text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the type of lymphoma was reviewed in the light of the new functional classifications of non-hodgkin malignant lymphomas introduced by lennert and lukes . | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
12,
20
]
} | {
"id": "C0024305",
"name": "non-hodgkin malignant lymphomas",
"pos": [
88,
119
]
} |
in a study of the lipoprotein pattern in multiple myelomatosis electrophoresis on agarose gel showed abnormal lipoproteins , named paralipoproteins ( p-lp ) , in 24 out of 30 normolipidaemic patients . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
135,
147
]
} |
that is , there was a 10-fold increase in the sensitivity of va13 to isoproterenol and the duration of action of the catecholamine was greatly prolonged . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
69,
82
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
117,
130
]
} |
in the absence of added calcium , protein coagulation occurred . near the iso-electric zone whereas in the presence of .03 m calcium chloride , similar protein coagulation occurred in the whole ph range ( ph 2 to ph 12 ) . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
24,
31
]
} | {
"id": "C0006686",
"name": "calcium",
"pos": [
125,
132
]
} |
this globulin had a much higher affinity for 25-hydroxycholecalciferol while vitamin d3 appeared to be associated first with an alpha-lipoprotein and with time because associated with the alpha-globulin . | NA | {
"id": "C0020337",
"name": "hydroxycholecalciferol",
"pos": [
48,
70
]
} | {
"id": "C0008318",
"name": "vitamin d3",
"pos": [
77,
87
]
} |
by using a cation-exchange distribution technique , the net charge of the technetium species produced in the reduction of pertechnetate by stannous ion at ph less than or equal to 2 had been determined to be + 2 . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
11,
17
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
148,
151
]
} |
supraventricular tachycardia is usually of marked degree and comes in isolated episodes and is not to be confused with tachycardia that is found accompanying fetal distress , occurring in pathological pregnancies . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
0,
28
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
119,
130
]
} |
auto-antibody to an ig vh region allotype : induction of anti-a1 antibody in an a1-suppressed a1a2 heterozygous rabbit . | NA | {
"id": "C0021006",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
65,
73
]
} |
most of the lymphokines , including migration inhibition factor , chemotactic factor for neutrophils , mitogenic factor , and lymphotoxin were generated by the first two fractions of lymphocytes , which represented the largest , most rapidly sedimenting cells . | NA | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
12,
23
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
126,
137
]
} |
lipid a-associated protein ( lap ) isolated from preparations of bacterial lipopolysaccharides ( lps , endotoxins ) has been demonstrated to initiate the release of amines from rat peritoneal mast cells . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
0,
7
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
97,
100
]
} |
lipid a-associated protein ( lap ) isolated from preparations of bacterial lipopolysaccharides ( lps , endotoxins ) has been demonstrated to initiate the release of amines from rat peritoneal mast cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
97,
100
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
103,
113
]
} |
the possibility is discussed that similar cross-reactive antibodies may have been involved in some previous studies of inhibition of t cell function by immunoglobulin antisera . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
57,
67
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
167,
175
]
} |
similarly , intact heterologous influenza a virus vaccine ( a/victoria/3/75 [ h3n2 ] ) potentiated the antibody response of hamsters to a/nj/76 [ hswl ni ] subunit vaccines but large doses of intact virus were required . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
50,
57
]
} | {
"id": "C0887892",
"name": "subunit vaccines",
"pos": [
156,
172
]
} |
tests also were performed with cephalexin , cephaloglycin , and cephadrine , as well as with the parenteral cephamycin antibiotic cefoxitin . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
31,
41
]
} | {
"id": "C0007721",
"name": "cephaloglycin",
"pos": [
44,
57
]
} |
tests also were performed with cephalexin , cephaloglycin , and cephadrine , as well as with the parenteral cephamycin antibiotic cefoxitin . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
108,
118
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
130,
139
]
} |
reproducible differences were detected between the matrix proteins of the above parents and allowed origin of the matrix proteins of the recombinant viruses to be determined . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
58,
66
]
} | {
"id": "C0034861",
"name": "proteins",
"pos": [
121,
129
]
} |
maps of the np proteins of the same strains showed a greater number of differences . | NA | {
"id": "C0028612",
"name": "np",
"pos": [
12,
14
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
15,
23
]
} |
the circular dna molecules were either the size of linear dna molecules or were shorter and corresponded to the length of the l ( long ) component of linear virus dna . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
58,
71
]
} |
close correlation of results was found between this method and a neutralization test employing mice , the one exception indicating that the in vitro assay for sensitizing antibody is more sensitive than the mouse assay for neutralizing antibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
171,
179
]
} | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
223,
244
]
} |
the incidence of solitary brain stem abscess is less than 4 % of all posterior fossa abscesses , and probably less than 1 % of all intracranial abscesses . | NA | {
"id": "C0006105",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0000833",
"name": "abscesses",
"pos": [
144,
153
]
} |
a case is reported showing that stuttering may be a presenting symptom of progressive neurological disease , and another case demonstrates that a speech disorder which is indistinguishable from common stuttering may follow cerebral follow injury in adulthood . | NA | {
"id": "C0037822",
"name": "speech disorder",
"pos": [
146,
161
]
} | {
"id": "C0038506",
"name": "stuttering",
"pos": [
201,
211
]
} |
the bioavailability of three commercial products of phenytoin ( epanutin , sodium salt ; phenhydan , calcium salt ; zentropil , free acid ) was studied relative to a standard solution of sodium phenytoin . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
52,
61
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
187,
203
]
} |
bsa disappears from the urine and 80-90 per cent . of the urinary protein is rat serum albumin . | NA | {
"id": "C0036774",
"name": "bsa",
"pos": [
0,
3
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
81,
94
]
} |
the records of 11 children with this condition , 7 ill neonates and 4 older children with burns , are then reviewed , indicating the clinical course of the disease , how they were treated , the results , and pathological findings . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
18,
26
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
70,
84
]
} |
statistical analysis revealed that ( -- ) -noradrenaline and ( +/- ) -alpha-methylnoradrenaline were tension selective whereas ( +/- ) -alpha-ethylisoprenaline and n-methyldopamine were rate selective relative to ( -- ) -isoprenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
43,
56
]
} | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
70,
95
]
} |
adrenaline , noradrenaline , and dopamine all caused a dose-dependent decrease in the force of the soleus contractions , their potencies being in that order . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
for the 1:1 hydrocortisone-lipid solid solutions , the rank order of the dissolution rate was hydrocortisone-cholesteryl stearate , hydrocortisone , hydrocortisone-cholesterol , hydrocortisone-cholesteryl acetate , hydrocortisone-cholesteryl palmitate , hydrocortisone-cholesteryl n-butyrate , hydrocortisone-cholesteryl laurate , and hydrocortisone-cholesteryl n-decylate . | NA | {
"id": "C0063077",
"name": "hydrocortisone",
"pos": [
12,
26
]
} | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
335,
349
]
} |
the zpc values of slightly soluble hydroxides were compared with their solubility product in the form of its negative logarithm , pksp , and with th ph of their suspensions in pure water , phsp , which is a function of pksp . | NA | {
"id": "C0020315",
"name": "hydroxides",
"pos": [
35,
45
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
181,
186
]
} |
the stability of prostaglandin e1 and dinoprostone was investigated at the extremes of the ph range ( less than or equal to 3 and greater than or equal to 10 ) in the sequence prostaglandin e leads to prostaglandin a leads to prostaglandin b . | NA | {
"id": "C0012472",
"name": "dinoprostone",
"pos": [
38,
50
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
176,
191
]
} |
the stability of prostaglandin e1 and dinoprostone was investigated at the extremes of the ph range ( less than or equal to 3 and greater than or equal to 10 ) in the sequence prostaglandin e leads to prostaglandin a leads to prostaglandin b . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
17,
32
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
226,
239
]
} |
the stability of prostaglandin e1 and dinoprostone was investigated at the extremes of the ph range ( less than or equal to 3 and greater than or equal to 10 ) in the sequence prostaglandin e leads to prostaglandin a leads to prostaglandin b . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
17,
30
]
} | {
"id": "C0033557",
"name": "prostaglandin b",
"pos": [
226,
241
]
} |
the bioavailability of clofibric acid from formulations containing calcium clofibrate along and mixed with calcium carbonate ( 1:1 w/w ) was compared to that from a standard clofibrate formulation in a crossover study in 12 human subjects . | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
23,
37
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
174,
184
]
} |
peaks of mean concentrations of 80 +/- 13,67 +/- 16 , and 64 +/- 18 microgram/ml +/- sd occurred after administration of 853 mg of clofibric acid calcium salt alone , 809 mg of clofibric acid calcium salt mixed with calcium carbonate , and 885 mg of clofibrate , respectively ; | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
131,
145
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
250,
260
]
} |
at ph 1.3 and 37 degrees , the adsorption capacity of activated charcoal ( milligrams per gram of charcoal ) was : aspirin , 262 ; | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
54,
72
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
98,
106
]
} |
the magnitude of the stabilizing action on lysosomes was greater than that of aspirin or oxyphenbutazone , similar to that of phenylbutazone , but less than that of prednisolone . | NA | {
"id": "C0030078",
"name": "oxyphenbutazone",
"pos": [
89,
104
]
} | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
126,
140
]
} |
in rats anesthetized with pentobarbital , pentazocine potentiated the pressor response of two exogenous amines , epinephrine and levarterenol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
113,
124
]
} | {
"id": "C0028351",
"name": "levarterenol",
"pos": [
129,
141
]
} |
cyclic amp , cyclic gmp and dibutyryl cyclic gmp have no effect on uptake or secretion.6 . | NA | {
"id": "C0018338",
"name": "cyclic gmp",
"pos": [
13,
23
]
} | {
"id": "C0012055",
"name": "dibutyryl cyclic gmp",
"pos": [
28,
48
]
} |
the activation by na ions and the effect of the anti-l antibody on the sodium pump of low-potassium type ( lk ) erythrocytes , have been studied by measuring ouabain-sensitive atpase activity of red cell membranes of lk goats . | NA | {
"id": "C0001479",
"name": "sodium",
"pos": [
71,
77
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
176,
182
]
} |
the results are discussed in terms of possible mechanisms whereby the sodium pump of lk and hk red cells may adjust the properties of their cation sites upon translocation of monovalent cations . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
140,
146
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
175,
193
]
} |
exposure to the catecholamines dopa and dopamine caused a decrease in light sensitivity , while 0.01 mm norepinephine , or isoproterenol did not affect photoresponsiveness . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
16,
30
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
40,
44
]
} |
exposure to the catecholamines dopa and dopamine caused a decrease in light sensitivity , while 0.01 mm norepinephine , or isoproterenol did not affect photoresponsiveness . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
16,
30
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
123,
136
]
} |
classical catecholamine blocking agents , dichloroisoproterenol , propranolol , and dibenzyline , and an inhibitor of dopa synthesis , alpha-methyl-rho-tyrosine , caused an increase in sensitivity . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
10,
23
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
118,
122
]
} |
substituent constant values obtained for benzomorphans are used in calculating log ( 1/c ) values for six morphinans . | NA | {
"id": "C0005075",
"name": "benzomorphans",
"pos": [
41,
54
]
} | {
"id": "C0026548",
"name": "morphinans",
"pos": [
106,
116
]
} |
the vital role of d-alanine and l-lysine in the peptidoglycan crosslinking process in the bacterial cell wall prompted preparation of various small peptides incorporating these amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
20,
27
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
177,
188
]
} |
subsequent structural variation showed that inclusion of c-alanine or l-lysine was not necessary , since antibacterial activity was at least as good when the dipeptide unite was replaced by glycylglycine or by an omega-aminoalkanoic acid . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
158,
167
]
} | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
190,
203
]
} |
radioimmunoassays detected an antibody in r17 antisera that binds to intact r17 but could not be absorbed from r17 antisera with ama31 . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
30,
38
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
115,
123
]
} |
in addition to single-stranded circular dna , we observed covalently closed and nicked replicative-form ( rf ) dnas , dimer rf dnas , concatenated rf dnas , rf dnas with single-stranded tails ( theta , rolling circles ) , and , occasionally , rf dnas with theta structures . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
111,
115
]
} | {
"id": "C1257941",
"name": "concatenated",
"pos": [
134,
146
]
} |
various subareas of interest within the field have emerged , such as pediatric trauma , associated injuries and the subdivisions of blunt and penetrating trauma . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
79,
85
]
} | {
"id": "C0043254",
"name": "penetrating trauma",
"pos": [
142,
160
]
} |
the syndrome of hypercalcemia in patients with renal cell carcinoma without metastasis to bone , in association with elevated levels of immunoreactive prostaglandin e and normal parathyroid hormone levels , prompted the investigation of an etiologic relationship of increased prostaglandin in this syndrome . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
151,
166
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
276,
289
]
} |
in the antisera against liu 0:13 and 0:14 there existed a strong antibody common to both antigens as well as an antibody specific to each antigen . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
112,
120
]
} |
[ effect of gastrin on the proliferation of cultured gastric mucosal cells . comparison of synthetic human gastrin and tetragastrin ] . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
12,
19
]
} | {
"id": "C0039659",
"name": "tetragastrin",
"pos": [
119,
131
]
} |
adsorption of hydrogen sulfide , methanethiol , methyl sulfide , trimethylamine , and ammonia on thirteen kinds of adsorbents ( 5 kinds of silicate , 4 kinds of activated carbon , and 4 kinds of zeolite ) was measured by gravimetry , at 30 degrees c and 50 torr , using an adsorption apparatus with a spring balance in order to find the most suitable adsorbent for the removal of these gases by dry process . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
86,
93
]
} | {
"id": "C0017110",
"name": "gases",
"pos": [
386,
391
]
} |
[ studies on the adsorption removal of ammonia gas . 2 ) adsorption of ammonia gas on several kinds of zeolites ( author 's transl ) ] . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
39,
46
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
79,
82
]
} |
[ estimation of rate constants for absorption , metabolism and excretion of trichloroethylene from urinary excretion data ( author 's transl ) ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
48,
58
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
107,
116
]
} |
this fraction , although seemed to resemble macromolecular fdp ( fibrinogen degradation product ) derived from stabilized fibrin , has many features not shared with the latter : 1 ) this fraction is sensitive to sodium dodecylsulfate ( sds ) treatment . | NA | {
"id": "C0163275",
"name": "fibrinogen degradation product",
"pos": [
65,
95
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
122,
128
]
} |
the effects of catecholamines ( adrenaline , noradrenaline and isoproterenol ) on ionic conductance changes during the generation of action potentials of bullfrog sympathetic and spinal ganglion cells were studied with intracellular microelectrodes . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
15,
29
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
63,
76
]
} |
the effects of catecholamines ( adrenaline , noradrenaline and isoproterenol ) on ionic conductance changes during the generation of action potentials of bullfrog sympathetic and spinal ganglion cells were studied with intracellular microelectrodes . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
32,
42
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
45,
58
]
} |
the action of noradrenaline was similar to that of adrenaline , but isoproterenol did not show any effects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
14,
27
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
51,
61
]
} |
the comparison of the areas under the glucose-concentration-curves in blood after the oral monosaccharide ( glucose and fructose ) and disaccharide ( saccharose ) -load , can be used as a measure for activity of saccharase in the intestinal mucosa . | NA | {
"id": "C0005802",
"name": "glucose",
"pos": [
38,
45
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
108,
115
]
} |
the comparison of the areas under the glucose-concentration-curves in blood after the oral monosaccharide ( glucose and fructose ) and disaccharide ( saccharose ) -load , can be used as a measure for activity of saccharase in the intestinal mucosa . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
135,
147
]
} | {
"id": "C0038636",
"name": "saccharose",
"pos": [
150,
160
]
} |
in 7 hypertensive patients with renal artery stenosis and in 1 patient with hypertension and unilateral pyelonephritic nephrophthisi the influence of the angiotensin ii antagonist , saralasin on systemic hemodynamics was studied . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
154,
168
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
182,
191
]
} |
in the present study , dog skin surface lipid was separated by preparative thin layer chromatography into sterol esters ( 42 % ) , wax diesters ( 32 % ) , free sterols ( 9 % ) , polar lipids ( 7 % ) , and unidentified components ( 10 % ) . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
131,
134
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
184,
190
]
} |
addition of ay-9944 or triparanol to the zuclomiphene treatment of the developing animals reduced desmosterol accumulation but brought about a build-up of 7-dehydrocholesterol and 7-dehydrodesmosterol . | NA | {
"id": "C0011704",
"name": "desmosterol",
"pos": [
98,
109
]
} | {
"id": "C0011181",
"name": "dehydrocholesterol",
"pos": [
157,
175
]
} |
we have postulated the existence of lipid-lipid and protein-lipid hydrogen bonding in the hydrogen belts of membranes , i.e. , the regions of hydrogen bond acceptors ( carbonyl oxygens of esters and amides ) and hydrogen bond donors ( hydroxyls of cholesterol , sphingosine , proteins , water ) . | NA | {
"id": "C0025252",
"name": "protein",
"pos": [
52,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
276,
284
]
} |
because disturbances of cardiac rhythm are ofter intermittent and evanescent , the development of systems for recording electrocardiograms in ambulatory patients for later analysis has been of clinical utility in diverse forms of heart disease . | NA | {
"id": "C0003811",
"name": "disturbances",
"pos": [
8,
20
]
} | {
"id": "C0018799",
"name": "of heart disease",
"pos": [
227,
243
]
} |
the penicillins were benzylpenicillin , ampicillin , carbenicillin , cloxacillin , and the recently described penicillin derivatives cyclacillin , ticarcillin , and pc-904 . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
21,
37
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
40,
50
]
} |
the penicillins were benzylpenicillin , ampicillin , carbenicillin , cloxacillin , and the recently described penicillin derivatives cyclacillin , ticarcillin , and pc-904 . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
21,
37
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
53,
66
]
} |
the penicillins were benzylpenicillin , ampicillin , carbenicillin , cloxacillin , and the recently described penicillin derivatives cyclacillin , ticarcillin , and pc-904 . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
4,
14
]
} | {
"id": "C0010523",
"name": "cyclacillin",
"pos": [
133,
144
]
} |
in clinical human serum albumin incompatibility , stimulation with albumin aggregates led to a high response in the lymphocyte culture , whereas deaggregated albumin had no stimulatory effect . | NA | {
"id": "C0304925",
"name": "human serum",
"pos": [
12,
23
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
158,
165
]
} |
[ endocrinopathy due to intracranial aneurysm ( part i ) -- direct kinetic effect of aneurysm on the hypothalamo pituitary system ( author 's transl ) ] . | NA | {
"id": "C0014130",
"name": "endocrinopathy",
"pos": [
2,
16
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
113,
122
]
} |
it is suggested that the absence of a correlation between the two parameters examined may depend on various factors , of which the most important are those pertaining to the rheological properties of red blood cells and to the structure and chemical and physical characteristics of the triglyceride molecule and of the lipoproteins and chylomicrons which transport them . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
319,
331
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
336,
348
]
} |
the concept of invalidity is viewed in terms of direct and associated anatomical damage and frank and potential invalidity ( absolute or relative ) , the weight or assistance attributable to the family and the incidence of the local social environment in the question of finding work , etc . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
154,
160
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
271,
278
]
} |
overall concentration of lipids and lipoproteins in plasma is determined by the interaction between several genetic and dietary feedback mechanisms . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
25,
31
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
36,
48
]
} |
human liver alcohol dehydrogenase , the principle ethanol oxidizing enzyme in man , exists in multiple molecular forms ( isoenzymes ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
68,
74
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
121,
131
]
} |
possible relationships of the individual isoenzyme pattern of alcohol dehydrogenase and of other alcohol metabolizing enzymes to the nature and extent of metabolic effects of ethanol are discussed . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
41,
50
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
118,
125
]
} |
differentiation of tumor from infection , however , frequently may be impossible , and the majority of bone lesions require biopsy for histologic confirmation of the type of tumor or for identification of the infectious organism . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
19,
24
]
} | {
"id": "C0027652",
"name": "histologic",
"pos": [
135,
145
]
} |
the following steroids were measured : pregnenolone , progesterone , deoxycorticosterone , corticosterone , aldosterone , 17-alpha-oh-pregnenolone , deoxycortisol , cortisol , cortisone , 17-alpha-oh-progesterone , dehydroepiandrosterone , androstendione , and testosterone . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
39,
51
]
} | {
"id": "C0376260",
"name": "17",
"pos": [
188,
190
]
} |
the following steroids were measured : pregnenolone , progesterone , deoxycorticosterone , corticosterone , aldosterone , 17-alpha-oh-pregnenolone , deoxycortisol , cortisol , cortisone , 17-alpha-oh-progesterone , dehydroepiandrosterone , androstendione , and testosterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
54,
66
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
188,
190
]
} |
approximately a quarter of maximum security hospital patients convicted of highly deviant crimes exhibited low 'anxiety-type ' psychophysiological responsivity to stressors together with an abnormal catecholamine balance during stressor anticipation which resulted in noradrenalin to adrenalin ratios in excess of 5.5 , an abnormally high value not exceeded by any control subjects and a result which is significant ( p less than 0.005 ) . | NA | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
268,
280
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
284,
293
]
} |
the efficacy of therapy is judged by the cessation of bleeding or thrombosis , improvement of organic dysfunction , and correction of the levels of the coagulation factors , particularly factor v and fibrinogen . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
152,
171
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
187,
195
]
} |
causes , risks and treatment of cardiac arrhythmias are discussed with special reference to extrasystoles developing during anaesthesia . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
40,
51
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
92,
105
]
} |
a simple procedure for the preparation of agarose suitable for electrophoresis is developed in which anionic polysaccharides are removed by extracting the agar gel-granules with phosphate buffer ( 0.03 m , ph 6.8 ) containing urea ( 4 m ) , followed by electrophoresis in the same buffer system . | NA | {
"id": "C0036681",
"name": "agarose",
"pos": [
42,
49
]
} | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
109,
124
]
} |
newborn rats injected on days 1-8 of life with l-phenylalanine ( 2 g/kg ) and p-chlorophenylalanine ( 80 mg/kg ) displayed biochemical symptoms analogous to human phenylketonuria ( pku ) and maze learning impairments . | NA | {
"id": "C0031453",
"name": "l-phenylalanine",
"pos": [
47,
62
]
} | {
"id": "C0030135",
"name": "p-chlorophenylalanine",
"pos": [
78,
99
]
} |
cardiac amyloidosis showed no significant correlations with other factors studied which included ecg evidence of left ventricular hypertrophy , ischaemia and bundle branch block , pathological evidence of cardiac enlargement or ischaemia , diagnosis of malignant disease , generalized wasting and the occurrence of digitalis toxicity . | NA | {
"id": "C0149721",
"name": "left ventricular hypertrophy",
"pos": [
113,
141
]
} | {
"id": "C0018800",
"name": "cardiac enlargement",
"pos": [
205,
224
]
} |
[ absorption , distribution , excretion and metabolism of sc-11800ee , a combined steroid preparation of sc-11800 ( ethynodiol diacetate ) and ethinyl estradiol in rats and mice ( author 's transl ) ] . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
30,
39
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
44,
54
]
} |
absorption , distribution , excretion and metabolism of sc-11800ee , a combined steroid preparation consisting of sc-11800 ( ethynodiol diacetate ) as gestagen and ethinyl estradiol ( ee ) as estrogen in 20:1 ( w : w ) , were studied with the use of 14c-sc-11800 and 3h-ee by radiometry in female rats and by the whole body autoradiography in female normal and pregnant mice . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
28,
37
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
42,
52
]
} |
the antisera using at final dilution of 1 : 10,000 have been prepared by immunizing synthetic human proinsulin connecting peptide to rabbits for human proinsulin c-peptide radioimmunoassay . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
100,
110
]
} | {
"id": "C0006558",
"name": "human",
"pos": [
145,
150
]
} |
those results suggested that main antigen determinant in n terminal 31-38 of human proinsulin connecting peptide . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
83,
93
]
} | {
"id": "C0006558",
"name": "connecting peptide",
"pos": [
94,
112
]
} |
the long-term local intraperitoneal foreign-body reaction with some cylinders remaining unanchored , frequent failure to develop a fibrous capsule at the outside of the tin cylinder , and a degree of lympho-histiocytic involvement and adenomatous hyperplasia in the fibrosis within the tin cylinder differed from the foreign-body reaction at the subcutaneous site characterized by avascular , cell-poor fibrosis with fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
393,
397
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
417,
428
]
} |
the delayed results ( 1 -- 20 years ) were good in 62 % of the patients with iiird-degree eye lesions and in 17 % of the patients in the organofunctional stage ii , in 17 % of the patients in stage ii -- iii of restricted necrosis , and in 4 % of the patients in gangrenous stage iii . | NA | {
"id": "C0027540",
"name": "necrosis",
"pos": [
222,
230
]
} | {
"id": "C0017086",
"name": "gangrenous",
"pos": [
263,
273
]
} |
in a series of experiments several idiotype-specific rabbit antisera produced against different igg anti-rh ( d ) antibodies reacted with other anti-rh ( d ) antibodies and thus showed cross-idiotypic reactions . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
60,
68
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
158,
168
]
} |
[ clostridium infections with and without manifest gas gangrene . report on 77 infections in 76 patients ] . | NA | {
"id": "C0009062",
"name": "clostridium infections",
"pos": [
2,
24
]
} | {
"id": "C0017105",
"name": "gas gangrene",
"pos": [
51,
63
]
} |
systematic microbiological research and correlation of the histopathological findings obtained from random autopsies revealed 23 hitherto undetected clostridial infections including 11 cases of gas gangrene , 4 of septicemia , 3 of bacteremia , and 5 other clostridial infections . | NA | {
"id": "C0017105",
"name": "gas gangrene",
"pos": [
194,
206
]
} | {
"id": "C0009062",
"name": "clostridial infections",
"pos": [
257,
279
]
} |
on the basis of clinical and histopathological criteria they have been classified as follows : 22 cases with gas gangrene ( clostridial myonecrosis ) , 16 cases with anaerobic cellulitis , 20 wound infections , 8 cases of septicemia , 5 of bacteriemia , 1 of tetanus , and 5 other clostridial infections . | NA | {
"id": "C0017105",
"name": "clostridial myonecrosis",
"pos": [
124,
147
]
} | {
"id": "C0009062",
"name": "clostridial infections",
"pos": [
281,
303
]
} |
on the basis of clinical and histopathological criteria they have been classified as follows : 22 cases with gas gangrene ( clostridial myonecrosis ) , 16 cases with anaerobic cellulitis , 20 wound infections , 8 cases of septicemia , 5 of bacteriemia , 1 of tetanus , and 5 other clostridial infections . | NA | {
"id": "C0039614",
"name": "tetanus",
"pos": [
259,
266
]
} | {
"id": "C0009062",
"name": "clostridial infections",
"pos": [
281,
303
]
} |
the leukemoid reaction with leukocytosis of up to 102 300 white cells per microliter , 65 % of which were eosinophils , was observed during the last two months of life of the patient , who died of multiple metastasis of malignant melanoma . | NA | {
"id": "C0023501",
"name": "leukemoid reaction",
"pos": [
4,
22
]
} | {
"id": "C0023518",
"name": "leukocytosis",
"pos": [
28,
40
]
} |
contraindications for total fasting appear to be clinical sings of arteriosclerosis such as vascular bruits , angina pectoris and intermittent claudication . | NA | {
"id": "C0003850",
"name": "arteriosclerosis",
"pos": [
67,
83
]
} | {
"id": "C0021775",
"name": "intermittent claudication",
"pos": [
130,
155
]
} |
no other arrhythmias , augmentation in the number of premature beats or atrio-ventricular blockade were observed . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
9,
20
]
} | {
"id": "C0340464",
"name": "premature",
"pos": [
53,
62
]
} |
fowl plague virus ( fpv ) , vesicular stomatitis virus ( vsv ) , bt 20 mammary carcinoma cells and chicken embryo fibroblasts ( cef ) were used as assay systems . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
89,
94
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} |
in order to study in more detail the possibility of transporting aerosols produced by combustion over long distances , the distribution of heavy hydrocarbons ( polycyclic and paraffinic ) on atmospheric particles has been studied according to their diameter . | NA | {
"id": "C0020242",
"name": "hydrocarbons",
"pos": [
145,
157
]
} | {
"id": "C0030415",
"name": "paraffinic",
"pos": [
175,
185
]
} |
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