96,
114
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
125,
137
]
} |
the kinetic behaviour of the two ureido-penicillins was essentially very similar to that of ampicillin and carbenicillin , 38 patients with bronchopneumonia , cholangitis or urinary tract infections , which in some instances were severe , were treated for an average of 10 days with an average daily dosage of 3x4.0 g azlocillin or 3x5.0 g mezlocillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
92,
102
]
} | {
"id": "C0004499",
"name": "azlocillin",
"pos": [
318,
328
]
} |
the kinetic behaviour of the two ureido-penicillins was essentially very similar to that of ampicillin and carbenicillin , 38 patients with bronchopneumonia , cholangitis or urinary tract infections , which in some instances were severe , were treated for an average of 10 days with an average daily dosage of 3x4.0 g azlocillin or 3x5.0 g mezlocillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
92,
102
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
340,
351
]
} |
the phantom consisted of human ribs embedded in paraffin , the lungs of a dog injected with silicone rubber , a tissue equivalent wax heart and beeswax nodules . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
130,
133
]
} | {
"id": "C0004924",
"name": "nodules",
"pos": [
152,
159
]
} |
a circular osteotomy , used as a controlled fracture , was found to be extremely reproducible , and could be introduced with a minimum of trauma . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
44,
52
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
138,
144
]
} |
the enzymeconsists of 189 amino acid residues per molecule , neutral and acidic amino acids being present in high concentrations . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
26,
36
]
} | {
"id": "C0815040",
"name": "acidic amino",
"pos": [
73,
85
]
} |
the deae-cellulose chromatographic procedure which uses glycine-kcn-nacl solutions as developers and a nacl gradient to elute the hemoglobin zones was found to be useful for the quantitation of hb f in samples containing hb a , provided the level of hb f exceeds 2 percent . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
194,
196
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
250,
254
]
} |
the effects of 2 , 3-diphosphoglyceric acid ( 2 , 3-dpg ) , adenosine triphosphate ( atp ) , inositol tetraphosphate ( itp ) , inositol pentaphosphate ( ipp ) , and inositol hexaphosphate ( ihp ) on oxygen affinity of whole stripped hemoglobin ( wsh ) , hemoglobin h ( hb-h ; hatching hemoglobin ) , hemoglobin a ( hb-a ) , and hemoglobin d ( hb-d ) isolated from erythrocytes ( rbc ) of the 25-day turkey embryo have been studied . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
233,
243
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
300,
312
]
} |
the effect of ipp upon lowering the oxygen affinity of either wsh , hb-h , hb-a , or hb-d is approximately 20 percent less than ihp . | NA | {
"id": "C0019046",
"name": "wsh",
"pos": [
62,
65
]
} | {
"id": "C0019016",
"name": "hb-a",
"pos": [
75,
79
]
} |
experiments on protoporphyrin exchange between the hemoglobins a , f and s reinforced the previously drawn conclusion that protoporphyrin is bound to hemoglobin at the heme-binding sites . | NA | {
"id": "C0019016",
"name": "hemoglobins a",
"pos": [
51,
64
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
150,
160
]
} |
a cytochemical study of the human adrenal medulla showed that it is made up of two types , the adrenaline ( a- ) and noradrenaline ( n- ) storing cells . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
117,
130
]
} |
the apparent km for fe2+ is 20 micrometer in the absence of copper and 9.5 micrometer in the presence of 20 micrometer cucl2 . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
60,
66
]
} | {
"id": "C0056593",
"name": "cucl2",
"pos": [
119,
124
]
} |
when the metal ion complexing reagents ethylenediaminetetraacetic acid , phosphate ion , hydroxyl ion , or the competitive cations zn2+ or ca2+ are added to the sodium dodecyl sulfate-solubilized sample of outer membrane , and then the sample is heated to 100 degrees c and recooled to room temperature , the protein is almost completely converted to the high-temperature form . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
15,
18
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
123,
130
]
} |
the inhibitory effect of camp on e. coli ca7902 ( rts1 ) is specific to this cyclic nucleotide , and other cyclic nucleotides such as cyclic guanosine 3',5'-monophosphate did not have the effect . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
84,
94
]
} | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
107,
125
]
} |
this eclipse complex exhibited specific physical properties distinct from those of both pure dna single strands and native dna . | NA | {
"id": "C0012935",
"name": "dna single strands",
"pos": [
93,
111
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
123,
126
]
} |
these included a lower affinity for diethylaminoethyl-cellulose and hydroxylapatite than that of single-strand dna , faster sedimentation than the dna chains that it contains , and a buoyant density in cs2so4 lower than that of native dna . | NA | {
"id": "C0012935",
"name": "single-strand dna",
"pos": [
97,
114
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
235,
238
]
} |
to assess the effect of alteration of membrane structure on the enzymic activities related to phospholipid synthesis in microsomal membrane , the effects of several organic solvents have been studied in an in vitro system , in which the cytoplasmic extract prepared from rat liver incorporated [ 14c ] choline or [ 14c ] cdp-choline into phosphatidycholine ( lecithin ) . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
302,
309
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
321,
332
]
} |
lecithin : cholesterol acyltransferase ( lcat ) was more highly activated by apolipoprotein a-i ( apoa-i ) with dimyristoyl phosphatidylcholine ( dmpc ) than with dilinoleoyl phosphatidylcholine ( dlpc ) when lipid dispersion of cholesterol and each phosphatidylcholine was used as a substrate . | NA | {
"id": "C0012456",
"name": "dimyristoyl phosphatidylcholine",
"pos": [
112,
143
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
250,
269
]
} |
an enzyme system of mycobacterium smegmatis catalyzing the elongation of medium-chain fatty acids with acetyl-coa was obtained free from de novo fatty acid synthetase by ammonium sulfate fractionation . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
86,
97
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
127,
131
]
} |
the molecular weight of the heavy chain of nitella myosin , estimated by sds-gel electrophoresis , was slightly higher than that of skeletal muscle myosin . | NA | {
"id": "C0027100",
"name": "heavy chain",
"pos": [
28,
39
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
148,
154
]
} |
although the specific activity was lowered by the coupling , the immobilized enzyme was found to be far more stable to heat and extremes of ph than the native enzyme . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
65,
83
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
159,
165
]
} |
the immobilized enzyme was active toward rna even above ph 9 ( at 37 degree c ) or above 60 degree c ( at ph 7.5 ) , where the native enzyme was inactive . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
4,
22
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
134,
140
]
} |
the immobilized enzyme retained much of its activity as assayed at 37 degree c after incubation in the range of ph 1 to 10 at 37 degree c , or after heating at 100 degree c ( at ph 7.5 ) under conditions where the native enzyme was inactivated to a considerable extent . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
4,
22
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
221,
227
]
} |
the active site glutamic acid-58 in the immobilized enzyme appeared to be nearly as reactive with iodoacetate as that in the native enzyme . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
40,
58
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
132,
138
]
} |
the activation of phosphorylase kinase by this active protein kinase was not inhibited by a protein inhibitor of cyclic amp-dependent protein kinase , nor by ethylene glycol bis ( beta-aminoethyl ether ) n ' , n'-tetraacetic acid , which prevented autophosphorylation of phosphorylase kinase . | NA | {
"id": "C0033640",
"name": "protein kinase",
"pos": [
54,
68
]
} | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
271,
291
]
} |
in the presence of magnesium ions and atp , phosphorylase b was converted to phosphorylase a , and in an apparent biphasic process the phosphorylase a formed was subsequently converted to phosphorylase b . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
44,
57
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
188,
203
]
} |
kinetic studies showed that the higher specificity of the enzyme for nadh than nadph and for riboflavin and fmn than fad was primarily due to variations in the michaelis constants for the different substrates . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
93,
103
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
108,
111
]
} |
phenylglyoxal-modified apotryptophanase retains the capacity to bind the coenzyme , pyridoxal-p , but the spectrum of this reconstituted species differs from that of native holotryptophanase . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
73,
81
]
} | {
"id": "C0034266",
"name": "pyridoxal-p",
"pos": [
84,
95
]
} |
microsomes from livers of vitamin k-deficient rats , were incubated in the presence of cycloheximide , avidin , nadh , menaquinone-2 , 1 mm acetazolamide ( to inhibit carbonic anhydrase ) , and either 14co2 or h14co3- . | NA | {
"id": "C0042878",
"name": "vitamin k",
"pos": [
26,
35
]
} | {
"id": "C0086605",
"name": "menaquinone",
"pos": [
119,
130
]
} |
in contrast to activation by gpp ( nh ) p , activation of the enzyme by gtp proceeds not only without a lag phase but is of considerably lower magnitude . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
29,
41
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
72,
75
]
} |
these differences between gpp ( nh ) p and gtp can be explained by the hypothesis that gtp is hydrolyzed at the nucleotide regulatory site ( s ) associated with adenylate cyclase and that gtpase activity is revealed uniquely when the enzyme system is in its state of highest adenylate cyclase activity . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
26,
38
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
188,
191
]
} |
fetal bovine pancreatic poly ( a ) -containing rna directs the synthesis of an insulin immunoreactive polypeptide that is larger than proinsulin , preproinsulin , in the wheat germ cell-free translation system . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
79,
86
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
150,
160
]
} |
we have characterized this peptide in detail both immunologically and chemically and have shown that it is 2500 daltons larger than bovine proinsulin ( 8700 daltons ) , possesses both insulin and bovine c-peptide-specific antigenic determinants , and contains all the tryptic peptides found in bovine proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
142,
149
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
301,
311
]
} |
we have characterized this peptide in detail both immunologically and chemically and have shown that it is 2500 daltons larger than bovine proinsulin ( 8700 daltons ) , possesses both insulin and bovine c-peptide-specific antigenic determinants , and contains all the tryptic peptides found in bovine proinsulin . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
203,
212
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
301,
311
]
} |
preproinsulin synthesized in the wheat germ cell-free system was precipitated with approximately 4-fold greater efficiency by bovine proinsulin antiserum than by insulin antiserum . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
3,
13
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
162,
169
]
} |
its amino acid composition and apparent molecular weight estimated by sephadex g-25 chromatography , indicate that fts is a nonapeptide of composition lysine , aspartic acid ( or asparagine ) , serine 2 , glutamic acid ( or glutamine ) 2 , glycine 2 , and alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
240,
247
]
} |
its amino acid composition and apparent molecular weight estimated by sephadex g-25 chromatography , indicate that fts is a nonapeptide of composition lysine , aspartic acid ( or asparagine ) , serine 2 , glutamic acid ( or glutamine ) 2 , glycine 2 , and alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
256,
263
]
} |
its amino acid composition and apparent molecular weight estimated by sephadex g-25 chromatography , indicate that fts is a nonapeptide of composition lysine , aspartic acid ( or asparagine ) , serine 2 , glutamic acid ( or glutamine ) 2 , glycine 2 , and alanine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
205,
218
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
224,
233
]
} |
a calorimetric titration method was used to study the adp binding to the chymotryptic subfragments of myosin , heavy meromyosin ( hmm ) and myosin subfragment 1 ( s-1 ) , and to myosin aggregated into filaments at low ionic strength . | NA | {
"id": "C0027117",
"name": "subfragments",
"pos": [
86,
98
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
178,
184
]
} |
the iron-ovotransferrin-edta complex was prepared in the absence of bicarbonate , and a number of anions , including phosphate , sulfate , and citrate , were found to perturb the visible absorbance ( lambdamax = 490 nm ) of this complex . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
98,
104
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
117,
126
]
} |
the iron-ovotransferrin-edta complex was prepared in the absence of bicarbonate , and a number of anions , including phosphate , sulfate , and citrate , were found to perturb the visible absorbance ( lambdamax = 490 nm ) of this complex . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
98,
104
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
129,
136
]
} |
other anions , such as chloride , nitrate , and perchlorate , had little or no effect on the spectrum . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
6,
12
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
23,
31
]
} |
other anions , such as chloride , nitrate , and perchlorate , had little or no effect on the spectrum . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
6,
12
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
34,
41
]
} |
the locations of the sequences which code for 5 s , 5.8 s , 18 s , and 25 s ribosomal rnas have been determined by hybridization of the purified rna species with restriction endonuclease generated fragments of the repeating unit . | NA | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
76,
90
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
145,
148
]
} |
the position of the 5.8 s ribosomal dna sequences within the repeat was also established by sequencing the dna which codes for 83 nucleotides at the 5 ' end of 5.8 s ribosomal rna . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
26,
39
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
107,
110
]
} |
thionein-i is a single chain polypeptide which consists of 61 amino acid residues and has the amino acid composition cys20 , asp3 , asn1 , thr5 , ser9 , gln1 , pro2 , gly5 , ala5 , val2 , met1 , lys7 , with n-acetylmethionine and alanine as nh2- and cooh-terminal amino acids , respectively . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
230,
237
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
264,
275
]
} |
the transfer rna species previously shown to have an anticodon sequence complementary to arginine codons is affected by the psu4+op mutation . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
4,
16
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
53,
62
]
} |
although a distribution of spacer dna lengths exists , a significant proportion of spacers that are nearest neighbors share common dna lengths . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
both polypeptides resemble skeletal muscle myosin in their atp-sensitive co-sedimentation with actin , while they resemble the heavy chain of myosin and the lighter polypeptide of erythrocyte spectrin in their electrophoretic mobilities . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
43,
49
]
} | {
"id": "C0027100",
"name": "heavy chain",
"pos": [
127,
138
]
} |
the system has been applied to the detection of the pentafluoropropionyl derivatives of serotonin , methoxytryptamine , methoxytryptophol and 5-hydroxytryptophol by selective ion monitoring techniques . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
88,
97
]
} | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
100,
117
]
} |
a sensitive and selective method for the determination of the quaternary ammonium compound oxyphenonium bromide ( antrenyl ) , a drug with strong anticholinergic properties , in human plasma and urine is described . | NA | {
"id": "C0578399",
"name": "quaternary",
"pos": [
62,
72
]
} | {
"id": "C0030082",
"name": "antrenyl",
"pos": [
114,
122
]
} |
a sensitive and selective method for the determination of the quaternary ammonium compound oxyphenonium bromide ( antrenyl ) , a drug with strong anticholinergic properties , in human plasma and urine is described . | NA | {
"id": "C0086757",
"name": "oxyphenonium bromide",
"pos": [
91,
111
]
} | {
"id": "C0030082",
"name": "antrenyl",
"pos": [
114,
122
]
} |
the method is based on ion-pair extraction of the cation with perchlorate , a re-extraction according to ion-pair principles with tetrapentylammonium as the counter ion , hydrolysis to cyclohexylphenylglycolic acid , derivatization of this acid to its pentafluorobenzyl ester and determination of the ester by gas chromatography and electron-capture detection . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
50,
56
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
356,
359
]
} |
paracetamol and its four main metabolites , the sulphate ( s ) , glucuronide ( g ) , cysteine ( c ) and mercapturic acid ( m ) conjugates , are readily separated in a synthetic mixture using slightly acidic aqueous alcoholic eluents ( e.g . water-methanol-formic acid , 85:15:0.15 , v/v/v ) on either octadecyl silica ( ods silica ) or octadecyl silica which has been further silanized to remove residual hydroxyl groups ( ods/tms silica ) . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
85,
93
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
104,
120
]
} |
a rapid method was developed for the determination of diazepam and nordiazepam ( n-desmethyldiazepam ) in human plasma using electron capture gas -- liquid chromatography ( glc -- ece ) . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
54,
62
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
83,
100
]
} |
the concentration of diazepam and nordiazepam is determined using 0.5 ml of plasma extracted with 1.0 ml of benzene containing 25 ng/ml of methylnitrazepam as the internal standard . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
21,
29
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
34,
45
]
} |
the method has a sensitivity limit of 5 ng diazepam and 10ng nordiazepam per milliliter of plasma . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
43,
51
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
61,
72
]
} |
the threshold of serum osmolality causing release of vasopressin ( antidiuretic hormone ) was shifted to an abnormally low level ( 262 mosmol/kg h2o ) in a 14-year-old girl with hypertension and signs of hypoplastic corpus callosum . | NA | {
"id": "C0003779",
"name": "vasopressin",
"pos": [
53,
64
]
} | {
"id": "C0042413",
"name": "antidiuretic",
"pos": [
67,
79
]
} |
the serum concentrations of progesterone ( p ) , 17-oh-progesterone ( 17-ohp ) , 11-deoxycorticosterone ( doc ) , corticosterone ( b ) , 11-deoxycortisol ( s ) , 18-oh-11-deoxycorticosterone ( 18-oh-doc ) , aldosterone ( aldo ) and cortisol ( f ) were measured in 18 normal men ( m ) , 14 normal women in the folicular phase ( ff ) and 14 normal women in the luteal phase ( fl ) of menstrual cycle from blood samples obtained between 0800 and 0900 h . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
28,
40
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
49,
67
]
} |
the levels of serum somatomedin peptides were determined with a somatomedin a radioreceptor assay utilizing human placental membranes . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
20,
31
]
} | {
"id": "C0021666",
"name": "a somatomedin",
"pos": [
62,
75
]
} |
neither low-molecular-weight dextran sulfate-cacl ( 2 ) nor heparin-mncl ( 2 ) removed the pre-beta lipoproteins completely , and occasionally traces of beta-lipoprotein also remained after treatment . | NA | {
"id": "C0023825",
"name": "pre-beta lipoproteins",
"pos": [
91,
112
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
158,
169
]
} |
under the influence of inhibited phagosome formation by cytochalasin b , the cells released an increased amount of superoxide and peroxide into the extracellular medium relative to oxygen consumption , and all detectable peroxide release could be inhibited by the addition of ferricytochrome c . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
115,
125
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
221,
229
]
} |
the otherwise predictable complications of ptx in this metabolic setting ( hypocalcemia of increasing severity , tetany , moribundity , and death ) were prevented by continuous intravenous administration of calcium ( as a solution of calcium chloride/calcium gluconate 1:1 ) through a catheter in the external jugular vein placed at the time of ptx . | NA | {
"id": "C0020598",
"name": "hypocalcemia",
"pos": [
75,
87
]
} | {
"id": "C0039621",
"name": "tetany",
"pos": [
113,
119
]
} |
the otherwise predictable complications of ptx in this metabolic setting ( hypocalcemia of increasing severity , tetany , moribundity , and death ) were prevented by continuous intravenous administration of calcium ( as a solution of calcium chloride/calcium gluconate 1:1 ) through a catheter in the external jugular vein placed at the time of ptx . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
207,
214
]
} | {
"id": "C0006686",
"name": "calcium",
"pos": [
251,
258
]
} |
tolbutamide and glyburide , two other sulfonylurea compounds , also enhanced vasopressin-stimulated water flow and inhibited vasopressin-stimulated prostaglandin e biosynthesis . | NA | {
"id": "C0040374",
"name": "tolbutamide",
"pos": [
0,
11
]
} | {
"id": "C0038766",
"name": "sulfonylurea compounds",
"pos": [
38,
60
]
} |
tolbutamide and glyburide , two other sulfonylurea compounds , also enhanced vasopressin-stimulated water flow and inhibited vasopressin-stimulated prostaglandin e biosynthesis . | NA | {
"id": "C0017628",
"name": "glyburide",
"pos": [
16,
25
]
} | {
"id": "C0038766",
"name": "sulfonylurea compounds",
"pos": [
38,
60
]
} |
pyrimidine nucleotides , detectable in normal erythrocytes only in trace quantities if at all , were found to comprise 7-80 % of the intracellular nucleotide pools in nine subjects with severe lead over-burden . | NA | {
"id": "C0034288",
"name": "pyrimidine nucleotides",
"pos": [
0,
22
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
147,
157
]
} |
the interaction of dietary fibers and cholesterol upon the plasma lipids and lipoproteins , sterol balance , and bowel function in human subjects . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
66,
72
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
77,
89
]
} |
a two-way analysis of variance utilizing both groups of subjects indicated a significant ( p < 0.001 ) effect of dietary cholesterol upon the plasma cholesterol concentration . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
113,
132
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
149,
160
]
} |
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