text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
surgical specimens were obtained in 29 patients , with subsequent diagnoses of 22 chromophobe adenomas , five eosinophilie adenomas , one cystic adenoma , and one necrotic tumor . | NA | {
"id": "C0001432",
"name": "chromophobe adenomas",
"pos": [
82,
102
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
145,
152
]
} |
the tetracyclines , including minocycline , should not be used to treat bacterial pneumonia since resistant strains of pneumococci are not uncommon and inffective treatment can lead to rapid progression of the infection . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
4,
17
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
30,
41
]
} |
exercise-induced asthma can effectively be prevented by pre-exercise treatment with sympathomimetic drugs or sodium cromoglycate , and there is no reason why an asthmatic should not participate in sporting activities . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
0,
23
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
161,
170
]
} |
the dose of infused fragment d was chosen to achieve observed plasma concentrations of fibrin split products in hospitalized patients with severe burns or trauma ( about 100mug of fsp/ml of blood ) . | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
146,
151
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
155,
161
]
} |
tissue residues and concentrations of benzylpenicillin , cloxacillin , ampicillin , amoxycillin , cephapirin , and cephacetrile were determined in normal dairy cows after parenteral administration of several forms of these drugs . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
38,
54
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
71,
81
]
} |
tissue residues and concentrations of benzylpenicillin , cloxacillin , ampicillin , amoxycillin , cephapirin , and cephacetrile were determined in normal dairy cows after parenteral administration of several forms of these drugs . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
71,
81
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
84,
95
]
} |
tissue residues and concentrations of benzylpenicillin , cloxacillin , ampicillin , amoxycillin , cephapirin , and cephacetrile were determined in normal dairy cows after parenteral administration of several forms of these drugs . | NA | {
"id": "C0007737",
"name": "cephapirin",
"pos": [
98,
108
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
115,
127
]
} |
treatment consisted in intravenous injection of 3,000 i.u . of human chorionic gonadotrophin plus 125 mg. of progesterone ( nymfalon '' '' or intramuscular injection of 0.2 mg. of gonadotrophin-releasing hormone ( lutal '' '' . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotrophin",
"pos": [
63,
92
]
} | {
"id": "C0018061",
"name": "gonadotrophi",
"pos": [
79,
91
]
} |
the antisera , as analzyed by complement fixation , cross-reacted with synthetic double stranded rnas ( poly ( a ) -poly ( u ) , poly ( i ) -poly ( c ) ) , but not with native or denatured dna , rrna , trna , 5 s rna and nucleic acids from rice plants . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
195,
199
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
213,
216
]
} |
as regards immunoglobulin classes of the antibodies , one of the two rabbits employed had antibody activity only in igg . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
11,
33
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
41,
51
]
} |
pulmonary arterial pressure-flow relation was studied in 142 patients with artrial septal defect ( asd ) and was compared with that of 139 patients with ventricular septal defect ( vsd ) and was compared with that of ductus arteriosus ( pda ) . | NA | {
"id": "C0018816",
"name": "septal defect",
"pos": [
83,
96
]
} | {
"id": "C0018818",
"name": "ventricular septal defect",
"pos": [
153,
178
]
} |
fluoride impairment of glucose utilization : nature of effect in rats during and after continuous naf infusion . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
0,
8
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
98,
101
]
} |
the much better compatibility of zn-dtpa as compared to ca-dtpa was fully confirmed also with respect to the hematological and coagulation parameters . | NA | {
"id": "C0013254",
"name": "dtpa",
"pos": [
36,
40
]
} | {
"id": "C0520458",
"name": "ca-dtpa",
"pos": [
56,
63
]
} |
estrone ( e1 ) , progesterone ( p ) , 17-hydroxyprogesterone ( 17ohp ) , testosterone ( t ) , dihydrotestosterone ( dht ) , and androstenedione ( a ) , dehydroepiandrosterone ( dha ) and dehydroepiandrosterone sulfate ( dhas ) levels were not altered in either maturity group . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
17,
29
]
} | {
"id": "C0020387",
"name": "17ohp",
"pos": [
63,
68
]
} |
antibodies to mestranol crossreacted more than 100 percent with ethynylestradiol and to a small extent with norethindrone and norgestrel . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
14,
23
]
} | {
"id": "C0015011",
"name": "ethynylestradiol",
"pos": [
64,
80
]
} |
for cytochromoxidase and na+ , k+-atpase it lowers considerably in all subfractions , for monoaminoxidase and mg2+-atpase it rises mainly in synaptosomes ; | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
34,
40
]
} | {
"id": "C0001477",
"name": "mg2",
"pos": [
110,
113
]
} |
[ dynamics and kinetics of 14c-nicotinic acid uptake by leukocytes and erythrocytes as an index of vitamin pp transport regulation ] . | NA | {
"id": "C0027996",
"name": "nicotinic acid",
"pos": [
31,
45
]
} | {
"id": "C0028027",
"name": "vitamin pp",
"pos": [
99,
109
]
} |
synthetic drugs include quaternary ammonium compounds with antimuscarinic activity such as methantheline , propantheline , and other drugs such as isopropamide , pipenzolate methylbromide , and diphemanil methylsulfate . | NA | {
"id": "C0578399",
"name": "quaternary ammonium compounds",
"pos": [
24,
53
]
} | {
"id": "C0033447",
"name": "propantheline",
"pos": [
107,
120
]
} |
based on a series of 100 cases , the paper reviews the causes , diagnosis and treatment of apparent bowel obstruction in cattle with particular emphasis on non-obstructive tympanitic disorders of the intestine . | NA | {
"id": "C0021843",
"name": "of",
"pos": [
18,
20
]
} | {
"id": "C0021831",
"name": "disorders of",
"pos": [
183,
195
]
} |
in aujeszky 's disease antisera neutralizing and complement fixing antibodies have been deomonstrated in titres up to 1:64 , and in mk antisera -- cf-antibodies only . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
23,
31
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
150,
160
]
} |
treatment with neuraminidase ( 100 units/ml ) of chick embryo fibroblasts in vitro only partially inhibits adsorption of fowl plague virus on these cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
148,
153
]
} |
cultivation of chick embryo fibroblasts in the presence of 50 units/ml neuraminidase had no effect on the sensitivity of these cells to fowl plague virus and on the extent of virus reproductions . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
28,
39
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} |
the fusion of fpv-infected and 3h-uridine labeled ehrlich ascitic carcinoma cells with infected unlabeled chicken fibroblasts using inactivated sendai virus resulted in production of two types of labeled virus particles : with a buoyant density in cesium chloride gradient of 1.29 g/cm3 characteristic of particles produced by infected ehrlich cells and buoyant density 1.22 g/cm3 typical of standard influenza virus . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
344,
349
]
} |
infected chicken fibroblasts in hybrids were shown not to use the radioactive pool of ehrlich cells and , accordingly , the virus with the density of 1.22 g/cm3 if formed from components pre-existing in ehrlich cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
17,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} |
the authors studied the renal function in 80 patients with balkan endemic nephropathy ( ben ) , 27 males and 53 females , aged from 29-67 , by radioisotope clearance ( edta -- 16 9yb and hippuran -- 131j ) and isotope nephrogram ( ing ) . | NA | {
"id": "C0034595",
"name": "radioisotope",
"pos": [
143,
155
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
210,
217
]
} |
hemoptysis is one of the most important symptoms of cardiopulmonary disease-first , because bleeding even in small amounts may indicate the presence of such serious diseases as bronchogenic carcinoma or active tuberculosis , and second , because untreated massive hemorrhage is associated with a high mortality rate . | NA | {
"id": "C0019079",
"name": "hemoptysis",
"pos": [
0,
10
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
92,
100
]
} |
absence of hla-b 27 does not exclude ankylosing spondylitis , as 7.4 % of the classical cases are hla-b27-negative . | NA | {
"id": "C0019737",
"name": "hla-b",
"pos": [
11,
16
]
} | {
"id": "C0019740",
"name": "hla-b27",
"pos": [
98,
105
]
} |
it is not the simple relation of heart to body weight of 1/200 that is used , but -- depending on the body weight -- 1/175 for normal weight , 1/150 for underweight and 1/200 for overweight . | NA | {
"id": "C0005910",
"name": "body",
"pos": [
42,
46
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
179,
189
]
} |
the degree of arteriosclerosis in 176 autopsies of liver cirrhosis ( patients in the age range of 51 to 70 years ) was compared with that of controls ( without liver disease ) . | NA | {
"id": "C0023890",
"name": "of liver cirrhosis",
"pos": [
48,
66
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
160,
173
]
} |
the results of a multicenter trial covering 6 trauma departments are presented with an analysis of 199 distal fractures and follow-up in 164 cases . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
46,
52
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
110,
119
]
} |
in the irreversible lymphoedema ( stage iii ) and in the elephantiasis ( stage iv ) the following operations have been developed : ligature of ectatic lymphtrunks , peripheral lymphovenous and lymphadenovenous shunts , skin-flap transplantations , free or pediculated transplantation of the greater omentum , lymphangioplastic operations ( thompson-operation ) or excisional operations ( servelle-operation ) . | NA | {
"id": "C0024236",
"name": "lymphoedema",
"pos": [
20,
31
]
} | {
"id": "C0013882",
"name": "elephantiasis",
"pos": [
57,
70
]
} |
[ induction of labor with prostaglandin f 2 alpha ( a comparative study using oxytocin and prostaglandin ) ] . | NA | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
26,
41
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
91,
104
]
} |
in this evolution of special importance were bimetallic enzymes , such as nitrogenase , some nitrate reductases and hydrogenases , carbon dioxide reductase , xanthine oxidase , cytochrome oxidase . | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
74,
85
]
} | {
"id": "C0030016",
"name": "reductase",
"pos": [
146,
155
]
} |
in this evolution of special importance were bimetallic enzymes , such as nitrogenase , some nitrate reductases and hydrogenases , carbon dioxide reductase , xanthine oxidase , cytochrome oxidase . | NA | {
"id": "C0020284",
"name": "hydrogenases",
"pos": [
116,
128
]
} | {
"id": "C0030016",
"name": "reductase",
"pos": [
146,
155
]
} |
a modified method of chromatographic analysis was used to obtain fractions of immunoglobulins classes m , g , and a from the sera of patients suffering from salmonelloses , typhoid fever , and carriers ; | NA | {
"id": "C0036117",
"name": "salmonelloses",
"pos": [
157,
170
]
} | {
"id": "C0041466",
"name": "typhoid fever",
"pos": [
173,
186
]
} |
in case of an uncomplicated affection there was an increase of antibodies of all the three immunoglobulin classes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
63,
73
]
} | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
91,
113
]
} |
subcutaneous sensitization of guinea pigs with -vaccine , and also an intracardiac injection of smallpox or measles vaccine induced production of brain autoantibodies , whereas subcutaneous or intradermal immunization of the animals with liver viral vaccines was not accompanied by the formation of autoantibodies and development of the pathological processes in the nervous system tissue . tthe greatest changes in the brain tissue in the form of circulatory disturbances and inflammatory-dystrophic phenomena in combination with high autoantibody titres in the blood were noted in intracardiac injection of smallpox vaccine and in subturbancessensitization with ak-vaccine and the least ( short-term circulatory disturbances , transitory signs of serous meningitis and neuron dystrophy against the background of low blood auto anitbody content ) -- in intracardiac injection of measles vaccine . | NA | {
"id": "C0042742",
"name": "viral vaccines",
"pos": [
244,
258
]
} | {
"id": "C0025010",
"name": "measles vaccine",
"pos": [
880,
895
]
} |
sera of healthy and sick persons were tested for the presence of secretory iga ( siga ) and free secretory component ( sc ) siga was present in the blood of healthy persons in low concentrations ( 1.07 mg/100 mg ) , and free sc was absent . | NA | {
"id": "C0020838",
"name": "secretory",
"pos": [
65,
74
]
} | {
"id": "C0036538",
"name": "sc",
"pos": [
225,
227
]
} |
treatment of immune complexes consisting of different antigens and corresponding igg with low doses of hydrochloric cystein led to the antibody inactivation , to the complex splitting , and to the release of the antigen . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
13,
29
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
135,
143
]
} |
the paper deals with the possible mechanism in the development of a hemorrhagic brain infarction during myocardial infarction , complicated by a cardiogenic shock of the iii degree . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
104,
125
]
} | {
"id": "C0036980",
"name": "cardiogenic",
"pos": [
145,
156
]
} |
the 24 h excretion and renal clearance of 6 high molecular weight proteins : albumin , transferrin , haptoglobin , igg , iga , and igm were significantly increased compared with a control group , implying a glomerular injury . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
66,
74
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
77,
84
]
} |
interest was focused upon the islets of guinea-pigs , due to the fact that guinea-pig insulin lacks a histidine residue in the b10 position of the molecule which normally binds zinc ( or other heavy metals ) in the hexamer formation , probably involved in the storage of insulin . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
177,
181
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
193,
205
]
} |
instead , it was suggested that guinea-pig insulin , like hagfish insulin , might crystallize without access to zinc or other heavy metals . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
112,
116
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
126,
138
]
} |
the peripheral plasma levels of 20alpha-dihydroprogesterone ( 20alpha-dhp ) , progesterone ( p ) and 17-hydroxyprogesterone ( 17-ohp ) were measured by radioimmunoassay techniques in 440 samples during normal human pregnancy between weeks 4 and 41 . | NA | {
"id": "C0012311",
"name": "dihydroprogesterone",
"pos": [
40,
59
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
111,
123
]
} |
the peripheral plasma levels of 20alpha-dihydroprogesterone ( 20alpha-dhp ) , progesterone ( p ) and 17-hydroxyprogesterone ( 17-ohp ) were measured by radioimmunoassay techniques in 440 samples during normal human pregnancy between weeks 4 and 41 . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
47,
59
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
101,
123
]
} |
the range of mean plasma concentration of p during the first trimester of pregnancy fell to a nadir in the 9th week ( 170 ng/ml ) then rose with increased gestation until the 39th week ( 190.4 ng/ml ) followed by a slight and not significant drop . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
55,
70
]
} | {
"id": "C0032961",
"name": "gestation",
"pos": [
155,
164
]
} |
both tsh and catecholamines increased the concentration of organified iodine in thyroid cell despite the presence of active transport inhibitors , suggesting either the existence of a second thyroidal transport system or the possibility of an accelerated entry of anions into thyroid cells in the presence of stimulatory agents . | NA | {
"id": "C0021966",
"name": "iodine",
"pos": [
70,
76
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
264,
270
]
} |
five patients with chronic post-operative hypoparathyroidism were treated with 450 microgram/day 5,6-trans-25-hydroxyvitamin d3 ( 5,6-trans-25ohd3 ) for 14 days , and the treatment was continued with 150 microgram/day for one year . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
107,
127
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
140,
146
]
} |
at the end of this period the patients received 450 microgram/day 5,6-cis-25-hydroxyvitamin d3 ( 5,6-cis-25ohd3 ) for 14 days . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin",
"pos": [
74,
91
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
105,
111
]
} |
islets of treated rats released significantly more insulin and incorporated significantly less [ 3h ] leucine into proinsulin and insulin compared with controls when tested at 100 mg glucose/100 ml . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
115,
125
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
130,
137
]
} |
simultaneous determination of the content of serotonin , dopamine , noradrenaline and adrenaline in pancreatic islets isolated from fed and starved mice . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
86,
96
]
} |
a highly sensitive double isotope method for the simultaneous determination of serotonin , dopamine , noradrenaline and adrenaline has been developed . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
102,
115
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
120,
130
]
} |
the hypothesis that the impaired glucose-induced insulin secretion during starvation partly is caused by an increased content of biogenic amines in the pancreatic islets was not supported by our experiments which showed an unchanged islet content of these amines after 48 h starvation . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
129,
144
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
256,
262
]
} |
the results showed that the gill secretes the mucosubstances consisting of neutral mucins , sulfomucins , sialomucins and atypical high ph azurophilic mucosubstances having alcianophilia at ph = 5.6 . | NA | {
"id": "C0026682",
"name": "mucins",
"pos": [
83,
89
]
} | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
106,
117
]
} |
in a double-blind trial , in a total of 45 patients , sulfentanil was compared with fentanyl and morphine in equipotent doses , as a narcotic supplement to anesthesia . | NA | {
"id": "C0143993",
"name": "sulfentanil",
"pos": [
54,
65
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
84,
92
]
} |
initially , morphine was shown to have a significantly longer duration of effect than fentanyl and sulfentanil , which for the first 3 doses had similar durations of action to each other . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
86,
94
]
} | {
"id": "C0143993",
"name": "sulfentanil",
"pos": [
99,
110
]
} |
the provocation tests were performed with the following allergens : house dust , mites , human dander and pollen , and with histamine . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
56,
65
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
68,
78
]
} |
our findings suggest that at least 7 mg of iron as ferrous sulphate per litre of formula is required to prevent iron deficiency . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
43,
47
]
} | {
"id": "C0060282",
"name": "ferrous sulphate",
"pos": [
51,
67
]
} |
juvenile diabetes mellitus , optic atrophy , hearing loss , diabetes insipidus , atonia of the urinary tract and bladder , and other abnormalities ( wolfram syndrome ) . | NA | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
60,
78
]
} | {
"id": "C0043207",
"name": "wolfram",
"pos": [
149,
156
]
} |
it can only be stated that neurohypophyseal diabetes insipidus can be a component of the syndrome and that in many cases -- particularly in the presence of lesions of the efferent urinary tract -- the possibility of nephrogenous diabetes insipidus can not be excluded with certainty . | NA | {
"id": "C0687720",
"name": "neurohypophyseal diabetes",
"pos": [
27,
52
]
} | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
229,
247
]
} |
it seems probable that the same mechanism can be held responsible for the lesions of the olfactory , optic , vestibular and cochlear nerves , the hypophyseal form of diabetes insipidus , retarded sexual maturation , abnormal pupillary reaction , myelopathy and the electro-encephalographic , electroneurological and electromyographic changes in the wolfram syndrome . | NA | {
"id": "C0011848",
"name": "diabetes insipidus",
"pos": [
166,
184
]
} | {
"id": "C0043207",
"name": "wolfram syndrome",
"pos": [
349,
365
]
} |
two mixtures of either allogeneic para-adenovirus 12 tumor cells or adenovirus ( adeno ) 12 tumor cells and sv40 tumor cells in an equal number of 1 multiplied by 10 ( 7 ) cells were transplanted subcutaneously at two sites of 10 young hamsters . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
23,
33
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
the ultrastructure of blood mononuclear cells from two igg myeloma patients was studied , and cells reacting with anti-idiotypic serum and polyspecific anti-ig serum were characterized by immunoperoxidase techniques . | NA | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
22,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
94,
99
]
} |
it is concluded that chondroitinase abc digest chondroitin-4 and -6 sulphate and to some extent also hyaluronic acid and dermatan sulphate , but not heparin and keratosulphate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
21,
32
]
} | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
121,
138
]
} |
the release from the depot , hydrolysis and distribution in the organsim as well as the metabolism and elimination of intramuscularly injected clopenthixol decanoate in viscoleo have been studied in dogs and rats with radioactive as well as non-labelled drug after single as well as repeated administration . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
88,
98
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
103,
114
]
} |
a rapid exchange in the organism between tritium from the drugs and hydrogen from the body water was demonstrated . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
41,
48
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
68,
76
]
} |
the cation exchanger properties of the mast cell granules were investigated by testing the applicability of the rothmund-kornfeld equation for cation exchangers to the binding of na+ and hi+ ions to granule sites . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
4,
10
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
191,
195
]
} |
influence of low temperatures on vascular effects produced adrenaline , noradrenaline and vasoconstrictor nerve stimulation was studied in the feet of ducks . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
59,
69
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
72,
85
]
} |
during cooling of the foot the influence of vasoconstrictor nerve stimulation and low doses of adrenaline and noradrenaline on vascular resistance is gradually lost , and it is negligible at temperatures below 8 degrees c . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} |
blood glucose and plasma insulin levels were studied under fasting conditions and following an i.v . and an oral glucose load , respectively , in nine males with moderate hypertension before treatment , after one month on placebo and after three months on the cardioselective beta-receptor blocking agent metoprolol . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
0,
13
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
113,
120
]
} |
the reproducibility of blood glucose and plasma insulin values following an i.v . glucose load was very good . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
23,
36
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
82,
89
]
} |
medication with metoprolol caused no changes in the fasting levels of blood glucose or plasma insulin , nor in the blood glucose response following a glucose load given i.v . or orally . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
45,
47
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
150,
157
]
} |
following oral glucose both the total integrated blood glucose response and the insulin response were unaffected by treatment with metoprolol . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
15,
22
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
49,
62
]
} |
in the 60 's stereotactic electrocoagulation of the dentate nucleus became a promising approach in the neurosurgical treatment of muscular hypertonicity , particularly when spasticity was evident . | NA | {
"id": "C0026826",
"name": "muscular hypertonicity",
"pos": [
130,
152
]
} | {
"id": "C0026838",
"name": "spasticity",
"pos": [
173,
183
]
} |
moderately hypercholesterolemic rabbits hydrolyzed chylomicron tg at the same rate as normal animals , but were found to accumulate partially degraded intestinal lipoproteins of sf 100-400 and sf 20-100 . | NA | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
51,
62
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
162,
174
]
} |
hydroxyl groups in serine side chains of collagen , silk fibroin , and bovine serum albumin ( bsa ) were converted to sh by tosylation . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
52,
56
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
57,
64
]
} |
experiments with glutaraldehyde and primary alkyl amines as model componds revealed that the cyclic form of the aldehyde gave the unstable n-alkyl-2,6-dihydroxypiperidine , which either looses water to give n-alkyldihydropyridine or condenses with 2,6-dihydroxytetrahydropyran to yield a copolyether which was isolated . | NA | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
17,
31
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
112,
120
]
} |
somewhat surprisingly , we found that the rates for formation of several native proteins in uncatalyzed systems containing gssg and gsh are as great as with the `` '' shuffle-ase '' '' enzyme , suggesting that a substantial portion of biological thiol oxidations proceed by uncatalyzed exchange . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
123,
127
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
132,
135
]
} |
peroxydisulfate anion in aqueous solutions is a strong oxidizing agent decomposing to sulfate free radicals and subsequently to hydroxyl radicals . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
16,
21
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
86,
93
]
} |
bisulfite catalyzes the binding of cytosine to polylysine , lysine to polycytidylic acid , and polysine to polycytidylic acid . | NA | {
"id": "C0032518",
"name": "polylysine",
"pos": [
47,
57
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
97,
103
]
} |
since cm-1.4 and m1a are present on 17s ig h chains , and absent from 7s ig , they probably represent allotypic markers in the constant region of 17s ig h chains . | NA | {
"id": "C0021027",
"name": "ig",
"pos": [
40,
42
]
} | {
"id": "C0021008",
"name": "constant region",
"pos": [
127,
142
]
} |
these antisera are able to distinguish lymphocytic from myeloid leukemia cells , and can also identify acute myelomonocytic leukemia and chronic myelocytic leukemia blastic crisis cells from cells of other types of leukemia . | NA | {
"id": "C0023470",
"name": "myeloid leukemia",
"pos": [
56,
72
]
} | {
"id": "C0023479",
"name": "acute",
"pos": [
103,
108
]
} |
these antisera are able to distinguish lymphocytic from myeloid leukemia cells , and can also identify acute myelomonocytic leukemia and chronic myelocytic leukemia blastic crisis cells from cells of other types of leukemia . | NA | {
"id": "C0023470",
"name": "myeloid leukemia",
"pos": [
56,
72
]
} | {
"id": "C0023473",
"name": "chronic myelocytic leukemia",
"pos": [
137,
164
]
} |
the methylated derivatives of phenobarbital , carba-mazepine , primidone , and diphenyl-hydantoin were separated on the chromatogram , and the peaks were sharp and symmetrical . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
30,
43
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
63,
72
]
} |
detectable hcg was not found in any subject , but in four subjects delayed lh pulses resulted in apparent low levels of hcg because of cross-reactivity in the hcg beta subunit radioimmunoassay . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
11,
14
]
} | {
"id": "C0106132",
"name": "hcg beta subunit",
"pos": [
159,
175
]
} |
the latter system is inhibited to various degrees by phloretin , theophylline , cytochalasin b , and a variety of flavonones and flavones , including apigenin . | NA | {
"id": "C0016219",
"name": "flavones",
"pos": [
129,
137
]
} | {
"id": "C0912024",
"name": "apigenin",
"pos": [
150,
158
]
} |
the incorporation of a subcutaneous injection of [ 14c ] riboflavin ( 2.5 muci/100 g body wt ) into flavin mononucleotide ( fmn ) , flavin adenine dinucleotide ( fad ) , and flavins bound covalently to proteins was determined at 1 , 6 , and 18 h in liver , cerebrum , and cerebellum from progeny of normal and maternally riboflavin-deficient holtzman rats . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
124,
127
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
321,
331
]
} |
the incorporation of a subcutaneous injection of [ 14c ] riboflavin ( 2.5 muci/100 g body wt ) into flavin mononucleotide ( fmn ) , flavin adenine dinucleotide ( fad ) , and flavins bound covalently to proteins was determined at 1 , 6 , and 18 h in liver , cerebrum , and cerebellum from progeny of normal and maternally riboflavin-deficient holtzman rats . | NA | {
"id": "C0016213",
"name": "flavins",
"pos": [
174,
181
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
321,
331
]
} |
in both groups of newborn rats , the incorporation of radioactive riboflavin into covalently bound flavins in liver and brain proceeded more slowly than into the other flavin fractions . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
66,
76
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
99,
106
]
} |
these data provide evidence that maternal riboflavin deficiency enhances the incorporation of riboflavin into tissue flavins in liver , cerebrum , and cerebellum from newborn rats . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
42,
52
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
117,
124
]
} |
it has previously been reported that in the dog the michaelis constant ( km ) of renal renin with respect to homologous plasma substrate is the same as that for the angiotensin-generating enzyme extractable from the myometrium during pregnancy . | NA | {
"id": "C0003017",
"name": "renin",
"pos": [
87,
92
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
165,
176
]
} |
with the exception of benign solitary blunt wounds of the pancreas to the body of the gland immediately ventral to the spinal column , an injury of the pancreas is evidence that the abdomen has been subjected to severe trauma , which predisposes the patient to a high mortality and morbidity . | NA | {
"id": "C0043253",
"name": "blunt wounds",
"pos": [
38,
50
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
219,
225
]
} |
there was one episode of immediate postoperative hemorrhage and one of delayed bleeding , but there were no anesthetic complications . | NA | {
"id": "C0032788",
"name": "postoperative hemorrhage",
"pos": [
35,
59
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
79,
87
]
} |
quantitative determination of the glutathione , cysteine , and n-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
48,
56
]
} | {
"id": "C0001047",
"name": "n-acetyl cysteine",
"pos": [
63,
80
]
} |
calcium binding properties of monovalent anions commonly used to substitute for chloride in physiological salt solutions . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
41,
47
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
80,
88
]
} |
a research study and discussion of antiinterferon immunoglobulin in the treatment of rheumatoid arthritis and systemic lupus erythematosus , and its possible value in the treatment of allergic diseases , autoimmune diseases and other diseases where it is presumed there may be an autoimmune genesis . | NA | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
110,
138
]
} | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
204,
223
]
} |
comparison of a new aminoglycoside ( g-418 ) and gentamicin for the treatment of swine dysentery in swine naturally infected with salmonella choleraesuis . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
20,
34
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
49,
59
]
} |
hence a plasma apolipoprotein-e concentration exceeding 40 mg/dl appears diagnostic of type iii hyperlipoproteinemia , representing the first application of an apolipoprotein immunoassay to improved diagnosis of the hyperlipoproteinemias . | NA | {
"id": "C0003595",
"name": "apolipoprotein-e",
"pos": [
15,
31
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
160,
174
]
} |
pristinamycin and virginiamycin , two antibiotics belonging to the streptogramin group , are widely used in france against staphylococcal infections . | NA | {
"id": "C0205996",
"name": "pristinamycin",
"pos": [
0,
13
]
} | {
"id": "C0205997",
"name": "streptogramin",
"pos": [
67,
80
]
} |
pristinamycin and virginiamycin , two antibiotics belonging to the streptogramin group , are widely used in france against staphylococcal infections . | NA | {
"id": "C0042754",
"name": "virginiamycin",
"pos": [
18,
31
]
} | {
"id": "C0205997",
"name": "streptogramin",
"pos": [
67,
80
]
} |
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